CN101671373A - Preparation method for iron sucrose bulk drug and injection thereof - Google Patents
Preparation method for iron sucrose bulk drug and injection thereof Download PDFInfo
- Publication number
- CN101671373A CN101671373A CN200910070762A CN200910070762A CN101671373A CN 101671373 A CN101671373 A CN 101671373A CN 200910070762 A CN200910070762 A CN 200910070762A CN 200910070762 A CN200910070762 A CN 200910070762A CN 101671373 A CN101671373 A CN 101671373A
- Authority
- CN
- China
- Prior art keywords
- solution
- sucrose
- iron
- preparation
- bulk drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a preparation method for an iron sucrose bulk drug. The method comprises the following steps: (1) crystallization: the pH value of sucrose solution is adjusted to 1-4 with acetic acid, iron salt solution is added to the sucrose solution to form mixed liquor, the pH value of the mixed liquor is adjusted to 1-3 with Na2CO3 solution, then the mixed liquor is stirred and is continued to be added with the Na2CO3 solution until turbidity appears in the mixed liquor, the pH value of the mixed liquor is adjusted to 4-7, and then the mixed liquor is filtered and added with water to obtain iron cake solution; (2) complexing: the sucrose solution is heated and added with alkaline liquor for alkalization, and then the alkalized sucrose solution is added with the iron cake solution and stands for the night to obtain complexing solution; and (3) refining: the complexing solution after standing for the night is filtered, and the filtrate precipitates with 2-3 times of 95 percent of ethanol and is filtered to obtain the iron sucrose bulk drug. The invention has the advantages of simple process steps, easy control of the reaction processes, good product quality, high yieldand lower production cost and is a high-novelty preparation method for the iron sucrose bulk drug and the injection thereof.
Description
Technical field
The invention belongs to piglet benefit chalybeate field in the livestock breeding industry, the preparation method of especially a kind of iron sucrose bulk drug and injection liquid.
Background technology
In the feeding process of piglet, the picked-up of ferro element is very important, ferro element is the necessary a kind of trace element of body, is the requisite composition of body synthetic hemoglobin, equally also is moietys such as myohaemoglobin, cytopigment, cytopigment enzyme, peroxidase.The primary iron deficiency can cause the newborn piglet anaemia, the piglet death of tool statistics about 30% is owing to iron deficiency causes, anaemic piglet mainly occurred in for 2～4 ages in week, and piglet growth is fast more, it is fast more that the ferro element reserves consume, and the sickness rate of anaemia is also just high more.If untimely additional ferro element, can bring following unfavorable factor to piglet: (1) can not form oxyphorase, myohaemoglobin, cytopigment enzyme and multiple peroxidase, thereby influences the conveying of endotrophic material; (2) content of hemoglobin is low, takes oxygen, oxygen delivery capacity is low, causes biological organs depletion easily; (3) sickness rate such as diarrhea, oedema, white muscle disease raise, poor growth, and dorsal body setae is slightly random, skin and mucosal pallor, poor appetite; (4) physiological function descends, hypoimmunity, easy infection generation secondary disease.
Be applied to clinical piglet benefit iron medicine at present and be mainly Iron Dextran, though this medicine can be effective in cure to the piglet hypoferric anemia, but there are the following problems for prolonged application: the synthetic of Iron Dextran is a very complicated process, generally carrying out complex reaction with ferric hydroxide and dextran molecule makes, this complex reaction is very unstable, is subjected to the pH value and the FeCl of reaction system
3The influence of strength of solution is bigger, and product yield is lower, second-rate, and the dextran material cost is higher, causes finished medicines to hold at high price, and has influenced its clinical application to a certain extent.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of iron sucrose bulk drug, the good product quality that this preparation method obtains, yield height, production cost is lower, and reaction process is easy to control.
Another object of the present invention is to provide a kind of preparation method of sucrose rail injection liquid
A kind of preparation method of iron sucrose bulk drug the steps include:
(1) crystallization: the pH value that with acetic acid with concentration is 50%～80% sucrose solution transfers to 1～4, is that the iron salt solutions of 0.1mol/L～10mol/L joins and forms mixed solution in the sucrose solution with concentration, is 30%～50% Na with concentration
2CO
3Solution transfers to 1～3 with the pH value of this mixed solution, stirs 20～40 minutes, and continuation adding concentration is 20%～50% Na
2CO
3The pH value that muddiness and mixed solution appear to the mixed solution in solution transfers to 4～7, filters, and adds entry in the crystallization that filtration obtains the crystallization dissolving is got final product, and obtains discus solution;
(2) complexing: with concentration is the heating of 50%～80% sucrose solution, temperature is controlled at 90～120 ℃, adding concentration then is that 20～40% alkali lye alkalize, pH value is controlled at 10～14, alkalizes 10～30 minutes, adds discus solution in the sucrose solution after alkalization, after the complexing 1～3 hour, be cooled in half an hour below 30～60 ℃, static spending the night obtains complex liquid;
(3) refining: the complex liquid after static the spending the night is filtered, and filtrate is with 2～3 times 95% ethanol sedimentation, filtration, and the throw out that obtains is soluble in water, uses ethanol sedimentation again, and throw out is dried under 50～70 ℃ of conditions, is iron sucrose bulk drug.
And the volume ratio of sucrose solution and iron salt solutions is in the described step (1): 2: 1～10: 1.
And the volume of sucrose solution and discus solution is in the described step (2): 2: 1～10: 1.
And described iron salt solutions is liquor ferri trichloridi, iron nitrate solution, ironic citrate solution, iron acetate solution, Iron triperchlorate's solution, ironic citrate ammonium solution, ferric ammonium nitrate solution or Phosphoric acid glycerol esters ferrous solution wherein a kind of.
And described alkali lye is the wherein a kind of of sodium hydroxide solution, sodium carbonate solution, potassium hydroxide solution, solution of ammonium hydroxide or solution of potassium carbonate.
A kind of preparation method of sucrose rail injection liquid, wherein the iron sucrose bulk drug that the preparation method according to above-mentioned iron sucrose bulk drug is obtained joins and is mixed with every milliliter of solution that contains ferro element 100～300mg in the water for injection, the NaOH solution of adding 20～40% alkalizes, pH value is controlled at 11, heating and temperature control is at 40～80 ℃, and then add 1～3 ‰ gac, stir 15～60 minutes after-filtration, after the filtrate degerming and removing insoluble particle, carry out the filtrate sterilization, promptly get sucrose rail injection liquid finished product.
And described degerming and insoluble particle are for using the 0.22um micro-filtrate membrane filtration.
And described filtrate sterilization is controlled at 110～120 ℃ for filtrate is filled in the container with the steam heating temperature, keeps 30 minutes.
And described water for injection is conventional aseptic deionization water for injection.
Invention is achieved through the following technical solutions:
Advantage of the present invention and beneficial effect are:
1, to adopt the very cheap sucrose of cost be raw material to the preparation method of this iron sucrose bulk drug and injection liquid, stability is better in the production, and is water-soluble higher, can absorb with molecular form, toxic side effect is that the ideal that meets international standard is mended chalybeate less than traditional Iron Dextran.
2, the preparation method of this sucrose rail injection liquid is guidance with the nanotechnology, with sucrose and trivalent iron salt is main raw material, through synthesis of hydroxy ferric oxide iron parent nucleus, and then obtain sucrose rail injection liquid with the sucrose part complexing of alkalization, refining, preparation and sterilization, this injection liquid can effectively improve the piglet blood content of hemoglobin, increase the body weight of piglet fast, improve the survival rate of piglet.
3, the preparation method of this iron sucrose bulk drug can improve the content of iron ion in the bulk drug, strengthens the stability of iron ion in bulk drug, reduces injected dose and frequency injection, improves therapeutic efficiency and result of treatment.
4, the preparation method of this sucrose rail injection liquid can improve injection stability, is beneficial to absorption, can significantly improve result of treatment.
5, processing step of the present invention is simple, reaction process is easy to control, good product quality, yield height, and production cost is lower, is the preparation method of higher iron sucrose bulk drug of a kind of novelty and injection liquid.
Embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of preparation method of iron sucrose bulk drug the steps include:
(1), crystallization: the pH value that with acetic acid with concentration is 60% sucrose solution transfers to 1.5, with concentration is that the iron salt solutions 50ml of 1mol/L joins in the 100ml sucrose solution and forms mixed solution, iron salt solutions is liquor ferri trichloridi, iron nitrate solution, ironic citrate solution, iron acetate solution, Iron triperchlorate's solution, ironic citrate ammonium solution, ferric ammonium nitrate solution or Phosphoric acid glycerol esters ferrous solution wherein a kind of, the present embodiment iron salt solutions adopts liquor ferri trichloridi, is 30% Na with concentration
2CO
3Solution transfers to 1.7 with the pH value of mixed solution, stirs 30 minutes, and continuation adding concentration is 30% Na
2CO
3Solution has just had the pH value of muddiness and mixed solution to transfer to 4 to mixed solution, filters, and obtains adding in the crystallization entry to filtration the crystallization dissolving is got final product, and obtains discus solution;
(2), complexing: with concentration is the sucrose solution heating of 60%100ml, temperature is controlled at 100 ℃, adding concentration then is the alkalization of 20～40% alkali lye, described alkali lye is the wherein a kind of of sodium hydroxide solution, sodium carbonate solution, potassium hydroxide solution, solution of ammonium hydroxide, solution of potassium carbonate, it is that 20% NaOH solution alkalizes that present embodiment adopts concentration, the pH value control transfers to 11, alkalize and add discus solution 50ml after 15 minutes, after the complexing 2 hours, in half an hour, be cooled to below 50 ℃, after static the spending the night, obtain complex liquid;
(3), refining: the complex liquid after static the spending the night is filtered, and filtrate is with 2 times 95% ethanol sedimentation, and filtration obtains the throw out ethanol sedimentation of using again soluble in water, and throw out is dried under 60 ℃ of conditions, is iron sucrose bulk drug.
A kind of preparation method of sucrose rail injection liquid, wherein the iron sucrose bulk drug that the preparation method according to above-mentioned iron sucrose bulk drug is obtained joins and is mixed with every milliliter of solution that contains ferro element 150mg in the water for injection, described water for injection is conventional aseptic deionization water for injection, the NaOH solution of adding 20% alkalizes, pH value transfers to 11, heating and temperature control is at 60 ℃, and then add 2 ‰ gac, stir 30 minutes after-filtration, with the filtrate degerming and except that insoluble particle, degerming and insoluble particle are for using the 0.22um micro-filtrate membrane filtration, carry out the filtrate sterilization, filtrate is sterilized to filtrate is filled in the container, is controlled at 115 ℃ with the steam heating temperature, kept 30 minutes, and promptly got sucrose rail injection liquid finished product.
Embodiment 2
A kind of preparation method of iron sucrose bulk drug the steps include:
(1), crystallization: the pH value that with acetic acid with concentration is 50% sucrose solution transfers to 1, with concentration is that the iron salt solutions 30ml of 10mol/L joins in the 300ml sucrose solution and forms mixed solution, iron salt solutions is liquor ferri trichloridi, iron nitrate solution, ironic citrate solution, iron acetate solution, Iron triperchlorate's solution, ironic citrate ammonium solution, ferric ammonium nitrate solution or Phosphoric acid glycerol esters ferrous solution wherein a kind of, present embodiment adopts iron nitrate solution, is 30% Na with concentration
2CO
3Solution transfers to 1 with the pH value of mixed solution, stirs 20 minutes, and continuation adding concentration is 20% Na
2CO
3Solution has just had the pH value of muddiness and mixed solution to transfer to 4 to mixed solution, filters, and adds entry in obtaining crystallization the crystallization dissolving is got final product, and obtains discus solution;
(2), complexing: with concentration is the sucrose solution heating of 50%300ml, temperature is controlled at 90 ℃, add concentration then and be the alkalization of 20% alkali lye, described alkali lye is the wherein a kind of of sodium hydroxide solution, sodium carbonate solution, potassium hydroxide solution, solution of ammonium hydroxide, solution of potassium carbonate, and present embodiment adopts potassium hydroxide solution, pH value is controlled at 10, alkalizing adds discus solution 30ml after 10 minutes, complexing was cooled in half an hour below 30 ℃ after 1 hour, after static the spending the night, obtain complex liquid;
(3), refining: the complex liquid after static the spending the night is filtered, and filtrate is with 2 times 95% ethanol sedimentation, and filtration obtains the throw out ethanol sedimentation of using again soluble in water, and throw out is dried under 50 ℃ of conditions, is iron sucrose bulk drug.
A kind of preparation method of sucrose rail injection liquid, wherein the iron sucrose bulk drug that the preparation method according to above-mentioned iron sucrose bulk drug is obtained joins and is mixed with every milliliter of solution that contains ferro element 100mg in the water for injection, water for injection is conventional aseptic deionization water for injection, the NaOH solution of adding 20% alkalizes, pH value is controlled at 11, heating and temperature control is at 40 ℃, and then add 1 ‰ gac, stir 15 minutes after-filtration, with the filtrate degerming and except that insoluble particle, degerming and insoluble particle are for using the 0.22um micro-filtrate membrane filtration, carry out the filtrate sterilization again, the filtrate sterilization is controlled at 110 ℃ for filtrate is filled in the container with the steam heating temperature, keeps promptly getting in 30 minutes sucrose rail injection liquid finished product.
Embodiment 3
A kind of preparation method of iron sucrose bulk drug is characterized in that: steps of the method are:
(1), crystallization: the pH value that with acetic acid with concentration is 80% sucrose solution transfers to 4, with concentration is that the iron salt solutions 60ml of 1mol/L joins in the 120ml sucrose solution and forms mixed solution, iron salt solutions is liquor ferri trichloridi, iron nitrate solution, ironic citrate solution, iron acetate solution, Iron triperchlorate's solution, ironic citrate ammonium solution, ferric ammonium nitrate solution or Phosphoric acid glycerol esters ferrous solution wherein a kind of, present embodiment adopts Iron triperchlorate's solution, is 50% Na with concentration
2CO
3Solution transfers to 3 with the pH value of mixed solution, stirs 40 minutes, and continuation adding concentration is 50% Na
2CO
3Solution has just had the pH value of muddiness and mixed solution to transfer to 7 to mixed solution, filters, and adds entry in obtaining crystallization the crystallization dissolving is got final product, and obtains discus solution;
(2), complexing: with concentration is the sucrose solution heating of 80%200ml, temperature is controlled at 120 ℃, adding concentration then is the alkalization of 40% alkali lye, and alkali lye is the wherein a kind of of sodium hydroxide solution, sodium carbonate solution, potassium hydroxide solution, solution of ammonium hydroxide or solution of potassium carbonate, and present embodiment adopts solution of ammonium hydroxide, pH value is controlled at 14, alkalizing adds discus solution 40ml after 30 minutes, complexing was cooled in half an hour below 60 ℃ after 3 hours, after static the spending the night, obtain complex liquid;
(3), refining: the complex liquid after static the spending the night is filtered, and filtrate is with 3 times 95% ethanol sedimentation, and filtration obtains the throw out ethanol sedimentation of using again soluble in water, and throw out is dried under 70 ℃ of conditions, is iron sucrose bulk drug.
A kind of preparation method of sucrose rail injection liquid, wherein the iron sucrose bulk drug that the preparation method according to above-mentioned iron sucrose bulk drug is obtained joins and is mixed with every milliliter of solution that contains ferro element 300mg in the water for injection, water for injection is conventional aseptic deionization water for injection, the NaOH solution of adding 40% alkalizes, pH value is controlled at 11, heating and temperature control is at 80 ℃, and then add 3 ‰ gac, stir 60 minutes after-filtration, after the filtrate degerming and removing insoluble particle, degerming and insoluble particle are for using the 0.22um micro-filtrate membrane filtration, carry out the filtrate sterilization, filtrate is sterilized to filtrate is filled in the container, is controlled at 120 ℃ with the steam heating temperature, kept 30 minutes, and promptly got sucrose rail injection liquid finished product.
The relative molecular mass of iron sucrose bulk drug of the present invention detects: utilize gel permeation chromatography (gelpermeation chromatography, GPC) detect, make typical curve with 7 standard relative molecular mass dextrans, average weight-molecular mass is from 4,000～430,000, stratographic analysis moving phase is pure water, sample quality concentration 1g/L, flow velocity 0.16mL/min, 40 ℃ of detector temperatures, 60 ℃ of gel chromatography column temperature.According to the American Pharmacopeia requirement, it is 34 that the apparent molecular weight of sucrose iron requires, 000Da～60, and 000Da, the ratio of weight-average molecular weight and number-average molecular weight is less than 1.7.
Iron content is measured the ICP method that adopts in the iron sucrose bulk drug of the present invention: instrument is that U.S. Perkin～Elmer company produces Optima 3300DV, also can be according to beastly officinal detection method in 2005, adopt oxidation～reductometry by comparing, these two kinds of methods detect the iron content basically identical.Equally, the chlorion detection method also can detect and all obtain standard-required by standards of pharmacopoeia.
The application experiment of sucrose rail injection liquid of the present invention:
With the piglet of birth after 2～3 days, every at random nest piglet is divided into two groups.Do experiment for one group, one group of contrast, 1 milliliter of every injection of test group sucrose rail injection liquid, control group is not injected.Each group is all measured its blood content of hemoglobin (g/dl) in testing back two weeks blood sampling; It is all heavy in when test and 21 ages in days wean time-division another name that each organizes piglet, and add up its weightening finish and survival condition.Its result is as shown in the table:
Blood content of hemoglobin table behind the table 1 piggy injection sucrose rail injection liquid:
As can be seen from the above table, injection sucrose rail injection liquid and control group that the present invention developed compare, and oxyphorase increases by 80.9%.
Information slip increases weight behind the table 2 piggy injection sucrose rail injection liquid
| Group | Dosage (ml) | The test fate | A group number (head) | Body weight (kg) before the medicine | Weaning weight (kg) | Total augment weight (kg) | Average weight gain (kg) | Increase and decrease | Contrast % |
| Sucrose iron | ??1 | ??20 | ??78 | ??120.4 | ??900.8 | ??790.4 | ??10.13 | ??+3.08 | ??143.6 |
| Control group | ??0 | ??20 | ??70 | ??106.6 | ??600.2 | ??493.6 | ??7.05 | ??0 | ??100 |
As known from Table 2, day weight gain increases by 43.6% behind the piggy injection sucrose rail injection liquid.
Survival condition table behind the table 3 piggy injection sucrose rail injection liquid
| Group | Dosage (ml) | The test fate | A group number (head) | A survival number (head) | Survival rate (%) | Increase and decrease | Contrast % |
| Sucrose iron | ??1 | ??20 | ??86 | ??82 | ??95.3 | ??+5.1 | ??105.6 |
| Control group | ??0 | ??20 | ??82 | ??74 | ??90.2 | ??0 | ??100 |
As known from Table 3, survival rate increases by 5.6% behind the piggy injection sucrose rail injection liquid.
The present invention makes sucrose rail injection liquid and homemade benefit chalybeate " domestic animal sanguinin " (iron dextran inj) experiment contrast is as follows:
The different iron preparation piglet blood content of hemoglobin tables of table 1 injection:
As seen from the above table, the blood content of hemoglobin is high by 12.8% than domestic animal sanguinin group behind the piglet intramuscular injection sucrose rail injection liquid.
The different chalybeate weightening finish tables of mending of table 2 piggy injection:
| Group | Iron-holder mg/ml | Dosage ml | The test fate | A group number (head) | Body weight (kg) before the medicine | Weaning weight (kg) | Total augment weight (kg) | Average weight gain (kg) | Increase and decrease | Contrast % |
| Sucrose iron | ??150 | ??1 | ??20 | ??80 | ??126.8 | ??925.6 | ??798.8 | ??9.99 | ??+0.4 | ??104 |
| The domestic animal sanguinin | ??150 | ??1 | ??20 | ??72 | ??110.4 | ??801.5 | ??691.1 | ??9.59 | ??0 | ??100 |
As known from Table 2, piggy injection sucrose rail injection liquid compares with injection domestic animal sanguinin (iron dextran inj), and day weight gain increases by 4%.
The different chalybeate survival condition tables of mending of table 3 piggy injection:
| Group | Iron level mg/ml | Dosage ml | The test fate | A group number (head) | A survival number (head) | Survival rate (%) | Increase and decrease | Contrast % |
| Sucrose iron | ??150 | ??1 | ??20 | ??95 | ??92 | ??96.8 | ??+2.5 | ??102.6 |
| The domestic animal sanguinin | ??150 | ??1 | ??20 | ??88 | ??83 | ??94.3 | ??0 | ??100 |
As known from Table 3, piggy injection sucrose rail injection liquid compares with injection domestic animal sanguinin (iron dextran inj), and survival rate increases by 2.6%.
Sucrose rail injection liquid is transparent Vandyke brown colloidal solution, with small white mouse intramuscular injection sucrose rail injection liquid, adopts improvement Karber method to measure medium lethal dose (LD50), and the result is 800.58mg/kg, according to the acute toxicity classification, belongs to actual nontoxic level.
Claims (9)
1, a kind of preparation method of iron sucrose bulk drug is characterized in that: preparation method's step is:
(1) crystallization: the pH value that with acetic acid with concentration is 50%～80% sucrose solution transfers to 1～4, is that the iron salt solutions of 0.1mol/L～10mol/L joins and forms mixed solution in the sucrose solution with concentration, is 30%～50% Na with concentration
2CO
3Solution transfers to 1～3 with the pH value of this mixed solution, stirs 20～40 minutes, and continuation adding concentration is 20%～50% Na
2CO
3The pH value that muddiness and mixed solution appear to the mixed solution in solution transfers to 4～7, filters, and adds entry in the crystallization that filtration obtains the crystallization dissolving is got final product, and obtains discus solution;
(2) complexing: with concentration is the heating of 50%～80% sucrose solution, temperature is controlled at 90～120 ℃, adding concentration then is that 20～40% alkali lye alkalize, pH value is controlled at 10～14, alkalizes 10～30 minutes, adds discus solution in the sucrose solution after alkalization, after the complexing 1～3 hour, be cooled in half an hour below 30～60 ℃, static spending the night obtains complex liquid;
(3) refining: the complex liquid after static the spending the night is filtered, and filtrate is with 2～3 times 95% ethanol sedimentation, filtration, and the throw out that obtains is soluble in water, uses ethanol sedimentation again, and throw out is dried under 50～70 ℃ of conditions, is iron sucrose bulk drug.
2, the preparation method of iron sucrose bulk drug according to claim 1 is characterized in that: the volume ratio of sucrose solution and iron salt solutions is in the described step (1): 2: 1～10: 1.
3, the preparation method of iron sucrose bulk drug according to claim 1 is characterized in that: the volume of sucrose solution and discus solution is in the described step (2): 2: 1～10: 1.
4, the preparation method of iron sucrose bulk drug according to claim 1, it is characterized in that: described iron salt solutions is liquor ferri trichloridi, iron nitrate solution, ironic citrate solution, iron acetate solution, Iron triperchlorate's solution, ironic citrate ammonium solution, ferric ammonium nitrate solution or Phosphoric acid glycerol esters ferrous solution wherein a kind of.
5, the preparation method of iron sucrose bulk drug according to claim 1 is characterized in that: described alkali lye is the wherein a kind of of sodium hydroxide solution, sodium carbonate solution, potassium hydroxide solution, solution of ammonium hydroxide or solution of potassium carbonate.
6, a kind of preparation method of sucrose rail injection liquid, it is characterized in that: the iron sucrose bulk drug that the preparation method according to the described iron sucrose bulk drug of claim 1 is obtained joins and is mixed with every milliliter of solution that contains ferro element 100～300mg in the water for injection, the NaOH solution of adding 20～40% alkalizes, pH value is controlled at 11, heating and temperature control is at 40～80 ℃, and then add 1～3 ‰ gac, stir 15～60 minutes after-filtration, after the filtrate degerming and removing insoluble particle, carry out the filtrate sterilization, promptly get sucrose rail injection liquid finished product.
7, the preparation method of sucrose rail injection liquid according to claim 6 is characterized in that: described degerming and insoluble particle are for using the 0.22um micro-filtrate membrane filtration.
8, the preparation method of sucrose rail injection liquid according to claim 6 is characterized in that: described filtrate sterilization is controlled at 110～120 ℃ for filtrate is filled in the container with the steam heating temperature, keeps 30 minutes.
9, the preparation method of sucrose rail injection liquid according to claim 6 is characterized in that: described water for injection is conventional aseptic deionization water for injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910070762A CN101671373A (en) | 2009-10-10 | 2009-10-10 | Preparation method for iron sucrose bulk drug and injection thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910070762A CN101671373A (en) | 2009-10-10 | 2009-10-10 | Preparation method for iron sucrose bulk drug and injection thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101671373A true CN101671373A (en) | 2010-03-17 |
Family
ID=42018815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910070762A Pending CN101671373A (en) | 2009-10-10 | 2009-10-10 | Preparation method for iron sucrose bulk drug and injection thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101671373A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102362870A (en) * | 2011-11-18 | 2012-02-29 | 陕西盘龙制药集团有限公司 | Injection for treating iron deficiency anemia and preparation method thereof |
| CN103040730A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron sucrose injection and preparation method thereof |
| CN103059072A (en) * | 2013-01-18 | 2013-04-24 | 常州工程职业技术学院 | Preparation method of raw medicine of environment-friendly iron sucrose |
| CN103622979A (en) * | 2012-08-21 | 2014-03-12 | 天津中敖生物科技有限公司 | Preparation method of iron sucrose bulk drug and injection |
| CN103626807A (en) * | 2013-11-20 | 2014-03-12 | 青岛国风药业股份有限公司 | Preparation method and mass detection method of polysaccharide-iron complex |
| CN104206735A (en) * | 2014-09-13 | 2014-12-17 | 南宁市泽威尔饲料有限责任公司 | Microelement sucrose complex feed additive as well as preparation method and application thereof |
| CN106188200A (en) * | 2016-08-01 | 2016-12-07 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose zinc complex |
| CN106220691A (en) * | 2016-08-01 | 2016-12-14 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose manganese complex |
| CN106243177A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of lime saccharate complex |
| CN106243176A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The copper complex formazan preparation method of sucrose |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
| CN106234774A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose magnesium complex |
| CN106543237A (en) * | 2016-11-04 | 2017-03-29 | 嘉实（湖南）医药科技有限公司 | The preparation method of iron sucrose |
| CN107898807A (en) * | 2017-12-18 | 2018-04-13 | 山西威奇达光明制药有限公司 | A kind of iron sucrose injection and preparation method thereof |
| CN109893540A (en) * | 2017-12-07 | 2019-06-18 | 南京恒生制药有限公司 | A kind of preparation method and products thereof of the iron sucrose complex solution of low-heavy metal content |
| CN111592572A (en) * | 2020-05-15 | 2020-08-28 | 侯西成 | Preparation method and equipment of green and environment-friendly iron sucrose bulk drug |
| CN112315902A (en) * | 2019-08-05 | 2021-02-05 | 南京恒生制药有限公司 | Preparation method of iron sucrose injection with low content of volatile iron |
-
2009
- 2009-10-10 CN CN200910070762A patent/CN101671373A/en active Pending
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040730A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron sucrose injection and preparation method thereof |
| CN102362870A (en) * | 2011-11-18 | 2012-02-29 | 陕西盘龙制药集团有限公司 | Injection for treating iron deficiency anemia and preparation method thereof |
| CN103622979A (en) * | 2012-08-21 | 2014-03-12 | 天津中敖生物科技有限公司 | Preparation method of iron sucrose bulk drug and injection |
| CN103059072A (en) * | 2013-01-18 | 2013-04-24 | 常州工程职业技术学院 | Preparation method of raw medicine of environment-friendly iron sucrose |
| CN103059072B (en) * | 2013-01-18 | 2015-08-26 | 常州工程职业技术学院 | A kind of preparation method of iron sucrose bulk drug of environmental protection |
| CN103626807A (en) * | 2013-11-20 | 2014-03-12 | 青岛国风药业股份有限公司 | Preparation method and mass detection method of polysaccharide-iron complex |
| CN104206735A (en) * | 2014-09-13 | 2014-12-17 | 南宁市泽威尔饲料有限责任公司 | Microelement sucrose complex feed additive as well as preparation method and application thereof |
| CN106234774A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose magnesium complex |
| CN106220691B (en) * | 2016-08-01 | 2019-01-18 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose manganese complex |
| CN106243177A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of lime saccharate complex |
| CN106243176A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The copper complex formazan preparation method of sucrose |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
| CN106188200A (en) * | 2016-08-01 | 2016-12-07 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose zinc complex |
| CN106243162B (en) * | 2016-08-01 | 2019-01-25 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
| CN106243177B (en) * | 2016-08-01 | 2019-01-22 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose calcium complex |
| CN106188200B (en) * | 2016-08-01 | 2019-01-18 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose zinc complex |
| CN106220691A (en) * | 2016-08-01 | 2016-12-14 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose manganese complex |
| CN106243176B (en) * | 2016-08-01 | 2019-01-22 | 南宁市泽威尔饲料有限责任公司 | The copper complex formazan preparation method of sucrose |
| CN106543237A (en) * | 2016-11-04 | 2017-03-29 | 嘉实（湖南）医药科技有限公司 | The preparation method of iron sucrose |
| CN109893540A (en) * | 2017-12-07 | 2019-06-18 | 南京恒生制药有限公司 | A kind of preparation method and products thereof of the iron sucrose complex solution of low-heavy metal content |
| CN107898807A (en) * | 2017-12-18 | 2018-04-13 | 山西威奇达光明制药有限公司 | A kind of iron sucrose injection and preparation method thereof |
| CN112315902A (en) * | 2019-08-05 | 2021-02-05 | 南京恒生制药有限公司 | Preparation method of iron sucrose injection with low content of volatile iron |
| CN112315902B (en) * | 2019-08-05 | 2022-05-13 | 南京恒生制药有限公司 | Preparation method of iron sucrose injection with low content of volatile iron |
| CN111592572A (en) * | 2020-05-15 | 2020-08-28 | 侯西成 | Preparation method and equipment of green and environment-friendly iron sucrose bulk drug |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101671373A (en) | Preparation method for iron sucrose bulk drug and injection thereof | |
| CN103040730A (en) | Iron sucrose injection and preparation method thereof | |
| CN102361651A (en) | Stable iron oligosaccharide compound | |
| CN103864950B (en) | A kind of preparation method and applications of low molecule Porphyra haitanensis polysaccharide iron complexes | |
| AU2003226923B2 (en) | iron dextrin compounds for the treatment of iron deficiency anaemia | |
| CN101967205B (en) | Beta-dextriferron composite and preparation method thereof | |
| CN102198151B (en) | Bulk pharmaceutical of swine astragalus polyferose and preparation method thereof | |
| CN102198152B (en) | Injection containing astragalus polysaccharide-iron complex for swine, and preparation method thereof | |
| CN102210405B (en) | Astragalus-polyferose-containing premix for pigs and preparation method thereof | |
| CN103989630B (en) | Moxifloxacin hydrochloride injection and preparation method thereof | |
| CN106692255B (en) | Brassica oleracea polysaccharide hydrolysate and medical application thereof | |
| CN102429865B (en) | Preparation method of super-micro molecular iron dextran | |
| CN103044571A (en) | Iron dextran bulk drug and preparation method thereof | |
| CN101215338B (en) | Iron isomaltum oligosaccharide and preparing method thereof | |
| CN105924535B (en) | A kind of preparation method of astragalus polyose iron | |
| CN103622979A (en) | Preparation method of iron sucrose bulk drug and injection | |
| CN106478837B (en) | A kind of green algae polysaccharide iron complexes and preparation method thereof that can be used for animals and plants and mend iron | |
| CN102038084B (en) | Premix containing iron sucrose for raising pigs | |
| CN112300299A (en) | Preparation method and application of zinc and calcium polysaccharide complex | |
| CN110183548A (en) | A kind of preparation method and applications of low molecular weight dextran iron | |
| CN103709219A (en) | Tylosin extraction method | |
| CN115531414A (en) | Novel iron sucrose compound and preparation method thereof | |
| CN104721133B (en) | A kind of terramycin preparation and preparation method | |
| CN106036088A (en) | Pig premix containing astragalus membranaceus polysaccharide iron and preparation method of pig premix | |
| CN102258535B (en) | Method for preparing veterinary compound iron dextran injection and influence of veterinary compound iron dextran injection on growth of mice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100317 |