CN106420951A - Blood circulation-promoting and wind-damp-dispelling composition as well as preparation method, preparation and application thereof - Google Patents
Blood circulation-promoting and wind-damp-dispelling composition as well as preparation method, preparation and application thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000008280 blood Substances 0.000 title abstract description 10
- 210000004369 blood Anatomy 0.000 title abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 27
- 230000017531 blood circulation Effects 0.000 claims abstract description 25
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 24
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 24
- 241000241413 Propolis Species 0.000 claims abstract description 24
- 230000001737 promoting effect Effects 0.000 claims abstract description 24
- 229940069949 propolis Drugs 0.000 claims abstract description 24
- 241000218176 Corydalis Species 0.000 claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
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- PZEUTLIKVUEDLB-UHFFFAOYSA-N 2-[[[2-[[6-amino-2-[[2-[[6-amino-2-[[2-[[2-[[2-[[2-[[2-[2-[[1-[2-[[2-[[2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[2-[[2-[[2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]acetyl]amino]propanoylamino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]propanoylamino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-(carbamoylamino)propanoyl]-(3-amino-3-oxopropyl)carbamoyl]amino]pentanediamide Chemical compound CCC(C)C(NC(=O)CN)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CO)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(C)CC)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CNC(N)=O)C(=O)N(CCC(N)=O)C(=O)NC(CCC(N)=O)C(N)=O PZEUTLIKVUEDLB-UHFFFAOYSA-N 0.000 abstract 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Medical Informatics (AREA)
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- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a blood circulation-promoting and wind-damp-dispelling composition as well as a preparation method, a preparation and application thereof. The composition comprises the following raw materials in parts by weight: 40-68 parts of gaultheria yunnanensis, 6-15 parts of rhizoma corydalis, 0.1-0.2 part of propolis, 4-6 parts of notoginseng, 0.002-0.004 part of apitoxin, 6-30 parts of honeycomb and 50-100 parts of 75 percent of alcohol. The blood circulation-promoting and wind-damp-dispelling composition disclosed by the invention has the functions of relieving heat, easing pain, dilating blood vessels, dissolving blood lipids, promoting blood circulation, removing blood stasis and improving blood supply, enables nutrients and drugs to effectively reach lesion parts and has a good curative effect on rheumatism as well as joint pain, sciatica, lumbar disc protrusion, hand and foot ache, and hemiplegia caused by the rheumatism.
Description
Technical field
The invention belongs to technical field of Chinese medicines is and in particular to wet compositionss of a kind of promoting blood circulation by removing wind and preparation method thereof, preparation
With application.
Background technology
Rheumatism has the title of " not dead cancer ", is a kind of healthy and obstinate disease of serious harm.Rheumatismal early stage disease
Shape is inconspicuous, is mostly that arthroncuss, stiff, myalgia, weak, xerostomia, eye are done, with the development of the state of an illness, rheumatism also can be drawn
The a series of disease rising, such as arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick ache, seriously also can half body not
Then, cause deformity.Clinical statisticses show, about 45% patient is eventually developed to joint deformity, and 10% is finally completely disabled.In addition wind
Wet also can cause nephropathy, carditises, respiratory tract and disease in the blood system etc..
Be currently used for treating the external skin medicine of rheumatism and oral medicine all compare many, but existing a lot of medicine is all deposited
In problem, the common medicine of such as rheumatic sufferers is the medicine such as nonsteroidal anti-inflammatory agent and adrenocortical hormone, side effect
Greatly, patient is difficult to stand.Some other medicine, then the blood circulation effect that there is enhancing skin is inconspicuous, therefore to rheumatism
The inapparent problem of curative effect, even if effective in cure effective time is also slow, in addition some medicine for rheumatism side effect for oral administration are larger, and for oral administration
, because will being absorbed into blood through digestive tract and passing through focus, the composition that often really can work in affected area is for Chinese medicine
Seldom.Therefore, develop a kind of instant effect, the wet medicine of promoting blood circulation by removing wind of Small side effects is necessary.
Content of the invention
The first object of the present invention is to provide the wet compositionss of promoting blood circulation by removing wind of a kind of instant effect, Small side effects；Second mesh
Be a kind of preparation method of the wet compositionss of promoting blood circulation by removing wind is provided；3rd purpose is to provide a kind of promoting blood circulation by removing wind wet compositionss
Preparation；4th purpose is to provide a kind of application of the wet compositionss of promoting blood circulation by removing wind.
The first object of the present invention is achieved in that described compositionss include the raw material of following weight portion：Caulis et folium gaultheriae yunnanensiss
40 ~ 68 parts, 6 ~ 15 parts of Rhizoma Corydalis, 0.1 ~ 0.2 part of propolis, 4 ~ 6 parts of Radix Notoginseng, 0. 002 ~ 0. 004 parts of Venenum apis, 6 ~ 30 parts of Nidus Vespae,
75% 50 ~ 100 parts of ethanol.
The second object of the present invention is achieved in that and comprises the following steps：
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 18 ~ 22 hours；
（2）Will be through step（1）Raw material after process is weighed and mix homogeneously by formula proportion, then puts mixed raw material
Enter in 75% ethanol and soak 10 ~ 20 days, carry out afterwards being centrifuged, filter, obtain liquid；
（3）Will be through step（2）Add the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration obtains, obtain final product.
The third object of the present invention is achieved in that described preparation is pharmaceutically acceptable for adding in the composition
Adjuvant makes liniment, spray, tincture, liniment, unguentum.
The fourth object of the present invention is achieved in that described compositionss in preventing/treating rheumatism medicine
Application.
Beneficial effects of the present invention：
1st, the wet compositionss of promoting blood circulation by removing wind of the present invention, have antipyretic-antalgic, expansion of blood vessels, dissolving blood fat, blood circulation promoting and blood stasis dispelling, change
The effect of kind blood supply so that nutrient substance and medicine effectively reach lesions position, arthralgia that rheumatism and rheumatism are caused,
The diseases such as sciatica, prolapse of lumbar intervertebral disc, trick are ached, hemiplegia all have good curative effect.
2nd, the present invention is made of with natural Chinese medicinal herb and animal drugs as raw material, and formula is reasonable, lasting medicine, Small side effects,
Instant effect, easy to use.
3rd, rheumatism causes arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick are ached, the morbidity of hemiplegia etc.
Reason is due to angiemphraxises, and various people are distributed, and theory of Chinese medical science is：Obstructed, no pain by smooth breath bitterly, thus Chinese traditional treatment
Mechanism is promoting blood circulation, damp eliminating, dredging the meridian.The compositionss of the present invention are to use for reference experience handed down from one's ancestors, by rheumatismal long-term observation
Research, summarizes through long-term practical exploration and draws, wherein Caulis et folium gaultheriae yunnanensissGaultheria yunnanensis(Franch)
Rehd. there are promoting blood circulation, expansion of blood vessels, wind-damp dispelling effect, Rhizoma CorydalisCorydalis yanhusuoW. T. Wang have antipyretic
Analgesic activity, propolis has promoting blood circulation effect, and Radix Notoginseng has promoting blood circulation, dissolving blood stasis effect, and Venenum apis and Nidus Vespae have wind-damp dispelling effect,
A few taste medicines mix collective effect effect is significant.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but never in any form the present invention is any limitation as,
Based on present invention teach that any conversion of being made or replacement, belong to protection scope of the present invention.
The wet compositionss of promoting blood circulation by removing wind of the present invention, including the raw material of following weight portion：40 ~ 68 parts of Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis
6 ~ 15 parts of rope, 0.1 ~ 0.2 part of propolis, 4 ~ 6 parts of Radix Notoginseng, 0. 002 ~ 0. 004 parts of Venenum apis, 6 ~ 30 parts of Nidus Vespae, 75% ethanol 50 ~ 100
Part.
Described compositionss include the raw material of following weight portion：50 ~ 60 parts of Caulis et folium gaultheriae yunnanensiss, 8 ~ 12 parts of Rhizoma Corydalis, propolis 0.15
Part, 5 parts of Radix Notoginseng, 0. 003 parts of Venenum apis, 10 ~ 20 parts of Nidus Vespae, 75% 87.25 parts of ethanol.
The preparation method of the wet compositionss of promoting blood circulation by removing wind of the present invention, comprises the following steps：
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 18 ~ 22 hours；
（2）Will be through step（1）Raw material after process is weighed and mix homogeneously by formula proportion, then puts mixed raw material
Enter in 75% ethanol and soak 10 ~ 20 days, carry out afterwards being centrifuged, filter, obtain liquid；
（3）Will be through step（2）Add the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration obtains, obtain final product.
Step（1）Described in vacuum lyophilization time be 20 hours.
Step（2）Described in immersion time be 15 days.
Described preparation is to add pharmaceutically acceptable adjuvant to make liniment, spray, tincture, film in the composition
Agent, unguentum.
The using method of described liniment be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
Application in preventing/treating rheumatism medicine for the described compositionss.
Embodiment 1
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 18 hours；
（2）Will be through step（1）Raw material after process weighs 40 parts of Caulis et folium gaultheriae yunnanensiss, 6 parts of Rhizoma Corydalis, 4 parts of Radix Notoginseng, honeybee by formula proportion
6 parts of room, 0.1 part of propolis, mix homogeneously, then by mixed raw material put into 50 part 75% alcohol-pickled 10 days, carry out afterwards from
The heart, filtration, obtain liquid；
（3）Add 0. 002 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described combination
Thing.
Embodiment 2
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 19 hours；
（2）Will be through step（1）Raw material after process weighs 45 parts of Caulis et folium gaultheriae yunnanensiss, 8 parts of Rhizoma Corydalis, 5 parts of Radix Notoginseng, honeybee by formula proportion
10 parts of room, 0.12 part of propolis, mix homogeneously, then by mixed raw material put into 60 part 75% alcohol-pickled 12 days, carry out afterwards
Centrifugation, filtration, obtain liquid；
（3）Add 0. 0025 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described group
Compound.
Embodiment 3
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 20 hours；
（2）Will be through step（1）Raw material after process weighs 50 parts of Caulis et folium gaultheriae yunnanensiss by formula proportion, 10 parts of Rhizoma Corydalis, 5 parts of Radix Notoginseng,
12 parts of Nidus Vespae, 0.14 part of propolis, mix homogeneously, then by mixed raw material put into 70 part 75% alcohol-pickled 14 days, laggard
Row centrifugation, filtration, obtain liquid；
（3）Add 0. 003 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described combination
Thing.
Embodiment 4
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 21 hours；
（2）Will be through step（1）Raw material after process weighs 55 parts of Caulis et folium gaultheriae yunnanensiss by formula proportion, 12 parts of Rhizoma Corydalis, 6 parts of Radix Notoginseng,
15 parts of Nidus Vespae, 0.16 part of propolis, mix homogeneously, then by mixed raw material put into 80 part 75% alcohol-pickled 16 days, laggard
Row centrifugation, filtration, obtain liquid；
（3）Add 0. 0035 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described group
Compound.
Embodiment 5
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 22 hours；
（2）Will be through step（1）Raw material after process weighs 60 parts of Caulis et folium gaultheriae yunnanensiss by formula proportion, 14 parts of Rhizoma Corydalis, 4 parts of Radix Notoginseng,
20 parts of Nidus Vespae, 0.18 part of propolis, mix homogeneously, then by mixed raw material put into 90 part 75% alcohol-pickled 18 days, laggard
Row centrifugation, filtration, obtain liquid；
（3）Add 0. 0038 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described group
Compound.
Embodiment 6
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 22 hours；
（2）Will be through step（1）Raw material after process weighs 68 parts of Caulis et folium gaultheriae yunnanensiss by formula proportion, 15 parts of Rhizoma Corydalis, 6 parts of Radix Notoginseng,
25 parts of Nidus Vespae, 0.2 part of propolis, mix homogeneously, then by mixed raw material put into 100 part 75% alcohol-pickled 20 days, laggard
Row centrifugation, filtration, obtain liquid；
（3）Add 0. 004 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described combination
Thing.
Embodiment 7
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 20 hours；
（2）Will be through step（1）Raw material after process weighs 65 parts of Caulis et folium gaultheriae yunnanensiss by formula proportion, 11 parts of Rhizoma Corydalis, 5 parts of Radix Notoginseng,
27 parts of Nidus Vespae, 0.15 part of propolis, mix homogeneously, then by mixed raw material put into 87.25 part 75% alcohol-pickled 17 days, it
After carry out being centrifuged, filter, obtain liquid；
（3）Add 0. 004 parts of the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration is obtained, obtain final product described combination
Thing.
Embodiment 8
Pharmaceutically acceptable adjuvant is added to make liniment in the compositionss that embodiment 1 is obtained.The user of described liniment
Method be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
Embodiment 9
Pharmaceutically acceptable adjuvant is added to make liniment in the compositionss that embodiment 2 is obtained.The user of described liniment
Method be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
Embodiment 10
Pharmaceutically acceptable adjuvant is added to make liniment in the compositionss that embodiment 5 is obtained.The user of described liniment
Method be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
Embodiment 11
Pharmaceutically acceptable adjuvant is added to make liniment in the compositionss that embodiment 7 is obtained.The user of described liniment
Method be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
Embodiment 12
Pharmaceutically acceptable adjuvant is added to make spray in the compositionss that embodiment 1 is obtained.
Embodiment 13
Pharmaceutically acceptable adjuvant is added to make spray in the compositionss that embodiment 4 is obtained.
Embodiment 14
Pharmaceutically acceptable adjuvant is added to make spray in the compositionss that embodiment 7 is obtained.
Embodiment 15
Pharmaceutically acceptable adjuvant is added to make tincture in the compositionss that embodiment 2 is obtained
Embodiment 16
Pharmaceutically acceptable adjuvant is added to make tincture in the compositionss that embodiment 6 is obtained.
Embodiment 17
Pharmaceutically acceptable adjuvant is added to make liniment in the compositionss that embodiment 1 is obtained.
Embodiment 18
Pharmaceutically acceptable adjuvant is added to make unguentum in the compositionss that embodiment 1 is obtained.
Embodiment 19
Pharmaceutically acceptable adjuvant is added to make unguentum in the compositionss that embodiment 6 is obtained.
Embodiment 20
Select rheumatism includes rheumatism and rheumatism causes arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick acid
Bitterly, hemiplegia, 122 patients such as arthralgia, wherein male 62, women 60, the liniment of gained in embodiment 8 in trouble
Place's painting is put on the skin and is massaged 3～5 minutes with handss, and applies ointment in rubbing, daily 2 ~ 3 times, puts 1 ~ 4ml, medication 30 days every time on the skin, has 121
Example is cured, 1 notable improvement, and is showed no obvious adverse reaction.
Embodiment 21
Select rheumatism includes rheumatism and rheumatism causes arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick acid
Bitterly, hemiplegia, 97 patients such as arthralgia, wherein male 55, women 42, the liniment of gained in embodiment 11 in trouble
Place's painting is put on the skin and is massaged 3～5 minutes with handss, and applies ointment in rubbing, daily 2 ~ 3 times, puts 1 ~ 4ml, medication 30 days every time on the skin, has 95
Cure, 2 notable improvements, and be showed no obvious adverse reaction.
Embodiment 22
Select rheumatism includes rheumatism and rheumatism causes arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick acid
Bitterly, hemiplegia, 110 patients such as arthralgia, wherein male 50, women 60, the spray of gained in embodiment 12
In affected part spraying, daily 2 ~ 3 times, spray 2 ~ 4ml, medication 30 days every time, have 119 healings, 1 notable improvement, and be showed no bright
Aobvious untoward reaction.
Embodiment 23
Select rheumatism includes rheumatism and rheumatism causes arthralgia, sciatica, prolapse of lumbar intervertebral disc, trick acid
Bitterly, hemiplegia, 90 patients such as arthralgia, wherein male 44, women 46, the unguentum of gained in embodiment 19 in trouble
Place's painting is put on the skin and is massaged 3～5 minutes with handss, daily 2 ~ 3 times, sprays 2 ~ 4ml, medication 30 days every time, has 88 healings, 2 significantly good
Turn, and be showed no obvious adverse reaction.
Claims (8)
1. a kind of wet compositionss of promoting blood circulation by removing wind are it is characterised in that described compositionss include the raw material of following weight portion：Caulis et folium gaultheriae yunnanensiss
40 ~ 68 parts, 6 ~ 15 parts of Rhizoma Corydalis, 0.1 ~ 0.2 part of propolis, 4 ~ 6 parts of Radix Notoginseng, 0. 002 ~ 0. 004 parts of Venenum apis, 6 ~ 30 parts of Nidus Vespae,
75% 50 ~ 100 parts of ethanol.
2. the wet compositionss of promoting blood circulation by removing wind according to claim 1 are it is characterised in that described compositionss include following weight
The raw material of part：50 ~ 60 parts of Caulis et folium gaultheriae yunnanensiss, 8 ~ 12 parts of Rhizoma Corydalis, 0.15 part of propolis, 5 parts of Radix Notoginseng, 0. 003 parts of Venenum apis, Nidus Vespae 10 ~ 20
Part, 75% 87.25 parts of ethanol.
3. one kind according to the preparation method of the wet compositionss of the arbitrary described promoting blood circulation by removing wind of claim 1 ~ 2 it is characterised in that including
Following steps：
（1）Caulis et folium gaultheriae yunnanensiss, Rhizoma Corydalis, Radix Notoginseng, Nidus Vespae were pulverized 40 mesh sieves respectively, then propolis was done in -50 DEG C of vacuum freezings
100 mesh sieves were pulverized after dry 18 ~ 22 hours；
（2）Will be through step（1）Raw material after process is weighed and mix homogeneously by formula proportion, then puts mixed raw material
Enter in 75% ethanol and soak 10 ~ 20 days, carry out afterwards being centrifuged, filter, obtain liquid；
（3）Will be through step（2）Add the Venenum apis of formula proportion, mix homogeneously in the liquid that centrifugal filtration obtains, obtain final product.
4. the preparation method of the wet compositionss of promoting blood circulation by removing wind according to claim 3 is it is characterised in that step（1）Described in
The time of vacuum lyophilization is 20 hours.
5. the preparation method of the wet compositionss of promoting blood circulation by removing wind according to claim 3 is it is characterised in that step（2）Described in
The time soaked is 15 days.
6. one kind according to the preparation of the wet compositionss of the arbitrary described promoting blood circulation by removing wind of claim 1 ~ 2 it is characterised in that described system
Agent is to add pharmaceutically acceptable adjuvant to make liniment, spray, tincture, liniment, unguentum in the composition.
7. the preparation of the wet compositionss of promoting blood circulation by removing wind according to claim 6 is it is characterised in that the user of described liniment
Method be treated in vitro, affected part apply put on the skin and with handss massage 3～5 minutes.
8. one kind according to the application of the wet compositionss of the arbitrary described promoting blood circulation by removing wind of claim 1 ~ 2 it is characterised in that described group
Application in preventing/treating rheumatism medicine for the compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611016431.2A CN106420951A (en) | 2016-11-18 | 2016-11-18 | Blood circulation-promoting and wind-damp-dispelling composition as well as preparation method, preparation and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611016431.2A CN106420951A (en) | 2016-11-18 | 2016-11-18 | Blood circulation-promoting and wind-damp-dispelling composition as well as preparation method, preparation and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106420951A true CN106420951A (en) | 2017-02-22 |
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ID=58220481
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611016431.2A Withdrawn CN106420951A (en) | 2016-11-18 | 2016-11-18 | Blood circulation-promoting and wind-damp-dispelling composition as well as preparation method, preparation and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106420951A (en) |
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2016
- 2016-11-18 CN CN201611016431.2A patent/CN106420951A/en not_active Withdrawn
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Application publication date: 20170222 |