CN109329671A - A kind of edible drink product and preparation method thereof for treating gout - Google Patents
A kind of edible drink product and preparation method thereof for treating gout Download PDFInfo
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- CN109329671A CN109329671A CN201811357286.3A CN201811357286A CN109329671A CN 109329671 A CN109329671 A CN 109329671A CN 201811357286 A CN201811357286 A CN 201811357286A CN 109329671 A CN109329671 A CN 109329671A
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- China
- Prior art keywords
- water extract
- fructus arctii
- mixing
- cordyceps militaris
- gout
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- 201000005569 Gout Diseases 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 80
- 239000000284 extract Substances 0.000 claims abstract description 79
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 65
- 241001264174 Cordyceps militaris Species 0.000 claims abstract description 42
- 241000233866 Fungi Species 0.000 claims abstract description 32
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 29
- 240000005528 Arctium lappa Species 0.000 claims abstract description 22
- 238000000605 extraction Methods 0.000 claims abstract description 14
- 150000004676 glycans Polymers 0.000 claims abstract description 12
- 235000008078 Arctium minus Nutrition 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 97
- 239000000843 powder Substances 0.000 claims description 33
- 239000007788 liquid Substances 0.000 claims description 21
- 239000000047 product Substances 0.000 claims description 21
- 238000002386 leaching Methods 0.000 claims description 20
- 239000008367 deionised water Substances 0.000 claims description 16
- 229910021641 deionized water Inorganic materials 0.000 claims description 16
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 16
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 15
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims description 11
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 10
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 claims description 10
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 claims description 10
- 229940088598 enzyme Drugs 0.000 claims description 10
- 229920001282 polysaccharide Polymers 0.000 claims description 10
- 239000005017 polysaccharide Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 101000693530 Staphylococcus aureus Staphylokinase Proteins 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract description 10
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract description 9
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- 235000013361 beverage Nutrition 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
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- 210000003734 kidney Anatomy 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 201000001431 Hyperuricemia Diseases 0.000 description 2
- 208000000913 Kidney Calculi Diseases 0.000 description 2
- 206010029148 Nephrolithiasis Diseases 0.000 description 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
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- 239000000796 flavoring agent Substances 0.000 description 2
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- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
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- RYYCJUAHISIHTL-UHFFFAOYSA-N 5-azaorotic acid Chemical compound OC(=O)C1=NC(=O)NC(=O)N1 RYYCJUAHISIHTL-UHFFFAOYSA-N 0.000 description 1
- RFAWQHFQFXXRQB-UHFFFAOYSA-N Arctigenin 4'-gentiobioside Natural products CC1OC(OC2C(O)C(O)C(CO)OC2OC3C(O)C(O)C(OC4CCC5(C)C(CCC6(C)C5CC=C7C8CC(C)(C)CC(O)C8(C)CCC67C)C4(C)CO)OC3C(=O)O)C(O)C(O)C1O RFAWQHFQFXXRQB-UHFFFAOYSA-N 0.000 description 1
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- 208000024172 Cardiovascular disease Diseases 0.000 description 1
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- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- FEQSYBHDHIPRKS-UHFFFAOYSA-N N5-Ac-(??)-N5-Hydroxyornithine Natural products C1=C(OC)C(OC)=CC=C1CC1C(CC=2C=C(OC)C(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(CO)O4)O)O3)O)=CC=2)C(=O)OC1 FEQSYBHDHIPRKS-UHFFFAOYSA-N 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
- 229960003459 allopurinol Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BPYGTFFYYOWDBC-LOVSFRALSA-N arctiin Natural products COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc3ccc(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c3)cc1OC BPYGTFFYYOWDBC-LOVSFRALSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
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- 230000037213 diet Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000026234 goat disease Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229950000193 oteracil Drugs 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 230000003424 uricosuric effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
- A23L2/04—Extraction of juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of edible drink products and preparation method thereof for treating gout, belong to food processing technology field.The present invention first passes through pretreatment, fructus arctii extraction, is spray-dried obtained fructus arctii water extract, low temperature, which is concentrated, is made Cordyceps militaris water extract, the obtained black fungus water extract of ultrasound, again by fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract, ultraviolet-sterilization after being mixed in proportion, component pack, is made solid beverage.The vigor of Cordyceps militaris extract enhancing cellular immune mechanism in the present invention, it is improved human body immune-base, burdock extract reduces blood uric acid concentration, improves gout illness, and the polysaccharide structures of black fungus improve immunity of organisms, Cordyceps militaris effect is enabled to be consolidated, three is used cooperatively, and makes us body repeats itself adjustment function and is excited, hepatic and renal function is gradually recovered, acid, cold habitus is improved, thus a possibility that reducing the breaking-out of subsequent gout.
Description
Technical field
The invention belongs to food processing technology fields, specifically, more particularly to a kind of for treating the edible drink of gout
Product and preparation method thereof.
Background technique
Goat seriously perplexs human lives, mainly since internal uric acid concentration is higher than blood solvability (>
360umol/L), sodium urate crystals are caused to deposit in soft tissue, joint, these depositing crystallines cause soft tissue, joint and bone group
Inflammatory severe pain is knitted repeatedly, patients ' life quality is seriously reduced.Mostly use allopurinol, uricosuric row greatly currently on the market
Drug and diuretic are let out to reduce uric acid concentration in human body, but these drugs have stronger side effect to liver and kidney, increase
Patient liver, kidney burden, or even be easy to cause gastrointestinal tract and cardiovascular disease, there is higher risk.
Summary of the invention
It is effectively relieved that gout breaking-out pain, organic contamination is few, full of nutrition is used for it is an object of that present invention to provide a kind of
The edible drink product and preparation method thereof for treating gout.
The technical scheme of the invention to solve the technical problem is:
It is a kind of for treating the edible drink product of gout, the raw material including following parts by weight: 30~40 parts of fructus arctii water extract,
25~35 parts of Cordyceps militaris water extract, 20~30 parts of black fungus water extract.
It is a kind of for treating the preparation method of the edible drink product of gout, comprising the following steps:
(1) fructus arctii pre-processes: fresh burdock being removed the peel, slice is placed in baking oven, is crushed after 120~150 DEG C of drying
20 meshes are crossed, the ether of 2 times of volumes is added, stirs 2h at room temperature, filter residue is collected by filtration, then respectively with 95% second of 2 times of volumes
Alcoholic solution and the water of 2 times of volumes are washed, and fructus arctii dry powder is made after dry；
(2) fructus arctii extracts: by the ultra-fine 40min of fructus arctii dry powder, fructus arctii dry powder being made to reach 120 mesh, presses feed liquid weight ratio respectively
It adds deionized water for 1:8 and 1:10 to size mixing, obtained A sizes mixing to size mixing with B, sizes mixing to A respectively and B sizes mixing middle addition complex enzyme system
Agent is digested, while being set 100W for ultrasonic power and being carried out assisted extraction, and cooling, centrifugation after enzymatic hydrolysis takes supernatant
Liquid filtering, is made A great burdock achene leaching liquor and B great burdock achene leaching liquor respectively；
(3) fructus arctii water extract: mixing A great burdock achene leaching liquor and B great burdock achene leaching liquor are concentrated into 20% after mixing evenly,
Spray drying, makes polyoses content reach 15%, and fructus arctii water extract is made；
(4) Cordyceps militaris extracts: Cordyceps militaris is crushed to 20 mesh, then ultra-fine 40min, it is 0.06% that cordycepin content, which is made,
The Cordyceps militaris coarse powder that Cordyceps sinensis polysaccharide content is 1.6% is respectively that 1:6,1:8 and 1:10 add deionized water by feed liquid weight ratio
It sizes mixing, obtained C sizes mixing, D sizes mixing and E sizes mixing, and C sizes mixing, D sizes mixing and E sizes mixing stirs evenly for mixing, sprays after low temperature concentration
Mist is dry, and it is 0.8% that cordycepin content, which is made, the Cordyceps militaris water extract that Cordyceps sinensis polysaccharide content is 8%；
(5) black fungus extracts: cleaning black fungus raw material, and removal surface impurity is placed in drying box freeze-day with constant temperature to perseverance
Weight, is crushed to 60~80 mesh, is that 1:30 addition deionized water is sized mixing by feed liquid weight ratio, 3~5h of reconciliation, while will be ultrasonic
Wave power is set as 100W and carries out assisted extraction, and spray drying, fluidized drying after reconciliation, it is 20% that polyoses content, which is made,
Black fungus water extract；
(6) fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract are mixed in proportion, are mixed ultraviolet after 3h
Sterilization, component pack.
Preferably, complex enzyme formulation includes following enzyme preparation in the step (2): 5000~10000U/ of neutral proteinase
G, 30000~60000U/g of cellulase.
Preferably, the neutral proteinase additional amount is the 0.2%~0.3% of fructus arctii dry powder weight, and cellulase is added
Amount is the 0.3%~0.5% of fructus arctii dry powder weight.The enzymatic preparations of different weight are added, are saving the base for utilizing enzymatic preparations
On plinth, extracts fructus arctii and maximize.
Preferably, the complex enzyme formulation enzymolysis process uses fiber after being prior to 60 DEG C enzymatic hydrolysis 2h of neutral proteinase again
Plain enzyme is in 60 DEG C of enzymatic hydrolysis 50min.Two kinds of enzyme preparations are used cooperatively, enzymolysis and extraction rate is enabled to be improved, while avoiding the two mixed
Close existing the problem of competing because of gesture, recovery rate is caused to decline when using.
Preferably, in the step (4) Cordyceps militaris coarse powder partial size up to 130 mesh.
Preferably, C sizes mixing and reconciles 2h in the step (4), and D, which sizes mixing, reconciles 3h, and E, which sizes mixing, reconciles 3h.It sufficiently reconciles, makes to starch
Liquid solute Distribution is uniform.
Preferably, fructus arctii water extract in the step (6), Cordyceps militaris water extract, black fungus water extract ratio be (1~
1.4): (0.8~1.2) (0.6~1).
Side's solution that the present invention is used to treat the edible drink product of gout is as follows:
Fructus arctii: composite family draft taproot class plant is warm-natured, sweet in flavor, nontoxic.Alias Great Burdock Achene, Fructus Arctii, pizzle dish etc..Ox
Burdock and radix bardanae can both be used as medicine or edible, belong to strong basicity food, and having reduces blood uric acid concentration, improve goat
Disease adjusts the effect of acidic constitution.
Cordyceps militaris: its fructification and polypide can be used as cordyceps sinensis and be used as medicine, and have liver and kidney benefiting, kidney tonifying damage, anti-cancer, anticancer etc.
Effect can enhance the vigor of cellular immune mechanism, be improved human body immune-base；
Black fungus: it is sweet in flavor, light, mild-natured, nontoxic, tool nourishing, QI invigorating, cool blood, invigorate blood circulation, enrich blood, moisturizing, clearing lung-heat, relieving the five internal organs,
A surname's intestines build stomach, ecchymose removing disappears mole.
Compared with prior art, the beneficial effects of the present invention are:
1, the present invention drinks fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract hybrid process at complex solid
Expect, the vigor of the peroxidase enhancing cellular immune mechanism contained in Cordyceps militaris extract repairs hepatic and renal function, exempts from human body
Epidemic disease basis is improved, and burdock extract is recycled to reduce blood uric acid concentration, improves gout illness, mitigates patient with gout pain
Hardship, while immunity of organisms is improved using the polysaccharide structures of black fungus, enable Cordyceps militaris effect be consolidated, three is used cooperatively,
Making us body repeats itself adjustment function to be excited, hepatic and renal function is gradually recovered, and acid, cold habitus is improved, from
And a possibility that reducing the breaking-out of subsequent gout, and the present invention uses food for raw material, and it is highly-safe, it is beneficial to human liver, kidney
Functional rehabilitation has stronger generalization；
2, based on fructus arctii in the present invention, Cordyceps militaris and black fungus are extracted and extracted with deionized water, supplemented by enzymolysis and extraction,
The biological of raw material is made full use of, not only active constituent content is high, but also extraction process, without chemical reagent, organic contamination is few, clean
Cleanliness is high；
3, the present invention has rich in effective active compositions such as polysaccharide, amino acid, arctiin, arctigenin-4'-gentiobioside, adenosine, cordycepins
Nutritive value and healthcare function abundant.
Detailed description of the invention
Fig. 1 is uric acid concentration in each group mice serum.
Specific embodiment
With reference to the accompanying drawings of the specification and specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments
It is only illustrative of the invention and is not intended to limit the scope of the invention, after the present invention has been read, those skilled in the art couple
The modification of various equivalent forms of the invention falls within the application range as defined in the appended claims.
It is a kind of for treating the edible drink product of gout, the raw material including following parts by weight: 30~40 parts of fructus arctii water extract,
25~35 parts of Cordyceps militaris water extract, 20~30 parts of black fungus water extract.
The preparation method of the edible drink product using specific embodiment to the present invention for treating gout is made further below
Detailed description.
Embodiment 1
(1) fructus arctii pre-processes: fresh burdock being removed the peel, slice is placed in baking oven, crushed 20 mesh after 120 DEG C of drying
Sieve, is added the ether of 2 times of volumes, stirs 2h at room temperature, filter residue is collected by filtration, then respectively with 95% ethanol solution of 2 times of volumes
It is washed with the water of 2 times of volumes, fructus arctii dry powder is made after dry；
(2) fructus arctii extracts: by the ultra-fine 40min of fructus arctii dry powder, fructus arctii dry powder being made to reach 120 mesh, presses feed liquid weight ratio respectively
It adds deionized water for 1:8 and 1:10 to size mixing, obtained A sizes mixing to size mixing with B, sizes mixing to A size mixing that middle that fructus arctii is first added is dry with B respectively
The neutral proteinase 5000U/g of powder weight 0.2% adds the cellulase of fructus arctii dry powder weight 0.3% in 60 DEG C of enzymatic hydrolysis 2h
30000U/g in 60 DEG C of enzymatic hydrolysis 50min, while setting 100W for ultrasonic power and carrying out assisted extraction, cold after enzymatic hydrolysis
But, it is centrifuged, takes supernatant liquid filtering, A great burdock achene leaching liquor and B great burdock achene leaching liquor is made respectively；
(3) fructus arctii water extract: mixing A great burdock achene leaching liquor and B great burdock achene leaching liquor are concentrated into 20% after mixing evenly,
Spray drying, makes polyoses content reach 15%, and fructus arctii water extract is made；
(4) Cordyceps militaris extracts: Cordyceps militaris is crushed to 20 mesh, then ultra-fine 40min, it is 0.06% that cordycepin content, which is made,
Cordyceps sinensis polysaccharide content is 1.6%, and partial size is respectively 1:6,1:8 and 1:10 by feed liquid weight ratio up to the Cordyceps militaris coarse powder of 130 mesh
Addition deionized water is sized mixing, and obtained C sizes mixing, D sizes mixing and E sizes mixing, and C, which sizes mixing, reconciles 2h, and D, which sizes mixing, reconciles 3h, and E sizes mixing reconciliation
3h, C sizes mixing, D sizes mixing and E sizes mixing stirs evenly for mixing, is spray-dried after low temperature concentration, and it is 0.8% that cordycepin content, which is made,
The Cordyceps militaris water extract that Cordyceps sinensis polysaccharide content is 8%；
(5) black fungus extracts: cleaning black fungus raw material, and removal surface impurity is placed in drying box freeze-day with constant temperature to perseverance
Weight, is crushed to 60 mesh, is that 1:30 adds deionized water and sizes mixing by feed liquid weight ratio, reconciles 3h, while by ultrasonic power
It is set as 100W and carries out assisted extraction, the black fungus that polyoses content is 20% is made in spray drying, fluidized drying after reconciliation
Water extract；
(6) 1:0.8:0.6 mixing fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract are pressed, 3h is mixed
Ultraviolet-sterilization afterwards, component pack.
Embodiment 2
(1) fructus arctii pre-processes: fresh burdock being removed the peel, slice is placed in baking oven, crushed 20 mesh after 150 DEG C of drying
Sieve, is added the ether of 2 times of volumes, stirs 2h at room temperature, filter residue is collected by filtration, then respectively with 95% ethanol solution of 2 times of volumes
It is washed with the water of 2 times of volumes, fructus arctii dry powder is made after dry；
(2) fructus arctii extracts: by the ultra-fine 40min of fructus arctii dry powder, fructus arctii dry powder being made to reach 120 mesh, presses feed liquid weight ratio respectively
It adds deionized water for 1:8 and 1:10 to size mixing, obtained A sizes mixing to size mixing with B, sizes mixing to A size mixing that middle that fructus arctii is first added is dry with B respectively
The neutral proteinase 10000U/g of powder weight 0.3% adds the cellulose of fructus arctii dry powder weight 0.5% in 60 DEG C of enzymatic hydrolysis 2h
Enzyme 60000U/g in 60 DEG C of enzymatic hydrolysis 50min, while setting 100W for ultrasonic power and carrying out assisted extraction, after enzymatic hydrolysis
Cooling, centrifugation, takes supernatant liquid filtering, and A great burdock achene leaching liquor and B great burdock achene leaching liquor are made respectively；
(3) fructus arctii water extract: mixing A great burdock achene leaching liquor and B great burdock achene leaching liquor are concentrated into 20% after mixing evenly,
Spray drying, makes polyoses content reach 15%, and fructus arctii water extract is made；
(4) Cordyceps militaris extracts: Cordyceps militaris is crushed to 20 mesh, then ultra-fine 40min, it is 0.06% that cordycepin content, which is made,
Cordyceps sinensis polysaccharide content is 1.6%, and partial size is respectively 1:6,1:8 and 1:10 by feed liquid weight ratio up to the Cordyceps militaris coarse powder of 130 mesh
Addition deionized water is sized mixing, and obtained C sizes mixing, D sizes mixing and E sizes mixing, and C, which sizes mixing, reconciles 2h, and D, which sizes mixing, reconciles 3h, and E sizes mixing reconciliation
3h, C sizes mixing, D sizes mixing and E sizes mixing stirs evenly for mixing, is spray-dried after low temperature concentration, and it is 0.8% that cordycepin content, which is made,
The Cordyceps militaris water extract that Cordyceps sinensis polysaccharide content is 8%；
(5) black fungus extracts: cleaning black fungus raw material, and removal surface impurity is placed in drying box freeze-day with constant temperature to perseverance
Weight, is crushed to 80 mesh, is that 1:30 adds deionized water and sizes mixing by feed liquid weight ratio, reconciles 5h, while by ultrasonic power
It is set as 100W and carries out assisted extraction, the black fungus that polyoses content is 20% is made in spray drying, fluidized drying after reconciliation
Water extract；
(6) 1.4:1.2:1 mixing fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract are pressed, 3h is mixed
Ultraviolet-sterilization afterwards, component pack.
Embodiment 3
(1) fructus arctii pre-processes: fresh burdock being removed the peel, slice is placed in baking oven, crushed 20 mesh after 135 DEG C of drying
Sieve, is added the ether of 2 times of volumes, stirs 2h at room temperature, filter residue is collected by filtration, then respectively with 95% ethanol solution of 2 times of volumes
It is washed with the water of 2 times of volumes, fructus arctii dry powder is made after dry；
(2) fructus arctii extracts: by the ultra-fine 40min of fructus arctii dry powder, fructus arctii dry powder being made to reach 120 mesh, presses feed liquid weight ratio respectively
It adds deionized water for 1:8 and 1:10 to size mixing, obtained A sizes mixing to size mixing with B, sizes mixing to A size mixing that middle that fructus arctii is first added is dry with B respectively
The neutral proteinase 75000U/g of powder weight 0.25% adds the cellulose of fructus arctii dry powder weight 0.4% in 60 DEG C of enzymatic hydrolysis 2h
Enzyme 45000U/g in 60 DEG C of enzymatic hydrolysis 50min, while setting 100W for ultrasonic power and carrying out assisted extraction, after enzymatic hydrolysis
Cooling, centrifugation, takes supernatant liquid filtering, and A great burdock achene leaching liquor and B great burdock achene leaching liquor are made respectively；
(3) fructus arctii water extract: mixing A great burdock achene leaching liquor and B great burdock achene leaching liquor are concentrated into 20% after mixing evenly,
Spray drying, makes polyoses content reach 15%, and fructus arctii water extract is made；
(4) Cordyceps militaris extracts: Cordyceps militaris is crushed to 20 mesh, then ultra-fine 40min, it is 0.06% that cordycepin content, which is made,
Cordyceps sinensis polysaccharide content is 1.6%, and partial size is respectively 1:6,1:8 and 1:10 by feed liquid weight ratio up to the Cordyceps militaris coarse powder of 130 mesh
Addition deionized water is sized mixing, and obtained C sizes mixing, D sizes mixing and E sizes mixing, and C, which sizes mixing, reconciles 2h, and D, which sizes mixing, reconciles 3h, and E sizes mixing reconciliation
3h, C sizes mixing, D sizes mixing and E sizes mixing stirs evenly for mixing, is spray-dried after low temperature concentration, and it is 0.8% that cordycepin content, which is made,
The Cordyceps militaris water extract that Cordyceps sinensis polysaccharide content is 8%；
(5) black fungus extracts: cleaning black fungus raw material, and removal surface impurity is placed in drying box freeze-day with constant temperature to perseverance
Weight, is crushed to 70 mesh, is that 1:30 adds deionized water and sizes mixing by feed liquid weight ratio, reconciles 4h, while by ultrasonic power
It is set as 100W and carries out assisted extraction, the black fungus that polyoses content is 20% is made in spray drying, fluidized drying after reconciliation
Water extract；
(6) 1.2:1:0.8 mixing fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract are pressed, 3h is mixed
Ultraviolet-sterilization afterwards, component pack.
Anti-trioxypurine experiment is carried out to embodiment one, embodiment two, the made object of embodiment three: taking 30 mouse, is randomly divided into
5 groups: Normal group, hyperuricemia control group, one control group of embodiment, two control group of embodiment, three control group of embodiment.
In addition to Normal group intraperitoneal injection and stomach-filling physiological saline, Oxonic Acid is injected intraperitoneally according to the dosage of 100mg/kg/d in other groups
Sylvite, while the hypoxanthine modeling of stomach-filling 300mg/kg/d dosage, after modeling, one control group stomach-filling 50mg/kg/d of embodiment
The object processed of embodiment one of dosage, the object processed of embodiment two of two control group stomach-filling 50mg/kg/d dosage of embodiment, embodiment three compare
The object processed of embodiment three of group stomach-filling 50mg/kg/d dosage, Normal group and hyperuricemia control group then fill same volume
Physiological saline detects uric acid in serum concentration, as a result as shown in Figure 1 after continuous stomach-filling in 15 days.
From figure 1 it appears that the edible drink product that the present invention is used to treat gout has good anti-trioxypurine effect, together
When Cordycepps and plant section as integration of drinking and medicinal herbs of fructus arctii, Cordyceps militaris and black fungus, not only to human zero damage, but also have rich
Rich nutritive value.
Use embodiment
According to edible drink product prepared by the embodiment of the present invention 1~3, three times per day, primary two~tri- bags.
Patient with gout raises so-and-so, male, and 55 years old, Yangzhou central enterprise administrative staff, the right toes of patient, sufficient bowl repeatability swelling and pain
More than 20 years, long-term rely on took the gouts class drug such as Ying Taiqing, colchicin, and drug effect of taking medicine over the past two years is decreased obviously, gout
The frequency of attack obviously increases, 2-3 times monthly.
Physical examination: constitution is seriously weak, does not think ordinary food and drink, looks wane and sallow, concurrent uric acid type kidney stone (two), blood uric acid:
720-760umol/L, kidney function indicator are deteriorated year by year.
In January, 2018 begins to use the present invention for treating the edible drink product of gout, three times per day, primary two~tri-
Bag, pain relief after one month are taken half a year, and ventilation the frequency of attack significantly reduces (only breaking-out is primary after in June, 2018), i.e.,
So that breaking-out is not also taken colchicin etc anti-trioxypurine drug again, need to only increase edible drink product dose.Take half a year
Kidney stone reduces one afterwards, and a remaining size obviously becomes smaller, and the indexs such as kidney function indicator, blood-fat and blood sugar have to be changed greatly very much
Kind, existing diet is without abstaining from bean product, seafood and drinks.
Claims (8)
1. a kind of edible drink product and preparation method thereof for treating gout, it is characterised in that: the original including following parts by weight
Material: 30~40 parts of fructus arctii water extract, 25~35 parts of Cordyceps militaris water extract, 20~30 parts of black fungus water extract.
2. it is according to claim 1 for treat gout edible drink product preparation method, it is characterised in that: including with
Lower step:
(1) fructus arctii pre-processes: fresh burdock being removed the peel, slice is placed in baking oven, crushed 20 after 120~150 DEG C of drying
Mesh is added the ether of 2 times of volumes, stirs 2h at room temperature, and filter residue is collected by filtration, then 95% ethyl alcohol respectively with 2 times of volumes is molten
Liquid and the water of 2 times of volumes are washed, and fructus arctii dry powder is made after dry；
(2) fructus arctii extracts: by the ultra-fine 40min of fructus arctii dry powder, fructus arctii dry powder being made to reach 120 mesh, is respectively 1:8 by feed liquid weight ratio
With 1:10 addition deionized water size mixing, obtained A sizes mixing to size mixing with B, respectively to A size mixing with B size mixing middle addition complex enzyme formulation into
Row enzymatic hydrolysis, while setting 100W for ultrasonic power and carrying out assisted extraction, cooling, centrifugation after enzymatic hydrolysis takes supernatant mistake
A great burdock achene leaching liquor and B great burdock achene leaching liquor is made in filter respectively；
(3) fructus arctii water extract: mixing A great burdock achene leaching liquor and B great burdock achene leaching liquor are concentrated into 20% after mixing evenly, spraying
It is dry, so that polyoses content is reached 15%, fructus arctii water extract is made；
(4) Cordyceps militaris extracts: Cordyceps militaris being crushed to 20 mesh, then ultra-fine 40min, it is 0.06% that cordycepin content, which is made, cordyceps sinensis
The Cordyceps militaris coarse powder that polyoses content is 1.6% is respectively that 1:6,1:8 and 1:10 add deionized water tune by feed liquid weight ratio
Slurry, obtained C sizes mixing, D sizes mixing and E sizes mixing, and C sizes mixing, D sizes mixing and E sizes mixing stirs evenly for mixing, does by spraying after low temperature concentration
Dry, it is 0.8% that cordycepin content, which is made, the Cordyceps militaris water extract that Cordyceps sinensis polysaccharide content is 8%；
(5) black fungus extracts: cleaning black fungus raw material, and removal surface impurity is placed in drying box freeze-day with constant temperature to constant weight, powder
60~80 mesh are broken to, are that 1:30 adds deionized water and sizes mixing by feed liquid weight ratio, reconcile 3~5h, while by ultrasonic wave function
Rate is set as 100W and carries out assisted extraction, and the black wood that polyoses content is 20% is made in spray drying, fluidized drying after reconciliation
Ear water extract；
(6) fructus arctii water extract, Cordyceps militaris water extract and black fungus water extract are mixed in proportion, and ultraviolet after 3h kill is mixed
Bacterium, component pack.
3. according to claim 2 for treating the preparation method of the edible drink product of gout, it is characterised in that: the step
Suddenly complex enzyme formulation includes following enzyme preparation in (2): 5000~10000U/g of neutral proteinase, and cellulase 30000~
60000U/g。
4. according to claim 3 for treating the preparation method of the edible drink product of gout, it is characterised in that: in described
Property protease additional amount be the 0.2%~0.3% of fructus arctii dry powder weight, cellulase additional amount is fructus arctii dry powder weight
0.3%~0.5%.
5. according to claim 4 for treating the preparation method of the edible drink product of gout, it is characterised in that: described multiple
Synthase preparation enzymolysis process uses cellulase in 60 DEG C of enzymatic hydrolysis 50min again after being prior to 60 DEG C enzymatic hydrolysis 2h of neutral proteinase.
6. according to claim 2 for treating the preparation method of the edible drink product of gout, it is characterised in that: the step
Suddenly in (4) Cordyceps militaris coarse powder partial size up to 130 mesh.
7. according to claim 2 for treating the preparation method of the edible drink product of gout, it is characterised in that: the step
Suddenly C sizes mixing and reconciles 2h in (4), and D, which sizes mixing, reconciles 3h, and E, which sizes mixing, reconciles 3h.
8. according to claim 2 for treating the preparation method of the edible drink product of gout, it is characterised in that: the step
Suddenly fructus arctii water extract in (6), Cordyceps militaris water extract, black fungus water extract ratio be (1~1.4): (0.8~1.2) (0.6~
1)。
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