CN101549124A - Pharmaceutical composition for nourishing heart, tranquillization, strengthening spleen and benefiting qi and preparation method thereof - Google Patents
Pharmaceutical composition for nourishing heart, tranquillization, strengthening spleen and benefiting qi and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for nourishing heart, tranquillization, strengthening spleen and benefiting qi, and the active ingredients of the composition are prepared by extracting more than ten medicinal materials of pilose Asiabell root, rehmannia root, platycladi seed, membranous milkvetch root, thinleaf milkwort root-bark, amur corktree bark, Szechuan lovage rhizome, common macrocarpium fruit, tuber fleeceflower stem, costustoot, fossilizid (calcined), common anemarrhena rhizome, dwarf lilyturf tuber, sharpleaf galangal fruit and the like. The unique medicinal active ingredients in the pharmaceutical composition have the efficacies of regulating qi, resolving stagnation, eliminating phlegm, inducing resuscitation, nourishing yin and blood, nourishing heart, tranquillization, strengthening spleen and benefiting qi. The pharmaceutical composition is used for treating neurasthenia, such as palpitation, insomnia, multiple dreams, upset, chest tightness, shortness of breath, irritability and anxiety.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to drug regimen of a kind of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI and preparation method thereof.
Technical background
The neurasthenia is mainly weak with brain and somatic function to be feature, and it is easily excited to show as spirit, but fatiguability, and emotion symptom and physiological functions disorder symptoms such as muscular tone pain, sleep disorder such as anxiety, worry, irritability.Symptom is not the disease that is secondary to body or brain, a part that neither other any mental disorders.
The neurasthenia is a kind of modal neurosis.Once there was investigation to find that total prevalence rate is 13.03 in 15～59 years old resident, accounts for 58.7% of whole neurosis cases.Wherein, be engaged in mental work, the people who falls ill such as the teacher of government functionary, universities and secondary specialized schools and student etc. is more.As long as many people even ownly give own diagnosis are once headache occurring, having a sleepless night and thought oneself possibility " neurasthenia ".
The neurasthenia mainly shows as spirit, and excitement is tired especially easily again especially easily: the excitation time patient often loses control of and recalls and associate, it is very sensitive that the sensation aspect also becomes, often keep in dark place, fearness sound, the somebody in addition be afraid of cold, To Be Protected from Heat, a bit stimulate all to be difficult to stand; Can feel mental not enough again but most patients are very fast, feel dizzy, can not beat spirit, absent minded or can not concentrate hypomnesis, even tired from head to foot being short of physical strength lastingly.Secondly, patient always feels to be nervous, and can loosen, and worried especially easily, exciting or fly into a rage somebody even LA depression or hypochondriacal idea occur.In addition, patient muscular tone pain occurs toward the contact meeting, autonomic nervous dysfunction etc., such as the muscle pain that an anxiety is slightly just had a headache or is unable to explain clearly, the somebody also with nervous, perspire, be off one's feed, dyspepsia.Diarrhoea or constipation; Menoxenia can also appear in the aeg, and positive exhibition, seminal emission, premature ejaculation etc. then appear in the Aeg.Aspect sleep, it also is very general various sleep disorder occurring, and such as people's difficulty of sleeping, the light and many nightmare of sleeping is easily waken up with a start, and being difficult to again after waking up, the people sleeps; Even somebody oneself feels " can not sleep "; Somebody's rule disorder of then sleeping sits up at night, and daytime is listless incessantly dozes off.
The neurasthenic cause of disease, thinking at present may be relevant with constraining for a long time of brain hypertonicity or emotion.Research finds that also those show not too optimistic in character, and is responsive suspicious, dependency is strong, and timidity is felt oneself inferior or wilfulness, irritability, the relatively poor people of the ability that contains oneself is ill under various pressure especially easily, and visible patient's characteristics of personality itself also is one of the very important key factor of falling ill.In addition, some environmental factors, such as live or working condition undesirable, excessive crowded, mixed and disorderly, noise, day and night break tour or the like also can become the risk factor of neurasthenia's morbidity.
Suffered from the anxiety that the neurasthenia need not be excessive.But many patients worry that always can't fall asleep, brain can or can not degenerate; Hypomnesis, oneself can or can not become stupidly; Also can become new burden when they seek medical advice and always think when not obtaining satisfactory result everywhere, further increase the weight of the anxiety of spirit and the fatigue of health, thereby make the neurasthenia more serious, this may be the cureless secondary disease of a few patients because of.
Though treating neurasthenic medicine such as barbiturates is at present clinically also using such as secobarbital etc., but because easy addiction, now lacked usefulness, other various anxiolytic drugs are such as stable, estazolam, nitrodiazepam, oxazepan, the high logical sequence of A Pu, roller, Flurazepam.Long-term uses such as sea Lip river god also can produce drug resistance.
The present invention is exactly that the pure Chinese medicine scientific matching of tens flavor flavors is formed, and has the resolving depression of regulating the flow of vital energy, eliminates phlegm for resuscitation, nourishing YIN nourishes blood the effect of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI.Have no addiction simultaneously, drug safety is convenient, and constant product quality is fit to the advantage that patient's selection is taken.
Summary of the invention:
One of purpose of the present invention provides the drug regimen of a kind of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Codonopsis 120-360 part Radix Rehmanniae 100-300 part Semen Platycladi 100-300 part
Radix Astragali 120-360 part Radix Polygalae 100-300 part Cortex Phellodendri 100-300 part
Rhizoma Chuanxiong 120-360 part Fructus Corni 100-300 part YELITENG 60-180 part
Radix Aucklandiae (Radix Vladimiriae) 100-300 part Os Draconis (forging) 60-180 part Rhizoma Anemarrhenae 60-180 part
Radix Ophiopogonis 100-300 part Fructus Alpiniae Oxyphyllae 60-180 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 parts of Semen Platycladi of 240 portions of Radix Rehmanniae of Radix Codonopsis
150 parts of 150 portions of Cortex Phellodendris of 240 parts of Radix Polygalaes of the Radix Astragali
120 parts of 150 parts of YELITENG of 240 parts of Fructus Corni of Rhizoma Chuanxiong
120 parts of 120 parts of Rhizoma Anemarrhenaes of 150 parts of Os Draconis of Radix Aucklandiae (Radix Vladimiriae) (forging)
Radix Ophiopogonis, 150 parts of Fructus Alpiniae Oxyphyllae were 120 parts
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong add 75% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Rehmanniae, Semen Platycladi, Radix Polygalae, Cortex Phellodendri, Fructus Corni, YELITENG, Radix Aucklandiae (Radix Vladimiriae), Os Draconis (forging), the Rhizoma Anemarrhenae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the resolving depression of regulating the flow of vital energy, eliminates phlegm for resuscitation, nourishing YIN nourishes blood the function of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI.Be used for neurasthenia see cardiopalmus, insomnia, dreaminess, vexed uneasiness, uncomfortable in chest, breathe hard, being irritable and getting angry easily, anxiety person.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
150 parts of 150 parts of Semen Platycladi of 240 portions of Radix Rehmanniae of Radix Codonopsis
150 parts of 150 portions of Cortex Phellodendris of 240 parts of Radix Polygalaes of the Radix Astragali
120 parts of 150 parts of YELITENG of 240 parts of Fructus Corni of Rhizoma Chuanxiong
120 parts of 120 parts of Rhizoma Anemarrhenaes of 150 parts of Os Draconis of Radix Aucklandiae (Radix Vladimiriae) (forging)
Radix Ophiopogonis, 150 parts of Fructus Alpiniae Oxyphyllae were 120 parts
2. preparation technology
(1) Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong add 75% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Rehmanniae, Semen Platycladi, Radix Polygalae, Cortex Phellodendri, Fructus Corni, YELITENG, Radix Aucklandiae (Radix Vladimiriae), Os Draconis (forging), the Rhizoma Anemarrhenae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
150 parts of 150 parts of Semen Platycladi of 240 portions of Radix Rehmanniae of Radix Codonopsis
150 parts of 150 portions of Cortex Phellodendris of 240 parts of Radix Polygalaes of the Radix Astragali
120 parts of 150 parts of YELITENG of 240 parts of Fructus Corni of Rhizoma Chuanxiong
120 parts of 120 parts of Rhizoma Anemarrhenaes of 150 parts of Os Draconis of Radix Aucklandiae (Radix Vladimiriae) (forging)
Radix Ophiopogonis, 150 parts of Fructus Alpiniae Oxyphyllae were 120 parts
2. preparation technology
(1) Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong add 75% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Rehmanniae, Semen Platycladi, Radix Polygalae, Cortex Phellodendri, Fructus Corni, YELITENG, Radix Aucklandiae (Radix Vladimiriae), Os Draconis (forging), the Rhizoma Anemarrhenae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
150 parts of 150 parts of Semen Platycladi of 240 portions of Radix Rehmanniae of Radix Codonopsis
150 parts of 150 portions of Cortex Phellodendris of 240 parts of Radix Polygalaes of the Radix Astragali
120 parts of 150 parts of YELITENG of 240 parts of Fructus Corni of Rhizoma Chuanxiong
120 parts of 120 parts of Rhizoma Anemarrhenaes of 150 parts of Os Draconis of Radix Aucklandiae (Radix Vladimiriae) (forging)
Radix Ophiopogonis, 150 parts of Fructus Alpiniae Oxyphyllae were 120 parts
2. preparation technology
(1) Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong add 75% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Rehmanniae, Semen Platycladi, Radix Polygalae, Cortex Phellodendri, Fructus Corni, YELITENG, Radix Aucklandiae (Radix Vladimiriae), Os Draconis (forging), the Rhizoma Anemarrhenae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the drug regimen of a kind of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Codonopsis 120-360 part Radix Rehmanniae 100-300 part Semen Platycladi 100-300 part
Radix Astragali 120-360 part Radix Polygalae 100-300 part Cortex Phellodendri 100-300 part
Rhizoma Chuanxiong 120-360 part Fructus Corni 100-300 part YELITENG 60-180 part
Radix Aucklandiae (Radix Vladimiriae) 100-300 part Os Draconis (forging) 60-180 part Rhizoma Anemarrhenae 60-180 part
Radix Ophiopogonis 100-300 part Fructus Alpiniae Oxyphyllae 60-180 part.
2, the drug regimen of a kind of heart tonifying and tranquilizing according to claim 1, invigorating the spleen and benefiting QI is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 parts of Semen Platycladi of 240 portions of Radix Rehmanniae of Radix Codonopsis
150 parts of 150 portions of Cortex Phellodendris of 240 parts of Radix Polygalaes of the Radix Astragali
120 parts of 150 parts of YELITENG of 240 parts of Fructus Corni of Rhizoma Chuanxiong
120 parts of 120 parts of Rhizoma Anemarrhenaes of 150 parts of Os Draconis of Radix Aucklandiae (Radix Vladimiriae) (forging)
Radix Ophiopogonis, 150 parts of Fructus Alpiniae Oxyphyllae were 120 parts.
3, according to the drug regimen of the described a kind of heart tonifying and tranquilizing of claim 1-2, invigorating the spleen and benefiting QI, it is characterized in that adopting following method to make:
(1) Radix Codonopsis, the Radix Astragali, Rhizoma Chuanxiong add 75% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Rehmanniae, Semen Platycladi, Radix Polygalae, Cortex Phellodendri, Fructus Corni, YELITENG, Radix Aucklandiae (Radix Vladimiriae), Os Draconis (forging), the Rhizoma Anemarrhenae, Radix Ophiopogonis, Fructus Alpiniae Oxyphyllae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the drug regimen of any one described a kind of heart tonifying and tranquilizing, invigorating the spleen and benefiting QI among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the drug regimen of the described a kind of heart tonifying and tranquilizing of claim 3-4, invigorating the spleen and benefiting QI.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101034264A CN101549124A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition for nourishing heart, tranquillization, strengthening spleen and benefiting qi and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101034264A CN101549124A (en) | 2008-04-03 | 2008-04-03 | Pharmaceutical composition for nourishing heart, tranquillization, strengthening spleen and benefiting qi and preparation method thereof |
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| CN101549124A true CN101549124A (en) | 2009-10-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873943A (en) * | 2015-06-09 | 2015-09-02 | 徐艳 | Pharmaceutic preparation for treating anxiety |
| CN105831751A (en) * | 2016-04-18 | 2016-08-10 | 重庆三峡医药高等专科学校 | Health-care traditional Chinese medicine composition with effects of tonifying qi and strengthening brain and preparation method and using method thereof |
| CN107468975A (en) * | 2017-08-11 | 2017-12-15 | 孟广千 | Chinese medicine composition for bushing treatment syndrome of spleen deficiency disease |
-
2008
- 2008-04-03 CN CNA2008101034264A patent/CN101549124A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873943A (en) * | 2015-06-09 | 2015-09-02 | 徐艳 | Pharmaceutic preparation for treating anxiety |
| CN105831751A (en) * | 2016-04-18 | 2016-08-10 | 重庆三峡医药高等专科学校 | Health-care traditional Chinese medicine composition with effects of tonifying qi and strengthening brain and preparation method and using method thereof |
| CN105831751B (en) * | 2016-04-18 | 2020-01-03 | 重庆三峡医药高等专科学校 | Traditional Chinese medicine health-care composition for tonifying qi and strengthening brain, preparation method and use method thereof |
| CN107468975A (en) * | 2017-08-11 | 2017-12-15 | 孟广千 | Chinese medicine composition for bushing treatment syndrome of spleen deficiency disease |
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Open date: 20091007 |