CN106421307A - Heat stress resistant agent used for chicken and preparation method thereof - Google Patents
Heat stress resistant agent used for chicken and preparation method thereof Download PDFInfo
- Publication number
- CN106421307A CN106421307A CN201610941025.0A CN201610941025A CN106421307A CN 106421307 A CN106421307 A CN 106421307A CN 201610941025 A CN201610941025 A CN 201610941025A CN 106421307 A CN106421307 A CN 106421307A
- Authority
- CN
- China
- Prior art keywords
- heat stress
- chicken
- chinese medicine
- stress agent
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000008642 heat stress Effects 0.000 title abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 60
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 34
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 17
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 17
- 229940046009 vitamin E Drugs 0.000 claims abstract description 17
- 239000011709 vitamin E Substances 0.000 claims abstract description 17
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims abstract description 11
- 235000010331 calcium propionate Nutrition 0.000 claims abstract description 11
- 239000004330 calcium propionate Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 241000628997 Flos Species 0.000 claims description 18
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 18
- 229930182816 L-glutamine Natural products 0.000 claims description 16
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 229940125773 compound 10 Drugs 0.000 claims description 2
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 230000035882 stress Effects 0.000 abstract description 51
- 230000000694 effects Effects 0.000 abstract description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 6
- 235000021050 feed intake Nutrition 0.000 abstract description 5
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 210000004698 lymphocyte Anatomy 0.000 abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract description 3
- 238000001243 protein synthesis Methods 0.000 abstract description 3
- 230000014616 translation Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000002496 gastric effect Effects 0.000 abstract description 2
- 239000012528 membrane Substances 0.000 abstract description 2
- 235000019629 palatability Nutrition 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 241000605445 Anemarrhena asphodeloides Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000002535 acidifier Substances 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 7
- 230000036541 health Effects 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000003969 glutathione Nutrition 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007084 physiological dysfunction Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000004665 defense response Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to the technical field of heat stress resistance and in particular relates to a heat stress resistant agent used for chicken and a preparation method thereof. The agent comprises the following raw materials in parts by weight: 15-20 parts of gypsum, 15-20 parts of honeysuckle flower, 10-15 parts of common anemarrhena rhizome, 15-20 parts of liquorice root, 0.1-0.5 part of vitamin E and 5-20 parts of glutamine. The heat stress resistant agent has the beneficial effects that the heat stress resistant agent is convenient to use and only needs to be mixed in feeds; through addition of the traditional Chinese medicines with the function of clearing away heat and toxic materials and glutamine, heat stress of chicken is effectively improved, organism metabolism and nitrogen balance are improved, protein synthesis is promoted, the total amount of lymphocytes is increased, the feed intake of chicken at high temperature is effectively increased and the laying rate is increased; an acidifier formed by citric acid, calcium propionate and hawthorn fruit has the effects of regulating the PH value of the stress agent, stimulating digestive absorption of gastrointestinal membranes of chicken and improving the palatability of feeds; calcium propionate is a good mildew preventive and has the effect of effectively lengthening the storage periods of the feeds.
Description
Technical field
The present invention relates to anti-heat stress technical field is and in particular to breeder anti-heat stress agent and preparation method thereof.
Background technology
Heat stress refers to the physiological reaction to the nonspecific defense response of heat stress source for the animal body, and high temperature is impact poultry
One of the essential environmental factors producing, different from other domestic animals, it is vigorous that chicken has a metabolism, and fever does not have the life of sweat gland
Reason feature, to high temperature tolerance low degree, once hen house temperature is more than 30 DEG C, will strong heat stress state in chicken group.?
South China area, 32 DEG C of summer average daily temperature, maximum temperature is up to 35～38 DEG C.Highdensity yard feeding pattern is in addition high damp and hot
Breeding environment, increased the thermal stress reaction of chicken, be mainly shown as physiological dysfunction, feed intake and production performance decline,
Meat quality reduce, serious when lead to death, provisions chicken Producer causes very big economic loss.Therefore, how to reduce heat should
Swash the negative effect that brings, be poultry Producer must faced by practical problem.
Content of the invention
The present invention is to solve above-mentioned technical problem, there is provided breeder anti-heat stress agent and preparation method thereof.
To realize particular by technical scheme below：
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 15～20, Flos Lonicerae 15～
20th, the Rhizoma Anemarrhenae 10～15, Radix Glycyrrhizae 15～20, Vitamin E 0.1～0.5, L-Glutamine 5～20.
Preferably, comprise following raw material by weight：Gypsum Fibrosum 18, Flos Lonicerae 18, the Rhizoma Anemarrhenae 13, Radix Glycyrrhizae 18, dimension life
Plain E0.3, L-Glutamine 13.
Further, chicken also includes acidulant with anti-heat stress agent, is by 1: 0.7～1.1 by citric acid, calcium propionate and Fructus Crataegi
: 3～5 mass ratio mixing, addition is the pH value adjusting anti-heat stress agent to 5.5～6.
Further, chicken anti-heat stress agent, its preparation method comprises the following steps：By Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae respectively
Mix after cleaning, obtain Chinese medicine compound, add the ethanol that concentration is 15～20%, soak Chinese medicine compound 10～15min, pull out
Drain, add the water of 4～5 times of Chinese medicine compound, decoct, keep slight boiling condition 2～2.5h, filter, filtrate adds filtrate
The Sal of the 4～7% of quality, stirs 60～70min at 60～80 DEG C, obtains Chinese medical concrete, and it is 5 that filtering residue is dried to water content
～7%, pulverized 80 mesh sieves, obtained Chinese medicine powder, under 80～90 DEG C of water bath with thermostatic control environment, by Chinese medicine powder, Chinese medical concrete, calculogenesis
Cream mixes, and stir-fry 5～8min, adds Vitamin E, L-Glutamine, mix, dry, pulverize 80 mesh sieves after being cooled to room temperature, plus
Enter acidulant, adjust PH.
Further, this anti-heat stress agent, takes in the morning and evening, and each takes, and anti-heat stress agent and chicken feed are pressed
0.08～0.12: 1 mass ratio mixing.
The raw material that the present invention adopts, has following effect：
Gypsum Fibrosum：Clearing away heat-fire, relieving restlessness is quenched the thirst, and restrains granulation promoting, cures mainly apoplexy cold and heat, and heart subinverse gas is frightened to be breathed heavily, xerostomia scorching tongue,
Hardness and fullness in the abdomen pain, fever of the body of having a headache, three Jiao are hot greatly, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis.
Flos Lonicerae：Its effect is mainly heat-clearing and toxic substances removing, cures mainly warm disease heating, toxic-heat and blood stasis, carbuncle furunculosis etc..
The Rhizoma Anemarrhenae：Clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, cure mainly pyreticosis polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dryness of the intestine is just
Secret.
Radix Glycyrrhizae：With Flos Lonicerae with using, there is heat-clearing and toxic substances removing.
L-Glutamine：L-Glutamine has important immunoregulation effect, and it is lymphocytic emiocytosis, propagation and its function
Remain necessary, organism metabolism, nitrogen balance can be improved, promote protein synthesis, increase total lymphocyte count, as a kind of anti-
Oxidant, participates in synthesizing glutathion, and Glutathione has wide spectrum removing toxic substances, the effect of enhancing immunity, is animal stress
Under the conditions of a kind of required important regulating and controlling factor.
Vitamin E：There are different physiological roles, as natural fat-soluble chain breaking antioxidants, can stop intracellular not
Saturation lipid oxidation, protects cell membrane from oxidative damage, maintains cell integrity.
Below effect experiment is further illustrated to the curative effect of the present invention
1st, anti-heat stress agent toxicity test research of the present invention
Subjects：Choose the white mice 100 of health health, male and female half and half, body weight 12～18g, shine artificial
Breeding observing 2d under bright 24h, ventilation condition good situations, is randomly divided into 5 groups, the front 12h of administration and administration forbid within latter 4 hours into
Food, but can't help water, one of which is blank examination group.
Test method：After 2d, except blank group respectively other 4 groups of white mice are gavaged dosage be respectively 0.02mg/g,
The Chinese medicine composition of 0.04mg/g, 0.06mg/g, 0.08mg/g, matched group white mouse does not feed the present composition, observe 15～
20d.
Result：All white mice is all good for the aspects such as alive and all white mice spirit, appetite, secretions, breathing, eye all not
Observe exception, and compare with matched group without exception, illustrate this anti-heat stress agent to mice safety non-toxic.
2nd, anti-heat stress agent of the present invention is studied to heat stress therapeutic test
Subjects：Choose the white mice 200 of health health, male and female half and half, body weight 20～25g, shine artificial
Breeding observing 2d under bright 24h, ventilation condition good situations, the front 12h of administration and administration are forbidden taking food for latter 4 hours, but can't help water, with
Machine is divided into 2 groups, and one of which is blank examination group.
Test method：After 2d, adjust indoor temperature at 30～33 DEG C, 50～60%, test group gavages relative humidity
Anti-heat stress agent of the present invention, matched group gavages the medicine of the treatment heat stress of routine, sooner or later gavages once daily, each consumption is
0.02～0.06ml/g, takes the survival rate to two groups of white mice after 10～15d, the mental status, relapse rate afterwards are united
Meter, result is as shown in table 1：
Table 1
3rd, the clinical research to chicken is tested
(1), physiological dysfunction, feed intake and production performance decline, dead phenomenon in certain chicken house cage Young cock,
Using anti-heat stress agent of the present invention, after 4～6d, effectively raise feed intake, the daily gain of Young cock, meanwhile, after taking,
The situation of illness does not occur in later stage cultivation, compared to traditional stress agent, though taking rear energy relief of symptoms, suffering from occurs in the later stage
The situation of disease, stress agent of the present invention enhances the immunocompetence of chicken, thus improving the anti-heat stress ability of chicken, to whole chicken house
The Cure of heat stress is counted, and cure rate is 96.5%.
In sum, the beneficial effects of the present invention is：The present invention easy to use it is only necessary to admix in feedstuff, lead to
Cross the Chinese medicine with heat-clearing and toxic substances removing, and the addition of L-Glutamine, be effectively improved the heat stress situation of chicken, improve organism metabolism,
Nitrogen balance, promotion protein synthesis, increase total lymphocyte count, effectively improve the feed intake of chicken and raising laying rate under high temperature；
The acidulant being made up of citric acid, calcium propionate and Fructus Crataegi, adjusts the pH value of stress agent, stimulates digesting and assimilating of chicken gastrointestinal membranes, carries
The palatability of high feedstuff, wherein calcium propionate are good antifungus agents, effectively extend the storage period of feedstuff.
Specific embodiment
Below the specific embodiment of the present invention is described in further detail, but the invention is not limited in that these are real
Apply mode, the improvement on any essence spirit in the present embodiment or replacement, still fall within the claims in the present invention required for protection
Scope.
Embodiment 1
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 15g, Flos Lonicerae 15g, the Rhizoma Anemarrhenae
10～15g, Radix Glycyrrhizae 15g, Vitamin E 0.1g, L-Glutamine 5g.
Chicken also includes acidulant with anti-heat stress agent, is to be mixed by 1: 0.7: 3 mass ratio by citric acid, calcium propionate and Fructus Crataegi
Close, addition is the pH value adjusting anti-heat stress agent to 5.5.
Chicken anti-heat stress agent, its preparation method comprises the following steps：It is mixed after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively
Close, obtain Chinese medicine compound, add the ethanol that concentration is 15%, soak Chinese medicine compound 10min, pull out and drain, add Chinese medicine to mix
Close the water of 4 times of material, decoct, keep slight boiling condition 2h, filter, filtrate adds the 4% of filtrate quality Sal, at 60 DEG C
Stirring 60min, obtains Chinese medical concrete, and it is 5% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, in 80 DEG C of perseverance
Under tepidarium environment, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 5min, adds Vitamin E, paddy after being cooled to room temperature
Glutamine, mixes, and dry, pulverize 80 mesh sieves, adds acidulant, adjusts PH.
The agent of this anti-heat stress, takes in the morning and evening, and each takes, and anti-heat stress agent is pressed 0.08 with chicken feed：1 matter
Amount is than mixing.
Embodiment 2
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 20g, Flos Lonicerae 20g, the Rhizoma Anemarrhenae
15g, Radix Glycyrrhizae 20g, Vitamin E 0.5g, L-Glutamine 20g.
Chicken also includes acidulant with anti-heat stress agent, is to be mixed by 1: 1.1: 5 mass ratio by citric acid, calcium propionate and Fructus Crataegi
Close, addition is the pH value adjusting anti-heat stress agent to 6.
Chicken anti-heat stress agent, its preparation method comprises the following steps：It is mixed after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively
Close, obtain Chinese medicine compound, add the ethanol that concentration is 20%, soak Chinese medicine compound 15min, pull out and drain, add Chinese medicine to mix
Close the water of 5 times of material, decoct, keep slight boiling condition 2.5h, filter, filtrate adds the 7% of filtrate quality Sal, at 80 DEG C
Lower stirring 70min, obtains Chinese medical concrete, and it is 7% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, at 90 DEG C
Under water bath with thermostatic control environment, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 8min, be cooled to after room temperature add Vitamin E,
L-Glutamine, mixes, and dry, pulverize 80 mesh sieves, adds acidulant, adjusts PH.
The agent of this anti-heat stress, takes in the morning and evening, and each takes, and anti-heat stress agent and chicken feed is pressed 0.12: 1 matter
Amount is than mixing.
Embodiment 3
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 18g, Flos Lonicerae 18g, the Rhizoma Anemarrhenae
13g, Radix Glycyrrhizae 18g, Vitamin E 0.3g, L-Glutamine 13g.
Chicken also includes acidulant with anti-heat stress agent, is to be mixed by 1: 0.9: 4 mass ratio by citric acid, calcium propionate and Fructus Crataegi
Close, addition is the pH value adjusting anti-heat stress agent to 5.8.
Chicken anti-heat stress agent, its preparation method comprises the following steps：It is mixed after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively
Close, obtain Chinese medicine compound, add the ethanol that concentration is 18%, soak Chinese medicine compound 13min, pull out and drain, add Chinese medicine to mix
Close the water of 4.5 times of material, decoct, keep slight boiling condition 2.2h, filter, filtrate adds the 5% of filtrate quality Sal, 70
Stir 65min at DEG C, obtain Chinese medical concrete, it is 6% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, at 85 DEG C
Water bath with thermostatic control environment under, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 7min, is cooled to after room temperature and adds vitamin
E, L-Glutamine, mix, and dry, pulverize 80 mesh sieves, add acidulant, adjust PH.
The agent of this anti-heat stress, takes in the morning and evening, and each takes, and anti-heat stress agent and chicken feed is pressed 0.1: 1 matter
Amount is than mixing.
Embodiment 4
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 20g, Flos Lonicerae 15g, the Rhizoma Anemarrhenae
10g, Radix Glycyrrhizae 20g, Vitamin E 0.1g, L-Glutamine 20g.
Chicken also includes acidulant with anti-heat stress agent, is to be mixed by 1: 1.1: 3 mass ratio by citric acid, calcium propionate and Fructus Crataegi
Close, addition is the pH value adjusting anti-heat stress agent to 6.
Chicken anti-heat stress agent, its preparation method comprises the following steps：It is mixed after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively
Close, obtain Chinese medicine compound, add the ethanol that concentration is 15%, soak Chinese medicine compound 10min, pull out and drain, add Chinese medicine to mix
Close the water of 5 times of material, decoct, keep slight boiling condition 2.5h, filter, filtrate adds the 7% of filtrate quality Sal, at 60 DEG C
Lower stirring 70min, obtains Chinese medical concrete, and it is 5% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, at 80 DEG C
Under water bath with thermostatic control environment, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 8min, be cooled to after room temperature add Vitamin E,
L-Glutamine, mixes, and dry, pulverize 80 mesh sieves, adds acidulant, adjusts PH.
The agent of this anti-heat stress, takes in the morning and evening, and each takes, and anti-heat stress agent and chicken feed is pressed 0.08: 1 matter
Amount is than mixing.
Embodiment 5
The anti-heat stress agent of one breeder, comprises following raw material by weight：Gypsum Fibrosum 15g, Flos Lonicerae 20g, the Rhizoma Anemarrhenae
13g, Radix Glycyrrhizae 15g, Vitamin E 0.5g, L-Glutamine 5g.
Chicken also includes acidulant with anti-heat stress agent, is to be mixed by 1: 1.1: 3 mass ratio by citric acid, calcium propionate and Fructus Crataegi
Close, addition is the pH value adjusting anti-heat stress agent to 5.5.
Chicken anti-heat stress agent, its preparation method comprises the following steps：It is mixed after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively
Close, obtain Chinese medicine compound, add the ethanol that concentration is 15%, soak Chinese medicine compound 10min, pull out and drain, add Chinese medicine to mix
Close the water of 4 times of material, decoct, keep slight boiling condition 2h, filter, filtrate adds the 4% of filtrate quality Sal, at 60 DEG C
Stirring 70min, obtains Chinese medical concrete, and it is 7% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, in 90 DEG C of perseverance
Under tepidarium environment, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 8min, adds Vitamin E, paddy after being cooled to room temperature
Glutamine, mixes, and dry, pulverize 80 mesh sieves, adds acidulant, adjusts PH.
The agent of this anti-heat stress, takes in the morning and evening, and each takes, and anti-heat stress agent and chicken feed is pressed 0.08: 1 matter
Amount is than mixing.
Claims (5)
1. a breeder anti-heat stress agent is it is characterised in that comprise following raw material by weight：Gypsum Fibrosum 15～20, gold
Flos Lonicerae 15～20, the Rhizoma Anemarrhenae 10～15, Radix Glycyrrhizae 15～20, Vitamin E 0.1～0.5, L-Glutamine 5～20.
2. chicken as claimed in claim 1 with anti-heat stress agent it is characterised in that comprising following raw material by weight：Raw
Gypsum Fibrosum 18, Flos Lonicerae 18, the Rhizoma Anemarrhenae 13, Radix Glycyrrhizae 18, Vitamin E 0.3, L-Glutamine 13.
3. chicken as claimed in claim 1 or 2 with anti-heat stress agent it is characterised in that also including acidulant, be by citric acid,
Calcium propionate and Fructus Crataegi press 1: 0.7～1.1: 3～5 mass ratio mixing, addition be adjust the pH value of anti-heat stress agent to 5.5～
6.
4. the preparation method of anti-heat stress agent of the chicken described in preparation claim 1 or 2 is it is characterised in that comprise the following steps：
Mix after Flos Lonicerae, the Rhizoma Anemarrhenae and Radix Glycyrrhizae are cleaned respectively, obtain Chinese medicine compound, add the ethanol that concentration is 15～20%, soak
Chinese medicine compound 10～15min, pulls out and drains, and adds the water of 4～5 times of Chinese medicine compound, decocts, keep slight boiling condition 2～
2.5h, filters, and adds the 4～7% of filtrate quality Sal, stir 60～70min, obtain Chinese medicine at 60～80 DEG C in filtrate
Extractum, it is 5～7% that filtering residue is dried to water content, pulverized 80 mesh sieves, and obtained Chinese medicine powder, in 80～90 DEG C of water bath with thermostatic control ring
Under border, by Chinese medicine powder, Chinese medical concrete, Gypsum Fibrosum mixing, stir-fry 5～8min, adds Vitamin E, glutamy after being cooled to room temperature
Amine, mixes, and dry, pulverize 80 mesh sieves, adds acidulant, adjusts PH.
5. the chicken as described in Claims 1 to 4, with anti-heat stress agent it is characterised in that the agent of this anti-heat stress, respectively takes one sooner or later
Secondary, each take, anti-heat stress agent is mixed by 0.08～0.12: 1 mass ratio with chicken feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610941025.0A CN106421307A (en) | 2016-10-31 | 2016-10-31 | Heat stress resistant agent used for chicken and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610941025.0A CN106421307A (en) | 2016-10-31 | 2016-10-31 | Heat stress resistant agent used for chicken and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421307A true CN106421307A (en) | 2017-02-22 |
Family
ID=58178262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610941025.0A Pending CN106421307A (en) | 2016-10-31 | 2016-10-31 | Heat stress resistant agent used for chicken and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106421307A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387367A (en) * | 2020-05-18 | 2020-07-10 | 南阳中农高盛生物工程有限公司 | Additive for preventing stress egg drop of laying ducks and preparation method and application thereof |
| CN115969927A (en) * | 2022-11-29 | 2023-04-18 | 华中农业大学 | Traditional Chinese medicine compound with effect of resisting heat stress of livestock and poultry and preparation method thereof |
| CN116870091A (en) * | 2023-07-13 | 2023-10-13 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101313731A (en) * | 2008-07-17 | 2008-12-03 | 北京中农博乐科技开发有限公司 | Anti-stress feedstuff additive |
| CN105878397A (en) * | 2014-11-24 | 2016-08-24 | 李雷 | Composition capable of regulating transportation stress of cattle and sheep |
-
2016
- 2016-10-31 CN CN201610941025.0A patent/CN106421307A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101313731A (en) * | 2008-07-17 | 2008-12-03 | 北京中农博乐科技开发有限公司 | Anti-stress feedstuff additive |
| CN105878397A (en) * | 2014-11-24 | 2016-08-24 | 李雷 | Composition capable of regulating transportation stress of cattle and sheep |
Non-Patent Citations (3)
| Title |
|---|
| 梁剑平: "《中兽药学》", 31 January 2014, 军事医学科学出版社 * |
| 王继华: "《肥育猪饲料配方设计技术》", 28 February 2013, 科学技术文献出版社 * |
| 赵书广: "《中国养猪大成 2版》", 31 May 2013, 中国农业出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387367A (en) * | 2020-05-18 | 2020-07-10 | 南阳中农高盛生物工程有限公司 | Additive for preventing stress egg drop of laying ducks and preparation method and application thereof |
| CN115969927A (en) * | 2022-11-29 | 2023-04-18 | 华中农业大学 | Traditional Chinese medicine compound with effect of resisting heat stress of livestock and poultry and preparation method thereof |
| CN115969927B (en) * | 2022-11-29 | 2023-09-26 | 华中农业大学 | Chinese herbal compound with anti-heat stress effect on livestock and poultry and preparation method thereof |
| CN116870091A (en) * | 2023-07-13 | 2023-10-13 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
| CN116870091B (en) * | 2023-07-13 | 2024-04-12 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101213952B (en) | Method for producing low cholesterol egg without residual agricultural chemical | |
| CN103156095B (en) | Mixed feed of young broiler chickens and preparation method of feed | |
| CN103652361B (en) | Feed for postpartum sow in lactation period of 1-20 days and preparation method thereof | |
| CN102578397B (en) | Chinese herbal medicine feed additive, Chinese herbal medicine mixed feed and preparation method thereof | |
| CN103749982B (en) | Feed for improving egg yield, traditional Chinese medicine additive and preparation method thereof | |
| CN103141709A (en) | Carp feed and preparation method thereof | |
| CN103478508B (en) | Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed | |
| CN104543380A (en) | Chinese herbal medicine feed additive | |
| CN105746898A (en) | Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof | |
| CN104082540A (en) | Feed for health-care egg | |
| CN104783003A (en) | Chinese herbal medicine complete feed for piglets and preparation method of Chinese herbal medicine complete feed | |
| CN106421307A (en) | Heat stress resistant agent used for chicken and preparation method thereof | |
| CN105535198A (en) | Traditional Chinese medicine composition for treating poultry hydropericardium | |
| CN105639098A (en) | Green feed additive for livestock and preparation method thereof | |
| CN107898955B (en) | Medicine for promoting growth and development of pigs as well as preparation method and application thereof | |
| CN103721103A (en) | Medicine for treating swine erysipelas and preparation method thereof | |
| CN106729332A (en) | A kind of composition for preventing and treating bovine rumen acid poisoning and preparation method thereof | |
| CN104304809B (en) | Milk cow in lactation period feed additive and application thereof | |
| CN104082539B (en) | Health-care eggs additive | |
| CN102600267A (en) | Medicine for treating damp-heat calf diarrhea | |
| CN104970220A (en) | Compound feed for sows in suckling period and preparation method thereof | |
| CN104147586A (en) | Chinese herbal medicine composition and fodder for preventing and treating cold irritable enteritis of quails | |
| CN103947893B (en) | A kind of feed, Chinese medicine composition and preparation method for preventing and treating duck aspergillosis | |
| CN105309825A (en) | Feed additive capable of resisting heat stress and relieving oxidative stress injuries and used for broiler chickens | |
| CN109221786A (en) | A kind of nuisanceless meat chicken feed additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170222 |