CN106243162B - The preparation method of sucrose complex - Google Patents
The preparation method of sucrose complex Download PDFInfo
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- CN106243162B CN106243162B CN201610613959.1A CN201610613959A CN106243162B CN 106243162 B CN106243162 B CN 106243162B CN 201610613959 A CN201610613959 A CN 201610613959A CN 106243162 B CN106243162 B CN 106243162B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Abstract
The invention discloses a kind of preparation methods of sucrose complex, it is by sucrose and molysite complex reaction, obtain iron sucrose solution, then it filters after cooling, filter residue and filtrate are obtained, filtrate is added ethanol water and is settled out complex compound, and precipitating centrifugation is filtered, vacuum drying drying obtains purer sucrose complexing iron product；The iron concentration for detecting filter residue is 1:4 according to the molar ratio of sucrose and iron ion, continuously adds sucrose and ferrous salt, will be centrifuged filtered waste water back to the mother liquor in reaction kettle as dissolving saccharose, circular response continues generation iron sucrose.The present invention prepares the process of iron sucrose, not waste of resource, reduces production cost, improves production efficiency.Iron sucrose is obtained with safe and efficient, high performance-price ratio advantage, can be applied to be suitble to the production comprehensive animal feed of nutrition.
Description
Technical field
The present invention relates to a kind of complex compounds, especially sucrose complex and preparation method thereof, and disclose its purposes.
Background technique
The nutritive physiology function of iron: 1, the component as carrier and enzyme: iron takes part in the group of hemoglobin and myoglobins
At being responsible for the important function of oxygen and carbon dioxide in carrier.In addition, iron directly participates in cytochrome oxidase, peroxidating
The composition of object enzyme and xanthine oxidase etc..Divalent or ferric ion are to activate the various enzymes of carbohydrate metabolism not again
The activation factor that can lack；2, participate in protein synthesis and energetic supersession: the content of iron directly affects the content of phosphorus in animal body,
The synthesis of DNA when iron deficiency in liver cell can be suppressed because lacking phosphorus, and the mitochondria and microsome in histocyte are abnormal.This
Outside, iron participates in the energy metabolism in zooblast as the component of cytochromes.Romslo thinks the release of energy i (in vivo)
The quantity of mitochondria aggregation iron is depended on, and the two is directly proportional；3, physiology defence and immunity function: the newborn iron in leucocyte or milk
The iron ion to dissociate in enteron aisle can be combined into compound by albumen, in order to the utilization of Bacillus acidi lactici, while inhibit large intestine
The effect of bacillus can prevent the diarrhea of new born animal especially piglet well.Asiderosis and excess: 1, anaemia: this is
The most significant symptom of object iron deficiency.Iron can influence the synthesis of vivo protein, when iron deficiency, in liver cell and other histocytes
Mitochondria and microsome are abnormal, and the decline of cromoci content, protein synthesis and energy utilization are obstructed, and anaemia, body occurs in animal
Decline again.The explanation of another mechanism of action is: after iron deficiency, the DNA synthesis of lymphocyte is disturbed, and is lost to specific antigen
Sensibility, the stress ability decline of body fight infections, susceptible, the destruction of red blood cell accelerates after infection, causes animal poor
Blood；2, lesion occurs in oxidation-reduction process disorder: research has shown that, has more than half enzyme to contain iron in tricarboxylic acid cycle, or
Competence exertion biochemical action in the presence of iron.The activity that iron deficiency will lead to these enzymes is severely impacted, to influence internal oxygen
Transport and storage.In addition, ferrous sulfide compound is proved all to play key in many redox reactions of biosystem
The effect of property.Iron is insufficient, and the oxidation-reduction process of respiratory chain and peroxide can get muddled, and influences the normal generation of body
It thanks；3, immune function reduces: immune function reduces, and increases the sensibility of bacterium and parasitic infection, so that weight and body are long
Growth and development be adversely affected.Such as the diarrhea of piglet and the high death rate；4, iron poisoning: in pig perfect compound feed
Normal addition chalybeate amount is generally below 0.014%, and the normal additive amount of broiler chicken is 0.008%, laying hen 0.005%, if addition
20 times of the amount of being above standard of amount or more just will appear chronic iron poisoning phenomenon.The dosis tolerata of iron is generally large.Iron in pig feeding daily ration
Dosis tolerata 3000mg, ox and fowl are 1000mg.But addition is excessive, easily causes poisoning.10 age in days Piglet by Oral ferrous sulfate of 3-
Toxic dose are as follows: 600mg weight, feed after 1-3h may occur in which poisoning symptom.It is obtained in addition, intravenous injection molysite is bigger than oral toxicity
It is more.One injection high dose iron preparation can also cause piglet to be poisoned after 3-5h.Hu Xingui (1999) report, gives piggy injection iron
Agent 200ml, i.e. benefit iron reach 450-750mg, occur as soon as poisoning symptom.Show as flush, dull mind, astasia,
It is short of breath, hypothermia is drowsiness, then goes into a coma, dead when serious.Application of the iron additive on animal productiong: it raises at present
Iron additive used in material experienced three developing stage, first generation product, that is, inorganic iron: ferrous sulfate, ferrous carbonate, three
Iron oxide, iron chloride, frerrous chloride etc.；Second generation product, that is, organic salt iron: ferric lactate, ferrous citrate, prolongs recklessly ferrodextranum
Rope acid iron etc.；Third is on behalf of protein sources or amino acid chelated iron: ferrous methionine chelate, threonine chelated iron etc..Inorganic iron: sulfuric acid
Ferrous salt is that good inorganic source of iron, especially ferrous sulfate heptahydrate salt are most widely used in current feed industry.Japanology
Person (1993) studies have shown that in the food stuff for chicken laying of laying period mix 100mg FeSO4 powder feed, the iron deficiency of hen can be prevented
Property anaemia, and then improve 25% or more laying rate.Since ferrous sulfate dissolubility is good and can be used as effective heme moiety, institute
To be often used in mending iron to piglet, generally, for prevention piglet anaemia or bacterial infection toxin, it is ensured that normal growth, 2-3 age in days is just
Iron should be mended.The mode of supplement chalybeate, which has, mends iron directly to piglet and mends two kinds of iron indirectly by parent, such as uses ferrous sulfate
200mg iron feeds sow, and the content of iron in pig manure can be improved, piglet is made to eat sow excrement 50-80g daily, can get pre- enough
The iron of anti-anaemia.
Organic Iron: the organic salts such as ferrodextranum, ferrous citrate, ferric lactate dissolubility is good, it is easy absorb, biological value compared with
High, stability is also compared with inorganic salts height.Organic salt iron mainly plays nutrition and immune in Production of Livestock and Poultry.(1) in terms of nutrition:
It is obviously rapid to mend iron effect for Organic Iron, organic cobalt and vitamin optimum organization.It can be improved the reproductive performance of sow, improve young
Pig survival rate, birth weight.Can improve egg fowl lay eggs quality, reduce shell-breaking rate, deepen yolk color, reduce stress.(2) exempt from
In terms of epidemic disease: effectivelying prevent piglet anaemia, inhibit cub diarrhea, piglet white scour.Amino acid chelated iron: amino acid chelated iron is a kind of
A kind of complex compound for cyclic structure that ligand (amino acid) same metal ion species (microelement) are formed.Common chelate ring
There are five-membered ring and hexatomic ring, wherein a-amino acid chelated iron is five-membered ring, and beta-amino acids chelated iron is hexatomic ring.Microelement quilt
After chelating amino acids, the moderate chelate of stability constant is generated, these chelates utilize Amino Acid Absorption channel in small intestine, keep away
Exempt from and the competition of other mineral elements by the operating of mineral element Ions Absorption channel and antagonism.In addition the biochemistry of chelate
Property is more stable, effectively resists other nutrients in daily ration and adverse effect occurs therewith.Chelate solubility property in body is good,
It easily absorbs, utilization rate height.In addition, amino acid chelated iron also has certain sterilization and immune function.It is believed that Chelating state is micro-
Secondary element plays specific function in specific organization, target organ or functional site.
Currently, adding iron in internal feed still based on inorganic iron (ferrous sulfate).It is at low cost, and processing technology is simple,
It is from a wealth of sources, and the growth to livestock and poultry, breeding, production, immune etc. have preferable facilitation.But the iron ion in inorganic iron
Easily with other mineral ion antagonisms, compete, utilization rate caused to decline, food consumption increases, and is not able to satisfy modern production increasingly
Demand.Antagonism and race problem between mineral element ion has been effectively relieved in the appearance of amino acid chelated iron.
However, with amino-acid complex (chelating) microelement of the synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost is increasingly prominent.
Therefore, in order to reduce use cost, the present inventor makes full use of the locality that Guangxi cane planting is wide, sugar industry is flourishing
Affluent resources, by the complex reaction of sucrose and manganese salt, obtain sucrose manganese, greatly reduce enterprise using sucrose as primary raw material
Production cost, improve the competitiveness of enterprise.
It yet there are no disclosure and reported application of the single iron sucrose in terms of feed addictive.
Summary of the invention
It is a kind of with safe and efficient, high sexual valence the purpose of the present invention is In view of the above shortcomings of the prior art, providing
The advantage of ratio will play the iron sucrose of positive guidance and impetus to the development of organic trace element industry even animal husbandry
Complex compound.
The present invention is implemented as follows:
The preparation method of sucrose complex of the present invention includes the following steps:
Step 1: sucrose and water are uniformly mixed according to the ratio of weight fraction 25-32:40-50, according to sucrose and ferrous iron
The weight fraction of salt is that ferrous salt is added in 25-32:20-30, and sodium hydrate aqueous solution adjusting pH 11-12 is added and obtains reaction solution；
Step 2: reaction solution obtained by step 1 is kept the temperature 1-2 hours under the conditions of 65-75 DEG C of temperature, being stirred continuously, it is cooling
It is separated by filtration, obtains filter residue and filtrate；
It is 1: 2 addition 75% by the weight ratio of filtrate and 75% ethanol water Step 3: taking filtrate obtained by step 2
Ethanol water room temperature precipitates 1.5-3 hours, and sediment is filtered by centrifugation, obtained waste water and sediment, and sediment is through true
Sky is dry, and detection obtains iron sucrose product；
Step 4: taking filter residue in step 2 and detecting iron concentration therein, according to the molar ratio of sucrose and iron ion
Sucrose and molysite are added into filter residue for 1:4, step 3 is taken to be centrifuged the filter that sucrose and ferrous salt is added in filtered waste water dissolution
Slag, the pH 11-12 that adding sodium hydroxide aqueous solution adjusts solution obtain reaction solution；
Step 5: reaction solution in step 4 is taken to repeat Step 2: step 3 and step 4 are reacted, circular response is generated
Iron sucrose.
The ferrous salt is any one of ferrous sulfate heptahydrate, iron chloride or ferrous carbonate；
The concentration of the sodium hydrate aqueous solution is 0.1-2mol/L.
The sucrose complex is as feed addictive, and for the feeding of pig, chicken, duck, ox and sheep, additive amount is
300g/ tons of feeds.
There are a pair of of lone pair electrons, while transition metal ions (M=Cu on the glycosidic bond of sucrose (few disaccharides)2+、Zn2+、 Mn2 +、Fe2+、Ca2+) there is suitable unoccupied orbital, under suitable temperature environment " coordination effect ", after chemical reaction can be formed with sucrose
Complexing forms complex state metal, is absorbed and utilized conducive to animal body.It is as follows that it forms molecular structural formula:
Above-mentioned formula is sucrose microelement molecular structural formula, wherein M=Cu2+、Zn2+、Mn2+、Fe2+、Ca2+。
Because the reaction of sucrose trace-element complex is complicated, product is different from general amino-acid chelate, belong to more
In macromolecular structure, the molecular weight that does not determine.
The above-mentioned mechanism for preparing iron sucrose is by sucrose and Fe2+After reacting forming complex, sucrose complex is utilized
Insoluble in ethyl alcohol, then solid sucrose Complexing Iron is can be obtained in drying to Precipitation.
Inventor is first primary refiltering after iron sucrose solution cooling before ethyl alcohol is added, and its object is to excessive
Microelement is remained in the form of filter residue, as one of sucrose circulation complex reaction object, by filtrate: the weight of 75% ethanol solution
It measures ratio=1: 2 and 75% ethanol solution progress room temperature precipitating is added, principle is: excessive microelement does not dissolve in ethyl alcohol, therefore
It to be filtered this out first before ethyl alcohol is added.The polarity of ethyl alcohol is weaker again, and iron sucrose is polyhydroxy salt, and polarity is larger,
According to the principle of similar intermiscibility, iron sucrose is slightly soluble in ethyl alcohol, and the two is separated, so that it may obtain purer iron sucrose and produce
Product.
The application method of sucrose complex of the present invention is: after mixing with feed, for pig, chicken, duck, ox and sheep
Feeding, additive amount are 300g/ tons of feeds.
Compared with prior art, the positive effect of the present invention is:
1, sucrose complex of the present invention obtains iron sucrose solution by the complex reaction of sucrose and ferrous salt, is being added
It will be refiltered once after iron sucrose solution cooling before ethyl alcohol, and filter residue and filtrate be obtained, by filtrate: the weight of 75% ethanol water
After measuring ratio=1: 2 addition 75% ethanol water progress room temperature precipitating, precipitating centrifugation is filtered, is dried in vacuo and dries, screening, inspection
It surveys, obtains purer sucrose iron product；The iron concentration of two filter residue of detecting step, according to the molar ratio of sucrose and iron ion
For 1:4, sucrose and ferrous salt are continuously added, step 3 is centrifuged filtered waste water and is returned in reaction kettle as dissolving saccharose
Mother liquor, with identical reaction condition carry out circular response continue generate iron sucrose.The present invention prepares the process of iron sucrose, is one
The chemical process of a circular response realizes the recycling of the energy, meets the requirement of Green Chemistry, reduces production cost,
Improve production efficiency.
2, sucrose complex of the present invention, due to sucrose addition and have fine palatability good, slight sugar sweet fragrance makes
It obtains livestock and poultry and likes feeding.
3, the present invention is using sucrose as primary raw material, obtained iron sucrose, uses amino-acid complex (chelating) micro member with simple
Cost used in element is compared, and present invention reduces the use costs of 20-30%.
4, the complex compound of iron sucrose of the present invention, dissolubility is good, it is easy absorb, stability it is good, can be obvious as feed addictive
The excrement excretion of feed source microelement is reduced, pollution of the aquaculture to environment is reduced, moreover it is possible to improve meat yellowish pink, enhance body
Anti-oxidation function, significantly improve the vigor of liver, GSH-Px in muscle, improve serum T-AOC and T-SOD, reduce UN, show
Writing improves the Nutrient Apparent Digestibilities such as feed CP, EE, iron, phosphorus, increases the deposition of nitrogen, moreover it is possible to significantly improve serum levels of iron and liver iron contains
Amount.After iron sucrose enters in animal stomach, absorbable Organic Iron is generated with gastric acid slow reaction.
5, the complex compound of iron sucrose of the present invention, organic trace element amount ratio inorganic ions is few, and absorption rate is high
It 3-4 times out, not will cause waste, while problem of environmental pollution is improved, the safety of people be improved.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And it can be implemented in accordance with the contents of the specification, and in order to allow above and other objects, features and advantages of the invention can
It is clearer and more comprehensible, below in conjunction with preferred embodiment, detailed description are as follows.
Specific embodiment
The following detailed description of a specific embodiment of the invention, as part of this specification, by embodiment come
Illustrate that the principle of the present invention, other aspects of the present invention, feature and its advantage will become apparent by the detailed description.
Embodiment 1
The preparation method of sucrose complex includes the following steps:
Step 1: add the sucrose of 25 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 40 parts by weight, adding sodium hydroxide
It is water-soluble basified, adjust the pH 11 of solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 65 DEG C, adds 80 parts by weight ferrous sulfate heptahydrates and carry out network
Reaction 1 hour is closed, reaction process is stirred continuously, and generates iron sucrose solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: pressing filtrate: weight ratio=1 of 75% ethanol water: 2, which are added 75% ethanol water progress room temperature, sinks
It forms sediment, the sedimentation time is 1.5 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sediment is vacuum dried,
Detection obtains iron sucrose product；
Step 4: taking the iron concentration of filter residue in step 2, it is 1:4 according to the molar ratio of sucrose and iron ion, continues
25 parts by weight of sucrose and 20 parts by weight ferrous sulfate heptahydrates (iron concentration here has 60 parts by weight) are added, centrifugation filters
Waste water afterwards returns to the mother liquor in reaction kettle as dissolving saccharose, and adding sodium hydroxide is water-soluble basified, adjusts the pH 11 of solution
Obtain reaction solution；
Step 5: reaction solution in step 4 is taken to heat reaction kettle, keeps temperature in the kettle in 65 DEG C of progress complex reactions, repeat
Step 2: step 3 and step 4 are reacted, circular response generates iron sucrose.
Embodiment 2
The preparation method of sucrose complex includes the following steps:
Step 1: add the sucrose of 29 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 45 parts by weight, adding sodium hydroxide
Water-soluble basified, the pH 11 for adjusting solution obtains reaction solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 70 DEG C, adds 40 parts by weight iron chloride and carry out complex reaction
1.5 hours, reaction process was stirred continuously, and generated iron sucrose solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: pressing filtrate: weight ratio=1 of 75% ethanol water: 2, which are added 75% ethanol water progress room temperature, sinks
It forms sediment, the sedimentation time is 2 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sediment is vacuum dried, inspection
It surveys and obtains iron sucrose product；
Step 4: taking the iron concentration of filter residue in step 2, it is 1:4 according to the molar ratio of sucrose and iron ion, continues
29 parts by weight of sucrose and 15 parts by weight iron chloride (25 parts by weight of iron concentration here) are added, after step 3 centrifugation is filtered
Waste water back to the mother liquor in reaction kettle as dissolving saccharose, adding sodium hydroxide is water-soluble basified, adjust the pH 11 of solution,
Obtain reaction solution；
Step 5: taking reaction solution in step 4, reaction kettle is heated, keeps temperature in the kettle in 70 DEG C of progress complex reactions, weight
Again Step 2: step 3 and step 4 are reacted, circular response generates iron sucrose.
Embodiment 3
The preparation method of sucrose complex includes the following steps:
Step 1: add the sucrose of 32 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 50 parts by weight, adding sodium hydroxide
It is water-soluble basified, adjust the pH 12 of solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 75 DEG C, adds 42 parts by weight ferrous carbonates and be complexed instead
It answers 2 hours, reaction process is stirred continuously, and generates iron sucrose solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: taking filtrate obtained by step 2, by filtrate: weight ratio=1 of 75% ethanol water: 2 are added 75% second
Alcohol solution carries out room temperature precipitating, and the sedimentation time is 3 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sinks
Starch is vacuum dried, and detection obtains iron sucrose product；
Step 4: taking the iron concentration of filter residue in step 2, it is 1:4 according to the molar ratio of sucrose and iron ion, continues
32 parts by weight of sucrose and 10 parts by weight ferrous carbonates (30 parts by weight of iron concentration here) are added, step 3 is centrifuged and is filtered
Waste water afterwards returns to the mother liquor in reaction kettle as dissolving saccharose, and adding sodium hydroxide is water-soluble basified, adjusts the pH of solution
12, obtain reaction solution；
Step 5: taking reaction solution in step 4, reaction kettle is heated, keeps temperature in the kettle in 75 DEG C of progress complex reactions, weight
Again Step 2: step 3 and step 4 are reacted, circular response generates iron sucrose.
Application implementation test
1, experiment is divided to two groups: the iron sucrose of experimental group is the self-control of Nanning City Ze Weier Co., Ltd, and control group is inorganic
Ferrous sulfate is that commercial sulfuric acid is ferrous.
2, experimental animal: sow and piglet
3, experimental design: the amount of iron sucrose and ferrous sulfate is added in feed, such as table 1.
Iron sucrose and ferrous sulfate is added in table 1 in feed
| Project | Iron sucrose | Ferrous sulfate |
| Sow | 50mg/kg | 50mg/kg |
| Piglet | 50mg/kg | 50mg/kg |
4, feeding management: nursery house uses slatted floor child care equipment, and at 22-25 DEG C, relative humidity controls house temperature control system
In 65%- 75%.Experiment the last week is cleaned, washed away and is sterilized to pig house and various feeding utensils, sprays ground with caustic soda
The facilities such as face, fence, trough keep colony house ventilation, cleaning, drying during experiment.
5, testing index and method
Daily gain, feed efficiency, feedstuff-meat ratio, the feed intake in each period etc..
6, experimental result
1), sugarcane is added in the diet of the latter half of gestation of sow and entire lactation period (farrowing first 7 days to lactation the 26th day)
Sugared iron, obtained result such as table 2.
The difference of iron sucrose and ferrous sulfate is added in the latter half of gestation and the diet of entire lactation period of 2 sow of table
| Project | Iron sucrose group | Ferrous sulfate group |
| Sow head number/head | 50 | 50 |
| Gestational period feed intake/pound | 506±8.2 | 512±8.3 |
| Lactation period feed intake/pound | 248±15.6 | 253±15.7 |
| Lactation period/day | 18.6±0.5 | 18.8±0.5 |
| Sow lactation period weightlessness/pound | 10.6±4.8 | 10.1±4.9 |
| Nest litter size/head | 10.2±0.5 | 10±0.4 |
| The number of live birth/head | 9.8±0.5 | 9.6±0.5 |
2) 50 sows, are divided into two groups, add iron sucrose and ferrous sulfate respectively in diet, additive amount is
50mg/kg.30 days are observed after the sow gestation phase to the 20th day lactation period piglet death rate and nest number pigs weaned, as a result such as table
3。
After the 3 sow gestation phase of table 30 days to the 20th day lactation period piglet death rate and nest number pigs weaned
| Project | Nest number pigs weaned/head | The death rate/% |
| Iron sucrose group | 9.2 | 1.42 |
| Ferrous sulfate group | 8.86 | 2.56 |
The result shows that two experimental group nest number pigs weaned differences are little, but the piglet death rate that iron sucrose group is added is obvious
It reduces.
3) 50 weanling pigs similar in weight, are randomly assigned into two groups, one group adds iron sucrose (additive amount 200mg/
Kg), add ferrous sulfate (additive amount 200mg/kg) for one group, the results showed that the daily gain of iron sucrose group is slightly above ferrous sulfate
Group, but then difference is somewhat big for feed-weight ratio, such as table 4.
The weight gain relationship of 4 different feeds of table feeding piglet
| Project | Iron sucrose group | Ferrous sulfate group |
| Number pigs weaned/head | 25 | 25 |
| Starting weight/kg | 17.96±3.11 | 17.62±3.54 |
| End weight/kg | 54.81±4.25 | 54.23±5.12 |
| Weight gain/kg | 36.45±2.11 | 35.79±1.52 |
| Daily gain/kg | 601±36.51 | 596±25.68 |
| Total augment weight/kg | 652.8 | 643.2 |
| Total feed consumption weight/kg | 1720.23 | 1782.59 |
| Feed-weight ratio | 2.63 | 2.77 |
7, brief summary
Iron sucrose is added in the diet of pregnant sow can effectively reduce the death rate of birth piglet and weanling pig, have
The effect for improving piglet weight gain, reducing the death rate, increasing weanling pig head number, reduce feed intake, shorten lactation period.
Compared with prior art, the positive effect of the present invention is:
1, sucrose complex of the present invention obtains iron sucrose solution by the complex reaction of sucrose and ferrous salt, is being added
It will be refiltered once after iron sucrose solution cooling before ethyl alcohol, and filter residue and filtrate be obtained, by filtrate: the weight of 75% ethanol water
After measuring ratio=1: 2 addition 75% ethanol water progress room temperature precipitating, precipitating centrifugation is filtered, is dried in vacuo and dries, screening, inspection
It surveys, obtains purer sucrose iron product；The iron concentration of two filter residue of detecting step, according to the molar ratio of sucrose and iron ion
For 1:4, sucrose and ferrous salt are continuously added, step 3 is centrifuged filtered waste water and is returned in reaction kettle as dissolving saccharose
Mother liquor, with identical reaction condition carry out circular response continue generate iron sucrose.The present invention prepares the process of iron sucrose, is one
The chemical process of a circular response realizes the recycling of the energy, meets the requirement of Green Chemistry, reduces production cost,
Improve production efficiency.
2, sucrose complex of the present invention, due to sucrose addition and have fine palatability good, slight sugar sweet fragrance makes
It obtains livestock and poultry and likes feeding.
3, the present invention is using sucrose as primary raw material, obtained iron sucrose, uses amino-acid complex (chelating) with simple
Cost used in microelement is compared, and present invention reduces the use costs of 20-30%.
4, the complex compound of iron sucrose of the present invention, dissolubility is good, it is easy absorb, stability it is good, can be obvious as feed addictive
The excrement excretion of feed source microelement is reduced, pollution of the aquaculture to environment is reduced, moreover it is possible to improve meat yellowish pink, enhance body
Anti-oxidation function, significantly improve the vigor of liver, GSH-Px in muscle, improve serum T-AOC and T-SOD, reduce UN, show
Writing improves the Nutrient Apparent Digestibilities such as feed CP, EE, iron, phosphorus, increases the deposition of nitrogen, moreover it is possible to significantly improve serum levels of iron and liver iron contains
Amount.After iron sucrose enters in animal stomach, absorbable Organic Iron is generated with gastric acid slow reaction.
5, the complex compound of iron sucrose of the present invention, organic trace element amount ratio inorganic ions is few, and absorption rate is high
It 3-4 times out, not will cause waste, while problem of environmental pollution is improved, the safety of people be improved.
The above is a preferred embodiment of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, it is noted that for those skilled in the art, without departing from the principle of the present invention, may be used also
To make several improvement and variation, these, which improve and change, is also considered as protection scope of the present invention.
Claims (2)
1. a kind of preparation method of sucrose complex, which comprises the steps of:
Step 1: sucrose and water are uniformly mixed according to the ratio of weight fraction 25-32:40-50, according to sucrose and ferrous salt
Weight fraction is that ferrous salt is added in 25-32:20-30, and sodium hydrate aqueous solution adjusting pH11-12 is added and obtains reaction solution；
Step 2: reaction solution obtained by step 1 is kept the temperature 1-2 hours under the conditions of 65-75 DEG C of temperature, being stirred continuously, cold filtration
Separation, obtains filter residue and filtrate；
It is 1: 2 75% ethyl alcohol of addition by the weight ratio of filtrate and 75% ethanol water Step 3: taking filtrate obtained by step 2
Aqueous solution room temperature precipitates 1.5-3 hours, and sediment is filtered by centrifugation, obtained waste water and sediment, and sediment is dry through vacuum
Dry, detection obtains iron sucrose product；
It is 1:4 according to the molar ratio of sucrose and iron ion Step 4: taking filter residue in step 2 and detecting iron concentration therein
Sucrose and molysite are added into filter residue, takes step 3 to be centrifuged the filter residue that sucrose and ferrous salt is added in filtered waste water dissolution, adds
The pH 11-12 that sodium hydrate aqueous solution adjusts solution obtains reaction solution；
Step 5: reaction solution in step 4 is taken to repeat Step 2: step 3 and step 4 are reacted, circular response generates sucrose
Iron；
The ferrous salt is any one of ferrous sulfate heptahydrate, iron chloride or ferrous carbonate；
The concentration of the sodium hydrate aqueous solution is 0.1-2mol/L.
2. the preparation method of sucrose complex as described in claim 1, it is characterised in that: the sucrose complex conduct
Feed addictive, for the feeding of pig, chicken, duck, ox and sheep, additive amount is 300g/ tons of feeds.
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| CN107319164A (en) * | 2017-08-22 | 2017-11-07 | 南宁市泽威尔饲料有限责任公司 | A kind of complex compound of secondary Complexing Iron and its production and use |
| CN107712357A (en) * | 2017-11-21 | 2018-02-23 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary Complexing Iron and preparation method thereof |
| CN109912675B (en) * | 2017-12-13 | 2020-09-15 | 北京市林业果树科学研究院 | Ferrous sucrose and preparation method thereof |
| CN111592572A (en) * | 2020-05-15 | 2020-08-28 | 侯西成 | Preparation method and equipment of green and environment-friendly iron sucrose bulk drug |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101671373A (en) * | 2009-10-10 | 2010-03-17 | 天津中敖生物科技有限公司 | Preparation method for iron sucrose bulk drug and injection thereof |
| EP1733058B1 (en) * | 2004-03-16 | 2012-09-05 | Navinta, llc. | Iron sucrose complexes and method of manufacture thereof |
| CN103040730A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron sucrose injection and preparation method thereof |
| CN104206735A (en) * | 2014-09-13 | 2014-12-17 | 南宁市泽威尔饲料有限责任公司 | Microelement sucrose complex feed additive as well as preparation method and application thereof |
| CN105145253A (en) * | 2015-09-10 | 2015-12-16 | 南宁市马山县福源生态农业发展有限公司 | Method for planting organic passion fruit trees |
| CN105394351A (en) * | 2015-10-27 | 2016-03-16 | 南宁市泽威尔饲料有限责任公司 | Oligosaccharide chelated composite trace element mineral matter supplement and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030480B2 (en) * | 2004-12-06 | 2011-10-04 | Emcure Pharmaceuticals Limited | Cost-effective process for preparation of manufacture of iron sucrose |
-
2016
- 2016-08-01 CN CN201610613959.1A patent/CN106243162B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1733058B1 (en) * | 2004-03-16 | 2012-09-05 | Navinta, llc. | Iron sucrose complexes and method of manufacture thereof |
| CN101671373A (en) * | 2009-10-10 | 2010-03-17 | 天津中敖生物科技有限公司 | Preparation method for iron sucrose bulk drug and injection thereof |
| CN103040730A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron sucrose injection and preparation method thereof |
| CN104206735A (en) * | 2014-09-13 | 2014-12-17 | 南宁市泽威尔饲料有限责任公司 | Microelement sucrose complex feed additive as well as preparation method and application thereof |
| CN105145253A (en) * | 2015-09-10 | 2015-12-16 | 南宁市马山县福源生态农业发展有限公司 | Method for planting organic passion fruit trees |
| CN105394351A (en) * | 2015-10-27 | 2016-03-16 | 南宁市泽威尔饲料有限责任公司 | Oligosaccharide chelated composite trace element mineral matter supplement and preparation method thereof |
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