CN106421575A - Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition - Google Patents
Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition Download PDFInfo
- Publication number
- CN106421575A CN106421575A CN201611232605.9A CN201611232605A CN106421575A CN 106421575 A CN106421575 A CN 106421575A CN 201611232605 A CN201611232605 A CN 201611232605A CN 106421575 A CN106421575 A CN 106421575A
- Authority
- CN
- China
- Prior art keywords
- filtrate
- solution
- composition
- bulbus lilii
- aloe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004877 mucosa Anatomy 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 201000008100 Vaginitis Diseases 0.000 title abstract description 3
- 230000003260 anti-sepsis Effects 0.000 title abstract 2
- 108010022355 Fibroins Proteins 0.000 claims abstract description 15
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 10
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960002233 benzalkonium bromide Drugs 0.000 claims abstract description 10
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 9
- 239000000706 filtrate Substances 0.000 claims description 30
- 241001116389 Aloe Species 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 235000011399 aloe vera Nutrition 0.000 claims description 24
- 238000000605 extraction Methods 0.000 claims description 17
- 206010061218 Inflammation Diseases 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 10
- 229910052709 silver Inorganic materials 0.000 claims description 9
- 239000004332 silver Substances 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000003651 drinking water Substances 0.000 claims description 3
- 235000020188 drinking water Nutrition 0.000 claims description 3
- 229940088598 enzyme Drugs 0.000 claims description 3
- 238000001976 enzyme digestion Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 claims description 2
- 240000008384 Capsicum annuum var. annuum Species 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 208000024891 symptom Diseases 0.000 abstract description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 3
- 239000004471 Glycine Substances 0.000 abstract description 2
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 230000036541 health Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 229940069521 aloe extract Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 10
- 230000001408 fungistatic effect Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 208000008350 Pruritus Vulvae Diseases 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 3
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000001387 Causalgia Diseases 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- 208000014439 complex regional pain syndrome type 2 Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000005186 women's health Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Insects & Arthropods (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a composition for antisepsis and anti-inflammation of vagina mucosas and a preparation method of the composition. The composition mainly comprises fibroin, nano silver, benzalkonium bromide, soybean glycine, cortex dictamni, radix stemonae, pericarpium zanthoxyli, belvedere fruits, borneol, aloe extract and lily extract. The composition has the advantages that the composition is made from the traditional Chinese medicinal materials, treats both symptoms and root causes, and has small irritation and toxic and side effects; the fibroin has good moisturizing performance and is rich in many kinds of amino acids, and accordingly, the composition has a certain health care effect.
Description
Technical field
The invention belongs to pharmaceutical field, specially a kind of compositionss for vaginal mucosa anti-inflammation and its preparation side
Method.
Background technology
The high speed development of society greatly improves the living standard of people, and women's health is also increasingly taken seriously, so
And gynaecopathia seriously threatens the healthy of China women, it is in rejuvenation trend development in recent years.In gynaecopathia Middle Palace
The disease incidences such as neck inflammation, pelvic inflammatory disease, vaginitiss, cervical erosion, pruritus vulvae are high, these common gynecological diseases and the multiple course of disease
Degree differently have impact on the physical and mental health of numerous women.Study carefully its pathogenic factor invariably directly or indirectly with such as antibacterial, funguses or
Not viral quasi-microorganism infection is relevant.Treating and preventing above-mentioned disease ground medicine is antibiotics mostly, such as clotrimazole, fluorine health
Azoles, Bifonazole etc..The dosage form using has vaginal suppository, effervescent tablet, external wash liquid etc., due to the pathogeny of these diseases, especially
It is the complexity of pathogenic microorganism, the particularity of site of pathological change environment, and above-mentioned antibiotics antimicrobial spectrum limitation and
Drug resistance, some medicines initially to certain fungus effectively, just create Resistant strain after a period of time and invalid, and some medicines
Poor to antibacterial particularly anaerobe effect, absolutely void to virus.
Content of the invention
The present invention is intended to provide a kind of good effect, the non-irritating compositionss for vaginal mucosa anti-inflammation and its system
Preparation Method.
The technical scheme is that：
A kind of compositionss for vaginal mucosa anti-inflammation, count by weight ratio, and said composition is made up of following raw material：
Silk fibroin powder 3-5 part, nanometer silver solution 2-3 part of 1000ppm, benzalkonium bromide 0.5-1 part, Cortex Dictamni 3-5 part, the Radix Stemonae
1-2 part, Fructus Zanthoxyli 0.5-1 part, Fructus Kochiae 2-3 part, Borneolum Syntheticum 0.5-1 part, Aloe extraction solution 0.1-0.2 part, Bulbus Lilii extracting solution 0.5-1
Part.
Further, described compositionss, count by weight ratio and are made up of following raw material：
4 parts of silk fibroin powder, 2.5 parts of the nanometer silver solution of 1000ppm, 0.5 part of benzalkonium bromide, 4 parts of Cortex Dictamni, 1 part of the Radix Stemonae, river
0.5 part of green pepper, 2 parts of the Fructus Kochiae, 1 part of Borneolum Syntheticum, 0.1 part of Aloe extraction solution, 0.5 part of Bulbus Lilii extracting solution.
Further, described Aloe extraction solution is obtained by following preparation method：
Take Aloe, chopping, soak 0.5-1 hour with drinking water, be subsequently adding the cellulase of Aloe weight 0.5-1.0%, use salt
Acid for adjusting pH value digests 15-45min to 4.0-6.0, ultrasonic wave added；After enzyme digestion reaction, feed liquid is warming up to 90-110 DEG C, enzyme denaturing
1-5 minute, filters, and filtrate is standby；The filtering residue of gained is extracted twice with ethanol solution：It is heated to micro-boiling, reflux, extract, 1-2 is little
When；Filter；Merge filtrate twice, concentrating filtrate to relative density after reclaiming ethanol is 1.1-1.2, obtain Aloe and extract
Liquid.
Further, described Bulbus Lilii extracting solution is obtained by following preparation method：
Take Bulbus Lilii, with the ethanol solution of the 75-90% of 10 times of weight impregnate 60-90min, under conditions of 40-45 DEG C with
The power ultrasonic of 3000-4000W filters after extracting 30-40min；The ethanol solution with the 60-75% of 10 times of weight is ultrasonic again for filtering residue
Extract, condition ibid, filters, filtrate is standby twice for merging, and it is 1.1-1.2 that filtrate is concentrated into relative density, obtains Bulbus Lilii extracting solution.
A kind of preparation method of the compositionss for vaginal mucosa anti-inflammation comprises the following steps：
（1）Measure after Cortex Dictamni, the Radix Stemonae, Fructus Zanthoxyli and the Fructus Kochiae be pulverized and mixed by formula, with 10 times of its four Chinese medicine gross weight
After water soaks 30 minutes, then decoct twice, 2 hours every time, filter, merging filtrate be concentrated into relative density obtain for 1.1-1.2 dense
Contracting filtrate is standby；
（2）By the silk fibroin powder of formula ratio, the nanometer silver solution of 1000ppm, benzalkonium bromide, Borneolum Syntheticum, Aloe extraction solution and
Bulbus Lilii extracting solution and step（1）Gained concentrates after filtrate is uniformly mixed and obtains compositionss.
The beneficial effects of the present invention is：
（1）, to vaginal mucosa anti-inflammation, effect is good for the present invention, not repeatedly, and stimulates little, toxic and side effects little；
（2）The present invention extracts Aloe extraction solution and Bulbus Lilii extracting solution using unique extraction process, and cooperation silk fibroin powder makes
Obtain its skin-friendly, moisture retention preferably, compatible with Cortex Dictamni, the Radix Stemonae, Fructus Zanthoxyli, the Fructus Kochiae, there is synergism, not only to vagina
Mucosa has beneficial antibacterial anti-inflammatory effects, also has good health-care effect to vaginal mucosa.
The special fibroin adding of the present invention, and fibroin is the natural polymer fibrin extracting from silkworm silk,
Content accounts for the 70%～80% of silkworm silk, and containing 18 kinds of aminoacid, wherein glycine, alanine and serine accounts for total composition
More than 80%.And fibroin permeability is extremely strong, and moisture-keeping function is preferably, and by cell as alimentation, for its metabolism
Required nutrient is provided, plays the role of to promote skin cell regeneration.
Specific embodiment
Embodiment 1
The preparation of Aloe extraction solution：
Take Aloe, chopping, soaked 1 hour with drinking water, be subsequently adding the cellulase of Aloe weight 1.0%, use salt acid for adjusting pH
It is worth to 5.0, ultrasonic wave added digests 130min；After enzyme digestion reaction, feed liquid is warming up to 90 DEG C, enzyme denaturing 3 minutes, filters, filtrate is standby
With；The filtering residue of gained is extracted twice with ethanol solution：It is heated to micro-boiling, reflux, extract, 2 hours；Filter；Merge filtrate twice,
Concentrating filtrate to relative density after reclaiming ethanol is 1.1, obtains Aloe extraction solution.
The preparation of Bulbus Lilii extracting solution：
Take Bulbus Lilii, in the ethanol solution with the 75% of 10 times of weight, impregnate 60min, surpassed with 3000 power under conditions of 40 DEG C
Sound filters after extracting 30min；Filtering residue again with the 60% of 10 times of weight ethanol solution supersound extraction, condition ibid, filter, merge
Filtrate is standby twice, and it is 1.1 that filtrate is concentrated into relative density, obtains Bulbus Lilii extracting solution.
Preparation for the compositionss of vaginal mucosa anti-inflammation：
（1）After taking Cortex Dictamni 40g, Radix Stemonae 10g, Fructus Zanthoxyli 5g and Fructus Kochiae 20g to be pulverized and mixed, soaked 30 minutes with the water of 750g
Afterwards, then decoct twice, 2 hours every time, filter, it is 1.1 that merging filtrate is concentrated into relative density, must concentrate filtrate standby；
（2）By 40g silk fibroin powder, the nanometer silver solution of 25g1000ppm, 5g benzalkonium bromide, 10g Borneolum Syntheticum, 1g Aloe extraction solution
And 5g Bulbus Lilii extracting solution and step（1）Gained concentrates after filtrate is uniformly mixed and obtains compositionss.
Embodiment 2
The preparation of Aloe extraction solution and Bulbus Lilii extracting solution is with embodiment 1.
Preparation for the compositionss of vaginal mucosa anti-inflammation：
（1）After taking Cortex Dictamni 30g, Radix Stemonae 10g, Fructus Zanthoxyli 5g and Fructus Kochiae 20g to be pulverized and mixed, soaked 30 minutes with the water of 650g
Afterwards, then decoct twice, 2 hours every time, filter, it is 1.1 that merging filtrate is concentrated into relative density, must concentrate filtrate standby；
（2）By 30g silk fibroin powder, the nanometer silver solution of 20g1000ppm, 5g benzalkonium bromide, 5g Borneolum Syntheticum, 1g Aloe extraction solution
And 5g Bulbus Lilii extracting solution and step（1）Gained concentrates after filtrate is uniformly mixed and obtains compositionss.
Embodiment 3
The preparation of Aloe extraction solution and Bulbus Lilii extracting solution is with embodiment 1.
Preparation for the compositionss of vaginal mucosa anti-inflammation：
（1）After taking Cortex Dictamni 50g, Radix Stemonae 20g, Fructus Zanthoxyli 10g and Fructus Kochiae 30g to be pulverized and mixed, soak 30 points with the water of 1100g
Zhong Hou, then decoct twice, 2 hours every time, filter, it is 1.1 that merging filtrate is concentrated into relative density, must concentrate filtrate standby；
（2）50g silk fibroin powder, the nanometer silver solution of 30g1000ppm, 10g benzalkonium bromide, 10g Borneolum Syntheticum, 2g Aloe are extracted
Liquid and 10g Bulbus Lilii extracting solution and step（1）Gained concentrates after filtrate is uniformly mixed and obtains compositionss.
Test example
To test its fungistatic effect from the compositionss for vaginal mucosa anti-inflammation obtained by embodiment 1.
（One）Fungistatic effect
1st, according to GB15979-2002, under test conditions, embodiment 1 products obtained therefrom acts on 2min to escherichia coli, average suppression
Bacterium rate is 99.89%.
Table 1 is to colibacillary fungistatic effect
Positive controls average colony number and scope：6.29×104（4.76 × 104～7.82 × 104）cfu/ml
Negative control Sterile grows.
Conclusion：Embodiment 1 products obtained therefrom has stronger bacteriostasis to escherichia coli.
2nd, according to GB15979-2002, under test conditions, embodiment 1 products obtained therefrom acts on to staphylococcus aureuses
2min, average bacteriostasis rate is 99.90%.
The fungistatic effect of table 2 staphylococcus aureuses
Positive controls average colony number and scope：6.26×104（4.68 × 104～7.84 × 104）cfu/ml
Negative control Sterile grows.
Conclusion：Embodiment 1 products obtained therefrom has stronger bacteriostasis to staphylococcus aureuses.
3rd, according to GB15979-2002, under test conditions, embodiment 1 products obtained therefrom acts on 10min to Candida albicans,
Average bacteriostasis rate is 95.56%.
The fungistatic effect to Candida albicans for the table 3
Positive controls average colony number and scope：6.42×104（4.88 × 104～7.96 × 104）cfu/ml
Negative control Sterile grows.
Conclusion：Embodiment 1 products obtained therefrom has stronger bacteriostasis to Candida albicans.
4th, according to GB15979-2002, under test conditions, embodiment 1 products obtained therefrom acts on to hemolytic group B streptococcus
10min, average bacteriostasis rate is 90.01%.
The fungistatic effect to hemolytic group B streptococcus for the table 4
Positive controls average colony number and scope：5.52×104（4.18 × 104～6.86 × 104）cfu/ml
Negative control Sterile grows.
Conclusion：Embodiment 1 products obtained therefrom has stronger bacteriostasis to hemolytic group B streptococcus.
（Two）Irritant experiment
Embodiment 1 products obtained therefrom is to rabbit vagina mucosa irritation test result
Remarks：The every section of integration=epithelium+leukocyte infiltration+congestion of blood vessel+edema；Every average integral=（A section integration+B section integration
+ C section integrates）/3；Scoring=（No. 1 animal average integral+No. 3 animal average integrals of+No. 2 animal average integrals）/3；Stimulation index
=experimental group average integral-matched group average integral.
Conclusion：Embodiment 1 products obtained therefrom is nonirritant to rabbit vagina mucosa irritation test result.
As can be seen here：Raw material environmental protection of the present invention, process is simple, bacteriostasis are powerful（Bacteriostasis rate up to more than 90%）, but make
With gentle, non-stimulated to skin and mucosa.
Clinical typical case：
1st, Zhang, female, 31 years old, symptom was shown in pruritus vulvae, causalgia, leucorrhea white stiff bean dregs sample, with frequent micturition, dysurea, point
Candida albicans can be found in secretion.With being treated for the compositionss of vaginal mucosa anti-inflammation obtained by embodiment 1,
Once a day, after medication 6 days, clinical symptom disappearance, leucorrhea is normal, and vaginal secretionies check negative.
2nd, Lee, female, 52 years old, symptom was shown in pruritus vulvae, leucorrhea canescence water from washing rice sample, frowziness, and vaginal mucosa color is light red
There is mild hyperaemia, posterior fornix has canescence water from washing rice water sample cystose leucorrhea to gather, in secretions, detect infusorian.Embodiment 1 is made
The compositionss for vaginal mucosa anti-inflammation treated, once a day, after medication 7 days, clinical symptom disappearance, leucorrhea
Normally, vaginal secretionies inspection is feminine gender.
Claims (5)
1. a kind of compositionss for vaginal mucosa anti-inflammation, count by weight ratio, and said composition is made up of following raw material：
Silk fibroin powder 3-5 part, nanometer silver solution 2-3 part of 1000ppm, benzalkonium bromide 0.5-1 part, Cortex Dictamni 3-5 part, the Radix Stemonae
1-2 part, Fructus Zanthoxyli 0.5-1 part, Fructus Kochiae 2-3 part, Borneolum Syntheticum 0.5-1 part, Aloe extraction solution 0.1-0.2 part, Bulbus Lilii extracting solution 0.5-1
Part.
2. compositionss according to claim 1, count by weight ratio, and said composition is made up of following raw material：
4 parts of silk fibroin powder, 2.5 parts of the nanometer silver solution of 1000ppm, 0.5 part of benzalkonium bromide, 4 parts of Cortex Dictamni, 1 part of the Radix Stemonae, river
0.5 part of green pepper, 2 parts of the Fructus Kochiae, 1 part of Borneolum Syntheticum, 0.1 part of Aloe extraction solution, 0.5 part of Bulbus Lilii extracting solution.
3. compositionss according to claim 1 and 2 it is characterised in that：Described Aloe extraction solution is by following preparation method system
?：
Take Aloe, chopping, soak 0.5-1 hour with drinking water, be subsequently adding the cellulase of Aloe weight 0.5-1.0%, use salt
Acid for adjusting pH value digests 15-45min to 4.0-6.0, ultrasonic wave added；After enzyme digestion reaction, feed liquid is warming up to 90-110 DEG C, enzyme denaturing
1-5 minute, filters, and filtrate is standby；The filtering residue of gained is extracted twice with ethanol solution：It is heated to micro-boiling, reflux, extract, 1-2 is little
When；Filter；Merge filtrate twice, concentrating filtrate to relative density after reclaiming ethanol is 1.1-1.2, obtain Aloe and extract
Liquid.
4. compositionss according to claim 1 and 2 it is characterised in that：Described Bulbus Lilii extracting solution is by following preparation method system
?：
Take Bulbus Lilii, with the ethanol solution of the 75-90% of 10 times of weight impregnate 60-90min, under conditions of 40-45 DEG C with
The power ultrasonic of 3000-4000W filters after extracting 30-40min；The ethanol solution with the 60-75% of 10 times of weight is ultrasonic again for filtering residue
Extract, condition ibid, filters, filtrate is standby twice for merging, and it is 1.1-1.2 that filtrate is concentrated into relative density, obtains Bulbus Lilii extracting solution.
5. a kind of preparation method being used for the compositionss of vaginal mucosa anti-inflammation as claimed in claim 1 or 2, its feature exists
Comprise the following steps in the method：
（1）Measure after Cortex Dictamni, the Radix Stemonae, Fructus Zanthoxyli and the Fructus Kochiae be pulverized and mixed by formula, with 10 times of its four Chinese medicine gross weight
After water soaks 30 minutes, then decoct twice, 2 hours every time, filter, merging filtrate be concentrated into relative density obtain for 1.1-1.2 dense
Contracting filtrate is standby；
（2）By the silk fibroin powder of formula ratio, the nanometer silver solution of 1000ppm, benzalkonium bromide, Borneolum Syntheticum, Aloe extraction solution and
Bulbus Lilii extracting solution and step（1）Gained concentrates after filtrate is uniformly mixed and obtains compositionss.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232605.9A CN106421575A (en) | 2016-12-28 | 2016-12-28 | Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611232605.9A CN106421575A (en) | 2016-12-28 | 2016-12-28 | Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421575A true CN106421575A (en) | 2017-02-22 |
Family
ID=58215493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611232605.9A Withdrawn CN106421575A (en) | 2016-12-28 | 2016-12-28 | Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106421575A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309750A (en) * | 2011-04-15 | 2012-01-11 | 深圳市宜丽环保科技有限公司 | A kind of conditioning health preserving film that is exclusively used in women's privates |
| CN104667021A (en) * | 2015-03-24 | 2015-06-03 | 福建天斯顿生物科技有限公司 | Compound product containing bamboo leaf flavonoid and preparation method thereof |
| CN104984196A (en) * | 2015-07-15 | 2015-10-21 | 四川默森药业有限公司 | Antibacterial composition containing cortex dictamni and preparation method thereof |
| CN104997917A (en) * | 2015-05-07 | 2015-10-28 | 湖州品创孵化器有限公司 | Gynecological traditional Chinese medicine composition containing nano-silver |
| CN105169153A (en) * | 2015-08-27 | 2015-12-23 | 浙江苏泊尔南洋药业有限公司 | Dampness removing and parasite destroying traditional Chinese medicine composition and preparation method thereof |
| CN105267118A (en) * | 2015-10-28 | 2016-01-27 | 皖南医学院 | Whitening and moisturizing essence containing natural ingredient extract and preparation method and application of essence |
| CN106038629A (en) * | 2016-05-09 | 2016-10-26 | 南京泽朗医药科技有限公司 | A preparing method of globe amaranth volatile oil and applications of the volatile oil |
-
2016
- 2016-12-28 CN CN201611232605.9A patent/CN106421575A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309750A (en) * | 2011-04-15 | 2012-01-11 | 深圳市宜丽环保科技有限公司 | A kind of conditioning health preserving film that is exclusively used in women's privates |
| CN104667021A (en) * | 2015-03-24 | 2015-06-03 | 福建天斯顿生物科技有限公司 | Compound product containing bamboo leaf flavonoid and preparation method thereof |
| CN104997917A (en) * | 2015-05-07 | 2015-10-28 | 湖州品创孵化器有限公司 | Gynecological traditional Chinese medicine composition containing nano-silver |
| CN104984196A (en) * | 2015-07-15 | 2015-10-21 | 四川默森药业有限公司 | Antibacterial composition containing cortex dictamni and preparation method thereof |
| CN105169153A (en) * | 2015-08-27 | 2015-12-23 | 浙江苏泊尔南洋药业有限公司 | Dampness removing and parasite destroying traditional Chinese medicine composition and preparation method thereof |
| CN105267118A (en) * | 2015-10-28 | 2016-01-27 | 皖南医学院 | Whitening and moisturizing essence containing natural ingredient extract and preparation method and application of essence |
| CN106038629A (en) * | 2016-05-09 | 2016-10-26 | 南京泽朗医药科技有限公司 | A preparing method of globe amaranth volatile oil and applications of the volatile oil |
Non-Patent Citations (1)
| Title |
|---|
| 刘世军: "《农业科技产业发展理论与实践》", 31 December 2008, 中国农业科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107510768A (en) | A kind of draft bacteriostatic gel | |
| CN101524499A (en) | Gynecological lotion and preparation method thereof | |
| CN103007124B (en) | Chinese medicine preparation for treating gynecologic inflammation | |
| CN102949501A (en) | External washing lotion for treating gynecological inflammation | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN104623218A (en) | Traditional Chinese medicine facial mask for treating acne and preparation method thereof | |
| CN102205077B (en) | Gynecopathy external use washing lotion and preparation method thereof | |
| CN102018807A (en) | Medicine composition for treating gynaecologic trichomonas vaginitis and preparation method thereof | |
| CN103239676B (en) | Topical pharmaceutical composition for preventing and treating bacterial vaginosis | |
| CN102755578B (en) | Washing liquid for treating gynecologic diseases and preparation method thereof | |
| CN102988844A (en) | Gynaecological gel and extraction method thereof | |
| CN104288552A (en) | Vagina-cleaning care solution and preparation method thereof | |
| CN105535723A (en) | Traditional Chinese medicinal composition for treating vulvitis and external preparation of traditional Chinese medicinal composition | |
| CN104587033B (en) | A kind of Nano Silver rhinitis ointment | |
| CN105106304A (en) | Traditional Chinese medicine compound preparation for treating gynecological inflammations and preparation method thereof | |
| CN109966357A (en) | A kind of Traditional Chinese medicine micro-ecological compound preparation and its preparation method and application | |
| CN106421575A (en) | Composition for antisepsis and anti-inflammation of vagina mucosas and preparation method of composition | |
| CN1125599A (en) | Composition of external-use medicine for improving skin and gynecology and its manufacture method | |
| CN107536923A (en) | A kind of oldenlandia diffusa antibacterial gel | |
| CN102078546A (en) | Gynecological medical lotion for external use | |
| CN102462768A (en) | Female nursing solution for external use | |
| CN1075382C (en) | Medicinal ice for oral cavity and preparing process thereof | |
| CN108578614A (en) | A kind of draft nursing gel for having effects that sterilization and compacting | |
| CN101934040A (en) | Natural-component vagina cleaning lotion and preparation method thereof | |
| CN106177271A (en) | A kind of conditioning liquid for cleaning containing plant extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170222 |
|
| WW01 | Invention patent application withdrawn after publication |