CN106362142A - Formula composition capable of reducing blood pressure - Google Patents
Formula composition capable of reducing blood pressure Download PDFInfo
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- CN106362142A CN106362142A CN201610956299.7A CN201610956299A CN106362142A CN 106362142 A CN106362142 A CN 106362142A CN 201610956299 A CN201610956299 A CN 201610956299A CN 106362142 A CN106362142 A CN 106362142A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention discloses a formula composition capable of reducing blood pressure and a preparation method thereof which relates to the technical field of pharmacy. The formula composition capable of reducing the blood pressure is prepared from the following components in parts by weight: 20 parts of male flower of eucommia ulmoides, 35 parts of pheretima protein powder, 20 parts of chrysanthemum morifolium flower, 20 parts of radix puerariae lobatae, 20 parts of folium ilicis latifoliae, 20 parts of radix arctii, 20 parts of semen cassiae, 20 parts of flos sophorae immaturus, 15 parts of fructus lycii, 20 parts of fructus crataegi, 20 parts of folium ginkgo, 20 parts of semen coicis, 30 parts of tartary buckwheat, 10 parts of celery seeds, 10 parts of corn stigma and an appropriate amount of nattokinase extract. The formula composition disclosed by the invention can be prepared into tablets, pills, granules or capsules according to a conventional method after being prepared according to the components, has the advantages of good effect, convenience in taking and convenience in carrying, is capable of avoiding a situation of curing the symptoms but not the disease and cannot damage other positions of a body.
Description
Technical field
The present invention relates to pharmaceutical technology field, specially a kind of formula combination that can reduce blood pressure.
Background technology
Hypertension (hypertension) refers to increase as main with systemic arterial blood pressure (systolic pressure and/or diastolic pressure)
The long-term chronic disease of feature (systolic pressure >=140 millimetres of mercury, diastolic pressure >=90 millimetres of mercury).Hypertension does not have under normal circumstances
There is obvious disease, but long-term hypertension is coronary artery hardening heart disease, apoplexy, heart failure, peripheral vascular disease,
Visual loss and the Major Risk Factors of chronic nephropathy.Hypertension is mainly caused by bad life style and inherited genetic factorss.Raw
Mode factor of living includes the picked-up of excessive salt, fat, smoking and heavy drinking etc..Because hypertension is not because of antibacterial and virus
Cause, using expanding blood vessel and diuresis principle more than traditional Western medicine, be to be produced afterwards by various stimulations (vascular stimulation, nerve stimulation)
's.Thus while final result sees the blood pressure drops of human body, but the result of this blood pressure drops is just to break human body
Premised on normal physiological law, and the blood pressure regulating mechanisms of human body itself do not obtain really effectively repairing.Motherland cures
Think that hypertension is due to deficiency of the kidney, deficiency of kidney yin and caused by leading to excessive rising of liver-YANG, therefore need YIN nourishing nourishing the liver, nourishing YIN and supplementing the kidney
Thus suppressing the hyperactive liver and subsiding YANG treatment hypertension.It is exactly to reach raising intracellular protease and people by trophocyte from the angle of doctor trained in Western medicine
The activity of body self immune system is treating chronic disease.With the change of the quickening of China human mortality aging, life style, high blood
Pressure patient morbidity be continuously increased, and because hypertension is again particularly serious to the harm of people, this disease is subject to various circles of society extensive
Pay attention to.
Content of the invention
It is an object of the invention to provide a kind of formula combination that can reduce blood pressure, to solve to carry in above-mentioned background technology
Go out due to hypertension be not because antibacterial and virus cause, using expanding blood vessel and diuresis principle more than traditional Western medicine, be by various
After stimulation produce, thus while final result sees the blood pressure drops of human body, but the result of this blood pressure drops be with
Premised on breaking the physiological law of human normal, and the blood pressure regulating mechanisms of human body itself do not obtain really effectively repairing
Multiple problem.
For achieving the above object, the present invention provides following technical scheme: a kind of formula combination that can reduce blood pressure, this can
With the formula combination that reduces blood pressure according to weight proportion: 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, Radix Puerariae
20 parts, 20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, the heart of a lotus seed
20 parts of Semen Coicis, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis, nattokinase extract is appropriate.
Preferably, described nattokinase extract makes for traditional zymotic technique Semen Sojae Preparatum, natto, sky shellfish lyophilized powder and
Rely on the gene prod nattokinase possessing high bioactivity of culture medium strain fermentation manufacture, be mainly used in dissolving endovascular
Thrombosis.
Preferably, the daily addition of described nattokinase is that 50-100mg activity is 4000fu/g or daily addition is
100-200mg activity is 2000fu/g.
Preferably, a kind of preparation method of the formula combination that can reduce blood pressure, a kind of this formula that can reduce blood pressure
The concretely comprising the following steps of preparation method of combination:
S1: stirring mixing, filter stock: by 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, Radix Puerariae 20
Part, 20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, Semen Coicis
20 parts of core, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis are placed in clean beaker, add appropriate water to enter in beaker
Row heated and stirred, mixed raw material filtration treatment the pasty state raw material after retaining drainage；
S2: raw material centrifugal treating: the pasty state raw material after filtering in step s1 is obtained, and pasty state raw material is placed in centrifugation
Carry out centrifugal treating in hydrophone, and supernatant is removed；
S3: raw material drying sterilization treatment: the raw material after centrifugation is placed in culture dish, by the culture with raw material after centrifugation
Ware is placed in heating furnace, is dried sterilization treatment using dry heat sterilization to the raw material after centrifugation；
S4: pressing mold pelletization treatment: shape is placed in corresponding mould as needed by the raw material after dry sterilization in step s3,
Carry out drying and processing by being placed in drying chamber after mould lid, after drying, add the product required for nattokinase extract is obtained in right amount
Product；
S5: packaging chilling treatment: the product packaging being obtained in step s4 is placed in cold room cold preservation, temperature of refrigerating chamber is
0-4 degree Celsius.
Preferably, add water in described step s1 and just do not had raw material, heating adopts heating in water bath, and heating-up temperature is
60-80 degree Celsius.
Preferably, on described step s3 culture dish, the thickness of raw material is 6-8 millimeter.
Preferably, in described step s3, the temperature of sterilizing is 120-140 degree Celsius, and sterilization time is 2-4 hour.
Preferably, the product in described step s4 can be changed being combined in proportion to the size of mould according to required
Medicament make tablet, pill, granule or capsule.
Compared with prior art, the invention has the beneficial effects as follows: after medicine of the present invention configures according to component, can be according to
Conventional method makes tablet, pill, granule or capsule, and it is good to have an effect, taking convenience, portable advantage, it is to avoid
Situation about curing the symptoms, not the disease, will not be to damage body elsewhere.
Brief description
Fig. 1 is workflow diagram of the present invention；
Fig. 2 is medical survey average response figure of the present invention.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Site preparation description is it is clear that described embodiment is only a part of embodiment of the present invention, rather than whole embodiments.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of not making creative work
Embodiment, broadly falls into the scope of protection of the invention.
Refer to Fig. 1, the present invention provides a kind of technical scheme: a kind of formula combination that can reduce blood pressure, this can drop
Hypotensive formula combination is according to weight proportion: 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, 20 parts of Radix Puerariae,
20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, SEMEN COICIS 20
Part, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis, nattokinase extract is appropriate, and described nattokinase extract is to pass
The high biology that possesses of Semen Sojae Preparatum, natto, sky shellfish lyophilized powder and dependence culture medium strain fermentation manufacture that system fermentation technology makes is lived
Property gene prod nattokinase, the daily addition of described nattokinase is that 50-100mg activity adds for 4000fu/g or daily
Dosage is 100-200mg activity is 2000fu/g.
Embodiment one
A kind of preparation method of the formula combination that can reduce blood pressure it is characterised in that: this is a kind of can to reduce blood pressure
The concretely comprising the following steps of the preparation method of formula combination:
S1: stirring mixing, filter stock: by 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, Radix Puerariae 20
Part, 20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, Semen Coicis
20 parts of core, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis, nattokinase extract is placed in clean beaker in right amount and is placed in
In clean beaker, appropriate water is added to carry out heated and stirred in beaker, mixed raw material filtration treatment after retaining drainage
Pasty state raw material, add water to and just do not had raw material, heating adopt heating in water bath, heating-up temperature be 60 degrees Celsius；
S2: raw material centrifugal treating: the pasty state raw material after filtering in step s1 is obtained, and pasty state raw material is placed in centrifugation
Carry out centrifugal treating in hydrophone, and supernatant is removed；
S3: raw material drying sterilization treatment: the raw material after centrifugation is placed in culture dish, by the culture with raw material after centrifugation
Ware is placed in heating furnace, is dried sterilization treatment using dry heat sterilization to the raw material after centrifugation, the thickness of raw material on culture dish
For 6 millimeters, the temperature of sterilizing is 120 degrees Celsius, and sterilization time is 2 hours；
S4: pressing mold pelletization treatment: shape is placed in corresponding mould as needed by the raw material after dry sterilization in step s3,
Carry out drying and processing by being placed in drying chamber after mould lid, after drying, add the product required for nattokinase extract is obtained in right amount
Product, according to required the size of mould can be changed by the medicament combining in proportion make tablet, pill, granule or
Capsule；
S5: packaging chilling treatment: the product packaging being obtained in step s4 is placed in cold room cold preservation, temperature of refrigerating chamber is
0 degree Celsius.
Embodiment two
A kind of preparation method of the formula combination that can reduce blood pressure it is characterised in that: this is a kind of can to reduce blood pressure
The concretely comprising the following steps of the preparation method of formula combination:
S1: stirring mixing, filter stock: by 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, Radix Puerariae 20
Part, 20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, Semen Coicis
20 parts of core, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis, nattokinase extract is placed in clean beaker in right amount and is placed in
In clean beaker, appropriate water is added to carry out heated and stirred in beaker, mixed raw material filtration treatment after retaining drainage
Pasty state raw material, add water to and just do not had raw material, heating adopt heating in water bath, heating-up temperature be 70 degrees Celsius；
S2: raw material centrifugal treating: the pasty state raw material after filtering in step s1 is obtained, and pasty state raw material is placed in centrifugation
Carry out centrifugal treating in hydrophone, and supernatant is removed；
S3: raw material drying sterilization treatment: the raw material after centrifugation is placed in culture dish, by the culture with raw material after centrifugation
Ware is placed in heating furnace, is dried sterilization treatment using dry heat sterilization to the raw material after centrifugation, the thickness of raw material on culture dish
For 7 millimeters, the temperature of sterilizing is 130 degrees Celsius, and sterilization time is 3 hours；
S4: pressing mold pelletization treatment: shape is placed in corresponding mould as needed by the raw material after dry sterilization in step s3,
Carry out drying and processing by being placed in drying chamber after mould lid, after drying, add the product required for nattokinase extract is obtained in right amount
Product, according to required the size of mould can be changed by the medicament combining in proportion make tablet, pill, granule or
Capsule；
S5: packaging chilling treatment: the product packaging being obtained in step s4 is placed in cold room cold preservation, temperature of refrigerating chamber is
2 degrees Celsius.
Embodiment three
A kind of preparation method of the formula combination that can reduce blood pressure it is characterised in that: this is a kind of can to reduce blood pressure
The concretely comprising the following steps of the preparation method of formula combination:
S1: stirring mixing, filter stock: by 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, Radix Puerariae 20
Part, 20 parts of Folium Ilicis, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, Semen Coicis
20 parts of core, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis, nattokinase extract is placed in clean beaker in right amount and is placed in
In clean beaker, appropriate water is added to carry out heated and stirred in beaker, mixed raw material filtration treatment after retaining drainage
Pasty state raw material, add water to and just do not had raw material, heating adopt heating in water bath, heating-up temperature be 80 degrees Celsius；
S2: raw material centrifugal treating: the pasty state raw material after filtering in step s1 is obtained, and pasty state raw material is placed in centrifugation
Carry out centrifugal treating in hydrophone, and supernatant is removed；
S3: raw material drying sterilization treatment: the raw material after centrifugation is placed in culture dish, by the culture with raw material after centrifugation
Ware is placed in heating furnace, is dried sterilization treatment using dry heat sterilization to the raw material after centrifugation, the thickness of raw material on culture dish
For 8 millimeters, the temperature of sterilizing is 140 degrees Celsius, and sterilization time is 4 hours；
S4: pressing mold pelletization treatment: shape is placed in corresponding mould as needed by the raw material after dry sterilization in step s3,
Carry out drying and processing by being placed in drying chamber after mould lid, after drying, add the product required for nattokinase extract is obtained in right amount
Product, according to required the size of mould can be changed by the medicament combining in proportion make tablet, pill, granule or
Capsule；
S5: packaging chilling treatment: the product packaging being obtained in step s4 is placed in cold room cold preservation, temperature of refrigerating chamber is
4 degrees Celsius.
According to the experimental result of three above embodiment, we show that optimum implementation is embodiment two.
Clinical trial
Case one: poplar, man, 60 years old, high pressure was in 160 about, three years hypertension history.Take pill of the present invention, one day 3
Secondary, 30 days is a course for the treatment of, and after after one month, high pressure is down to 140,3 courses for the treatment of, blood pressure recovered to normal range, consolidates 2 afterwards again
The individual course for the treatment of, blood pressure is normal on inspection.
Case two: Liu, female, 58,1 years hypertension history, vertigo symptoms occurred in 2015, blood pressure reaches 170 about.Clothes
Use pill of the present invention, 3 times a day, 30 days is a course for the treatment of, and after a course for the treatment of, blood pressure is down to 140, and vertigo symptoms mitigate, and continues
After taking 3 courses for the treatment of, blood pressure recovers to 120.
Case three: poplar, female, 57 years old, there is 8 years hypertension history, blood pressure range is up to 220, with dizziness.Take
Product of the present invention, one day three doses, 3 times a day, 30 days be a course for the treatment of, after a course for the treatment of, blood pressure is down to 125.
Refer to Fig. 2, through clinical practice, general patient's present invention was taken effect using 10 days about, dizziness after treatment
It is obviously improved.A day three times, 30 days is 1 course for the treatment of, can have positive effect using the 2-6 course for the treatment of.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, permissible
Understand and can carry out multiple changes, modification, replacement to these embodiments without departing from the principles and spirit of the present invention
And modification, the scope of the present invention be defined by the appended.
Claims (8)
1. a kind of formula combination that can reduce blood pressure it is characterised in that: the formula combination that this can reduce blood pressure is according to weight
Proportioning includes: 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, 20 parts of Radix Puerariae, 20 parts of Folium Ilicis, Radix Arctii 20
Part, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, 20 parts of SEMEN COICIS, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, Herba Apii graveolentis
10 parts of seed, 10 parts of Stigma Maydis, nattokinase extract is appropriate.
2. a kind of formula combination that can reduce blood pressure according to claim 1 it is characterised in that: described nattokinase carries
Take possessing of Semen Sojae Preparatum, natto, sky shellfish lyophilized powder and the dependence culture medium strain fermentation manufacture that thing is that traditional zymotic technique makes
The gene prod nattokinase of high bioactivity, is mainly used in dissolving endovascular thrombosis.
3. a kind of formula combination that can reduce blood pressure according to claim 1 it is characterised in that: described nattokinase is every
Its addition is that 50-100mg activity is 4000fu/g or daily addition is 2000fu/g for 100-200mg activity.
4. a kind of preparation method of the formula combination that can reduce blood pressure it is characterised in that: this is a kind of joining of can reducing blood pressure
The concretely comprising the following steps of the preparation method of Fang Zuhe:
S1: stirring mixing, filter stock: by 20 parts of eucommia Bark male flower, 35 parts of earthworm protein powder, 20 parts of Flos Chrysanthemi, 20 parts of Radix Puerariae is bitter
20 parts of fourth tea, 20 parts of Radix Arctii, 20 parts of Semen Cassiae, 20 parts of Flos Sophorae, 15 parts of Fructus Lycii, 20 parts of Fructus Crataegi, 20 parts of Semen Ginkgo, SEMEN COICIS 20
Part, 30 parts of Radix Et Rhizoma Fagopyri Tatarici, 10 parts of celery seed, 10 parts of Stigma Maydis are placed in clean beaker, add appropriate water to carry out adding in beaker
Thermal agitation, mixed raw material filtration treatment the pasty state raw material after retaining drainage；
S2: raw material centrifugal treating: the pasty state raw material after filtering in step s1 is obtained, and pasty state raw material is placed in centrifugation spinner
In carry out centrifugal treating, and supernatant is removed；
S3: raw material drying sterilization treatment: the raw material after centrifugation is placed in culture dish, the culture dish with raw material after centrifugation is put
In heating furnace, sterilization treatment is dried to the raw material after centrifugation using dry heat sterilization；
S4: pressing mold pelletization treatment: shape is placed in corresponding mould as needed by the raw material after dry sterilization in step s3, by mould
It is placed in drying chamber after tool lid and carries out drying and processing, after drying, add the product required for nattokinase extract is obtained in right amount；
S5: packaging chilling treatment: the product packaging being obtained in step s4 is placed in cold room cold preservation, temperature of refrigerating chamber is 0-4
Degree Celsius.
5. a kind of formula combination that can reduce blood pressure according to claim 4 preparation method it is characterised in that: described
Add water in step s1 and just do not had raw material, heating adopts heating in water bath, heating-up temperature is 60-80 degree Celsius.
6. a kind of formula combination that can reduce blood pressure according to claim 4 preparation method it is characterised in that: described
On step s3 culture dish, the thickness of raw material is 6-8 millimeter.
7. a kind of formula combination that can reduce blood pressure according to claim 4 preparation method it is characterised in that: described
In step s3, the temperature of sterilizing is 120-140 degree Celsius, and sterilization time is 2-4 hour.
8. a kind of formula combination that can reduce blood pressure according to claim 4 preparation method it is characterised in that: described
Product in step s4 can be changed to the size of mould for the medicament combining in proportion making tablet, ball according to required
Agent, granule or capsule.
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| WO2020262005A1 (en) * | 2019-06-24 | 2020-12-30 | 小林製薬株式会社 | Solid composition containing processed product of du-zhong |
| CN112535225A (en) * | 2020-09-23 | 2021-03-23 | 梧州市华夏医药科技有限公司 | Eucommia ulmoides male flower substitutional tea and preparation method thereof |
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Application publication date: 20170201 |