CN106334180A - Chinese and Western medicine oral preparation for treating type II diabetes - Google Patents

Chinese and Western medicine oral preparation for treating type II diabetes Download PDF

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CN106334180A
CN106334180A CN201610703004.5A CN201610703004A CN106334180A CN 106334180 A CN106334180 A CN 106334180A CN 201610703004 A CN201610703004 A CN 201610703004A CN 106334180 A CN106334180 A CN 106334180A
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powder
western medicine
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vitamin
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吕欢
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Abstract

The invention discloses a Chinese and Western medicine oral preparation for treating type II diabetes, the Chinese and Western medicine oral preparation comprises the following components: rose of Jericho, Vitis labrusca, multiflora rose, angle snail, all-grass of Anderson's Edelweiss, seedling of Calystegia sepium, Mustela putorius protein water soluble powder, Leucocyanidin, vitexin, Astragalin, cryptoxanthin, scopoletin, eoixol, taxol, spinach extract, fenofibrate, acetazolamide, oxaflozane hydrochloride, fiber powder and compound vitamins; by reasonable proportion of a variety of Western medicine effective ingredients and traditional Chinese medicine ingredients, blood sugar can be effectively reduced, the Chinese and Western medicine oral preparation also has the effect of promoting blood circulation to remove meridian obstruction, nourishing yin and clearing heat, relieving swelling and dispersing blood stasis, and anti-inflammatory and antibacterial effect, by regulating of the blood sugar, control of infection, and activating and dredging of collaterals, life of patients with the type II diabetes can be improved, and complications of the type II diabetes can be prevented and reduced.

Description

A kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM
Technical field
The present invention relates to diabetic technical field, it is specifically related to a kind of Chinese medicine and western medicine treating patients with type Ⅰ DM and is administered orally Preparation.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycemia, hyperglycemia be then due to defect of insulin secretion or Its biological agent is impaired, or both have concurrently and cause, and the diagnosis of diabetes is typically not difficult, and fasting glucose is more than or equal to 7.0 mmoles You/liter, or two hours blood glucoses can be made a definite diagnosis more than or equal to 11.1 mM/ls after the meal.Diabetes are divided into i type and ii type glycosuria Disease, feed is excessive, and it is the topmost environmental factorss of ii patients with type Ⅰ DM that physical exertion reduces the obesity leading to, and hypertension, blood fat are different The factor such as normal also can increase risk, and has obvious family history, and most of ii patients with type Ⅰ DM are in 30 years old with sequela.ii In patients with type Ⅰ DM a part of patient based on insulin resistant, how fat patient is, because of insulin resistant, under insulin sensitivity Fall, in blood, insulin increases to compensate its insulin resistant, but for the hyperglycemia of relative patient, insulin secretion is still relatively not Foot, such patient's early symptom is inconspicuous, only slightly weak, thirsty, often can occur before clarifying a diagnosis big blood vessel and Microvascular complication.The long-standing hyperglycemia of diabetes, not only can bring injury to patient's body and mind, and its cause various The chronic lesion of tissue and dysfunction are so that diabetic complication is up to kind more than 100, and the irreversibility of its complication can be given Patient brings bigger injury, therefore the prevention of diabetic complication is also the key for the treatment of diabetes.Ii patients with type Ⅰ DM is also named into People's onset diabetes, how 35-40 year sequela, account for diabeticss more than 90%, produce in ii patients with type Ⅰ DM ward mate's body The ability of raw insulin not completely loses, and the insulin in the patient having even produces excessively, but the action effect of insulin But have a greatly reduced quality, insulin therefore in the patient is a kind of shortage relatively.Internal pancreas can be stimulated by some oral drugs The secretion of island element.
The treatment of ii patients with type Ⅰ DM and its complication should reduce diabetes and its simultaneously to put prevention first, by glycemic control Send out the sickness rate of disease, patient also should coordinate diet and exercise.Treatment to ii patients with type Ⅰ DM is stimulated with oral hypoglycemic drug at present Based on the secretion of internal insulin, but such oral hypoglycemic drug dependency is big, and the side effect that body is brought is not also little, and simultaneously The outbreak of diabetic complication can not be controlled well, so the treatment to ii patients with type Ⅰ DM and its complication had both needed to control blood Sugar, needs to dredge from inside, the meridian dredging again, removes blood stasis, will improve symptom and conditioning combines and could fundamentally treat ii type Diabetes simultaneously control its complication, here it is the present invention is to be studied.
Content of the invention
The technical scheme is that, a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM, are by following weight portion One-tenth be grouped into: demutation grass 36-62 part, white tripe 33-59 part, white residual flower 31-56 part, angle spiral shell operculum 28-52 part, Herba Leontopodii andersonii 26-49 part, Caulis et Folium Calystegiae sepii 25-45 part, Mustela eversmanni lesson. albumen water soluble powder 23-43 part, leucocianidol 20-38 part, vitexin 17-36 part, Astragalin 15-33 part, cryptoxanthine 13-30 part, scopoletin 11-27 part, Coixol 8-24 part, taxol 6-21 part, Herba Spinaciae Extract 5-17 part, fenofibrate 4-13 part, acetazolamide 2-10 part, Oxaflozane Hydrochloride 1.5-7.5 part, fiber powder 4-16 Part, compound vitamin 0.015-0.037 part.
Further, the preparation method of described Mustela eversmanni lesson. albumen water soluble powder is: takes Mustela eversmanni lesson. to remove internal organs and osteoderm for medicine Green meat, is carried out with high-speed tissue mashing machine after cleaning up smashing process to pieces so as to cell is completely severed, is easy to extract, Add the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, add mixed enzyme, adjust ph value in 4-6, hydrolysis temperature is set At 5-9 DEG C, enzymolysis time is 11-13h, is brought rapidly up enzyme denaturing and lives, gained enzymolysis solution is through gel chromatography post separation after the completion of enzymolysis Filter, gained filtrate is concentrated into the concentrated solution that relative density is 1.03, then carries out vacuum dehydrating at lower temperature, obtains Mustela eversmanni lesson. albumen water-soluble Powder, has promoting blood circulation to remove obstruction in the collateral, adjusts nerve metabolism, the effect of tonification salubrity, described mixed enzyme is trypsin and pancreatic lipase Ratio with mass ratio as 5:3 mixes.
Further, the extracting method of described Spinach extract is: take fresh Herba Spinaciae, rubbed with juice extractor, then It is placed in decoction 1.5h in 10-12 times amount water, decoction process remains slight boiling condition, filters in backward filtering residue and adds 6-8 times Amount decocting boils 40min, filters out supernatant, merges gained supernatant twice, is concentrated into 2 times amount volumes, adds ethanol solution, stirs Mix, stand 5h, after sedimentation completely, centrifugation, take supernatant, be concentrated into the extractum of proportion d=1.16, be spray-dried, that is, obtain Spinach extract.Described ethanol solution be 3-5 times amount mass concentration be 62-68%, temperature control at 25-30 DEG C, this model The precipitate with ethanol enclosing, up to maximum extracted rate, contains chromium and a kind of para-insulin sample material in the leaf of spinach, and its effect is with insulin very Similar, blood glucose can be made to keep stable, and its extract also has tonifying blood and arresting bleeding, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing is put down Liver, digestant effect.
Further, the preparation method of described fiber powder is: by sub kernel, wheat bran and bran after remove impurity process, mill Become fine powder, then the fiber powder that fine powder is obtained after micronizing, it contains abundant cellulose and can reduce insulin requirement amount, control Make into metabolism after the meal, thus reaching the effect adjusting blood glucose.
Further, described compound vitamin vitamin p, vitamin b1, vitamin b12, vitamin c are with 6:4:5:3's The mixture that mass ratio mixes, vitamin p can prevent and treat the retinopathy that diabetes cause, vitamin b1, vitamin b12 Can reduce and alleviate the diabetic neuropathy such as peripheral neuritiss, vitamin c can reduce the infection that diabetic complication causes and send out Raw rate, this several vitamins synergy can enhancing body resistivity, reduce diabetic infection occurrence probability, diabetes-alleviating Complication pathological changes.
A kind of preparation method of the Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM is:
(1) take Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, entered with high-speed tissue mashing machine after cleaning up Row smashs process to pieces so as to cell is completely severed, and is easy to extract, adds the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, Add mixed enzyme, adjust ph value in 4-6, hydrolysis temperature is set at 5-9 DEG C, enzymolysis time is 11-13h, rapid after the completion of enzymolysis Intensification enzyme denaturing is lived, and through gel chromatography column separating and filtering, gained filtrate is concentrated into the concentration that relative density is 1.03 to gained enzymolysis solution Liquid, then carry out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder, standby, there is promoting blood circulation to remove obstruction in the collateral, adjust nerve metabolism, tonification The effect of salubrity, described mixed enzyme mixes for the trypsin and pancreatic lipase ratio with mass ratio as 5:3；
(2) take fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 10-12 times amount water, decoction process begins Keep slight boiling condition eventually, add 6-8 times amount decocting in the backward filtering residue of filtration and boil 40min, filter out supernatant, merge institute twice Obtain supernatant, be concentrated into 2 times amount volumes, add ethanol solution, stir, stand 5h, after sedimentation is complete, centrifugation, take supernatant, It is concentrated into the extractum of proportion d=1.16, is spray-dried, that is, obtains Spinach extract, standby, described ethanol solution is 3-5 times amount Mass concentration be 62-68%, at 25-30 DEG C, the precipitate with ethanol of this scope, up to maximum extracted rate, contains in the leaf of spinach temperature control There are chromium and a kind of para-insulin sample material, its effect is closely similar with insulin, blood glucose can be made to keep stable, and its extract is also There is tonifying blood and arresting bleeding, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；
(3) by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then fine powder is obtained after micronizing The fiber powder arriving, standby, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus reaching Adjust the effect of blood glucose；
(4) weigh that demutation is careless according to described weight proportion, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, clearly It is placed in after wash clean in dehydrator and dries, setting drying temperature is 51-61 DEG C, and drying time is 10min, then be ground into thick Powder, the coarse powder and mass concentration ethanol solution for 65-73% is pressed the solid-liquid ratio mixing of 1:13, adds in ultrasonic extractor Row supersound extraction 50min, gained extracting solution, with silicon dioxide as fixing phase, is purified using silica gel column chromatography, the eluting obtaining Liquid concentrating under reduced pressure is condensed into extractum after reclaiming ethanol, is spray-dried, excessively 120 mesh sieves, and prepared extract powder is standby；
(5) by the leucocianidol of described composition by weight, vitexin, astragalin, cryptoxanthine, scopoletin, Coixol, Taxol, fenofibrate, acetazolamide, Oxaflozane Hydrochloride, compound vitamin are pulverized with super micron mill after mixing and are mixed Close medicated powder, standby；
(6) by Mustela eversmanni lesson. albumen water soluble powder prepared to the step (1) of described weight portion and step (3) and fiber powder 5 times amount Aquation open, then by the step (2) of described weight portion be obtained Spinach extract and step (4) be obtained extract powder, step (5) Prepared mixed powder adds, and adds the emulsifying agent of mixed solution 3.5% weight portion, and mechanical agitation uniformly, seals after sterilizing Storage, that is, obtain the Chinese medicine and western medicine oral formulations of described treatment patients with type Ⅰ DM.
The invention has the beneficial effects as follows: the treatment of diabetes not only will slow down increasing of the state of an illness by controlling blood glucose, more To coordinate antiinflammatory, promoting blood circulation to remove obstruction in the collateral while controlling blood glucose, the drug effect of nourishing YIN and clearing away heat carrys out therapeutic alliance, and the present invention has to multiple Effect composition carries out rational proportion, not only can effectively reduce blood glucose, also have promoting blood circulation to remove obstruction in the collateral, nourishing YIN and clearing away heat, detumescence, antibacterial The effect of antiinflammatory, by adjusting blood glucose, infection control, the meridian dredging alive is sick come the life and reduction diabetes to improve diabetic The outbreak of people's complication.Chinese medicine demutation is careless, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, Mustela eversmanni lesson. albumen are water-soluble Powder, Spinach extract have functions that to adjust blood glucose, promoting blood circulation to remove obstruction in the collateral, nourishing YIN and clearing away heat, removing blood stasis to reduce swelling, vitexin, scopoletin connection With having the effect of antimicrobial antiphlogistic, Coixol, fenofibrate synergy have the effect adjusting blood glucose balance, Bai Shiche for cooperation Centautin, astragalin, cryptoxanthine, taxol, acetazolamide, Oxaflozane Hydrochloride synergy have auxiliary adjustment blood glucose, in advance Effect that is anti-and reducing diabetic complication, fiber powder, compound vitamin can improve body immunity, strengthen patient to slight illness Resistance.
Specific embodiment
Embodiment 1:
A kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM, are to be composed of the following components in parts by weight: demutation grass 36 Part, 33 parts of white tripe, 31 parts of white residual flower, 28 parts of angle spiral shell operculum, 26 parts of Herba Leontopodii andersonii, 25 parts of Caulis et Folium Calystegiae sepii, Mustela eversmanni lesson. albumen water soluble powder 23 Part, 20 parts of leucocianidol, 17 parts of vitexin, 15 parts of astragalin, 13 parts of cryptoxanthine, 11 parts of scopoletin, 8 parts of Coixol, 6 parts of taxol, 5 parts of Spinach extract, 4 parts of fenofibrate, 2 parts of acetazolamide, 1.5 parts of Oxaflozane Hydrochloride, 4 parts of fiber powder, 0.015 part of compound vitamin.
Wherein, the preparation method of described Mustela eversmanni lesson. albumen water soluble powder is: takes Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal Green meat, is carried out with high-speed tissue mashing machine after cleaning up smashing process to pieces so as to cell is completely severed, is easy to extract, adds 7 The sodium citrate buffer of times amount, is placed in enzymatic vessel, adds mixed enzyme, adjusts ph value 4, setting hydrolysis temperature at 5 DEG C, enzyme The solution time is 11h, is brought rapidly up enzyme denaturing and lives, gained enzymolysis solution is through gel chromatography column separating and filtering, gained filtrate after the completion of enzymolysis It is concentrated into the concentrated solution that relative density is 1.03, then carries out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder, there is promoting blood circulation logical Network, adjusts nerve metabolism, the effect of tonification salubrity, and described mixed enzyme is trypsin and pancreatic lipase with mass ratio as 5:3 Ratio mix；The extracting method of described Spinach extract is: takes fresh Herba Spinaciae, is rubbed with juice extractor, then puts Decoct 1.5h in 10 times amount water, decoction process remains slight boiling condition, adds 6 times amount decoctings and boil in the backward filtering residue of filtration 40min, filters out supernatant, merges gained supernatant twice, is concentrated into 2 times amount volumes, adds ethanol solution, stirring, standing 5h, after sedimentation completely, centrifugation, take supernatant, be concentrated into the extractum of proportion d=1.16, be spray-dried, that is, obtain Herba Spinaciae and extract Thing.Described ethanol solution is the mass concentration of 3 times amount is 62%, and, at 25 DEG C, the precipitate with ethanol of this scope is up to maximum for temperature control Extraction ratio, contains chromium and a kind of para-insulin sample material in the leaf of spinach, its effect is closely similar with insulin, and blood glucose can be made to keep Stable, and its extract also has tonifying blood and arresting bleeding, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；Institute The preparation method stating fiber powder is: by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then by fine powder through super The fiber powder obtaining after Crushing of Ultrafine, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus Reach the effect adjusting blood glucose；Described compound vitamin vitamin p, vitamin b1, vitamin b12, vitamin c are with 6:4:5:3 The mixture that mixes of mass ratio, vitamin p can prevent and treat the retinopathy that diabetes cause, vitamin b1, vitamin B12 can reduce and alleviate the diabetic neuropathy such as peripheral neuritiss, and vitamin c can reduce the infection that diabetic complication causes Incidence rate, this several vitamins synergy can enhancing body resistivity, reduce diabetic infection occurrence probability, alleviate glycosuria Sick complication pathological changes.
A kind of preparation method of the Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM is:
(1) take Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, entered with high-speed tissue mashing machine after cleaning up Row smashs process to pieces so as to cell is completely severed, and is easy to extract, adds the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, Add mixed enzyme, adjust ph value 4, hydrolysis temperature is set at 5 DEG C, enzymolysis time is 11h, is brought rapidly up enzyme denaturing after the completion of enzymolysis Live, through gel chromatography column separating and filtering, gained filtrate is concentrated into the concentrated solution that relative density is 1.03 to gained enzymolysis solution, then carries out Vacuum dehydrating at lower temperature, obtains Mustela eversmanni lesson. albumen water soluble powder, standby, has promoting blood circulation to remove obstruction in the collateral, adjusts nerve metabolism, the work of tonification salubrity With described mixed enzyme mixes for the trypsin and pancreatic lipase ratio with mass ratio as 5:3；
(2) take fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 10 times amount water, decoction process is all the time Keep slight boiling condition, add 6 times amount decoctings in the backward filtering residue of filtration and boil 40min, filter out supernatant, merging is twice on gained Clear liquid, is concentrated into 2 times amount volumes, adds ethanol solution, stirs, stands 5h, after sedimentation completely, centrifugation, and take supernatant, concentration To the extractum of proportion d=1.16, it is spray-dried, that is, obtains Spinach extract, standby, described ethanol solution is the quality of 3 times amount Concentration is 62%, and at 25 DEG C, the precipitate with ethanol of this scope, up to maximum extracted rate, contains chromium and a species to temperature control in the leaf of spinach Insulin-like material, its effect is closely similar with insulin, and blood glucose can be made to keep stable, and its extract also has and only enriches blood Blood, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；
(3) by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then fine powder is obtained after micronizing The fiber powder arriving, standby, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus reaching Adjust the effect of blood glucose；
(4) weigh that demutation is careless according to described weight proportion, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, clearly It is placed in after wash clean in dehydrator and dries, setting drying temperature is 51 DEG C, and drying time is 10min, then is ground into coarse powder, The ethanol solution that coarse powder and mass concentration are 65% is mixed by the solid-liquid ratio of 1:13, carries out ultrasonic in addition ultrasonic extractor Extract 50min, with silicon dioxide as fixing phase, using silica gel column chromatography purification, the eluent obtaining reduces pressure gained extracting solution It is condensed into extractum after concentration and recovery ethanol, is spray-dried, excessively 120 mesh sieves, prepared extract powder, standby；
(5) by the leucocianidol of described composition by weight, vitexin, astragalin, cryptoxanthine, scopoletin, Coixol, Taxol, fenofibrate, acetazolamide, Oxaflozane Hydrochloride, compound vitamin are pulverized with super micron mill after mixing and are mixed Close medicated powder, standby；
(6) by Mustela eversmanni lesson. albumen water soluble powder prepared to the step (1) of described weight portion and step (3) and fiber powder 5 times amount Aquation open, then by the step (2) of described weight portion be obtained Spinach extract and step (4) be obtained extract powder, step (5) Prepared mixed powder adds, and adds the emulsifying agent of mixed solution 3.5% weight portion, and mechanical agitation uniformly, seals after sterilizing Storage, that is, obtain the Chinese medicine and western medicine oral formulations of described treatment patients with type Ⅰ DM.
Embodiment 2:
A kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM, are to be composed of the following components in parts by weight: demutation grass 49 Part, 46 parts of white tripe, 43.5 parts of white residual flower, 40 parts of angle spiral shell operculum, 37.5 parts of Herba Leontopodii andersonii, 35 parts of Caulis et Folium Calystegiae sepii, Mustela eversmanni lesson. albumen are water-soluble 33 parts of powder, 29 parts of leucocianidol, 26.5 parts of vitexin, 24 parts of astragalin, 21.5 parts of cryptoxanthine, 19 parts of scopoletin, the heart of a lotus seed 16 parts of Job's tears element, 13.5 parts of taxol, 11 parts of Spinach extract, 8.5 parts of fenofibrate, 6 parts of acetazolamide, Oxaflozane Hydrochloride 4.5 parts, 10 parts of fiber powder, 0.026 part of compound vitamin.
Wherein, the preparation method of described Mustela eversmanni lesson. albumen water soluble powder is: takes Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal Green meat, is carried out with high-speed tissue mashing machine after cleaning up smashing process to pieces so as to cell is completely severed, is easy to extract, adds 7 The sodium citrate buffer of times amount, is placed in enzymatic vessel, adds mixed enzyme, adjusts ph value 5, setting hydrolysis temperature at 7 DEG C, enzyme The solution time is 12h, is brought rapidly up enzyme denaturing and lives, gained enzymolysis solution is through gel chromatography column separating and filtering, gained filtrate after the completion of enzymolysis It is concentrated into the concentrated solution that relative density is 1.03, then carries out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder, there is promoting blood circulation logical Network, adjusts nerve metabolism, the effect of tonification salubrity, and described mixed enzyme is trypsin and pancreatic lipase with mass ratio as 5:3 Ratio mix；The extracting method of described Spinach extract is: takes fresh Herba Spinaciae, is rubbed with juice extractor, then puts Decoct 1.5h in 11 times amount water, decoction process remains slight boiling condition, adds 7 times amount decoctings and boil in the backward filtering residue of filtration 40min, filters out supernatant, merges gained supernatant twice, is concentrated into 2 times amount volumes, adds ethanol solution, stirring, standing 5h, after sedimentation completely, centrifugation, take supernatant, be concentrated into the extractum of proportion d=1.16, be spray-dried, that is, obtain Herba Spinaciae and extract Thing.Described ethanol solution is the mass concentration of 4 times amount is 65%, and, at 27.5 DEG C, the precipitate with ethanol of this scope is up to for temperature control Big extraction ratio, contains chromium and a kind of para-insulin sample material in the leaf of spinach, its effect is closely similar with insulin, and blood glucose can be made to protect It is fixed to keep steady, and its extract also has tonifying blood and arresting bleeding, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect； The preparation method of described fiber powder is: by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then by fine powder warp The fiber powder obtaining after micronizing, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, from And reach the effect adjusting blood glucose；Described compound vitamin vitamin p, vitamin b1, vitamin b12, vitamin c are with 6:4:5: The mixture that 3 mass ratio mixes, vitamin p can prevent and treat the retinopathy that diabetes cause, vitamin b1, vitamin B12 can reduce and alleviate the diabetic neuropathy such as peripheral neuritiss, and vitamin c can reduce the infection that diabetic complication causes Incidence rate, this several vitamins synergy can enhancing body resistivity, reduce diabetic infection occurrence probability, alleviate glycosuria Sick complication pathological changes.
A kind of preparation method of the Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM is:
(1) take Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, entered with high-speed tissue mashing machine after cleaning up Row smashs process to pieces so as to cell is completely severed, and is easy to extract, adds the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, Add mixed enzyme, adjust ph value 5, hydrolysis temperature is set at 7 DEG C, enzymolysis time is 12h, is brought rapidly up enzyme denaturing after the completion of enzymolysis Live, through gel chromatography column separating and filtering, gained filtrate is concentrated into the concentrated solution that relative density is 1.03 to gained enzymolysis solution, then carries out Vacuum dehydrating at lower temperature, obtains Mustela eversmanni lesson. albumen water soluble powder, standby, has promoting blood circulation to remove obstruction in the collateral, adjusts nerve metabolism, the work of tonification salubrity With described mixed enzyme mixes for the trypsin and pancreatic lipase ratio with mass ratio as 5:3；
(2) take fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 11 times amount water, decoction process is all the time Keep slight boiling condition, add 7 times amount decoctings in the backward filtering residue of filtration and boil 40min, filter out supernatant, merging is twice on gained Clear liquid, is concentrated into 2 times amount volumes, adds ethanol solution, stirs, stands 5h, after sedimentation completely, centrifugation, and take supernatant, concentration To the extractum of proportion d=1.16, it is spray-dried, that is, obtains Spinach extract, standby, described ethanol solution is the quality of 4 times amount Concentration is 65%, and at 27.5 DEG C, the precipitate with ethanol of this scope, up to maximum extracted rate, contains chromium and one kind to temperature control in the leaf of spinach Para-insulin sample material, its effect is closely similar with insulin, and blood glucose can be made to keep stable, and its extract also has and only enriches blood Blood, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；
(3) by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then fine powder is obtained after micronizing The fiber powder arriving, standby, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus reaching Adjust the effect of blood glucose；
(4) weigh that demutation is careless according to described weight proportion, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, clearly It is placed in after wash clean in dehydrator and dries, setting drying temperature is 56 DEG C, and drying time is 10min, then is ground into coarse powder, The ethanol solution that coarse powder and mass concentration are 69% is mixed by the solid-liquid ratio of 1:13, carries out ultrasonic in addition ultrasonic extractor Extract 50min, with silicon dioxide as fixing phase, using silica gel column chromatography purification, the eluent obtaining reduces pressure gained extracting solution It is condensed into extractum after concentration and recovery ethanol, is spray-dried, excessively 120 mesh sieves, prepared extract powder, standby；
(5) by the leucocianidol of described composition by weight, vitexin, astragalin, cryptoxanthine, scopoletin, Coixol, Taxol, fenofibrate, acetazolamide, Oxaflozane Hydrochloride, compound vitamin are pulverized with super micron mill after mixing and are mixed Close medicated powder, standby；
(6) by Mustela eversmanni lesson. albumen water soluble powder prepared to the step (1) of described weight portion and step (3) and fiber powder 5 times amount Aquation open, then by the step (2) of described weight portion be obtained Spinach extract and step (4) be obtained extract powder, step (5) Prepared mixed powder adds, and adds the emulsifying agent of mixed solution 3.5% weight portion, and mechanical agitation uniformly, seals after sterilizing Storage, that is, obtain the Chinese medicine and western medicine oral formulations of described treatment patients with type Ⅰ DM.
Embodiment 3:
A kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM, are to be composed of the following components in parts by weight: demutation grass 62 Part, 59 parts of white tripe, 56 parts of white residual flower, 52 parts of angle spiral shell operculum, 49 parts of Herba Leontopodii andersonii, 45 parts of Caulis et Folium Calystegiae sepii, Mustela eversmanni lesson. albumen water soluble powder 43 Part, 38 parts of leucocianidol, 36 parts of vitexin, 33 parts of astragalin, 30 parts of cryptoxanthine, 27 parts of scopoletin, 24 parts of Coixol, 21 parts of taxol, 17 parts of Spinach extract, 13 parts of fenofibrate, 10 parts of acetazolamide, 7.5 parts of Oxaflozane Hydrochloride, fiber powder 16 parts, 0.037 part of compound vitamin.
Wherein, the preparation method of described Mustela eversmanni lesson. albumen water soluble powder is: takes Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal Green meat, is carried out with high-speed tissue mashing machine after cleaning up smashing process to pieces so as to cell is completely severed, is easy to extract, adds 7 The sodium citrate buffer of times amount, is placed in enzymatic vessel, adds mixed enzyme, adjusts ph value 6, setting hydrolysis temperature at 9 DEG C, enzyme The solution time is 13h, is brought rapidly up enzyme denaturing and lives, gained enzymolysis solution is through gel chromatography column separating and filtering, gained filtrate after the completion of enzymolysis It is concentrated into the concentrated solution that relative density is 1.03, then carries out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder, there is promoting blood circulation logical Network, adjusts nerve metabolism, the effect of tonification salubrity, and described mixed enzyme is trypsin and pancreatic lipase with mass ratio as 5:3 Ratio mix；The extracting method of described Spinach extract is: takes fresh Herba Spinaciae, is rubbed with juice extractor, then puts Decoct 1.5h in 12 times amount water, decoction process remains slight boiling condition, adds 8 times amount decoctings and boil in the backward filtering residue of filtration 40min, filters out supernatant, merges gained supernatant twice, is concentrated into 2 times amount volumes, adds ethanol solution, stirring, standing 5h, after sedimentation completely, centrifugation, take supernatant, be concentrated into the extractum of proportion d=1.16, be spray-dried, that is, obtain Herba Spinaciae and extract Thing.Described ethanol solution is the mass concentration of 5 times amount is 68%, and, at 30 DEG C, the precipitate with ethanol of this scope is up to maximum for temperature control Extraction ratio, contains chromium and a kind of para-insulin sample material in the leaf of spinach, its effect is closely similar with insulin, and blood glucose can be made to keep Stable, and its extract also has tonifying blood and arresting bleeding, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；Institute The preparation method stating fiber powder is: by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then by fine powder through super The fiber powder obtaining after Crushing of Ultrafine, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus Reach the effect adjusting blood glucose；Described compound vitamin vitamin p, vitamin b1, vitamin b12, vitamin c are with 6:4:5:3 The mixture that mixes of mass ratio, vitamin p can prevent and treat the retinopathy that diabetes cause, vitamin b1, vitamin B12 can reduce and alleviate the diabetic neuropathy such as peripheral neuritiss, and vitamin c can reduce the infection that diabetic complication causes Incidence rate, this several vitamins synergy can enhancing body resistivity, reduce diabetic infection occurrence probability, alleviate glycosuria Sick complication pathological changes.
A kind of preparation method of the Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM is:
(1) take Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, entered with high-speed tissue mashing machine after cleaning up Row smashs process to pieces so as to cell is completely severed, and is easy to extract, adds the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, Add mixed enzyme, adjust ph value 6, hydrolysis temperature is set at 9 DEG C, enzymolysis time is 13h, is brought rapidly up enzyme denaturing after the completion of enzymolysis Live, through gel chromatography column separating and filtering, gained filtrate is concentrated into the concentrated solution that relative density is 1.03 to gained enzymolysis solution, then carries out Vacuum dehydrating at lower temperature, obtains Mustela eversmanni lesson. albumen water soluble powder, standby, has promoting blood circulation to remove obstruction in the collateral, adjusts nerve metabolism, the work of tonification salubrity With described mixed enzyme mixes for the trypsin and pancreatic lipase ratio with mass ratio as 5:3；
(2) take fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 12 times amount water, decoction process is all the time Keep slight boiling condition, add 8 times amount decoctings in the backward filtering residue of filtration and boil 40min, filter out supernatant, merging is twice on gained Clear liquid, is concentrated into 2 times amount volumes, adds ethanol solution, stirs, stands 5h, after sedimentation completely, centrifugation, and take supernatant, concentration To the extractum of proportion d=1.16, it is spray-dried, that is, obtains Spinach extract, standby, described ethanol solution is the quality of 5 times amount Concentration is 68%, and at 30 DEG C, the precipitate with ethanol of this scope, up to maximum extracted rate, contains chromium and a species to temperature control in the leaf of spinach Insulin-like material, its effect is closely similar with insulin, and blood glucose can be made to keep stable, and its extract also has and only enriches blood Blood, sharp the five internal organs, promoting blood circulation, intestine moistening of quenching the thirst, YIN nourishing suppressing the hyperactive liver, digestant effect；
(3) by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then fine powder is obtained after micronizing The fiber powder arriving, standby, it contains abundant cellulose and can reduce insulin requirement amount, controls into metabolism after the meal, thus reaching Adjust the effect of blood glucose；
(4) weigh that demutation is careless according to described weight proportion, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, clearly It is placed in after wash clean in dehydrator and dries, setting drying temperature is 61 DEG C, and drying time is 10min, then is ground into coarse powder, The ethanol solution that coarse powder and mass concentration are 73% is mixed by the solid-liquid ratio of 1:13, carries out ultrasonic in addition ultrasonic extractor Extract 50min, with silicon dioxide as fixing phase, using silica gel column chromatography purification, the eluent obtaining reduces pressure gained extracting solution It is condensed into extractum after concentration and recovery ethanol, is spray-dried, excessively 120 mesh sieves, prepared extract powder, standby；
(5) by the leucocianidol of described composition by weight, vitexin, astragalin, cryptoxanthine, scopoletin, Coixol, Taxol, fenofibrate, acetazolamide, Oxaflozane Hydrochloride, compound vitamin are pulverized with super micron mill after mixing and are mixed Close medicated powder, standby；
(6) by Mustela eversmanni lesson. albumen water soluble powder prepared to the step (1) of described weight portion and step (3) and fiber powder 5 times amount Aquation open, then by the step (2) of described weight portion be obtained Spinach extract and step (4) be obtained extract powder, step (5) Prepared mixed powder adds, and adds the emulsifying agent of mixed solution 3.5% weight portion, and mechanical agitation uniformly, seals after sterilizing Storage, that is, obtain the Chinese medicine and western medicine oral formulations of described treatment patients with type Ⅰ DM.
Application in treatment patients with type Ⅰ DM for the Chinese-western medicine preparation of the present invention:
1st, animal model preparation:
From individual variation less test rat 180, wherein 120 rats are carried out with 10 days normal nursings and detects it Every sign, normal in the case of make it 10 hours on an empty stomach, by the streptozotocin aseptic sodium citrate buffer of 0.1mol/l Fresh becomes 2% solution, adjusts ph to 5, bacteria filter filtration sterilization, disposably injects preparation by 55mg/kg body weight tail vein Good streptozotocin solution, in 20 hours, blood glucose is more than or equal to 16.7mmol/l, stablizes 7 days then rat diabetes modeling one-tenth Work(, is classified as testing a group, experiment b group, experiment c group, experiment d group, every group 30, remaining 60 rats be divided into matched group and Untreated fish group.
2nd, medication:
Feed normal saline to untreated fish group rat daily, control rats feed current therapies patients with type Ⅰ DM Medicine, experiment a group, experiment b group, experiment c group rat feed in the embodiment of the present invention 1, embodiment 2 and embodiment 3 preparation respectively Western medicine oral formulations, experiment d group rat feed the 5 times amount embodiment of the present invention 2 prepare Chinese medicine and western medicine oral formulations, continuous 15 days, The blood glucose situation of observed and recorded rat.
3rd, test data foundation: be according to criterion empty stomach whole blood blood glucose: 3.9-6.1mmol/l, mild diabetes: 7.0-8.4mmol/l, medium diabetes mellitus: 8.4-11.1mmol/l, severe diabetes: greater than 11.1mmol/l.
4th, test data statistics and result: d group rat tested by solution plane, and finds no other organs damage that any medication causes Wound is it is seen that toxic and side effects of the present invention are little.
Blood sugar monitoring is as follows:
Group Case load Blood glucose normal rat number Blood glucose has declined number of rats Hyperglycemic rat number
Experiment a group 30 17 9 4
Experiment b group 30 22 7 1
Experiment c group 30 18 10 2
Experiment d group 30 20 7 3
Matched group 30 10 9 11
Untreated fish group 30 30 0 0
As can be seen from the above table, the Chinese-western medicine preparation of present invention preparation has good hypoglycemic effect, and toxic and side effects are little, Can be used for control and the treatment of patients with type Ⅰ DM and its complication.
The clinical experiment of the present invention:
1st, case-data: inventor have collected diabetes mellitus type 240, between age 40-70 year, its fasting glucose All >=7.8mmol/l, is classified as experimental group, experimental group, experimental group and matched group, every group of 60 people.
2nd, test method:
Take the embodiment of the present invention 1, embodiment 2, embodiment 3 to respectively experimental group, experimental group, experimental group patient The Chinese medicine and western medicine oral formulations of preparation, twice daily, take after the meal, and 2 weeks is a course for the treatment of, serve on 3 courses for the treatment of, the course for the treatment of such as matched group Take the medicine of current therapies patients with type Ⅰ DM.
3rd, criterion:
The normal index criterion of blood glucose: fasting glucose 3.9-6.1mmol/l, 2 hours is after the meal 3.9-7.8mmol/ L, the blood glucose empty stomach of diabeticss is more than 7.8mmol/l, is more than 11.1mmol/l within 2 hours after the meal.
4th, criterion of therapeutical effect:
Effective: patient blood glucose recovers normal, complication symptom be improved significantly or do not recur again；
Effective: patient blood glucose recovers normal, complication is eased or recurrent number subtracts；
Invalid: patient blood glucose does not decline, clinical symptoms are also no improved or are had and increase trend.
3.2 therapeutic outcomes:
Group Case load Effective Effectively Invalid Effective percentage %
Experiment a group 60 42 14 4 93.3
Experiment b group 60 45 13 2 96.6
Experiment c group 60 44 14 2 96.6
Matched group 60 31 16 13 78.3
Can be seen that the present invention by upper table statistical data and prepare Chinese-western medicine preparation has good curative effect to patients with type Ⅰ DM, no Only can effectively reduce blood glucose, can also control and improve the complication symptom of diabetic, and total effective rate reaches 93.3% More than, and toxic and side effects are little.
4th, model case
Case one: Zhao so-and-so, man, 65 years old, detect fasting glucose 8.31mmol/l, two hours blood glucose 12.35mmol/ after the meal L, and have complication diabetic ophthalmopathy, after two courses for the treatment of of Chinese medicine and western medicine oral formulations using the embodiment of the present invention 1 preparation, blood glucose is just Often, complication symptom is eased, and continues to take 2 two courses for the treatment of, symptom is wholly absent, and be careful in one's diet control, does not recur again.
Case two: Zhai, man, 58 years old, diabetic history 7 years, main suit is thirsty, polydipsia, weak, detection fasting glucose 9.4mmol/l, after two courses for the treatment of of Chinese medicine and western medicine oral formulations using the embodiment of the present invention 2 preparation, blood glucose declines, and clinical symptoms obtain To improving, after 4 courses for the treatment of of medication, symptom disappears, and blood glucose is normal, and be careful in one's diet control, does not recur again.
Case three: money, female, 55 years old, diabetic history 10 years, and have diabetic peripheral vasculopathy, take medicine always but normal Have repeatedly, after 1 course for the treatment of of Chinese medicine and western medicine oral formulations using the embodiment of the present invention 3 preparation, blood glucose declines, blood glucose after 3 courses for the treatment of Recover normal, clinical symptom disappearance, be careful in one's diet control, does not recur again.
Although the present invention is described and illustrated with reference to its specific embodiments, it will be appreciated by those skilled in the art that Without departing from the spirit and scope of the present invention it can be variously modified, change and replace.For example, due to quilt The change of the responding ability of people for the treatment of particular condition, the effective dose beyond the preferred dose being explained as above may be suitable for.With Sample ground it was observed that pharmacology's response may basis and particular active compounds selected by relying on or with the presence or absence of pharmaceutical carrier and Preparation type and mode of administration used and become, according to the purpose of the present invention and practice be contemplated to this kind of performance of expected change in result or Difference.Therefore, the invention is intended to only being limited by the scope of following claims and these claim should be in rational degree Explain as broadly as possible.

Claims (7)

1. a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM are it is characterised in that be to be composed of the following components in parts by weight: Demutation grass 36-62 part, white tripe 33-59 part, white residual flower 31-56 part, angle spiral shell operculum 28-52 part, Herba Leontopodii andersonii 26-49 part, Flos Calystegiae sepii Seedling 25-45 part, Mustela eversmanni lesson. albumen water soluble powder 23-43 part, leucocianidol 20-38 part, vitexin 17-36 part, astragalin 15-33 Part, cryptoxanthine 13-30 part, scopoletin 11-27 part, Coixol 8-24 part, taxol 6-21 part, Spinach extract 5-17 part, Fenofibrate 4-13 part, acetazolamide 2-10 part, Oxaflozane Hydrochloride 1.5-7.5 part, fiber powder 4-16 part, compound vitamin 0.015-0.037 part.
2. as claimed in claim 1 a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM it is characterised in that described Chinese mugwort The preparation method of brave albumen water soluble powder is: takes Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, with height after cleaning up Fast tissue mashing machine carries out smashing process to pieces so as to cell is completely severed, and is easy to extract, adds the sodium citrate buffer of 7 times amount, It is placed in enzymatic vessel, adds mixed enzyme, adjust ph value in 4-6, hydrolysis temperature is set at 5-9 DEG C, enzymolysis time is 11-13h, enzyme It is brought rapidly up enzyme denaturing after the completion of solution to live, gained enzymolysis solution is concentrated into relative density through gel chromatography column separating and filtering, gained filtrate Concentrated solution for 1.03, then carry out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder.
3. as claimed in claim 1 a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM it is characterised in that described spinach The extracting method of dish extract is: takes fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 10-12 times amount water, Decoction process remains slight boiling condition, adds 6-8 times amount decocting and boils 40min, filter out supernatant in the backward filtering residue of filtration, Merge gained supernatant twice, be concentrated into 2 times amount volumes, add ethanol solution, stir, stand 5h, after sedimentation completely, from The heart, takes supernatant, is concentrated into the extractum of proportion d=1.16, is spray-dried, that is, obtains Spinach extract.
4. as claimed in claim 3 a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM it is characterised in that described ethanol Solution is the mass concentration of 3-5 times amount is 62-68%, and reaction temperature controls at 25-30 DEG C.
5. as claimed in claim 1 a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM it is characterised in that described fiber The preparation method of powder is: by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then by fine powder through micronizing The fiber powder obtaining afterwards.
6. as claimed in claim 1 a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM it is characterised in that described compound Vitamin vitamin p, vitamin b1, vitamin b12, the mixture of vitamin c.
7. a kind of Chinese medicine and western medicine oral formulations treating patients with type Ⅰ DM as described in claim 1-5 any one, its feature exists In being, its preparation method is:
(1) take Mustela eversmanni lesson. to remove internal organs and osteoderm for medicinal green meat, smash with high-speed tissue mashing machine after cleaning up Broken process, so as to cell is completely severed, is easy to extract, is added the sodium citrate buffer of 7 times amount, be placed in enzymatic vessel, add Mixed enzyme, adjusts ph value in 4-6, arranges hydrolysis temperature at 5-9 DEG C, enzymolysis time is 11-13h, is brought rapidly up after the completion of enzymolysis Enzyme denaturing is lived, and through gel chromatography column separating and filtering, gained filtrate is concentrated into the concentrated solution that relative density is 1.03 to gained enzymolysis solution, then Carry out vacuum dehydrating at lower temperature, obtain Mustela eversmanni lesson. albumen water soluble powder, standby；
(2) take fresh Herba Spinaciae, rubbed with juice extractor, then be placed in decoction 1.5h in 10-12 times amount water, decoction process is protected all the time Hold slight boiling condition, add 6-8 times amount decocting in the backward filtering residue of filtration and boil 40min, filter out supernatant, merging is twice on gained Clear liquid, is concentrated into 2 times amount volumes, adds ethanol solution, stirs, stands 5h, after sedimentation completely, centrifugation, and take supernatant, concentration To the extractum of proportion d=1.16, it is spray-dried, that is, obtains Spinach extract, standby；
(3) by sub kernel, wheat bran and bran after remove impurity process, wear into fine powder, then fine powder is obtained after micronizing Fiber powder, standby；
(4) weigh that demutation is careless according to described weight proportion, white tripe, white residual flower, angle spiral shell operculum, Herba Leontopodii andersonii, Caulis et Folium Calystegiae sepii, cleaning is dry It is placed in after net in dehydrator and dries, setting drying temperature is 51-61 DEG C, and drying time is 10min, then is ground into coarse powder, The coarse powder and mass concentration ethanol solution for 65-73% is pressed the solid-liquid ratio mixing of 1:13, add in ultrasonic extractor and carry out Supersound extraction 50min, gained extracting solution, with silicon dioxide as fixing phase, is purified using silica gel column chromatography, the eluent obtaining Concentrating under reduced pressure is condensed into extractum after reclaiming ethanol, is spray-dried, excessively 120 mesh sieves, and prepared extract powder is standby；
(5) by the leucocianidol of described composition by weight, vitexin, astragalin, cryptoxanthine, scopoletin, Coixol, Ramulus et folium taxi cuspidatae Phenol, fenofibrate, acetazolamide, Oxaflozane Hydrochloride, compound vitamin are pulverized with super micron mill after mixing and are obtained mixing medicine Powder, standby；
(6) the Mustela eversmanni lesson. albumen water soluble powder step (1) of described weight portion and step (3) being obtained and the water of fiber powder 5 times amount Melt, then by extract powder prepared to the prepared Spinach extract of the step (2) of described weight portion and step (4), step (5) is obtained Mixed powder add, add the emulsifying agent of mixed solution 3.5% weight portion, mechanical agitation uniformly, sealed storage after sterilizing, Obtain the Chinese medicine and western medicine oral formulations of described treatment patients with type Ⅰ DM.
CN201610703004.5A 2016-08-22 2016-08-22 Chinese and Western medicine oral preparation for treating type II diabetes Pending CN106334180A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017178456A1 (en) * 2016-04-11 2017-10-19 Greenaltech, S.L Uses of a carotenoid in the treatment or prevention of stress induced conditions
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CN107441478A (en) * 2017-10-11 2017-12-08 苏州和必尔斯电子科技有限公司 A kind of pharmaceutical composition for treating chronic enterogastritis and preparation method thereof

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Application publication date: 20170118