CN106421073A - Drug for treating chilblains and preparation method of drug - Google Patents
Drug for treating chilblains and preparation method of drug Download PDFInfo
- Publication number
- CN106421073A CN106421073A CN201611172669.4A CN201611172669A CN106421073A CN 106421073 A CN106421073 A CN 106421073A CN 201611172669 A CN201611172669 A CN 201611172669A CN 106421073 A CN106421073 A CN 106421073A
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- CN
- China
- Prior art keywords
- camphora
- grams
- gram
- aconiti kusnezoffii
- radix aconiti
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention discloses a drug for treating chilblains and a preparation method of the drug. The drug is mainly made from Chinese angelica, camphor, safflowers, radix aconiti kusnezoffii, cassia twigs and Chinese prickly ash according to a certain weight ratio. The drug has functions of promoting blood circulation, stimulating meridians, removing stasis, relieving pain and warming spleen and stomach for dispelling cold, has quick action and good curative effect when being used for treating the chilblains, and is free from side effect.
Description
Technical field
The present invention relates to a kind of medicine for treating chilblain, belongs to the field of Chinese medicines.
Background technology
Chilblain is body to be damaged by the caused whole body of low temperature invasion and attack or local, with handss, foot, auricle etc. as common,
Primary disease is that QI-blood circulation is not smooth, and passages through which vital energy circulates is checked due to attacked by the cold and evil, blood stream stasis and caused by.As western medicine freezes
Skin ulcer weak curative effect, therapeutic effect is not obvious.Therefore, there is great demand to the Chinese medicine of effectively treatment chilblain in people.So far
Till, it has not been found that the relevant report with regard to the present invention.
Content of the invention
The present inventor have found the Chinese medicines for the treatment of chilblain finally through development test repeatedly and the checking of clinical trial
Thing, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition for treating chilblain.
Another object of the present invention just there is provided the preparation method of the composition of medicine.
Medicine of the present invention is to select Radix Angelicae Sinensis, Camphora, Flos Carthami, Radix Aconiti Kusnezoffii, Ramulus Cinnamomi, Pericarpium Zanthoxyli, 95% ethanol to be combined preparing
, these drug regimens are caused each efficacy of drugs to produce synergism such that it is able to the recurrence of effectively treatment chilblain.Wherein select
Its nature and flavor sweet, acrid, warm is because with Radix Angelicae Sinensis, enter the heart, liver, spleen channel, there is a benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturize laxation, control
Menoxenia, amenorrhea is suffered from abdominal pain, and abdominal mass knot is poly-, metrorrhagia, headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome, and dryness of the intestine is difficult just, weight, carbuncle skin ulcer after bloody dysentery
Infectionss, incised wound, injury from falling down.Be because that its nature and flavor is hot from Camphora, two warp of enter the heart spleen, have sensible, parasite killing, pain relieving, ward off dirty
Function, controls trusted subordinate's distending pain, tinea pedis, skin infection scabies, toothache, traumatic injury.It is because that its nature and flavor is pungent from Flos Carthami, temperature, enter the heart, liver
Warp, has a promoting blood circulation to restore menstrual flow, the function of blood stasis removing pain relieving, controlling through closing, abdominal mass, difficult labour, stillborn fetuses, disease that postpartum lochia can't go, and blood stasis are had a pain, carbuncle
Swollen, injury from falling down.From Radix Aconiti Kusnezoffii, different name Radix Aconiti Kusnezoffii, its nature and flavor is pungent, heat, and poisonous, enter liver, spleen, lung meridian search wind prevailing over dampness, cold expelling
Pain relieving, opens expectorant, the function of detumescence, controls anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery,
Sore throat, carbuncle, furuncle, scrofula.Its property acrid-sweet flavor is because from Ramulus Cinnamomi, temperature, enter bladder, the heart, lung meridian, have sweating expelling pathogenic factors from muscles and skin, temperature
Function through promoting blood circulation, controls exterior syndrome due to wind-cold, takes on and carries on the back podomere ache, thoracic obstruction phlegm retention, from Pericarpium Zanthoxyli, amenorrhea abdominal mass is because that its nature and flavor is pungent,
Temperature, poisonous, enter spleen, lung, kidney channel, have warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, solution fish raw meat poison, control food stagnation and stop drinking, trusted subordinate's crymodynia,
Vomiting, oh, cough with dyspnea, anemofrigid-damp arthralgia, have loose bowels, dysentery, colic, toothache, ascariasis, enterobiasiss, pudendal pruritus, sore scabies.
Specific embodiment
The consumption of medicine of the present invention is also the present inventor gropes to summarize through substantial amounts of test repeatedly and draws, each component
Consumption all has preferable curative effect in the range of following weight.
15-25 gram of Radix Angelicae Sinensis 8-12 gram of Flos Carthami of 10-20 gram of Camphora
15-25 gram of Radix Aconiti Kusnezoffii 25-35 gram of Pericarpium Zanthoxyli of 15-25 gram of Ramulus Cinnamomi
95% 550-650 gram of ethanol.
Preferable amount is：
20 grams of Radix Angelicae Sinensis, 15 grams of Camphora, 10 grams of Flos Carthami
20 grams of Radix Aconiti Kusnezoffii, 20 grams of Ramulus Cinnamomi, 30 grams of Pericarpium Zanthoxyli
95% 600 grams of ethanol.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening, slightly dry in the air, section is dried；
2nd, Camphora：The 9-12 month cuts down veteran, takes its tree root, trunk, branch, is split into fragment, puts in distillator and distilled, Lignum cinnamomi camphorae
In the Camphora that contains and volatile oil distillate with vapor, obtain final product rough Camphora after cooling, by rough Camphora again through sublimation purifying, i.e.,
Gum Camphor powder is obtained, camphor powder is entered in model and is squeezed, then become transparent camphor tablet, the used time smashes and grinds into powder；
3rd, Flos Carthami：Net impurity is picked, stem and leaf, base of a fruit head is removed, is dried；
4th, Radix Aconiti Kusnezoffii：Net Radix Aconiti Kusnezoffii is taken, with cold water leaching drift, is changed water 2-3 time daily, only taste taking-up when slightly staying spicy sense to mouth, with sweet
Grass, Semen sojae atricolor add water altogether and boil, and with well-done, the interior no Bai Xinwei degree of Radix Aconiti Kusnezoffii, then remove Radix Glycyrrhizae and Semen sojae atricolor, shine to sixty percent dry, after moistening
Section, dries, per 100 jin of Radix Aconiti Kusnezoffii, with 5 jin of Radix Glycyrrhizae, 10 jin of Semen sojae atricolor；
5th, Ramulus Cinnamomi：Slightly soaked with water, pull out, moistening is dried, weeds out bits to saturating, section；
6th, Pericarpium Zanthoxyli：Remove fruit stem and seed（Semen zanthoxyli）, put in pot fry to making sound, oil goes out, take out, cool.
2nd, prepare
1st, the Radix Angelicae Sinensis for cooking, Camphora, Flos Carthami, Radix Aconiti Kusnezoffii, Ramulus Cinnamomi, Pericarpium Zanthoxyli are soaked in 95% ethanol；
2nd, after soaking 7, filter and remove residue obtains final product Chilblains medicine liquid.
Medicine of the present invention has a promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, the function of warming spleen and stomach for dispelling cold, for treating chilblain instant effect, treats
Imitate, have no side effect.
The beneficial effect of medicine of the present invention is expanded on further below by test example.
1st, physical data
Accept 18 people of chilblain out-patient for medical treatment.
2nd, diagnostic criteria
Winter betides the cold injury of handss, foot, auricle etc., refers to, toe, ear-lobe etc. redness, festers.
3rd, Therapeutic Method
Chilblains medicine liquid external application affected part after net immersion, daily 4-5 time, two weeks is 1 course for the treatment of, to be used in conjunction 2 courses for the treatment of.
4th, therapeutic effect
Through the treatment of 2 courses for the treatment of, 18 patients all fully recover, and effective percentage is 100%.
Claims (3)
1. a kind of medicine for treating chilblain, it is characterised in that：It is made up of the crude drug in following weight range：
15-25 gram of Radix Angelicae Sinensis 8-12 gram of Flos Carthami of 10-20 gram of Camphora
15-25 gram of Radix Aconiti Kusnezoffii 25-35 gram of Pericarpium Zanthoxyli of 15-25 gram of Ramulus Cinnamomi
95% 550-650 gram of ethanol.
2. medicine according to claim 1, the consumption of wherein each crude drug is：
20 grams of Radix Angelicae Sinensis, 15 grams of Camphora, 10 grams of Flos Carthami
20 grams of Radix Aconiti Kusnezoffii, 20 grams of Ramulus Cinnamomi, 30 grams of Pericarpium Zanthoxyli
95% 600 grams of ethanol.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）Radix Angelicae Sinensis：Impurity is picked, is cleaned, moistening, slightly dry in the air, section is dried；
（2）Camphora：The 9-12 month cuts down veteran, takes its tree root, trunk, branch, is split into fragment, puts in distillator and distilled, Camphor tree
The Camphora for containing in wood and volatile oil are distillated with vapor, obtain final product rough Camphora after cooling, by rough Camphora again through sublimation purifying,
Gum Camphor powder is obtained final product, camphor powder is entered in model and is squeezed, then become transparent camphor tablet, the used time smashes and grinds into powder；
（3）Flos Carthami：Net impurity is picked, stem and leaf, base of a fruit head is removed, is dried；
（4）Radix Aconiti Kusnezoffii：Net Radix Aconiti Kusnezoffii is taken, with cold water leaching drift, is changed water 2-3 time daily, only taste taking-up when slightly staying spicy sense to mouth, with sweet
Grass, Semen sojae atricolor add water altogether and boil, and with well-done, the interior no Bai Xinwei degree of Radix Aconiti Kusnezoffii, then remove Radix Glycyrrhizae and Semen sojae atricolor, shine to sixty percent dry, after moistening
Section, dries, per 100 jin of Radix Aconiti Kusnezoffii, with 5 jin of Radix Glycyrrhizae, 10 jin of Semen sojae atricolor；
（5）Ramulus Cinnamomi：Slightly soaked with water, pull out, moistening is dried, weeds out bits to saturating, section；
（6）Pericarpium Zanthoxyli：Remove fruit stem and seed, Semen zanthoxyli, put in pot fry to making sound, oil goes out, take out, cool；
（Two）Prepare
（1）The Radix Angelicae Sinensis for cooking, Camphora, Flos Carthami, Radix Aconiti Kusnezoffii, Ramulus Cinnamomi, Pericarpium Zanthoxyli are soaked in 95% ethanol；
（2）After soaking 7, filter and remove residue is obtained final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611172669.4A CN106421073A (en) | 2016-12-18 | 2016-12-18 | Drug for treating chilblains and preparation method of drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611172669.4A CN106421073A (en) | 2016-12-18 | 2016-12-18 | Drug for treating chilblains and preparation method of drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106421073A true CN106421073A (en) | 2017-02-22 |
Family
ID=58217412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611172669.4A Withdrawn CN106421073A (en) | 2016-12-18 | 2016-12-18 | Drug for treating chilblains and preparation method of drug |
Country Status (1)
| Country | Link |
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| CN (1) | CN106421073A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991541A (en) * | 2019-07-25 | 2020-11-27 | 王晓兵 | Plaster for preventing and treating frostbite and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554417A (en) * | 2003-12-25 | 2004-12-15 | 刘传印 | Frostbite liquid |
| CN102068676A (en) * | 2009-11-19 | 2011-05-25 | 史海霞 | Medicament for treating chilblain |
| CN102266422A (en) * | 2011-07-13 | 2011-12-07 | 黄荣 | Chinese medicinal preparation for treating slight and severe chilblains and production method thereof |
| CN104257944A (en) * | 2014-10-27 | 2015-01-07 | 合肥丰瑞隆生物科技有限公司 | Externally-used traditional Chinese medicine for treating chilblain |
| CN105709021A (en) * | 2016-03-14 | 2016-06-29 | 张春荣 | Muscle and bone recovery unguent and preparation method thereof |
-
2016
- 2016-12-18 CN CN201611172669.4A patent/CN106421073A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554417A (en) * | 2003-12-25 | 2004-12-15 | 刘传印 | Frostbite liquid |
| CN102068676A (en) * | 2009-11-19 | 2011-05-25 | 史海霞 | Medicament for treating chilblain |
| CN102266422A (en) * | 2011-07-13 | 2011-12-07 | 黄荣 | Chinese medicinal preparation for treating slight and severe chilblains and production method thereof |
| CN104257944A (en) * | 2014-10-27 | 2015-01-07 | 合肥丰瑞隆生物科技有限公司 | Externally-used traditional Chinese medicine for treating chilblain |
| CN105709021A (en) * | 2016-03-14 | 2016-06-29 | 张春荣 | Muscle and bone recovery unguent and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111991541A (en) * | 2019-07-25 | 2020-11-27 | 王晓兵 | Plaster for preventing and treating frostbite and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170222 |