CN106459035B - N2‑苯基‑吡啶并[3,4‑d]嘧啶‑2,8‑二胺衍生物及其作为mps1抑制剂的用途 - Google Patents

N2‑苯基‑吡啶并[3,4‑d]嘧啶‑2,8‑二胺衍生物及其作为mps1抑制剂的用途 Download PDF

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Publication number
CN106459035B
CN106459035B CN201580010416.4A CN201580010416A CN106459035B CN 106459035 B CN106459035 B CN 106459035B CN 201580010416 A CN201580010416 A CN 201580010416A CN 106459035 B CN106459035 B CN 106459035B
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China
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methyl
bases
pyrimidine
phenyl
amine
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Expired - Fee Related
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CN201580010416.4A
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Chinese (zh)
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CN106459035A (zh
Inventor
汉纳·伍德沃
保罗·伊诺森蒂
塞巴斯蒂安·诺德
J·布拉格
斯文·赫尔德
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201580010416.4A 2014-02-28 2015-02-27 N2‑苯基‑吡啶并[3,4‑d]嘧啶‑2,8‑二胺衍生物及其作为mps1抑制剂的用途 Expired - Fee Related CN106459035B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1403536.4A GB201403536D0 (en) 2014-02-28 2014-02-28 Inhibitor compounds
GB1403536.4 2014-02-28
PCT/GB2015/050590 WO2015128676A1 (en) 2014-02-28 2015-02-27 N2-phenyl-pyrido[3,4-d]pyrimidine-2,8-diamine derivatives and their use as mps1 inhibitors

Publications (2)

Publication Number Publication Date
CN106459035A CN106459035A (zh) 2017-02-22
CN106459035B true CN106459035B (zh) 2018-04-06

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CN201580010416.4A Expired - Fee Related CN106459035B (zh) 2014-02-28 2015-02-27 N2‑苯基‑吡啶并[3,4‑d]嘧啶‑2,8‑二胺衍生物及其作为mps1抑制剂的用途

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US (2) US9902721B2 (enExample)
EP (2) EP3575299B1 (enExample)
JP (1) JP6440728B2 (enExample)
CN (1) CN106459035B (enExample)
AU (1) AU2015221956B2 (enExample)
BR (1) BR112016019733B1 (enExample)
CA (1) CA2939058C (enExample)
ES (2) ES2739148T3 (enExample)
GB (1) GB201403536D0 (enExample)
RU (1) RU2693460C2 (enExample)
WO (1) WO2015128676A1 (enExample)

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JP2020524169A (ja) * 2017-06-20 2020-08-13 ジ・インスティチュート・オブ・キャンサー・リサーチ：ロイヤル・キャンサー・ホスピタル 方法および医学的利用
GB201809458D0 (en) 2018-06-08 2018-07-25 Crt Pioneer Fund Lp Salt form
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CA3130478A1 (en) * 2019-03-13 2020-09-17 Voronoi Co., Ltd. Heteroaryl derivatives, and pharmaceutical composition comprising the same as active ingredient
CN115385840B (zh) * 2022-09-05 2024-07-02 北京京宇复瑞科技集团有限责任公司 制备3-甲氧基氮杂环丁烷盐酸盐的方法

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WO2012101032A1 (en) * 2011-01-26 2012-08-02 Nerviano Medical Sciences S.R.L. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
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Also Published As

Publication number Publication date
AU2015221956A1 (en) 2016-07-07
EP3110816A1 (en) 2017-01-04
JP2017506661A (ja) 2017-03-09
US9902721B2 (en) 2018-02-27
WO2015128676A1 (en) 2015-09-03
ES2739148T3 (es) 2020-01-29
BR112016019733A2 (enExample) 2017-08-15
RU2693460C2 (ru) 2019-07-03
AU2015221956B2 (en) 2019-05-09
EP3110816B1 (en) 2019-06-19
GB201403536D0 (en) 2014-04-16
JP6440728B2 (ja) 2018-12-19
RU2016137789A (ru) 2018-04-03
RU2016137789A3 (enExample) 2018-10-23
EP3575299A1 (en) 2019-12-04
CN106459035A (zh) 2017-02-22
US20160362409A1 (en) 2016-12-15
CA2939058A1 (en) 2015-09-03
EP3575299B1 (en) 2022-07-20
CA2939058C (en) 2022-04-26
ES2926641T3 (es) 2022-10-27
BR112016019733B1 (pt) 2022-12-20
US20180194761A1 (en) 2018-07-12
US10399974B2 (en) 2019-09-03

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Granted publication date: 20180406