CN106333998A - Bacteriostatic nasal-spray honeysuckle fluid - Google Patents

Bacteriostatic nasal-spray honeysuckle fluid Download PDF

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Publication number
CN106333998A
CN106333998A CN201610917006.4A CN201610917006A CN106333998A CN 106333998 A CN106333998 A CN 106333998A CN 201610917006 A CN201610917006 A CN 201610917006A CN 106333998 A CN106333998 A CN 106333998A
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radix
flos lonicerae
nasal
radix angelicae
spray
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CN201610917006.4A
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曹越凡
王敏
刘燕清
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Jining Shu Kang Biotechnology Co Ltd
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Jining Shu Kang Biotechnology Co Ltd
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Priority to CN201610917006.4A priority Critical patent/CN106333998A/en
Publication of CN106333998A publication Critical patent/CN106333998A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a bacteriostatic nasal-spray honeysuckle fluid. The bacteriostatic nasal-spray honeysuckle fluid is prepared from, 16-32 g of honeysuckle, 8-12 g of radix angelica sinensis, 10-15 g of ligusticum chuanxiong hort, 10-15 g of astragalusmembranaceus, 18-22 g of radix scutellariae, 8-12 g of angelica dahurica, 8-12 g of magnolia flower and 150ml of vitamin E. The bacteriostatic nasal-spray honeysuckle fluid is bacteriostatic and clean and is suitable for daily health care and nursing of nasal cavity discomfort such as nasal obstruction, nasal itching and nasal mucosa function depression.

Description

Flos Lonicerae sprays nose antibacterial liquid
Technical field
The present invention relates to one kind is used for treating cacorhinia, more particularly, to a kind of Flos Lonicerae sprays nose antibacterial liquid.
Background technology
Weather turns cold, adds air pollution, dust storm, densely populated etc., vulnerable people just becomes easy catching a cold crowd, and Flu is easy to cause rhinitis occurred frequently.Because acute rhinitises are similar with cold symptoms, it is all nasal obstruction, headache, sneeze, rhinorrhea, has People will wrong by rhinitis when flu is controlled.Eat coldrex, but do not improved, recurrent exerbation, until having changed into chronic rhinitiss.Somebody Though knowing that oneself obtained rhinitis, thinking " do not delay to eat not delay and drink ", being minor illness.In fact, rhinitis morbidity clinical symptoms are different, Except rhinocnesmus, sneeze, time one length also results in headache, dizziness, hypomnesis etc., in addition understand concurrent emphysema, pulmonary heart disease, The serious diseases such as asthma.The prolonged and repeated outbreak of sinusitis is not got timely medical treatment again, and inflammation will diffuse to adjacent organss, group Knit.The possibility suffering from nasopharyngeal carcinoma also can be increased simultaneously.
Content of the invention
The technical problem to be solved is: provides one kind and is used for treating cacorhinia, antibacterial, cleaning is it is adaptable to nose The uncomfortable daily health caring nursing of nasal cavity such as plug, rhinocnesmus, nasal mucosa function be impaired.
A kind of Flos Lonicerae sprays nose antibacterial liquid, is made up of following crude drug: Flos Lonicerae 16-32g, Radix Angelicae Sinensis 8-12g, Rhizoma Chuanxiong 10-15g, Radix Astragali 10-15g, Radix Scutellariae 18-22g, Radix Angelicae Dahuricae 8-12g, Flos Magnoliae 8-12g, vitamin e150ml.
Preferably, it is made up of following crude drug: Flos Lonicerae 30g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 12g, Radix Astragali 12g, Radix Scutellariae 20g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, vitamin e150ml.
The preparation method that described Flos Lonicerae sprays nose antibacterial liquid is: take each crude drug, mixing, and pulverize 200 mesh sieves, add life Reason saline 200ml, vitamin e150ml, mix, obtain final product.Using rear enclosed, lucifuge is put the shady and cool place of drying and is preserved, it is to avoid sunlight is straight Penetrate.
The property of medicine of Chinese medicine used by the present invention is as follows:
Flos Lonicerae: Flos Lonicerae is cold in nature, sweet in the mouth, enter lung, the heart, stomach, have functions that heat-clearing and toxic substances removing, antiinflammatory, qi-restoratives treat wind, cure mainly Disease, warm disease heating under distension, the disease such as heat toxin large carbuncle and tumor.It makees thirsty, hyperhidrosis unhappiness, enteritis, bacterium for dizzy dizzy, xerostomia Dysentery, measles, pneumonia, encephalitis b, epidemic encephalitiss, acute mastitiss, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, the parotid gland The diseases such as inflammation, suppurative tonsillitiss all have certain curative effect.
Radix Angelicae Sinensis: nature and flavor: sweet, pungent, warm return through: Return liver, the heart, spleen channel.Indication: enrich blood;Promoting blood circulation;Menstruction regulating and pain relieving;Moisturize Laxation.The all cards of main blood deficiency;Menoxenia;Amenorrhea;Dysmenorrhea;Lump in the abdomen knot is poly-;Metrorrhagia;Asthenia cold abdominalgia;Flaccidity syndrome and arthralgia syndrome;Numbness of the skin;Dryness of the intestine Dyschezia;Weight after bloody dysentery;Ulcer sores;Injury from falling down.
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Return through: enter liver, gallbladder meridian.Indication: activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control Air-cooled headache rotation is dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, Closed dysmenorrhea, abdominal mass is suffered from abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Astragali: nature and flavor: sweet, tepor.Return through: return lung, spleen, liver and kidney channel.The Radix Astragali has benefiting QI for strengthening the superficies, arrest sweating admittedly take off, torr sore life The effect of flesh, inducing diuresis to remove edema.For treating treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult Burst, bursts for a long time and does not holds back, blood deficiency and yellow complexion, Heat Diabetes, chronic nephritiss, albuminuria, diabetes etc..Radix Astragali Preparata invigorating middle warmer and replenishing QI, life is with admittedly Table torr sore.
Radix Scutellariae: nature and flavor: bitter in the mouth, cold in nature.Return through: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, pathogenic fire purging solution Poison, hemostasis, antiabortive.Cure mainly: for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, hyperpyrexia is tired of Yearningly, blood-head tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
The Radix Angelicae Dahuricae: nature and flavor: pungent, temperature.Return through: enter lung, spleen, stomach.Indication: wind-dispelling, dampness, detumescence, pain relieving.Control head Bitterly, supraorbital bone pain, toothache, nasal sinusitis, cold-dampness stomachache, intestines wind anal fistula, leucorrhea with red and white discharge, ulcer sores, skin is dry itches, scabies.
Flos Magnoliae: abnormal smells from the patient is pungent, warm, nontoxic.Cure mainly: nasal sinusitis, nasal obstruction.Ground into powder with Flos Magnoliae, plus Moschus is a little, is dipped into nose with Bulbus Allii Fistulosi In, take effect several times.
The present invention Flos Lonicerae spray nose antibacterial liquid, antibacterial, cleaning it is adaptable to the nasal cavity such as nasal obstruction, rhinocnesmus, rhinocnesmus discomfort day Often caring.Take this product spray nose, 2 times a day.
Points for attention: 1, avoid contact with eyes.2nd, can use after shaking up if any slight precipitation, not affect quality.3rd, this product Not yet find untoward reaction, allergic phenomena such as occurs and disables immediately, after deactivation, symptom disappears.4th, child must be under recognizing monitoring Use.5th, please by this product be positioned over child getting in contact less than place.6th, anemia of pregnant woman uses with caution.
The Flos Lonicerae spray nose antibacterial liquid of the present invention, is capable of the nasal cavity of dredge blockage, so that the blood vessel of hyperemia, the mucosa of swelling is received Contracting, unobstructed;The sensitivity of nerve can be reduced, have desensitization to allergia nose's mucosa;So that secreting gland liquid is reduced, suppress nose Transmucosal hamartoplasia, helps the regulation of nasal cavity temperature, humidity, convergence and protection nasal mucosa, nutrient vessel and nerve and epithelium Cell etc. is organized.The inflammation of each sinus cavities that gasify, makes nasal cavity recover dedusting, degermation;A surname adjusts lung qi, clears up lung-heat, has greatly gas Breath mixes well nose from logical reason, so that cacorhinia is cured at short notice.The Flos Lonicerae spray nose antibacterial liquid of the present invention, can be effectively improved and play spray Sneeze, have a stuffy nose, the symptom such as rhinorrhea, rhinocnesmus, there are no obvious adverse reaction over the course for the treatment of, safely and effectively.
Specific embodiment
With reference to embodiment, the present invention is further illustrated.
Embodiment 1 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 30g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 12g, Radix Astragali 12g, Radix Scutellariae 20g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, vitamin e150ml.
Preparation method is: take each crude drug, mixing, and pulverize 200 mesh sieves, add normal saline 200ml, vitamin E150ml, mixes, obtains final product.Using rear enclosed, lucifuge is put the shady and cool place of drying and is preserved, it is to avoid direct sunlight.
The Flos Lonicerae spray nose antibacterial liquid of the present invention, antibacterial, cleaning is it is adaptable to the nose such as nasal obstruction, rhinocnesmus, nasal mucosa function be impaired The uncomfortable daily health caring nursing in chamber.Take this product spray nose, 2 times a day.
Embodiment 2 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 16g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Astragali 15g, Radix Scutellariae 18g, Radix Angelicae Dahuricae 12g, Flos Magnoliae 12g, vitamin e150ml.
Preparation method is with embodiment 1.
Embodiment 3 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 32g, Radix Angelicae Sinensis 8g, Rhizoma Chuanxiong 15g, Radix Astragali 10g, Radix Scutellariae 22g, Radix Angelicae Dahuricae 12g, Flos Magnoliae 8g, vitamin e150ml.
Preparation method is with embodiment 1.
Embodiment 4 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 31g, Radix Angelicae Sinensis 11g, Rhizoma Chuanxiong 11g, Radix Astragali 11g, Radix Scutellariae 22g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, vitamin e150ml.
Preparation method is with embodiment 1.
Embodiment 5 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 29g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 12g, Radix Astragali 10g, Radix Scutellariae 18g, Radix Angelicae Dahuricae 8g, Flos Magnoliae 8g, vitamin e150ml.
Preparation method is with embodiment 1.
Embodiment 6 preparation Flos Lonicerae spray nose antibacterial liquid
Formula is: Flos Lonicerae 30.01g, Radix Angelicae Sinensis 10.05g, Rhizoma Chuanxiong 12.15g, Radix Astragali 12.32g, Radix Scutellariae 20.42g, the Radix Angelicae Dahuricae 10.51g, Flos Magnoliae 10.23g, vitamin e150ml.
Preparation method is with embodiment 1.
Clinical data:
Patient data: suffer from rhinitis degree identical patient, man 200, female 200 for 400;25~58 years old age, average 35 years old; The course of disease 0.5~6.0 year.It is randomly divided into two groups, treatment group 200, matched group 200, two groups of no difference of science of statistics.
Therapeutic modality: treatment group adopts medicine (prepared by the embodiment 1) treatment of the present invention, takes this product spray nose, 2 times a day i.e. Can.Matched group adopts Budesonide Nasal Spray to treat, and is produced by Astrazeneca AB of Sweden, specification: 64 μ g/ sprays, and 120 sprays/ ?.Daily 2 times, each 1 time sooner or later, every time under each nostril spray 1.After treatment one month, observe statistics curative effect.
The standard of curative effect evaluation:
Cure: the symptom such as nasal obstruction, rhinorrhea, rhinocnesmus, sneeze disappears, and no recurs within more than 3 months.
Effective: the attack times of the symptom such as nasal obstruction, rhinorrhea, rhinocnesmus, sneeze significantly reduce, and attack degree is substantially shown in Effect, but all do not disappear.
Invalid: symptom, sign slightly mitigate or the person of not being any change.
Therapeutic outcome: after treating one month, in 200 patients for the treatment of group, cure 148, effective 42, invalid 10, Cure rate 74%, total effective rate 95%.Adverse reactions people is there are no in therapeutic process.In 200 patients of matched group, cure 40, Effective 131, invalid 29, cure rate 20%, total effective rate 85.5%.Adverse reactions people is there are no in therapeutic process.
Conclusion: the medicine of the present invention, sneeze can be effectively improved, have a stuffy nose, stay the symptoms such as nasal mucus, rhinocnesmus, can be used for treating Allergic rhinitises, there are no obvious adverse reaction, safely and effectively over the course for the treatment of.
The specific embodiment of the present invention is not construed as limiting the invention, the analog structure of every employing present invention and change Change, all within the scope of the present invention.

Claims (7)

1. a kind of Flos Lonicerae spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: Flos Lonicerae 16-32g, Radix Angelicae Sinensis 8-12g, Rhizoma Chuanxiong 10-15g, Radix Astragali 10-15g, Radix Scutellariae 18-22g, Radix Angelicae Dahuricae 8-12g, Flos Magnoliae 8-12g, vitamin e150ml.
2. Flos Lonicerae according to claim 1 spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: gold Flos Lonicerae 30g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 12g, Radix Astragali 12g, Radix Scutellariae 20g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, vitamin e150ml.
3. Flos Lonicerae according to claim 1 spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: gold Flos Lonicerae 16g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 10g, Radix Astragali 15g, Radix Scutellariae 18g, Radix Angelicae Dahuricae 12g, Flos Magnoliae 12g, vitamin e150ml.
4. Flos Lonicerae according to claim 1 spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: gold Flos Lonicerae 32g, Radix Angelicae Sinensis 8g, Rhizoma Chuanxiong 15g, Radix Astragali 10g, Radix Scutellariae 22g, Radix Angelicae Dahuricae 12g, Flos Magnoliae 8g, vitamin e150ml.
5. Flos Lonicerae according to claim 1 spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: gold Flos Lonicerae 31g, Radix Angelicae Sinensis 11g, Rhizoma Chuanxiong 11g, Radix Astragali 11g, Radix Scutellariae 22g, Radix Angelicae Dahuricae 10g, Flos Magnoliae 10g, vitamin e150ml.
6. Flos Lonicerae according to claim 1 spray nose antibacterial liquid it is characterised in that: be made up of following crude drug: gold Flos Lonicerae 29g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 12g, Radix Astragali 10g, Radix Scutellariae 18g, Radix Angelicae Dahuricae 8g, Flos Magnoliae 8g, vitamin e150ml.
7. Flos Lonicerae according to any one of claim 1~6 spray nose antibacterial liquid preparation method it is characterised in that: take Each crude drug, mixing, pulverized 200 mesh sieves, added normal saline 200ml, vitamin e150ml, and mixed, obtain final product.
CN201610917006.4A 2016-10-21 2016-10-21 Bacteriostatic nasal-spray honeysuckle fluid Pending CN106333998A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1135910A (en) * 1996-01-30 1996-11-20 赵胜堂 Capsule of Bidoukang
CN1355044A (en) * 2001-12-10 2002-06-26 赵胜堂 Medicine for treating nasosinusitis
CN1491698A (en) * 2003-09-03 2004-04-28 邢吉民 Medicine for treating rhinitis
CN101322759A (en) * 2008-07-07 2008-12-17 张景峰 Medicament for treating coryza and preparation thereof
CN103405504A (en) * 2013-09-02 2013-11-27 天津生机集团股份有限公司 Traditional Chinese medicine granules for treating respiratory bovine infectious rhinotracheitis and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1135910A (en) * 1996-01-30 1996-11-20 赵胜堂 Capsule of Bidoukang
CN1355044A (en) * 2001-12-10 2002-06-26 赵胜堂 Medicine for treating nasosinusitis
CN1491698A (en) * 2003-09-03 2004-04-28 邢吉民 Medicine for treating rhinitis
CN101322759A (en) * 2008-07-07 2008-12-17 张景峰 Medicament for treating coryza and preparation thereof
CN103405504A (en) * 2013-09-02 2013-11-27 天津生机集团股份有限公司 Traditional Chinese medicine granules for treating respiratory bovine infectious rhinotracheitis and preparation method thereof

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Application publication date: 20170118