CN106266864B - A kind of Chinese medicinal capsule and preparation method for treating paracmasis COPD - Google Patents

Abstract

The present invention relates to a kind of Chinese medicinal capsule and preparation method for treating paracmasis COPD, belong to field of traditional Chinese medicine pharmacy.The Chinese medicinal capsule is made up of the raw material of following parts by weight：55 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 37 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 37 parts of Poria cocos, 55 parts of Herba Epimedii Preparata, 74 parts of the Radix Astragali, 60 parts of gekko, 37 parts of bush, 37 parts of stir-baked SEMEN PERSICAE, 55 parts of earthworm, 37 parts of semen armeniacae amarae of stir-fry, sweet 55 parts of the tuber of stemona, 37 parts of cordate houttuynia, 37 parts of bulbus fritillariae cirrhosae, 37 parts of RADIX POLYGALAE PREPARATA, 37 parts of honey-made mulberry bark, 37 parts of the tuber of dwarf lilyturf, 37 parts of cicada slough, 37 parts of radix glycyrrhizae, 37 parts of Chinese yam and sweet 37 parts of tussilago.The present invention simply and readily controls treatment for treating the Chinese medicine preparation science of paracmasis COPD, reasonable, preparation method, in terms of paracmasis COPD is treated, has the advantages that cure rate is high, uneasy to recur, has no toxic side effect.

Description

A kind of Chinese medicinal capsule and preparation method for treating paracmasis COPD

Technical field

The present invention relates to a kind of Chinese medicinal capsule and preparation method for treating paracmasis COPD, belong to Chinese medicine Pharmaceutical field.

Background technology

COPD (chronic obstructive pulmonary diseases, COPD) be one group with The chronic respiratory disease that not fully reversible property airflow obstruction and progressive development are characterized.This disease is chronic progression process pole Easily repeatedly, delay refractory, custom has saying for " not controlling inside and breathe heavily ".The total category asthenia in origin and asthenia in superficiality of this disease, the evil then inclined domination of pathogen of sense, usually then this void. The domination of pathogen show as the stagnation of the circulation of vital energy, phlegm wet, blood stasis, oedema and it is mixed for suffer from.The dificiency of the lung due to protracted disease then influences spleen, kidney, the heart.It is just the deficiency of vital energy or gas The deficiency of yang or yin-yang deficiency after Yin bivacuity.Its cause of disease is complicated, is common disease in world wide, frequently-occurring disease, specific drug is there is no at present, many Number is treated with anti-inflammatory, pectoral, but effect is not good, easily recurrence.

The cause of disease of COPD is not yet illustrated completely at present, but many factors incidence of disease sick with this increases and had Certain relation, these hazards, which can be divided into external cause i.e. environmental factor, includes smoking respiratory tract infection, Occupational Dust and chemicals Matter；Internal cause is individual susceptible factor, including respiratory tract local defense and immunologic function attenuating, vegetative dystonia, air flue High reaction, lung development undergrowth etc..The prolonged and repeated effect of internal and external factor causes bronchial spasm oedema, and mucus secretion increases Many, alveolar excessively expands, lung arteriolar spasm, a series of pathological changes such as pulmonary circulation is obstructed and progressive is aggravated.Motherland's medical science Think that lung governing qi department breathes, lung being a delicate viscus is easily attacked by exopathogen, damage lung qi causes a surname drop mistake department and sends out cough and asthma.Tuberculosis and spleen Mother-qi, the then turbid interior life of dysfunction of the spleen in transport phlegm are stolen, the failure of the kidney in receiving air, which is moved, then breathes heavily very.

The paracmasis of COPD is mainly lung, spleen, kidney qi deficiency, based on visceral dysfunction, for the disease Mechanism, the present inventor research and development " beautiful wind capsule for tonifying kidney " be directed to the sick mechanism, the present inventor research and development " beautiful wind kidney tonifying glue Capsule " can play a part of controlling and delaying recurrence well in terms of paracmasis COPD is treated.But patient exists This medicinal dose is generally reacted during use big, medicining cycle is long, brought to patient very big constant.

The concocting method States Pharmacopoeia specifications of steamed FRUCTUS SCHISANDRAE with vinegar are：The net fruit of Chinese magnoliavine is taken, method (appendix II D) is steamed according to vinegar and steams to black.

The concocting method States Pharmacopoeia specifications of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran are：Honey wheat bran is sprinkled into hot pot, whitewood is added when smoldering, is fried To yellowish-brown, effusion fragrance, take out, weed out honey wheat bran.

The concocting method States Pharmacopoeia specifications of stir-baked SEMEN PERSICAE are：Melt peach kernel is taken, is fried according to the method for frying (appendix II D) to yellow.

Frying amygdalate concocting method States Pharmacopoeia specifications is：Dan semen armeniacae amaraes are taken, are fried according to the method for frying (appendix II D) to yellow.

The concocting method States Pharmacopoeia specifications of Herba Epimedii Preparata are：Take suet oil heating fusing, add barrenwort silk, fried with slow fire to It is uniform glossy, take out, cool.Per 100kg barrenwort, with suet oil (oil refining) 20kg.

The concocting method States Pharmacopoeia specifications of the sweet tuber of stemona are：The tuber of stemona is taken, it is extremely tack-free to process method (appendix II D) according to honey.

The concocting method States Pharmacopoeia specifications of RADIX POLYGALAE PREPARATA are：Extracting liquorice, plus suitable quantity of water decoct soup, remove slag, and add net polygala, use slow fire Boil to soup and exhaust, take out, dry.

The concocting method States Pharmacopoeia specifications of honey-made mulberry bark are：Root bark of white mulberry silk is taken, method (appendix II D) is processed according to honey and fries to tack-free.

The concocting method States Pharmacopoeia specifications of sweet tussilago are：Take net tussilago, according to honey process method (appendix II D) fried with mulse to It is tack-free.

It can be seen that, the processing procedure of above-mentioned medicinal material, though pharmacopeia has regulation, without it is specific process parameter as add refined honey amount, Frying temperature, frying time etc., the judgement of concocting process and processing degree are influenceed larger by subjective factor, due to technological parameter The selected quality for directly affecting medicinal material, so the quality of medicinal material that different parameters are processed often has larger difference, clinical efficacy is difficult To ensure.

The content of the invention

The present invention is directed to above-mentioned technical problem, enterprising in the Chinese prescription of existing treatment paracmasis COPD Row is improved there is provided a kind of Chinese medicinal capsule and preparation method for treating paracmasis COPD, is not changing original medicine On the basis of material and consumption, by the fruit of Chinese magnoliavine, the bighead atractylodes rhizome, barrenwort, peach kernel, semen armeniacae amarae, the tuber of stemona, polygala, the root bark of white mulberry and coltsfoot Flower is processed, and changes drug effect, and reaches the purpose of Synergistic with the medicinal material of other in prescription, reduces the dosage and use of patient The medicine time, and honey can flavoring moistening lung, make the effect and mouthfeel of this Chinese medicinal capsule more preferably.

The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of paracmasis COPD for the treatment of Chinese medicinal capsule, is made up of the raw material of following parts by weight：

55 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 37 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 37 parts of Poria cocos, 55 parts of Herba Epimedii Preparata, 74 parts of the Radix Astragali, 60 parts of gekko, Soviet Union 37 parts of wood, 37 parts of stir-baked SEMEN PERSICAE, 55 parts of earthworm, 37 parts of semen armeniacae amarae of stir-fry, sweet 55 parts of the tuber of stemona, 37 parts of cordate houttuynia, 37 parts of bulbus fritillariae cirrhosae, system are remote 37 parts of will, 37 parts of honey-made mulberry bark, 37 parts of the tuber of dwarf lilyturf, 37 parts of cicada slough, 37 parts of radix glycyrrhizae, 37 parts of Chinese yam and sweet 37 parts of tussilago, wherein,

The processing procedure of the steamed FRUCTUS SCHISANDRAE with vinegar：

The fruit of Chinese magnoliavine is added in rice vinegar, the addition of rice vinegar is the 25% of the fruit of Chinese magnoliavine, is mixed thoroughly, 2~3h of vexed profit, 100 DEG C of steamings 2~3h is made, steams to black, dries to water content 8~10%, taking-up is cooled, and produces steamed FRUCTUS SCHISANDRAE with vinegar；

The processing procedure of the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add wheat bran, mix thoroughly, rub scattered, slow fire produces honey towards to tack-free Wheat bran is processed, the addition of refined honey is the 35% of wheat bran weight；

3) honey wheat bran is sprinkled into hot pot, adds the bighead atractylodes rhizome when smoldering, 110 DEG C~130 DEG C frying 10min~16min, Fry to yellowish-brown, effusion burnt odor gas, take out, weed out honey wheat bran, produce stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, the addition of the honey wheat bran is white The 12% of art；

The processing procedure of the Herba Epimedii Preparata：

Suet oil heating fusing is taken, barrenwort chopping is added in suet oil, and 150 DEG C are fried to uniform glossy, are taken out, are put Cool, the addition of the suet oil is the 30% of barrenwort weight, and the suet oil is the fat oil of sheep；

The processing procedure of the stir-baked SEMEN PERSICAE：

Peach kernel is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keeps boiling 5 minutes, then by peach Benevolence is placed in cold water and pulled out at once, removes kind of a skin, is fried with slow fire to yellow, produces stir-baked SEMEN PERSICAE；

It is described to fry amygdalate processing procedure：

Semen armeniacae amarae is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keep boiling 5 minutes, then will Semen armeniacae amarae is placed in cold water and pulled out at once, removes kind of a skin, is fried with slow fire to yellow, produces stir-fry semen armeniacae amarae；

The processing procedure of the sweet tuber of stemona：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add the vexed profit 35min~45min of the tuber of stemona, the tuber of stemona is taken out and puts hot pot It is interior, 110 DEG C~130 DEG C 12~15min of frying, to tack-free, tuber of stemona surface is taken out in slightly yellow, weeds out chip, airing, i.e., The sweet tuber of stemona is obtained, the addition of refined honey is the 12.5% of tuber of stemona weight；

The processing procedure of the RADIX POLYGALAE PREPARATA：

1) extracting liquorice, is added water, and liquid level is exceeded radix glycyrrhizae face 2cm, and 20~30min of micro-boiling, pressure are kept with slow fire again after boiling Extracting juice, glycyrrhiza extract repeats 2 pressure extracting juices of the above method, merges 3 juice, as succus liquiritiae；

2) net polygala is taken, in the succus liquiritiae for adding 20~30 times of volumes, 20min~40min is cooked in 110~130 DEG C, takes Go out；

3) in 110~130 DEG C of 18~22min of frying, pour out, dry；

The processing procedure of the honey-made mulberry bark：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, root bark of white mulberry silk vexed profit is added 2-4 hours, the root bark of white mulberry is taken out and puts hot pot It is interior, 150 DEG C~180 DEG C 15~20min of frying, to tack-free, root bark of white mulberry surface is in buff, is taken out, and weeds out chip, airing, Honey-made mulberry bark is produced, the addition of refined honey is the 30% of root bark of white mulberry weight；

The processing procedure of the sweet tussilago：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add tussilago vexed profit 3-4 hours, tussilago is taken out and puts in hot pot, 110 DEG C~120 DEG C fryings, 8~10min is extremely tack-free, and tussilago surface is in buff, takes out, weeds out chip, airing is produced Honey-made mulberry bark, the addition of refined honey is the 30% of root bark of white mulberry weight.

On the basis of above-mentioned technical proposal, the present invention can also do following improvement.

Further, the processing procedure of the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add wheat bran, mix thoroughly, rub scattered, slow fire produces honey towards to tack-free Wheat bran is processed, the addition of refined honey is the 35% of wheat bran weight；

3) honey wheat bran is sprinkled into hot pot, the bighead atractylodes rhizome is added when smoldering, 120 DEG C of frying 13min are fried to yellowish-brown, ease Discharge of the coke fragrance, takes out, weeds out honey wheat bran, produces stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, and the addition of the honey wheat bran is the 12% of the bighead atractylodes rhizome.

Further, the processing procedure of the sweet tuber of stemona：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add the vexed profit 40min of the tuber of stemona, the tuber of stemona is taken out and puts in hot pot, 120 DEG C Frying 13min, extremely tack-free, tuber of stemona surface is taken out in slightly yellow, weeds out chip, airing produces the sweet tuber of stemona, the addition of refined honey Measure as the 12.5% of tuber of stemona weight.

Further, the processing procedure of the RADIX POLYGALAE PREPARATA：

1) extracting liquorice, is added water, and liquid level is exceeded radix glycyrrhizae face 2cm, and micro-boiling 25min is kept with slow fire again after boiling, and squeezing takes Juice, glycyrrhiza extract repeats 2 pressure extracting juices of the above method, merges 3 juice, as succus liquiritiae；

2) net polygala is taken, in the succus liquiritiae for adding 25 times of volumes, 30min is cooked in 120 DEG C, is taken out；

3) in 120 DEG C of frying 20min, pour out, dry.

Further, the processing procedure of the honey-made mulberry bark：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, the vexed profit of root bark of white mulberry silk is added 3 hours, the root bark of white mulberry is taken out and puts in hot pot, 160 DEG C of frying 18min, extremely tack-free, root bark of white mulberry surface is in buff, takes out, weeds out chip, airing produces honey-made mulberry bark, is refined The addition of honey is the 30% of root bark of white mulberry weight.

Further, the processing procedure of the sweet tussilago：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, the vexed profit of tussilago is added 3.5 hours, tussilago is taken out and puts in hot pot, 115 DEG C of fryings, 9min is extremely tack-free, and tussilago surface is in buff, takes out, weeds out chip, airing produces honey-made mulberry bark, is refined The addition of honey is the 30% of root bark of white mulberry weight.

The present invention also provides a kind of preparation method of Chinese medicinal capsule as described above, including：

1) gekko, Herba Epimedii Preparata, the Radix Astragali, sweet tussilago, radix glycyrrhizae and cordate houttuynia Six-element medicinal material were crushed 80~200 respectively Mesh sieve, obtains gecko powder, Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet coltsfoot pollen, licorice powder, herba houttuyniae powder；

2) steamed FRUCTUS SCHISANDRAE with vinegar, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, Poria cocos, bush, stir-baked SEMEN PERSICAE, earthworm, stir-fry semen armeniacae amarae, the sweet tuber of stemona, bulbus fritillariae cirrhosae, system are taken Polygala, honey-made mulberry bark, the tuber of dwarf lilyturf, cicada slough, Chinese yam and sweet tussilago mixing, obtain medicinal material mixture, medicinal material mixture are added water to cook into 3 Secondary, first time amount of water is 4~6 times of medicinal material mixture weight, is decocted 1 hour, second of amount of water is medicinal material mixture weight 2~4 times of amount, are decocted 1 hour, and third time amount of water is 1~2 times of medicinal material mixture weight, is decocted 45 minutes, merges and decocts Liquid, filtration, relative density is 1.03~1.15 thick paste when filtrate is concentrated into 60 DEG C；

3) gecko powder is added into thick paste, continues to decoct 30 minutes, Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet tussilago is added Powder, licorice powder and herba houttuyniae powder, are mixed, 60 DEG C of dryings, water content is less than 9%, are ground into fine powder, load capsule, every dress 0.4g, is produced.

The pharmacological action of each Chinese medicine is as follows in the Chinese prescription of this treatment paracmasis COPD：

The fruit of Chinese magnoliavine：It is sour, it is warm-natured.Return lung, the heart, kidney channel.Function：Convergence is astringent or styptic treatment for spontaneous sweating；Nourishing generate fluid；Antitoxic heart-soothing and sedative.Main cough Void is breathed heavily；Emission；The urine quite enuresis；Endless diarrhea；Spontaneous sweating；Injury thirst；Palpitation and insomnia.Steamed FRUCTUS SCHISANDRAE with vinegar has convergence solid Puckery, nourishing generate fluid, effect of kidney calming.

The bighead atractylodes rhizome：Bitter, it is sweet, it is warm-natured.Returns spleen, stomach.Function：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive.For insufficiency of the spleen Deficiency of food, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.Rhizoma Atractylodis Macrocephalae invigorating the spleen, and stomach, it is antiabortive.For spleen eating less, Diarrhea loose stool, fetal irritability.Stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran can be used to increase strengthening the spleen and stomach effect of Chinese medicine, alleviate the scorching property of Chinese medicine, with Reach " wheat bran skin suppress cruel property do not hinder postcibal vomiting ", " wheat bran system go it is scorching and and stomach " effect.

Poria cocos：It is sweet, light, it is mild-natured.Return liver, stomach, the spleen channel.Function：Clearing damp and promoting diuresis, invigorating the spleen calming heart.For oedema oliguria, phlegm Drink feel dizzy and heart palpitations, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.

Barrenwort：Acrid, sweet, warm.Return liver and kidney channel.Function：Kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.For impotence and seminal emission, muscles and bones Impotence is soft, arthralgia pain due to rheumatism, numbness contracture；Climacteric hypertension.Herba Epimedii Preparata can strengthen the effect of warming kidney and enhancing yang.

The Radix Astragali：It is sweet, tepor；Returns spleen, lung channel.Function：Benefit defends solid table, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration, inducing diuresis for removing edema.For Treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, from juice night sweat, blood deficiency chlorosis, cloudy subcutaneous ulcer is unrestrained swollen, deficiency of vital energy oedema, interior heat Quench one's thirst.

Gekko：Taste is salty, mild-natured.Enter lung, kidney channel.Function：Invigorate the lung and the kidney, Dingchuan is stopped and coughed.Cure mainly：Consumptive disease, consumptive lung disease, breathe heavily cough, Spit blood, quench one's thirst, impotence.

Bush：It is sweet, salty, it is mild-natured.The thoughts of returning home, liver, the spleen channel.Function：Promoting blood circulation, swelling and pain relieving.For traumatic injury, bone The injury of tendon and muscle is rolled over, the stasis of blood is stagnant to swell and ache, closed dysmenorrhea, postpartum stasis, chest and abdomen shouting pain, ulcer sore pain

Peach kernel：Bitter sweet, puts down.The thoughts of returning home, liver, large intestine, lung, the spleen channel.Function：Promoting blood circulation, relaxes bowel.For Amenorrhea, pain Jing , wei lump in the abdomen lump in the abdomens, injury from falling down, dry constipation of intestines.Pyreticosis stores blood, wandering arthritis, malaria, hemotoncus pain.

Earthworm：It is salty, tremble with fear.Return liver, spleen, bladder warp.Function：Heat-clearing is calmed the frightened, and dredging collateral is relievingd asthma, diuresis.For unconsciousness due to high fever, Frightened disease is twitched, joint pain, extremity numbness, hemiplegia.Dyspnea and cough due to lung-heat, oliguria oedema；Hypertension.

Semen armeniacae amarae：Bitter, it is warm-natured.Return lung, spleen, large intestine channel.Function：Expelling phlegm and arresting coughing, relievings asthma, ease constipation, and lower gas opens numbness.Cure mainly Exogenous cough, breathes heavily full, and cough due to dryness, cold air run quickly globefish, frightened epilepsy, the obstruction of qi in the chest, dyspeptic stomachache, metrorrhagia is deaf, malnutritional scrotal edema, damp-heat gonorrhoea, Scabies, larynx numbness, dry constipation of intestines.Toxicity, eliminating phlegm and lowering adverse QI are removed after frying.

The tuber of stemona：Sweet, hardship, tepor.Return lung is passed through.Function：Gentle lung qi, cough-relieving, desinsection.Control cough due to wind-cold evil, pertussis, lung knot Core, old cough and asthma, roundworm, enterobiasis, skin mange, eczema.The sweet tuber of stemona moistens the lung and relieve the cough.

Cordate houttuynia：Bitter, cold nature.Return lung warp, bladder, large intestine channel.Function：Thermal detoxification；Removing pus and relieving carbuncle；Inducing diuresis for treating strangurtia. Control pneumonia, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange.

Bulbus fritillariae cirrhosae：It is bitter, sweet, it is slightly cold, return lung, the heart channel of Hang-Shaoyin.Function：Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, dry cough Few phlegm, deficiency of Yin overstrain cough coughs up sputum streaked with blood.

Polygala：Pungent, hardship, slightly warm in nature, the thoughts of returning home, kidney channel.Function：Tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence.Cause for breakdown of the normal physiological coordination between the heart and the kidney Insomnia and dreamful sleep, forgetful palpitation with fear is wandering, and expectoration is not well, sore swollen toxin, mastosis.

The root bark of white mulberry：It is sweet, cold in nature, return lung, the spleen channel.Function：Removing heat from lung and relieving asthma, line water detumescence.Dyspnea and cough due to lung-heat is controlled, is spitted blood, water It is swollen, tinea pedis, difficult urination.The raw root bark of white mulberry is longer than diuresis, and function of relieving cough and calming asthma is stronger after processing.

The tuber of dwarf lilyturf：Hardship, is slightly cold, return lung, the heart, small intestinl channel.Function：Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.For Tuberculosis cough, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines, pharyngeal diphtheria.

Cicada slough：It is sweet, salty, cool in nature, return lung, Liver Channel.Function：Dispelling wind and heat from the body, relieving sore-throat opens sound, promoting eruption, removing nebula, ceases wind Only convulsion.For anemopyretic cold, warm disease is from the beginning of pharyngalgia sound is mute, measles without adequate eruption, rubella itch, cataract, anxious chronic infantile convulsion, breaks wound Wind is demonstrate,proved, and nocturnal fretfulness in infants is uneasy.

Radix glycyrrhizae：It is sweet, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.Function：Tonifying spleen and stomach, Yiqi and vein recovery.It is tired for weakness of the spleen and the stomach It is idle weak, severe palpilation, intermittent pulse.

Chinese yam：It is sweet, put down.Returns spleen, lung, kidney channel.Function：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, Endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, and under band, frequent micturition, abnormal heat is quenched one's thirst.

Tussilago：Pungent, slight bitter, temperature, return lung warp.Function：Moistening lung to lower qi is relieving cough and reducing sputum.Coughed for new chronic cough, phlegm of breathing with cough It is many, overstrain cough hemoptysis.

The prescription for the treatment paracmasis COPD that the present invention is provided, the group on the basis of differential diagnosis in tcm Side, agrees with the interpretation of the cause, onset and process of an illness, diagnosis and treatment, the wherein Radix Astragali, the bighead atractylodes rhizome, Poria cocos, gekko, earthworm have invigorating qi for consolidating superficies invigorating the spleen, tonified the kidney to improve inspiration flat The work(breathed heavily is monarch drug in a prescription altogether；The fruit of Chinese magnoliavine, barrenwort, Chinese yam, bulbus fritillariae cirrhosae, the tuber of stemona, cicada slough, with ventilatining the lung and resolving phlegm, relieving cough and asthma, kidney tonifying Supporing yang work(is ministerial drug altogether；Peach kernel, bush, almond, tussilago, the root bark of white mulberry, cordate houttuynia, polygala, the tuber of dwarf lilyturf have relieving cough and reducing sputum dispel The stasis of blood, the work(of moistening lung defaecation dispersing and lowering lung-QI are adjutant altogether；Radix glycyrrhizae coordinating the drug actions of a prescription is to make medicine.All medicines play strengthening spleen and tonifying lung jointly above, Tonify the kidney to improve inspiration, ventilating the lung and resolving phlegm, relieving cough and asthma effect.This is based on righting and eliminating evil, and justice just is not hindered in eliminating evil.

Medicinal material used of the invention removes the fruit of Chinese magnoliavine, the bighead atractylodes rhizome, barrenwort, peach kernel, semen armeniacae amarae, the tuber of stemona, polygala, the root bark of white mulberry and coltsfoot Flower is outer by the present inventor's processing, and other medicinal materials are purchased from domestic regular Chinese Medicinal Materials Markets, and supplier is relevant according to country Regulation carries out impurity elimination, cleaning to medicinal material, selects level, detection etc., and carries out closing packaging, is gone out with the commercial form for meeting QS standards Sell, we directly use after being bought as finished product medicinal material.

The beneficial effects of the invention are as follows：

The selected medicament composing prescription of the present invention, on existing prescription to the fruit of Chinese magnoliavine, the bighead atractylodes rhizome, barrenwort, peach kernel, semen armeniacae amarae, the tuber of stemona, Polygala, the root bark of white mulberry and tussilago carry out Preparation process, with the dialectical compatibility of other drugs component, help, play altogether using mutually assistant Strengthening spleen and tonifying lung, tonifies the kidney to improve inspiration, and ventilatings the lung and resolving phlegm, relieving cough and asthma effect, for the treatment of paracmasis COPD, reaches To treating both principal and secondary aspect of disease.

The Chinese medicinal capsule of present invention treatment treatment paracmasis COPD is formulated reasonable, science, preparation method Simply, quality is easily controlled, produced beneficial effect has been obtained in animal pharmacodynamic experiment and long-term clinical practice Embody, and cure rate is high, uneasy to recur, have no toxic side effect.

Embodiment

The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit Determine the scope of the present invention.

Embodiment 1：Process the selection of parameter

First, the bighead atractylodes rhizome processes the selection of parameter

Document describes a variety of concocting methods of the bighead atractylodes rhizome, such as fries, soil is fried, bran is fried, bran is simmered, face is fried, salt solution is fried, wherein Bran is fried method and continued to use the most extensively, and records in version in 2015《Chinese Pharmacopoeia》.Traditionally the traditional Chinese medical science give birth to the bighead atractylodes rhizome with drying damp and strengthening spleen, profit Based on water detumescence, dry property relaxes after bran is fried, in entering by means of bran, the effect enhancing of strengthening the spleen and stomach, for incoordination between the spleen and the stomach, dysfunction of the spleen in transportation and transformation, Deficiency of food turgor, lassitude hypodynamia, exterior deficiency spontaneous perspiration, fetal irritability.Zhang Zhongyan exists《Repair thing guide》It is middle propose " wheat bran system go it is scorching and and Stomach ", stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran exactly embodies the effect of " removing scorching and and stomach ".

《Pharmacopoeia of People's Republic of China》2015 editions record for honey wheat bran rhizoma atractylodis macrocephalae, due to specific quantifiable Operating parameters, make troubles to production and Quality Control.As well known to those skilled in the art, the strengthening the spleen and stomach effect of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran is good In the bighead atractylodes rhizome, existing stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran processing procedure choice of parameters it is many using atractylenolide Ⅰ, atractylenolide, the content of atractylodes lactone III as Inspection target, using uniform design or the processing procedure of optimization of orthogonal test stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.It is countless by present inventor The secondary content for detecting atractylenolide Ⅰ in stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, atractylenolide, atractylodes lactone III and atractylone, action thing profit of going forward side by side Urine experiment finds that atractylone content is decreased after stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, and atractylodes lactone constituents content has to be raised to a certain degree, but It is gradually increasing with temperature, the reduction of atractylone content, the content of atractylodes lactone constituents, which has no, substantially to be increased, an instead relatively upper temperature water Pancake is low.Therefore, the increase of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran strengthening the spleen and stomach drug effect is probably because atractylenolide Ⅰ has stronger enhancing saliva after processing Liquid amylase activity, the effect for promoting intestinal tube absorption, adjusting function of intestinal canal, it is believed that atractylenolide Ⅰ mainly has for bighead atractylodes rhizome invigorating the spleen Composition is imitated, and the content in rhizoma atractylodis macrocephalae is apparently higher than health product, and then generate to medicative composition of relievining asthma.Present invention selection bran The purpose that rhizoma atractylodis macrocephalae processes parameter is to make bighead atractylodes rhizome strengthening the spleen and stomach effect preferably, and therefore, prior art is with atractylenolide Ⅰ, the bighead atractylodes rhizome Ester II, atractylodes lactone III are that the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran parameter that inspection target is filtered out is not particularly suited for the application.

Also, present inventor has also abandoned the processing procedure that stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran is screened using the method for mathematical statistics, because The preferred value obtained for the data analysing method of its offer, can only be certain combination of experiment level used, preferred result is not Taken horizontal scope can be surmounted；In addition, clear and definite directive property can not be provided to further experiment, make experiment still band very Strong groping property color, not bery accurately.So, the convergence rate that seems when orthogonal experiment is used in preliminary screening is slow, be difficult to really Fixed number increases test number (TN) according to changing rule.Especially experiment work is loaded down with trivial details, the somewhat expensive more aobvious protrusion of situation.

The chemical composition property of the bighead atractylodes rhizome is highly unstable, is also easily converted into other material compositions, and converted product Species it is relatively more.Volatile oil is the main composition of the bighead atractylodes rhizome, and content accounts for 1.4%.Atractylone accounts for 31%- in volatile oil 61%.The composition of volatile oil is also very complicated, mainly including atractyloide, atractylone, bessisterol and glycoside thereof, palmitic acid, β- Sitosterol, also contain atractyloxide, juniper camphor, atractylenolide Ⅰ, II, III, atractylenolqide.Also containing retinoid material and 14 kinds of amino acid such as L-aminobutanedioic acid, phenylalanine, arginine, proline, isoleucine, serine.Simultaneously containing Mn, Cu, Fe, The trace elements such as Ca, Mg, K.But the main active ingredient of the bighead atractylodes rhizome is volatile oil.Present inventor sends out in long-term practice Existing, the processing temperature of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran is high, can cause volatile oil excessive loss in the bighead atractylodes rhizome, and then influence the drug effect of the bighead atractylodes rhizome.The application Inventor fries experiment by multiple bighead atractylodes rhizome bran and found, processes frying temperature when bran is fried and preferably controls, at 110 DEG C~130 DEG C, both may be used Processing purpose is reached, the loss of volatile oil in the bighead atractylodes rhizome is avoided that again, is broken《Pharmacopeia》Middle stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran is no can specifically to be quantified Operating parameters defect.

Influence the processing factor of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, in addition to above-mentioned processing temperature factor, frying time, the addition of wheat bran Determine the conversion of volatile oil component.The present inventor has carried out multigroup contrast test in the research of early stage, now from substantial amounts of reality Test in data and pick out several groups of representative data, illustrate to process influence of the parameter to strengthening the spleen and stomach effect.

Experiment is divided into 5 groups, first group, second group and the 3rd group and selected for present inventor from substantial amounts of experimental data Go out several groups of representative data, it is equal that contrast groups are that prior art is passed through using atractylenolide Ⅰ, II, III content as inspection target The processing procedure for the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran that even design method preferably goes out, blank group is used as control.

Honey is purchased from commercially available honey.

Chinese ephedra is feverfew bighead atractylodes rhizome Atractylodes macrocephala Koidz. dry rhizome.

Male SD rat, body weight 180g~220g.

Concocting method：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced, it is now full Pot plays flake bubble, and hand is twisted with the fingers there is no long white silk to occur between toughness, two fingers.

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add wheat bran, mix thoroughly, rub scattered, slow fire produces honey towards to tack-free Wheat bran is processed, the addition of refined honey is the 35% of wheat bran weight.

3) honey wheat bran is sprinkled into hot pot, the bighead atractylodes rhizome is added when smoldering, the time as defined in frying, is fried to yellowish-brown, ease Discharge of the coke fragrance, takes out, weeds out honey wheat bran, produce stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.Frying temperature, time, the addition reference table 1 of wheat bran.

The measurement of frying temperature surveys temperature in pot using TM902C formula temperature enumeration, due to the more difficult control of frying temperature, real It is to be regulated and controled by lowering firepower or truce etc. in testing, each temperature levels control is in the range of ± 5 DEG C.

Take SD rats 50, stochastic averagina is divided into 4 groups, by body weight, sex equilibrium be divided into the 1st group, the 2nd group, the 3rd group, it is right Than group and blank group, every group 10.Water is can't help in 12h fasting before experiment, and each group rat is put into metabolic cage, records 3h accumulation Urine volume, then each administration group gastric infusion, blank group gives same volume physiological saline.Rat is put back into metabolism immediately after administration Cage, records 3h accumulation urine volume, and urine volume before administration is subtracted with urine volume after administration, is recorded as total volume of urine, repeats 6d.Refer to table 1.

The each group dosage of table 1, processing parameter, amount of drinking water and tatol emiction quantity result

As a result show, each processed product can increase rat urine amount, wherein, prior art is using atractylodes lactone content as investigation The effect for the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran " subtract ketone and subtract dry, increase ester synergy " that the processing procedure that index preferably goes out is processed is not so good as the application processing procedure The stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran of preparation, illustrates that the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran processing parameter that prior art is provided is not suitable for the application, the present inventor A kind of new stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran processing procedure is proposed on the basis of many experiments, is creative.

2nd, the fruit of Chinese magnoliavine processes the selection of parameter

Now there are some researches show, the fruit of Chinese magnoliavine increases its convergent effect after vinegar system, with restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, Kidney calming；Breathed heavily for void of coughing long, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, Palpitation and insomnia.There are the concocting methods such as steaming, vinegar steaming, wine steaming, mulse steaming now, wherein vinegar preparation method is continued to use most wide.

Present inventor is had found, the fruit of Chinese magnoliavine is added in rice vinegar, and the addition of rice vinegar is the 25% of the fruit of Chinese magnoliavine, is mixed thoroughly, 2~3h of vexed profit, 100 DEG C steam 2~3h, steam to black, dry to water content 8~10%, its schizandrin and fruit of Chinese magnoliavine second Cellulose content is higher.

3rd, the tuber of stemona processes the selection of parameter

Now there are some researches show the raw tuber of stemona is slightly poisonous, there is certain excitant to intestines and stomach.It then becomes necessary to be processed. Tuber of stemona chemical composition species is various, is generally divided into two classes, including alkaloid and non-alkaloid constituents.Current Stemona alkaloids are Through being separated more than 70 kinds, mainly include:Protostermonine type, thin flower tuber of stemona alkaline, this is for peaceful alkaline, Radix stemonae japonicae alkaline, right Leaf tuber of stemona alkaline, mixed type etc..Honey processs Stemona alkaloids and there is significant difference compared with health product alkaloid antitussive action, and honey processs product Alkaloid antitussive activity is better than health product alkaloid.

Present inventor is had found, tuber of stemona honey is processed, using frying after first vexed profit, and using vexed profit time 35min~ 45min, 110 DEG C~130 DEG C 12~15min of frying, can farthest retain its alkaloid.

4th, barrenwort processes the selection of parameter

Suet oil derives from bovid goat Capra hircusLinnaeus or sheep Ovis aries Linnaeus Fat oil.Suet oil contains the fatty acid compositions such as oleic acid, palmitic acid and stearic acid.The composition of suet fatty acid oil constituents Influenceed with content by factors such as the kinds, sex and position of sheep, quality has different, cause the quality good and the bad of Herba Epimedii Preparata Differ.And when barrenwort is processed, the addition and frying temperature of suet oil can also influence the quality of Herba Epimedii Preparata.

The present inventor carries out big gun under different additions, different temperatures to goat fat oil and Mianyang fat oil to barrenwort System, investigates the influence to mice with kidney-yang deficiency body weight, shell temperature and autonomic activities number of times, specific experiment step reference literature (ratio Compared with the warm kidney sun effect of the oily Herba Epimedii Preparata of suet with different qualities), following processing procedure is finally determined：

Suet oil heating fusing is taken, barrenwort chopping is added in suet oil, and 150 DEG C are fried to uniform glossy, are taken out, are put Cool, the addition of the suet oil is the 30% of barrenwort weight, and the suet oil is the fat oil of sheep.

The barrenwort handled using above-mentioned processing procedure, hence it is evident that improve the weight of animals and mitigate, temperature decline, enhancing is autonomous living Kinetic force, improves the effect of barrenwort warming kidney and enhancing yang.

5th, peach kernel processes the selection of parameter

Now there are some researches show the chemical composition of peach kernel includes amarogentin, various greases (such as:Neutral fats, glycolipid matter, phosphorus Fat etc.), volatile oil, carbohydrate (such as:Glucose, sucrose etc.), protein, amino acid, vitamin B1, olein, bitter apricot Benevolence enzyme, allantoinase, essential oil, and its toxicity such as trace element Fe, Mn, Mg have close pass with active ingredient amarogentin therein System.Amarogentin chemical name:Benzene hydroxyl second cyanogen-β-D-Glucose glycosides.Itself is nontoxic, but makees in the decomposition of emulsin etc. There is severe toxicity with the hydrogen cyanide (HCN) of lower generation.

Present inventor's research finds that emulsin is just inactivated more than 80 DEG C, and amarogentin solubility in water It is larger, it can also be hydrolyzed in water, therefore, semen armeniacae amarae is poured into and boiling 5 minutes is kept in 100 DEG C of boiling water by the application, that is, ensure that The inactivation of emulsin, reduces dissolving and hydrolysis of the amarogentin in water as far as possible again.The addition of peach kernel is set to by the application / 10th of boiling water volume, are that because adding too many peach kernel boiling water water temperature drop can be made too many, not reaching loses emulsin Effect living.Semen armeniacae amarae is gone after kind of skin, more conducively frying when processing to peach kernel, fried to yellow, at utmost retained with slow fire Amarogentin.Peach kernel after being processed through the present invention, uses with other drug matchings in this prescription, has no toxic side effect.

6th, semen armeniacae amarae processes the selection of parameter

Now there are some researches show the amarogentin contained in semen armeniacae amarae produces hydrogen cyanide after being hydrolyzed through emulsin, suppresses to exhale Suction maincenter, produces antitussive action, and semen armeniacae amarae toxicity and pharmacodynamic action are proportionate, its poison of the strong semen armeniacae amarae of function of relieving cough and calming asthma Property it is also strong, the key of processing is the activity for suppressing emulsin, preserves amarogentin and is not hydrolyzed by emulsin.The present inventor causes Power looks for equalization point in the concocting method for looking for semen armeniacae amarae greatest treatment efficacy and minimum toxicity between toxicity and validity, realizes peace The unification of full property and validity.

Present inventor's research finds that emulsin is just inactivated more than 80 DEG C, and amarogentin solubility in water It is larger, it can also be hydrolyzed in water, therefore, semen armeniacae amarae is poured into and boiling 5 minutes is kept in 100 DEG C of boiling water by the application, that is, ensure that The inactivation of emulsin, reduces dissolving and hydrolysis of the amarogentin in water as far as possible again.The application sets amygdalate addition It is that because adding too many semen armeniacae amarae boiling water water temperature drop can be made too many, not reaching makes semen armeniacae amarae for 1/10th of boiling water volume The effect of enzyme inactivation.Semen armeniacae amarae is gone after kind of skin, more conducively frying when to amygdalate processing, fried with slow fire to yellow, maximum journey Degree retains amarogentin.Semen armeniacae amarae after being processed through the present invention, is used with other drug matchings in this prescription, nontoxic secondary work With.

7th, polygala processes the selection of parameter

Polygala belongs to one of conventional Traditional Chinese medicine for tranquilization, its bitter, raw to use halberd people's throat, clinical to be used as medicine after processing.《This crop smothering Profit》Described in:" glycyrrhiza decoction stain one night because hardship is descending, delays it with sweet, is allowed to hair, day of filtering exposes dry." main component in polygala It is polygalin, polygala alkali, polygalite etc..Wherein, polygalin easily stimulates gastric mucosa and causes nausea and vomiting, stimulates kidney And influence renal function.Radix glycyrrhizae is sweet, the function with the toxicity for conciliating all medicines.Shown according to pharmacological testing, it is remote with succus liquiritiae system Will can subtract its dry property, relax the property of medicine, the toxic side effect of polygala is mitigated or eliminated, with reach invigorate the spleen and benefit qi, the purpose of tranquilize the mind and promote the intelligence.

Present inventor's research finds that RADIX POLYGALAE PREPARATA requires that succus liquiritiae must be exhausted by polygala.Found by test of many times, Net polygala is added in the succus liquiritiae of 20~30 times of volumes, and 20min~40min are cooked in 110~130 DEG C, is taken out, and in 110~ 130 DEG C of 18~22min of frying, are poured out, and are dried, and its presenegenin content will be significantly larger than other technological parameters.

Embodiment 2

Steamed FRUCTUS SCHISANDRAE with vinegar 55g, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran 37g, Poria cocos 37g, Herba Epimedii Preparata 55g, Radix Astragali 74g, gekko 60g, bush 37g, Stir-baked SEMEN PERSICAE 37g, earthworm 55g, stir-fry semen armeniacae amarae 37g, sweet tuber of stemona 55g, cordate houttuynia 37g, bulbus fritillariae cirrhosae 37g, RADIX POLYGALAE PREPARATA 37g, honey Sang Bai Skin 37g, tuber of dwarf lilyturf 37g, cicada slough 37g, radix glycyrrhizae 37g, Chinese yam 37g and sweet tussilago 37g.

The processing procedure of the steamed FRUCTUS SCHISANDRAE with vinegar：

The fruit of Chinese magnoliavine is added in rice vinegar, the addition of rice vinegar is the 25% of the fruit of Chinese magnoliavine, is mixed thoroughly, 2~3h of vexed profit, 100 DEG C of steamings 2~3h is made, steams to black, dries to water content 8~10%, taking-up is cooled, and produces steamed FRUCTUS SCHISANDRAE with vinegar；

The processing procedure of the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add wheat bran, mix thoroughly, rub scattered, slow fire produces honey towards to tack-free Wheat bran is processed, the addition of refined honey is the 35% of wheat bran weight；

3) honey wheat bran is sprinkled into hot pot, adds the bighead atractylodes rhizome when smoldering, 140 DEG C~160 DEG C frying 10min~15min, Fry to yellowish-brown, effusion burnt odor gas, take out, weed out honey wheat bran, the addition of the wheat bran is the 12% of the bighead atractylodes rhizome；

The processing procedure of the Herba Epimedii Preparata：

Suet oil heating fusing is taken, barrenwort chopping is added in suet oil, and 150 DEG C are fried to uniform glossy, are taken out, are put Cool, the addition of the suet oil is the 30% of barrenwort weight, and the suet oil is the fat oil of sheep；

The processing procedure of the stir-baked SEMEN PERSICAE：

Peach kernel is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keeps boiling 5 minutes, then by peach Benevolence is placed in cold water and pulled out at once, removes kind of a skin, is fried with slow fire to yellow, produces stir-baked SEMEN PERSICAE；

It is described to fry amygdalate processing procedure：

Semen armeniacae amarae is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keep boiling 5 minutes, then will Semen armeniacae amarae is placed in cold water and pulled out at once, removes kind of a skin, is fried with slow fire to yellow, produces stir-fry semen armeniacae amarae；

The processing procedure of the sweet tuber of stemona：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add the vexed profit 35min~45min of the tuber of stemona, the tuber of stemona is taken out and puts hot pot It is interior, 110 DEG C~130 DEG C 12~15min of frying, to tack-free, tuber of stemona surface is taken out in slightly yellow, weeds out chip, airing, i.e., The sweet tuber of stemona is obtained, the addition of refined honey is the 12.5% of tuber of stemona weight；

The processing procedure of the RADIX POLYGALAE PREPARATA：

1) extracting liquorice, is added water, and liquid level is exceeded radix glycyrrhizae face 2cm, and 20~30min of micro-boiling, pressure are kept with slow fire again after boiling Extracting juice, glycyrrhiza extract repeats 2 pressure extracting juices of the above method, merges 3 juice, as succus liquiritiae；

2) net polygala is taken, in the succus liquiritiae for adding 20~30 times of volumes, 20min~40min is cooked in 110~130 DEG C, takes Go out；

3) in 110~130 DEG C of 18~22min of frying, pour out, dry；

The processing procedure of the honey-made mulberry bark：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, root bark of white mulberry silk vexed profit is added 2-4 hours, the root bark of white mulberry is taken out and puts hot pot It is interior, 150 DEG C~180 DEG C 15~20min of frying, to tack-free, root bark of white mulberry surface is in buff, is taken out, and weeds out chip, airing, Honey-made mulberry bark is produced, the addition of refined honey is the 30% of root bark of white mulberry weight；

The processing procedure of the sweet tussilago：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, to water content For 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, refined honey is produced；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add tussilago vexed profit 3-4 hours, tussilago is taken out and puts in hot pot, 110 DEG C~120 DEG C fryings, 8~10min is extremely tack-free, and tussilago surface is in buff, takes out, weeds out chip, airing is produced Honey-made mulberry bark, the addition of refined honey is the 30% of root bark of white mulberry weight.

Preparation method：

1) gekko, Herba Epimedii Preparata, the Radix Astragali, sweet tussilago, radix glycyrrhizae and cordate houttuynia Six-element medicinal material were crushed 80~200 respectively Mesh sieve, obtains gecko powder, Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet coltsfoot pollen, licorice powder, herba houttuyniae powder；

2) steamed FRUCTUS SCHISANDRAE with vinegar, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, Poria cocos, bush, stir-baked SEMEN PERSICAE, earthworm, stir-fry semen armeniacae amarae, the sweet tuber of stemona, bulbus fritillariae cirrhosae, system are taken Polygala, honey-made mulberry bark, the tuber of dwarf lilyturf, cicada slough, Chinese yam and sweet tussilago mixing, obtain medicinal material mixture, medicinal material mixture are added water to cook into 3 Secondary, first time amount of water is 4~6 times of medicinal material mixture weight, is decocted 1 hour, second of amount of water is medicinal material mixture weight 2~4 times of amount, are decocted 1 hour, and third time amount of water is 1~2 times of medicinal material mixture weight, is decocted 45 minutes, merges and decocts Liquid, filtration, relative density is 1.03~1.15 thick paste when filtrate is concentrated into 60 DEG C；

3) gecko powder is added into thick paste, continues to decoct 30 minutes, Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet tussilago is added Powder, licorice powder and herba houttuyniae powder, are mixed, 60 DEG C of dryings, water content is less than 9%, are ground into fine powder, load capsule, every dress 0.4g, is produced.

Clinical report：

1 data and method

1.1 general information：

It is asthma section of Xianghe Tracheitis and Asthma Hospital inpatient, man 50, female 50 to select 100；Age 20~65 Year, average (44.6 ± 8.4) year；The course of disease 6~30 years, average (9.1 ± 4.2) year.

1.2 application method

The capsule that embodiment 2 is made is taken, 6 every time, 3 times a day, is continuously taken 80 days.

2nd, diagnostic criteria：

Doctor trained in Western medicine diagnoses reference《WS 318-2010 diagnosis of chronic obstructive pulmonary disease standards》Tcm diagnosis and differentiation of symptoms and signs for classification of syndrome ginseng According to State Administration of Traditional Chinese Medicine《Disease of tcm Standardization of diagnosis and curative effect》.

2.1st, inclusive criteria：

Meet diagnosis；18 years old~65 years old age；The course of disease 4~30 years；Inpatient；I knows, and contraindication in pregnancy takes the phase Between avoid tobacco and wine and maror.

2.2nd, observation index：

With reference to 2002《New Chinese medicine guideline of clinical investigations》[4] the Syndrome Scale quantitative criteria listed, with reference to facing Symptom (cough, expectoration, laryngeal stridor, breathe heavily and suppress) seen in bed each by gently, in, again respectively based on 2 points, 4 points, 6 points, secondary disease (appetite, Bitter taste, constipation, shortness of breath) each by it is light, in, again respectively based on 1 point, 3 points, 5 points, inquiry is observed item by item before and after treatment, is calculated and is remembered Total mark is recorded, observed and recorded tongue picture, pulse condition but is not scored.

2.3rd, criterion of therapeutical effect：

Reference《New Chinese medicine guideline of clinical investigations》In disease curative effect determinate standard.It is effective：Original symptom is complete Disappear or significantly mitigate, symptom integral reduces >=70%；Effectively：Original symptom has taken a turn for the better or mitigated, and symptom integral reduction >= 30% but ＜ 70%；It is invalid：Original symptom is without improvement, symptom integral ＜ 30%.

3rd, result：

As a result show：100 patients, effective 80, effective 18, invalid 2, total effective rate 98%.

4th, model case：

Chen, man, 67 years old, Hok-lo suffered from COPD with cough, more than 10 years of expectoration, aggravated with after activity Breathe heavily and suppress 2 years, through regular western medicine treatment, do not feel any better.Come our hospital to be in hospital, the capsule 6 being made each taking embodiment 2, daily 3 It is secondary, continuously take 80 days, double pulmonary respiration changes of tune are thick after treatment, and dry moist rales disappears, and trusted subordinate is negative, and double lower limb oedema disappears, Lung capacity increases to 1800ml by 1500ml, and symptom disappears, do not recurred.

Luo, female, 50 years old, people from Shanxi suffered from COPD with cough, expectoration is breathed heavily after activity and suppressed for more than 40 years, plus Weight first quarter moon, through regular western medicine treatment, does not feel any better, comes our hospital and be in hospital, the capsule 6 being made each taking embodiment 2, daily 3 It is secondary, continuously take 80 days, symptom disappears after treatment, double pulmonary respiration changes of tune are thick, double lower limb oedema disappears, lung capacity is increased by 800ml 1500ml is added to, is not recurred.

The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.

Claims (2)

1. a kind of Chinese medicinal capsule for treating paracmasis COPD, it is characterised in that by the raw material of following parts by weight It is made：

55 parts of steamed FRUCTUS SCHISANDRAE with vinegar, 37 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 37 parts of Poria cocos, 55 parts of Herba Epimedii Preparata, 74 parts of the Radix Astragali, 60 parts of gekko, bush 37 Part, 37 parts of stir-baked SEMEN PERSICAE, 55 parts of earthworm, 37 parts of semen armeniacae amarae of stir-fry, sweet 55 parts of the tuber of stemona, 37 parts of cordate houttuynia, 37 parts of bulbus fritillariae cirrhosae, RADIX POLYGALAE PREPARATA 37 Part, 37 parts of honey-made mulberry bark, 37 parts of the tuber of dwarf lilyturf, 37 parts of cicada slough, 37 parts of radix glycyrrhizae, 37 parts of Chinese yam and sweet 37 parts of tussilago, wherein,

The processing procedure of the steamed FRUCTUS SCHISANDRAE with vinegar：

The fruit of Chinese magnoliavine is added in rice vinegar, the addition of rice vinegar is the 25% of the fruit of Chinese magnoliavine, is mixed thoroughly, vexed profit 2~3h, 100 DEG C steam 2~ 3h, steams to black, dries to water content 8~10%, taking-up is cooled, and produces steamed FRUCTUS SCHISANDRAE with vinegar；

The processing procedure of the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, be to water content 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, produce refined honey；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add wheat bran, mix thoroughly, rub scattered, slow fire produces honey and process bran towards to tack-free Skin, the addition of refined honey is the 35% of wheat bran weight；

3) honey wheat bran is sprinkled into hot pot, the bighead atractylodes rhizome is added when smoldering, 120 DEG C of frying 13min fry burnt to yellowish-brown, effusion Fragrance, takes out, weeds out honey wheat bran, produces stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, and the addition of the honey wheat bran is the 12% of the bighead atractylodes rhizome；

The processing procedure of the Herba Epimedii Preparata：

Suet oil heating fusing is taken, barrenwort chopping is added in suet oil, and 150 DEG C are fried to uniform glossy, are taken out, are cooled, institute The addition for stating suet oil is the 30% of barrenwort weight, and the suet oil is the fat oil of sheep；

The processing procedure of the stir-baked SEMEN PERSICAE：

Peach kernel is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keeps boiling 5 minutes, then peach kernel is put Pulled out at once in cold water, remove kind of a skin, fried with slow fire to yellow, produce stir-baked SEMEN PERSICAE；

It is described to fry amygdalate processing procedure：

Semen armeniacae amarae is added in 100 DEG C of boiling water, addition is 1/10th of boiling water volume, keeps boiling 5 minutes, then by bitter apricot Benevolence is placed in cold water and pulled out at once, removes kind of a skin, is fried with slow fire to yellow, produces stir-fry semen armeniacae amarae；

The processing procedure of the sweet tuber of stemona：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, be to water content 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, produce refined honey；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, add the vexed profit 40min of the tuber of stemona, the tuber of stemona is taken out and puts in hot pot, 120 DEG C of fryings 13min, extremely tack-free, tuber of stemona surface is taken out in slightly yellow, weeds out chip, airing produces the sweet tuber of stemona, and the addition of refined honey is The 12.5% of tuber of stemona weight；

The processing procedure of the RADIX POLYGALAE PREPARATA：

1) extracting liquorice, is added water, and liquid level is exceeded radix glycyrrhizae face 2cm, and micro-boiling 25min is kept with slow fire again after boiling, and presses extracting juice, sweet Careless slag repeats 2 pressure extracting juices of the above method, merges 3 juice, as succus liquiritiae；

2) net polygala is taken, in the succus liquiritiae for adding 25 times of volumes, 30min is cooked in 120 DEG C, is taken out；

3) in 120 DEG C of frying 20min, pour out, dry；

The processing procedure of the honey-made mulberry bark：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, be to water content 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, produce refined honey；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, the vexed profit of root bark of white mulberry silk is added 3 hours, the root bark of white mulberry is taken out and puts in hot pot, 160 DEG C frying 18min, to tack-free, root bark of white mulberry surface is in buff, takes out, weeds out chip, airing produces honey-made mulberry bark, refined honey Addition be root bark of white mulberry weight 30%；

The processing procedure of the sweet tussilago：

1) honey is put in pot, 116~118 DEG C is first heated to moderate heat, then micro-boiling is kept with slow fire heating, be to water content 10%~13%, supernatant foam and wax are dragged for, then impurity is filtered off with sieve sieve or gauze, produce refined honey；

2) refined honey is taken, distilled water diluting is added and mixes thoroughly, the vexed profit of tussilago is added 3.5 hours, tussilago is taken out and puts in hot pot, 115 DEG C frying, 9min, to tack-free, tussilago surface is in buff, takes out, weeds out chip, airing produces honey-made mulberry bark, refined honey Addition be root bark of white mulberry weight 30%.

2. a kind of preparation method of Chinese medicinal capsule as claimed in claim 1, it is characterised in that including：

1) gekko, Herba Epimedii Preparata, the Radix Astragali, sweet tussilago, radix glycyrrhizae and cordate houttuynia Six-element medicinal material were crushed into 80~200 mesh respectively Sieve, obtains gecko powder, Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet coltsfoot pollen, licorice powder, herba houttuyniae powder；

2) take steamed FRUCTUS SCHISANDRAE with vinegar, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, Poria cocos, bush, stir-baked SEMEN PERSICAE, earthworm, stir-fry semen armeniacae amarae, the sweet tuber of stemona, bulbus fritillariae cirrhosae, system remote Will, honey-made mulberry bark, the tuber of dwarf lilyturf, cicada slough, Chinese yam and sweet tussilago mixing, obtain medicinal material mixture, medicinal material mixture are added water to cook into 3 Secondary, first time amount of water is 4~6 times of medicinal material mixture weight, is decocted 1 hour, second of amount of water is medicinal material mixture weight 2~4 times of amount, are decocted 1 hour, and third time amount of water is 1~2 times of medicinal material mixture weight, is decocted 45 minutes, merges and decocts Liquid, filtration, relative density is 1.03~1.15 thick paste when filtrate is concentrated into 60 DEG C；

3) add gecko powder into thick paste, continue to decoct 30 minutes, add Herba Epimedii Preparata powder, astragalus membranaceus powder, sweet coltsfoot pollen, sweet Grass meal and herba houttuyniae powder, are mixed, 60 DEG C of dryings, water content is less than 9%, are ground into fine powder, load capsule, and every fills 0.4g, Produce.