CN106344654A - Anti-fatigue traditional Chinese medicine preparation containing herba euonymi - Google Patents

Anti-fatigue traditional Chinese medicine preparation containing herba euonymi Download PDF

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CN106344654A
CN106344654A CN201610857543.4A CN201610857543A CN106344654A CN 106344654 A CN106344654 A CN 106344654A CN 201610857543 A CN201610857543 A CN 201610857543A CN 106344654 A CN106344654 A CN 106344654A
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preparation
fatigue
chinese medicine
seu folium
caulis seu
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莫善列
莫佳
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A61K36/62—Nymphaeaceae (Water-lily family)
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Abstract

The invention discloses an anti-fatigue traditional Chinese medicine preparation containing herba euonymi. The anti-fatigue traditional Chinese medicine preparation is prepared from the following ingredients: the herba euonymi, radix astragali seu hedysari, poria cocos, gordon euryale seeds, licorice root and radix ginseng. The anti-fatigue traditional Chinese medicine preparation containing herba euonymi utilizes the herba euonymi as a monarch drug, and the radix astragali seu hedysari, the tuckahoe, the gordon euryale seeds, the licorice root and the radix ginseng as adjuvant drugs, and has the efficacies of effectively and rapidly eliminating fatigue and continously resisting fatigue for a long time.

Description

A kind of anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei
Technical field
The invention belongs to pharmaceutical technology field is and in particular to a kind of anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei.
Background technology
Because modern's rhythm of life is fast, working strength is big, and youngster suffers from fatigue ratio more and more higher.Fatigue is people The chronic fatigue syndrome that chronic fatigue causes, the modal call of chronic fatigue syndrome is chronic fatigue Syndrome(abbreviation cfs).
The symptom of generally performance is:
1. the symptom of psychological aspects:
The Novel presentation of chronic fatigue syndrome psychological aspects sometimes occurs early than the symptom of body aspect, feels More prominent.Majority shows as feeling depressed, anxious or irritable, irritability, and emotional lability is short-tempered, and the state of mind is chaotic, instead Should be blunt, hypomnesis, absent minded, shortage of doing things confidence, irresolute.
2. the symptom of body aspect:
Build appearance: the build of chronic fatigue syndrome is often rendered as thin, fat two classes.Should say that most is lean body mass, But nor exclusion minority may show that figure is fat.Latter class patient chronic fatigue syndrome in modern society is not Rare.Then majority shows as presenility, lusterless complexion to face, facial wrinkles or pigmented spots too early；Limb skin is coarse, Dry and astringent, desquamation is more；Refer to (toe) first and lose normally smooth and gloss；Alopecia, fluffy dirt, easily broken, loss of gloss.
3. the symptom of motor system aspect:
Whole body is tired out, limbs fatigue, and the whole body is uncomfortable, and activity is slow.There may come a time when that flu-like symptoms occur, myalgia, joint Pain etc., if the time is longer, accumulates several months or several years, then shows particularly evident, can have the sense that a kind of severe disease is burdened with.
4. the symptom of digestive system aspect:
It is mainly shown as loss of appetite, appetite is all lacked to various food, especially with greasy for writing.No hunger sensation, there may come a time when out Existing monophagia, dyspepsia after food, abdominal distention；There is change stool shape, constipation, drying or times of defecation increase more.
5. the symptom of nervous system aspect:
Show lassitude or psychentonia, often there are dizziness, insomnia, nervous, irritability etc. at the initial stage；Stage shows as sleep not Foot, dreaminess, fright at night, middle early awakening, insomnia etc., or even the symptom such as drowsiness, dispirited, slack, hypomnesis.
6. the symptom of genitourinary system aspect:
With psychological problem, frequent micturition can there is, the urinary system symptom such as urgent micturition.Additionally, the people that fatigue is exaggerated, arrange in a reservoir Urine is easiest to spume, and the foam time of staying is permanent., seminal emission, sexual impotence, premature ejaculation, libido in man in reproductive system symptom Go down；Menoxenia or amenorrhea in advance, hyposexuality etc. in woman.If things go on like this it may occur however that infertility.
7. the symptom of sensorium's aspect:
It is mainly shown as ocular pain in visual system, blurred vision, to photaesthesia etc.；Then it is mainly shown as ear in auditory system Ring, auditory dysesthesia etc..
Fatigue can have a strong impact on health, and affects the normal live and work of people, and usual people select to drink coffee Coffee, the mode allaying tiredness such as have tea, but when fatigue strength is excessive, these traditional modes can not play significant eliminate tired Labor effect, and allaying tiredness and resisting fatigue continuous capability all weaker, and the caffeine due to containing in coffee, drink coffee for a long time Certain side effect can be produced, be mesh therefore, it is possible to quick allaying tiredness with long lasting for the medicament having no side effect of resisting fatigue Front consumer is badly in need of.
Caulis Seu Folium Euonymi Fortunei (euonymus fortunei (turcz.) hand.-mazz.): the evergreen liana of Celastraceae Euonymus fills Wood.Height is up to several meters；Sprig side's shuttle is inconspicuous.Elliptic leaf shape, rectangular oval or long inverted ovoid, keratin, edge teeth are shallow not clear Aobvious, cyme；Cymule is spent intensive, has flower, there is single flower in branch central authorities, grey green, and floral disc is square, and filigree is elongated, flower pesticide Center of circle shape；Ovary triangle taper, capsule pink, peel smooth, closely spherical, the rectangular ellipticity of seed, sepia.Caulis Seu Folium Euonymi Fortunei is originally Body contains high medical value, and Caulis Seu Folium Euonymi Fortunei mainly contains triterpeness, flavonoid, lignin, steroid and liposoluble ingredient. With other burning buss, in Caulis Seu Folium Euonymi Fortunei, also contain dihydroagarofuran ester type compound, take orally and can play vigorate qi and replenish the blood, be good for Effect of spleen nourishing heart.
The following is the patent retrieving related resisting fatigue medicament:
Chinese patent 1, application number: 201110007916.6；Applicant: Beijing University of Chinese Medicine；A kind of denomination of invention: resisting fatigue Pharmaceutical composition；Summary: a kind of pharmaceutical composition with antifatigue effect, said composition be by the Radix Astragali, Radix Ginseng, Radix Angelicae Sinensis, The Chinese medicines such as Pericarpium Citri Reticulatae, Rhizoma Cyperi and Fructus Lycii form.Fatigue and sub-healty adults that the pharmaceutical composition of the present invention causes to a variety of causes Group has remarkable result.There is replenishing QI to invigorate the spleen, the function of soothing the liver blood-nourishing.For by deficiency of spleen-QI, hepatic depression and blood deficiency, disharmony between the liver and spleen institute The disease based on fatigue causing, shows as fatigue and weak, hypomnesis, depressed or being irritable and getting angry easily, inappetence, breast The symptoms such as the full vexed discomfort of the side of body.
Chinese patent 2, application number: 200910312277.7；Applicant: Chengdu University of Traditional Chinese Medicine；Denomination of invention: anti- Pharmaceutical composition of fatigue and preparation method thereof；Summary: the invention belongs to the medicine group of field of medicaments, specifically related to resisting fatigue Compound.The technical problem solving is to provide a kind of brand-new pharmaceutical composition to be used for resisting fatigue, and this pharmaceutical composition is by as follows The crude drug of weight proportion is prepared from: Radix Ginseng 5-15 part, Rhizoma Curcumae 10-15 part, Fructus Lycii 5-15 part, Radix Astragali 5-15 part, He Shou Black 1-10 part, Rhizoma Chuanxiong 5-15 part.Proved by pharmacological evaluation, oral, external drug regimen of the present invention has the effect of resisting fatigue. Pharmaceutical composition of the present invention is made external preparation by inventor, and cooperation massage is applied to clinic, can improve due to excessively mental labor Dynamic, physical work or spirit are chronically at the fatigue syndrome caused by anxiety, such as deficient in energy, tired sleepiness, lassitude, note The dispersion of meaning power, uncomfortable in chest, cardiopalmus, insomnia, the symptom treatment effect is significant such as forgetful.
Chinese patent 3, application number: 200710072313.8；Applicant: Yang Wanzheng；Denomination of invention: one kind has anti-tired The Chinese medicine composition of work；Summary；A kind of Chinese medicine composition with antifatigue effect, this Chinese medicine composition is by following weight The raw material of number is made: Radix Et Caulis Acanthopanacis Senticosi 2-6 part, Herba Epimedii 1-4 part, Radix Cyathulae 1-5 part, Semen Cuscutae 1-4 part, Radix Astragali 1-5 part, Fructus Hordei Germinatus 2-6 part.The medicinal preparation for oral administration dosage form that Chinese medicine composition is made is granule, capsule.The present invention has replenishing QI to invigorate the spleen, kidney-tonifying health-care, disappears Function except fatigue.The medicinal preparation for oral administration made, through taking Follow-up observation, to brain worker, the at ordinary times race of having office hours of few motion, car Driver, takes in the state of feeling fatigue, has obvious brain-strengthening, stimulating effect;Appetite strengthening, allaying tiredness, The aspect such as improving the health care of sleep, regain one's strength has preferable effect;Prescription raw material is easy to get, and has no toxic side effect.
In the patent retrieving, patent 1-3 does not all refer to the Chinese medicine preparation preparing resisting fatigue using Caulis Seu Folium Euonymi Fortunei for main formula And preparation method.
Content of the invention
The present invention be directed to the spirit being caused due to excessive mental work or physical work is sleepy, faint, be feeling too lazy to get out of bed, eat Be intended to that depressed, face is bitter, the anti-fatigue Chinese medicine preparation of seminal emission frequent micturition and the symptom such as digestive system is abnormal.
Technical scheme is as follows:
A kind of anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei of the present invention, is made up of the raw material of following parts by weight effective ingredient:
Caulis Seu Folium Euonymi Fortunei 8-20；
Radix Astragali 4-16；
Poria 5-12；
Semen Euryaless 1-5；
Radix Glycyrrhizae 3-9；
Radix Ginseng 1-5；
The preparation method of the described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is as follows:
(1) decocting of Caulis Seu Folium Euonymi Fortunei and 4-10 times of ratio of weight and number of the Radix Astragali is boiled 2 times, each 1-2 hour, obtain decocting liquid, decocting liquid mistake When being concentrated into 60 DEG C after filter, relative density is 1.44, and the volumetric concentration adding 2 times after Temperature fall is 65%-95% ethanol, stirs evenly Standing obtains preparation a in 48 hours afterwards；
(2) Poria, Semen Euryaless and Radix Glycyrrhizae are boiled 2 times with the decocting of 4-10 times of ratio of weight and number respectively, each 1-2 hour, decocted Liquid, decocting liquid filter after when being concentrated into 60 DEG C relative density be 1.44, after Temperature fall cold preservation 48 hours, obtain poria cocos preparation, Gorgon euryale Real preparation and glycyrrhiza preparation；
(3) Radix Ginseng volumetric concentration be 65%-70% alcohol heating reflux extract 2 times, each 1-2 hour, obtain extracting solution, carry When taking liquid to be concentrated into 60 DEG C after filtering, relative density is 1.44, and Temperature fall cold preservation obtained gen-seng after 48 hours；
(4) preparation a is merged with poria cocos preparation, Semen Euryaless preparation, glycyrrhiza preparation and gen-seng, be sufficiently stirred for all after reclaiming ethanol Even, add water to ormal weight and boil, make every ml medicinal liquid gross weight containing Caulis Seu Folium Euonymi Fortunei be 1-1.5g, obtain after fill described containing Caulis Seu Folium Euonymi Fortunei Anti-fatigue Chinese medicine preparation.
Each raw material that the present invention adopts and effect are introduced:
Caulis Seu Folium Euonymi Fortunei (euonymus fortunei (turcz.) hand.-mazz.): Celastraceae Euonymus evergreen liana shrub. Height is up to several meters；Sprig side's shuttle is inconspicuous.Elliptic leaf shape, rectangular oval or long inverted ovoid, keratin, edge teeth are shallow inconspicuous, Cyme；Cymule is spent intensive, has flower, there is single flower in branch central authorities, grey green, and floral disc is square, and filigree is elongated, the flower pesticide center of circle Shape；Ovary triangle taper, capsule pink, peel smooth, closely spherical, the rectangular ellipticity of seed, sepia.
Caulis Seu Folium Euonymi Fortunei mainly contains triterpeness, flavonoid, lignin, steroid and liposoluble ingredient.With other Euonymus Plant, also contains dihydroagarofuran ester type compound, the Chinese medicine characteristic of Caulis Seu Folium Euonymi Fortunei in Caulis Seu Folium Euonymi Fortunei:
Source: Celastraceae burning buss, is used as medicine with stem, leaf.Autumn in summer or whole year can adopt, and cutting is dried.
Nature and flavor: bitter, sweet, temperature.
Indication: vigorate qi and replenish the blood, dissipate stasis of blood hemostasis, relaxing muscles and tendons and activating QI and blood in the collateral.For spitting blood, menoxenia, dysfunctional uterine hemorrhage, Rheumatic arthralgia；Traumatic injury is controlled in external, fracture, wound hemorrhage.
The Radix Astragali (astragalus membranaceus (fisch.) bunge.): also known as continuous stilbene.Perennial herb is high 50-100 centimetre.Main root is plump, wooden, normal branch, canescence.Stem is upright, and top multi-branched has thin rib, by white pubescence.Many Year SHENGCAO this, high 50-100 centimetre.
The Radix Astragali mainly contains the compounds such as saponinss, flavonoid, polysaccharide and amino acidses, the Chinese medicine characteristic of the Radix Astragali:
Nature and flavor: sweet, tepor.
Return through: return lung, spleen, liver and kidney channel.
Indication: invigorating vital QI, nourishing blood and promoting granulation, hidroschesis diuretic, detumescence defying age are it is adaptable to internal injury overstrain, insufficiency of the spleen let out Rush down, the disease such as the deficiency of vital energy, blood deficiency, weakness of QI.
Poria (poria cocos (schw.) wolf), Chinese medicine name.Dry sclerotia for On Polyporaceae Poria.It is more than 7～September is excavated, and removes silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free after digging out, then " diaphoresis ", is repeated several times to now After scattering and disappearing in the big portion of wrinkle, internal moisture, dry in the shade, referred to as " Poria "；Or fresh Poria is pressed different parts cutting, dry in the shade, respectively Referred to as " Poria block " and " Indian buead tablet ".
Nature and flavor: sweet in the mouth, light, mild-natured.
Return through: GUIXIN, lung, spleen, kidney channel.
Indication: there is the effects such as invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, inducing diuresis to remove edema, cancer-resisting, blood pressure lowering strong.
Semen Euryaless (euryale ferox salisb.), Chinese medicine name.Dry mature kernal for nymphaeaceae plant Gorgon euryale.Distribution In from Heilungkiang to Yunnan, Guangdong and other places.There is the effect of supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, eliminating dampness and arresting leucorrhea.
Nature and flavor: sweet in the mouth, puckery, mild-natured.
Return through: returns spleen, kidney channel.
Indication: invigorating the spleen and replenishing QI, is nourishing robustness food, and Semen Nelumbinis are somewhat like, but the calm work of the convergence of Semen Euryaless It is adaptable to chronic diarrhea and frequent micturition, emission, women carries many soreness of waist etc. with stronger than Semen Nelumbinis, has reinforcing the kindey to control nocturnal emission, spleen reinforcing Effect of stopping leak.
Radix Glycyrrhizae (scientific name: glycyrrhiza uralensis fisch), another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet Son.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root stock, is a kind of tonification Chinese herbal medicine.To a kind of human body medicine well, Medicinal part is root and rhizome, and Medicinal Materials Characters root is in cylinder, long 25～100 centimetres, 0.6～3.5 centimetre of diameter.Crust is elastic Differ, surface rufous or taupe brown.Rhizome is in cylinder, and there is bud scar on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.
Nature and flavor: sweet in the mouth, mild-natured.
Return through: GUIXIN, spleen, lung and stomach.
Indication: heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc..
Radix Ginseng (panax ginseng c. a. mey), is herbaceos perennial, happiness cool place, blade pore-free and grid Hurdle tissue it is impossible to retain moisture, can burn higher than 32 degree of blades, canopy density 0.7-0.8 by temperature.Bloom within usual 3 years, 5-6 ties Really, the florescence 5-6 month, the fruiting period 6-9 month.The pin based on Pinus koraiensis being grown on height above sea level hundreds of meters between 33 degree -48 of north latitude degree is wealthy Mixed forest or broad leaved and deciduous broad leaved sylvan life, originate in Northeast China, Korea, Korea S, Japan, Russian east.
Nature and flavor: sweet in the mouth, slight bitter, warm in nature, flat.
Return through: returns spleen, lung meridian, heart channel.
Indication: there is QI invigorating, Gu de-, promote the production of body fluid, calm the nerves, effect of Fructus Alpiniae Oxyphyllae, cure mainly weak body and prostration, cold weak pulse of limb, spleen Empty lack of appetite, the deficiency of the lung is breathed with cough, injury thirst, Heat Diabetes, prolonged illness weakness with emaciation, insomnia of palpitating with fear, sexual impotence cold womb；Heart failure, cardiogenic Shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is powerless.
Each active princlple analysis of the above-described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei:
The we of the present invention are for insufficiency of vital energy and blood, syndrome of deficiency of both heart and spleen and set, control with vigorate qi and replenish the blood, the method for key spleen nourishing heart.Help in side Fragrant rattan, bitter in the mouth tepor, returns spleen, lung, liver and kidney channel.There is the effects such as replenishing QI and blood, invigorating the liver and kidney, be usually used in the card of insufficiency of vital energy and blood.Therefore Tang CHEN Zang-Qi supplement to the Herbal is called consumption in its " all blood, all gas " side and is solely weighed, and is to think monarch drug.Fang Zhongchen with the Radix Astragali, Poria, Radix Glycyrrhizae, Semen Euryaless and Radix Ginseng.The Radix Astragali, sweet tepor, returns spleen, lung meridian, function benefiting QI for strengthening the superficies, is important Qi-tonifying drug.All vigour is weak And see fatigue and asthenia, voice is humble, thready and weak pulse without strength person, use very easy.Poria, sweet in the mouth, light, mild-natured, GUIXIN, lung, spleen, kidney Warp, function strongly invigorating primordial QI, the strengthening the spleen and tonifying the lung benefit heart, it is usually used in all diseases of the deficiency of vital energy.Semen Euryaless, sweet in the mouth, puckery, mild-natured, returns spleen, kidney channel, invigorating middle warmer QI invigorating, is nourishing robustness food.Radix Glycyrrhizae, sweet in the mouth, mild-natured, GUIXIN, spleen, lung and stomach, there is heat-clearing and toxic substances removing, dispel the work(of heart-fire Effect.Radix Ginseng, sweet in the mouth, slight bitter, warm in nature, flat, returns spleen, lung meridian, heart channel.It is QI invigorating, the valuable medicinal calmed the nerves.
, with using, the power of its QI invigorating is higher for Caulis Seu Folium Euonymi Fortunei, the Radix Astragali, Poria, Radix Glycyrrhizae, Semen Euryaless and Radix Ginseng, and has the effect of QI invigorating and blood producing, Particularly the QI and blood deficiency such as fatigue, eak after being ill, old, neurasthenia, deficiency of both the heart and spleen card institute are suitable.Lid taste are the day after tomorrow Originally, source of generating QI and blood.With the strongly invigorating primordial QI of ginseng stilbene, the spleen invigorating benefit heart, taste are made to be good for fortune, the source of vital function is sufficient, QI and blood is filled certainly, QI and blood deficiency, the card of deficiency of both the heart and spleen can be healed, therefore can strengthen the work(of monarch drug vigorate qi and replenish the blood, is to think ministerial drug.Above three medicines share, altogether Play vigorate qi and replenish the blood, the work(of invigorating spleen and nourishing heart.For insufficiency of vital energy and blood, the card of deficiency of both the heart and spleen.Plus Poria, Semen Euryaless two taste, promote adjustment Spleen and stomach function it is possible to reach regains one's strength, effect of resisting fatigue.
Compared with prior art, the positive effect of the present invention is:
1st, the present invention using modern Chinese medicine preparation technology it is ensured that having that preparation safety, extracts active ingredients effect be good, the holding time Grow, take portable advantage.A kind of simple, safe and efficient PROCESS FOR TREATMENT Caulis Seu Folium Euonymi Fortunei, the Radix Astragali, Poria, Radix Glycyrrhizae, Semen Euryaless are provided And Radix Ginseng, in theory of Chinese medical science, different medicines needs different processing modes, and the preparation technology that the present invention selects can meet simultaneously The extraction of Caulis Seu Folium Euonymi Fortunei, the Radix Astragali, Poria, Radix Glycyrrhizae, Semen Euryaless and ginseng effective component, simplifies preparation process, reduced cost significantly.
2, present invention optimizes the invention " composite catechu capsulae " of the present inventor's early stage, are not added using other chemical compositions Plus agent, full Chinese medicine formula, will not have side effects, be suitable for full age bracket and take, the Poria adding, Semen Euryaless and Radix Ginseng on formula more The weary effect of anti-tired drive can be significantly improved.Modern's rhythm of life is fast, and pressure is larger, often feels fatigue, and the present invention can improve Cardiac muscle tolerance hypoxia ability, protecting myocardial cell, increase coronary blood flow, improve myocardial ischemia, thus strengthening anti- Fatigue capability.Improve content of hemoglobin, raise RBC number and leukocyte count, strengthen hemopoietic function fast quick-recovery strength, have Effect drives away fatigue.
Specific embodiment:
Embodiment 1
Anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei, is made up of the raw material of following parts by weight effective ingredient:
Caulis Seu Folium Euonymi Fortunei 8；
The Radix Astragali 4；
Poria 5；
Semen Euryaless 1；
Radix Glycyrrhizae 3；
Radix Ginseng 1；
The preparation method of the described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is as follows:
(1) decocting of Caulis Seu Folium Euonymi Fortunei and 4-10 times of ratio of weight and number of the Radix Astragali is boiled 2 times, 1 hour every time, obtain decocting liquid, decocting liquid filters After when being concentrated into 60 DEG C relative density be 1.44, the volumetric concentration adding 2 times after Temperature fall is 65% ethanol, stands after stirring evenly Obtain preparation a within 48 hours；
(2) Poria, Semen Euryaless and Radix Glycyrrhizae are boiled 2 times with the decocting of 4 times of ratios of weight and number respectively, 1 hour every time, obtain decocting liquid, decoct Liquid filter after when being concentrated into 60 DEG C relative density be 1.44, after Temperature fall cold preservation 48 hours, obtain poria cocos preparation, Semen Euryaless preparation And glycyrrhiza preparation；
(3) Radix Ginseng volumetric concentration be 65%% alcohol heating reflux extract 2 times, 1 hour every time, obtain extracting solution, extracting solution When being concentrated into 60 DEG C after filtration, relative density is 1.44, and Temperature fall cold preservation obtained gen-seng after 48 hours；
(4) preparation a is merged with poria cocos preparation, Semen Euryaless preparation, glycyrrhiza preparation and gen-seng, be sufficiently stirred for all after reclaiming ethanol Even, add water to ormal weight and boil, make every ml medicinal liquid gross weight containing Caulis Seu Folium Euonymi Fortunei be 1-1.5g, obtain after fill described containing Caulis Seu Folium Euonymi Fortunei Anti-fatigue Chinese medicine preparation.
Embodiment 2
Anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei, is made up of the raw material of following parts by weight effective ingredient:
Caulis Seu Folium Euonymi Fortunei 15；
The Radix Astragali 8；
Poria 7；
Semen Euryaless 3；
Radix Glycyrrhizae 6；
Radix Ginseng 6；
The preparation method of the described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is as follows:
(1) decocting of Caulis Seu Folium Euonymi Fortunei and 6 times of ratios of weight and number of the Radix Astragali is boiled 2 times, 1 hour every time, obtain decocting liquid, decocting liquid is dense after filtering When being reduced to 60 DEG C, relative density is 1.44, and the volumetric concentration adding 2 times after Temperature fall is 80% ethanol, and after stirring evenly, standing 48 is little When obtain preparation a；
(2) Poria, Semen Euryaless and Radix Glycyrrhizae are boiled 2 times with the decocting of 6 times of ratios of weight and number respectively, 1 hour every time, obtain decocting liquid, decoct Liquid filter after when being concentrated into 60 DEG C relative density be 1.44, after Temperature fall cold preservation 48 hours, obtain poria cocos preparation, Semen Euryaless preparation And glycyrrhiza preparation；
(3) Radix Ginseng volumetric concentration be 70% alcohol heating reflux extract 2 times, 1 hour every time, obtain extracting solution, extracting solution mistake When being concentrated into 60 DEG C after filter, relative density is 1.44, and Temperature fall cold preservation obtained gen-seng after 48 hours；
(4) preparation a is merged with poria cocos preparation, Semen Euryaless preparation, glycyrrhiza preparation and gen-seng, be sufficiently stirred for all after reclaiming ethanol Even, add water to ormal weight and boil, make every ml medicinal liquid gross weight containing Caulis Seu Folium Euonymi Fortunei be 1-1.5g, obtain after fill described containing Caulis Seu Folium Euonymi Fortunei Anti-fatigue Chinese medicine preparation.
Embodiment 3
Anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei, is made up of the raw material of following parts by weight effective ingredient:
Caulis Seu Folium Euonymi Fortunei 20；
The Radix Astragali 16；
Poria 12；
Semen Euryaless 5；
Radix Glycyrrhizae 9；
Radix Ginseng 5；
The preparation method of the described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is as follows:
(1) decocting of Caulis Seu Folium Euonymi Fortunei and 10 times of ratios of weight and number of the Radix Astragali is boiled 2 times, 2 hours every time, obtain decocting liquid, after decocting liquid filters When being concentrated into 60 DEG C, relative density is 1.44, and the volumetric concentration adding 2 times after Temperature fall is 95% ethanol, stands 48 after stirring evenly Hour obtains preparation a；
(2) Poria, Semen Euryaless and Radix Glycyrrhizae are boiled 2 times with the decocting of 10 times of ratios of weight and number respectively, 2 hours every time, obtain decocting liquid, decoct Liquid filter after when being concentrated into 60 DEG C relative density be 1.44, after Temperature fall cold preservation 48 hours, obtain poria cocos preparation, Semen Euryaless preparation And glycyrrhiza preparation；
(3) Radix Ginseng volumetric concentration be 70% alcohol heating reflux extract 2 times, 2 hours every time, obtain extracting solution, extracting solution mistake When being concentrated into 60 DEG C after filter, relative density is 1.44, and Temperature fall cold preservation obtained gen-seng after 48 hours；
(4) preparation a is merged with poria cocos preparation, Semen Euryaless preparation, glycyrrhiza preparation and gen-seng, be sufficiently stirred for all after reclaiming ethanol Even, add water to ormal weight and boil, make every ml medicinal liquid gross weight containing Caulis Seu Folium Euonymi Fortunei be 1-1.5g, obtain after fill described containing Caulis Seu Folium Euonymi Fortunei Anti-fatigue Chinese medicine preparation.
The following is the present invention contain Caulis Seu Folium Euonymi Fortunei anti-fatigue Chinese medicine preparation pharmacodynamics test:
Take mice 100, each 50 of male and female, it is randomly divided into 5 groups: blank control group, positive drug ginseng royal jelly (10ml/kg) Group, anti-fatigue Chinese medicine preparation (the embodiment 1/ embodiment 2/ embodiment 3) group containing Caulis Seu Folium Euonymi Fortunei, every group of 20 mices, daily respectively Gastric infusion once, continuous 10 days.It is administered latter 1 hour within 10th day, start swimming with a load attached to the body experiment.Bear a heavy burden (about body weight to mice 10% electric fuse) after put into the tank went swimming of about 30 DEG C of water temperature, and record mice and sink to water from starting swimming to being perfectly exhausted Lower 8s can not emerge till time, for muscle power exhaust time.And exhaust swimming test after immediately by mice from water Middle taking-up, after allowing mice to rest 30 minutes, extracts eyeball and takes blood, measure lactic acid and the urine in blood according to clinical reagent cassette method Plain nitrogen content.Test result indicate that, compared with blank control group, in positive drug ginseng royal jelly's group and the resisting fatigue containing Caulis Seu Folium Euonymi Fortunei Medicine preparation group all can extend the swimming time of mice hence it is evident that reducing lactic acid and urea nitrogen content in blood, situation such as following table.
Group Physical exhaustion time (average) Blood lactic acid content Blood urea nitrogen content
Blank control group 48.8s 9.29 mmol/l 24.90 mmol/l
Positive drug ginseng royal jelly's group 65s 6.56 mmol/l 18.33 mmol/l
Embodiment 1 80.1s 4.41mmol/l 11.47 mmol/l
Embodiment 2 96.2s 3.55mmol/l 10.26 mmol/l
Embodiment 3 113.6s 3.01mmol/l 9.88 mmol/l

Claims (1)

1. a kind of anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is it is characterised in that raw material system by following parts by weight effective ingredient Become:
Caulis Seu Folium Euonymi Fortunei 8-20；
Radix Astragali 4-16；
Poria 5-12；
Semen Euryaless 1-5；
Radix Glycyrrhizae 3-9；
Radix Ginseng 1-5；
The preparation method of the described anti-fatigue Chinese medicine preparation containing Caulis Seu Folium Euonymi Fortunei is as follows:
The decocting of Caulis Seu Folium Euonymi Fortunei and 4-10 times of ratio of weight and number of the Radix Astragali is boiled 2 times, each 1-2 hour, obtain decocting liquid, after decocting liquid filters When being concentrated into 60 DEG C, relative density is 1.44, and the volumetric concentration adding 2 times after Temperature fall is 65%-95% ethanol, quiet after stirring evenly Put 48 hours and obtain preparation a；
Poria, Semen Euryaless and Radix Glycyrrhizae are boiled 2 times with the decocting of 4-10 times of ratio of weight and number respectively, each 1-2 hour, obtain decocting liquid, Decocting liquid filter after when being concentrated into 60 DEG C relative density be 1.44, after Temperature fall cold preservation 48 hours, obtain poria cocos preparation, Semen Euryaless system Agent and glycyrrhiza preparation；
Radix Ginseng volumetric concentration is that the alcohol heating reflux of 65%-70% extracts 2 times, and each 1-2 hour obtains extracting solution, extracts When liquid is concentrated into 60 DEG C after filtering, relative density is 1.44, and Temperature fall cold preservation obtained gen-seng after 48 hours；
Preparation a is merged with poria cocos preparation, Semen Euryaless preparation, glycyrrhiza preparation and gen-seng, stir after reclaiming ethanol, Add water to ormal weight to boil, make every ml medicinal liquid gross weight containing Caulis Seu Folium Euonymi Fortunei be 1-1.5g, obtain after fill described containing Caulis Seu Folium Euonymi Fortunei Anti-fatigue Chinese medicine preparation.
CN201610857543.4A 2016-09-28 2016-09-28 Anti-fatigue traditional Chinese medicine preparation containing herba euonymi Pending CN106344654A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1366948A (en) * 2001-01-20 2002-09-04 杨孟君 Nano Fufang Fufangteng preparation medicine and preparation method
CN102085233A (en) * 2009-12-03 2011-06-08 刘欣 Compound fortune euonymus capsule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1366948A (en) * 2001-01-20 2002-09-04 杨孟君 Nano Fufang Fufangteng preparation medicine and preparation method
CN102085233A (en) * 2009-12-03 2011-06-08 刘欣 Compound fortune euonymus capsule

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
全国医药职业技术教育研究会，闫丽霞等: ""扶芳藤"", 《中药制剂技术》 *

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Application publication date: 20170125