CN102886016A - Traditional Chinese medicine preparation for treating cholecystic polypus - Google Patents
Traditional Chinese medicine preparation for treating cholecystic polypus Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating cholecystic polypus, which is prepared by the following raw material medicines in parts by weight: 2 to 4 parts of fried pericarpium citri reticulatae, 0.5 to 1 parts of ginger juice and alum prepared rhizoma pinelliae, 30 to 50 parts of vinegar steamed dark plum pulp, 2 to 3 parts of vinegar prepared purpurea halitium, 8 to 12 parts of radix clematidis, 4 to 8 parts of fried semen hyoscyami, 2 to 4 parts of vinegar prepared rhizoma curcumae, 2 to 4 parts of radix curcumae, and 0.5 to 1.5 parts of wine prepared rheum officinale. The medicine provided by the invention can be prepared into any orally-taken dosage form by a conventional method of the traditional Chinese medicine preparation; furthermore, the traditional Chinese medicine preparation provided by the invention is reliable in efficacy, the cure rate reaches up to 84%, and the total effective ratio reaches up to 100%, so that the value and feasibility of the invention can be proved; and the traditional Chinese medicine preparation is safe and chip, high in patient satisfaction, and convenient to take, thereby being worthy of clinical popularization and use.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine preparation of the treatment cystic polyp of being made by Chinese herbal medicine.
Background technology
Cystic polyp sample pathological changes is not an independently disease, general reference grows in the general name of gallbladder wall mucomembranous surface and outstanding gallbladder intracavity protrusion lesion, comprise known adenoma of gallbladder, cholesterinosis disease, adenomyomatosis of gallbladder, struvite granulomas etc., pathogenic factor is not clear, may be relevant with chronic cholecystitis.Show as certain tissue of gallbladder wall or Cell Component hyperplasia on the pathology, neither inflammation, also non-tumor, the performance of B ultrasonic echo is identical with polyp, so claim cystic polyp sample pathological changes, practises the title cystic polyp, during because of diameter 〉=10mm the tendency that cancerates is arranged, be listed in one of ten large precancerous lesions.Since sick all without specially chapter discussion to this in China's existing unified editing Chinese and Western Medicine and Surgery teaching material, so the clinician generally lacks this disease correctly is familiar with.At present, excision is unique Therapeutic Method, but spirit and the human body are painful, people's potential for adverse effects, the medical expense of great number etc. be can not be ignored after excising gallbladder.
Summary of the invention
For this reason, the object of the present invention is to provide a kind of Chinese medicine preparation that can effectively treat cystic polyp, this Chinese medicine preparation can stop or delay the generation of polyp, alleviates or eliminates polyp.
For achieving the above object, the technical solution used in the present invention is: the Chinese medicine preparation of this treatment cystic polyp is processed into by the crude drug of following weight portion: 2～4 parts of parch Pericarpium Citri Reticulataes, 0.5～1 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 30～50 parts of steaming with vinegar Fructus Mume processed, 2～3 parts of vinegar Sal Ammoniacus processed, 8～12 parts of Radix Clematidis, 4～8 parts of parch Semen Hyoscyamis, 2～4 parts of Rhizoma Curcumae (processed with vinegar), 2～4 parts of Radix Curcumaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed with wine).
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any routine dosage form for oral administration.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used such as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as: pill, powder, tablet, capsule, oral agents etc.
Among the present invention, Pericarpium Citri Reticulatae, [nature and flavor] are bitter, hot, temperature; [return through] returns lung, spleen channel; [function cures mainly] regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.The Rhizoma Pinelliae, [nature and flavor] suffering, temperature; Poisonous; [return through] returns spleen, stomach, lung meridian; [function cures mainly] drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass; Be used for the abundant expectoration cough with asthma, the phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, the syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus.Fructus Mume, [nature and flavor] acid, puckery, flat; [return through] returns liver, spleen, lung, large intestine channel; [function cures mainly] astringes the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris; Be used for chronic cough of deficiency lung, the chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.Sal Ammoniacus, [nature and flavor] are salty; Bitter; Hot; Temperature; Poisonous; [return through] lung; The stomach warp; [function cures mainly] removing blood stasis with potent drugs removing food stagnancy; The softening the hard mass erosion is rotten; The primary symptom abdominal mass is gathered; Dysphagia and regurgitation; The nose meat that lives; The sore throat corneal nebula; The carbuncle scrofula; The malignant boil wart.Radix Clematidis, [nature and flavor] are hot, salty, temperature; [return through] returns urinary bladder channel; [function cures mainly] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain; Be used for rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, the bone larynx of choking with sobs.Semen Hyoscyami, [nature and flavor] are bitter, hot, temperature; Very toxic; [return through] GUIXIN, stomach, Liver Channel; [function cures mainly] relieving spasm to stop pain, the Dingchuan of calming the nerves; Be used for stomach spasm pain, breath with cough, demented.Rhizoma Curcumae, [nature and flavor] are hot, bitter, temperature; [return through] returns liver, spleen channel; [function cures mainly] circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving; Be used for Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Radix Curcumae, [nature and flavor] are hot, bitter, and are cold; [return through] returns liver, the heart, lung meridian; [function cures mainly] regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.Radix Et Rhizoma Rhei, [nature and flavor] hardship, cold; [return through] returns spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation; Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire.
The traditional Chinese medical science claims that " polyp " is " evil meat ", and the abevacuation that it occurs with feelings will is smooth, eating and drinking without temperance causes suffocating of liver and gall function and bile components and amount, accumulatively wet raise phlegm, phlegm and blood stasis be for suffering from, because of headed by the expectorant because of, treat first-selected drying dampness to eliminate phlegm, regulating the flow of Qi and the middle Jiao; Pericarpium Citri Reticulatae, Rhizoma Pinelliae drying dampness to eliminate phlegm are monarch among the side of the present invention; Radix Curcumae, Fructus Mume, Radix Clematidis depressed liver-energy dispersing and function of gallbladder promoting, assisting the monarch drug dissipating depression and eliminating phlegm is minister; Assistant is with Rhizoma Curcumae, Sal Ammoniacus circulation of qi promoting removing blood stasis, removing food stagnancy softening the hard mass, eliminating stasis and resolving masses; Radix Et Rhizoma Rhei is for making, and logical liver, gallbladder, stomach, the intestinal function transferred promotes polyp discharges that come off, the meaning of reside " the six hollow viscera must keep its unobstructed ".Pharmacological research confirms: Pericarpium Citri Reticulatae, Radix Clematidis promote the hepatocyte secretion of bile in the side, strengthen the smooth muscle of bile vesica motor function, eliminate gallbladder inflammation; Fructus Mume, Sal Ammoniacus are again the excrescent traditional active drugs of the scorching class of ablation polyp, and it is a lot of that tested case modern age; Semen Hyoscyami has and press down to kill adenoma, adenocarcinoma cell effect, in having been classified as by the traditional Chinese medical science, advanced esophageal cancer, gastric cancer choice drug.Perfect square of the present invention is take traditional Chinese medical science system theory as guidance, dialectical with debate disease and combine, learn something in history and do not obstinately follow tradition, can transfer smooth gallbladder motion and bile excretion function, eliminate gallbladder inflammation and become the breath factor with the interior environment of gallbladder, again to cell, there are inhibition and eliminating stagnation ablation effect in hyperproliferative, makes the atrophy of polypoid pathological changes, downright bad, come off, recover the gallbladder physiological function, clinical observation shows: curative effect of medicine of the present invention is reliable, cure rate is more than 84%, and total effective rate 100% suffices to show that the party's value and feasibility, safety is inexpensive, taking convenience, patient satisfaction is high, and clinic is carried out using.
The specific embodiment
The Chinese medicine preparation for the treatment of cystic polyp of the present invention is processed into by the crude drug of following weight portion: 2～4 parts of parch Pericarpium Citri Reticulataes, 0.5～1 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 30～50 parts of steaming with vinegar Fructus Mume processed, 2～3 parts of vinegar Sal Ammoniacus processed, 8～12 parts of Radix Clematidis, 4～8 parts of parch Semen Hyoscyamis, 2～4 parts of Rhizoma Curcumae (processed with vinegar), 2～4 parts of Radix Curcumaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed with wine).
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any routine dosage form for oral administration.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used such as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as: pill, powder, tablet, capsule, oral agents etc.
Embodiment 1: the Chinese medicine preparation for the treatment of cystic polyp of the present invention is processed into by the crude drug of following weight portion: 2 parts of parch Pericarpium Citri Reticulataes, 0.5 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 30 parts of steaming with vinegar Fructus Mume processed, 2 parts of vinegar Sal Ammoniacus processed, 8 parts of Radix Clematidis, 4 parts of parch Semen Hyoscyamis, 2 parts of Rhizoma Curcumae (processed with vinegar), 2 parts of Radix Curcumaes, 0.5 part of Radix et Rhizoma Rhei (processed with wine).
Embodiment 2: the Chinese medicine preparation for the treatment of cystic polyp of the present invention is processed into by the crude drug of following weight portion: 3 parts of parch Pericarpium Citri Reticulataes, 0.7 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 40 parts of steaming with vinegar Fructus Mume processed, 2.5 parts of vinegar Sal Ammoniacus processed, 10 parts of Radix Clematidis, 6 parts of parch Semen Hyoscyamis, 3 parts of Rhizoma Curcumae (processed with vinegar), 3 parts of Radix Curcumaes, 1 part of Radix et Rhizoma Rhei (processed with wine).
Embodiment 3: the Chinese medicine preparation for the treatment of cystic polyp of the present invention is processed into by the crude drug of following weight portion: 4 parts of parch Pericarpium Citri Reticulataes, 1 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 50 parts of steaming with vinegar Fructus Mume processed, 3 parts of vinegar Sal Ammoniacus processed, 12 parts of Radix Clematidis, 8 parts of parch Semen Hyoscyamis, 4 parts of Rhizoma Curcumae (processed with vinegar), 4 parts of Radix Curcumaes, 1.5 parts of Radix et Rhizoma Rhei (processed with wine).
Clinical observation material
Between 2008-2010, the inventor adopts mechanical sampling to be divided at random two groups to outpatient service cystic polyp sample pathological changes patient, every group of 30 people, and the Chinese medicinal capsule preparation that treatment group is used development carries out observation of curative effect, and is existing that report the test is as follows:
Data and method:
1, ordinary circumstance: diagnosis is with reference to " ultrasonic diagnosis ".Man's 32 examples, women 28 examples, minimum 27 years old of age, maximum 57 years old, 44 years old mean age.The course of disease is the shortest 6 days, and is the longest 12 years.Polypoid disease straightens footpath 4-6mm person, 56 examples, 〉=7mm person 4 examples, single polypoid pathological changes 38 examples, 2 above person's 22 examples.Wherein merge cholecystitis, cholelithiasis person 22 examples, chronic hepatitis 8 examples, bile reflux gastritis 7 examples.Two groups of basic conditions are balanced, have comparability.
2, method: meet single blind method principle.Matched group: berberine hydrochloride sheet 0.2tid, Anetholtnithoines 25mg tid, Metoclopramide Tablets 5-10mg tid, 1 month is a course for the treatment of; Treatment group: medicine of the present invention, identify that through herbal species pure processing, the process of preparing Chinese medicine, drying, grinding fine powder are crossed sieve No. 6, dress " 0 " number hard capsules, every is heavy by 0.5, and each 4, every day 3 times, after the meal warm boiled water.1 month is a course for the treatment of.The check B ultrasonic is judged curative effect after finishing for one course for the treatment of, and the person of not healing enters next course for the treatment of, can be used in conjunction three courses for the treatment of.
3, efficacy determination: subjective symptoms disappears, and B ultrasonic check polypoid disease becomes the sound disappearance again and is recovery from illness; Subjective symptoms disappears, and pathological changes echo attenuates or dwindle 〉=1/4 be produce effects; Pathological changes echo is invalid without significant change.
The result:
3 courses for the treatment of finish, treatment group 28 examples of fully recovering, produce effects 2 examples, cure rate 84%; Matched group 4 examples of fully recovering, cure rate be 12%, two group of curative effect relatively, the treatment group cure rate is 7 times of matched groups, the difference highly significant.See Table:
Two groups of Clinical efficacy comparisons
| Group | The example number | Recovery from illness | Produce effects | Invalid | Total effective rate (%) |
| Treatment group | 30 | 28 | 2 | ? | 100 |
| Matched group | 30 | 4 | ? | 26 | 12 |
Annotate: two groups of cure rates compare: X
2=46.00, P＜0.01, difference has statistical significance
Two groups of cases are not all observed the heart, liver, kidney, blood, gastrointestinal toxicity and untoward reaction, and patient dependence and toleration are good, occur without bad event.
Claims (1)
1. Chinese medicine preparation for the treatment of cystic polyp, the Chinese medicine preparation that it is characterized in that described treatment cystic polyp is to be processed into by the crude drug of following weight portion: 2～4 parts of parch Pericarpium Citri Reticulataes, 0.5～1 part of Sucus Zingberis, the process with Alumen Rhizoma Pinelliae, 30～50 parts of steaming with vinegar Fructus Mume processed, 2～3 parts of vinegar Sal Ammoniacus processed, 8～12 parts of Radix Clematidis, 4～8 parts of parch Semen Hyoscyamis, 2～4 parts of Rhizoma Curcumae (processed with vinegar), 2～4 parts of Radix Curcumaes, 0.5～1.5 part of Radix et Rhizoma Rhei (processed with wine).
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| CN201110203689.4A CN102886016B (en) | 2011-07-20 | 2011-07-20 | Traditional Chinese medicine preparation for treating cholecystic polypus |
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| CN201110203689.4A CN102886016B (en) | 2011-07-20 | 2011-07-20 | Traditional Chinese medicine preparation for treating cholecystic polypus |
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| CN102886016B CN102886016B (en) | 2014-07-02 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550581A (en) * | 2013-11-01 | 2014-02-05 | 陈小莉 | Traditional Chinese medicine composition for treating gallbladder polyps |
| CN103656499A (en) * | 2013-12-03 | 2014-03-26 | 王纯治 | Traditional Chinese medicinal mixture for treating gallbladder polyps, and preparation method thereof |
| CN106511895A (en) * | 2016-11-28 | 2017-03-22 | 北京中山医院有限公司 | Traditional Chinese medicine decoction for treating polyp of gallbladder |
Citations (3)
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| CN101972447A (en) * | 2010-09-29 | 2011-02-16 | 韩世昌 | Traditional Chinese medicine oral liquid for treating cholecystitis and gallstones and preparation method thereof |
| CN102008691A (en) * | 2010-11-11 | 2011-04-13 | 吴金霞 | Traditional Chinese medicine preparation for treating acute cholecystitis |
| CN102018917A (en) * | 2009-09-17 | 2011-04-20 | 陈恒树 | Traditional Chinese medicine pill for treating various polypi |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018917A (en) * | 2009-09-17 | 2011-04-20 | 陈恒树 | Traditional Chinese medicine pill for treating various polypi |
| CN101972447A (en) * | 2010-09-29 | 2011-02-16 | 韩世昌 | Traditional Chinese medicine oral liquid for treating cholecystitis and gallstones and preparation method thereof |
| CN102008691A (en) * | 2010-11-11 | 2011-04-13 | 吴金霞 | Traditional Chinese medicine preparation for treating acute cholecystitis |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550581A (en) * | 2013-11-01 | 2014-02-05 | 陈小莉 | Traditional Chinese medicine composition for treating gallbladder polyps |
| CN103550581B (en) * | 2013-11-01 | 2015-08-26 | 陈小莉 | A kind of Chinese medicine composition for the treatment of cystic polyp |
| CN103656499A (en) * | 2013-12-03 | 2014-03-26 | 王纯治 | Traditional Chinese medicinal mixture for treating gallbladder polyps, and preparation method thereof |
| CN103656499B (en) * | 2013-12-03 | 2016-12-07 | 王纯治 | A kind of Traditional Chinese drug mixture treating cystic polyp and preparation method thereof |
| CN106511895A (en) * | 2016-11-28 | 2017-03-22 | 北京中山医院有限公司 | Traditional Chinese medicine decoction for treating polyp of gallbladder |
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| CN102886016B (en) | 2014-07-02 |
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Inventor after: Ma Quanyi Inventor after: Ma Xi Inventor after: Xu Peng Inventor after: Xu Xiao Inventor after: Wang Wei Inventor after: Lu Nannan Inventor before: Ma Quanyi Inventor before: Lu Nannan Inventor before: Xu Xiao Inventor before: Wang Wei Inventor before: Xu Peng |
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