CN106390004A - Composition for treating sexual dysfunction and prostate disease and preparation method thereof - Google Patents

Composition for treating sexual dysfunction and prostate disease and preparation method thereof Download PDF

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Publication number
CN106390004A
CN106390004A CN201611185858.5A CN201611185858A CN106390004A CN 106390004 A CN106390004 A CN 106390004A CN 201611185858 A CN201611185858 A CN 201611185858A CN 106390004 A CN106390004 A CN 106390004A
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parts
fructus
rhizoma
radix
herba
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李立
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Individual
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Abstract

The invention discloses a composition for treating sexual dysfunction and prostate disease and a preparation method thereof. The composition comprises the following components: fructus lycii, fructus corni, rehmannia glutinosa, angelica sinensis, eucommia ulmoides, ligusticum wallichii, codonopsis pilosula, rhizoma polygonati, morinda officinalis, rhizoma curculiginis, fructus rosae laevigatae, fructus psoraleae, herba epimedii, schisandra chinensis, semen cuscutae, cinnamon, gorgon euryale seed, rhizoma cibotii, fructus cnidii, fructus alpiniae oxyphyllae, herba cistanche, liquorice, radix astragali, glossy privet fruit, mulberry, paratenodera sinensis saussure, cardamom, agastache rugosus, dried orange peel, cuttlebone, tremolite, gentian, rhizoma alismatis, herba taxilli, fructus tritici levis, hedgehog hide, cortex moutan, rhizoma anemones altaicae and herba asari. According to the composition, through the compatibility of the traditional Chinese medicines with the functions of nourishing kidney yin and warming and tonifying kidney yang and through reasonable regulation of the proportioning, the composition has the advantages of broad-spectrum effect, no side effect, remarkable treatment effect and short curing cycle when used for treating sexual dysfunction and prostate disease.

Description

A kind of the treatment of sexual dysfunction, compositionss of prostatosis and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine, in particular to a kind of the treatment of sexual dysfunction, prostate disease Compositionss of disease and preparation method thereof.
Background technology
It is known that causing one of inducement of male sexual disorder to be chronic prostatosiss.According to statistics, male prostatitis Gland disease sickness rate constantly raises, and has the trend of rejuvenation.Prostatitis and prostatic hyperplasia are common prostatosis, Treatment currently for the sexual dysfunction being caused by prostatosis there is no specific short.
All kinds of antibiotic and urinary system anti-infective, though there is certain short term effect to prostatitis, relapse rate is high, and Heal compared with refractory after forming chronic prostatitiss.Domestic in the 30-50 age to the Drug therapy application estrogen of prostatic hyperplasia Outer once voguish, still someone's application so far.Estrogen really can respite dysuria, but gastrointestinal side effect reaction Very big, affect appetite, when medication is more, easily cause prostate and surrounding tissue adhesion tension, cause peeling operation difficult.In recent years Carry out the development due to receptor theory, external extensive application α receptor blocking agent such as diphenazoline etc. is long-term to Patients with Prostatic Hyperplasia Application, receives rather satisfied effect, but the impact to blood pressure is very big, therefore has hypertension and cardiopathic patient disabling.In addition, The urine of this medicine and import the price such as leads to costly it is difficult to promote.The QIANLIEKANG of domestic use is effective very slow at present, needs long term usage Can take effect, and once saw take after cause the report of oral mucosal ulceration, its reason is probably the anaphylaxiss caused by pollen.Therefore it is right The medicine of the sexual dysfunction being caused by prostatosis in treatment waits to develop further.
Content of the invention
The existing deficiency of the kidney yin of prostatosis, also has the typing of insufficiency of kidney-YANG.Patient's hyperactivity of fire caused by deficiency of YIN of deficiency of the kidney yin, is not suitable for taking Warming the kidney to invigorate YANG medicine；And the patient of insufficiency of kidney-YANG is cold, be not suitable for taking nourishing kidney yin medicine.Inventor grinds through long-term clinic Study carefully discovery：Negative and positive mutual dependence for existence, mutually conversion in human body, with the moon as base, cloudy bad sun is to change for sun.In the treatment deficiency of YIN, yang deficiency disease When, inventor focuses on YANG invigorating simultaneous tonifying YIN, it has been surprisingly discovered that the formula in the application, it can effectively treatment prostate disease Disease, particularly prostatitis and prostatic hyperplasia, and then effect a radical cure the sexual dysfunction being caused by prostatosis.
For achieving the above object, the present invention provides following technical scheme：
A kind of the treatment of sexual dysfunction, compositionss of prostatosis and preparation method thereof, join including following mass fraction Fang Chengfen：
Fructus Lycii 10-20 part, Fructus Corni 10-15 part, Radix Rehmanniae Preparata 20-30 part, Radix Angelicae Sinensis 15-25 part, Cortex Eucommiae 10-14 part, Rhizoma Chuanxiong 5-10 part, Radix Codonopsis 6-12 part, Rhizoma Polygonati 10-20 part, Radix Morindae Officinaliss 10-15 part, Rhizoma Curculiginises 10-15 part, Fructus Rosae Laevigatae 5-10 part, Fructus Psoraleae 5- 10 parts, Herba Epimedii 15-20 part, Fructus Schisandrae Chinensis 6-9 part, Semen Cuscutae 5-12 part, Cortex Cinnamomi 2-5 part, Semen Euryaless 23-26 part, Rhizoma Cibotii 10-16 Part, Fructus Cnidii 5-8 part, Fructus Alpiniae Oxyphyllae 12-16 part, Herba Cistanches 10-16 part, Radix Glycyrrhizae 8-12 part, Radix Astragali 10-16 part, Fructus Ligustri Lucidi 10-16 Part, Fructus Mori 12-16 part, Mulberry Piao sheath 4-12 part, Fructus Amomi Rotunduss 5-10 part, Herba Pogostemoniss 3-6 part, Pericarpium Citri Reticulatae 5-10 part, sea Piao sheath 3-7 part, sun rise Stone 3-6 part, Radix Gentianae 3-5 part, Rhizoma Alismatis 3-6 part, Herba Taxilli 7-11 part, Fructus Tritici Levis 3-8 part, Corium Erinacei Seu Hemiechianuss 2-7 part, Du Cortex Moutan 8-12 Part, Rhizoma Anemones Altaicae 5-9 part and Herba Asari 1-4 part.
Fructus Lycii, Fructus Corni, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Rosae Laevigatae, Fructus Psoraleae, Semen Euryaless, Rhizoma Alismatis, Fructus Tritici Levis, thorn Hedgehog skin, Du's Cortex Moutan, Herba Asari are respectively provided with nourishing the liver and kidney, remove deficiency-heat, hidroschesis, the function of promoting blood circulation to remove blood stasis, blood-activating analgetic and defying age, will Above drug matching has the effect of nourishing kidney yin, nourshing blood and promoting blood circulation；Rhizoma Chuanxiong, Radix Morindae Officinaliss, Herba Epimedii, Rhizoma Cibotii, Fructus Cnidii, Herba Taxilli Life, Rhizoma Curculiginises, Fructus Schisandrae Chinensis, Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, Herba Cistanches, Radix Glycyrrhizae, Mulberry Piao sheath, Actinolitum, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Codonopsis are respectively provided with the kidney warming Tonifying YANG, bone and muscle strengthening, wind-damp dispelling, the function of invigorating the spleen and replenishing QI, above drug matching is had the effect of warming and recuperating the kidney-YANG, invigorating the spleen and replenishing QI； The Radix Astragali has functions that to treat chronic ulcer, the long disunion of the open sore part；Fructus Ligustri Lucidi, Fructus Mori and Radix Gentianae have the work(of improving eyesight black hair Effect；Fructus Amomi Rotunduss, Herba Pogostemoniss, sea Piao sheath and Rhizoma Anemones Altaicae have functions that stomach reinforcing gas, enter diet.
Further, including following mass fraction formula components：
15 parts of Fructus Lycii, 12 parts of Fructus Corni, 25 parts of Radix Rehmanniae Preparata, 18 parts of Radix Angelicae Sinensis, 12 parts of the Cortex Eucommiae, 7 parts of Rhizoma Chuanxiong, 9 parts of Radix Codonopsis, Rhizoma Polygonati 15 parts, 13 parts of Radix Morindae Officinaliss, 12 parts of Rhizoma Curculiginises, 7 parts of Fructus Rosae Laevigatae, 8 parts of Fructus Psoraleae, 18 parts of Herba Epimedii, 7.5 parts of Fructus Schisandrae Chinensis, Semen Cuscutae 8 Part, 4 parts of Cortex Cinnamomi, 25 parts of Semen Euryaless, 13 parts of Rhizoma Cibotii, 7 parts of Fructus Cnidii, 14 parts of Fructus Alpiniae Oxyphyllae, 13 parts of Herba Cistanches, 10 parts of Radix Glycyrrhizae, the Radix Astragali 14 Part, 15 parts of Fructus Ligustri Lucidi, 14 parts of Fructus Mori, 8 parts of Mulberry Piao sheath, 8.5 parts of Fructus Amomi Rotunduss, 5 parts of Herba Pogostemoniss, 7 parts of Pericarpium Citri Reticulatae, 5 parts of sea Piao sheath, Actinolitum 4.5 parts, 4 parts of Radix Gentianae, 4.5 parts of Rhizoma Alismatis, 9 parts of Herba Taxilli, 5.5 parts of Fructus Tritici Levis, 4.5 parts of Corium Erinacei Seu Hemiechianuss, Du 10 parts of Cortex Moutan, Psychotria rubra (Lour.) Poir. Chang 7 parts of Pu and 3 parts of Herba Asari.
The present invention also provides a kind of preparation method of the compositionss of the treatment of sexual dysfunction, prostatosis, including following Step：
(1) according to mass fraction, Fructus Lycii, Fructus Corni, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Rosae Laevigatae, benefit are weighed respectively Bone fat, Semen Euryaless, Rhizoma Alismatis, Fructus Tritici Levis, Corium Erinacei Seu Hemiechianuss, Du's Cortex Moutan, Herba Asari, each formula mix homogeneously adds ethanol, is heated to reflux, Extract, obtain dry cream；
(2) step (1) is got dry extract and pulverized, crossed 100-200 mesh sieve, extracting screen underflow, obtain extracting compositionss；
(3) according to formula components, weigh respectively Rhizoma Chuanxiong, Radix Morindae Officinaliss, Herba Epimedii, Rhizoma Cibotii, Fructus Cnidii, Herba Taxilli, Rhizoma Curculiginises, five Taste, Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, Herba Cistanches, Radix Glycyrrhizae, Mulberry Piao sheath, Actinolitum, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, mix homogeneously, add water Soak 4-7h, boil 3-5h by slow fire, filter, obtain decocting compositionss；
(4) according to formula components, Fructus Ligustri Lucidi, Fructus Mori, Radix Gentianae, Fructus Amomi Rotunduss, Herba Pogostemoniss, sea Piao sheath and Psychotria rubra (Lour.) Poir. Chang are weighed respectively Pu, pulverizes, and crosses 100-200 mesh sieve, extracting screen underflow, obtains powder composition；
(5) compositionss will be extracted, powder composition adds in decoction compositionss, and obtain mixture, mix 20-40min, then Add adjuvant one, make conventional tablet, pill or capsule, you can.
Further, in described step (1), described concentration of alcohol is 85～95%, and the mass fraction adding ethanol is Chinese medicine 5.5-7 times of formula gross mass number, in described step (3), the mass fraction adding water is Chinese medicine formula gross mass number 1.5-4.5 again.
Further, under conditions of vacuum is for 0.06-0.07Mpa, being evaporated to relative density is 1.02-1.08 When, obtain dry cream.
Further, described adjuvant one be yellow wine, Mel, one or more combination in cocoa powder, described mixture and adjuvant One quality parts ratio is 5-7：2.
Separately, the present invention also provides a kind of preparation method of the compositionss of the treatment of sexual dysfunction, prostatosis, including with Lower step：(1) weigh each formula components according to mass fraction, soaked respectively three times with wine spirit, single soak time is 10-15 days, stir once every 20-26h, divide and take soak；
(2) merge three soaks, call in adjuvant two mix homogeneously, boil 1-2h by slow fire, make conventional func wine.
Further, described adjuvant two is one of white sugar and citric acid or two kinds, described soak and adjuvant two Quality parts ratio is 3-5：1.5.
Further, when once being soaked, the mass fraction of wine spirit is the 2-4 of Chinese medicine formula gross mass number Times, when carrying out secondary immersion, the mass fraction of wine spirit is 1-3 times of Chinese medicine formula gross mass number, carries out three leachings During bubble, the mass fraction of wine spirit is 1-2 times of Chinese medicine formula gross mass number.
The invention has the beneficial effects as follows：
The application adds the product of warming and recuperating the kidney-YANG in the Chinese medicine of nourishing kidney yin, nourishing kidney yin, warming and recuperating the kidney-YANG, nourishing blood and promoting blood circulation, By the proportioning of each Chinese medicine formula of reasonable adjusting, make cloudy positive liter, positive cloudy help, biochemical infinite, meanwhile, compatibility helps spleen, stomach of waking up Product, make that middle gas is healthy and vigorous, change source abundance, invigorating the spleen and regulating the stomach, promote drug absorption, compatibility black hair, the product for the treatment of ulcer, liver protection is bright The common clinical manifestation symptom of mesh, prevention or regulation prostatosis, the application is in terms of pharmacology, each by effective regulation human body Organ dysfunction, reaches the therapeutical effect to prostatosis, and then effects a radical cure sexual dysfunction, has no side effect, evident in efficacy, cures Cycle is short.In addition, by extracting, decocting and soaking technology, making full use of the effective ingredient in Chinese medicine, after calling in adjuvant, gained Medicine delicate mouthfeel, aromatic taste, patient be easy to accept.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of not making creative work, all Belong to the scope of protection of the invention.
Embodiment one：
A kind of the treatment of sexual dysfunction, the compositionss of prostatosis, including following mass fraction formula components：
10 parts of Fructus Lycii, 10 parts of Fructus Corni, 20 parts of Radix Rehmanniae Preparata, 15 parts of Radix Angelicae Sinensis, 10 parts of the Cortex Eucommiae, 5 parts of Rhizoma Chuanxiong, 6 parts of Radix Codonopsis, Rhizoma Polygonati 10 parts, 10 parts of Radix Morindae Officinaliss, 10 parts of Rhizoma Curculiginises, 5 parts of Fructus Rosae Laevigatae, 5 parts of Fructus Psoraleae, 15 parts of Herba Epimedii, 6 parts of Fructus Schisandrae Chinensis, 5 parts of Semen Cuscutae, 2 parts of Cortex Cinnamomi, 23 parts of Semen Euryaless, 10 parts of Rhizoma Cibotii, 5 parts of Fructus Cnidii, 12 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Herba Cistanches, 8 parts of Radix Glycyrrhizae, 10 parts of the Radix Astragali, female 10 parts of chastity, 12 parts of Fructus Mori, 4 parts of Mulberry Piao sheath, 5 parts of Fructus Amomi Rotunduss, 3 parts of Herba Pogostemoniss, 5 parts of Pericarpium Citri Reticulatae, 3 parts of sea Piao sheath, 3 parts of Actinolitum, Radix Gentianae 3 parts of grass, 3 parts of Rhizoma Alismatis, 7 parts of Herba Taxilli, 3 parts of Fructus Tritici Levis, 2 parts of Corium Erinacei Seu Hemiechianuss, 8 parts of Cortex Moutan of Du, 5 parts of Rhizoma Anemones Altaicae and 1 part of Herba Asari.
A kind of described the treatment of sexual dysfunction, the compositionss of prostatosis preparation method as follows：
(1) according to mass fraction, Fructus Lycii, Fructus Corni, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Rosae Laevigatae, benefit are weighed respectively Bone fat, Semen Euryaless, Rhizoma Alismatis, Fructus Tritici Levis, Corium Erinacei Seu Hemiechianuss, Du's Cortex Moutan, Herba Asari, each formula mix homogeneously adds Chinese medicine formula gross mass The concentration of number 5.5 times amount is 85% ethanol, is heated to reflux, and extracts, and under conditions of vacuum is for 0.06Mpa, decompression is dense When being reduced to relative density for 1.02, obtain dry cream；
(2) step (1) is got dry extract and pulverized, crossed 100 mesh sieves, extracting screen underflow, obtain extracting compositionss；
(3) according to formula components, weigh respectively Rhizoma Chuanxiong, Radix Morindae Officinaliss, Herba Epimedii, Rhizoma Cibotii, Fructus Cnidii, Herba Taxilli, Rhizoma Curculiginises, five Taste, Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, Herba Cistanches, Radix Glycyrrhizae, Mulberry Piao sheath, Actinolitum, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, mix homogeneously, add The water of 1.5 times amount of Chinese medicine formula gross mass number, soaks 4h, boils 3h by slow fire, filters, and obtains decocting compositionss；
(4) according to formula components, Fructus Ligustri Lucidi, Fructus Mori, Radix Gentianae, Fructus Amomi Rotunduss, Herba Pogostemoniss, sea Piao sheath and Psychotria rubra (Lour.) Poir. Chang are weighed respectively Pu, pulverizes, and crosses 100 mesh sieves, extracting screen underflow, obtains powder composition；
(5) compositionss will be extracted, powder composition adds in decoction compositionss, and obtain mixture, mix 20min, then plus Enter adjuvant one, make conventional tablet, you can.
Described adjuvant one is yellow wine, and described mixture is 5 with the quality parts ratio of adjuvant one：2.
Embodiment two：
A kind of the treatment of sexual dysfunction, the compositionss of prostatosis, including following mass fraction formula components：
15 parts of Fructus Lycii, 12 parts of Fructus Corni, 25 parts of Radix Rehmanniae Preparata, 18 parts of Radix Angelicae Sinensis, 12 parts of the Cortex Eucommiae, 7 parts of Rhizoma Chuanxiong, 9 parts of Radix Codonopsis, Rhizoma Polygonati 15 parts, 13 parts of Radix Morindae Officinaliss, 12 parts of Rhizoma Curculiginises, 7 parts of Fructus Rosae Laevigatae, 8 parts of Fructus Psoraleae, 18 parts of Herba Epimedii, 7.5 parts of Fructus Schisandrae Chinensis, Semen Cuscutae 8 Part, 4 parts of Cortex Cinnamomi, 25 parts of Semen Euryaless, 13 parts of Rhizoma Cibotii, 7 parts of Fructus Cnidii, 14 parts of Fructus Alpiniae Oxyphyllae, 13 parts of Herba Cistanches, 10 parts of Radix Glycyrrhizae, the Radix Astragali 14 Part, 15 parts of Fructus Ligustri Lucidi, 14 parts of Fructus Mori, 8 parts of Mulberry Piao sheath, 8.5 parts of Fructus Amomi Rotunduss, 5 parts of Herba Pogostemoniss, 7 parts of Pericarpium Citri Reticulatae, 5 parts of sea Piao sheath, Actinolitum 4.5 parts, 4 parts of Radix Gentianae, 4.5 parts of Rhizoma Alismatis, 9 parts of Herba Taxilli, 5.5 parts of Fructus Tritici Levis, 4.5 parts of Corium Erinacei Seu Hemiechianuss, Du 10 parts of Cortex Moutan, Psychotria rubra (Lour.) Poir. Chang 7 parts of Pu and 3 parts of Herba Asari.
A kind of described the treatment of sexual dysfunction, the compositionss of prostatosis preparation method as follows：
(1) according to mass fraction, Fructus Lycii, Fructus Corni, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Rosae Laevigatae, benefit are weighed respectively Bone fat, Semen Euryaless, Rhizoma Alismatis, Fructus Tritici Levis, Corium Erinacei Seu Hemiechianuss, Du's Cortex Moutan, Herba Asari, each formula mix homogeneously adds Chinese medicine formula gross mass The concentration of number 7 times amount is 95% ethanol, is heated to reflux, and extracts, under conditions of vacuum is for 0.07Mpa, concentrating under reduced pressure To relative density be 1.08 when, obtain dry cream；
(2) step (1) is got dry extract and pulverized, crossed 200 mesh sieves, extracting screen underflow, obtain extracting compositionss；
(3) according to formula components, weigh respectively Rhizoma Chuanxiong, Radix Morindae Officinaliss, Herba Epimedii, Rhizoma Cibotii, Fructus Cnidii, Herba Taxilli, Rhizoma Curculiginises, five Taste, Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, Herba Cistanches, Radix Glycyrrhizae, Mulberry Piao sheath, Actinolitum, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, mix homogeneously, add The water of 4.5 times amount of Chinese medicine formula gross mass number, soaks 7h, boils 5h by slow fire, filters, and obtains decocting compositionss；
(4) according to formula components, Fructus Ligustri Lucidi, Fructus Mori, Radix Gentianae, Fructus Amomi Rotunduss, Herba Pogostemoniss, sea Piao sheath and Psychotria rubra (Lour.) Poir. Chang are weighed respectively Pu, pulverizes, and crosses 200 mesh sieves, extracting screen underflow, obtains powder composition；
(5) compositionss will be extracted, powder composition adds in decoction compositionss, and obtain mixture, mix 40min, then plus Enter adjuvant one, make conventional pill, you can.
Described adjuvant one is yellow wine, Mel, the mixture of cocoa powder, and described mixture with the quality parts ratio of adjuvant one is 7：2.
Embodiment three：
A kind of the treatment of sexual dysfunction, the compositionss of prostatosis, including following mass fraction formula components：
20 parts of Fructus Lycii, 15 parts of Fructus Corni, 30 parts of Radix Rehmanniae Preparata, 25 parts of Radix Angelicae Sinensis, 14 parts of the Cortex Eucommiae, 10 parts of Rhizoma Chuanxiong, 12 parts of Radix Codonopsis, Huang 20 parts of essence, 15 parts of Radix Morindae Officinaliss, 15 parts of Rhizoma Curculiginises, 10 parts of Fructus Rosae Laevigatae, 10 parts of Fructus Psoraleae, 20 parts of Herba Epimedii, 9 parts of Fructus Schisandrae Chinensis, Semen Cuscutae 12 parts, 5 parts of Cortex Cinnamomi, 26 parts of Semen Euryaless, 16 parts of Rhizoma Cibotii, 8 parts of Fructus Cnidii, 16 parts of Fructus Alpiniae Oxyphyllae, 16 parts of Herba Cistanches, sweet 12 parts, the Radix Astragali 16 Part, 16 parts of Fructus Ligustri Lucidi, 16 parts of Fructus Mori, 12 parts of Mulberry Piao sheath, 10 parts of Fructus Amomi Rotunduss, 6 parts of Herba Pogostemoniss, 10 parts of Pericarpium Citri Reticulatae, 7 parts of sea Piao sheath, Actinolitum 6 Part, 5 parts of Radix Gentianae, 6 parts of Rhizoma Alismatis, 11 parts of Herba Taxilli, 8 parts of Fructus Tritici Levis, 7 parts of Corium Erinacei Seu Hemiechianuss, Du 12 parts of Cortex Moutan, 9 parts of Rhizoma Anemones Altaicae and 4 parts of Herba Asari.
A kind of described the treatment of sexual dysfunction, the compositionss of prostatosis preparation method as follows：
(1) weigh each formula components according to mass fraction, soaked respectively three times with wine spirit, single soak time is 10 days, stir once every 20h, divide and take soak；
(2) merge three soaks, call in adjuvant two mix homogeneously, boil 1h by slow fire, make conventional func wine.
Described adjuvant two is white sugar, and described soak is 3 with the quality parts ratio of adjuvant two：1.5, once soaked When, the mass fraction of wine spirit is 2 times of Chinese medicine formula gross mass number, when carrying out secondary immersion, wine spirit Mass fraction is 1.5 times of Chinese medicine formula gross mass number, and when carrying out three immersions, the mass fraction of wine spirit is Chinese medicine 1 times of formula gross mass number.
Example IV：
A kind of the treatment of sexual dysfunction, the compositionss of prostatosis, including following mass fraction formula components：
12 parts of Fructus Lycii, 11 parts of Fructus Corni, 27 parts of Radix Rehmanniae Preparata, 22 parts of Radix Angelicae Sinensis, 13 parts of the Cortex Eucommiae, 9 parts of Rhizoma Chuanxiong, 11 parts of Radix Codonopsis, Huang 13 parts of essence, 14 parts of Radix Morindae Officinaliss, 12 parts of Rhizoma Curculiginises, 6 parts of Fructus Rosae Laevigatae, 9 parts of Fructus Psoraleae, 17 parts of Herba Epimedii, 8 parts of Fructus Schisandrae Chinensis, Semen Cuscutae 10.5 parts, 4 parts of Cortex Cinnamomi, 25 parts of Semen Euryaless, 14 parts of Rhizoma Cibotii, 7.5 parts of Fructus Cnidii, 13 parts of Fructus Alpiniae Oxyphyllae, 15.5 parts of Herba Cistanches, 9 parts of Radix Glycyrrhizae, 13 parts of the Radix Astragali, 12 parts of Fructus Ligustri Lucidi, 14.5 parts of Fructus Mori, 9 parts of Mulberry Piao sheath, 8 parts of Fructus Amomi Rotunduss, 5 parts of Herba Pogostemoniss, 8.5 parts of Pericarpium Citri Reticulatae, 6 parts of sea Piao sheath, 5 parts of Actinolitum, 5 parts of Radix Gentianae, 6 parts of Rhizoma Alismatis, 10 parts of Herba Taxilli, 8 parts of Fructus Tritici Levis, 6.5 parts of Corium Erinacei Seu Hemiechianuss, 9 parts of Cortex Moutan of Du, Psychotria rubra (Lour.) Poir. Chang 8 parts of Pu and 3.5 parts of Herba Asari.
A kind of described the treatment of sexual dysfunction, the compositionss of prostatosis preparation method as follows：
(1) weigh each formula components according to mass fraction, soaked respectively three times with wine spirit, single soak time is 15 days, stir once every 26h, divide and take soak；
(2) merge three soaks, call in adjuvant two mix homogeneously, boil 2h by slow fire, make conventional func wine.
Described adjuvant two is citric acid, and described soak is 5 with the quality parts ratio of adjuvant two：1.5, once soaked When, the mass fraction of wine spirit is 4 times of Chinese medicine formula gross mass number, when carrying out secondary immersion, wine spirit Mass fraction is 3 times of Chinese medicine formula gross mass number, and when carrying out three immersions, the mass fraction of wine spirit is joined for Chinese medicine 2 times of square gross mass number.
Comparative example one：
The present embodiment adopts identical preparation method with embodiment one, except for the difference that：
8 parts of Fructus Lycii, 18 parts of Fructus Corni, 35 parts of Radix Rehmanniae Preparata, 5 parts of Radix Angelicae Sinensis, 20 parts of the Cortex Eucommiae, 2 parts of Rhizoma Chuanxiong, 19 parts of Radix Codonopsis, Rhizoma Polygonati 5 Part, 20 parts of Radix Morindae Officinaliss, 6 parts of Rhizoma Curculiginises, 1 part of Fructus Rosae Laevigatae, 19 parts of Fructus Psoraleae, 25 parts of Herba Epimedii, 3 parts of Fructus Schisandrae Chinensis, 2 parts of Semen Cuscutae, meat 10 parts of osmanthus, 14 parts of Semen Euryaless, 3 parts of Rhizoma Cibotii, 2 parts of Fructus Cnidii, 10 parts of Fructus Alpiniae Oxyphyllae, 9 parts of Herba Cistanches, 5 parts of Radix Glycyrrhizae, 20 parts of the Radix Astragali, Fructus Ligustri Lucidi 5 parts of son, 6 parts of Fructus Mori, 2 parts of Mulberry Piao sheath, 15 parts of Fructus Amomi Rotunduss, 8 parts of Herba Pogostemoniss, 12 parts of Pericarpium Citri Reticulatae, 1 part of sea Piao sheath, 0.5 part of Actinolitum, Radix Gentianae 10 parts of grass, 9 parts of Rhizoma Alismatis, 16 parts of Herba Taxilli, 10 parts of Fructus Tritici Levis, 1 part of Corium Erinacei Seu Hemiechianuss, 1 part of Cortex Moutan of Du, 11 parts of Rhizoma Anemones Altaicae, Herba Asari 6 Part.
Comparative example two：
The present embodiment adopts identical preparation method with embodiment three, except for the difference that：
12 parts of Fructus Lycii, 11 parts of Fructus Corni, 27 parts of Radix Rehmanniae Preparata, 13 parts of the Cortex Eucommiae, 13 parts of Rhizoma Polygonati, 6 parts of Fructus Rosae Laevigatae, 9 parts of Fructus Psoraleae, 10.5 parts of Semen Cuscutae, 25 parts of Semen Euryaless, 7.5 parts of Fructus Cnidii, 13 parts of the Radix Astragali, 12 parts of Fructus Ligustri Lucidi, 14.5 parts of Fructus Mori, 8 parts of Fructus Amomi Rotunduss, Herba Pogostemoniss 5 parts, 6 parts of sea Piao sheath, 5 parts of Radix Gentianae, 6 parts of Rhizoma Alismatis, 8 parts of Fructus Tritici Levis, 6.5 parts of Corium Erinacei Seu Hemiechianuss, Du 9 parts of Cortex Moutan, 8 parts of Rhizoma Anemones Altaicae, 3.5 parts of Herba Asari.
Contrast experiment one：
300 be derived from institute of traditional Chinese medicine of Shandong Province by the handicapped patient of prostatosis induced, medical history is 10- 15 years, above-mentioned 300 patients are randomly divided into experimental group one to experimental group six.
The patient of experimental group one takes the tablet of embodiment one preparation, and instructions of taking is each 1 time of early daily, evening, and every time 3 Gram, continuously take 15-30 days.Experimental group two takes, to the patient of experimental group four, the medicament that embodiment two is prepared to example IV, Dosage, instructions of taking are identical with experimental group one with medicining cycle.Experimental group five, the patient of experimental group six take comparative example First, the medicament of comparative example two preparation, dosage, instructions of taking are identical with experimental group one with medicining cycle.Medicining cycle terminates Afterwards, above-mentioned patient is checked again, inspection result such as table 1：
Table 1：
Take a turn for the better (example) Invalid (example) Cure success rate (%)
Experimental group one 48 2 96
Experimental group two 49 1 98
Experimental group three 48 2 96
Experimental group four 47 3 94
Experimental group five 32 18 64
Experimental group six 26 24 52
Drawn by as above analysis of experimental data：Experimental group one is close and significantly high to the healing success rate of experimental group four In experimental group five, experimental group six that is to say, that nourishing kidney yin is combined with the product rational proportion of warming and recuperating the kidney-YANG, to sexual dysfunction There is significant curative effect, and cure cycle is short.Follow-up 3 months is carried out to the patient of experimental group one to experimental group four, does not find Rebound phenomenon.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment only wraps Containing an independent technical scheme, only for clarity, those skilled in the art should for this narrating mode of description Using description as an entirety, the technical scheme in each embodiment can also form those skilled in the art through appropriately combined Understandable other embodiment.

Claims (9)

1. a kind of the treatment of sexual dysfunction, prostatosis compositionss it is characterised in that：Become including following mass fraction formula Point：
Fructus Lycii 10-20 part, Fructus Corni 10-15 part, Radix Rehmanniae Preparata 20-30 part, Radix Angelicae Sinensis 15-25 part, Cortex Eucommiae 10-14 part, Rhizoma Chuanxiong 5-10 Part, Radix Codonopsis 6-12 part, Rhizoma Polygonati 10-20 part, Radix Morindae Officinaliss 10-15 part, Rhizoma Curculiginises 10-15 part, Fructus Rosae Laevigatae 5-10 part, Fructus Psoraleae 5-10 Part, Herba Epimedii 15-20 part, Fructus Schisandrae Chinensis 6-9 part, Semen Cuscutae 5-12 part, Cortex Cinnamomi 2-5 part, Semen Euryaless 23-26 part, Rhizoma Cibotii 10-16 part, Fructus Cnidii 5-8 part, Fructus Alpiniae Oxyphyllae 12-16 part, Herba Cistanches 10-16 part, Radix Glycyrrhizae 8-12 part, Radix Astragali 10-16 part, Fructus Ligustri Lucidi 10-16 part, Fructus Mori 12-16 part, Mulberry Piao sheath 4-12 part, Fructus Amomi Rotunduss 5-10 part, Herba Pogostemoniss 3-6 part, Pericarpium Citri Reticulatae 5-10 part, sea Piao sheath 3-7 part, Actinolitum 3- 6 parts, Radix Gentianae 3-5 part, Rhizoma Alismatis 3-6 part, Herba Taxilli 7-11 part, Fructus Tritici Levis 3-8 part, Corium Erinacei Seu Hemiechianuss 2-7 part, Du Cortex Moutan 8-12 part, Rhizoma Anemones Altaicae 5-9 part and Herba Asari 1-4 part.
2. a kind of the treatment of sexual dysfunction according to claim 1, prostatosis compositionss it is characterised in that：Bag Include following mass fraction formula components：
15 parts of Fructus Lycii, 12 parts of Fructus Corni, 25 parts of Radix Rehmanniae Preparata, 18 parts of Radix Angelicae Sinensis, 12 parts of the Cortex Eucommiae, 7 parts of Rhizoma Chuanxiong, 9 parts of Radix Codonopsis, Rhizoma Polygonati 15 Part, 13 parts of Radix Morindae Officinaliss, 12 parts of Rhizoma Curculiginises, 7 parts of Fructus Rosae Laevigatae, 8 parts of Fructus Psoraleae, 18 parts of Herba Epimedii, 7.5 parts of Fructus Schisandrae Chinensis, 8 parts of Semen Cuscutae, 4 parts of Cortex Cinnamomi, 25 parts of Semen Euryaless, 13 parts of Rhizoma Cibotii, 7 parts of Fructus Cnidii, 14 parts of Fructus Alpiniae Oxyphyllae, 13 parts of Herba Cistanches, 10 parts of Radix Glycyrrhizae, 14 parts of the Radix Astragali, 15 parts of Fructus Ligustri Lucidi, 14 parts of Fructus Mori, 8 parts of Mulberry Piao sheath, 8.5 parts of Fructus Amomi Rotunduss, 5 parts of Herba Pogostemoniss, 7 parts of Pericarpium Citri Reticulatae, 5 parts of sea Piao sheath, Actinolitum 4.5 Part, 4 parts of Radix Gentianae, 4.5 parts of Rhizoma Alismatis, 9 parts of Herba Taxilli, 5.5 parts of Fructus Tritici Levis, 4.5 parts of Corium Erinacei Seu Hemiechianuss, 10 parts of Cortex Moutan of Du, Rhizoma Anemones Altaicae 7 Part and 3 parts of Herba Asari.
3. a kind of the treatment of sexual dysfunction prepared as described in claim 1-2 any one, the compositionss of prostatosis Preparation method it is characterised in that：Comprise the steps：
(1) according to mass fraction, Fructus Lycii, Fructus Corni, the Cortex Eucommiae, Semen Cuscutae, Radix Rehmanniae Preparata, Rhizoma Polygonati, Fructus Rosae Laevigatae, Psoralen are weighed respectively Fat, Semen Euryaless, Rhizoma Alismatis, Fructus Tritici Levis, Corium Erinacei Seu Hemiechianuss, Du's Cortex Moutan, Herba Asari, each formula mix homogeneously adds ethanol, is heated to reflux, carries Take, obtain dry cream；
(2) step (1) is got dry extract and pulverized, crossed 100-200 mesh sieve, extracting screen underflow, obtain extracting compositionss；
(3) according to formula components, Rhizoma Chuanxiong, Radix Morindae Officinaliss, Herba Epimedii, Rhizoma Cibotii, Fructus Cnidii, Herba Taxilli, Rhizoma Curculiginises, the five tastes are weighed respectively Son, Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, Herba Cistanches, Radix Glycyrrhizae, Mulberry Piao sheath, Actinolitum, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Codonopsis, the Radix Astragali, mix homogeneously, add water leaching Bubble 4-7h, boils 3-5h by slow fire, filters, and obtains decocting compositionss；
(4) according to formula components, Fructus Ligustri Lucidi, Fructus Mori, Radix Gentianae, Fructus Amomi Rotunduss, Herba Pogostemoniss, sea Piao sheath and Rhizoma Anemones Altaicae, powder are weighed respectively Broken, cross 100-200 mesh sieve, extracting screen underflow, obtain powder composition；
(5) compositionss will be extracted, powder composition adds in decoction compositionss, and obtain mixture, mix 20-40min, add Adjuvant one, makes conventional tablet, pill or capsule, you can.
4. the preparation method of the compositionss of the treatment of sexual dysfunction according to claim 3, prostatosis, its feature exists In：In described step (1), described concentration of alcohol is 85～95%, and the mass fraction adding ethanol is Chinese medicine formula gross mass part 5.5-7 times of number, in described step (3), the mass fraction of addition water is 1.5-4.5 times of Chinese medicine formula gross mass number.
5. the preparation method of the compositionss of the treatment of sexual dysfunction according to claim 3, prostatosis, its feature exists In：Under conditions of vacuum is for 0.06-0.07Mpa, when being evaporated to relative density for 1.02-1.08, obtain dry cream.
6. the preparation method of the compositionss of the treatment of sexual dysfunction according to claim 3, prostatosis, its feature exists In：Described adjuvant one is yellow wine, Mel, one or more combination in cocoa powder, the mass fraction of described mixture and adjuvant one Than for 5-7：2.
7. a kind of the treatment of sexual dysfunction prepared as described in claim 1-2 any one, the compositionss of prostatosis Preparation method it is characterised in that：Comprise the steps：
(1) weigh each formula components according to mass fraction, soaked respectively three times with wine spirit, single soak time is 10- 15 days, stir once every 20-26h, divide and take soak；
(2) merge three soaks, call in adjuvant two mix homogeneously, boil 1-2h by slow fire, make conventional func wine.
8. the preparation method of the compositionss of the treatment of sexual dysfunction according to claim 7, prostatosis, its feature exists In：Described adjuvant two is one of white sugar and citric acid or two kinds, and described soak with the quality parts ratio of adjuvant two is 3-5：1.5.
9. the preparation method of the compositionss of the treatment of sexual dysfunction according to claim 7, prostatosis, its feature exists In：When once being soaked, the mass fraction of wine spirit is 2-4 times of Chinese medicine formula gross mass number, carries out secondary leaching During bubble, the mass fraction of wine spirit is 1-3 times of Chinese medicine formula gross mass number, and when carrying out three immersions, Fructus Vitis viniferae distills The mass fraction of wine is 1-2 times of Chinese medicine formula gross mass number.
CN201611185858.5A 2016-12-20 2016-12-20 Composition for treating sexual dysfunction and prostate disease and preparation method thereof Pending CN106390004A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1171970A (en) * 1997-06-26 1998-02-04 周淑琴 Health-care wine with antisenility function
CN1660404A (en) * 2005-01-19 2005-08-31 雷小平 Health product of preserving health, invigorating the kidney and supporting yang for male
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN102703289A (en) * 2012-06-01 2012-10-03 刘新江 Health-care wine for strengthening sexual function
CN104352635A (en) * 2014-11-30 2015-02-18 刘东海 Medicinal liquor for treating prostatic disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1171970A (en) * 1997-06-26 1998-02-04 周淑琴 Health-care wine with antisenility function
CN1660404A (en) * 2005-01-19 2005-08-31 雷小平 Health product of preserving health, invigorating the kidney and supporting yang for male
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN102703289A (en) * 2012-06-01 2012-10-03 刘新江 Health-care wine for strengthening sexual function
CN104352635A (en) * 2014-11-30 2015-02-18 刘东海 Medicinal liquor for treating prostatic disorders

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