CN106376779A - Feed additive for treating vibrio diseases of large yellow croakers and preparation method of feed additive - Google Patents

Feed additive for treating vibrio diseases of large yellow croakers and preparation method of feed additive Download PDF

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CN106376779A
CN106376779A CN201610968600.6A CN201610968600A CN106376779A CN 106376779 A CN106376779 A CN 106376779A CN 201610968600 A CN201610968600 A CN 201610968600A CN 106376779 A CN106376779 A CN 106376779A
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parts
herba
radix
feed additive
rhizoma
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袁国防
李洪
孙明
王亮
宋辉
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Qingdao Haizhixing Biotechnology Co Ltd
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Qingdao Haizhixing Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K35/63—Arthropods
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract

The invention relates to a feed additive for treating vibrio diseases of large yellow croakers, and further relates to a preparation method of the feed additive. The feed additive provided by the invention is prepared from the following components in parts by mass: 21 to 27 parts of herba patriniae, 20 to 25 parts of herba corydalis bungeanae, 20 to 25 parts of folium mori, 19 to 26 parts of Chinese tamarisk twing, 18 to 25 parts of herba violae, 15 to 20 parts of succus bambusae, 15 to 20 parts of spica prunellae, 10 to 16 parts of cortex meliae, 16 to 21 parts of herba pteridis multifidae, 5 to 8 parts of squama manitis, 7 to 11 parts of ramulus cinnamomi, 7 to 12 parts of galla chinensis, 18 to 25 parts of flos puerariae, 9 to 12 parts of herb of mentha arvensis, 12 to 17 parts of leaf of banyan, 12 to 20 parts of flos hibisci rosae-sinensis, 14 to 20 parts of radix et caulis opuntiae dillenii, 7 to 10 parts of fructus amomi, 11 to 16 parts of rhizoma phragmitis, 8 to 11 parts of rhizoma bolbostemmae, 7 to 11 parts of folium photiniae and the like. The feed additive provided by the invention can be used for effectively treating the vibrio diseases of the large yellow croakers.

Description

A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis and preparation method thereof
Technical field
The invention belongs to technical field of aquaculture, more particularly, to a kind of feed additive treating Radix Et Rhizoma Rhei vibriosis； Further relate to a kind of preparation method of the feed additive of above-mentioned treatment Radix Et Rhizoma Rhei vibriosis.
Background technology
Carnis Pseudosciaenae belongs to Osteichthyess, Perciformess, Sciaenidae, Channa argus genus, also known as Channa argus, (big for traditional " four big marine products " One of Channa argus, Carnis Pseudosciaenae, Trichiurus haumela, sepiellae seu sepiae), it is China coastal seas Main Commercial Fishes.Carnis Pseudosciaenae, body extension, flat-sided, body is about 40-50cm, body is golden yellow, and caudal peduncle is elongated, and squama is less, has 8-9 row squama between dorsal fin starting point to side line；25-27 piece of vertebra.Carnis Pseudosciaenae Inhabit compared with abysmal area at ordinary times, the 4-6 month lays eggs to coastal waters migration, is dispersed in littoral forage after spawning, with fish and shrimp etc. for eating；Autumn and winter Season is again to abysmal area migration.Radix Et Rhizoma Rhei Air Bladder pseudosciaenae seu Acipenser energy sounding, fisherman often estimates the size of the shoal of fish whereby.Carnis Pseudosciaenae is distributed mainly on south Sea, the East Sea and southern Yellow Sea, for the important economic fish of China, are available for eating raw or dried yellow croaker processed etc.；Fish glue can glue.At present Realize artificial cultivation.
Vibriosises are seawater fish common diseases, during the cultivation of Carnis Pseudosciaenae juvenile fish, are easily endangered by vibriosises, Radix Et Rhizoma Rhei The cause of disease of vibriosis is mainly vibrio bacteria, and its cardinal symptom is：Sick fish with ulcer in body surface as principal character, head when serious Portion kiss end, body surface, fin ray bleeding are rotted, and internal organs lesions are obvious sometimes.This disease monthly has generation, and 7～August is occurred frequently Phase, up to more than 80% when mortality rate is high.The treatment meanss commonly used at present are big from norfloxacin, Ciprofloxacin, chloromycetin, celebrating The antibacterials such as mycin are admixed in bait, and consumption is the 1%～3% of daily ration, feeding quantity, continuously feeds 5～10 days.But antibiotic A large amount of use not only results in abuse of antibiotics, influence ecological environment, but also can finally affect the health of the mankind, is unfavorable for big The sustainable health development of Channa argus aquaculture.
Content of the invention
An object of the present invention is to provide a kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, and its raw material components is Green pure natural material, and can effectively treatment Radix Et Rhizoma Rhei vibriosis.
In order to solve above-mentioned technical problem, the present invention employs the following technical solutions, and a kind of treats raising of Radix Et Rhizoma Rhei vibriosis Feed additives, are prepared from by each component of following masses number：Herba Patriniae 21-27 part, Herba Corydalis Bungeanae 20-25 part, Folium Mori 20-25 Part, Cacumen Tamariciss 19-26 part, Herba Violae 18-25 part, Succus Bambusae 15-20 part, Spica Prunellae 15-20 part, Cortex Meliae 10-16 part, phoenix tail Careless 16-21 part, Squama Maniss 5-8 part, Ramulus Cinnamomi 7-11 part, Galla Chinensiss 7-12 part, Flos puerariae lobatae 18-25 part, wild mint 9-12 part, Folium fici microcarpae 12-17 part, Flos Hibisci Rosae-Sinensis 12-20 part, Radix et Caulis Opuntiae Dillenii 14-20 part, Fructus Amomi 7-10 part, Rhizoma Phragmitiss 11-16 part, Rhizoma Bolbostematiss 8-11 part, Chinese photinia Leaf 7-11 part, conch meal 2-3 part, Fructus Crataegi 2-3 part, Pericarpium Citri Reticulatae 1-2 part, red line worm 16-21 part, euphausia superba powder 18-25 part, fish flour 12-17 part, fish oil 1-2 part.
Preferably, the feed additive of described treatment Radix Et Rhizoma Rhei vibriosis, by each component preparation of following masses number Become：21 parts of Herba Patriniae, 22 parts of Herba Corydalis Bungeanae, 21 parts of Folium Mori, 24 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 15 parts of Succus Bambusae, Spica Prunellae 20 Part, 12 parts of Cortex Meliae, 16 parts of Herba Pteridis Multifidae, 6 parts of Squama Maniss, 9 parts of Ramulus Cinnamomi, 7 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 12 parts of wild mint, Ficus microcarpa Linn. f 12 parts of leaf, 15 parts of Flos Hibisci Rosae-Sinensis, 14 parts of Radix et Caulis Opuntiae Dillenii, 9 parts of Fructus Amomi, 11 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 11 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 16 parts of red line worm, 21 parts of euphausia superba powder, 17 parts of fish flour, 1 part of fish oil.
Preferably, the feed additive of described treatment Radix Et Rhizoma Rhei vibriosis, by each component preparation of following masses number Become：24 parts of Herba Patriniae, 24 parts of Herba Corydalis Bungeanae, 25 parts of Folium Mori, 20 parts of Cacumen Tamariciss, 18 parts of Herba Violae, 18 parts of Succus Bambusae, Spica Prunellae 16 Part, 10 parts of Cortex Meliae, 19 parts of Herba Pteridis Multifidae, 7 parts of Squama Maniss, 7 parts of Ramulus Cinnamomi, 10 parts of Galla Chinensiss, 21 parts of Flos puerariae lobatae, 9 parts of wild mint, Ficus microcarpa Linn. f 14 parts of leaf, 17 parts of Flos Hibisci Rosae-Sinensis, 15 parts of Radix et Caulis Opuntiae Dillenii, 10 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 11 parts of Rhizoma Bolbostematiss, 9 parts of Folium Photiniae (Folium Photiniae serrulatae), conch meal 2 Part, 2 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 19 parts of red line worm, 18 parts of euphausia superba powder, 15 parts of fish flour, 2 parts of fish oil.
Preferably, the feed additive of described treatment Radix Et Rhizoma Rhei vibriosis, by each component preparation of following masses number Become：25 parts of Herba Patriniae, 21 parts of Herba Corydalis Bungeanae, 22 parts of Folium Mori, 19 parts of Cacumen Tamariciss, 25 parts of Herba Violae, 16 parts of Succus Bambusae, Spica Prunellae 17 Part, 16 parts of Cortex Meliae, 21 parts of Herba Pteridis Multifidae, 5 parts of Squama Maniss, 10 parts of Ramulus Cinnamomi, 12 parts of Galla Chinensiss, 18 parts of Flos puerariae lobatae, 11 parts of wild mint, banyan 16 parts of leaveves, 12 parts of Flos Hibisci Rosae-Sinensis, 18 parts of Radix et Caulis Opuntiae Dillenii, 8 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 10 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), conch meal 3 Part, 2 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 21 parts of red line worm, 20 parts of euphausia superba powder, 12 parts of fish flour, 2 parts of fish oil.
Preferably, the feed additive of described treatment Radix Et Rhizoma Rhei vibriosis, by each component preparation of following masses number Become：26 parts of Herba Patriniae, 20 parts of Herba Corydalis Bungeanae, 24 parts of Folium Mori, 25 parts of Cacumen Tamariciss, 22 parts of Herba Violae, 20 parts of Succus Bambusae, Spica Prunellae 15 Part, 16 parts of Cortex Meliae, 20 parts of Herba Pteridis Multifidae, 8 parts of Squama Maniss, 9 parts of Ramulus Cinnamomi, 11 parts of Galla Chinensiss, 25 parts of Flos puerariae lobatae, 10 parts of wild mint, banyan 17 parts of leaveves, 18 parts of Flos Hibisci Rosae-Sinensis, 17 parts of Radix et Caulis Opuntiae Dillenii, 7 parts of Fructus Amomi, 15 parts of Rhizoma Phragmitiss, 8 parts of Rhizoma Bolbostematiss, 8 parts of Folium Photiniae (Folium Photiniae serrulatae), conch meal 2 Part, 3 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 17 parts of red line worm, 25 parts of euphausia superba powder, 16 parts of fish flour, 2 parts of fish oil.
Preferably, the feed additive of described treatment Radix Et Rhizoma Rhei vibriosis, by each component preparation of following masses number Become：27 parts of Herba Patriniae, 25 parts of Herba Corydalis Bungeanae, 20 parts of Folium Mori, 26 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 17 parts of Succus Bambusae, Spica Prunellae 18 Part, 15 parts of Cortex Meliae, 18 parts of Herba Pteridis Multifidae, 6 parts of Squama Maniss, 11 parts of Ramulus Cinnamomi, 9 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 11 parts of wild mint, banyan 15 parts of leaveves, 20 parts of Flos Hibisci Rosae-Sinensis, 20 parts of Radix et Caulis Opuntiae Dillenii, 9 parts of Fructus Amomi, 14 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), conch meal 3 Part, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 21 parts of red line worm, 21 parts of euphausia superba powder, 17 parts of fish flour, 1 part of fish oil.
Usage and dosage：The feed additive of every 1kg fish body daily 10-20mg present invention of weight, the first staggering amount doubles, and mixes and raises throwing Hello, continuous use is fully recovered up to sick fish.
In the present invention, Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae, Succus Bambusae, Spica Prunellae, Cortex Meliae, phoenix tail Grass, Squama Maniss, Ramulus Cinnamomi, Galla Chinensiss, Flos puerariae lobatae, wild mint, Folium fici microcarpae, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Fructus Amomi, Rhizoma Phragmitiss, Rhizoma Bolbostematiss, Chinese photinia Leaf, conch meal with the medicine that aforementioned proportion and preparation method are prepared from can give full play to each group divide between Synergistic make With there is significant bactericidal and bacteriostatic effect to the pathogen vibrio of Radix Et Rhizoma Rhei vibriosis, and being good for beneficial to the fast quick-recovery of Carnis Pseudosciaenae Health state.Fructus Crataegi and Pericarpium Citri Reticulatae do not only have bactericidal effect, and have the effect of spleen benefiting and stimulating the appetite, relieving dyspepsia, are conducive to big Channa argus active is ingested, and then promotes Carnis Pseudosciaenae to ingest more feedstuffs, and then enables the nutritional labeling in feedstuff to be Radix Et Rhizoma Rhei Fish preferably supplements the nutrients and muscle power, due to being added with the feed additive obtained by the present invention in feedstuff, therefore improves Radix Et Rhizoma Rhei After the digestion of fish, Carnis Pseudosciaenae also eats into the feed additive of the present invention, the feed additive of the present invention while ingesting Play it after entering in Carnis Pseudosciaenae body to act on accordingly, and then effectively kill and suppression vibrio, therefore to Radix Et Rhizoma Rhei vibriosis There is good prevention and treatment effect.Red line worm, euphausia superba powder, fish flour and fish oil delicious flavour, after aforementioned proportion mixing There is to Carnis Pseudosciaenae good attractant effect, the mouthfeel of feed additive can be improved, energy food calling Carnis Pseudosciaenae ingests and more adds The feedstuff of the feed additive of the present invention, and then so that the nutritional labeling in feedstuff is entered in Carnis Pseudosciaenae body and by Carnis Pseudosciaenae profit With also making the composition that the pathogen to Radix Et Rhizoma Rhei vibriosis in feed additive has notable bactericidal and bacteriostatic effect enter Radix Et Rhizoma Rhei Fish body is interior and plays its respective action.
It is a further object of the present invention to provide a kind of preparation method of the feed additive of above-mentioned treatment Radix Et Rhizoma Rhei vibriosis, It comprises the following steps：
(1) weigh Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae according to proportioning, grind, addition weight is Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, 1-1.1 times of the gross weight of Herba Violae of rice are wrong, add load weighted Succus Bambusae, Seal after mix homogeneously, soak at room temperature 4-5 hour, dry；
(2) weigh Spica Prunellae, Cortex Meliae, Herba Pteridis Multifidae, Squama Maniss, Ramulus Cinnamomi, Galla Chinensiss according to proportioning, grind, mix, Sealing, puts in ultra cold storage freezer and preserves 24 hours, takes out；
(3) use ultrasonic Treatment 30 minutes immediately after the product of step (2) gained being taken out, obtain mixture；To mixture Plant the clear water adding 15-18 times that weight is total weight of the mixture, after soak at room temperature 5-6 hour, boil 20-30 minute by slow fire, Cross 80 mesh sieves and obtain decoction liquor；
(4) weigh Flos puerariae lobatae, wild mint, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Rhizoma Phragmitiss, Folium fici microcarpae and Fructus Crataegi according to proportioning, grind and mix Even, obtain mixture of viscous form；
(5) weigh Fructus Amomi, Folium Photiniae (Folium Photiniae serrulatae), Rhizoma Bolbostematiss and conch meal according to proportioning, grind, mix, slow fire parch 10-15 Minute, dry；
(6) weigh Pericarpium Citri Reticulatae according to proportioning, add in Pericarpium Citri Reticulatae weight be 12 times of Pericarpium Citri Reticulatae weight boiled water, soak 5-6 After hour, filter, take soak；
(7) weigh red line worm, euphausia superba powder and fish flour according to proportioning, grind to 150 mesh, mix；
(8) weigh fish oil according to proportioning, and the mixture with step (1) gained, step (3) obtain decoction liquor, step (4) mixture of viscous form of gained, the parch thing of step (5) gained, the soak of step (6) gained, step (7) gained mixed Compound mix homogeneously, in pressure be -0.06～-0.08Mpa, temperature be 40～45 DEG C under the conditions of be concentrated into relative density be 45 DEG C When 1.18～1.21；
(9) concentrate of step (8) gained is dried and removes moisture until moisture is less than 5%, micropowder is broken to mean diameter Less than 50 μm, obtain object.
The preparation method of the present invention is simple, and preparation process will not bring pollution to environment.In preparation method, will The purpose that Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae grind is to make effective ingredient in above-mentioned each component more Easily leach, and more thoroughly fully react between being conducive to each group to divide.By Spica Prunellae, Cortex Meliae, Herba Pteridis Multifidae, Squama Maniss, osmanthus Branch, Galla Chinensiss put into -80 DEG C of effects preserving 24 hours in ultra cold storage freezer after grinding be so that cell is become fragile, and is conducive to making Effective ingredient in each component is preferably fried in subsequent step, is more beneficial for more thoroughly fully reacting between each group is divided. The each component ultrasonic Treatment effect of 30 minutes taken out from ultra cold storage freezer is more to be sufficiently mixed each component, makes each component More it is fully contacted and then more fully react；The effect soaking 5-6 hour is advantageous between each group is divided be combineding with each other or reacting, Boil by slow fire 20-30 minute effect be effective ingredient in more fully fried each component so as to abundant react, be conducive to playing Bactericidal effect to vibrio, and the stimulation of medicine can be improved, more leniently act on Carnis Pseudosciaenae, be conducive to Radix Et Rhizoma Rhei Fish quickly gets well.The purpose that Flos puerariae lobatae, wild mint, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Rhizoma Phragmitiss, Folium fici microcarpae and Fructus Crataegi are ground is to increase Contact area when its other components with the present invention is reacted, is conducive to that reacts fully to carry out.By Fructus Amomi, Folium Photiniae (Folium Photiniae serrulatae), Rhizoma Bolbostematis Mix with other components after mother and conch meal slow fire parch 10-15 minute, drug effect can be improved, be conducive to playing the sterilization to vibrio Bacteriostasis.Add red line worm in the present invention, euphausia superba powder, fish flour and fish oil can lure that Carnis Pseudosciaenae eats the raising of the present invention into Feed additives and with the addition of the present invention feed additive feedstuff, the not only certain nutrition of Carnis Pseudosciaenae supplement, and favorably Enter in Carnis Pseudosciaenae body in the feed additive making the present invention, accelerate the therapeutic efficiency of medicine, also improve the utilization of medicine Rate.The effect that Pericarpium Citri Reticulatae boiled water is soaked 5-6 hour is the effective ingredient fully leaching in Pericarpium Citri Reticulatae.The concentration step of the present invention Purpose is the effective ingredient preferably retaining in reactant.Fine effect is advantageous for the feed additive of the present invention and raises Material preferably mixes, and feeds and is easier in water body to be absorbed by Carnis Pseudosciaenae, and then plays its effect.
The component of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present invention is environmental protection raw material, nontoxic to environment Harmless, do not contain chemical drugss or antibiotic, after the edible Carnis Pseudosciaenae controlled better, do not interfere with the healthy of people, Er Qieben The feed additive of invention is good to the curative effect of Radix Et Rhizoma Rhei vibriosis.
Compared with prior art, the invention has the beneficial effects as follows：
(1) in the present invention, Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae, Succus Bambusae, Spica Prunellae, Cortex Meliae, phoenix Tail grass, Squama Maniss, Ramulus Cinnamomi, Galla Chinensiss, Flos puerariae lobatae, wild mint, Folium fici microcarpae, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Fructus Amomi, Rhizoma Phragmitiss, Rhizoma Bolbostematiss, stone Nanmu leaf, conch meal with the medicine that aforementioned proportion and preparation method are prepared from can give full play to each group divide between Synergistic make With there is significant bactericidal and bacteriostatic effect to the pathogen vibrio of Radix Et Rhizoma Rhei vibriosis, and being good for beneficial to the fast quick-recovery of Carnis Pseudosciaenae Health state.Fructus Crataegi and Pericarpium Citri Reticulatae do not only have bactericidal effect, and have the effect of spleen benefiting and stimulating the appetite, relieving dyspepsia, are conducive to big Channa argus active is ingested, and then promotes Carnis Pseudosciaenae to ingest more feedstuffs, and then enables the nutritional labeling in feedstuff to be Radix Et Rhizoma Rhei Fish preferably supplements the nutrients and muscle power, due to being added with the feed additive obtained by the present invention in feedstuff, therefore improves Radix Et Rhizoma Rhei After the digestion of fish, Carnis Pseudosciaenae also eats into the feed additive of the present invention, the feed additive of the present invention while ingesting Play it after entering in Carnis Pseudosciaenae body to act on accordingly, and then effectively kill and suppression vibrio, therefore to Radix Et Rhizoma Rhei vibriosis There is good prevention and treatment effect.Red line worm, euphausia superba powder, fish flour and fish oil delicious flavour, after aforementioned proportion mixing There is to Carnis Pseudosciaenae good attractant effect, the mouthfeel of feed additive can be improved, energy food calling Carnis Pseudosciaenae ingests and more adds The feedstuff of the feed additive of the present invention, and then so that the nutritional labeling in feedstuff is entered in Carnis Pseudosciaenae body and by Carnis Pseudosciaenae profit With also making the composition that the pathogen to Radix Et Rhizoma Rhei vibriosis in feed additive has notable bactericidal and bacteriostatic effect enter Radix Et Rhizoma Rhei Fish body is interior and plays its respective action.
(2) preparation method of the present invention is simple, and preparation process will not bring pollution to environment.Preparation method In, the purpose that Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae are ground is the effective one-tenth making in above-mentioned each component Point it is easier to leach, and more thoroughly fully react between being conducive to each group to divide.By Spica Prunellae, Cortex Meliae, Herba Pteridis Multifidae, Chuan Shan First, Ramulus Cinnamomi, Galla Chinensiss put into -80 DEG C of effects preserving 24 hours in ultra cold storage freezer after grinding be so that cell is become fragile, and has Beneficial to making the effective ingredient in each component preferably fried in subsequent step, be more beneficial for each group divide between more thoroughly fully Reaction.The each component ultrasonic Treatment effect of 30 minutes taken out from ultra cold storage freezer is more to be sufficiently mixed each component, makes Each component is more fully contacted and then more fully reacts；Soak 5-6 hour effect be advantageous between each group is divided be combineding with each other or Reaction, the effect boiling 20-30 minute by slow fire is effective ingredient in more fully fried each component so as to abundant react, favorably Act in playing the bactericidal to vibrio, and the stimulation of medicine can be improved, more leniently act on Carnis Pseudosciaenae, favorably Quickly get well in Carnis Pseudosciaenae.The purpose that Flos puerariae lobatae, wild mint, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Rhizoma Phragmitiss, Folium fici microcarpae and Fructus Crataegi are ground It is the contact area increasing when its other components with the present invention is reacted, be conducive to fully carrying out of reaction.By Fructus Amomi, Chinese photinia Mix with other components after leaf, Rhizoma Bolbostematiss and conch meal slow fire parch 10-15 minute, drug effect can be improved, be conducive to playing to arc The bactericidal effect of bacterium.Add red line worm, euphausia superba powder, fish flour and fish oil in the present invention and can lure that Carnis Pseudosciaenae eats this into The feed additive invented and the feedstuff of the feed additive that with the addition of the present invention, the not only certain nutrition of Carnis Pseudosciaenae supplement, And be conducive to making the feed additive of the present invention to enter in Carnis Pseudosciaenae body, accelerate the therapeutic efficiency of medicine, also improve medicine The utilization rate of thing.The effect that Pericarpium Citri Reticulatae boiled water is soaked 5-6 hour is the effective ingredient fully leaching in Pericarpium Citri Reticulatae.The present invention's is dense The purpose of contracting step is the effective ingredient preferably retaining in reactant.The feedstuff that fine effect is advantageous for the present invention adds Plus agent is preferably mixed with feedstuff, feed and be easier in water body to be absorbed by Carnis Pseudosciaenae, and then play its effect.
(3) component of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present invention is environmental protection raw material, to environment Nontoxic, do not contain chemical drugss or antibiotic, after the edible Carnis Pseudosciaenae controlled better, do not interfere with the healthy of people, and And the feed additive of the present invention is good to the curative effect of Radix Et Rhizoma Rhei vibriosis.
Specific embodiment
Below example facilitates a better understanding of the present invention, but does not limit the present invention.Experiment in following embodiments Method, if no special instructions, is conventional method.
Embodiment 1
A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, is prepared from by each component of following masses number：Herba Patriniae 21 parts of grass, 22 parts of Herba Corydalis Bungeanae, 21 parts of Folium Mori, 24 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 15 parts of Succus Bambusae, 20 parts of Spica Prunellae, Cortex Meliae 12 parts, 16 parts of Herba Pteridis Multifidae, 6 parts of Squama Maniss, 9 parts of Ramulus Cinnamomi, 7 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 12 parts of wild mint, 12 parts of Folium fici microcarpae, help 15 parts of Flos Mori, 14 parts of Radix et Caulis Opuntiae Dillenii, 9 parts of Fructus Amomi, 11 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 11 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 16 parts of red line worm, 21 parts of euphausia superba powder, 17 parts of fish flour, 1 part of fish oil.
The preparation method of the feed additive of above-mentioned treatment Radix Et Rhizoma Rhei vibriosis is as follows：
(1) weigh Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae according to proportioning, grind, addition weight is Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, 1-1.1 times of the gross weight of Herba Violae of rice are wrong, add load weighted Succus Bambusae, Seal after mix homogeneously, soak at room temperature 4-5 hour, dry；
(2) weigh Spica Prunellae, Cortex Meliae, Herba Pteridis Multifidae, Squama Maniss, Ramulus Cinnamomi, Galla Chinensiss according to proportioning, grind, mix, Sealing, puts in ultra cold storage freezer and preserves 24 hours, takes out；
(3) use ultrasonic Treatment 30 minutes immediately after the product of step (2) gained being taken out, obtain mixture；To mixture Plant the clear water adding 15-18 times that weight is total weight of the mixture, after soak at room temperature 5-6 hour, boil 20-30 minute by slow fire, Cross 80 mesh sieves and obtain decoction liquor；
(4) weigh Flos puerariae lobatae, wild mint, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Rhizoma Phragmitiss, Folium fici microcarpae and Fructus Crataegi according to proportioning, grind and mix Even, obtain mixture of viscous form；
(5) weigh Fructus Amomi, Folium Photiniae (Folium Photiniae serrulatae), Rhizoma Bolbostematiss and conch meal according to proportioning, grind, mix, slow fire parch 10-15 Minute, dry；
(6) weigh Pericarpium Citri Reticulatae according to proportioning, add in Pericarpium Citri Reticulatae weight be 12 times of Pericarpium Citri Reticulatae weight boiled water, soak 5-6 After hour, filter, take soak；
(7) weigh red line worm, euphausia superba powder and fish flour according to proportioning, grind to 150 mesh, mix；
(8) weigh fish oil according to proportioning, and the mixture with step (1) gained, step (3) obtain decoction liquor, step (4) mixture of viscous form of gained, the parch thing of step (5) gained, the soak of step (6) gained, step (7) gained mixed Compound mix homogeneously, in pressure be -0.06～-0.08Mpa, temperature be 40～45 DEG C under the conditions of be concentrated into relative density be 45 DEG C When 1.18～1.21；
(9) concentrate of step (8) gained is dried and removes moisture until moisture is less than 5%, micropowder is broken to mean diameter Less than 50 μm, obtain object.
Embodiment 2
A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, is prepared from by each component of following masses number：Herba Patriniae 24 parts of grass, 24 parts of Herba Corydalis Bungeanae, 25 parts of Folium Mori, 20 parts of Cacumen Tamariciss, 18 parts of Herba Violae, 18 parts of Succus Bambusae, 16 parts of Spica Prunellae, Cortex Meliae 10 parts, 19 parts of Herba Pteridis Multifidae, 7 parts of Squama Maniss, 7 parts of Ramulus Cinnamomi, 10 parts of Galla Chinensiss, 21 parts of Flos puerariae lobatae, 9 parts of wild mint, 14 parts of Folium fici microcarpae, help 17 parts of Flos Mori, 15 parts of Radix et Caulis Opuntiae Dillenii, 10 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 11 parts of Rhizoma Bolbostematiss, 9 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 2 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 19 parts of red line worm, 18 parts of euphausia superba powder, 15 parts of fish flour, 2 parts of fish oil.
The preparation method of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present embodiment is with embodiment 1.
Embodiment 3
A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, is prepared from by each component of following masses number：Herba Patriniae 25 parts of grass, 21 parts of Herba Corydalis Bungeanae, 22 parts of Folium Mori, 19 parts of Cacumen Tamariciss, 25 parts of Herba Violae, 16 parts of Succus Bambusae, 17 parts of Spica Prunellae, Cortex Meliae 16 parts, 21 parts of Herba Pteridis Multifidae, 5 parts of Squama Maniss, 10 parts of Ramulus Cinnamomi, 12 parts of Galla Chinensiss, 18 parts of Flos puerariae lobatae, 11 parts of wild mint, 16 parts of Folium fici microcarpae, 12 parts of Flos Hibisci Rosae-Sinensis, 18 parts of Radix et Caulis Opuntiae Dillenii, 8 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 10 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), 3 parts of conch meal, Fructus Crataegi 2 Part, 2 parts of Pericarpium Citri Reticulatae, 21 parts of red line worm, 20 parts of euphausia superba powder, 12 parts of fish flour, 2 parts of fish oil.
The preparation method of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present embodiment is with embodiment 1.
Embodiment 4
A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, is prepared from by each component of following masses number：Herba Patriniae 26 parts of grass, 20 parts of Herba Corydalis Bungeanae, 24 parts of Folium Mori, 25 parts of Cacumen Tamariciss, 22 parts of Herba Violae, 20 parts of Succus Bambusae, 15 parts of Spica Prunellae, Cortex Meliae 16 parts, 20 parts of Herba Pteridis Multifidae, 8 parts of Squama Maniss, 9 parts of Ramulus Cinnamomi, 11 parts of Galla Chinensiss, 25 parts of Flos puerariae lobatae, 10 parts of wild mint, 17 parts of Folium fici microcarpae, 18 parts of Flos Hibisci Rosae-Sinensis, 17 parts of Radix et Caulis Opuntiae Dillenii, 7 parts of Fructus Amomi, 15 parts of Rhizoma Phragmitiss, 8 parts of Rhizoma Bolbostematiss, 8 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 3 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 17 parts of red line worm, 25 parts of euphausia superba powder, 16 parts of fish flour, 2 parts of fish oil.
The preparation method of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present embodiment is with embodiment 1.
Embodiment 5
A kind of feed additive treating Radix Et Rhizoma Rhei vibriosis, is prepared from by each component of following masses number：Herba Patriniae 27 parts of grass, 25 parts of Herba Corydalis Bungeanae, 20 parts of Folium Mori, 26 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 17 parts of Succus Bambusae, 18 parts of Spica Prunellae, Cortex Meliae 15 parts, 18 parts of Herba Pteridis Multifidae, 6 parts of Squama Maniss, 11 parts of Ramulus Cinnamomi, 9 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 11 parts of wild mint, 15 parts of Folium fici microcarpae, 20 parts of Flos Hibisci Rosae-Sinensis, 20 parts of Radix et Caulis Opuntiae Dillenii, 9 parts of Fructus Amomi, 14 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), 3 parts of conch meal, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 21 parts of red line worm, 21 parts of euphausia superba powder, 17 parts of fish flour, 1 part of fish oil.
The preparation method of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis of the present embodiment is with embodiment 1.
Experimental result
Contrast experiment 1
Test fish is divided into 6 groups, every group two parallel, respectively matched group, test A group, test B group, test C group, examination Test D group, test E group, every group of process is as follows：
The process of matched group is as follows：Add norfloxacin in feedstuff, the consumption of norfloxacin is the 2% of daily ration, feeding quantity, first day Double, continuously using until fully recovering.
The process of experiment A group is as follows：The feed additive of every daily 15mg embodiment of the present invention 1 of 1kg fish body weight, first day Double, mix to raise and feed, continuous using until sick fish recovery from illness.
The process of experiment B group is as follows：The feed additive of every daily 15mg embodiment of the present invention 2 of 1kg fish body weight, first day Double, mix to raise and feed, continuous using until sick fish recovery from illness.
The process of experiment C group is as follows：The feed additive of every daily 15mg embodiment of the present invention 3 of 1kg fish body weight, first day Double, mix to raise and feed, continuous using until sick fish recovery from illness.
The process of experiment D group is as follows：The feed additive of every daily 15mg embodiment of the present invention 4 of 1kg fish body weight, first day Double, mix to raise and feed, continuous using until sick fish recovery from illness.
The process of experiment E group is as follows：The feed additive of every daily 15mg embodiment of the present invention 5 of 1kg fish body weight, first day Double, mix to raise and feed, continuous using until sick fish recovery from illness.
From the beginning of the 3rd day, fish for 10 Carnis Pseudosciaenae respectively from matched group net cage and experimental group net cage daily, check it Cure, and record, result of the test is shown in Table 1.
Wherein, the standard of sick fish recovery from illness is：The ulcer of sick fish body table disappears, and all no bleedings of head kiss end, body surface, fin ray are rotten Rotten phenomenon.
The feed additive therapeutic effect of the treatment Radix Et Rhizoma Rhei vibriosis of table 1 present invention
To sum up, test result indicate that：The feed additive of the treatment Radix Et Rhizoma Rhei vibriosis of the present invention is to Radix Et Rhizoma Rhei vibriosis Cure rate high.
The above be only the preferred embodiment of the present invention it should be pointed out that：Ordinary skill people for the art For member, under the premise without departing from the principles of the invention, some improvement can also be made, these improvement should be regarded as the guarantor of the present invention Shield scope.

Claims (7)

1. a kind of feed additive treating Radix Et Rhizoma Rhei vibriosis it is characterised in that：Each component preparation by following masses number Form：Herba Patriniae 21-27 part, Herba Corydalis Bungeanae 20-25 part, Folium Mori 20-25 part, Cacumen Tamariciss 19-26 part, Herba Violae 18-25 part, bamboo Drip 15-20 part, Spica Prunellae 15-20 part, Cortex Meliae 10-16 part, Herba Pteridis Multifidae 16-21 part, Squama Maniss 5-8 part, Ramulus Cinnamomi 7-11 part, five Gall nut 7-12 part, Flos puerariae lobatae 18-25 part, wild mint 9-12 part, Folium fici microcarpae 12-17 part, Flos Hibisci Rosae-Sinensis 12-20 part, Radix et Caulis Opuntiae Dillenii 14-20 Part, Fructus Amomi 7-10 part, Rhizoma Phragmitiss 11-16 part, Rhizoma Bolbostematiss 8-11 part, Folium Photiniae (Folium Photiniae serrulatae) 7-11 part, conch meal 2-3 part, Fructus Crataegi 2-3 part, old Skin 1-2 part, red line worm 16-21 part, euphausia superba powder 18-25 part, fish flour 12-17 part, fish oil 1-2 part.
2. according to claim 1 treatment Radix Et Rhizoma Rhei vibriosis feed additive it is characterised in that：Described treatment Radix Et Rhizoma Rhei The feed additive of vibriosis, is prepared from by each component of following masses number：21 parts of Herba Patriniae, 22 parts of Herba Corydalis Bungeanae, Mulberry 21 parts of leaf, 24 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 15 parts of Succus Bambusae, 20 parts of Spica Prunellae, 12 parts of Cortex Meliae, 16 parts of Herba Pteridis Multifidae, wear mountain 6 parts of first, 9 parts of Ramulus Cinnamomi, 7 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 12 parts of wild mint, 12 parts of Folium fici microcarpae, 15 parts of Flos Hibisci Rosae-Sinensis, 14 parts of Radix et Caulis Opuntiae Dillenii, 9 parts of Fructus Amomi, 11 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 11 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 16 parts of red line worm, south 21 parts of pole krill meal, 17 parts of fish flour, 1 part of fish oil.
3. according to claim 1 treatment Radix Et Rhizoma Rhei vibriosis feed additive it is characterised in that：Described treatment Radix Et Rhizoma Rhei The feed additive of vibriosis, is prepared from by each component of following masses number：24 parts of Herba Patriniae, 24 parts of Herba Corydalis Bungeanae, Mulberry 25 parts of leaf, 20 parts of Cacumen Tamariciss, 18 parts of Herba Violae, 18 parts of Succus Bambusae, 16 parts of Spica Prunellae, 10 parts of Cortex Meliae, 19 parts of Herba Pteridis Multifidae, wear mountain 7 parts of first, 7 parts of Ramulus Cinnamomi, 10 parts of Galla Chinensiss, 21 parts of Flos puerariae lobatae, 9 parts of wild mint, 14 parts of Folium fici microcarpae, 17 parts of Flos Hibisci Rosae-Sinensis, 15 parts of Radix et Caulis Opuntiae Dillenii, 10 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 11 parts of Rhizoma Bolbostematiss, 9 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 2 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 19 parts of red line worm, 18 parts of euphausia superba powder, 15 parts of fish flour, 2 parts of fish oil.
4. according to claim 1 treatment Radix Et Rhizoma Rhei vibriosis feed additive it is characterised in that：Described treatment Radix Et Rhizoma Rhei The feed additive of vibriosis, is prepared from by each component of following masses number：25 parts of Herba Patriniae, 21 parts of Herba Corydalis Bungeanae, Mulberry 22 parts of leaf, 19 parts of Cacumen Tamariciss, 25 parts of Herba Violae, 16 parts of Succus Bambusae, 17 parts of Spica Prunellae, 16 parts of Cortex Meliae, 21 parts of Herba Pteridis Multifidae, wear mountain 5 parts of first, 10 parts of Ramulus Cinnamomi, 12 parts of Galla Chinensiss, 18 parts of Flos puerariae lobatae, 11 parts of wild mint, 16 parts of Folium fici microcarpae, 12 parts of Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii 18 Part, 8 parts of Fructus Amomi, 16 parts of Rhizoma Phragmitiss, 10 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), 3 parts of conch meal, 2 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, red line worm 21 Part, 20 parts of euphausia superba powder, 12 parts of fish flour, 2 parts of fish oil.
5. according to claim 1 treatment Radix Et Rhizoma Rhei vibriosis feed additive it is characterised in that：Described treatment Radix Et Rhizoma Rhei The feed additive of vibriosis, is prepared from by each component of following masses number：26 parts of Herba Patriniae, 20 parts of Herba Corydalis Bungeanae, Mulberry 24 parts of leaf, 25 parts of Cacumen Tamariciss, 22 parts of Herba Violae, 20 parts of Succus Bambusae, 15 parts of Spica Prunellae, 16 parts of Cortex Meliae, 20 parts of Herba Pteridis Multifidae, wear mountain 8 parts of first, 9 parts of Ramulus Cinnamomi, 11 parts of Galla Chinensiss, 25 parts of Flos puerariae lobatae, 10 parts of wild mint, 17 parts of Folium fici microcarpae, 18 parts of Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii 17 Part, 7 parts of Fructus Amomi, 15 parts of Rhizoma Phragmitiss, 8 parts of Rhizoma Bolbostematiss, 8 parts of Folium Photiniae (Folium Photiniae serrulatae), 2 parts of conch meal, 3 parts of Fructus Crataegi, 2 parts of Pericarpium Citri Reticulatae, 17 parts of red line worm, 25 parts of euphausia superba powder, 16 parts of fish flour, 2 parts of fish oil.
6. according to claim 1 treatment Radix Et Rhizoma Rhei vibriosis feed additive it is characterised in that：Described treatment Radix Et Rhizoma Rhei The feed additive of vibriosis, is prepared from by each component of following masses number：27 parts of Herba Patriniae, 25 parts of Herba Corydalis Bungeanae, Mulberry 20 parts of leaf, 26 parts of Cacumen Tamariciss, 20 parts of Herba Violae, 17 parts of Succus Bambusae, 18 parts of Spica Prunellae, 15 parts of Cortex Meliae, 18 parts of Herba Pteridis Multifidae, wear mountain 6 parts of first, 11 parts of Ramulus Cinnamomi, 9 parts of Galla Chinensiss, 22 parts of Flos puerariae lobatae, 11 parts of wild mint, 15 parts of Folium fici microcarpae, 20 parts of Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii 20 Part, 9 parts of Fructus Amomi, 14 parts of Rhizoma Phragmitiss, 9 parts of Rhizoma Bolbostematiss, 7 parts of Folium Photiniae (Folium Photiniae serrulatae), 3 parts of conch meal, 3 parts of Fructus Crataegi, 1 part of Pericarpium Citri Reticulatae, 21 parts of red line worm, 21 parts of euphausia superba powder, 17 parts of fish flour, 1 part of fish oil.
7. the preparation method of the feed additive for the treatment of Radix Et Rhizoma Rhei vibriosis any one of a kind of claim 1-6, its It is characterised by：Comprise the following steps：
(1) weigh Herba Patriniae, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, Herba Violae according to proportioning, grind, addition weight is Herba Patriniae Grass, Herba Corydalis Bungeanae, Folium Mori, Cacumen Tamariciss, 1-1.1 times of the gross weight of Herba Violae of rice are wrong, add load weighted Succus Bambusae, mixing Uniformly seal afterwards, soak at room temperature 4-5 hour, dry；
(2) weigh Spica Prunellae, Cortex Meliae, Herba Pteridis Multifidae, Squama Maniss, Ramulus Cinnamomi, Galla Chinensiss according to proportioning, grind, mix, close Envelope, puts in ultra cold storage freezer and preserves 24 hours, takes out；
(3) use ultrasonic Treatment 30 minutes immediately after the product of step (2) gained being taken out, obtain mixture；Add to mixing species Enter the clear water of 15-18 times that weight is total weight of the mixture, after soak at room temperature 5-6 hour, boil 20-30 minute by slow fire, cross 80 Mesh sieve obtains decoction liquor；
(4) weigh Flos puerariae lobatae, wild mint, Flos Hibisci Rosae-Sinensis, Radix et Caulis Opuntiae Dillenii, Rhizoma Phragmitiss, Folium fici microcarpae and Fructus Crataegi according to proportioning, grind and mix, obtain Mixture of viscous form；
(5) weigh Fructus Amomi, Folium Photiniae (Folium Photiniae serrulatae), Rhizoma Bolbostematiss and conch meal according to proportioning, grind, mix, slow fire parch 10-15 divides Clock, dries；
(6) weigh Pericarpium Citri Reticulatae according to proportioning, add in Pericarpium Citri Reticulatae weight be 12 times of Pericarpium Citri Reticulatae weight boiled water, soak 5-6 hour Afterwards, filter, take soak；
(7) weigh red line worm, euphausia superba powder and fish flour according to proportioning, grind to 150 mesh, mix；
(8) weigh fish oil according to proportioning, and the mixture with step (1) gained, step (3) obtain decoction liquor, step (4) institute Mixture of viscous form, the parch thing of step (5) gained, the soak of step (6) gained, the mixture of step (7) gained Mix homogeneously, in pressure be -0.06～-0.08Mpa, temperature be 40～45 DEG C under the conditions of be concentrated into relative density be 45 DEG C when 1.18～1.21；
(9) concentrate of step (8) gained is dried and removes moisture until moisture is less than 5%, micropowder is broken to 50 μm of mean diameter Hereinafter, obtain object.
CN201610968600.6A 2016-10-28 2016-10-28 Feed additive for treating vibrio diseases of large yellow croakers and preparation method of feed additive Withdrawn CN106376779A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102972659A (en) * 2012-12-13 2013-03-20 浙江海洋学院 Feed additive for large yellow croaker
CN106036205A (en) * 2016-05-30 2016-10-26 青岛海之源智能技术有限公司 Feed additive capable of treating streptococcal disease of tilapia and preparation method of feed additive

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102972659A (en) * 2012-12-13 2013-03-20 浙江海洋学院 Feed additive for large yellow croaker
CN106036205A (en) * 2016-05-30 2016-10-26 青岛海之源智能技术有限公司 Feed additive capable of treating streptococcal disease of tilapia and preparation method of feed additive

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