CN106389978A - Medicine for treating fungal inflammations in gynecological department - Google Patents
Medicine for treating fungal inflammations in gynecological department Download PDFInfo
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- CN106389978A CN106389978A CN201610320970.9A CN201610320970A CN106389978A CN 106389978 A CN106389978 A CN 106389978A CN 201610320970 A CN201610320970 A CN 201610320970A CN 106389978 A CN106389978 A CN 106389978A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a medicine for treating fungal inflammations in gynecological department. The medicine is prepared from the following raw materials in parts by weight: 0.1-4 parts of borneol, 0.3-5 parts of minium, 0.2-10 parts of indigo naturalis, 1-15 parts of talcum powder, 0.3-15 parts of alum and 1-10 parts of radix stemonae. A preparation method comprises preparation of pills and preparation of a water aqua. The medicine provided by the invention has functions of killing bacteria and resisting insects, removing slough and promoting growth of tissue regeneration, clearing away heat and toxic materials, alleviating pain and relieving itching, and removing foreign smell. The medicine has a good effect on the fungal inflammations in the gynecological department; and in addition, the medicine can also take health care effects of moistening and tightening vaginae.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, it is particularly directed to medicine of gynaecology's fungoid inflammation and preparation method thereof.
Background technology
Gynaecological imflammation is the disease of female reproductive system, and cardinal symptom is based on leucorrhea increasing, and with vulva discomfort and pain of itching, the traditional Chinese medical science claims vaginal discharge diseases.The most common are vaginitis, cervicitis.
Normal healthy women vagina has natural defense function due to the feature of anatomical tissue to the intrusion of pathogen, closure as introitus, vagina front and rear wall is close to, hyperplasia under the influence of estrogen for the vaginal epithelial cell and cells of superficial layer angling, vagina acid-base degree keeps balance, so that the breeding of the pathogen of adaptation alkalescence is suppressed, and neck tube mucus is in alkalescence, when the natural defense function of vagina is destroyed, pathogen is easy to invade, and leads to colpitis.
There are aerobic bacteria and anaerobic bacteria to reside in vagina under normal circumstances, form normal vaginal flora.The ecological balance between vagina and flora is broken by any reason, also can formation condition pathogenic bacteria.Clinically common have：Bacterial vaginosis BV, monilial vaginitis, trichomonas vaginitis, senile vahinitis, infantile vaginitis.
Cervicitis is one of gynaecology's common disease, including portio vaginalis cervicis inflammation and canal of uterine cervix mucosal inflammation.Factor cervical canal portio vaginalis scaly epithelium is continued with vagina squamous phase, and colpitis all can cause portio vaginalis cervicis inflammation.Because canal of uterine cervix mucosal epithelium is simple columnar epithelium, anti-infection ability is poor, easily infects.Clinical common cervicitis is acute canal of uterine cervix mucositis, if acute cervicitis, without timely diagnosis and treatment or pathogen sustainable existence, may result in chronic cervicitis disease.
Content of the invention
The invention provides be directed to the medicine of gynaecology's fungoid inflammation and preparation method thereof.
For the medicine of gynaecology's fungoid inflammation, it is made up of the raw material of following weight ratio：0.1～4 part of borneol, 0.3～5 part of minium, 0.2～10 part of indigo naturalis, 1～15 part of talcum powder, 0.3～15 part of alum, 1～10 part of the tuber of stemona；
Optimize further, for the medicine of gynaecology's fungoid inflammation, be made up of the raw material of following weight ratio：1～3 part of borneol, 1～3 part of minium, 3～7 parts of indigo naturalis, 5～10 parts of talcum powder, 1～10 part of alum, 4～6 parts of the tuber of stemona；
For the medicine of gynaecology's fungoid inflammation, described borneol is the extracted crystallization being processed into of fresh cauline leaf of feverfew Blumea balsamifera；
For the medicine of gynaecology's fungoid inflammation, described indigo naturalis, the tuber of stemona are dry medicinal material；
The preparation of pill comprises the steps：
(1), weigh each raw material；
(2) borneol that, step (1) weighed, minium, indigo naturalis, talcum powder, alum powder；
(3), the powder sterilization that step (2) is obtained, places standby；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 5～10mm, with alcoholic extraction, prepared extract, then extract is concentrated into containing crude drug 1～2g/ml；
(5), the dregs of a decoction that step (4) produces are extracted with water, be 60～90 degree with the temperature that water extracts, prepared extract, then extract is concentrated into containing crude drug 1～2g/ml；
(6), the concentrate mixing pill that the pulvis that step (3) is obtained is obtained with step (4) and (5)；
(7), the pill parcel coat that step (6) is obtained, slow mechanism dissolved is in order to discharge medicine；
(8), the pill coat that step (7) is obtained is disposed silk thread, stay and be used for outside vagina pulling out residual drug pill.
The method that sterilization described in step (3) adopts is ultraviolet radiation disinfection；
The method that pill described in step (6) adopts is water-bindered pill-making method or moulds pill method, also can add auxiliary material it is ensured that pill intensity, not fugitive rotten；
In step (2), the fineness of powder processed is 100～200 mesh；
In step (8), wire length is 20～40cm, using silk or nylon cord, is fixed on pill using modes such as compacting, colligation, stickups, packs after sterilizing.
Aqua preparation comprises the steps：
(1), weigh each raw material；
(2) minium that, weighs step (1), indigo naturalis, alum, talcum powder mix dispersion respectively with water, place standby；
(3), the borneol that step (1) weighs is added menthol mixing, prepared mixed liquor；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 5～10mm, is extracted with water, is 60～90 degree with the temperature that water extracts, prepared extract, then extract is concentrated into containing crude drug 1～2g/ml, and placement is standby；
(5), the liquid mixing that step (2), (3), (4) are obtained, prepared mixed liquor；
(6), the mixed liquor that step (5) is obtained adds water and is configured to containing crude drug 0.1～1g/ml, obtains final product described aqua.
The present invention has the effect of uniqueness to gynaecological imflammation, can not only control inflammation from the cause of disease, has the effect of sterilized sterilizing moreover it is possible to effectively alleviate the pudendal pruritus symptom that inflammation is brought, and has functions that the moist and vagina that compacts.
Borneol taste is pungent, hardship, it is slightly cold, Delicate fragrance a surname dissipate, there is inducing resuscitation of having one's ideas straightened out, the effect for the treatment of sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, there is moist vagina, strengthen the effect of comfort, selected borneol is L-Borneol (L-Borneol), for the extracted crystallization being processed into of fresh cauline leaf of feverfew Blumea balsamifera Blumea balsami fera (L.) DC., it is more easy to be absorbed and nontoxic.
Minium also known as yellow lead, red powder, Zhu Fen, lead powder used in cosmetics, are to close refining with lead, sulphur, nitre etc. to form, have removing toxic substances, myogenic, the effect of promoting expectoration to arrest convulsion, often join alum external application, for treating skin sore, eczema tinea scabies, aphthae, suppurate in ear, vulvitis.
Indigo naturalis has clearing heat and detoxicating a, blood cooling and ecchymoses removing, the effect of purging intense heat arresting convulsion, for febrile virulent maculae, blood-head tells nosebleed, and pectoralgia hemoptysis, aphtha, mumps, larynx numbness, pediatric epilepsy scared, scorching effective for the adjoint endogenous toxic material of gynaecological imflammation.
Medicine-food grade talc powder selected by talcum powder, for native hydrous magnesium silicate, hydroaropic substance, white to pale white crystals powder, water insoluble, cold acid and alkali liquid, be in pharmaceutical preparation, to apply that wide lubricant is simultaneous to help stream antiplastering aid, its stable chemical nature, no toxicity, side effect, is during mixed material to play anti-stick effect for this invention effect, simultaneously works as lubricating vagina effect.
The alum selected in invention, crystallization for the processed refinement of mineral alunite, main chemical compositions are 12 hydrazine aluminum sulfate potassium, external application can be detoxified desinsection, eliminating dampness is antipruritic, there is good effect under band pruritus vulvae, leukorrhea, there is astriction simultaneously, have, to metroptosis, vaginal relaxation, the effect of compacting.
The tuber of stemona have relieving cough and reducing sputum, gentle lung qi, radiating induce sweat, the effect of desinsection and delousion, tuber of stemona desinsection and qi and blood is not lost, most useful for people, it is used for outward the disease such as head louse, body louse, pinworm, pudendal pruritus, roundworm disease, with kuh-seng with use, can removing dampness and detoxicating desinsection, cure mainly monilial vaginitis.
The present invention, can be sterilized pest-resistant from source for gynaecology's fungoid inflammation, and alum has extensive bactericidal action, and the tuber of stemona has treatment candidal vaginitis effect；Minium energy putrefaction-removing granulation-promoting, festering for private parts has good effect；Indigo naturalis has clearing heat and detoxicating effect；Borneol has the effect of the antalgesic-antipruritic of uniqueness, and has delicate fragrance and can go to eliminate the unusual smell；Alum also has the effect of hemostasis.
The present invention has sterilized pest-resistant, putrefaction-removing granulation-promoting, clearing heat and detoxicating, antalgesic-antipruritic, goes the effect that eliminates the unusual smell, has good effect to gynaecology's fungoid inflammation, and can also play the health-care effect of the moist vagina that compacts.
Specific embodiment
With reference to embodiments the principle and feature of the present invention is described, example is served only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1
Parts by weight of raw materials：2 parts of borneol, 2 parts of minium, 5 parts of indigo naturalis, 7 parts of talcum powder, 7 parts of alum, 5 parts of the tuber of stemona；
Described borneol is the extracted crystallization being processed into of fresh cauline leaf of feverfew Blumea balsamifera.
Described indigo naturalis, the tuber of stemona are dry medicinal material；
Prepared by pill：
(1), weigh each raw material；
(2) borneol that, weighs step (1), minium, indigo naturalis, talcum powder, alum powder, the fineness of powder processed is 200 mesh；
(3), the powder that step (2) is obtained carries out ultraviolet radiation disinfection sterilizing, places standby；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 5mm, with alcoholic extraction, prepared extract, then extract is concentrated into 2g/ml containing crude drug；
(5), the dregs of a decoction that step (4) produces are extracted with water, be 90 degree with the temperature that water extracts, prepared extract, then extract is concentrated into 2g/ml containing crude drug；
(6), the concentrate that pulvis that step (3) be obtained is obtained with step (4) and (5) mixes pill using water-bindered pill-making method；
(7), the pill parcel coat that step (6) is obtained；
(8), the pill coat that step (7) is obtained is disposed silk thread, stay line length to be 20cm.
Embodiment 2
Raw material preparation is same as Example 1, then prepares aqua.
Aqua preparation comprises the steps：
(1), weigh each raw material；
(2) minium that, weighs step (1), indigo naturalis, alum, talcum powder mix dispersion respectively with water, place standby；
(3), the borneol that step (1) weighs is added menthol mixing, prepared mixed liquor；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 10mm, is extracted with water, is 80 degree with the temperature that water extracts, prepared extract, then extract is concentrated into 1g/ml containing crude drug, and placement is standby；
(5), the liquid mixing that step (2), (3), (4) are obtained, prepared mixed liquor；
(6), the mixed liquor that step (5) is obtained adds water and is configured to 1g/ml containing crude drug, obtains final product described aqua.
Embodiment 3
Parts by weight of raw materials：1 part of borneol, 1 part of minium, 4 parts of indigo naturalis, 10 parts of talcum powder, 10 parts of alum, 6 parts of the tuber of stemona；
Described borneol is the extracted crystallization being processed into of fresh cauline leaf of feverfew Blumea balsamifera.
Described indigo naturalis, the tuber of stemona are dry medicinal material；
Prepared by pill：
(1), weigh each raw material；
(2) borneol that, weighs step (1), minium, indigo naturalis, talcum powder, alum powder, the fineness of powder processed is 150 mesh；
(3), the powder that step (2) is obtained carries out ultraviolet radiation disinfection sterilizing, places standby；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 7mm, with alcoholic extraction, prepared extract, then extract is concentrated into 1g/ml containing crude drug；
(5), the dregs of a decoction that step (4) produces are extracted with water, be 90 degree with the temperature that water extracts, prepared extract, then extract is concentrated into 2g/ml containing crude drug；
(6), the concentrate that pulvis that step (3) be obtained is obtained with step (4) and (5) mixes pill using water-bindered pill-making method；
(7), the pill parcel coat that step (6) is obtained；
(8), the pill coat that step (7) is obtained is disposed silk thread, stay line length to be 25cm.
Embodiment 4
Raw material preparation is same as Example 3, then prepares aqua.
Aqua preparation comprises the steps：
(1), weigh each raw material；
(2) minium that, weighs step (1), indigo naturalis, alum, talcum powder mix dispersion respectively with water, place standby；
(3), the borneol that step (1) weighs is added menthol mixing, prepared mixed liquor；
(4) tuber of stemona, weighing step (1) is cataclasm, and cataclasm length is 6mm, is extracted with water, is 60 degree with the temperature that water extracts, prepared extract, then extract is concentrated into 1.5g/ml containing crude drug, and placement is standby；
(5), the liquid mixing that step (2), (3), (4) are obtained, prepared mixed liquor；
(6), the mixed liquor that step (5) is obtained adds water and is configured to 0.6g/ml containing crude drug, obtains final product described aqua.
Claims (10)
1. it is directed to the medicine of gynaecology's fungoid inflammation it is characterised in that being made up of the raw material of following weight ratio：Borneol 0.1～4%,
Minium 0.3～5%, indigo naturalis 0.2～10%, talcum powder 1～15%, alum 0.3～15%, the tuber of stemona 1～10%.
2. the medicine for gynaecology's fungoid inflammation according to claim 1 is it is characterised in that former by following weight ratio
Material is made：Borneol 1～3%, minium 1～3%, indigo naturalis 3～7%, talcum powder 5～10%, alum 1～10%, the tuber of stemona 4～6%.
3. medicine according to claim 1 is it is characterised in that described borneol is the fresh cauline leaf of feverfew Blumea balsamifera
The extracted crystallization being processed into.
4. medicine according to claim 1 is it is characterised in that described indigo naturalis, the tuber of stemona are dry medicinal material.
5. the preparation method of the medicine according to claim 1,2,3 or 4 is it is characterised in that under the preparation of pill includes
State step：
(1), weigh each raw material；
(2) borneol that, step (1) weighed, minium, indigo naturalis, talcum powder, alum powder；
(3), the powder sterilization that step (2) is obtained, places standby；
(4) tuber of stemona, weighing step (1) is cataclasm, with alcoholic extraction, prepared extract, then by extract be concentrated into containing crude drug 1～
2g/ml；
(5), the dregs of a decoction that step (4) produces are extracted with water, prepared extract, then extract is concentrated into containing crude drug 1～2g/ml；
(6), the concentrate mixing pill that the pulvis that step (3) is obtained is obtained with step (4) and (5)；
(7), the pill parcel coat that step (6) is obtained；
(8), the pill coat that step (7) is obtained is disposed silk thread.
6. the medicine according to claim 1,2,3 or 4 preparation method it is characterised in that aqua preparation include following
Step：
(1), weigh each raw material；
(2) minium that, weighs step (1), indigo naturalis, alum, talcum powder mix dispersion respectively with water, place standby；
(3), the borneol that step (1) weighs is added menthol mixing, prepared mixed liquor；
(4) tuber of stemona, weighing step (1) is cataclasm, is extracted with water, prepared extract, then by extract be concentrated into containing crude drug 1～
2g/ml, places standby；
(5), the liquid mixing that step (2), (3), (4) are obtained, prepared mixed liquor；
(6), the mixed liquor that step (5) is obtained adds water and is configured to containing crude drug 0.1～1g/ml, obtains final product described aqua.
7. preparation method according to claim 5 is it is characterised in that the side that adopts of sterilization described in step (3)
Method is ultraviolet radiation disinfection.
8. preparation method according to claim 5 is it is characterised in that the method that the pill described in step (6) adopts is
Water-bindered pill-making method or mould pill method.
9. preparation method according to claim 5 is it is characterised in that the fineness of the middle powder processed of step (2) is 100～200
Mesh.
10. the preparation method according to claim 5 or 6 is it is characterised in that described cataclasm length is 5～10mm；
The described temperature with water extraction is 60～90 degree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610320970.9A CN106389978A (en) | 2016-05-16 | 2016-05-16 | Medicine for treating fungal inflammations in gynecological department |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610320970.9A CN106389978A (en) | 2016-05-16 | 2016-05-16 | Medicine for treating fungal inflammations in gynecological department |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389978A true CN106389978A (en) | 2017-02-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610320970.9A Pending CN106389978A (en) | 2016-05-16 | 2016-05-16 | Medicine for treating fungal inflammations in gynecological department |
Country Status (1)
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071093A (en) * | 2013-01-17 | 2013-05-01 | 遵义县南白镇华南药房 | Medicine for treating gynecological diseases |
| CN105055493A (en) * | 2015-08-12 | 2015-11-18 | 孟岩 | Medicine for treating gynecological diseases and preparation method and application thereof |
-
2016
- 2016-05-16 CN CN201610320970.9A patent/CN106389978A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071093A (en) * | 2013-01-17 | 2013-05-01 | 遵义县南白镇华南药房 | Medicine for treating gynecological diseases |
| CN105055493A (en) * | 2015-08-12 | 2015-11-18 | 孟岩 | Medicine for treating gynecological diseases and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨培民等: "《最新中成药手册》", 30 November 2014, 山东科学技术出版社 * |
| 穆俊英等: ""青黛散治疗妇科炎症68例"", 《甘肃中医学院学报》 * |
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Application publication date: 20170215 |