CN106265223A - One peptide species anti-acne skin rejuvenating facial mask and preparation method thereof - Google Patents
One peptide species anti-acne skin rejuvenating facial mask and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses peptide species anti-acne skin rejuvenating facial mask and preparation method thereof, this facial film, rich in beauty treatment polypeptide moiety, mainly includes following components: hexapeptide 9, tetrapeptide 30, antibacterial peptide, Aloe vulgaris, dairy yeast, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers 3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate.The total weight percent of hexapeptide 9, tetrapeptide 30, antibacterial peptide three kinds beauty treatment polypeptide is 10～15%.Three kinds of beauty treatment polypeptide of this facial film are the functional components that this product is main.There are some researches show that hexapeptide 9, tetrapeptide 30, antibacterial peptide have the strongest antibacterial, anti-acne effect, use this product can quickly dispel facial acne and life-time service can repair face pockmark.
Description
Technical field
The present invention relates to facial film field, be specifically related to peptide species anti-acne skin rejuvenating facial mask and preparation method thereof.
Background technology
Pox is being commonly called as of acne, is again " comedo ", " skin sore " or " acne ", is owing to hair follicle and sebaceous gland are blocked, sent out
The scorching a kind of dermatosis caused.During adolescence, internal hormone can grow by stimulating hair, promotes smegma more heavy wool
Therefore fat, hair and sebaceous gland pile up many materials, make oils and fats and antibacterial attachment, cause the reaction of red swelling of the skin.Due to this
Symptom is common in youth of both sexes, so being referred to as " comedo ".
The method of existing anti-acne has a variety of, 1, as laser therapy comedo method be to be contaminated by the high intensity of specific wavelength
Material laser irradiates, energy rapid damage propanoic acid comedo bacillus, effectively suppresses bacterial reproduction, eliminates its stimulation to organizing and destruction
Effect, but the effect of laser therapy is too strong, and also simply physical method destroys pox, it is impossible to fundamentally anti-acne；2, profit
Composition anti-acne is mixed with plant with some natural plant components, Chinese medicinal ingredients or Chinese medicines such as Aloe, Fructus Cucumidis sativi, lavandula angustifoliaes, existing
This anti-acne method safety, regulation of skin oils and fats can be played thus the effect of fundamentally anti-acne, but often use this
When planting natral plant ingredients anti-acne, the marking after time length, anti-acne is difficult to remove completely；3, utilize salicylic acid, Bo Nisong, fill in
Some Western medicine such as meter Song remove pox, and the side effect of Western medicine is the strongest.
Polypeptide is formed (50 aminoacid hereinafter referred to as polypeptide, 50 aminoacid are referred above to albumen) by aminoacid,
It is the middle hydrolyzate of protein, is also the constituent of human body cell.Numerous studies show, protein is the completeest after taking in
All-hydrolytic becomes aminoacid, and major part is absorbed with the form of peptide, the most also finds, the absorbed speed of polypeptide is than the ammonia with composition
Base acid wants fast.
Polypeptide is mainly endogenous polypeptide or other natural polypeptidess, and its structure understands, mechanism of action clear and definite, quality control water
Flush and be bordering on traditional small molecule chemicals, and close to albumen in activity, gathered the excellent of conventional chemicals and albumen
Point.
Beauty treatment polypeptide is the polypeptide that a class has beauty functions.The condensation substance being made up of multiple aminoacid is (the most common
Beauty treatment polypeptide is 2-10 amino condensation compound), but it is because amino acid classes, sequence difference, its function is entirely different.
Beauty treatment polypeptide because human body is not injured, effect is obvious, mechanism of action is clear, the most applied more than 20
Year, all adding (Estee Lauder, perfume (or spice) how, Christian Dior, Lancome etc.), and China is the most at the early-stage for a lot of famous products, and market should
Consumption is also little, and a lot of products are the most all to propagandize；But along with progressively adding of state food pharmaceuticals administration general bureau's facial film supervision
By force, market is bound to progressively specification.
Summary of the invention
The present invention has considered shortcoming and the deficiency that existing anti-acne technology exists, and it is an object of the invention to carry
Go out that a kind of anti-acne effect is more preferable, responding time is shorter, natural safe polypeptide anti-acne skin rejuvenating facial mask.This polypeptide anti-acne skin rejuvenating facial mask
With multiple antibacterial polypeptide as main active, play synergism, play antibacterial, the purpose of antiinflammatory, be finally reached anti-acne
Effect.It is a further object to provide the preparation method of above-mentioned polypeptide anti-acne skin rejuvenating facial mask.
The present invention to achieve these goals, by the following technical solutions:
One peptide species anti-acne skin rejuvenating facial mask, weight percentage, including following components:
As preferably, said composition by mass percentage, the component including following:
As preferably, said composition includes following component by mass percentage:
As further preferably, described hexapeptide-9, tetrapeptide-30, antibacterial peptide three kinds beauty treatment polypeptide total weight percent 10
～15%.
As further preferably, described hexapeptide-9, tetrapeptide-30, antibacterial peptide three kinds beauty treatment polypeptide purity at 95-99%.
The present invention is in order to realize above-mentioned second purpose, by the following technical solutions:
The preparation method of one peptide species anti-acne skin rejuvenating facial mask, comprises the following steps:
1) by former to water, Aloe vulgaris, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum, stearic acid, Laurel
Spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate add in retort, open stirring, are heated to 75～80 DEG C, stirring
It is uniformly dispersed；
2) cooling circulating water is opened, stirring cooling, when temperature is down to 40～45 DEG C, dairy yeast is added in retort, homogenizing 1
Minute, stirring and dissolving is complete；
3) continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide are added in retort, homogenizing 2-3 minute,
Stirring and dissolving is complete, terminates.
Further object is that the effect providing polypeptide anti-acne skin rejuvenating facial mask in terms of antibacterial, anti-acne.
The present invention also provides for polypeptide anti-acne skin rejuvenating facial mask to be had and dispels facial acne and life-time service can repair the work of face pockmark
With.
In the present invention, three peptide species are main additive.Wherein:
Hexapeptide-9 is a kind of beauty treatment polypeptide using solid-phase synthesis to synthesize, be characterized in purity high, non-stimulated to human body,
Clear mechanism, hexapeptide-9 has good effect dispelling pox India side face, additionally, hexapeptide-9 also to have promotion dermal collagen raw
The regeneration of one-tenth, true epidermis articulamentum, promoting epidermization and effect of differentiation[1]。
Tetrapeptide-30 is a kind of beauty treatment polypeptide using solid-phase synthesis to synthesize, and is characterized in that purity is high, stingless to human body
Sharp, beauty treatment clear mechanism, tetrapeptide-30 has antiinflammatory, repairing effect, can significantly reduce the damage of acne[2,3]。
Antibacterial peptide is a kind of polypeptide using solid-phase synthesis to synthesize, and is characterized in having antibacterium, fungus, virus etc. many
Plant biological function, product for resolving poxes has good application prospect[4]。
Component used in facial film of the present invention, can commercially buy, belong to existing product.
Present invention have the advantage that
1) that this product adds is antibacterial, antiinflammatory polypeptide moiety is higher, and formula is contained within the natural extracts such as Aloe vulgaris,
There is quick flat and comfort the features such as skin, efficient moisturizing, skin care nourishing.After using 7 days continuously, small pox substantially diminishes, skin becomes
Smooth, fine and smooth.
2) polypeptide anti-acne skin rejuvenating facial mask product safety of the present invention, effectively；And preparation method is simple, process stabilizing, can be applicable.
Accompanying drawing explanation
The change of recipient site L* value during the use of Fig. 1: polypeptide anti-acne skin rejuvenating facial mask
Detailed description of the invention
List each composition weight percentage of polypeptide anti-acne skin rejuvenating facial mask embodiment 1 embodiment 3 of the present invention with table 1 below to contain
Amount
The preparation method of aforementioned polypeptides anti-acne skin rejuvenating facial mask, comprise the following steps: by water, Aloe vulgaris, butanediol, glycerol,
Hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene second
Ester adds in retort, opens stirring, is heated to 75～80 DEG C, and dispersed with stirring is uniform；
Open cooling circulating water, stirring cooling, when temperature is down to 40～45 DEG C, dairy yeast is added in retort, homogenizing 1 point
Clock, stirring and dissolving is complete；Continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide are added in retort, all
Matter 2-3 minute, stirring and dissolving is complete, terminates.
List each composition weight percentage of polypeptide anti-acne skin rejuvenating facial mask embodiment 4 embodiment 6 of the present invention with table 2 below to contain
Amount
The preparation method of aforementioned polypeptides anti-acne skin rejuvenating facial mask, comprise the following steps: by water, Aloe vulgaris, butanediol, glycerol,
Hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene second
Ester adds in retort, opens stirring, is heated to 70～75 DEG C, and dispersed with stirring is uniform；
Open cooling circulating water, stirring cooling, when temperature is down to 40～42 DEG C, dairy yeast is added in retort, homogenizing 1 point
Clock, stirring and dissolving is complete；Continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide are added in retort, all
Matter 2-3 minute, stirring and dissolving is complete, terminates.
List each composition weight percentage of polypeptide anti-acne skin rejuvenating facial mask embodiment 7 embodiment 9 of the present invention with table 3 below to contain
Amount
The preparation method of aforementioned polypeptides anti-acne skin rejuvenating facial mask, comprise the following steps: by water, Aloe vulgaris, butanediol, glycerol,
Hyaluronate sodium, squalane, tocopherol, Xanthan gum are former, stearic acid, Laurel spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, oxybenzene second
Ester adds in retort, opens stirring, is heated to 75～78 DEG C, and dispersed with stirring is uniform；
Open cooling circulating water, stirring cooling, when temperature is down to 40～42 DEG C, dairy yeast is added in retort, homogenizing 1 point
Clock, stirring and dissolving is complete；Continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide are added in retort, all
Matter 2-3 minute, stirring and dissolving is complete, terminates.
Properties of product evaluation test of the present invention is as follows:
One, embodiment 1-9 carries out anti-acne effect test:
1, tester selects: select 180 slight, moderate acne patients, age 18-35 year between, be divided into 9 groups, often organize 20
People.
2, using method: once a day, applies face 30 minutes by the Deacne pack of the present invention after face cleaning, then cleans with warm water
Totally.Product uses one month continuously.
3, criterion and result (table 4):
Recovery from illness: acne disappears substantially；
Effective: acne is obviously improved, remain a small amount of acne, pimple；
Effective: acne has a certain degree of improvement；
Invalid: without improving
Table 4 anti-acne experimental result
Result: in 180 examples, uses what product of the present invention fully recovered to account for 17%, and effective accounts for 44%, effectively accounts for 34%, always
Total efficiency is 95%, and untoward reaction occurs in none example of whole experimenters.
Two, embodiment 6 is carried out whitening effect evaluation
The polypeptide anti-acne skin rejuvenating facial mask provided in this experimental selection embodiment 6 is tested.
Select 30 ages 23～35 years old healthy women, measure and record face skin color, then provide tested
Film, study subject uses polypeptide anti-acne skin rejuvenating facial mask sample continuously.After using 7d, 14d, 21d, 30d continuously, then measure each effect
Index.Inquiry volunteer feels and with or without allergic phenomena etc. after using given the test agent simultaneously, records contrast before and after self.?
After using before facial film 1d and using, 7d, 14d, 21d, 30d utilize Lab colorimeter system spectrophotometer to measure the change of skin color
Change, follow-on test 3 times, average.Data process and use spss statistical software to carry out paired t-test, have aobvious with P < 0.05
Write meaning.
The situation of change of recipient site skin colourity L* value before and after test: skin colourity L* value is the biggest, represents skin color
The most shallow.7d after product use, skin colourity L* value just has the trend of increase, from 14d, is just significantly greater than water before test
Flat (P < 0.05) (see Fig. 1, data are shown in Table 5), L* value uses the prolongation of time to present the trend being gradually increased along with product.
The change of recipient site L* value during the use of table 5 polypeptide anti-acne skin rejuvenating facial mask
| Time/week | Comparison | 1 | 2 | 3 | 4 |
| L* value | 55.30 | 68.20 | 77.35 | 88.70 | 90.12 |
In sum, this mask product has effect of skin whitening, bright color.
Three, embodiment 6 is carried out moisture content of skin test.
Select 20 ages 20～40 years old healthy women, measure moisture content of skin, then provide tested facial film, tested right
As using polypeptide anti-acne skin rejuvenating facial mask sample continuously.After using 1d, 3d, 7d, then measure each efficacy measures.Using tested facial film
After 1d, 3d, 7d, utilize skin moisture tester that skin moisture content is tested, record skin moisture content changing value, even
Continuous test 3 times, averages.Data process and use spss statistical software to carry out paired t-test, have notable meaning with P < 0.05
Justice.
The situation of change of recipient site water content before and after test: the numerical value of test is the biggest, represents that water content is the highest.Product makes
Using rear 1d, moisture of skin just has the trend of increase, and from 3d, before being just significantly greater than test, level (P < 0.05) (be shown in by data
Table 6), along with product uses the prolongation of time to present the trend being gradually increased.
The change of skin moisture content value between table 6 polypeptide anti-acne skin rejuvenating facial mask validity period
| Time/sky | 0 | 1 | 3 | 7 |
| Water content numerical value | 30±0.15 | 56±0.20 | 67±0.32 | 80±0.30 |
Four, polypeptide anti-acne skin rejuvenating facial mask stability test result
According to People's Republic of China's light industry standard QB/T 2872 to made containing hexapeptide-9, tetrapeptide-30, antibacterial peptide
Polypeptide anti-acne skin rejuvenating facial mask carry out sense organ, physicochemical property test, result is as shown in table 7.As shown in Table 7, polypeptide anti-acne skin care
The testing result of facial film color, turbidity, cold-resistant heat resistant test and acid-base value all meets People's Republic of China's light industry mark
The sense organ of quasi-QB/T 2872, physical and chemical index specify, show to add three kinds of quality index to polypeptide anti-acne skin rejuvenating facial mask substantially without
Impact.
Table 7 polypeptide anti-acne skin rejuvenating facial mask Detection of Stability result
| Project | Result |
| Outward appearance | Uniform liquid. free from foreign meter |
| Heat-resistant experiment | (40 ± 1) DEG C keep 24h, recover to room temperature front with test without obvious Traits change |
| Cold-resistant experiment | (5 ± 1) DEG C keep 24h, recover to room temperature front with test without obvious Traits change |
| pH | It is about 7.0 |
The polypeptide anti-acne skin rejuvenating facial mask product that example 1, embodiment 3, embodiment 5, embodiment 7, embodiment 9 are prepared, with
Existing Deacne pack product carries out Experimental comparison, and experiment condition is: 60 women of volunteer, in age 18-35 year, uses 1 every day
Secondary, use 28 days continuously.Shown in experimental result such as following table (table 8):
Table 8 polypeptide anti-acne skin rejuvenating facial mask and the contrast of existing Deacne pack
In order to save length, the present invention only enumerates section Example and experiment thereof, it practice, other technologies scheme of the present invention
Also close or identical beneficial effect can be reached.
List of references
[1] Zhong Xing, Guo Jianwei, Cheng Qiugui. win peptide application in facial film and latest developments [J]. household chemicals science,
2012,35 (11): 35-38.
[2]Papini A M.Cosmetics towards peptide-based cosmeceutics[J].Chimica
Oggi/Che-mistry Today,2010,28(6):3-4
[3] yellow Yadong. biologically active polypeptide application [c] in medical cosmetology. the 10th south east asia medical cosmetology is academic
Conference collection of thesis, 2006:14 17
[4] Wang Hongxiang. poplar is along equality. and medicinal plant extract combines the progress [J] of antibacterial peptide anti-acne effect. detergents and cosmetic
Product science, 2014,37, (10).
Claims (10)
1. a peptide species anti-acne skin rejuvenating facial mask, it is characterised in that weight percentage is calculated, including following components:
A peptide species anti-acne skin rejuvenating facial mask the most according to claim 1, it is characterised in that weight percentage is calculated,
Including following components:
A peptide species anti-acne skin rejuvenating facial mask the most according to claim 2, it is characterised in that weight percentage is calculated,
Including following components:
A peptide species anti-acne skin rejuvenating facial mask the most according to claim 1, it is characterised in that weight percentage is calculated,
Including following components:
A peptide species anti-acne skin rejuvenating facial mask the most according to claim 1, it is characterised in that weight percentage is calculated,
Including following components:
A peptide species anti-acne skin rejuvenating facial mask the most according to claim 1, it is characterised in that weight percentage is calculated,
Including following components:
7. according to the peptide species anti-acne skin rejuvenating facial mask described in claim 1-6 any one, it is characterised in that described six
The total weight percent of peptide-9, tetrapeptide-30, antibacterial peptide three kinds beauty treatment polypeptide is 10～15%.
8. according to the peptide species anti-acne skin rejuvenating facial mask described in claim 1-6 any one, it is characterised in that described six
The purity of peptide-9, tetrapeptide-30, antibacterial peptide three kinds beauty treatment polypeptide is at 95-99%.
9. the method preparing polypeptide anti-acne skin rejuvenating facial mask described in claim 1～8 any one claim, its feature
Being, the method comprises the following steps:
1) by former to water, Aloe vulgaris, butanediol, glycerol, hyaluronate sodium, squalane, tocopherol, Xanthan gum, stearic acid, Laurel
Spring polyethers-3, phenoxyethanol, methyl hydroxybenzoate, ethyl hydroxybenzoate add in retort, open stirring, are heated to 75～80 DEG C, stirring
It is uniformly dispersed；
2) cooling circulating water is opened, stirring cooling, when temperature is down to 40～45 DEG C, dairy yeast is added in retort, homogenizing 1
Minute, stirring and dissolving is complete；
3) continue stirring and be cooled to less than 37 DEG C, hexapeptide-9, tetrapeptide-30, antibacterial peptide are added in retort, homogenizing 2-3 minute,
Stirring and dissolving is complete, to obtain final product.
10. the polypeptide anti-acne skin rejuvenating facial mask described in claim 1 has antibacterial, anti-acne, dispels facial acne and life-time service can
Repair the effect of face pockmark.
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| CN103933553A (en) * | 2013-10-29 | 2014-07-23 | 广州柏纵生物科技有限公司 | Antibacterial peptide and cell growth factor containing nano particle used for treating acne |
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Application publication date: 20170104 |