CN106466347A - A kind of storage heat clearing away bath effervescent tablets and preparation method thereof - Google Patents
A kind of storage heat clearing away bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466347A CN106466347A CN201510513280.0A CN201510513280A CN106466347A CN 106466347 A CN106466347 A CN 106466347A CN 201510513280 A CN201510513280 A CN 201510513280A CN 106466347 A CN106466347 A CN 106466347A
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Abstract
A kind of storage heat clearing away bath effervescent tablets and preparation method thereof, are made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, store 50-70 part, Lignum corni macrophyllae 15-20 part, Flos Nelumbinis 15-20 part, Pericarpium Pyri 8-12 part, Amaranthus mangostanus L. 8-12 part, Calculus Macacae Mulattae 5-8 part, Semen vignae sinensiss 5-8 part, Semen Cassiae Sopherae 5-8 part, Corm Brassicae caulorapae 5-8 part, Gracilaria tenuistipitata 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.The a kind of of the present invention stores heat clearing away bath effervescent tablets, and life-time service has functions that heat clearing away, diuresis, parasite killing.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of storage heat clearing away bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of heat clearing away or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Store heat clearing away bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of store heat clearing away bath effervescent tablets and preparation method thereof, life-time service has the effect of heat clearing away, diuresis, parasite killing.
The purpose of the present invention is achieved through the following technical solutions：
A kind of storage heat clearing away bath effervescent tablets and preparation method thereof, are made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stores 50-70 part, Lignum corni macrophyllae 15-20 part, Flos Nelumbinis 15-20 part, Pericarpium Pyri 8-12 part, Amaranthus mangostanus L. 8-12 part, Calculus Macacae Mulattae 5-8 part, Semen vignae sinensiss 5-8 part, Semen Cassiae Sopherae 5-8 part, Corm Brassicae caulorapae 5-8 part, Gracilaria tenuistipitata 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of storage, 18 parts of Lignum corni macrophyllae, 17 parts of Flos Nelumbinis, 12 parts of Pericarpium Pyri, 10 parts of Amaranthus mangostanus L., 8 parts of Calculus Macacae Mulattae, 7 parts of Semen vignae sinensiss, 6 parts of Semen Cassiae Sopherae, 5 parts of Corm Brassicae caulorapae, 5 parts of Gracilaria tenuistipitata.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of store heat clearing away bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the storage of selection high-quality, Lignum corni macrophyllae, Flos Nelumbinis, Pericarpium Pyri, Amaranthus mangostanus L., Calculus Macacae Mulattae, Semen vignae sinensiss, Semen Cassiae Sopherae, Corm Brassicae caulorapae, Gracilaria tenuistipitata, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of storing heat clearing away bath effervescent tablets.
In medicine：Store diuresis, heat clearing away, parasite killing, control pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid swell, eczema；Lignum corni macrophyllae promoting blood circulation and stopping pain；Nourishing blood and preventing abortion；Main injury and bone fracture；Swelling and pain due to blood stasis；Blood deficiency and yellow complexion；Frequent fetal movement；Flos Nelumbinis promoting blood circulation and hemostasis, dry pathogenic wind expelling；Control and fall damage hematemesis, sky steeps eczema；Pericarpium Pyri clearing away heart-fire and moistening the lung, pathogenic fire reducing promotes the production of body fluid；Control summer-heat excessive thirst, cough, spit blood, carbuncle on the back, furuncle；Amaranthus mangostanus L. heat clearing away, dampness removing, removing toxic substances, detumescence；Control dysentery, have blood in stool, edema, leucorrhea, cholelithiasis, scrofula, hemorrhoid, furuncle, laryngalgia, venom；Calculus Macacae Mulattae removing phlegm to relieve convulsion, heat-clearing and toxic substances removing, control expectorant dyspnea of heat type and cough, pediatric epilepsy scared, scrofula subcutaneous nodule；Semen vignae sinensiss strengthening spleen, tonifying kidney；Control weakness of the spleen and stomach, dysentery, tell inverse, quench one's thirst, seminal emission, leucorrhea, nebulousurine, frequent micturition；Semen Cassiae Sopherae liver heat removing and eyesight improving, during stomach invigorating is adjusted, intestine moistening is detoxified；Main conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, oral erosion, habitual constipation, infantile malnutrition, dysentery, malaria；Corm Brassicae caulorapae controls stranguria with turbid discharge, hematochezia of defecating, toxic swelling, sinusitis with purulent discharge；Gracilaria tenuistipitata heat clearing away；Resolving phlegm and softening hard masses；Diuretic；Main interior-heat；Expectorant ties goiter；Dysuria
.
Beneficial effects of the present invention：One kind of the present invention
Store heat clearing away bath effervescent tablets, to pyretic stranguria, difficulty in urination etc.
Main
Disease
Card serves to varying degrees
Heat clearing away, diuresis, parasite killing
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Oral Liquid Radix Panacis Quinquefolii
, once a day, it is within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 27 years old, clinical manifestation is pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of storage heat clearing away bath effervescent tablets and preparation method thereof, are made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stores 50-70 part, Lignum corni macrophyllae 15-20 part, Flos Nelumbinis 15-20 part, Pericarpium Pyri 8-12 part, Amaranthus mangostanus L. 8-12 part, Calculus Macacae Mulattae 5-8 part, Semen vignae sinensiss 5-8 part, Semen Cassiae Sopherae 5-8 part, Corm Brassicae caulorapae 5-8 part, Gracilaria tenuistipitata 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of storage, 18 parts of Lignum corni macrophyllae, 17 parts of Flos Nelumbinis, 12 parts of Pericarpium Pyri, 10 parts of Amaranthus mangostanus L., 8 parts of Calculus Macacae Mulattae, 7 parts of Semen vignae sinensiss, 6 parts of Semen Cassiae Sopherae, 5 parts of Corm Brassicae caulorapae, 5 parts of Gracilaria tenuistipitata.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of store heat clearing away bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the storage of selection high-quality, Lignum corni macrophyllae, Flos Nelumbinis, Pericarpium Pyri, Amaranthus mangostanus L., Calculus Macacae Mulattae, Semen vignae sinensiss, Semen Cassiae Sopherae, Corm Brassicae caulorapae, Gracilaria tenuistipitata, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of storing heat clearing away bath effervescent tablets.
Claims (8)
1. a kind of store heat clearing away bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stores 50-70 part, Lignum corni macrophyllae 15-20 part, Flos Nelumbinis 15-20 part, Pericarpium Pyri 8-12 part, Amaranthus mangostanus L. 8-12 part, Calculus Macacae Mulattae 5-8 part, Semen vignae sinensiss 5-8 part, Semen Cassiae Sopherae 5-8 part, Corm Brassicae caulorapae 5-8 part, Gracilaria tenuistipitata 5-8 part.
2. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of storage, 18 parts of Lignum corni macrophyllae, 17 parts of Flos Nelumbinis, 12 parts of Pericarpium Pyri, 10 parts of Amaranthus mangostanus L., 8 parts of Calculus Macacae Mulattae, 7 parts of Semen vignae sinensiss, 6 parts of Semen Cassiae Sopherae, 5 parts of Corm Brassicae caulorapae, 5 parts of Gracilaria tenuistipitata.
3. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. according to claim 1 a kind of store heat clearing away bath effervescent tablets it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of according to claim 1-7 store heat clearing away bath effervescent tablets and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the storage of selection high-quality, Lignum corni macrophyllae, Flos Nelumbinis, Pericarpium Pyri, Amaranthus mangostanus L., Calculus Macacae Mulattae, Semen vignae sinensiss, Semen Cassiae Sopherae, Corm Brassicae caulorapae, Gracilaria tenuistipitata, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of storing heat clearing away bath effervescent tablets.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510513280.0A CN106466347A (en) | 2015-08-20 | 2015-08-20 | A kind of storage heat clearing away bath effervescent tablets and preparation method thereof |
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|---|---|---|---|
| CN201510513280.0A CN106466347A (en) | 2015-08-20 | 2015-08-20 | A kind of storage heat clearing away bath effervescent tablets and preparation method thereof |
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| CN106466347A true CN106466347A (en) | 2017-03-01 |
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