CN106309558A - 一种鼻腔喷雾剂 - Google Patents
一种鼻腔喷雾剂 Download PDFInfo
- Publication number
- CN106309558A CN106309558A CN201610834185.5A CN201610834185A CN106309558A CN 106309558 A CN106309558 A CN 106309558A CN 201610834185 A CN201610834185 A CN 201610834185A CN 106309558 A CN106309558 A CN 106309558A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- raw material
- weight
- weight portions
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007922 nasal spray Substances 0.000 title claims abstract description 17
- 229940097496 nasal spray Drugs 0.000 title abstract 4
- 241000628997 Flos Species 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000008104 plant cellulose Substances 0.000 claims abstract description 11
- 239000013535 sea water Substances 0.000 claims abstract description 10
- 229940041616 menthol Drugs 0.000 claims abstract 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract 3
- 239000002994 raw material Substances 0.000 claims description 68
- 239000001913 cellulose Substances 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 241000272814 Anser sp. Species 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 2
- 240000002853 Nelumbo nucifera Species 0.000 claims 2
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 claims 1
- 239000005844 Thymol Substances 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229930003836 cresol Natural products 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 menthol ester Chemical class 0.000 claims 1
- 229940100630 metacresol Drugs 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 238000007127 saponification reaction Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 229960000790 thymol Drugs 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 abstract description 17
- 206010039085 Rhinitis allergic Diseases 0.000 abstract description 9
- 201000010105 allergic rhinitis Diseases 0.000 abstract description 9
- 201000009890 sinusitis Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 5
- 201000009151 chronic rhinitis Diseases 0.000 abstract description 4
- 230000001969 hypertrophic effect Effects 0.000 abstract description 4
- 210000004877 mucosa Anatomy 0.000 abstract description 4
- 206010028748 Nasal obstruction Diseases 0.000 abstract description 3
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 230000001154 acute effect Effects 0.000 abstract description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 3
- 241001633683 Centipeda <firmicute> Species 0.000 abstract 2
- 241001529821 Agastache Species 0.000 abstract 1
- 241000218378 Magnolia Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 241001162994 Rugosus Species 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 241000246044 Sophora flavescens Species 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 206010028735 Nasal congestion Diseases 0.000 description 4
- 239000013566 allergen Substances 0.000 description 4
- 208000001840 Dandruff Diseases 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000002850 nasal mucosa Anatomy 0.000 description 3
- 210000001331 nose Anatomy 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000008283 Atrophic Rhinitis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000709687 Coxsackievirus Species 0.000 description 1
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 description 1
- 206010052137 Ear discomfort Diseases 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010039088 Rhinitis atrophic Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- CKMXBZGNNVIXHC-UHFFFAOYSA-L ammonium magnesium phosphate hexahydrate Chemical compound [NH4+].O.O.O.O.O.O.[Mg+2].[O-]P([O-])([O-])=O CKMXBZGNNVIXHC-UHFFFAOYSA-L 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 239000007923 nasal drop Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000000253 proventriculus Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 201000002859 sleep apnea Diseases 0.000 description 1
- 229910052567 struvite Inorganic materials 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
- C07C29/19—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings
- C07C29/20—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings in a non-condensed rings substituted with hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/88—Separation; Purification; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification of at least one compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明提供一种鼻腔喷雾剂，由以下重量份的原料构成：鹅不食草8‑10重量份，辛夷花6‑7重量份，薄荷脑12‑15重量份，海水34‑51重量份，植物纤维素5‑7重量份，等渗调节剂1‑2重量份，黄芩1‑2重量份，苦参6‑8重量份，薄荷5‑8重量份，藿香5‑7重量份；与现有技术相比，本发明具有如下的有益效果：鹅不食草可治鼻塞不通，鼻渊流涕，薄荷脑在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用，辛夷花可治疗急性慢性鼻炎、过敏性鼻炎、肥厚性鼻炎、鼻窦炎、副鼻窦炎等，配合其他药用辅料，有疗效突出、治愈率高、简便廉验、易于临床推广的优点。
Description
技术领域
本发明是一种鼻腔喷雾剂，属于医用制剂领域。
背景技术
鼻是人体最重要的嗅觉器官，感知外界的同时也更易受到外来有害物质或致敏性物质的侵扰，从而引发鼻充血、过敏性鼻炎等常见的疾病。鼻腔由于其特殊的生理结构，一旦发生鼻充血、鼻炎等疾病会影响其他器官的正常工作，如鼻充血可能会造成耳部不适、干扰听觉、影响发音，严重的鼻充血可能会造成失眠，甚至睡眠呼吸暂停。
鼻炎即鼻腔炎性疾病，指的是鼻腔粘膜和粘膜下组织的炎症，其表现多种多样。一般是由病毒、细菌、真菌、变应原、各种理化因子及全身性病变引起的鼻腔黏膜炎症。鼻炎根据划分角度的不同，可以分为很多种 ：从鼻腔粘膜的病理学改变来说，有慢性单纯性鼻炎、慢性肥厚性鼻炎、干酪性鼻炎、萎缩性鼻炎等 ；从发病的急缓及病程的长短来说，可分为急性鼻炎和慢性鼻炎。从发病的病因来说，有变态反应性鼻炎 ( 亦即过敏性鼻炎 )、药物性鼻炎等。但不管是什么原因引起的鼻炎，主要病理改变是鼻腔黏膜充血，肿胀、渗出 ；增生、萎缩、或坏死等，其中病毒感染是首因，在病毒感染的基础上继发细菌感染，已知 100 多种病毒可引起本病，最常见的鼻病毒，冠状病毒，柯萨奇病毒及黏液和副黏液病毒等，病毒传播主要为经过呼吸到吸入。
变态反应性鼻炎是指鼻黏膜极易感染性，易感染性的产生源于抗原物质的经常刺激，变应性鼻炎患者黏膜中上述细胞数量不但高于正常人，且有较强释放化学介质的能力抗原物质，刺激性机体产生 LgE 抗体的抗原物质的变应原，再次进入鼻黏膜，使与相应的LgE 结合而引起的变态反应。研究表明引起本病的变应原的主要方式为吸入性类。吸入性变应原为 ：①花粉，②真菌，③屋尘螨，④动物皮屑，⑤室内尘土，鼻黏膜损伤后，遇到空气中微生物及过敏原就会产生鼻窦炎，过敏性鼻炎，长时间得不到恢复就会演变为慢性炎症。
传统中医治疗炎症性鼻通气障碍使用的药物外治疗法不外有中药滴鼻剂、中药吹鼻剂，虽有一定疗效，但治愈率和显效率均欠满意，同时局部刺激性大，副反应多，不宜为患者接受，而且药物在局部难达充分和均匀，小儿腺样体部位隐深，更是药物难达病所，且作用时间短，极大影响了药物疗效。
发明内容
针对现有技术存在的不足，本发明目的是提供一种鼻腔喷雾剂，以解决上述背景技术中提出的问题。
为了实现上述目的，本发明是通过如下的技术方案来实现：一种鼻腔喷雾剂，由以下重量份的原料构成：鹅不食草8-10重量份，辛夷花6-7重量份，薄荷脑12-15重量份，海水34-51重量份，植物纤维素5-7重量份，等渗调节剂1-2重量份，黄芩1-2重量份，苦参6-8重量份，薄荷5-8重量份，藿香5-7重量份。
进一步地，所述植物纤维素由麦麸与无机酸捣成浆状，制成α-纤维素，再经处理使纤维素作部分解聚，然后再除去非结晶部分并提纯而得。
进一步地，取叶片楔状倒披针形，长7-20mm，宽3-5mm的鹅不食草，研磨粉碎至200目，制成原料中的鹅不食草。
进一步地，取辛夷花放入容器中，加入两倍于辛夷花重量的水，形成溶液，浸泡30-50min，利用闪急蒸馏的方法将上述溶液提纯，制成原料中的辛夷花。
进一步地，每100重量份的原料中含有鹅不食草10重量份，每100重量份的原料中含有辛夷花6重量份，每100重量份的原料中含有薄荷脑15重量份，每100重量份的原料中含有海水40重量份，每100重量份的原料中含有植物纤维素5重量份，每100重量份的原料中含有等渗调节剂2重量份，每100重量份的原料中含有黄芩1重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷8重量份，每100重量份的原料中含有藿香7重量份。
进一步地，每100重量份的原料中含有鹅不食草8重量份，每100重量份的原料中含有辛夷花7重量份，每100重量份的原料中含有薄荷脑12重量份，每100重量份的原料中含有海水46重量份，每100重量份的原料中含有植物纤维素7重量份，每100重量份的原料中含有等渗调节剂1重量份，每100重量份的原料中含有黄芩2重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷6重量份，每100重量份的原料中含有藿香5重量份。
本发明的有益效果：本发明的一种鼻腔喷雾剂，鹅不食草可治鼻塞不通，鼻渊流涕，薄荷脑在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用，辛夷花可治疗急性慢性鼻炎、过敏性鼻炎、肥厚性鼻炎、鼻窦炎、副鼻窦炎等，配合其他药用辅料，有疗效突出、治愈率高、简便廉验、易于临床推广的优点。
具体实施方式
为使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施方式，进一步阐述本发明。
本发明提供一种技术方案：一种鼻腔喷雾剂，由以下重量份的原料构成：鹅不食草8-10重量份，辛夷花6-7重量份，薄荷脑12-15重量份，海水34-51重量份，植物纤维素5-7重量份，等渗调节剂1-2重量份，黄芩1-2重量份，苦参6-8重量份，薄荷5-8重量份，藿香5-7重量份。
植物纤维素由麦麸与无机酸捣成浆状，制成α-纤维素，再经处理使纤维素作部分解聚，然后再除去非结晶部分并提纯而得。
取叶片楔状倒披针形，长7-20mm，宽3-5mm的鹅不食草，研磨粉碎至200目，制成原料中的鹅不食草。
取辛夷花放入容器中，加入两倍于辛夷花重量的水，形成溶液，浸泡30-50min，利用闪急蒸馏的方法将上述溶液提纯，制成原料中的辛夷花。
做为本发明的一个实施例：每100重量份的原料中含有鹅不食草10重量份，每100重量份的原料中含有辛夷花6重量份，每100重量份的原料中含有薄荷脑15重量份，每100重量份的原料中含有海水40重量份，每100重量份的原料中含有植物纤维素5重量份，每100重量份的原料中含有等渗调节剂2重量份，每100重量份的原料中含有黄芩1重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷8重量份，每100重量份的原料中含有藿香7重量份。
做为本发明的一个实施例：每100重量份的原料中含有鹅不食草8重量份，每100重量份的原料中含有辛夷花7重量份，每100重量份的原料中含有薄荷脑12重量份，每100重量份的原料中含有海水46重量份，每100重量份的原料中含有植物纤维素7重量份，每100重量份的原料中含有等渗调节剂1重量份，每100重量份的原料中含有黄芩2重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷6重量份，每100重量份的原料中含有藿香5重量份。
做为本发明的一个实施例：鹅不食草可治鼻塞不通，鼻渊流涕，薄荷脑在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用，辛夷花可治疗急性慢性鼻炎、过敏性鼻炎、肥厚性鼻炎、鼻窦炎、副鼻窦炎等，配合其他药用辅料，有疗效突出、治愈率高、简便廉验、易于临床推广的优点。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点,对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。
Claims (7)
1.一种鼻腔喷雾剂，其特征在于：由以下重量份的原料构成：鹅不食草8-10重量份，辛夷花6-7重量份，薄荷脑12-15重量份，海水34-51重量份，植物纤维素5-7重量份，等渗调节剂1-2重量份，黄芩1-2重量份，苦参6-8重量份，薄荷5-8重量份，藿香5-7重量份。
2.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：所述植物纤维素由麦麸与无机酸捣成浆状，制成α-纤维素，再经处理使纤维素作部分解聚，然后再除去非结晶部分并提纯而得。
3.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：取叶片楔状倒披针形，长7-20mm，宽3-5mm的鹅不食草，研磨粉碎至200目，制成原料中的鹅不食草。
4.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：取辛夷花放入容器中，加入两倍于辛夷花重量的水，形成溶液，浸泡30-50min，利用闪急蒸馏的方法将上述溶液提纯，制成原料中的辛夷花。
5.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：在间甲酚铝存在情况下，对间甲酚进行烷基化反应生成百里酚，经催化加氢得所有四对薄荷脑立体异构体，将其进行蒸馏，取消旋薄荷醇馏分，制造酯后反复重结晶，进行异构体的分离和光学拆分，分离出来的左旋薄荷醇酯，经皂化后得原料中的薄荷脑。
6.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：每100重量份的原料中含有鹅不食草10重量份，每100重量份的原料中含有辛夷花6重量份，每100重量份的原料中含有薄荷脑15重量份，每100重量份的原料中含有海水40重量份，每100重量份的原料中含有植物纤维素5重量份，每100重量份的原料中含有等渗调节剂2重量份，每100重量份的原料中含有黄芩1重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷8重量份，每100重量份的原料中含有藿香7重量份。
7.根据权利要求1所述的一种鼻腔喷雾剂，其特征在于：每100重量份的原料中含有鹅不食草8重量份，每100重量份的原料中含有辛夷花7重量份，每100重量份的原料中含有薄荷脑12重量份，每100重量份的原料中含有海水46重量份，每100重量份的原料中含有植物纤维素7重量份，每100重量份的原料中含有等渗调节剂1重量份，每100重量份的原料中含有黄芩2重量份，每100重量份的原料中含有苦参6重量份，每100重量份的原料中含有薄荷6重量份，每100重量份的原料中含有藿香5重量份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610834185.5A CN106309558A (zh) | 2016-09-20 | 2016-09-20 | 一种鼻腔喷雾剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610834185.5A CN106309558A (zh) | 2016-09-20 | 2016-09-20 | 一种鼻腔喷雾剂 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309558A true CN106309558A (zh) | 2017-01-11 |
Family
ID=57787491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610834185.5A Pending CN106309558A (zh) | 2016-09-20 | 2016-09-20 | 一种鼻腔喷雾剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309558A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214549A (zh) * | 2020-03-10 | 2020-06-02 | 江苏医药职业学院 | 一种鼻腔护理喷雾剂及其制备方法 |
| CN112843091A (zh) * | 2021-01-11 | 2021-05-28 | 云南中翼鼎东生物医疗科技有限公司 | 一种含有褐煤提取液的鼻炎抑菌喷剂及制备方法和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042994A (zh) * | 2014-07-01 | 2014-09-17 | 宣伟军 | 一种复方中药鼻腔喷雾剂的制备方法 |
| CN104257752A (zh) * | 2014-10-09 | 2015-01-07 | 成都市康飞药业有限公司 | 一种治疗鼻炎的药物组合物及其用途 |
-
2016
- 2016-09-20 CN CN201610834185.5A patent/CN106309558A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042994A (zh) * | 2014-07-01 | 2014-09-17 | 宣伟军 | 一种复方中药鼻腔喷雾剂的制备方法 |
| CN104257752A (zh) * | 2014-10-09 | 2015-01-07 | 成都市康飞药业有限公司 | 一种治疗鼻炎的药物组合物及其用途 |
Non-Patent Citations (2)
| Title |
|---|
| 崔英德: "《实用化工工艺 中册》", 31 August 2002, 化学工业出版社 * |
| 潘卫三: "《新药制剂技术》", 31 October 2004, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214549A (zh) * | 2020-03-10 | 2020-06-02 | 江苏医药职业学院 | 一种鼻腔护理喷雾剂及其制备方法 |
| CN112843091A (zh) * | 2021-01-11 | 2021-05-28 | 云南中翼鼎东生物医疗科技有限公司 | 一种含有褐煤提取液的鼻炎抑菌喷剂及制备方法和用途 |
| CN112843091B (zh) * | 2021-01-11 | 2022-10-18 | 云南中翼鼎东生物医疗科技有限公司 | 一种含有褐煤提取液的鼻炎抑菌喷剂及制备方法和用途 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5336656B2 (ja) | 気管支炎を治療するための麻黄含有医薬組成物およびその調製方法 | |
| ES2949139T3 (es) | Composición que elimina la congestión nasal y que tiene actividad antivírica | |
| CN102258574B (zh) | 一种治疗过敏性鼻炎的中药制剂 | |
| CN106389618A (zh) | 一种治疗鼻炎、鼻窦炎的中药制剂和使用方法 | |
| CN106309558A (zh) | 一种鼻腔喷雾剂 | |
| CN101041049A (zh) | 一种内服治疗慢性支气管炎的中药组合物 | |
| CN104840521A (zh) | 一种治疗鼻炎的药物组合物 | |
| CN100562328C (zh) | 一种治疗感冒的中药组合物 | |
| CN103230513B (zh) | 一种治疗急慢性鼻炎的中药组合剂及其制备方法 | |
| CN104606137A (zh) | 一种抗菌修复型鼻腔喷雾剂 | |
| CN104706789A (zh) | 一种治疗慢性化脓性中耳炎的中药 | |
| CN101129755A (zh) | 一种内服治疗哮喘的中药组合物 | |
| CN106421693A (zh) | 一种用于呼吸道外置吸入式治疗药物 | |
| Miller | Chronic inflammatory bronchopulmonary disorders: A physiologically oriented approach to treatment | |
| CN100463684C (zh) | 一种治疗鼻炎的药物组合物及其制备方法 | |
| CN111494520A (zh) | 一种治疗鼻炎的药物及其制备方法和应用 | |
| CN105169001A (zh) | 一种用于治疗小儿咳嗽变异性哮喘的中药组合物 | |
| CN101085194B (zh) | 一种内服治疗哮喘的中药组合物 | |
| CN108403863A (zh) | 一种治疗鼻炎的鼻速康制剂 | |
| CN103251701B (zh) | 一种治疗鼻炎的中药组合物 | |
| CN114099579B (zh) | 一种治疗腺样体肥大及其并发症的中药组合物及其制备方法和应用 | |
| CN109464562B (zh) | 一种治疗鼻炎的中药组合物 | |
| RU2401119C2 (ru) | Способ и средство для реабилитации детей с хроническими риносинуситами | |
| CN105125880A (zh) | 一种治疗慢性扁桃体炎的中药 | |
| CN101041002A (zh) | 一种内服治疗鼻窦炎的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170111 |