CN106237261A - A kind of for decoction medicine treating gastric cancer and preparation method thereof - Google Patents

Abstract

The invention belongs to technical field of Chinese medicine, purpose is a kind of decoction medicine for treating gastric cancer according to the traditional Chinese medical science, gastric cancer being recognized mechanism and providing, each component of described medicine and mass parts ratio thereof are as follows: Radix Notoginseng 8～16g, Herba Solani Lyrati 25～48g, Fructus Arctii 5～12g, Herba Agrimoniae 10～18g, Radix Achyranthis Bidentatae 5～16g, Pseudobulbus Cremastrae Seu Pleiones 3～6g, the Rhizoma Pinelliae 3～9g, Rhizoma Sparganii 5～10g, Herba Hedyotidis Diffusae 15～32g, Herba Scutellariae Barbatae 15～30g, Radix Asparagi 6～15g, Radix Ophiopogonis 6～16g Flos Sophorae 5～12g, Radix Sophorae Tonkinensis 3～6g, Rhizoma Corydalis 8～16g, the Rhizoma Atractylodis Macrocephalae 3～16g, Bulbus Allii Cepae 50～100g, Rhizoma Curcumae Longae 3～12g；The medicine that the present invention provides is the Chinese prescription of a treating both the principal and secondary aspects of a disease.

Description

A kind of for decoction medicine treating gastric cancer and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicine, be specifically related to a kind of decoction medicine for treating gastric cancer, particularly supply The field of the decoction medicine that patients with gastric cancer uses and preparation method thereof.

Background technology

At present, cancer is that current serious affects one of human health, the principal disease threatening human life.Cancer and heart and brain Angiopathy, together with contingency, constitutes the world today's big cause of death of All Countries three.Therefore, World Health Organization (WHO) is with each Hygiene department of government of state is all classified as capture cancer as a top priority.The method treating cancer in the world mainly has three kinds, and one It is to use surgical excision, removal lesion tissue, prevents cancerous cell from spreading；Two is to use chemotherapy or radiotherapy, to kill cancerous cell ；Three is to use Drug therapy.The method using excision adds the misery of patient, hinders its vigour, and expense is huge.By chemotherapy or The method of radiotherapy, while killing cancerous cell, also injures erythrocyte and leukocyte, and patient suffers untold misery.

Gastric cancer is derived from the malignant tumor of gastric epithelial, is one of modal malignant tumor of digestive tract, and its morbidity can Can be relevant with factors such as living environment, depressed emotion, drinking and eating irregularly, stomach chronic disease long-time stimulus, account for stomach malignancy 95%, ratio shared in human tumor is different with different regions, typically about 10～30%, it is seen that gastric cancer is to threaten people A kind of commonly encountered diseases that class is healthy.The symptom of gastric cancer and precancerous lesion is hidden and without specificity, and therefore early gastric cancer is difficult to find.Thing In reality, the gastric cancer of China only 5%～10% can be by early diagnosis.And gastric cancer middle and advanced stage patient, health is the weakest, health device Official's function reduction, lassitude, immunity degradation, the ability of immunocyte opposing stomach cancer cell infringement, cause stomach cancer cell Diffusion is accelerated, and patient pain deepens, and the transfer case of gastric cancer middle and advanced stage easily occurs, and hepatic metastases, Bone tumour etc. occurs in cancerous cell Situation, makes state of an illness high progression.

Traditional curing gastric cancer mode is performed the operation, radiotherapy, chemotherapy, be all the western medical treatment method of gastric cancer.The treatment of doctor trained in Western medicine is past Toward all there is side effect.The loss for patients with gastric cancer health of performing the operation is very big, easily makes the weakest patient body more empty Weak, thus cause post-operative recovery slow, the cancerous cell of internal residual more fast-growth.Chemicotherapy, utilizes and has stomach cancer cell There are the lonizing radiation of killing action, chemicals, are the therapeutic modality of " treating the poisonous disease with poisonous drugs ".But chemicotherapy is killing the same of cancerous cell Time, can be to human normal immunocyte, normal organ also results in certain injury, Nausea and vomiting occurs, without the disease such as appetite, alopecia Shape, these are all the side effect of western medical treatment.

The history of TCM on Tumor is of long standing and well established, and as an importance of modern combined therapy of tumour, The most increasingly receive publicity.People seek single pharmaceutically active ingredient or compound recipe to treat cancer tool challenge from Chinese traditional herbs Property.Make a general survey of the research direction of world's new drug, mainly research and develop before the eighties last century single chemicals and Preparation, starts to develop biotechnology and natural medicinal plants after the eighties, drug research direction tends to multiformity.In conjunction with existing Theoretical for Development of Chinese Medicine, from improving curative effect of medication, the angle of reduction side effect, carry through Chinese medicine ingredients is carried out screening Taking and/or preparation that compatibility prepares, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.

So, how we just find a kind of medicine that can effectively treat above-mentioned gastric cancer, are that we are badly in need of solving at present Problem.

Summary of the invention

Along with the development of China's Chinese medicine, in treatment gastric cancer, people gradually appreciate Chinese traditional treatment stomach The advantage of cancer, and the advantage such as toxic and side effects is little over the course for the treatment of, expense is low, for the present situation of existing western medical treatment gastric cancer, this The purpose of invention is to be to provide a kind of decoction medicine for treating gastric cancer, and to solve, patients with gastric cancer is the most restorative asks Topic.This medicine is with common Chinese medicine as raw material, has instant effect, the feature such as evident in efficacy, and can effectively treat above-mentioned gastric cancer.

For reaching the purpose of foregoing invention, the technical solution adopted in the present invention is: provide a kind of for treating gastric cancer Decoction medicine and preparation method thereof, it is characterised in that each component of described medicine and mass parts ratio thereof are as follows:

Radix Notoginseng 8～16g, Herba Solani Lyrati 25～48g, Fructus Arctii 5～12g, Herba Agrimoniae 10～18g, Radix Achyranthis Bidentatae 5～16g, Pseudobulbus Cremastrae Seu Pleiones 3～6g, The Rhizoma Pinelliae 3～9g, Rhizoma Sparganii 5～10g, Herba Hedyotidis Diffusae 15～32g, Herba Scutellariae Barbatae 15～30g, Radix Asparagi 6～15g, Chinese scholartree Radix Ophiopogonis 6～16g Spend 5～12g, Radix Sophorae Tonkinensis 3～6g, Rhizoma Corydalis 8～16g, the Rhizoma Atractylodis Macrocephalae 3～16g, Bulbus Allii Cepae 50～100g, Rhizoma Curcumae Longae 3～12g.

A kind of for decoction medicine treating gastric cancer and preparation method thereof, it is characterised in that each component of described medicine And mass parts ratio is as follows:

Radix Notoginseng 10～13g, Herba Solani Lyrati 30～40g, Fructus Arctii 7～11g, Herba Agrimoniae 12～16g, Radix Achyranthis Bidentatae 10～13g, Pseudobulbus Cremastrae Seu Pleiones 4～ 5.5g, the Rhizoma Pinelliae 6～8g, Rhizoma Sparganii 7～9g, Herba Hedyotidis Diffusae 18～28g, Herba Scutellariae Barbatae 18～26g, Radix Asparagi 10～13g, Radix Ophiopogonis 10～ 14g Flos Sophorae 7～11g, Radix Sophorae Tonkinensis 4～5.5g, Rhizoma Corydalis 10～14g, the Rhizoma Atractylodis Macrocephalae 10～14g, Bulbus Allii Cepae 60～85g, Rhizoma Curcumae Longae 8～ 11g。

A kind of for decoction medicine treating gastric cancer and preparation method thereof, it is characterised in that the medicine of described " preferred plan " Each component of thing and mass parts ratio thereof are as follows:

Radix Notoginseng 12g, Herba Solani Lyrati 35g, Fructus Arctii 10g, Herba Agrimoniae 13g, Radix Achyranthis Bidentatae 12g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Pinelliae 7g, Rhizoma Sparganii 8g, Agkistrodon SHECAO 25g, Herba Scutellariae Barbatae 25g, Radix Asparagi 12g, 13g Flos Sophorae 10g Radix Ophiopogonis, Radix Sophorae Tonkinensis 5g, Rhizoma Corydalis 13g, Rhizoma Atractylodis Macrocephalae 13g, Bulbus Allii Cepae 75g, Rhizoma Curcumae Longae 10g.

A kind of for decoction medicine treating gastric cancer and preparation method thereof, it is characterised in that described method includes walking as follows Suddenly it is prepared from:

A, above-mentioned raw materials Chinese medicine is picked decontamination and dust after, be respectively crushed into coarse according to mass parts ratio and decoct a drug wrapped；

B, the raw material Chinese medicine wrapped is put in cold boiled water soak one hour, the most again by soaked medicine and soak medicine Marmite put in the lump by the clear liquor of thing, and the cold boiled water injecting medicine 38mm carries out decocting 50 minutes for the first time, after leaching medicinal liquid, The tepor boiled water re-injecting medicine 33mm carries out decocting 40 minutes for the second time, and secondary mixing is condensed into the herb liquid 1080 of 50% Milliliter, standby after packed sealing.

A kind of for decoction medicine treating gastric cancer and preparation method thereof, it is characterised in that described instructions of taking is: will system The herb liquid got ready divides two days to be taken, and the morning, noon and afternoon service once, dosage 180 milliliter/time, within 30 days, are a course for the treatment of, serve on 8 After the course for the treatment of, symptom is improved, and tumor tumor body reduces more than 10%.

Each raw material Chinese medicine in prescription of the present invention all has detailed note in Chinese Pharmacopoeia, China's dictionary and China's book on Chinese herbal medicine Carry.The present invention selects most common of which Chinese medicine to be raw material, gives full play to the pharmacological effect of each component:

Radix Notoginseng, nature and flavor: sweet micro-hardship, temperature, there is effect of hemostasis, dissipating blood stasis, detumescence, analgesic therapy, be used for treating haematemesis, hemoptysis, epistaxis, Have blood in stool, dysentery, metrorrhagia, hundred abdominal masss, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain；

Herba Solani Lyrati, nature and flavor: cold in nature, sweet in the mouth, slightly poisonous, there is effect of heat-clearing and toxic substances removing, expelling wind and removing dampness, blood stasis dispelling, be used for treating damp and hot Jaundice, headache due to pathogenic wind-heat, leukorrhagia, rheumatic arthritis；

Fructus Arctii, nature and flavor: acrid in the mouth, hardship, cold in nature, there is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling, use In diseases such as treatment cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule impermeable, rubella pruritus, sore swollen toxins；

Herba Agrimoniae, nature and flavor: bitter in the mouth, puckery, property are put down, and have effect of astringing to arrest bleeding, dysentery relieving, parasite killing, be used for treating spitting of blood, haematemesis, Hematuria, have blood in stool, dysentery, bleeding not during menses, impairment caused by overstrain take off power, carbuncle, traumatic injury, wound hemorrhage；

Radix Achyranthis Bidentatae, nature and flavor: bitter, acid, property are put down, have invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, draw that enemy state (fiery) is descending, inducing diuresis for treating stranguria syndrome it Effect, be used for treating soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, abdominal pain due to blood stasis in puerperal, note of the ancient Chinese abdominal mass, retention of placenta, pyretic stranguria, Stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain；

Pseudobulbus Cremastrae Seu Pleiones, nature and flavor: sweet in the mouth, micro-pungent, cold in nature, mild toxicity, there is effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, antitumor, be used for controlling Treat carbuncle malignant boil, scrofula tuberculosis, pharyngalgia sore throat, Serpentis, insect bite wound；

The Rhizoma Pinelliae, nature and flavor: acrid in the mouth, warm in nature, poisonous, there is effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, cough for treatment Breathe heavily the diseases such as abundant expectoration, vomiting regurgitation, feeling of oppression and fullness in the chest and epigastrium headache dizziness, uneasy sleeping at night, gall subcutaneous nodule, swollen ulcer drug；

Rhizoma Sparganii, nature and flavor: pungent, bitter, flat, there is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving, be used for treating lump in the abdomen mass in the abdomen, blood stasis amenorrhea, Food stagnation distending pain；

Herba Hedyotidis Diffusae, nature and flavor, hardship are sweet, cold, nontoxic, have effect of heat-clearing and toxic substances removing, dampness removing, are used for treating heat-clearing and toxic substances removing, profit Wet disease such as grade；

Herba Scutellariae Barbatae, nature and flavor: acrid in the mouth, hardship, cold in nature, there is heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, effect of inducing diuresis to remove edema, be used for treating heat Poison carbuncle, have sore throat, lung abscess, acute appendicitis, scrofula, venom, traumatic injury, haematemesis, epistaxis, stranguria with blood, edema, ascites and cancer The diseases such as disease；

Radix Asparagi, nature and flavor: sweet, bitter, cold, there is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, be used for treating dryness of the lung dry cough, asthenia is coughed Cough, the insomnia thirsty, vexed of Tianjin wound, interior-heat are quenched one's thirst, dryness of the intestine constipation, diphtheria, the gesture anticancer, clear that relieves internal heat reduces phlegm, nourshing Yin and drynsessmoistening prescription；

Radix Ophiopogonis, nature and flavor: hardship sweet, micro-, cold, there is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire, be used for treating the dryness of the lung and do Cough, lung abscess, deficiency of YIN chronic cough, Tianjin wound are thirsty, quench one's thirst, vexed insomnia, have sore throat, dryness of the intestine constipation, heat in blood tell the diseases such as nosebleed；

Flos Sophorae, nature and flavor: bitter in the mouth, cold nature, there is effect of cooling blood for hemostasis, liver heat removing and eyesight improving, be used for treating under discharging fresh blood stool, hemorrhoid Blood, dysentery, hematuria, stranguria with blood, metrorrhagia, haematemesis, epistaxis, liver-heat headache, conjunctival congestion and swelling pain, carbuncle skin infection；

Radix Sophorae Tonkinensis, nature and flavor: bitter, cold, poisonous, there is heat-clearing and toxic substances removing, effect of detumescence sore-throat relieving, be used for treating fire-toxin pent up, throat Swell and ache, gingivitis；

Rhizoma Corydalis, nature and flavor: acrid, bitter, warm, nontoxic, have invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, effect of pain relieving, be used for treating trusted subordinate's waist knee joint All pains, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury；

The Rhizoma Atractylodis Macrocephalae, nature and flavor: bitter in the mouth, sweet, warm in nature, there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, be used for treating temper The few abdominal distention of weakness, spiritlessness and weakness, lack of appetite, big loose stool are thin, fluid-retention stagnating in the interior, dysuria, edema, dizziness due to fluid-retention, temperature numbness are ached, gas The empty disease such as spontaneous perspiration, frequent fetal movement；

Bulbus Allii Cepae, nature and flavor: warm in nature, Xin Gan, there is intestine moistening, regulating qi-flowing for harmonizing stomach, spleen invigorating feed, effect of dispersing wind-cold, be used for treating sugar The urine disease such as disease, obesity, dyspepsia, hypertension, hyperlipidemia, arteriosclerosis, wind and cold are lossless, nasal obstruction, indigestion and loss of appetite, the dyspepsia of food stagnation；

Rhizoma Curcumae Longae, nature and flavor: bitter in the mouth, pungent, warm in nature, there is effect of removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia, be used for treating all cards of stagnation of QI and blood, Born of the same parents' abdomen hypochondriac pain, dysmenorrhes, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, rheumatic arthralgia, traumatic injury, carbuncle.

Medicine of the present invention is differential diagnosis of diseases based on Chinese traditional treatment gastric cancer and the dialectical principle combined, from pharmacological action and effect Mechanism is thought: with regard to gastric cancer one disease, each raw material herbal medicine efficacy in medicine provided by the present invention is played altogether, has above-mentioned disease very well Therapeutic effect.

Detailed description of the invention

The present invention is aiming at the treatment of above-mentioned gastric cancer and a kind of Chinese medicine formula of proposing, uses medicine prepared by this formula Good drug efficacy, instant effect, it is the Chinese prescription of a treating both the principal and secondary aspects of a disease, is particularly suitable for Clinical practice.Concrete below in conjunction with the present invention Embodiment is described in further detail:

Embodiment 1:

A kind of decoction medicine for treating gastric cancer, it is characterised in that each component of described medicine and mass parts ratio thereof are as follows Shown in:

Radix Notoginseng 12g, Herba Solani Lyrati 35g, Fructus Arctii 10g, Herba Agrimoniae 13g, Radix Achyranthis Bidentatae 12g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Pinelliae 7g, Rhizoma Sparganii 8g, Agkistrodon SHECAO 25g, Herba Scutellariae Barbatae 25g, Radix Asparagi 12g, 13g Flos Sophorae 10g Radix Ophiopogonis, Radix Sophorae Tonkinensis 5g, Rhizoma Corydalis 13g, Rhizoma Atractylodis Macrocephalae 13g, Bulbus Allii Cepae 75g, Rhizoma Curcumae Longae 10g.

Embodiment 2:

A kind of decoction medicine for treating gastric cancer, it is characterised in that each component of described medicine and mass parts ratio thereof are as follows Shown in:

Radix Notoginseng 13g, Herba Solani Lyrati 40g, Fructus Arctii 11g, Herba Agrimoniae 16g, Radix Achyranthis Bidentatae 13g, Pseudobulbus Cremastrae Seu Pleiones 5.5g, Rhizoma Pinelliae 8g, Rhizoma Sparganii 9g, spend in vain Herba Hedyotidis Diffusae 28g, Herba Scutellariae Barbatae 26g, Radix Asparagi 13g, 14g Flos Sophorae 11g Radix Ophiopogonis, Radix Sophorae Tonkinensis 5.5g, Rhizoma Corydalis 14g, Rhizoma Atractylodis Macrocephalae 14g, Bulbus Allii Cepae 85g, Rhizoma Curcumae Longae 11g.

Embodiment 3:

A kind of decoction medicine for treating gastric cancer, it is characterised in that each component of described medicine and mass parts ratio thereof are as follows Shown in:

Radix Notoginseng 16g, Herba Solani Lyrati 48g, Fructus Arctii 12g, Herba Agrimoniae 18g, Radix Achyranthis Bidentatae 16g, Pseudobulbus Cremastrae Seu Pleiones 6g, Rhizoma Pinelliae 9g, Rhizoma Sparganii 10g, spend in vain Herba Hedyotidis Diffusae 32g, Herba Scutellariae Barbatae 30g, Radix Asparagi 15g, 16g Flos Sophorae 12g Radix Ophiopogonis, Radix Sophorae Tonkinensis 6g, Rhizoma Corydalis 16g, Rhizoma Atractylodis Macrocephalae 16g, Bulbus Allii Cepae 100g, Rhizoma Curcumae Longae 12g.

Model case

Through clinical conditions patients with gastric cancer totally 306 example, the age is 173 examples of more than 58 years old, and only 133 examples are less than 58 years old. 215 examples that in 306 example patients, symptom is improved, 91 effective examples, total effective rate reaches 100%.

Claims (3)

1. the decoction medicine being used for treating gastric cancer, it is characterised in that each component of described medicine and mass parts thereof are such as Shown in lower:

Radix Notoginseng 8～16g, Herba Solani Lyrati 25～48g, Fructus Arctii 5～12g, Herba Agrimoniae 10～18g, Radix Achyranthis Bidentatae 5～16g, Pseudobulbus Cremastrae Seu Pleiones 3～6g, The Rhizoma Pinelliae 3～9g, Rhizoma Sparganii 5～10g, Herba Hedyotidis Diffusae 15～32g, Herba Scutellariae Barbatae 15～30g, Radix Asparagi 6～15g, Chinese scholartree Radix Ophiopogonis 6～16g Spend 5～12g, Radix Sophorae Tonkinensis 3～6g, Rhizoma Corydalis 8～16g, the Rhizoma Atractylodis Macrocephalae 3～16g, Bulbus Allii Cepae 50～100g, Rhizoma Curcumae Longae 3～12g.

Decoction medicine for treating gastric cancer the most according to claim 1, it is characterised in that each component of described medicine And mass parts ratio is as follows:

Radix Notoginseng 10～13g, Herba Solani Lyrati 30～40g, Fructus Arctii 7～11g, Herba Agrimoniae 12～16g, Radix Achyranthis Bidentatae 10～13g, Pseudobulbus Cremastrae Seu Pleiones 4～ 5.5g, the Rhizoma Pinelliae 6～8g, Rhizoma Sparganii 7～9g, Herba Hedyotidis Diffusae 18～28g, Herba Scutellariae Barbatae 18～26g, Radix Asparagi 10～13g, Radix Ophiopogonis 10～ 14g Flos Sophorae 7～11g, Radix Sophorae Tonkinensis 4～5.5g, Rhizoma Corydalis 10～14g, the Rhizoma Atractylodis Macrocephalae 10～14g, Bulbus Allii Cepae 60～85g, Rhizoma Curcumae Longae 8～ 11g。

3. according to described in claim 1 to 2 for treating the decoction medicine of gastric cancer, it is characterised in that each of described medicine Component and mass parts ratio thereof are as follows:

Radix Notoginseng 12g, Herba Solani Lyrati 35g, Fructus Arctii 10g, Herba Agrimoniae 13g, Radix Achyranthis Bidentatae 12g, Pseudobulbus Cremastrae Seu Pleiones 5g, Rhizoma Pinelliae 7g, Rhizoma Sparganii 8g, Agkistrodon SHECAO 25g, Herba Scutellariae Barbatae 25g, Radix Asparagi 12g, 13g Flos Sophorae 10g Radix Ophiopogonis, Radix Sophorae Tonkinensis 5g, Rhizoma Corydalis 13g, Rhizoma Atractylodis Macrocephalae 13g, Bulbus Allii Cepae 75g, Rhizoma Curcumae Longae 10g.