CN106421522A - Special medicinal preparation for preventing and treating dairy cow mastitis - Google Patents

Abstract

The invention discloses a special medicinal preparation for preventing and treating dairy cow mastitis, belonging to the field of medicines. The special medicinal preparation is prepared from the following raw materials: honeysuckle flowers, discolor cinquefoil herb with root, rhizoma ligustici, semen coicis, nux prinsepiae, radix scutellariae, spina date seeds, semen torreya, folium polygoni tinctorll, kadsurae caulis, herba epimedii, herba leonuri, dried tangerine or orange peel and catechu. The prepared medicinal preparation has very good treatment effects for dairy cow mastitis, the effective rate achieves 99% or above, the body constitution of the dairy cow can be improved, the quality and yield of dairy products can be improved, no residue is caused, the special medicinal preparation also can be added in daily fodder for preventing mastitis, and therefore, the special medicinal preparation has a very good use value.

Description

A kind of preventing and treating mammitis of cow special agent

Technical field

The invention belongs to drug world is and in particular to a kind of prevent and treat mammitis of cow special agent.

Background technology

Mastitiss, particularly recessive mastitis are a kind of very high cystic hyperplasia of breast of Lactation of Dairy Cow phase sickness rate, can make to suffer from cattle Lactogenic function and giving milk drastically declines, and causes milch cow Reproductive Performance to lack of proper care, becomes commonly encountered diseases and the frequently-occurring disease of vast cattle farm, sternly Govern the development of dairy again.According to statistics, there are mastitiss in milch cow, and milk yield averagely declines 8%, and the lighter declines 5%, Severe one is up to 25%～40%.Infected in the cow at least Ge Ru area of the U.S. 30% ~ 70%, every year because of the generation of primary disease, damage Fail to keep an appointment 2,000,000,000 dollars, Japan reaches 500,000,000 dollars.The incidence rate of China's mammitis of cow is higher, and the survey showed that for Yuan Yonglong etc., faces Bed-type mastitiss sickness rate average out to 33.41%, latent mammitises average positive rate is 73.91%, and newborn room prevalence is 44.74%. All over the world antibiotic is listed in the choice drug for the treatment of mastitiss in decades, due to being repeatedly used for a long, bringing one is Row problem, such as Resistant strain increase, and endocrine dysfunction, antibiotic remainss and residue of veterinary drug are exceeded etc., badly influence people Class health.With consumers in general, more and more higher is required to milk quality, propose antibiotic-free milk, the demand cry of noresidue milk is also healed Send out strong.

Currently for the generation of mastitiss, conventional Therapeutic Method has：Su Jie penicillin, the room injection of streptomycin breast combine GONGYINGSAN for oral administration and Adlerika hot compress breast affected part, treat Mammitis of cattle, achieve good therapeutic effect.In Li Peilin etc. Western medicine preparation thin sulfur cream breast application is treated acute mammitis of cow and is all cured.Ma Shudong etc. uses breast Sweeling-eliminating medicine powder to take orally, First treat 153 in conjunction with specially good effect rice, cure rate is 85.6%.Lin Zhenxiang is using chaste tree anti-Fructus Arctii soup, externally applied herbal medicine for oral administration, papillary duct The methods such as injection of antibiotics treat milch cow clinic mastitis 66, cure rate 84.3%, and effective percentage is 95.3%.Gu Huijuan etc. sends out Existing Chinese-western medicine preparation " strength is raw " is better than single levamisole to the therapeutic effect of bovine subclinical mastitis.Zhu Guangdao etc. uses Chinese medicine Compound recipe, single Herba Taraxaci, gentamycin sulfate and procaine hydrochloride, Houhai acupoint injection and levamisole hydrochloride cooperation Herba Houttuyniae 4 kinds of methods of injection intramuscular injection treat latent mammitises, and result shows levamisole cooperation Herba Houttuyniae injectio intramuscular injection And Chinese medicine compound is to treat this sick best approach.

At present for the treatment of this disease of mastitiss, mostly it be unable to do without the auxiliary of Western medicine, and existing therapeutic scheme meeting More or less have influence on the quality and yield of Lac Bovis seu Bubali.

Content of the invention

The present invention is intended to provide a kind of preventing and treating mammitis of cow special agent, on the basis of numerous studies, by reasonable Collocation pure Chinese herbal medicine composition is made, and has good preventive and therapeutic effect to mastitiss, and safe noresidue, ensure that milk well Yield and quality.

The present invention is achieved through the following technical solutions：

A kind of preventing and treating mammitis of cow special agent, is made up of the material of following weight portion：

13 ~ 15 portions of Flos Loniceraes, 7 ~ 9 parts of Herba Potentillae Discoloris, 6 ~ 8 parts of Rhizoma Ligusticis, 4 ~ 7 parts of Semen Coiciss, 3 ~ 6 parts of Nux Prinsepiae, 8 ~ 13 parts of Radix Scutellariaes, 6 ~ 9 Part Semen Ziziphi Spinosae, 4 ~ 6 portions of Semen Torreyaes, 8 ~ 10 parts of Liao Folium Isatidiss, 3 ~ 5 parts of Yunnan Caulis Spatholobis, 2 ~ 5 parts of Herba Epimedii, 3 ~ 4 parts of Herba Leonuris, 4 ~ 6 parts Pericarpium Citri Reticulatae, 6 ~ 8 share tea.

A kind of preparation method of preventing and treating mammitis of cow special agent, comprises the steps：

（1）By Flos Lonicerae, Herba Potentillae Discoloris, Rhizoma Ligustici, Semen Coiciss, Nux Prinsepiae, Radix Scutellariae, Semen Ziziphi Spinosae, Semen Torreyae, Liao Folium Isatidiss, Yunnan Caulis Spatholobi, excessive The sheep leaves of pulse plants, Herba Leonuri, Pericarpium Citri Reticulatae and catechu are put in the salt solution that the mass fraction boiling is 6% jointly, after immersion treatment 3 ~ 4min Take out, dry standby；

（2）By step（1）After Flos Lonicerae after middle process, Herba Potentillae Discoloris, Liao Folium Isatidiss, Herba Leonuri mix jointly, put into and fill wheat In the marmite of bran, keeping temperature is 80 ~ 85 DEG C, and after the process 11 ~ 13min that constantly stir-fries, it is standby that taking-up elimination Testa Tritici obtains parch medicine A With；

（3）By step（1）After the common mixing of Semen Coiciss after middle process, Nux Prinsepiae, Semen Ziziphi Spinosae, Semen Torreyae, put into and fill yellow soil In marmite, keeping temperature is 94 ~ 98 DEG C, and after the process 14 ~ 17min that constantly stir-fries, it is standby that taking-up elimination yellow soil obtains parch medicine B；

（4）By step（1）After Rhizoma Ligustici after middle process, Radix Scutellariae, Yunnan Caulis Spatholobi, Herba Epimedii, Pericarpium Citri Reticulatae and the common mixing of catechu, put into Fill in the marmite of Semen setariae, keeping temperature is 105 ~ 109 DEG C, after the process 18 ~ 20min that constantly stir-fries, take out elimination Semen setariae and must fry Pharmacy C is standby；

（5）By above-mentioned steps, the parch medicine A being obtained, parch medicine B, the common co-grinding of parch medicine C are crossed after 60 mesh, then with its total matter Measure 3 ~ 4 times of clear water blending, and heat boiling and boil 30 ~ 40min, filter to obtain first-time filtrate, add proper mass identical clear water again Afterwards, continue heating boiling and boil 40 ~ 50min, filter to obtain secondary filtrate, merge filtrate twice, be finally concentrated into the 1/8 ~ 1/9 of original volume ?.

Further, step（5）Described in when heating boiling twice and boiling process, constantly entered with 100 ~ 120 revs/min of rotating speed Row stirring operation.

The present invention has the advantages that：

On the basis of numerous studies, in conjunction with the compatibility theory of Traditional chinese medicine medicament, reasonably combined corresponding Chinese herbal medicine becomes the present invention Point, the then physical property according to different pharmaceutical composition, carry out corresponding parch process before water extraction, that is, serve removal partly poisonous Harmful components, improve the effect taking palatability, can strengthen its drug effect again, are easy to extract operation.The medicament being finally obtained is to milk Mammitis of cattle has good curative effect, effective percentage up to more than 99%, and can improve the body body constitution of milch cow, strengthens milk Quality and yield, does not result in any residual, also can be added in daily feedstuff, for preventing the generation of mastitiss, has very well Use value.

Specific embodiment

Embodiment 1

A kind of preventing and treating mammitis of cow special agent, is made up of the material of following weight portion：

13 portions of Flos Loniceraes, 7 parts of Herba Potentillae Discoloris, 6 parts of Rhizoma Ligusticis, 4 parts of Semen Coiciss, 3 parts of Nux Prinsepiae, 8 parts of Radix Scutellariaes, 6 parts of Semen Ziziphi Spinosaes, 4 portions of Semen Torreyaes, 8 parts of Liao Folium Isatidiss, 3 parts of Yunnan Caulis Spatholobis, 2 parts of Herba Epimedii, 3 parts of Herba Leonuris, 4 parts of Pericarpium Citri Reticulataes, 6 share tea.

A kind of preparation method of preventing and treating mammitis of cow special agent, comprises the steps：

（1）By Flos Lonicerae, Herba Potentillae Discoloris, Rhizoma Ligustici, Semen Coiciss, Nux Prinsepiae, Radix Scutellariae, Semen Ziziphi Spinosae, Semen Torreyae, Liao Folium Isatidiss, Yunnan Caulis Spatholobi, excessive The sheep leaves of pulse plants, Herba Leonuri, Pericarpium Citri Reticulatae and catechu are put in the salt solution that the mass fraction boiling is 6% jointly, take after immersion treatment 3min Go out, dry standby；

（2）By step（1）After Flos Lonicerae after middle process, Herba Potentillae Discoloris, Liao Folium Isatidiss, Herba Leonuri mix jointly, put into and fill wheat In the marmite of bran, keeping temperature is 82 DEG C, and after the process 12min that constantly stir-fries, it is standby that taking-up elimination Testa Tritici obtains parch medicine A；

（3）By step（1）After the common mixing of Semen Coiciss after middle process, Nux Prinsepiae, Semen Ziziphi Spinosae, Semen Torreyae, put into and fill yellow soil In marmite, keeping temperature is 97 DEG C, and after the process 15min that constantly stir-fries, it is standby that taking-up elimination yellow soil obtains parch medicine B；

（4）By step（1）After Rhizoma Ligustici after middle process, Radix Scutellariae, Yunnan Caulis Spatholobi, Herba Epimedii, Pericarpium Citri Reticulatae and the common mixing of catechu, put into Fill in the marmite of Semen setariae, keeping temperature is 107 DEG C, after the process 19min that constantly stir-fries, it is standby that taking-up elimination Semen setariae obtains parch medicine C With；

（5）By above-mentioned steps, the parch medicine A being obtained, parch medicine B, the common co-grinding of parch medicine C are crossed after 60 mesh, then with its total matter Measure 3 times of clear water blending, and heat boiling and boil 35min, filter to obtain first-time filtrate, after adding proper mass identical clear water again, continue 45min is boiled in continuous heating boiling, filters to obtain secondary filtrate, merges filtrate twice, be finally concentrated into the 1/8 of original volume.

Further, step（5）Described in when heating boiling twice and boiling process, constantly stirred with 110 revs/min of rotating speed Mix operation.

Embodiment 2

A kind of preventing and treating mammitis of cow special agent, is made up of the material of following weight portion：

14 portions of Flos Loniceraes, 8 portions of Herba Potentillae Discoloris, 7 portions of Rhizoma Ligusticis, 5 portions of Semen Coiciss, 4 portions of Nux Prinsepiae, 10 portions of Radix Scutellariaes, 8 portions of Semen Ziziphi Spinosaes, 5 portions of Chinese torreyas Son, 9 parts of Liao Folium Isatidiss, 4 parts of Yunnan Caulis Spatholobis, 3 parts of Herba Epimedii, 3 parts of Herba Leonuris, 5 parts of Pericarpium Citri Reticulataes, 7 share tea.Remaining method and enforcement Example 1 is identical.

Embodiment 3

A kind of preventing and treating mammitis of cow special agent, is made up of the material of following weight portion：

15 portions of Flos Loniceraes, 9 portions of Herba Potentillae Discoloris, 8 portions of Rhizoma Ligusticis, 7 portions of Semen Coiciss, 6 portions of Nux Prinsepiae, 13 portions of Radix Scutellariaes, 9 portions of Semen Ziziphi Spinosaes, 6 portions of Chinese torreyas Son, 10 parts of Liao Folium Isatidiss, 5 parts of Yunnan Caulis Spatholobis, 5 parts of Herba Epimedii, 4 parts of Herba Leonuris, 6 parts of Pericarpium Citri Reticulataes, 8 share tea.Remaining method and reality Apply example 1 identical.

Comparative example 1

This comparative example 1 compared with Example 1, does not carry out corresponding parch process, in the preparation only in accordance with conventional method Carry out decocting in water extraction and make medicine.

Matched group

Existing inflammation RJN thing.

In order to contrast effect of the present invention, from the close holstein cow with mastitiss of parity, milk yield, random point For five groups, carry out feeding treatment, every daily feeding 45 ~ 50ml respectively with above-mentioned medicine, table 1 below is corresponding contrast number According to：

Table 1

	Cure rate（%）	Effective percentage（%）	Average daily milk yield after healing（Kg/ head）
				Embodiment 1	91.4	99.3	26.23±1.5
Embodiment 2	91.6	100	26.58±1.7
				Embodiment 3	91.2	99.5	26.09±1.2
Comparative example 1	87.3	97.7	22.42±1.3
				Matched group	85.8	95.6	18.37±1.0

By upper table 1 as can be seen that the medicament that the present invention is obtained has good curative effect for mastitiss, and milch cow can be improved Milk yield.

In order to contrast effect of the present invention further, the milch cow after embodiment 2, comparative example 1, matched group healing is produced Milk matter is detected, table 2 below is corresponding correction data：

Table 2

	Embodiment 2	Comparative example 1	Matched group
				Content of milk protein（%）	3.37±0.13	3.22±0.09	3.16±0.08
Milk fat content（%）	3.74±0.16	3.45±0.12	3.31±0.16
				Lactose content（%）	5.33±0.16	5.14±0.14	5.09±0.11
Non-fat solid content（%）	9.22±0.25	9.06±0.20	8.91±0.18

By upper table 2 as can be seen that medicament of the present invention can improve the dairy food quality of milch cow well hence it is evident that improving disease for milk The infringement of cattle body constitution, improves culture benefit.

Claims (3)

1. a kind of preventing and treating mammitis of cow special agent is it is characterised in that be made up of the material of following weight portion：

13 ~ 15 portions of Flos Loniceraes, 7 ~ 9 parts of Herba Potentillae Discoloris, 6 ~ 8 parts of Rhizoma Ligusticis, 4 ~ 7 parts of Semen Coiciss, 3 ~ 6 parts of Nux Prinsepiae, 8 ~ 13 parts of Radix Scutellariaes, 6 ~ 9 Part Semen Ziziphi Spinosae, 4 ~ 6 portions of Semen Torreyaes, 8 ~ 10 parts of Liao Folium Isatidiss, 3 ~ 5 parts of Yunnan Caulis Spatholobis, 2 ~ 5 parts of Herba Epimedii, 3 ~ 4 parts of Herba Leonuris, 4 ~ 6 parts Pericarpium Citri Reticulatae, 6 ~ 8 share tea.

2. a kind of as claimed in claim 1 preventing and treating mammitis of cow special agent preparation method it is characterised in that include as Lower step：

（1）By Flos Lonicerae, Herba Potentillae Discoloris, Rhizoma Ligustici, Semen Coiciss, Nux Prinsepiae, Radix Scutellariae, Semen Ziziphi Spinosae, Semen Torreyae, Liao Folium Isatidiss, Yunnan Caulis Spatholobi, excessive The sheep leaves of pulse plants, Herba Leonuri, Pericarpium Citri Reticulatae and catechu are put in the salt solution that the mass fraction boiling is 6% jointly, after immersion treatment 3 ~ 4min Take out, dry standby；

（2）By step（1）After Flos Lonicerae after middle process, Herba Potentillae Discoloris, Liao Folium Isatidiss, Herba Leonuri mix jointly, put into and fill wheat In the marmite of bran, keeping temperature is 80 ~ 85 DEG C, and after the process 11 ~ 13min that constantly stir-fries, it is standby that taking-up elimination Testa Tritici obtains parch medicine A With；

（3）By step（1）After the common mixing of Semen Coiciss after middle process, Nux Prinsepiae, Semen Ziziphi Spinosae, Semen Torreyae, put into and fill yellow soil In marmite, keeping temperature is 94 ~ 98 DEG C, and after the process 14 ~ 17min that constantly stir-fries, it is standby that taking-up elimination yellow soil obtains parch medicine B；

（4）By step（1）After Rhizoma Ligustici after middle process, Radix Scutellariae, Yunnan Caulis Spatholobi, Herba Epimedii, Pericarpium Citri Reticulatae and the common mixing of catechu, put into Fill in the marmite of Semen setariae, keeping temperature is 105 ~ 109 DEG C, after the process 18 ~ 20min that constantly stir-fries, take out elimination Semen setariae and must fry Pharmacy C is standby；

（5）By above-mentioned steps, the parch medicine A being obtained, parch medicine B, the common co-grinding of parch medicine C are crossed after 60 mesh, then with its total matter Measure 3 ~ 4 times of clear water blending, and heat boiling and boil 30 ~ 40min, filter to obtain first-time filtrate, add proper mass identical clear water again Afterwards, continue heating boiling and boil 40 ~ 50min, filter to obtain secondary filtrate, merge filtrate twice, be finally concentrated into the 1/8 ~ 1/9 of original volume ?.

3. a kind of preparation method of preventing and treating mammitis of cow special agent according to claim 2 is it is characterised in that step （5）Described in when heating boiling twice and boiling process, be constantly stirred operating with 100 ~ 120 revs/min of rotating speed.