CN105055493A - Medicine for treating gynecological diseases and preparation method and application thereof - Google Patents
Medicine for treating gynecological diseases and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of medicine, and provides a medicine for treating gynecological diseases as well as a preparation method and application thereof. The medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of dried alum, 1-10 parts of alum, 1-20 parts of minium, 1-20 parts of calcined borax, 1-20 parts of frankincense, 1-20 parts of myrrh, 1-20 parts of cutch, 1-20 parts of borneol and 1-20 parts of indigo naturalis. The medicine composition is prepared according to the conventional pharmaceutical manufacturing method in the traditional Chinese pharmacology into a vaginal administration preparation, and can be used for preparing medicine for treating dysmenorrhea, peculiar smell, itching, various vaginitis, cervicitis, cervical erosion, pelvic inflammation, myoma of uterus, ovarian cyst and ovarian polyp.
Description
Technical field
The invention belongs to drug world, relate to one and treat colpitic pharmaceutical composition, be specifically related to a kind of by being the pharmaceutical composition that raw material is made for dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis.
Background technology
Vagina feature is open, dark moist (vaginal mucosa secretion leucorrhea liquid), temperature is at the environment of 37 DEG C, also be that easily attractive and applicable various toxin (pathogenic bacterium) grow and the place of concealing, adding effect (sexual life, fertility, the artificial abortion of external force, immunity degradation etc.) cause various toxin (pathogenic bacterium) to be growing on and on, just there will be various gynaecological problem.
In this case, medicine provided by the invention is the direct drug-delivery preparation of vagina, the Therapeutic Method of medicine first thoroughly changes intravaginal environment, be dry the environment change of intravaginal humidity, salubrious environment, namely fully adsorbs intravaginal moisture (pulling out dry), and suppress its vaginal mucosa secreting liquid in the short time simultaneously, cause various toxin cannot survive in vivo, and then kill various toxin (pathogenic bacterium), play a multiplier role effect.
Medicine of the present invention is the direct drug-delivery preparation of vagina, Chinese medicine ingredients contained by it has adsorption function, can the evil meat in body, rotten to the corn tissue, various toxin (pathogenic bacterium) is removed and is completely adsorbed external, can not allow remain in vivotoxin (pathogenic bacterium) revive, thus reach radical cure gynopathic object.
Use before sleeping in the evening, and after medication, 1min starts disintegrate, retains 48h in vivo, adsorb uterine cavity endotoxin and pathogenic bacterium simultaneously, and give full play to the performance of Chinese medicine, because these product are the direct administrations of vagina, can to go directly focus, allow Chinese medicine fully in vivo local play powerful effect.
Medicine of the present invention is that inventor develops for many years meticulously, is mainly used in treating dysmenorrhea, abnormal flavour, pruritus, various vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease, hysteromyoma, ovarian cyst, ovary polyps.Show after deliberation, medicine of the present invention has good therapeutic effect to vaginitis.
Summary of the invention
The object of this invention is to provide one and treat vaginitis, the pharmaceutical composition of cervical erosion.
Another object of the present invention is to provide the preparation method of this pharmaceutical composition.
Present invention also offers the pharmaceutical applications of this pharmaceutical composition.
The object of the invention is to realize in the following manner:
A kind of to treat colpitic pharmaceutical composition be made up of the raw material of following weight portion: dried Alumen 1 ~ 10 weight portion, Alumen 1 ~ 10 weight portion, Plumbum preparatium 1 ~ 20 weight portion, Borax(calcined) 1 ~ 20 weight portion, Olibanum 1 ~ 20 weight portion, Myrrha 1 ~ 20 weight portion, catechu 1 ~ 20 weight portion, Borneolum Syntheticum 1 ~ 20 weight portion, Indigo Naturalis 1 ~ 20 weight portion.
This pharmaceutical composition is preferably made up of the raw material of following weight portion: dried Alumen 18 weight portion, Alumen 18 weight portion, Plumbum preparatium 15 weight portion, Borax(calcined) 15 weight portion, Olibanum 13 weight portion, Myrrha 13 weight portion, catechu 10 weight portion, Borneolum Syntheticum 4 weight portion, Indigo Naturalis 1 weight portion.
This pharmaceutical composition is preferably made up of the raw material of following weight portion: dried Alumen 15 weight portion, Alumen 15 weight portion, Plumbum preparatium 12 weight portion, Borax(calcined) 10 weight portion, Olibanum 10 weight portion, Myrrha 8 weight portion, catechu 10 weight portion, Borneolum Syntheticum 5 weight portion, Indigo Naturalis 2 weight portion.
This pharmaceutical composition is preferably made up of the raw material of following weight portion: dried Alumen 20 weight portion, Alumen 5 weight portion, Plumbum preparatium 8 weight portion, Borax(calcined) 10 weight portion, Olibanum 8 weight portion, Myrrha 8 weight portion, catechu 8 weight portion, Borneolum Syntheticum 2 weight portion, Indigo Naturalis 1 weight portion.
Described pharmaceutical composition adopts pharmaceutical methods conventional in pharmacy to be prepared into vagina administration preparation.
Described pharmaceutical composition is preferably adopted and is prepared with the following method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, and mixing, is pressed into vaginal tablet, obtains final product.
Described pharmaceutical composition can be used for preparation treatment dysmenorrhea, abnormal flavour, pruritus medicine.
Described pharmaceutical composition can be used for preparing the application in treatment pelvic inflammatory disease, cervicitis, cervical erosion medicine.
Described pharmaceutical composition can be used for preparing the application in treatment hysteromyoma medicine.
Described pharmaceutical composition can be used for preparing the application in treatment ovarian cyst, ovary polyps medicine.
Technique effect of the present invention is verified by following experimentation:
experiment one: the experimentation that medicine of the present invention affects cervical erosion rat model
1 material
1.1 animal
SD rat, female, body weight 200 ~ 220g; KM mice, female, 20 ~ 22g; Thered is provided by Liaoning University of TCM's Experimental Animal Center.
1.2 reagent and reagent
Medicine of the present invention: dried Alumen 286g, Alumen 71.5g, Plumbum preparatium 114.4g, Borax(calcined) 143g, Olibanum 114.4g, Myrrha 114.4g, catechu 114.4g, Borneolum Syntheticum 28.6g, Indigo Naturalis 14.3g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared A: Alumen 100g, Plumbum preparatium 160g, Borax(calcined) 200g, Olibanum 160g, Myrrha 160g, catechu 160g, Borneolum Syntheticum 40g, Indigo Naturalis 20g; Method for making: get Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared B: dried Alumen 308g, Plumbum preparatium 123.2g, Borax(calcined) 154g, Olibanum 123.2g, Myrrha 123.2g, catechu 123.2g, Borneolum Syntheticum 30.8g, Indigo Naturalis 15.4g; Method for making: get dried Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared C: dried Alumen 322g, Alumen 80.5g, Borax(calcined) 161g, Olibanum 128.8g, Myrrha 128.8g, catechu 128.8g, Borneolum Syntheticum 32.2g, Indigo Naturalis 16.1g; Method for making: get dried Alumen, Alumen, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared D: dried Alumen 333.2g, Alumen 83.3g, Plumbum preparatium 133.3g, Olibanum 133.3g, Myrrha 133.3g, catechu 133.3g, Borneolum Syntheticum 33.3g, Indigo Naturalis 16.7g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared E: dried Alumen 322g, Alumen 80.5g, Plumbum preparatium 128.8g, Borax(calcined) 161g, Myrrha 128.8g, catechu 128.8g, Borneolum Syntheticum 32.2g, Indigo Naturalis 16.1g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared F: dried Alumen 322g, Alumen 80.5g, Plumbum preparatium 128.8g, Borax(calcined) 161g, Olibanum 128.8g, catechu 128.8g, Borneolum Syntheticum 32.2g, Indigo Naturalis 16.1g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared G: dried Alumen 322g, Alumen 80.5g, Plumbum preparatium 128.8g, Borax(calcined) 161g, Olibanum 128.8g, Myrrha 128.8g, Borneolum Syntheticum 32.2g, Indigo Naturalis 16.1g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared H: dried Alumen 294g, Alumen 73.5g, Plumbum preparatium 117.6g, Borax(calcined) 147g, Olibanum 117.6g, Myrrha 117.6g, catechu 117.6g, Indigo Naturalis 14.7g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared I: dried Alumen 290g, Alumen 72.5g, Plumbum preparatium 116g, Borax(calcined) 145g, Olibanum 116g, Myrrha 1164g, catechu 116g, Borneolum Syntheticum 29g; Method for making: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Drugs compared J: Radix Scutellariae 108.5g, Cortex Phellodendri 124g, Rhizoma Coptidis 310g, Olibanum 15.5g, Myrrha 17g, Galla Chinensis 18.6g, Radix Sophorae Flavescentis 23.2g, Fructus Cnidii 55.8g, Indigo Naturalis 62g, dried Alumen 58.9g, catechu 24.8g, Pseudobulbus Bletillae (Rhizoma Bletillae) 31g, Herba Menthae 27.9g, Matrii Sulfas Exsiccatus 29.4g, Borneolum Syntheticum 31g, Borax 29.4g, Pulvis concha Mactrae 31g; Method for making: get Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Olibanum, Myrrha, Galla Chinensis, Radix Sophorae Flavescentis, Fructus Cnidii, Indigo Naturalis, dried Alumen, catechu, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Matrii Sulfas Exsiccatus, Borneolum Syntheticum, Borax, Pulvis concha Mactrae, mix homogeneously, is ground into fine powder, adds adjuvant, mixing, is pressed into vaginal tablet 1000; This drug prescription and method for making are reference application numbers is 200910011558.9, and application publication number is technology disclosed in the Chinese invention patent of CN101549099A.
XIAOMI SHUAN, TongHua WanTong Pharmacy Co., Ltd, the accurate word Z20025663 of traditional Chinese medicines;
Arabic gum, Tai'an tripartite confrontation Jiao Ye company produces, and carrageenin is SIGMA Products, nutrient agar, nutrient broth medium, husky fort agar culture medium, purchased from institute for drug control, Liaoning Province, with reference to preparation is described.
1.3 instrument OLYMPUSAX70 type photomicrographic system, Japanese O-LYMPUS Optical Co., Ltd; Leitzl512 type microtome, JA1003 type electronic balance.
1.4 strain escherichia coli, staphylococcus aureus, Candida albicans is institute for drug control, Liaoning Province pharmacological room and provides.
2 methods
The foundation of 2.1 cervical erosion models
Healthy female rat 140, be divided at random blank group, model group, medicine group of the present invention, drugs compared A group, drugs compared B group, drugs compared C group, drugs compared D group, drugs compared E group, drugs compared F group, drugs compared G group, drugs compared H group, drugs compared I group, drugs compared J group, XIAOMI SHUAN group.According to document (Cheng Youbin, Pan Honglin. the position screening study of Rhizoma Fagopyri Dibotryis anti-inflammatory activity. time precious traditional Chinese medical science traditional Chinese medicines, 2009,20 (9): 2219 ~ 2220.) method, gets phenol 30mL, arabic gum 40g, distilled water 50mL is made into Hydroxybenzene mucilage, enter rat vagina with taper venotomy pin and inject Hydroxybenzene mucilage 0.2mL, 1 time/3 days, totally 4 times.Modeling success after, start drug treatment, medicine group of the present invention is water-soluble make suspension after adopt taper venotomy pin enter vagina inject, according to 0.2gkg
-1dosed administration, XIAOMI SHUAN group vagina is filled in, dosage 0.3gkg
-1, 1 times/day, matrix group gives the treatment of corresponding substrate, successive administration 7 days, within the 8th day, puts to death animal, gets its vagina, uterus perusal carry out histopathologic examination.
2.2 xylol cause the impact of mice auricle swelling
Reference literature (Wang Zhenfu. the experimentation of Herba Verbenae antiinflammatory action. China National folk medicine, 2009,18:8 ~ 9.), get KM mice 130, be divided into blank group, medicine group of the present invention, drugs compared A group, drugs compared B group, drugs compared C group, drugs compared D group, drugs compared E group, drugs compared F group, drugs compared G group, drugs compared H group, drugs compared I group, drugs compared J group, XIAOMI SHUAN group at random.Each group respectively external give distilled water 0.2mL/10g, medicine 0.4gkg of the present invention
-1, drugs compared A0.4gkg
-1, drugs compared B0.4gkg
-1, drugs compared C0.4gkg
-1, drugs compared D0.4gkg
-1, drugs compared E0.4gkg
-1, drugs compared F0.4gkg
-1, drugs compared G0.4gkg
-1, drugs compared H0.4gkg
-1, drugs compared I0.4gkg
-1, drugs compared J0.4gkg
-1, XIAOMI SHUAN 0.4gkg
-1, successive administration 3d, 1h after last administration, be applied to the wide two sides of mouse right ear with 50 μ L dimethylbenzene and cause inflammation, left auricle in contrast, cuts two ears after 4h, get auricle, weigh with diameter 6mm card punch, represents the intensity of inflammatory reaction with two ear weight differences, calculates suppression ratio.
Suppression ratio (%)=[1-(administration group two auricle weight difference/blank group two auricle weight differences)] × 100%
2.3 cause the impact of foot swelling to rat carrageenan
SD rat 130 is divided at random model group, medicine group of the present invention, drugs compared A group, drugs compared B group, drugs compared C group, drugs compared D group, drugs compared E group, drugs compared F group, drugs compared G group, drugs compared H group, drugs compared I group, drugs compared J group, XIAOMI SHUAN group.1% Carrageenan solution 0.1mL is injected right hind sole subcutaneous, then respectively organize external respectively and give distilled water, medicine 0.4gkg of the present invention
-1, drugs compared A0.4gkg
-1, drugs compared B0.4gkg
-1, drugs compared C0.4gkg
-1, drugs compared D0.4gkg
-1, drugs compared E0.4gkg
-1, drugs compared F0.4gkg
-1, drugs compared G0.4gkg
-1, drugs compared H0.4gkg
-1, drugs compared I0.4gkg
-1, drugs compared J0.4gkg
-1, XIAOMI SHUAN 0.4gkg
-1, coating medicine-feeding, after administration 30min, measures the following volume of rat right hind leg ankle joint with sufficient plethysmometer.30min after ip administration, injects right hind sole by 1% Carrageenan solution 0.1mL subcutaneous, and record causes the following volume of scorching front and back different time right hind ankle joint.
Swelling rate (%)=(cause scorching before and after sufficient sole of the foot capacity difference/cause inflammation before sufficient sole of the foot volume) × 100%
3 results
The therapeutical effect of 3.1 pairs of rat cervical erosion
Dissect rat and get uterine cancer cell perusal, model group vagina, cervical tissue is congested, edema.Treatment group all has improvement to a certain degree.Pathologic finding, blank group vagina and uterine cancer cell have no obvious pathological changes, and model group all occurs that vaginal mucosal epithelium inflammatory cell invades profit, thickens.Medicine group inflammatory cell of the present invention is invaded profit and is obviously alleviated, and the rotten to the corn area of uterine mucosa comparatively XIAOMI SHUAN obviously reduces; Drugs compared A group is invaded profit to drugs compared J group inflammatory cell and is obviously alleviated, but the rotten to the corn area of uterine mucosa is obviously greater than XIAOMI SHUAN group, the results are shown in Table 1-1.
Table 1-1 two groups of medicines are to the pathological examination of uterine erosion rat model
3.2 xylol cause the impact of mice auricle swelling
Result shows, the ear swelling that medicine xylol of the present invention causes has obvious inhibitory action, wherein compared with blank group, low dose group has significant difference (P<0.05), middle and high dosage group has significant differences (P<0.01), and difference is in Table 1-2.Compare with XIAOMI SHUAN group, medicine group of the present invention has significant difference (P<0.05), points out the effect of Drug inhibition mice caused by dimethylbenzene xylene auricle edema of the present invention to be better than XIAOMI SHUAN group.Compare with XIAOMI SHUAN group, drugs compared A group suppresses the action effect of mice caused by dimethylbenzene xylene auricle edema to be slightly worse than XIAOMI SHUAN group to drugs compared J group.
Table 1-2 medicine xylol of the present invention cause mice auricle swelling impact (
± s)
Note: compare with blank group, * P<0.05, * * P<0.01; Compare with XIAOMI SHUAN agent group, #P<0.05
3.3 cause the impact of foot swelling to rat carrageenan
Table 1-3 result shows, medicine of the present invention has the swelling effect significantly suppressing carrageenin to cause, and day part, compared with model control group, all has obvious difference.Day part, medicine group of the present invention compares with XIAOMI SHUAN group, all has significant difference (P<0.05), points out medicine of the present invention to cause the impact of foot swelling to be better than XIAOMI SHUAN on rat carrageenan.Drugs compared A group also has the swelling effect suppressing carrageenin to cause to drugs compared J group, but compares with XIAOMI SHUAN group, there was no significant difference, and action effect is slightly worse than XIAOMI SHUAN group.
Table 1-3 medicine of the present invention on rat carrageenan cause foot swelling impact (
± s)
Note: compare with model group, * P<0.05, * * P<0.01; Compare with XIAOMI SHUAN agent group, #P<0.05
4 discuss and conclusion
This result of study shows, the therapeutical effect of medicine of the present invention to cervical erosion rat model is remarkable, the effect of antiinflammatory and vitro inhibition escherichia coli and Candida albicans is all better than XIAOMI SHUAN, and be better than drugs compared A to drugs compared J, illustrate that the compatibility in pharmaceutical composition of the present invention between each flavour of a drug is superior, indispensable, the combination between each flavour of a drug creates obvious synergistic function.
experiment two: Drug therapy chronic cervicitis of the present invention, vaginitis observation of curative effect
The chronic cervicitis of in JIUYUE, 2013 to 2014 outpatient clinic in year June, vaginitis patient 70 example are adopted to Drug therapy of the present invention, and follow up a case by regular visits to the routine patient in 65 wherein, observe, and existing report is as follows.
1 data and method
1.1 physical data 65 examples are out-patient, 26 years old ~ 47 years old age.Wherein vaginitis 35 example, chronic cervicitis 30 example.All once, treat more than 3 times with other drug before patient assessment and do not heal.
1.2 methods adopt Drug therapy of the present invention, stop 3d starting use with clean period 3d or artificial abortion vaginal hemorrhage, and with preposition posterior fornix of vagina portion of sleeping evening, every evening 1,6 is 1 course for the treatment of, prohibitive life during medication.After terminating the course for the treatment of and clean period afterwards institute check.
1.3 curative effect judging standard recoveries from illness: clinical symptoms, sign all disappear; Effective: clinical symptoms, sign all obviously alleviate; Effective: clinical symptoms, sign alleviate to some extent; Invalid: clinical symptoms, sign are constant.
2 results
In Table 2-1.
Table 2-1 clinical practice Drug therapy result of the present invention example (%)
Small number of patients has local response: vagina burning sensation 1 example, disappears after drug withdrawal, without the need to special handling.
3 discuss and conclusion
Drug therapy chronic cervicitis of the present invention, vaginitis, easy to use, safe, side reaction is little, curative effect is reliable, be worthy of popularization.
experiment three: the random parallel control research of Drug therapy ovarian cyst of the present invention
1 materials and methods
1.1 research design
Adopt random parallel control method, select inpatient 100 example at institute of traditional Chinese medicine's department of obstetrics and gynecology; Scheme obtains the approval of Ethics Committee of institute of traditional Chinese medicine and tracking control of full process.
1.2 random packet
Include case in and be divided into two groups at random by drawing method.
1.3 inclusive criteria
1. 20 ~ 50 years old age, women.2. treat first 6 weeks cysts and be in continuous growth state.3. informed consent, signature Informed Consent Form.
1.4 exclusion standard
1. other diseases, syndrome or complication.2. associated treatment has been accepted and possibility influential effect observation index.3. with the observation of possibility influential effect index, other physiology judged or pathological condition.4. severe cardiac, liver, renal damage affect drug metabolism.5. characterizing population group's (anemia of pregnant woman, psychosis, be dangerously ill or the terminal stage of a disease).Before including in, accept Drug therapy, meet inclusive criteria through eluting after date, be not considered as Excluded cases.
1.5 exit standard
1. not by the measure of regulation Intervention, curative effect cannot be judged.2. data does not judge curative effect, safety completely without method.3. serious adverse reaction, complication, special physiological change etc., are difficult to continual cure.(untoward reaction person includes bad reflection statistics in).4. the medicine that affects the treatment is used.Exit case and include efficacy determination in by curative effect when exiting.
1.6 diagnostic criteria
1.6.1 Western medicine diagnose according to " new Chinese medicine guideline of clinical investigations " (Zheng Xiao cornel. new Chinese medicine guideline of clinical investigations ［ M ］. Beijing: China Medical Science Press, 2002:243-244.).
1.6.2 tcm diagnosis according to " Chinese medical disease Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine. Chinese medical disease Standardization of diagnosis and curative effect ［ M ］. Nanjing: publishing house of Nanjing University, 1994:244-245).
It was 1 course for the treatment of that 1.7 Therapeutic Method two groups treat 28d all continuously.
1.7.1 matched group
GUIZHI FULING JIAONANG (Kangyuan Pharmaceutical Co., Ltd., Jiangsu Prov, accurate word Z10950005, the 0.31g/ grain of traditional Chinese medicines), 0.93g/ time, 3 times/d, menstruation terminates 2d and starts to take medicine.
1.7.2 treatment group
Adopt Drug therapy of the present invention, start use with after clean period 2d, with preposition posterior fornix of vagina portion of sleeping evening, every evening 1,14 is 1 course for the treatment of, prohibitive life during medication.After terminating the course for the treatment of and clean period afterwards institute check.
1.8 observation index
Clinical symptoms, blood plasma follicle stimulating hormone (FSH), progesterone (P), estradiol (E2), diameter of tumor, hemodynamic index, untoward reaction.
1.9 efficacy determination
Continuous treatment 3 course for the treatment of (90d), judges curative effect.With reference to " Chinese medical disease Standardization of diagnosis and curative effect ".Recovery from illness: clinical symptoms disappears completely, disappears through ultrasound diagnosis cyst.Effective: clinical symptoms partial disappearance, reduce > 1/2 through ultrasound diagnosis cyst volumes.Effective: clinical symptoms is alleviated to some extent, reduce 1/3 ~ 1/2 through ultrasound diagnosis cyst volumes.Invalid: clinical symptoms is without improvement, unchanged through ultrasound diagnosis cyst.
1.10 statistical analysis
Adopt SPSS14.0 statistical software, measurement data employing means standard deviation (
x±
s) represent, compare between group with one factor analysis of variance and
tinspection, enumeration data adopts
χ2 inspections.
2 results
2.1 Baseline Data
Include sample 100 example in and be inpatient in year January institute of traditional Chinese medicine's department of obstetrics and gynecology in January, 2013 to 2014, two groups of demographic data and Clinical symptoms have harmony (
p> 0.05), in Table 3-1.
Table 3-1 two groups of demographic data and Clinical symptoms (
n,
±
s)
2.2 exit case
Viewing duration is without exiting case.
2.3 come off case
Viewing duration is without the case that comes off.
2.4 clinical efficacy
Continuous treatment 3 course for the treatment of (90d), clinical efficacy treatment group be better than matched group (
p< 0.05), in table 2.
Table 3-2 two groups of therapeutic outcomes
2.5 hormonal readiness
Continuous treatment 3 course for the treatment of (90d), two groups of hormonal readinesses are all improved (
p< 0.05), treatment group improve be better than matched group (
p< 0.05), in Table 3-3.
Table 3-3 two groups treatment front and back hormonal readiness (
±
s)
2.6 diameter of tumor and hemodynamics
Continuous treatment 3 course for the treatment of (90d), two groups of diameter of tumor and hemodynamics are all improved (
p< 0.05), treatment group improve be better than matched group (
p< 0.05), in Table 3-4.
Diameter of tumor and hemodynamics before and after table 3-4 two groups treatment (
±
s)
2.7 untoward reaction
In observation process two groups all without serious adverse events.
3 discuss and conclusion
This research shows, medicine of the present invention can effectively improve patient's hormonal readiness, and reduce high coagulation, good results, cyst volumes all obviously reduces, and has no adverse reaction, and is worthy to be popularized.
experiment four: representative case clinical trial diagnosis and treatment are observed
test case 1:
Name: Zhang
Age: 47 years old
Medical history: hysteromyoma 5.4cm-5.3cm
Check data: on April 22nd, 2015
Treatment: patient uses medicine of the present invention (same under temporary called after " woman Shu Kang vaginal tablet ") treatment after color ultrasound examination, and each medication 1, the next day uses once, shares medicine 10.
Therapeutic outcome: daily inspection in May 26 in 2015, check result is muscular tumor 5.1-4.0, obviously reduces, patient main suit, discharges rotten meat during medication, and dirt is broken waits secretions.
test case 2:
Name: Lee so-and-so
Age: 51 years old
Medical history: chronic cervicitis (2 degree), cervical polyp, Cervix diseases.
Check data: on April 8th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after color ultrasound examination, each medication 1, the next day, uses once, shares medicine 10.
Therapeutic outcome: in color ultrasound examination on May 21st, 2015, check result is that cervix uteri is normal.
test case 3:
Name: Cui so-and-so
Age: 30 years old
Medical history: chronic cervicitis.
Check data: on April 20th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after color ultrasound examination, each medication 1, the next day, uses once, shares medicine 8.
Therapeutic outcome: in color ultrasound examination on May 21st, 2015, check result is that cervix uteri is normal.
test case 4:
Name: Lee so-and-so
Age: 45 years old
Medical history: cervical erosion 2 degree, cervix uteri multiple cyst, hysteromyoma multiple 1.5-2.0.
Check data: on April 7th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after color ultrasound examination, each medication 1, the next day, uses once, shares medicine 10.
Therapeutic outcome: in color ultrasound examination on May 21st, 2015, check result is that cervix uteri is normal, and hysteromyoma, cyst has no.
test case 5:
Name: Bai
Age: 38 years old
Medical history: chronic cervicitis
Check data: on April 6th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after color ultrasound examination, each medication 1, the next day, uses once, shares medicine 10.
Therapeutic outcome: in color ultrasound examination on June 8th, 2015, check result is that cervix uteri is normal.
test case 6:
Name: Lee
Age: 36 years old
Medical history: chronic cervicitis vaginitis.
Check data: on May 7th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after inspection color ultrasound, each medication 1, the next day, uses once, shares medicine 8.
Therapeutic outcome: in color ultrasound examination on May 25th, 2015, check result is that cervix uteri is normal.
test case 7:
Name: gold certain
Age: 35 years old
Medical history: cervical cyst, vaginitis.
Check data: on May 9th, 2015
Treatment: patient uses woman Shu Kang vaginal tablet to treat after inspection color ultrasound, each medication 1, the next day, uses once, shares medicine 10.
Therapeutic outcome: in color ultrasound examination on June 1st, 2015, check result is that cervix uteri is normal, and vaginitis is fully recovered.
detailed description of the invention:
Embodiment 1:
Drug prescription: dried Alumen 286g, Alumen 71.5g, Plumbum preparatium 114.4g, Borax(calcined) 143g, Olibanum 114.4g, Myrrha 114.4g, catechu 114.4g, Borneolum Syntheticum 28.6g, Indigo Naturalis 14.3g.
Preparation method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Function cures mainly: blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, and antiinflammatory is only rotten.Cure mainly dysmenorrhea, abnormal flavour, pruritus, various vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease, hysteromyoma, ovarian cyst, ovary polyps.
Embodiment 2:
Drug prescription: dried Alumen 169.2g, Alumen 169.2g, Plumbum preparatium 141g, Borax(calcined) 141g, Olibanum 122.2g, Myrrha 122.2g, catechu 94g, Borneolum Syntheticum 37.6g, Indigo Naturalis 9.4g
Preparation method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Function cures mainly: blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, and antiinflammatory is only rotten.Cure mainly dysmenorrhea, abnormal flavour, pruritus, various vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease, hysteromyoma, ovarian cyst, ovary polyps.
Embodiment 3:
Drug prescription: dried Alumen 172.5g, Alumen 172.5g, Plumbum preparatium 138g, Borax(calcined) 115g, Olibanum 115g, Myrrha 92g, catechu 115g, Borneolum Syntheticum 57.5g, Indigo Naturalis 23g
Preparation method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Function cures mainly: blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, and antiinflammatory is only rotten.Cure mainly dysmenorrhea, abnormal flavour, pruritus, various vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease, hysteromyoma, ovarian cyst, ovary polyps.
Embodiment 4:
Drug prescription: dried Alumen 286g, Alumen 71.5g, Plumbum preparatium 114.4g, Borax(calcined) 143g, Olibanum 114.4g, Myrrha 114.4g, catechu 114.4g, Borneolum Syntheticum 28.6g, Indigo Naturalis 14.3g
Preparation method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, is pressed into vaginal tablet 1000.
Function cures mainly: blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, and antiinflammatory is only rotten.Cure mainly dysmenorrhea, abnormal flavour, pruritus, various vaginitis, cervicitis, cervical erosion, pelvic inflammatory disease, hysteromyoma, ovarian cyst, ovary polyps.
As follows at the Ji Yuan of medicine Raw medicine of the present invention:
Dried Alumen, has another name called calcined Alumen, for Alumen heating is dissolved and is calcined to dried-up crystalline solid.
Alumen, having another name called Alumen, Alumen, snow vitriol, Muscovitum vitriol, raw vitriol, is Sulfates alunite mineral alunite
alunitethrough the crystallization that processing is refined.
Plumbum preparatium, has another name called Plumbum preparatium, Plumbum preparatium, Zhu Fen, Zhu Dan, Tao Dan, lead powder used in cosmetics, is the lead orthoplumbate be processed into pure lead.
Borax, has another name called large friend's sand, Borax, friend's sand, Borax, basin sand, is borate family Borax race mineral Borax
borax.Borax(calcined) is that fritter Borax puts heating in pot, and fry and lump to heaving the little snowy white that soaks, taking-up cools, and is ground into fine powder and is used as medicine.
Olibanum, has another name called nipple perfume (or spice), the perfume (or spice) that collapses, Ma Si answers Ji, pool, sky perfume, Moller are fragrant, Du Lu perfume, many gals Luo Xiang, bath perfume, are Burseraceae Boswellia Boswellia carterii
boswelliacarteriiBirdw., Bao Da Boswellia carterii
b.Bhaw-dajianaBirdw., wild Boswellia carterii B.neglectaM.Mooredeng the oleo-gum-resin that skin zone oozes out.
Myrrha, has another name called myrrh, is Burseraceae bdellium plant myrrh
commiphoramyrrhaEngl. [C.molmolEngl.]and the oleo-gum-resin that congener trunk skin zone oozes out.
Catechu, has another name called Catechu, black father girl, crow builds mud, Wu Dingni, powder catechu, CATECHU, gambier, is pulse family sallee catechu
acaciacatechu (L.f.) Willd.heartwood or the fried dry soft extracts of peeling branch.
Borneolum Syntheticum, has another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing, is Compositae Herba Blumeae Balsamiferae
blumeabalsamifera (L.) DC.stem and leaf or canella Borneolum Syntheticum Camphor tree
cinnamomumcamphora (L) preslbranch and leaf are through steam distillation and recrystallization and obtaining.
Indigo Naturalis, having another name called indigo flower, Concha Meretricis Seu Cyclinae powder, blue or green cylinder flower, indigo-blue flower, Lan Lu, shallow lake flower, indigo foam flower, is Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo
baphicacanthuscusia (Nees) Bremek. [GoldfussiacusiaNees; Strobilanthescusia (Nees) O.Kuntze], Polygonaceae arsesmart polygonum tinctorium ait.
polygonumtinctoriumAit., pulse family anil Folium et Caulis Indigoferae Tinctoriae
indigoferatinctoriaL., Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort.
isatisindigoticaFort.leaf or stem and leaf through processing obtained dried powder or agglomerate or granule.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (10)
1. the colpitic pharmaceutical composition for the treatment of, it is characterized in that, this pharmaceutical composition is made up of the raw material of following weight portion: dried Alumen 1 ~ 10 weight portion, Alumen 1 ~ 10 weight portion, Plumbum preparatium 1 ~ 20 weight portion, Borax(calcined) 1 ~ 20 weight portion, Olibanum 1 ~ 20 weight portion, Myrrha 1 ~ 20 weight portion, catechu 1 ~ 20 weight portion, Borneolum Syntheticum 1 ~ 20 weight portion, Indigo Naturalis 1 ~ 20 weight portion.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, this pharmaceutical composition is made up of the raw material of following weight portion: dried Alumen 18 weight portion, Alumen 18 weight portion, Plumbum preparatium 15 weight portion, Borax(calcined) 15 weight portion, Olibanum 13 weight portion, Myrrha 13 weight portion, catechu 10 weight portion, Borneolum Syntheticum 4 weight portion, Indigo Naturalis 1 weight portion.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, this pharmaceutical composition is made up of the raw material of following weight portion: dried Alumen 15 weight portion, Alumen 15 weight portion, Plumbum preparatium 12 weight portion, Borax(calcined) 10 weight portion, Olibanum 10 weight portion, Myrrha 8 weight portion, catechu 10 weight portion, Borneolum Syntheticum 5 weight portion, Indigo Naturalis 2 weight portion.
4. pharmaceutical composition as claimed in claim 1, it is characterized in that, this pharmaceutical composition is made up of the raw material of following weight portion: dried Alumen 20 weight portion, Alumen 5 weight portion, Plumbum preparatium 8 weight portion, Borax(calcined) 10 weight portion, Olibanum 8 weight portion, Myrrha 8 weight portion, catechu 8 weight portion, Borneolum Syntheticum 2 weight portion, Indigo Naturalis 1 weight portion.
5. the pharmaceutical composition as described in Claims 1 to 4 any one, is characterized in that, this pharmaceutical composition adopts pharmaceutical methods conventional in pharmacy to be prepared into vagina administration preparation.
6. pharmaceutical composition as claimed in claim 5, it is characterized in that, this pharmaceutical composition is adopted and is prepared with the following method: get dried Alumen, Alumen, Plumbum preparatium, Borax(calcined), Olibanum, Myrrha, catechu, Borneolum Syntheticum, Indigo Naturalis, mix homogeneously, be ground into fine powder, add adjuvant, mixing, be pressed into vaginal tablet, obtain final product.
7. the application of the pharmaceutical composition as described in Claims 1 to 4 any one in preparation treatment dysmenorrhea, abnormal flavour, pruritus medicine.
8. the application of the pharmaceutical composition as described in Claims 1 to 4 any one in preparation treatment pelvic inflammatory disease, cervicitis, cervical erosion medicine.
9. the application of the pharmaceutical composition as described in Claims 1 to 4 any one in preparation treatment hysteromyoma medicine.
10. the application of the pharmaceutical composition as described in Claims 1 to 4 any one in preparation treatment ovarian cyst, ovary polyps, ovarian cancer.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998129A (en) * | 2016-05-16 | 2016-10-12 | 杨洁 | Slough removing and tissue regeneration growth promoting medicine applied to gynecology and preparation method thereof |
| CN106389978A (en) * | 2016-05-16 | 2017-02-15 | 付国亮 | Medicine for treating fungal inflammations in gynecological department |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179971A (en) * | 1997-09-09 | 1998-04-29 | 张惠媛 | Traditional Chinese medicine for curing leukoplakia vulvae of gynecopathy |
| CN101264126A (en) * | 2007-03-14 | 2008-09-17 | 高振成 | Externally-applied medicine for treating gynecological inflammation and infertility caused by the same and preparation |
| CN101698018A (en) * | 2009-11-12 | 2010-04-28 | 何雪亚 | Traditional Chinese medicine composite for treating gynecologic diseases and preparation method thereof |
| CN102018805A (en) * | 2010-12-17 | 2011-04-20 | 张掖医学高等专科学校 | Drug for treating relapsable vulvovaginal candidiasis |
| CN102727634A (en) * | 2011-04-02 | 2012-10-17 | 于邈 | Traditional Chinese medicine composition for treating gynecological disease |
| CN103071093A (en) * | 2013-01-17 | 2013-05-01 | 遵义县南白镇华南药房 | Medicine for treating gynecological diseases |
-
2015
- 2015-08-12 CN CN201510491975.3A patent/CN105055493A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179971A (en) * | 1997-09-09 | 1998-04-29 | 张惠媛 | Traditional Chinese medicine for curing leukoplakia vulvae of gynecopathy |
| CN101264126A (en) * | 2007-03-14 | 2008-09-17 | 高振成 | Externally-applied medicine for treating gynecological inflammation and infertility caused by the same and preparation |
| CN101698018A (en) * | 2009-11-12 | 2010-04-28 | 何雪亚 | Traditional Chinese medicine composite for treating gynecologic diseases and preparation method thereof |
| CN102018805A (en) * | 2010-12-17 | 2011-04-20 | 张掖医学高等专科学校 | Drug for treating relapsable vulvovaginal candidiasis |
| CN102727634A (en) * | 2011-04-02 | 2012-10-17 | 于邈 | Traditional Chinese medicine composition for treating gynecological disease |
| CN103071093A (en) * | 2013-01-17 | 2013-05-01 | 遵义县南白镇华南药房 | Medicine for treating gynecological diseases |
Non-Patent Citations (1)
| Title |
|---|
| 杨晓晖等: "宫颈丸治疗874例宫颈糜烂疗效", 《中成药分析》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998129A (en) * | 2016-05-16 | 2016-10-12 | 杨洁 | Slough removing and tissue regeneration growth promoting medicine applied to gynecology and preparation method thereof |
| CN106389978A (en) * | 2016-05-16 | 2017-02-15 | 付国亮 | Medicine for treating fungal inflammations in gynecological department |
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