CN106421186A - Traditional Chinese medicinal composition for treating chronic gastric ulcer and preparation method of traditional Chinese medicinal composition - Google Patents

Traditional Chinese medicinal composition for treating chronic gastric ulcer and preparation method of traditional Chinese medicinal composition Download PDF

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CN106421186A
CN106421186A CN201610942090.5A CN201610942090A CN106421186A CN 106421186 A CN106421186 A CN 106421186A CN 201610942090 A CN201610942090 A CN 201610942090A CN 106421186 A CN106421186 A CN 106421186A
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extract
parts
gastric ulcer
treating chronic
chinese medicine
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李淑梅
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
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    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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    • A61K36/32Burseraceae (Frankincense family)
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    • A61K36/42Cucurbitaceae (Cucumber family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
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    • A61K36/62Nymphaeaceae (Water-lily family)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a traditional Chinese medicinal composition for treating chronic gastric ulcer. The traditional Chinese medicinal composition is prepared from the following medicinal raw materials in parts by weight: 3-12 parts of rhizoma corydalis, 2-8 parts of caulis sargentodoxae, 3-8 parts of flos chrysanthemi indici, 2-6 parts of flos carthami, 3-8 parts of frankincense, 5-15 parts of a fructus momordicae extract, 4-8 parts of a lentinus edodes extract, 2-8 parts of a mango extract, 3-6 parts of a centella asiatica extract, 2-10 parts of a lotus leaf extract, 2-5 parts of a paeonia albiflora root extract and 2-5 parts of a grape seed extract.

Description

A kind of Chinese medicine composition treating chronic gastric ulcer and preparation method
Technical field
The invention belongs to technical field of Chinese medicines, specifically a kind of Chinese medicine composition treating chronic gastric ulcer and preparation side Method.
Background technology
Peptic Ulcerss or peptic ulcer are a kind of common digestive tract disease, can betide esophaguses, stomach or duodenum, Stomach-intestinal anastomosis mouth can be betided nearby or in the Meckel diverticulum containing gastric mucosa, because gastric ulcer and duodenal ulcer Most common, therefore typically so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.
Why it is referred to as peptic ulcer, is because previously thinking that gastric ulcer and duodenal ulcer are due to gastric acid With pepsin mucosa autodigestion formed, in fact gastric acid and pepsin be ulcer main cause it One, also other reasonses can form peptic ulcer.
Because the cause of disease of gastric ulcer and duodenal ulcer and clinical symptoms have many similarities, be sometimes difficult to differentiate between be Gastric ulcer or duodenal ulcer, are therefore often diagnosed as peptic ulcer, or taste-blindness rate, if can be clearly In stomach or duodenum, that can directly be diagnosed as gastric ulcer or duodenal ulcer to ulcer.
Content of the invention
The purpose of the present invention, is to overcome the deficiency of existing above-mentioned technology, provides a kind of Chinese medicine treating chronic gastric ulcer Compositionss and preparation method, this Chinese medicine takes effect rapidly, and cure rate is high.
For solving the above problems, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition treating chronic gastric ulcer, is made up of the crude drug of following parts by weight:Rhizoma Corydalis 3-12 part, red Rattan 2-8 part, Flos Chrysanthemi Indici 3-8 part, Flos Carthami 2-6 part, Olibanum 3-8 part, Fructus Momordicae extract 5-15 part, Lentinus Edodes extract 4-8 part, awns Berry extract 2-8 part, Herba Centellae extract 3-6 part, Folium Nelumbinis extract 2-10 part, Radix Paeoniae Alba extract 2-5 part, Semen Vitis viniferae extract 2-5 part.
The following is the improvement further to technique scheme:
Fructus Momordicae extract, the content of Momordica-Glycosides is containing 80%;In Lentinus Edodes extract, the content of lentinan is 20-30%; In mango extract, the content of chimonin is 45-65%.
In described Herba Centellae extract, the content of asiatic acid is 30-40%;In described Folium Nelumbinis extract, lotus flavone Content is 5-10%;In Radix Paeoniae Alba extract, the content of peoniflorin is 15%-20%.
In Semen Vitis viniferae extract, anthocyanidin content is 95%.
The following is the improvement further to technique scheme:
A kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer, comprises the following steps:
1)Take the Rhizoma Corydalis of above-mentioned weight portion, Caulis Sargentodoxae, Flos Chrysanthemi Indici, Flos Carthami, mix, put in decocting device, first The secondary water adding 10 times of weight portions, soaks 3 hours, decocts boiling 20 minutes with high heat, then with slow fire boiling 15 minutes, obtains final product the Decoction liquor, first time decoction liquor is poured in container;Obtain medicinal liquid A;
2)Fructus Momordicae extract, Lentinus Edodes extract, mango extract are stirred the vinegar water adding 1000 parts;Then static 30 Minute takes supernatant;Obtain medical liquid B;
3)Herba Centellae extract, Folium Nelumbinis extract, Radix Paeoniae Alba extract are stirred, adds 1000 parts of aqueous alkali;Then static Take supernatant within 30 minutes;Obtain medicinal liquid C;
4)By Semen Vitis viniferae extract, stir, add 1000 parts of saline solutions;Then take supernatant within static 30 minutes;Obtain medicinal liquid D;
5), by medicinal liquid A, medical liquid B, medicinal liquid C and medicinal liquid D mix, then be again heated to seethe with excitement, you can medicine of the present invention.
The following is the improvement further to technique scheme:
Described aqueous alkali is the aqueous solution of sodium bicarbonate, the mass ratio 1 of sodium bicarbonate and water:30.
The following is the improvement further to technique scheme:
Described vinegar water is the aqueous solution of vinegar, and vinegar is 1 with the mass ratio of water:10.
The following is the improvement further to technique scheme:
Described saline solution is the aqueous solution of Sal, and Sal is 1 with the mass ratio of water:15.
Described decocting device includes cylinder, is provided with shaft in described cylinder, and described shaft extends to the bottom of cylinder Portion;The bottom of described rotary electric machine is provided with cone bottom, and the lower section of described cone bottom is provided with copper backing, sets in described copper backing It is equipped with passage, in described cone bottom, be fixedly installed groove.
Described decocting device also includes the groove matching with cone bottom, cone bottom and groove interference fit, described stirring Fin is right angled triangle, and described minor face compares 1 with the length on long side:3;Agitating fins are connected with agitating fins afterbody, described Agitating fins afterbody is rectangular sheet structure, the length-width ratio 2 of described agitating fins:3;Rotary shaft rotate when, copper backing with cone bottom Portion rubs.
, through rational compatibility, the synergism of each Chinese medicine, therapeutic effect is notable for the present invention, compared with application Western medicine, controls More rate is high, and instant effect has no toxic side effect, and is difficult to recur, treatment cost is low.
Invention has good curative effect to treatment chronic gastric ulcer, and has no toxic side effect, and each course for the treatment of is 2 days, takes daily Twice, can cure after taking 1~2 course for the treatment of, cure rate reaches 100%, and effective percentage reaches 100%.
To stomachache remission rate 96%;The patient having fixing enclosed mass to abdominal part has 86% patient's enclosed mass to disappear;The patient of melena 100% disappearance.
Below in conjunction with drawings and Examples, the present invention is further illustrated.
Accompanying drawing 1 is the structural representation of decocting device;
Accompanying drawing 2 is the sectional view of decocting device;
Accompanying drawing 3 is the structural representation of cone bottom.
In figure:
1- lid;2- cylinder;3- mounting groove;4- net cylinder;5- rotary electric machine;6- fixed seat;7- agitating fins;8- mounting knob; 9- agitating fins afterbody;10- shaft;11- cylinder bottom;12- bores bottom;13- copper backing;14- passage;15- groove.
Specific embodiment
Embodiment 1, a kind of Chinese medicine composition treating chronic gastric ulcer, it is made up of the crude drug of following parts by weight:Prolong 3 parts of Rhizoma Corydalis, 2 parts of Caulis Sargentodoxae, 3 parts of Flos Chrysanthemi Indici, 2 parts of Flos Carthami, 3 parts of Olibanum, 5 parts of Fructus Momordicae extract, 4 parts of Lentinus Edodes extract, Fructus Mangifera Indicae 2 parts of extract, 3 parts of Herba Centellae extract, 2 parts of Folium Nelumbinis extract, 2 parts of Radix Paeoniae Alba extract, 2 parts of Semen Vitis viniferae extract.
Embodiment 2, a kind of Chinese medicine composition treating chronic gastric ulcer, it is made up of the crude drug of following parts by weight:Prolong 12 parts of Rhizoma Corydalis, 8 parts of Caulis Sargentodoxae, 8 parts of Flos Chrysanthemi Indici, 6 parts of Flos Carthami, 8 parts of Olibanum, 15 parts of Fructus Momordicae extract, 8 parts of Lentinus Edodes extract, awns 8 parts of berry extract, 6 parts of Herba Centellae extract, 10 parts of Folium Nelumbinis extract, 5 parts of Radix Paeoniae Alba extract, 5 parts of Semen Vitis viniferae extract.
Embodiment 3, a kind of Chinese medicine composition treating chronic gastric ulcer, it is made up of the crude drug of following parts by weight:Prolong 4 parts of Rhizoma Corydalis, 6 parts of Caulis Sargentodoxae, 5 parts of Flos Chrysanthemi Indici, 4 parts of Flos Carthami, 5 parts of Olibanum, 10 parts of Fructus Momordicae extract, 6 parts of Lentinus Edodes extract, Fructus Mangifera Indicae 6 parts of extract, 4 parts of Herba Centellae extract, 8 parts of Folium Nelumbinis extract, 4 parts of Radix Paeoniae Alba extract, 4 parts of Semen Vitis viniferae extract.
A kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer, comprises the following steps:
1)Take the Rhizoma Corydalis of above-mentioned weight portion, Caulis Sargentodoxae, Flos Chrysanthemi Indici, Flos Carthami, mix in the decocting device put into, for the first time Add the water of 10 times of weight portions, soak 3 hours, decoct boiling 20 minutes with high heat, then with boiling by slow fire 15 minutes, obtain final product first Secondary decoction liquor, first time decoction liquor is poured in container;Obtain medicinal liquid A;
2)Fructus Momordicae extract, Lentinus Edodes extract, mango extract are stirred the vinegar water adding 1000 parts;Then static 30 Minute takes supernatant;Obtain medical liquid B;
3)Herba Centellae extract, Folium Nelumbinis extract, Radix Paeoniae Alba extract are stirred, adds 1000 parts of aqueous alkali;Then static Take supernatant within 30 minutes;Obtain medicinal liquid C;
4)By Semen Vitis viniferae extract, stir, add 1000 parts of saline solutions;Then take supernatant within static 30 minutes;Obtain medicinal liquid D;
5), by medicinal liquid A, medical liquid B, medicinal liquid C and medicinal liquid D mix, then be again heated to seethe with excitement, you can medicine of the present invention.
Described aqueous alkali is the aqueous solution of sodium bicarbonate, the mass ratio 1 of sodium bicarbonate and water:30.
Described vinegar water is the aqueous solution of vinegar, and vinegar is 1 with the mass ratio of water:10.
Described saline solution is the aqueous solution of Sal, and Sal is 1 with the mass ratio of water:15.
, through rational compatibility, the synergism of each Chinese medicine, therapeutic effect is notable for the present invention, compared with application Western medicine, controls More rate is high, and instant effect has no toxic side effect, and is difficult to recur, treatment cost is low.
Described aqueous alkali is the aqueous solution of sodium bicarbonate, the mass ratio 1 of sodium bicarbonate and water:30.
Described vinegar water is the aqueous solution of vinegar, and vinegar is 1 with the mass ratio of water:10.
Described saline solution is the aqueous solution of Sal, and Sal is 1 with the mass ratio of water:15.
Described decocting device includes cylinder 2, and the top of described cylinder 2 is fixedly installed lid 1, the shell in described cylinder 2 Mounting groove 3 is fixedly installed on wall, is plugged with mounting knob 8 in described mounting groove 3, described mounting knob 8 is fixedly installed Netcom 4;It is provided with several filtering holes in described Netcom 4.
Rotary electric machine 5 and fixed seat 6 are fixedly installed on described lid 1, the rotary shaft of described rotary electric machine 5 is connected with to be stirred Mix axle 10, described shaft 10 extends to the bottom of cylinder 2;The bottom of described rotary electric machine 5 is provided with cone bottom 12, described cone The lower section of bottom 12 is provided with copper backing 13, is provided with passage 14, is fixedly installed in described cone bottom 12 in described copper backing 13 There is groove 15.
The bottom of cylinder 2 is provided with a bottom 11.
It is provided with described copper backing and bore the groove matching in bottom 12, cone bottom 12 and groove interference fit.
Three groups of agitating fins 7 are provided with described rotary shaft, described agitating fins 7 be three groups, on the rotating shaft to Under set gradually.
Described agitating fins are right angled triangle, and described minor face compares 1 with the length on long side:3.
Agitating fins are connected with agitating fins afterbody 9, and described agitating fins afterbody is rectangular sheet structure, described stirring wing The length-width ratio 2 of piece:3.
When rotary shaft rotates, copper backing 13 is rubbed with cone bottom 12.
Add medicine in net cylinder during use, be subsequently adding liquid, in cylinder 2, be provided with heater, medicine is carried out Heat, in heating process, rotary shaft rotates, copper backing 13 is rubbed with cone bottom 12 and constantly rubs.
For investigating clinical efficacy and the safety of above-described embodiment medicine further, we have selected 124 chronic stomaches and burst The case of infectionss carries out clinical trial to the treatment curative effect of medicine of the present invention.
The patient of 124 gastroptosis is randomly divided into four groups, each group case is at aspects such as sex, age, the courses of disease through statistics Credit is analysed, and has comparability.
Matched group adopts appropriate exercise, rational diet, and oral western medicine is treated;Its excess-three group, takes the present invention and implements Example 1 arrives the medicine that embodiment 3 is obtained, taken three times a day, 1 dose every time, and 2 days is a course for the treatment of, takes 1~2 course for the treatment of.
Criterion of therapeutical effect:Cure:Symptom all disappears, and main Physico-chemical tests index is normally;Effective:Symptomatology disappears Or cardinal symptom disappears, main Physico-chemical tests index is normal;Effectively:Cardinal symptom disappears substantially, and main Physico-chemical tests refer to Mark makes moderate progress;Invalid:Main Physico-chemical tests index with treat before unchanged.Curative effect comparision result after two groups of case treatments is such as Table one.
Table one
Group Number of cases Cure(%) Effective(%) Effectively(%) Invalid(%)
Matched group 28 81 85 86 14
Embodiment 1 30 100 100 100 0
Embodiment 2 35 100 100 100 0
Embodiment 3 31 100 100 100 0
By above-mentioned comparison it can be seen that using treatment by Chinese herbs gastroptosis of the present invention, therapeutic effect is notable, with existing Chinese and Western medicine phases Cure rate is high, instant effect for ratio.
Invention has good curative effect to treatment chronic gastric ulcer, and has no toxic side effect, and each course for the treatment of is 2 days, takes daily Twice, can cure after taking 1~2 course for the treatment of, cure rate reaches 100%, and effective percentage reaches 100%.
Medication two days, detects each symptom of patient, is shown in Table two.
Table two
Stomachache remission rate 96%;Fixing enclosed mass 86% disappears;Melena 100% disappears.

Claims (10)

1. a kind of Chinese medicine composition treating chronic gastric ulcer it is characterised in that:It is made up of the crude drug of following parts by weight:Prolong Rhizoma Corydalis 3-12 part, Caulis Sargentodoxae 2-8 part, Flos Chrysanthemi Indici 3-8 part, Flos Carthami 2-6 part, Olibanum 3-8 part, Fructus Momordicae extract 5-15 part, Lentinus Edodess Extract 4-8 part, mango extract 2-8 part, Herba Centellae extract 3-6 part, Folium Nelumbinis extract 2-10 part, Radix Paeoniae Alba extract 2-5 Part, Semen Vitis viniferae extract 2-5 part.
2. as claimed in claim 1 a kind of Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Fructus Momordicae extracts Thing, the content of Momordica-Glycosides is containing 80%;In Lentinus Edodes extract, the content of lentinan is 20-30%;Awns in mango extract The content of fruit glycosides is 45-65%.
3. as claimed in claim 1 a kind of Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Described Herba Centellae carries Take in thing, the content of asiatic acid is 30-40%;In described Folium Nelumbinis extract, the content of lotus flavone is 5-10%;Radix Paeoniae is extracted In thing, the content of peoniflorin is 15%-20%.
4. as claimed in claim 1 a kind of Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Semen Vitis viniferae extract In, anthocyanidin content is 95%.
5. a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer as claimed in claim 1, comprises the following steps: It is characterized in that:
1)Take the Rhizoma Corydalis of above-mentioned weight portion, Caulis Sargentodoxae, Flos Chrysanthemi Indici, Flos Carthami, be added in decocting device, add 10 times of weights for the first time The water of amount part, soaks 3 hours, decocts boiling 20 minutes with high heat, then with boiling by slow fire 15 minutes, obtain final product first time decoction liquor, First time decoction liquor is poured in container;Obtain medicinal liquid A;
2)Fructus Momordicae extract, Lentinus Edodes extract, mango extract are stirred the vinegar water adding 1000 parts;Then static 30 Minute takes supernatant;Obtain medical liquid B;
3)Herba Centellae extract, Folium Nelumbinis extract, Radix Paeoniae Alba extract are stirred, adds 1000 parts of aqueous alkali;Then static Take supernatant within 30 minutes;Obtain medicinal liquid C;
4)By Semen Vitis viniferae extract, stir, add 1000 parts of saline solutions;Then take supernatant within static 30 minutes;Obtain medicinal liquid D;
5), by medicinal liquid A, medical liquid B, medicinal liquid C and medicinal liquid D mix, then be again heated to seethe with excitement, you can medicine of the present invention.
6. as claimed in claim 5 a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Institute State the aqueous solution that aqueous alkali is sodium bicarbonate, the mass ratio 1 of sodium bicarbonate and water:30.
7. as claimed in claim 5 a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Institute State the aqueous solution that vinegar water is vinegar, vinegar is 1 with the mass ratio of water:10.
8. as claimed in claim 5 a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer it is characterised in that:With Under be the improvement further to technique scheme:Described saline solution is the aqueous solution of Sal, and Sal is 1 with the mass ratio of water: 15.
9. as claimed in claim 5 a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer it is characterised in that:Institute State decocting device and include cylinder(2), described cylinder(2)Inside it is provided with shaft(10), described shaft(10)Extend to cylinder (2)Bottom;Described rotary electric machine(5)Bottom be provided with cone bottom(12), described cone bottom(12)Lower section be provided with copper Pad(13), described copper backing(13)Inside it is provided with passage(14), described cone bottom(12)Inside it is fixedly installed groove(15).
10. as claimed in claim 9 a kind of preparation method of the Chinese medicine composition treating chronic gastric ulcer it is characterised in that: Described decocting device also includes and cone bottom(12)The groove matching, bores bottom(12)With groove interference fit, described stirring Fin is right angled triangle, and described minor face compares 1 with the length on long side:3;Agitating fins are connected with agitating fins afterbody(9), institute Stating agitating fins afterbody is rectangular sheet structure, the length-width ratio 2 of described agitating fins:3;When rotary shaft rotates, copper backing(13) With cone bottom(12)Friction.
CN201610942090.5A 2016-10-26 2016-10-26 Traditional Chinese medicinal composition for treating chronic gastric ulcer and preparation method of traditional Chinese medicinal composition Pending CN106421186A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102552796A (en) * 2012-03-17 2012-07-11 许从玉 Chinese medicinal composition for treating chronic gastric ulcer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102552796A (en) * 2012-03-17 2012-07-11 许从玉 Chinese medicinal composition for treating chronic gastric ulcer

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Application publication date: 20170222