CN106265171B - A kind of skin care compositions and preparation method thereof with antioxidant and anti-aging - Google Patents
A kind of skin care compositions and preparation method thereof with antioxidant and anti-aging Download PDFInfo
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- A61K8/676—Ascorbic acid, i.e. vitamin C
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Abstract
The invention discloses a kind of skin care compositions and preparation method thereof with antioxidant and anti-aging, the skin care compositions contains the auxiliary element of a effective amount of active constituent and surplus, and the active constituent includes oligopeptides -1, oligopeptides -6, dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate and bisabolol.Through the above technical solutions, disclosed by the invention have effects that antioxidant and anti-aging skin care compositions can effectively remove skin surface free radical, moisture content of skin is kept, improvement skin is obscure, desalinates facial wrinkles, wrinkle is delayed to be formed.
Description
Technical field
This disclosure relates to skin care implement field, and in particular, to a kind of to have effects that the skin care of antioxidant and anti-aging
Composition and preparation method thereof.
Background technique
Skin is the natural barrier of human body, has the protective effect of various aspects to body.And body is in oxidative metabolism mistake
Cheng Zhonghui is constantly generated free radicals；In addition the factors such as environmental pollution, radiation, bad life habits influence, and can accelerate free radical
Constantly generate.The generation and accumulation of free radical will lead to collagen and elastin laminin in skin and decompose, cutis laxa, and then go out
Existing wrinkle；Lipoid brown pigment can be formed with unsaturated fatty acid under oxide skin simultaneously, skin is caused sunburn, chloasma, old occur
A series of problems, such as year spot.
In the market existing many anti-ageing anti-wrinkle cosmetics mostly with supplement in skin collagen and elastin laminin content or
Free radical production is reduced using single antioxidant to achieve the purpose that anti-aging, but substance contained therein is mostly macromolecular,
And the molecule more than 40000D or more is difficult to be directed through epidermis and is absorbed by the skin, and leads to that anti-oxidant, anti-aging effects are undesirable.
Mainly by cuticula, three kinds of approach of pilosebaceous follicle and sweat duct mouth are carried out for the infiltration and absorption of skin.Cuticula is in skin
Skin surface forms a half penetrating film complete and that physical property is stable, is the most important approach that skin absorbs.Pass through compatibility
Excellent grease cooperation small-molecule active substance and a variety of antioxidant combinations, developing a kind of both can effectively remove freedom
Base, and intracellular promotion collagen and the regenerated anti-aging product of elastin laminin can be entered through cell membrane, it could be really high
Effect achievees the purpose that anti-aging.
Summary of the invention
Purpose of this disclosure is to provide a kind of composition, the composition can significantly improve a variety of skin problems.
To achieve the goals above, the disclosure provide it is a kind of have effects that the skin care compositions of antioxidant and anti-aging, it is described
Skin care compositions contains the auxiliary element of a effective amount of active constituent and surplus, the active constituent include oligopeptides -1, oligopeptides -6,
Dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate, tocopherol second
Acid esters and bisabolol.
The disclosure additionally provides the preparation method of the skin care compositions, which includes the following steps: (1) by two
Methyl methoxy base benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate, tocopheryl acetate
Ester, sunflower seed oil unsaponifiable matter, bisabolol, retinol, ring five dimethyl silicone polymer, dimethyl silicone polymer, poly- two
The coconut oil ethylhexyl of methylsiloxane alcohol, caprylic/capric triglyceride and surplus is added oily phase pot, is heated to 90-95
DEG C, temperature sterilizing is kept, uniform liquid is stirred into, then be down to 75-85 DEG C, obtains oil phase material；(2) oil is added in emulsion pot
Phase materials, 75-85 DEG C of emulsifying homogeneous are cooled to 42 DEG C, and oligopeptides -1, oligopeptides -6 and tocopherol is added, stirs evenly, is down to room
Temperature.
Through the above technical solutions, the skin care compositions of the disclosure effectively can delay wrinkle to be formed, desalinate countenance
Line removes skin surface free radical, prevents color spot and hyperplastic scar generates, thus slowing down skin aging.
Other feature and advantage of the disclosure will the following detailed description will be given in the detailed implementation section.
Specific embodiment
The specific embodiment of the disclosure is described in detail below.It should be understood that described herein specific
Embodiment is only used for describing and explaining the disclosure, is not limited to the disclosure.
Disclosure first aspect: providing a kind of has effects that the skin care compositions of antioxidant and anti-aging, the skincare composition
Object contains the auxiliary element of a effective amount of active constituent and surplus, and the active constituent may include oligopeptides -1, oligopeptides -6, diformazan
Ylmethoxy benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate
And bisabolol.
Above-mentioned skin care compositions provided by the invention has bioactive ingredients and without side-effects, and no dependence does not jeopardize
Human health and have the effects that anti-ageing, crease-resistant, light spot, whitening, moisturizing, desalination red capillary.It is easier to permeate based on dissociation substance
Enter the Biological Principles of skin basement membrane, integral formula seeps small molecule oligopeptides through corneocyte film by cutin-softening layer
It penetrates into corneocyte, then enters skin corium through epidermis, improve skin oxidation resistance, keep skin moisture, improve
The colour of skin is obscure, delays senescence.
According to the disclosure in a first aspect, in order to further enhance the skin care compositions using effect, the activity
Ingredient can also contain retinol and/or tocopherol.
It is described auxiliary according to the disclosure in a first aspect, in order to improve the stability of the skin care compositions and use feeling
Co-ingredients may include ring five dimethyl silicone polymer, dimethyl silicone polymer, dimethiconol, sunflower seed oil not
At least one of saponified, caprylic/capric triglyceride and coconut oil ethylhexyl.
According to the first aspect of the disclosure, it is preferable that on the basis of the total weight of the composition and with weight percent
Meter, the effective component includes the dimethyl methoxy of the oligopeptides -1 of 0.5-2.0%, the oligopeptides -6 of 0.5-2.0%, 0.1-0.5%
Base benzodihydropyran alcohol, the wing seed seed oil of Moringa oleigera of 1.0-5.0%, the saualane of 1.0-5.0%, 2.0-3.0% Vitamin C
Sour four different palmitates, the tocopherol acetate of 0.3-1.0%, the bisabolol of 0.1-0.5%, 0.5-2.0% retinol
With the tocopherol of 0.1-0.5%.The concentration of effective component in the above range when have better using effect.
Preferably, on the basis of the total weight of the composition and by weight percentage, the effective component can wrap
Include 1.5% oligopeptides -1,1.5% oligopeptides -6,0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4% wing seed Moringa
Seed oil, 3% saualane, 3% Ascorbyl Tetraisopalmitate, 0.8% tocopherol acetate, 0.2% opopanax
Alcohol, 1.5% retinol and 0.4% tocopherol.The composition can also containing 40% ring five dimethyl silicone polymer,
20% dimethyl silicone polymer, 15% dimethiconol, 7% caprylic/capric triglyceride, 1.4% coconut palm
Oleic acid ethylhexyl and 0.3% sunflower seed oil unsaponifiable matter.
The second aspect of the disclosure: a kind of preparation side with the skin care compositions of antioxidant and anti-aging is provided
Method, the skin care compositions contain the dimethyl methoxy of the oligopeptides -1 of 0.5-2.0%, the oligopeptides -6 of 0.5-2.0%, 0.1-0.5%
Base benzodihydropyran alcohol, the wing seed seed oil of Moringa oleigera of 1.0-5.0%, the saualane of 1.0-5.0%, 2.0-3.0% Vitamin C
Sour four different palmitates, the tocopherol acetate of 0.3-1.0%, 0.2-0.5% sunflower seed oil unsaponifiable matter, 0.1-
0.5% bisabolol, the retinol of 0.5-2.0%, the tocopherol of 0.1-0.5%, 30-60% five polydimethylsiloxanes of ring
Alkane, the dimethyl silicone polymer of 10-25%, the dimethiconol of 10-20%, 7-15% caprylic/capric triglyceride
With the coconut oil ethylhexyl of surplus, wherein the preparation method includes the following steps:
(1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, the different palm of ascorbic acid four
Acid esters, tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol, ring five dimethyl silicone polymer, poly- two
Methylsiloxane, dimethiconol, caprylic/capric triglyceride and surplus coconut oil ethylhexyl, oily phase is added
Pot is heated to 90-95 DEG C, keeps temperature sterilizing, stirs into uniform liquid, then be down to 75-85 DEG C, obtain oil phase material；
(2) oil phase material is added in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, and oligopeptides -1, oligopeptides-is added
6 and tocopherol, it stirs evenly, is down to room temperature.
According to the second aspect of the disclosure, it is preferable that the skin care compositions contains 1.5% oligopeptides -1,1.5% widow
The dimethyl methyl epoxide benzodihydropyran alcohol of peptide -6,0.4%, 4% wing seed seed oil of Moringa oleigera, 3% saualane, 3% it is anti-
The different palmitate of bad hematic acid four, 0.8% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter, 0.2% red do not have
Medicine alcohol, 1.5% retinol, 0.4% tocopherol, 40% ring five dimethyl silicone polymer, 20% polydimethylsiloxanes
Alkane, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethylhexyl.
The disclosure is further elaborated by the following examples, and is not so limited the disclosure.
Embodiment 1
On the basis of the total weight of composition and by weight percentage, the skin care compositions contain 1.5% oligopeptides -1,
1.5% oligopeptides -6,0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4% wing seed seed oil of Moringa oleigera, 3% spiny dogfish
Alkane, 3% Ascorbyl Tetraisopalmitate, 0.8% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter,
0.2% bisabolol, 1.5% retinol, 0.4% tocopherol, 40% ring five dimethyl silicone polymer, 20% it is poly-
Dimethyl siloxane, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethyl hexyl
Ester.
The preparation method of the composition include: (1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera,
Saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol,
Ring five dimethyl silicone polymer, dimethyl silicone polymer, dimethiconol, caprylic/capric triglyceride and surplus
Coconut oil ethylhexyl is added oily phase pot, is heated to 90-95 DEG C, keeps temperature sterilizing, stirs into uniform liquid, then be down to 75-
85 DEG C, obtain oil phase material；(2) oil phase material is added in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, is added few
Peptide -1, oligopeptides -6 and tocopherol, stir evenly, and are down to room temperature, obtain skin care compositions as described above.
Embodiment 2
On the basis of the total weight of composition and by weight percentage, the skin care compositions contain 1.3% oligopeptides -1,
0.8% oligopeptides -6,0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4.9% wing seed seed oil of Moringa oleigera, 3% spiny dogfish
Alkane, 3% Ascorbyl Tetraisopalmitate, 0.8% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter,
0.2% bisabolol, 1.5% retinol, 0.4% tocopherol, 40% ring five dimethyl silicone polymer, 20% it is poly-
Dimethyl siloxane, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethyl hexyl
Ester.
Skin care compositions described in the present embodiment is prepared according to the identical preparation method in embodiment 1.
Embodiment 3
On the basis of the total weight of composition and by weight percentage, the skin care compositions contain 1.8% oligopeptides -1,
1.8% oligopeptides -6,0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4% wing seed seed oil of Moringa oleigera, 3% spiny dogfish
Alkane, 3% Ascorbyl Tetraisopalmitate, 0.4% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter,
0.2% bisabolol, 1.5% retinol, 0.2% tocopherol, 40% ring five dimethyl silicone polymer, 20% it is poly-
Dimethyl siloxane, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethyl
Own ester.
Skin care compositions described in the present embodiment is prepared according to the identical preparation method in embodiment 1.
Comparative example 1
On the basis of the total weight of composition and by weight percentage, which contains 1.5% Vitamin C
Acid, 3% oligopeptides -6,0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4% wing seed seed oil of Moringa oleigera, 3% spiny dogfish
Alkane, 1.5% Ascorbyl Tetraisopalmitate, 0.8% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter,
0.2% bisabolol, 1.5% retinol, 0.4% tocopherol, 40% ring five dimethyl silicone polymer, 20% it is poly-
Dimethyl siloxane, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethyl hexyl
Ester.
The preparation method of the composition include: (1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera,
Saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol,
Ring five dimethyl silicone polymer, dimethyl silicone polymer, dimethiconol, caprylic/capric triglyceride and surplus
Coconut oil ethylhexyl is added oily phase pot, is heated to 90-95 DEG C, keeps temperature sterilizing, stirs into uniform liquid, then be down to 75-
85 DEG C, obtain oil phase material；(2) oil phase material is added in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, is added anti-
Bad hematic acid, tocopherol and oligopeptides -6, stir evenly, are down to room temperature, obtain skin care compositions as described above.
Comparative example 2
On the basis of the total weight of composition and by weight percentage, the skin care compositions contain 3% oligopeptides -1,
0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4% wing seed seed oil of Moringa oleigera, 3% saualane, 3% ascorbic acid
Four different palmitates, 0.8% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter, 0.2% bisabolol,
1.5% retinol, 0.4% tocopherol, 40% ring five dimethyl silicone polymer, 20% dimethyl silicone polymer,
15% dimethiconol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethylhexyl.
The preparation method of the composition include: (1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera,
Saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol,
Ring five dimethyl silicone polymer, dimethyl silicone polymer, dimethiconol, caprylic/capric triglyceride and surplus
Coconut oil ethylhexyl is added oily phase pot, is heated to 90-95 DEG C, keeps temperature sterilizing, stirs into uniform liquid, then be down to 75-
85 DEG C, obtain oil phase material；(2) oil phase material is added in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, is added few
Peptide -1 and tocopherol, stir evenly, and are down to room temperature, obtain skin care compositions as described above.
Comparative example 3
On the basis of the total weight of composition and by weight percentage, which contains 0.8% dimethyl
Methoxyl group benzodihydropyran alcohol, 4.0% wing seed seed oil of Moringa oleigera, 3.0% saualane, 3.8% the different palm fibre of ascorbic acid four
Glycerin monostearate, 1.6% tocopherol acetate, 0.3% sunflower seed oil unsaponifiable matter, 0.2% bisabolol, 2% view
Flavol, 0.9% tocopherol, 40% ring five dimethyl silicone polymer, 20% dimethyl silicone polymer, 15% poly dimethyl
Siloxanes alcohol, 7% caprylic/capric triglyceride and 1.4% coconut oil ethylhexyl.
The preparation method of the composition include: (1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera,
Saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol,
Ring five dimethyl silicone polymer, dimethyl silicone polymer, dimethiconol, caprylic/capric triglyceride and surplus
Coconut oil ethylhexyl is added oily phase pot, is heated to 90-95 DEG C, keeps temperature sterilizing, stirs into uniform liquid, then be down to 75-
85 DEG C, obtain oil phase material；(2) oil phase material is added in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, and life is added
Phenol is educated, is stirred evenly, room temperature is down to, obtains skin care compositions as described above.
Testing example 1
This testing example is used to detect the free radical for the skin care compositions that embodiment 1-3 and comparative example 1-3 are prepared
Scavenging activity.
It is separately added into the DPPH solution that 4ml concentration is 0.0178mM in 6 10ml colorimetric cylinders, Example 1-3, compares
Each 0.1g of skin care compositions in example 1-3 is separately added into 6 colorimetric cylinders, then is separately added into dehydrated alcohol to 10ml, after mixing
Light absorption value (A) of the mixed solution at 517nm wavelength is surveyed using 1cm cuvette immediately；Room temperature is kept in dark place, and measures one per minute
Secondary light absorption value, test result are shown in Table 1:
Table 1 short time radicals scavenging force and energy measurement result
Conclusion: from table 1, according to analysis of experimental results, the effect that different embodiments remove free radical in a short time is deposited
In notable difference, wherein embodiment 1 is smearing the clear superiority for showing removing free radical after five minutes completely, excellent after ten minutes
Gesture gradually widens, hence it is evident that is better than embodiment 2-3 and comparative example 1-3.So embodiment 1 removes free radical after smearing in the short time
Ability it is stronger, there is better antioxidant effect, and oxidation resistance is lasting.
Testing example 2
This testing example is used to detect the anti-wrinkle effect of skin care compositions of the present invention.Select health, brow furrows
Grade is 3 grades, is ready cooperation research, women 60 that the age is 40-45 one full year of life, is randomly divided into test group 1-3, comparative group 1-3,
Every group subject 10.Exclusion criteria: the active skin disease of test zone (forehead), mole are tatooed, high susceptibility skin, clothes
The women treated with immunosuppressive drug.
Test group: after morning and evening face cleaning, the skin care compositions 0.35g in above-described embodiment 1-3 is uniformly applied to face respectively
Portion's skin, the course for the treatment of are 5 weeks；Comparative group: respectively that the skin care compositions 0.35g in above-mentioned comparative example 1-3 is uniform after morning and evening face cleaning
It is applied to skin of face, the course for the treatment of is 5 weeks.
Test method: selection forehead region is recipient site, measures wrinkle duplicate rough surface using talysurf
Degree.The wrinkle grade scale used is 0 grade: the depth of wrinkle is less than 49 μm；1 grade: 2 or 3 shallow wrinkles, wrinkle depth range
It is 50-100 μm, length < 1.5cm；2 grades: 4 to 6 shallow wrinkles, wrinkle depth range are 0.2-0.5mm, length < 2cm；3
Grade:, compared with deep wrinkle, wrinkle depth range is 0.6-1mm for several, and length reaches 3cm, while with shallow wrinkle.Curative effect judgment criteria:
After one course for the treatment of, the wrinkle grade of 60 subjects is measured, calculates the integrated level of each group wrinkle depth after treatment, and use system
Whether meter method relatively has significant difference before and after treatment.Test result is shown in Table 2.
The crease-resistant evaluation and test effect of table 2
Conclusion: from the point of view of crease-resistant evaluation result, the anti-wrinkle treatment effect of embodiment 1 and embodiment 3 is better than embodiment 2；It is real
Example is applied compared with comparative example, embodiment is generally better than comparative example.Therefore, the formula from the point of view of short-term anti-wrinkle effect, in embodiment 1
It has a clear superiority.
Testing example 3
This testing example is used to detect the skin care compositions replenishing water and preserving moisture effect of 1-3 of the embodiment of the present invention, comparative example 1-3
Fruit.
Experimental method: after subject carries out careful face cleaning, 3 × 3cm is marked in the left cheek side of subject2The pros of size
Shape Experimental Area uses moisture of skin tester (being purchased from Corneometer company, model CM825) as blank district
Test detects the moisture content of each Test sites, using right cheek as the test zone of embodiment 1-3 or comparative example 1-3, often
A test zone smears the skin care compositions of 0.35g, then in constant temperature and humidity (humidity: 50% ± 2%；21 DEG C ± 0.5 of temperature
DEG C) in the environment of sit quietly, respectively test smear half an hour after, 1 hour, 1.5 hours, 2 hours, each Test sites after 3 hours
Moisture content, calculate the average value tested every time, subject be calculated when different by formula (A) again after recording data
Between spaced points average hydration rate, the hydration rate calculated result of embodiment 1-3 and comparative example 1-3 is shown in Table 3:
3 moisturizing testing result of table
| After processing | 0 hour | 0.5 hour | 1 hour | 1.5 hour | 2 hours | 3 hours |
| Embodiment 1 | 1.32 | 56.82 | 88.46 | 86.46 | 87.55 | 90.69 |
| Embodiment 2 | 1.34 | 50.49 | 80.51 | 81.92 | 83.49 | 83.58 |
| Embodiment 3 | 1.04 | 48.47 | 77.54 | 73.38 | 75.59 | 77.22 |
| Comparative example 1 | 1.67 | 42.84 | 67.87 | 68.75 | 66.72 | 68.29 |
| Comparative example 2 | 1.56 | 38.31 | 60.33 | 62.29 | 61.66 | 61.14 |
| Comparative example 3 | 1.85 | 26.03 | 52.31 | 50.69 | 52.13 | 50.35 |
Conclusion: moisturizing testing result shows that the moistening effect of embodiment 1 and embodiment 2 is similar, hence it is evident that is better than embodiment
3, embodiment 1-3 is substantially better than comparative example 1-3.
Testing example 4
This testing example is for detecting the present composition to the improvement therapeutic effect of dermatoglyph.
Object Selection and grouping: forming test population by 70 30-55 years old aging face women, with 10 people for one group,
Subject smears the skin care compositions of embodiment 1-3, comparative example 1-3 in facial area respectively after receiving microneedle theraphy, records it
The variation of pretherapy and post-treatment dermatoglyph.Blank control group be microneedle theraphy after, do not smear any skin care compositions in recipient site.
Exclusion criteria: (1) pregnancy and breast feeding women；(2) intentionally, liver, renal damage and other whole bodies serious disease person；
(3) there is facial acute skin patient；(4) to the therapeutic value person of having too high expectations.
Method: lidocaine emulsifiable paste is smeared in treatment region after face cleaning, surface coating 50min wipes lidocaine after anesthesia
Emulsifiable paste sterilizes liquid disinfectant using Swashes, and patient wears sterile glove, inspires confidence in 0.25- using sterile space according to patient skin situation
0.5mm needle roller is uniformly rolled facial, and the skin care compositions dipped in embodiment 1-3 and comparative example 1-3 respectively with cotton swab is uniform
Be applied to each group subject face, do not get wet in 48h, after 48h can normal face cleaning, smear skin care item.Patient is daily with corresponding shield
Skin composition coating surface 3 times, pays attention to sun-proof.Treatment interval 15 days, 5 treatments were completed in total.Blank control group is above-mentioned except not smearing
Skincare composition beyond the region of objective existence, remaining is the same as test group and comparative group.
Efficacy determination: technical staff is applied using MicroSkinII Multi-functional skin mirror image analysis system measurement recipient site
Dermatoglyph degree before smearing skin care compositions.Subject is after being used continuously cosmetics one week, two weeks, three weeks and four weeks, weekly
Same time subject cleans position is smeared, and is surveyed by tester using MicroSkinII Multi-functional skin mirror image analysis system
Determine spreader portion bit value.The numerical value that statistics subject position measures every time, analyzing skin texture changing rule.Skin line
Formula (1) is shown in the calculating of reduced rate in reason situation of change.
Specific experiment the results are shown in Table 4:
Reduced rate=(test group/comparative group data TnInitial value T0)/initial value T0Formula (1)
4 dermatoglyph of table improves result
Conclusion: from table 4, it can be seen that within test period, after recipient site uses skin care compositions, test group and compare
The variation of the skin roughness of group is substantially on a declining curve, and always below blank group, skin care compositions phase provided by the invention
More obviously improve than in other compositions or other composition proportions there is the skin roughness of recipient site.
In conclusion skin care item of the present invention have obvious holding skin moisture, wrinkle is reduced, the work of cutaneous roughness is reduced
With with senile-resistant efficacy outstanding.
The preferred embodiment of the disclosure is described in detail above, still, during the disclosure is not limited to the above embodiment
Detail a variety of simple variants can be carried out to the technical solution of the disclosure in the range of the technology design of the disclosure, this
A little simple variants belong to the protection scope of the disclosure.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, it can be combined in any appropriate way.In order to avoid unnecessary repetition, the disclosure to it is various can
No further explanation will be given for the combination of energy.
In addition, any combination can also be carried out between a variety of different embodiments of the disclosure, as long as it is without prejudice to originally
Disclosed thought equally should be considered as disclosure disclosure of that.
Claims (7)
1. a kind of have effects that the skin care compositions of antioxidant and anti-aging, the skin care compositions contain a effective amount of active constituent
With the auxiliary element of surplus, which is characterized in that the active constituent is by oligopeptides -1, oligopeptides -6, dimethyl methyl oxygroup benzo dihydro
Pyrans alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate, tocopherol acetate, bisabolol, retinol
It is formed with tocopherol；On the basis of the total weight of the composition and by weight percentage, a effective amount of active constituent
By the oligopeptides -1 of 0.5-2.0%, the oligopeptides -6 of 0.5-2.0%, 0.1-0.5% dimethyl methyl epoxide benzodihydropyran alcohol,
The wing seed seed oil of Moringa oleigera of 1.0-5.0%, the saualane of 1.0-5.0%, 2.0-3.0% Ascorbyl Tetraisopalmitate,
The tocopherol acetate of 0.3-1.0%, the bisabolol of 0.1-0.5%, the retinol of 0.5-2% and the fertility of 0.1-0.5%
Phenol composition.
2. composition according to claim 1, wherein the auxiliary element includes ring five dimethyl silicone polymer, poly- two
Methylsiloxane, dimethiconol, caprylic/capric triglyceride, sunflower seed oil unsaponifiable matter and coconut oil ethyl
At least one of own ester.
3. composition according to claim 2, wherein on the basis of the total weight of the composition and with weight percent
Meter, the composition also ring five dimethyl silicone polymer containing 30-60%, the dimethyl silicone polymer of 10-25%, 10-
20% dimethiconol, 7-15% caprylic/capric triglyceride, 0.2-0.5% sunflower seed oil unsaponifiable matter
With the coconut oil ethylhexyl of surplus.
4. composition according to claim 3, wherein on the basis of the total weight of the composition and with weight percent
Meter, the effective component by 1.5% oligopeptides -1,1.5% oligopeptides -6,0.4% dimethyl methyl oxygroup benzodihydropyran
Alcohol, 4.0% wing seed seed oil of Moringa oleigera, 3.0% saualane, 3.0% Ascorbyl Tetraisopalmitate, 0.8% fertility
Phenol acetic acid esters, 0.2% bisabolol, 1.5% retinol and 0.4% tocopherol composition.
5. composition according to claim 4, wherein by weight percentage, the composition also containing 40% ring
Five dimethyl silicone polymers, 20% dimethyl silicone polymer, 15% dimethiconol, 0.3% sunflower seed
Oily unsaponifiable matter, 7.0% caprylic/capric triglyceride and 1.4% coconut oil ethylhexyl.
6. a kind of preparation method with the skin care compositions of antioxidant and anti-aging, by weight percentage, the skin care group
Close object by the oligopeptides -1 of 0.5-2.0%, the oligopeptides -6 of 0.5-2.0%, 0.1-0.5% dimethyl methyl oxygroup benzodihydropyran
Alcohol, the wing seed seed oil of Moringa oleigera of 1.0-5.0%, the saualane of 1.0-5.0%, 2.0-3.0% Ascorbyl Tetraisopalmitate,
The tocopherol acetate of 0.3-1.0%, the sunflower seed oil unsaponifiable matter of 0.2-0.5%, 0.1-0.5% bisabolol,
The retinol and the tocopherol of 0.1-0.5% of 0.5-2.0%, the ring five dimethyl silicone polymer of 30-60%, 10-25% it is poly-
Dimethyl siloxane, the dimethiconol of 10-20%, 7-15% caprylic/capric triglyceride and surplus coconut oil
Ethylhexyl composition；Wherein, which includes the following steps:
(1) by dimethyl methyl epoxide benzodihydropyran alcohol, wing seed seed oil of Moringa oleigera, saualane, Ascorbyl Tetraisopalmitate,
Tocopherol acetate, sunflower seed oil unsaponifiable matter, bisabolol, retinol, ring five dimethyl silicone polymer, poly dimethyl silicon
Oxygen alkane, dimethiconol, caprylic/capric triglyceride and surplus coconut oil ethylhexyl, oily phase pot, heating is added
To 90-95 DEG C, temperature sterilizing is kept, uniform liquid is stirred into, then be down to 75-85 DEG C, obtains oil phase material；
(2) be added oil phase material in emulsion pot, 75-85 DEG C of emulsifying homogeneous is cooled to 42 DEG C, be added oligopeptides -1, oligopeptides -6 and
Tocopherol stirs evenly, and is down to room temperature.
7. preparation method according to claim 6, wherein by weight percentage, the skin care compositions by 1.5% widow
The oligopeptides -6 of peptide -1,1.5%, 0.4% dimethyl methyl epoxide benzodihydropyran alcohol, 4.0% wing seed seed oil of Moringa oleigera,
3.0% saualane, 3.0% Ascorbyl Tetraisopalmitate, 0.8% tocopherol acetate, 0.3% sunflower seed
Oily unsaponifiable matter, 0.2% bisabolol, 1.5% retinol, 0.4% tocopherol, 40% five polydimethylsiloxanes of ring
Alkane, 20% dimethyl silicone polymer, 15% dimethiconol, 7% caprylic/capric triglyceride and 1.4%
Coconut oil ethylhexyl composition.
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| CN111616991A (en) * | 2020-07-22 | 2020-09-04 | 杭州百芮生物科技有限公司 | Moisturizing, skin-brightening and spot-fading composition, preparation method and application |
| CN112618457A (en) * | 2020-12-31 | 2021-04-09 | 泉后(广州)生物科技研究院有限公司 | Chloasma-removing composition and preparation method and application thereof |
| CN113576940A (en) * | 2021-08-10 | 2021-11-02 | 杭州三玄健康科技有限公司 | Active peptide anti-inflammatory repair composition, essence thereof and preparation method |
| CN114652630B (en) * | 2022-04-02 | 2023-03-24 | 浙江宜格企业管理集团有限公司 | Antioxidant composition with synergistic effect |
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