CN106309204B - A kind of composition for skin repair - Google Patents

A kind of composition for skin repair Download PDF

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Publication number
CN106309204B
CN106309204B CN201610817313.5A CN201610817313A CN106309204B CN 106309204 B CN106309204 B CN 106309204B CN 201610817313 A CN201610817313 A CN 201610817313A CN 106309204 B CN106309204 B CN 106309204B
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China
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composition
skin
weight
basis
glycerine
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CN201610817313.5A
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Chinese (zh)
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CN106309204A (en
Inventor
郑绍普
李程
项春生
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Ipm Biopharm Co Ltd
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Ipm Biopharm Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

The present disclosure discloses a kind of composition for skin repair; the composition contains active ingredient; the active ingredient includes hyaluronic acid, oat beta glucan, yeast lysis extract, biological carbohydrate gum 1, acetyl group hexapeptide 8 and palmityl tripeptides 5, the active ingredient of said composition and further includes glycerine.Said composition effectively can repair skin injury by the combination of a variety of active ingredients, promote the healing of skin wound, while can repair chapped skin, acne print, color spot, wrinkle, scar.

Description

A kind of composition for skin repair
Technical field
A kind of this disclosure relates to skin care implement field, and in particular, to composition for skin repair.
Background technology
People's living standard is improving, emphasis of the people to skin nursing, higher and higher to product requirement while undesirable Injury of many factors such as habits and customs, adverse circumstances, ultraviolet, various stress, incorrect skin nursing to skin, More and more people's chapped skin, oedema, an acne, skin follow the string, the synthtic price index of the skin disorder such as coarse aging Puzzlement.The skin care item of in the market are although various, but often due to addition chemicals, strong acid and strong base, chemical preservative the problems such as, It cannot not only achieve the purpose that to protect skin, skin is produced dependence or is had intense stimulus to skin.It is therefore desirable to Develop it is a kind of can comprehensive repair be damaged skin and promote the product of skin revitalization, meet the needs of market.
The content of the invention
The purpose of the disclosure is to provide a kind of composition, and said composition can be effectively right by the combination of a variety of active ingredients Skin injury is repaired, and promotes the healing of skin wound, while can repair chapped skin, acne print, color spot, wrinkle, scar.
To achieve these goals, the disclosure provides a kind of composition for skin repair, contains in the composition Active ingredient, it is characterised in that the active ingredient includes hyaluronic acid, avenabeta glucosan, yeast lysis extract, biology Carbohydrate gum -1, Argireline and palmityl tripeptides -5.
Through the above technical solutions, the present invention can quickly repair skin injury, promote wound growth healing, keep at the same time Skin water profit is salubrious, makes skin exquisiteness gloss, keeps cell moisture, and protection cell is accelerated to recover skin from the infringement of pathogen Skin tissue, improves Wound healing power of regeneration, reduces the effect such as scar, strengthen immunity.Therefore, composition of the invention can be with Play and effectively repair skin injury, promote the healing of skin wound, while repair chapped skin, acne print, color spot, wrinkle, scar.
Other feature and advantage of the disclosure will be described in detail in subsequent specific embodiment part.
Embodiment
The embodiment of the disclosure is described in detail below.It is it should be appreciated that described herein specific Embodiment is only used for describing and explaining the disclosure, is not limited to the disclosure.
Present disclose provides a kind of composition for skin repair, contain active ingredient in the composition, its feature It is, the active ingredient can include hyaluronic acid, avenabeta glucosan, yeast lysis extract, biological carbohydrate gum -1, acetyl Base hexapeptide -8 and palmityl tripeptides -5.
Through the above technical solutions, the disclosure can quickly repair skin injury, promote wound growth healing, keep at the same time Skin water profit is salubrious, makes skin exquisiteness gloss.Infringement of the cell from pathogen is protected, accelerates to recover skin histology, improves wound Mouth healing power of regeneration, reduces the effect such as scar, strengthen immunity.Therefore, composition of the invention can play effective reparation Skin injury, promotes the healing of skin wound, while repairs chapped skin, acne print, color spot, wrinkle, scar.
Further, in order to strengthen the moisturizing moisturizing effect of the disclosure, the active ingredient can also contain glycerine.
Further, in order to make the physicochemical property of the composition of the disclosure keep stablizing, can also contain in the composition Have auxiliary element and the solvent of surplus, on the basis of the gross weight of the composition and by weight percentage, it is described auxiliary into The content divided is 0.1-2%, and the content of the active ingredient is 3.3-16.5%.
Further, in order to extend the storage time of the composition of the disclosure, the auxiliary element is preferably preservative, The preservative is selected from least one of Phenoxyethanol, methyl hydroxybenzoate, sorbic acid and imidazolidinyl urea, and the solvent is selected from At least one of deionized water, distilled water, ethanol and isopropanol.
Further, in order to obtain more preferable using effect, on the basis of the gross weight of the composition and with weight hundred Divide than meter, the composition can the hyaluronic acid containing 0.01-0.5%, the avenabeta glucosan of 0.8-2%, 0.5-3% Yeast lysis extract, the glycerine of 1-5%, the biological carbohydrate gum -1 of 0.5-3%, 0.0001-0.0008% acetyl group hexapeptide - 8th, the Phenoxyethanol of the palmityl tripeptides -5 of 0.5-3% and 0.1-0.5%.It is furthermore preferred that the composition contains weight ratio is 0.3% hyaluronic acid, 1% avenabeta glucosan, 1.5% yeast lysis extract, 4% glycerine, 2% biology sugar Glue -1,0.0003% Argireline, 1.5% palmityl tripeptides -5,0.3% Phenoxyethanol.
Further, the composition also deionized water containing surplus.
On the other hand, the disclosure additionally provides use of the composition in preparing water profit and repairing the cosmetics of skin On the way.
The cosmetics can be facial mask, lotion, face cream, moisturiser and beautifying liquid.
The disclosure additionally provides purposes of the composition in the medicine for repairing skin is prepared.
The disclosure is further elaborated by the following examples, and is not so limited the disclosure.
Embodiment 1
On the basis of the gross weight of composition and by weight percentage, the composition contain 0.5% hyaluronic acid, 2% avenabeta glucosan, 3% yeast lysis extract, 5% glycerine, 3% biological carbohydrate gum -1,0.0008% second The palmityl tripeptides -5 and 0.5% Phenoxyethanol of acyl group hexapeptide -8,3%, surplus is deionized water.
Embodiment 2
On the basis of the gross weight of composition and by weight percentage, the composition contains 0.01% hyalomitome Acid, 0.8% avenabeta glucosan, 0.5% yeast lysis extract, 1% glycerine, 0.5% biological carbohydrate gum -1, 0.0001% Argireline, 0.5% palmityl tripeptides -5 and 0.1% Phenoxyethanol, surplus are deionized water.
Embodiment 3
On the basis of the gross weight of composition and by weight percentage, the composition contain 0.1% hyaluronic acid, 1% avenabeta glucosan, 2% yeast lysis extract, 2% glycerine, 1% biological carbohydrate gum -1,0.0002% second The palmityl tripeptides -5 and 0.1% Phenoxyethanol of acyl group hexapeptide -8,1%, surplus is deionized water.
Embodiment 4
On the basis of the gross weight of composition and by weight percentage, the composition contain 0.3% hyaluronic acid, 1% avenabeta glucosan, 1.5% yeast lysis extract, 4% glycerine, 2% biological carbohydrate gum -1,0.0003% Argireline, 1.5% palmityl tripeptides -5 and 0.3% Phenoxyethanol, surplus are deionized water.
Comparative example 1
On the basis of the gross weight of composition and by weight percentage, the composition contains 0.5% hydrolytic collagen Albumen, 2% avenabeta glucosan, 3% yeast lysis extract, 5% glycerine, 3% biological carbohydrate gum -1,0.0008% Argireline, 3% palmityl tripeptides -5 and 0.5% Phenoxyethanol, surplus is deionized water.
Comparative example 2
On the basis of the gross weight of composition and by weight percentage, the composition contain 0.5% hyaluronic acid, 2% soluble protein polysaccharide, 3% yeast lysis extract, 5% glycerine, 3% biological carbohydrate gum -1,0.0008% Argireline, 3% palmityl tripeptides -5 and 0.5% Phenoxyethanol, surplus are deionized water.
Comparative example 3
On the basis of the gross weight of composition and by weight percentage, the composition contain 0.5% hyaluronic acid, 2% soluble protein polysaccharide, 3% aloe extract, 5% glycerine, 3% biological carbohydrate gum -1,0.0008% acetyl The palmityl tripeptides -5 and 0.5% Phenoxyethanol of base hexapeptide -8,3%, surplus is deionized water.
Testing example 1
In order to verify the using effect of the present invention, the composition of embodiment 1-4, comparative example 1-3, control group is tested Contrast, experiment condition are：The 1cm by SD rat back backbones both sides, both ends are parallel to backbone one diameter of each mark end to end 1.8cm, area 2.54cm2Circular incision line.After iodophor disinfection skin, full thickness skin is wiped out to depth along mark line with scissors Fascia, forms 4 circular surface of a wound.Left side wound uses embodiment, and the embodiment of the present invention or comparative example are fitted into syringe, Left side is applied to, gives composition described in 200 μ l, right side wound is covered with gauze and wrapped up without handling as a control group. In the observation of continuous 10 days, the wound area of both sides was shown in Table 1 relative to first day wound area ratio：
Table 1
After processing 1 day 2 days 4 days 6 days 8 days 10 days
Embodiment 1 1 0.96 0.94 0.79 0.67 0.54
Embodiment 2 1 0.97 0.93 0.76 0.73 0.68
Embodiment 3 1 0.95 0.86 0.82 0.72 0.63
Embodiment 4 1 0.95 0.84 0.74 0.65 0.51
Comparative example 1 1 0.98 0.97 0.93 0.86 0.76
Comparative example 2 1 0.99 0.98 0.91 0.88 0.75
Comparative example 3 1 0.97 0.94 0.94 0.87 0.84
Control group 1 0.98 0.96 0.95 0.93 0.88
Testing example 2
In order to verify the using effect of the present invention, the composition of embodiment 1-4, comparative example 1-3 are subjected to Experimental comparison, it is real The condition of testing is：28 testees need first wash hands forearm, and 3 × 3cm is marked in tester or so forearm side2The square of size Experimental Area, each Test sites are tested using moisture of skin tester (being purchased from Corneometer companies, model CM825) Moisture, 3.5g compositions, right arm symmetrical area accordingly are smeared using left arm as the test zone of embodiment or comparative example Anything is not smeared for control group in domain, then sits quietly under 40% humidity environment, through in half an hour, 1 it is small when, 1.5 it is small when, 2 it is small when, 3 it is small when after reuse the moisture that moisture of skin tester tests each Test sites, draw what is tested every time Average value, records data, then average hydration rate of the subject in different time intervals point, lifting effect is calculated by formula (A) Fruit is shown in Table 2：
Table 2
After processing 0 it is small when 0.5 it is small when 1 it is small when 1.5 it is small when 2 it is small when 3 it is small when
Embodiment 1 2.34 105.31 94.64 95.64 104.67 108.34
Embodiment 2 1.64 96.14 89.48 88.27 99.17 96.43
Embodiment 3 3.48 84.16 79.36 84.91 94.34 88.49
Embodiment 4 1.96 112.64 103.48 106.17 114.67 121.34
Comparative example 1 1.38 67.34 49.64 51.67 56.92 53.17
Comparative example 2 2.13 82.84 75.41 68.14 72.06 74.19
Comparative example 3 0.84 76.15 71.04 64.37 74.97 68.18
Control group 1.48 1.93 1.61 1.51 1.44 1.21
Comparative example 1 is can be seen that from table 1,2 compared with Example 1, and hyaluronic acid is used cooperatively with other compositions and relatively hydrolyzes Collagen is more preferable with the use of effect with other compositions；Comparative example 2 compared with Example 1, avenabeta glucosan with other into Divide with the use of more preferable with the use of effect with other compositions compared with soluble protein polysaccharide；Comparative example 3 compared with Example 1, ferment Female lysis extract is more preferable with the use of effect with other compositions compared with aloe extract；Preferable scope embodiment 4 and embodiment 1st, 2,3 compare, there is more preferable effect.The present composition can quickly repair skin injury, promote wound growth healing, together When keep skin water profit salubrious, make skin exquisiteness gloss.Infringement of the cell from pathogen is protected, accelerates to recover skin histology, Wound healing power of regeneration is improved, reduces the effect such as scar, strengthen immunity.Therefore, composition of the invention can play Effect repairs skin injury, promotes the healing of skin wound, while repair chapped skin, acne print, color spot, wrinkle, scar.
The preferred embodiment of the disclosure described in detail above, still, the disclosure is not limited in the above embodiment Detail, in the range of the technology design of the disclosure, a variety of simple variants can be carried out to the technical solution of the disclosure, this A little simple variants belong to the protection domain of the disclosure.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance In the case of shield, it can be combined by any suitable means.In order to avoid unnecessary repetition, the disclosure to it is various can The combination of energy no longer separately illustrates.
In addition, it can also be combined between a variety of embodiments of the disclosure, as long as it is without prejudice to originally Disclosed thought, it should equally be considered as disclosure disclosure of that.

Claims (8)

1. a kind of composition for skin repair, contain active ingredient in the composition, it is characterised in that with the combination On the basis of the gross weight of thing and by weight percentage, the active ingredient includes hyaluronic acid, the 0.8-2% of 0.01-0.5% Avenabeta glucosan, the yeast lysis extract of 0.5-3%, the biological carbohydrate gum -1 of 0.5-3%, 0.0001-0.0008% The glycerine of Argireline, the palmityl tripeptides -5 of 0.5-3% and 1-5%.
2. composition according to claim 1, wherein, the solvent in the composition also containing auxiliary element and surplus, On the basis of the gross weight of the composition and by weight percentage, the content of the auxiliary element is 0.1-2%, the work The content of property component is 3.3101-16.5%.
3. composition according to claim 2, wherein, the auxiliary element includes preservative, and the preservative is selected from benzene At least one of oxyethanol, methyl hydroxybenzoate, sorbic acid and imidazolidinyl urea, the solvent be selected from deionized water, distilled water, At least one of ethanol and isopropanol.
4. composition according to claim 3, wherein, on the basis of the gross weight of the composition and with percentage by weight Meter, it is molten that the composition contains the hyaluronic acid of 0.01-0.5%, the avenabeta glucosan of 0.8-2%, the yeast of 0.5-3% Born of the same parents' extract, the glycerine of 1-5%, the biological carbohydrate gum -1 of 0.5-3%, the Argireline of 0.0001-0.0008%, 0.5- 3% palmityl tripeptides -5 and the Phenoxyethanol of 0.1-0.5%.
5. composition according to claim 4, wherein, on the basis of the gross weight of the composition and with percentage by weight Meter, the composition contain the hyaluronic acid, 1% avenabeta glucosan, 1.5% yeast lysis that weight ratio is 0.3% and carry Take thing, 4% glycerine, 2% biological carbohydrate gum -1,0.0003% Argireline, 1.5% palmityl tripeptides -5 and 0.3% Phenoxyethanol.
6. purposes of the composition in preparing water profit and repairing the cosmetics of skin in claim 1-5 described in any one.
7. purposes according to claim 6, wherein, the cosmetics are facial mask, lotion or face cream.
8. purposes of the composition in the medicine for repairing skin is prepared in claim 1-5 described in any one.
CN201610817313.5A 2016-09-12 2016-09-12 A kind of composition for skin repair Active CN106309204B (en)

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CN110227177B (en) * 2019-05-23 2021-08-03 中山市粤美医疗生物科技有限公司 Dressing containing carrageenan and preparation method thereof
CN110693806A (en) * 2019-10-24 2020-01-17 广州澳梓美生物科技有限公司 Skin care composition, skin care essence and preparation method thereof
CN111920719B (en) * 2020-08-28 2021-09-07 广州市万千粉丝化妆品有限公司 Composition for improving acne marks and scars and preparation method thereof
CN113662899A (en) * 2021-08-09 2021-11-19 杭州淳知然生物科技有限公司 Composition for skin repair and preparation method thereof
CN115778853A (en) * 2022-12-07 2023-03-14 哈尔滨欧替药业有限公司 Anti-aging essence containing oviductus ranae enzymolysis peptide and preparation method thereof

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US20110280850A1 (en) * 2010-05-12 2011-11-17 Starr Elizabeth I Compositions Containing DNA Repair Enzyme And Anogeissus Extract
CN104814896B (en) * 2015-05-08 2018-03-23 广州依侬化妆品有限公司 A kind of skin care item
CN105726456B (en) * 2016-03-01 2018-11-13 广州市有喜化妆品有限公司 A kind of herbaceous plant nutritive water and preparation method thereof of emulsification microcapsules
CN105616522A (en) * 2016-03-02 2016-06-01 广州千百度化妆品有限公司 Traditional Chinese medicine acne cream

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