CN106309204A - Composition for skin regeneration - Google Patents
Composition for skin regeneration Download PDFInfo
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- CN106309204A CN106309204A CN201610817313.5A CN201610817313A CN106309204A CN 106309204 A CN106309204 A CN 106309204A CN 201610817313 A CN201610817313 A CN 201610817313A CN 106309204 A CN106309204 A CN 106309204A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a composition for skin regeneration. The composition comprises active components, and the active components include hyaluronic acid, oat beta-glucan, yeast lysis extract, biosaccharide gum-1, acetyl hexapeptide-8 and palmityl tripeptide-5; the active components of the composition also include glycerinum. Through combining multiple active components, the composition can effectively restore the skin damage and promote the skin wound healing; meanwhile, the composition also can restore skin crack, smallpox, stain, wrinkle, and scar.
Description
Technical field
It relates to skin care implement field, in particular it relates to a kind of compositions for skin repair.
Background technology
People's living standard is improving, and people's emphasis to skin nursing is more and more higher to product requirement, the worst
The many factors injuries to skin such as living habit, adverse circumstances, ultraviolet, various stress, incorrect skin nursing,
Increasing application on human skin is dry and cracked, edema, a pox, skin follow the string, the coarse aging synthtic price index waiting skin disorderly
Puzzlement.Although the skin care item on market are various, but often due to add the problems such as chemicals, strong acid and strong base, chemical preservative,
Not only can not reach to protect the purpose of skin, skin also can be made to produce dependency or skin is had intense stimulus.It is therefore desirable to
Develop a kind of can the impaired skin of comprehensive repair promote the product of skin revitalization, meet the demand in market.
Summary of the invention
The purpose of the disclosure is to provide a kind of compositions, and said composition can be the most right by the combination of various active composition
Skin injury is repaired, and promotes the healing of skin wound, can repair chapped skin, pox print, mottle, wrinkle, cicatrix simultaneously.
To achieve these goals, the disclosure provides a kind of compositions for skin repair, contains in described compositions
Active component, it is characterised in that described active component includes hyaluronic acid, avenabeta glucosan, yeast lysis extract, biology
Carbohydrate gum-1, Argireline and palmityl tripeptides-5.
By technique scheme, the present invention can quickly repair skin injury, promotes wound growth healing, keeps simultaneously
Skin beauty water profit is salubrious, makes skin exquisiteness gloss, keeps cell moisture, protection cell not to be encroached on by pathogen, accelerates to recover skin
The effects such as skin tissue, improves wound healing regeneration capacity, reduces cicatrix, enhancing immunity.Therefore, the compositions of the present invention is permissible
Play and effectively repair skin injury, promote the healing of skin wound, repair chapped skin, pox print, mottle, wrinkle, cicatrix simultaneously.
Other feature and advantage of the disclosure will be described in detail in detailed description of the invention part subsequently.
Detailed description of the invention
Detailed description of the invention the most of this disclosure is described in detail.It should be appreciated that described herein specifically
Embodiment is merely to illustrate and explains the disclosure, is not limited to the disclosure.
Present disclose provides a kind of compositions for skin repair, containing active component in described compositions, its feature
Being, described active component can include hyaluronic acid, avenabeta glucosan, yeast lysis extract, biological carbohydrate gum-1, acetyl
Base hexapeptide-8 and palmityl tripeptides-5.
By technique scheme, the disclosure can quickly repair skin injury, promotes wound growth healing, keeps simultaneously
Skin beauty water profit is salubrious, makes skin exquisiteness gloss.Protection cell is not encroached on by pathogen, accelerates to recover skin histology, improves wound
The effects such as mouth healing regeneration capacity, reduces cicatrix, enhancing immunity.Therefore, the compositions of the present invention can play effectively reparation
Skin injury, promotes the healing of skin wound, repairs chapped skin, pox print, mottle, wrinkle, cicatrix simultaneously.
Further, in order to strengthen the moisturizing moisturizing effect of the disclosure, described active component can also contain glycerol.
Further, in order to make the physicochemical property of the compositions of the disclosure keep stable, described compositions can also contain
There is the solvent of auxiliary element and surplus, on the basis of the gross weight of described compositions and by weight percentage, described assist into
The content divided is 0.1-2%, and the content of described active component is 3.3-16.5%.
Further, in order to make the storage time lengthening of the compositions of the disclosure, described auxiliary element is preferably preservative,
At least one in phenoxyethanol, methyl hydroxybenzoate, sorbic acid and imidazolidinyl urea of described preservative, described solvent is selected from
At least one in deionized water, distilled water, ethanol and isopropanol.
Further, in order to obtain more preferable using effect, on the basis of the gross weight of described compositions and with weight hundred
Proportion by subtraction meter, described compositions can contain the hyaluronic acid of 0.01-0.5%, the avenabeta glucosan of 0.8-2%, 0.5-3%
Yeast lysis extract, the glycerol of 1-5%, the biological carbohydrate gum-1 of 0.5-3%, 0.0001-0.0008% acetyl group hexapeptide-
8, the phenoxyethanol of the palmityl tripeptides-5 and 0.1-0.5% of 0.5-3%.It is furthermore preferred that described compositions contains weight ratio it is
The hyaluronic acid of 0.3%, the avenabeta glucosan of 1%, the yeast lysis extract of 1.5%, the glycerol of 4%, the biological sugar of 2%
Glue-1, the Argireline of 0.0003%, the phenoxyethanol of palmityl tripeptides-5,0.3% of 1.5%.
Further, described compositions is possibly together with the deionized water of surplus.
On the other hand, the disclosure additionally provides described compositions use in the cosmetics preparing water profit reparation skin
On the way.
Described cosmetics can be facial film, emulsion, facial cream, moisturiser and beautifying liquid.
The disclosure additionally provides described compositions purposes in the medicine of skin is repaired in preparation.
Be further elaborated the disclosure by the following examples, and is not so limited the disclosure.
Embodiment 1
On the basis of the gross weight of compositions and by weight percentage, described compositions contain 0.5% hyaluronic acid,
The avenabeta glucosan of 2%, the yeast lysis extract of 3%, the glycerol of 5%, the biological carbohydrate gum-1 of 3%, the second of 0.0008%
The palmityl tripeptides-5 of acyl group hexapeptide-8,3% and the phenoxyethanol of 0.5%, surplus is deionized water.
Embodiment 2
On the basis of the gross weight of compositions and by weight percentage, described compositions contains the hyalomitome of 0.01%
Acid, the avenabeta glucosan of 0.8%, the yeast lysis extract of 0.5%, the glycerol of 1%, the biological carbohydrate gum-1 of 0.5%,
The Argireline of 0.0001%, the palmityl tripeptides-5 of 0.5% and the phenoxyethanol of 0.1%, surplus is deionized water.
Embodiment 3
On the basis of the gross weight of compositions and by weight percentage, described compositions contain 0.1% hyaluronic acid,
The avenabeta glucosan of 1%, the yeast lysis extract of 2%, the glycerol of 2%, the biological carbohydrate gum-1 of 1%, the second of 0.0002%
The palmityl tripeptides-5 of acyl group hexapeptide-8,1% and the phenoxyethanol of 0.1%, surplus is deionized water.
Embodiment 4
On the basis of the gross weight of compositions and by weight percentage, described compositions contain 0.3% hyaluronic acid,
The avenabeta glucosan of 1%, the yeast lysis extract of 1.5%, the glycerol of 4%, the biological carbohydrate gum-1 of 2%, 0.0003%
Argireline, the palmityl tripeptides-5 of 1.5% and the phenoxyethanol of 0.3%, surplus is deionized water.
Comparative example 1
On the basis of the gross weight of compositions and by weight percentage, described compositions contains the hydrolytic collagen of 0.5%
Albumen, the avenabeta glucosan of 2%, the yeast lysis extract of 3%, the glycerol of 5%, the biological carbohydrate gum-1 of 3%, 0.0008%
Argireline, the palmityl tripeptides-5 of 3% and the phenoxyethanol of 0.5%, surplus is deionized water.
Comparative example 2
On the basis of the gross weight of compositions and by weight percentage, described compositions contain 0.5% hyaluronic acid,
The soluble protein polysaccharide of 2%, the yeast lysis extract of 3%, the glycerol of 5%, the biological carbohydrate gum-1 of 3%, 0.0008%
Argireline, the palmityl tripeptides-5 of 3% and the phenoxyethanol of 0.5%, surplus is deionized water.
Comparative example 3
On the basis of the gross weight of compositions and by weight percentage, described compositions contain 0.5% hyaluronic acid,
The soluble protein polysaccharide of 2%, the Aloe extract of 3%, the glycerol of 5%, the biological carbohydrate gum-1 of 3%, the acetyl of 0.0008%
The palmityl tripeptides-5 of base hexapeptide-8,3% and the phenoxyethanol of 0.5%, surplus is deionized water.
Testing example 1
In order to verify the using effect of the present invention, embodiment 1-4, comparative example 1-3, the compositions of matched group are tested
Contrast, experiment condition is: the other 1cm in SD rat back spinal column both sides, two ends are parallel to one diameter of each labelling of spinal column end to end
1.8cm, area 2.54cm2Circular incision line.After iodophor disinfection skin, wipe out full thickness skin to deeply with shears along mark line
Fascia, forms 4 circular wound surface.Left side wound uses embodiment, loads in syringe by embodiments of the invention or comparative example,
Being applied in left side, give compositions described in 200 μ l, right side wound does not carry out processing as a control group, all covers wrapping with gauze.
In the observation of continuous 10 days, the wound area of both sides is shown in Table 1 relative to first day wound area ratio:
Table 1
| After process | 1 day | 2 days | 4 days | 6 days | 8 days | 10 days |
| Embodiment 1 | 1 | 0.96 | 0.94 | 0.79 | 0.67 | 0.54 |
| Embodiment 2 | 1 | 0.97 | 0.93 | 0.76 | 0.73 | 0.68 |
| Embodiment 3 | 1 | 0.95 | 0.86 | 0.82 | 0.72 | 0.63 |
| Embodiment 4 | 1 | 0.95 | 0.84 | 0.74 | 0.65 | 0.51 |
| Comparative example 1 | 1 | 0.98 | 0.97 | 0.93 | 0.86 | 0.76 |
| Comparative example 2 | 1 | 0.99 | 0.98 | 0.91 | 0.88 | 0.75 |
| Comparative example 3 | 1 | 0.97 | 0.94 | 0.94 | 0.87 | 0.84 |
| Matched group | 1 | 0.98 | 0.96 | 0.95 | 0.93 | 0.88 |
Testing example 2
In order to verify the using effect of the present invention, the compositions of embodiment 1-4, comparative example 1-3 is carried out Experimental comparison, real
The condition of testing is: 28 testees need first wash hands forearm, mark 3 × 3cm in forearm side, tester left and right2The square of size
Experimental Area, uses moisture of skin tester (purchased from Corneometer company, model is CM825) to test each Test sites
Moisture, smear 3.5g compositions using left arm as the test zone of embodiment or comparative example, right arm symmetrical district accordingly
Territory is that matched group does not smear anything, then sits quietly under 40% humidity environment, through in half an hour, 1 hour, 1.5 hours,
2 hours, reuse moisture of skin tester after 3 hours and test the moisture of each Test sites, draw every time test
Meansigma methods, records data, then calculates the experimenter's average hydration rate in different time spaced points by formula (A), promote effect
Fruit is shown in Table 2:
Table 2
| After process | 0 hour | 0.5 hour | 1 hour | 1.5 hour | 2 hours | 3 hours |
| Embodiment 1 | 2.34 | 105.31 | 94.64 | 95.64 | 104.67 | 108.34 |
| Embodiment 2 | 1.64 | 96.14 | 89.48 | 88.27 | 99.17 | 96.43 |
| Embodiment 3 | 3.48 | 84.16 | 79.36 | 84.91 | 94.34 | 88.49 |
| Embodiment 4 | 1.96 | 112.64 | 103.48 | 106.17 | 114.67 | 121.34 |
| Comparative example 1 | 1.38 | 67.34 | 49.64 | 51.67 | 56.92 | 53.17 |
| Comparative example 2 | 2.13 | 82.84 | 75.41 | 68.14 | 72.06 | 74.19 |
| Comparative example 3 | 0.84 | 76.15 | 71.04 | 64.37 | 74.97 | 68.18 |
| Matched group | 1.48 | 1.93 | 1.61 | 1.51 | 1.44 | 1.21 |
Can be seen that comparative example 1 compared with Example 1 from table 1,2, hyaluronic acid uses with other components matching and relatively hydrolyzes
Collagen protein is more preferable with other components matching using effects；Compared with Example 1, avenabeta glucosan becomes comparative example 2 with other
Divide with the use of more preferable with other components matching using effects compared with soluble protein polysaccharide；Comparative example 3 compared with Example 1, ferment
Female lysis extract is more preferable with other components matching using effects compared with Aloe extract；Preferably scope embodiment 4 and embodiment
1,2,3 compare, there is more preferable effect.The present composition can quickly repair skin injury, promotes wound growth healing, with
Time keep skin beauty water profit salubrious, make skin exquisiteness gloss.Protection cell is not encroached on by pathogen, accelerates to recover skin histology,
Improving wound healing regeneration capacity, reduce cicatrix, enhancing immunity etc. acts on.Therefore, the compositions of the present invention can play
Effect repairs skin injury, promotes the healing of skin wound, repairs chapped skin, pox print, mottle, wrinkle, cicatrix simultaneously.
The preferred implementation of the disclosure described in detail above, but, the disclosure is not limited in above-mentioned embodiment
Detail, in the technology concept of the disclosure, multiple simple variant can be carried out with technical scheme of this disclosure, this
A little simple variant belong to the protection domain of the disclosure.
It is further to note that each the concrete technical characteristic described in above-mentioned detailed description of the invention, at not lance
In the case of shield, can be combined by any suitable means.In order to avoid unnecessary repetition, the disclosure to various can
The compound mode of energy illustrates the most separately.
Additionally, combination in any can also be carried out between the various different embodiment of the disclosure, as long as it is without prejudice to this
Disclosed thought, it should be considered as disclosure disclosure of that equally.
Claims (10)
1. for a compositions for skin repair, containing active component in described compositions, it is characterised in that described activity becomes
Divide and include hyaluronic acid, avenabeta glucosan, yeast lysis extract, biological carbohydrate gum-1, Argireline and palmityl three
Peptide-5.
Compositions the most according to claim 1, wherein, described active component is possibly together with glycerol.
Compositions the most according to claim 1 and 2, wherein, molten possibly together with auxiliary element and surplus in described compositions
Agent, on the basis of the gross weight of described compositions and by weight percentage, the content of described auxiliary element is 0.1-2%, institute
The content stating active component is 3.3-16.5%.
Compositions the most according to claim 3, wherein, described auxiliary element includes preservative, and described preservative is selected from benzene
At least one in oxyethanol, methyl hydroxybenzoate, sorbic acid and imidazolidinyl urea, described solvent selected from deionized water, distilled water,
At least one in ethanol and isopropanol.
Compositions the most according to claim 4, wherein, on the basis of the gross weight of described compositions and with percentage by weight
Meter, described compositions contain the hyaluronic acid of 0.01-0.5%, the avenabeta glucosan of 0.8-2%, 0.5-3% yeast molten
Born of the same parents' extract, the glycerol of 1-5%, the biological carbohydrate gum-1 of 0.5-3%, the Argireline of 0.0001-0.0008%, 0.5-
The phenoxyethanol of the palmityl tripeptides-5 and 0.1-0.5% of 3%.
Compositions the most according to claim 5, wherein, on the basis of the gross weight of described compositions and with percentage by weight
Meter, described compositions contains hyaluronic acid that weight ratio is 0.3%, the avenabeta glucosan of 1%, the yeast lysis of 1.5% carry
Take thing, the glycerol of 4%, the biological carbohydrate gum-1 of 2%, the Argireline of 0.0003%, the palmityl tripeptides-5 of 1.5% and
The phenoxyethanol of 0.3%.
7. according to the compositions described in claim 5 or 6, wherein, described compositions is possibly together with the deionized water of surplus.
8. compositions described in any one purposes in the cosmetics preparing water profit and repairing skin in claim 1-7.
Purposes the most according to claim 8, wherein, described cosmetics include facial film, emulsion, facial cream, moisturiser and beauty treatment
Liquid.
10. compositions described in any one purposes in the medicine of skin is repaired in preparation in claim 1-7.
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Cited By (5)
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| CN110693806A (en) * | 2019-10-24 | 2020-01-17 | 广州澳梓美生物科技有限公司 | Skin care composition, skin care essence and preparation method thereof |
| CN111920719A (en) * | 2020-08-28 | 2020-11-13 | 陈绍胜 | Composition for improving acne marks and scars and preparation method thereof |
| CN113662899A (en) * | 2021-08-09 | 2021-11-19 | 杭州淳知然生物科技有限公司 | Composition for skin repair and preparation method thereof |
| CN115778853A (en) * | 2022-12-07 | 2023-03-14 | 哈尔滨欧替药业有限公司 | Anti-aging essence containing oviductus ranae enzymolysis peptide and preparation method thereof |
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Cited By (7)
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| CN110227177A (en) * | 2019-05-23 | 2019-09-13 | 中山市粤美医疗生物科技有限公司 | A kind of dressing and preparation method thereof containing carrageenan |
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| CN111920719A (en) * | 2020-08-28 | 2020-11-13 | 陈绍胜 | Composition for improving acne marks and scars and preparation method thereof |
| CN111920719B (en) * | 2020-08-28 | 2021-09-07 | 广州市万千粉丝化妆品有限公司 | Composition for improving acne marks and scars and preparation method thereof |
| CN113662899A (en) * | 2021-08-09 | 2021-11-19 | 杭州淳知然生物科技有限公司 | Composition for skin repair and preparation method thereof |
| CN115778853A (en) * | 2022-12-07 | 2023-03-14 | 哈尔滨欧替药业有限公司 | Anti-aging essence containing oviductus ranae enzymolysis peptide and preparation method thereof |
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| CN106309204B (en) | 2018-05-11 |
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