CN106236326B - Big stage Bone Defect Repari system - Google Patents
Big stage Bone Defect Repari system Download PDFInfo
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- CN106236326B CN106236326B CN201610740383.5A CN201610740383A CN106236326B CN 106236326 B CN106236326 B CN 106236326B CN 201610740383 A CN201610740383 A CN 201610740383A CN 106236326 B CN106236326 B CN 106236326B
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- bone defect
- defect repari
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30576—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs
- A61F2002/30578—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs having apertures, e.g. for receiving fixation screws
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Materials For Medical Uses (AREA)
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Abstract
The present invention provides a kind of big stage Bone Defect Repari system,Including braced frame and bone renovating material,It is provided with grid on the support frame,It is equipped with convex body in the outside of braced frame,Convex body is equipped with the first screw hole,It is connected with screw on the first screw hole,It is provided with the second screw hole on each apex angle of grid,Bone renovating material is stereochemical structure identical with the shape of grid,The inlay element to match with grid is equipped at the upper a quarter of bone renovating material vertical height,Bone renovating material is connect by inlay element with grid activity,Utilize the Bone Defect Repari system of braced frame and bone renovating material mosaic mode,Flexible structure is changeable,Suitable for clinical manipulation,First screw hole and the second screw hole are set simultaneously,At any time fixed position is provided for the Bone Defect Repari system of different structure,Simultaneously support frame,Convex body and screw are all made of the material that can be degraded by human body,It avoids in its long-term existence human body and generates adverse reaction,Even there is the danger infected.
Description
Technical field
The invention belongs to Bone Defect Repari fields, more particularly, to a kind of big stage Bone Defect Repari system.
Background technology
The reparation of bulk bone defect and reconstruction one caused by congenital osteopathy, wound, infection or tumour resected bone etc.
It is directly the problem and research hotspot of field of orthopaedics.Although traditional autologous bone transplanting skeletonization effect is good, bone resource is less, it is difficult to
The bone defect of larger area is repaired, and complicated for operation, allogenic bone transplantation, artificial substituent's displacement, Limb lengthening Transfer have all existed
Clinically applied, but all had some limitations, for example, due to titanium alloy web plate have good biocompatibility,
The advantages that non-toxic and high intensity, is widely used in the clinical application to skull reparation, but in human body due to titanium alloy
It can not be degraded, patient often has heavier sense of insecurity, especially for the patient of big stage bone defect, large area titanium alloy
Constriction can make patient cause headache, it is dizzy, be afraid of vibration and to syndromes such as the rejections of titanium alloy, overlong time may
The problems such as causing infection；For the big stage bone defect of four limbs, allogenic bone transplantation reparation is often applied, is equally also faced with because of skin
The less new bone of matter bone void substitutes slow, it is extremely difficult to the problems such as completing skeletonization.In addition, for the situation is critical, needs to carry out immediately
For the patient of Bone Defect Repari, due to cannot produce in time with repair system that bone defect position shape matches and miss best
Treatment time.
Invention content
The problem to be solved in the present invention is to provide a kind of big stage Bone Defect Repari system light, degradable, structure is changeable.
In order to solve the above technical problems, the technical solution adopted by the present invention is：Big stage Bone Defect Repari system, including support frame
Frame and bone renovating material are provided with grid in the braced frame, convex body are equipped in the outside of the braced frame, described
Convex body is equipped with the first screw hole, and activity chain is connected to screw on first screw hole, is set on each apex angle of the grid
It is equipped with the second screw hole, the bone renovating material is stereochemical structure identical with the shape of the grid, in the Bone Defect Repari material
It is equipped with the inlay element to match with the grid at the upper a quarter in material vertical height direction, the bone renovating material passes through
The inlay element is connect with the grid activity.
Further, the material of the braced frame, convex body and screw is polyactide copolymer or blend and magnesium salts
Compound.
Further, the material of the braced frame, convex body and screw is magnesium or magnesium base alloy.
Further, the ingredient of the bone renovating material is mainly collagen, calcium salt and growth factor.
Further, the structure of the braced frame can be planar as, tubulose or irregular polyhedrons.
Further, the shape of the grid is circle, triangle, quadrangle, pentagon or hexagon.
Further, it is preferable to, the shape of the grid is quadrangle or hexagon.
Further, further include porous insulation film, the porous insulation film is covered in the outer surface of the bone renovating material.
Further, the thickness of the porous insulation film is in 0.3mm-2mm, and aperture is in 5um-100um.
Further, the diameter of the inlay element is less than the diameter of the bone renovating material.
Further, first screw hole and second screw hole are equal in magnitude.
Compared with prior art, the present invention has the advantage that is with advantageous effect：1, braced frame and Bone Defect Repari material are utilized
Expect the Bone Defect Repari system of mosaic mode, flexible structure is changeable, can cope with many emergencies, saves Production Time, simultaneously
First screw hole and the second screw hole are set, provide fixed position at any time for the Bone Defect Repari system of different structure, it is convenient, fast；
2, braced frame, convex body and screw be all made of the high molecular material of polyactide copolymer or blend and the compound of magnesium salts or
The metal material of magnesium, magnesium base alloy, these materials human body memory over time, can be degraded automatically by human body, avoid
Bad foreign body reaction is generated in long-term existence human body, or even the danger that stress shielding causes fracture occurs.
Description of the drawings
Fig. 1 is the mosaic texture schematic diagram of big stage Bone Defect Repari system of the invention.
Fig. 2 is the bone renovating material structural schematic diagram of big stage Bone Defect Repari system of the invention.
Fig. 3 is the tubular support framework structural schematic diagram of big stage Bone Defect Repari system of the invention.
Fig. 4 is the structural representation of the braced frame with square grids structures of big stage Bone Defect Repari system of the invention
Figure.
In figure：1- braced frames；2- bone renovating materials；3- grids；4- convex bodys；The first screw holes of 5-；The second screw holes of 6-；
7- inlay elements.
Specific implementation mode
It elaborates below in conjunction with the accompanying drawings to the specific implementation mode of the present invention.
As shown in Figure 1 and Figure 2, big stage Bone Defect Repari system, including braced frame 1 and bone renovating material 2, in the support
It is provided with grid 3 on frame 1, is equipped with convex body 4 in the outside of the braced frame 1, the first screw hole is equipped on the convex body 4
5, activity chain is connected to screw (not shown) on first screw hole 5, and the second spiral shell is provided on each apex angle of the grid 3
Nail hole 6, the bone renovating material 2 are stereochemical structures identical with the shape of the grid 3, are being parallel to the bone renovating material
The surface of 2 central axes is equipped with the inlay element 7 to match with the grid 3, and the bone renovating material 2 inlays list by described
Member 7 is flexibly connected with the grid 3, and the big stage Bone Defect Repari system of this structure is repaiied using the supporting role and bone of braced frame 1
The effect of the promotion osteanagenesis of multiple material 2 is combined, and active link is carried out by way of inlaying, in each of each grid 3
A apex angle is both provided with the second screw hole 6, in case of emergency can be according to the shape of patient bone defect, to support
Frame 1 is trimmed, and the screw can be fixed it by any one the second screw hole 6, and this structure is changeable
Bone Defect Repari system can play a great role when coping with emergency, reduce the time for making repair system, and support
The material of frame 1, convex body 4 and screw is that the compound of polyactide copolymer or blend and magnesium salts or magnesium, magnesium-based are closed
Gold, when material is polyactide copolymer or blend, molecular weight be more than 20KDa, magnesium salts be magnesium carbonate or magnesium phosphate, these
Material can play the role of good mechanical support, and can be degraded by human body, and not injured to human body；And bone is repaiied
It is collagen, calcium salt and growth factor, wherein glue that multiple material 2, which has the ability for promoting osteanagenesis well, its main component,
Former albumen is I types and/or type III collagen, and calcium salt is hydroxyapatite or calcium phosphate, and the growth factor is Nell-1 eggs
In vain, can there are allogeneic demineralized bone matrix, xenogenesis demineralized bone matrix, collagen etc. as the substance of bone renovating material.
Shown in as shown in Figure 1, Figure 3 and Figure 4, the structure of the braced frame 1 can be planar as, tubulose or irregular multi-panel
Body, the braced frame 1 of different structure can meet the reparation of the bone defect of different parts, and flat braced frame can meet cranium
The reparation of jawbone defect, and tubular support framework can meet the reparation of the bone defects such as four limbs, meanwhile, braced frame 1 can be with
Be single layer can also be multilayer, in braced frame 1 shape of grid 3 is circle, triangle, square, pentagon or six
The mesh shape of side shape various structures corresponds to the inlay element 7 of corresponding construction, to meet bone defect position of different shapes,
In, it is preferred that the shape of the grid 3 is quadrangle or hexagon.
Further, further include porous insulation film (not shown), the porous insulation film is covered in the bone renovating material 2
Outer surface, the thickness of the porous insulation film is in 0.3mm-2mm, and aperture is in 5um-100um, the main function of porous insulation film
It is that soft tissue is isolated with bone tissue, prevents from occupying the growth position of bone tissue since soft tissue growth is too fast, in addition,
Porous insulation film is by collagen or collagen and polysaccharide or collagen, polysaccharide and calcium salt Material cladding, wherein glue
Former albumen is I-type collagen, and polysaccharide is chitosan, hyaluronic acid, chondroitin sulfate etc., and calcium salt is hydroxyapatite or phosphoric acid
Calcium, therefore, porous insulation film can also be degraded by human body.
Further, the diameter of the inlay element 7 is less than the diameter of the bone renovating material 2, in order to make inlay element 7
It can be good at being fixed on the grid 3 so that bone renovating material 2 is maximum to play the effect for promoting bone uptake.
Further, first screw hole 5 and 6 hole of the second screw are equal in magnitude, are repaired to bone defect
It in the process, can quickly will be in the first screw hole 5 when needing to modify to braced frame 1 to meet bone defect position
Screw is applied in the second screw hole 6, convenient, fast, the saving time.
It is embedded in the grid 3 in braced frame 1 using the inlay element 7 on bone renovating material 2, produces and suffer from
The big stage Bone Defect Repari system that person's wound area is consistent, is fixed it using the screw on convex body 4, in emergency and
In the case of there is no suitable Bone Defect Repari system, need to modify to it because on each apex angle of grid 3 all there are
Second screw hole 6, therefore modified Bone Defect Repari system screw can be fixed by the second screw hole 6, while being repaiied in bone
The outer surface of multiple material 2 covers porous insulation film, achievees the purpose that soft tissue and bone tissue is isolated, through repairing after a period of time
It is multiple, under the facilitation of bone renovating material 2, the osteanagenesis of patient trauma position, wound healing, the braced frame 1 of patient's body,
Convex body 4, screw and porous insulation film can decompose disappearance in human body, and will not be damaged to human body.
One embodiment of the present invention has been described in detail above, but the content be only the present invention preferable implementation
Example should not be construed as limiting the practical range of the present invention.It is all according to all the changes and improvements made by the present patent application range
Deng should all still fall within the scope of the patent of the present invention.
Claims (11)
1. big stage Bone Defect Repari system, it is characterised in that：Including braced frame (1) and bone renovating material (2), in the support frame
It is provided with grid (3) on frame (1), is equipped with convex body (4) in the outside of the braced frame (1), the is equipped on the convex body (4)
One screw hole (5) is connected with screw on first screw hole (5), and is provided on each apex angle of the grid
Two screw holes (6), the bone renovating material (2) is stereochemical structure identical with the shape of the grid (3), in the Bone Defect Repari
The inlay element (7) to match with the grid (3), the Bone Defect Repari are equipped at the upper a quarter of material (2) vertical height
Material (2) is flexibly connected by the inlay element (7) with the grid (3).
2. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The braced frame (1), convex body (4)
Material with screw is the compound of polyactide copolymer or blend and magnesium salts.
3. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The braced frame (1), convex body (4)
Material with screw is magnesium or magnesium base alloy.
4. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The ingredient of the bone renovating material (2)
Predominantly collagen, calcium salt and growth factor.
5. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The structure of the braced frame (1) is
Flat, tubulose or irregular polyhedrons.
6. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The shape of the grid (3) be it is round,
Triangle, quadrangle, pentagon or hexagon.
7. big stage Bone Defect Repari system according to claim 1 or 6, it is characterised in that：Preferably, the grid (3)
Shape is quadrangle or hexagon.
8. big stage Bone Defect Repari system according to claim 1, it is characterised in that：Further include porous insulation film, it is described more
Hole Obstruct membrane is covered in the outer surface of the bone renovating material (2).
9. big stage Bone Defect Repari system according to claim 8, it is characterised in that：The thickness of the porous insulation film exists
0.3mm-2mm, aperture is in 5um-100um.
10. big stage Bone Defect Repari system according to claim 1, it is characterised in that：The diameter of the inlay element (7) is small
Diameter in the bone renovating material (2).
11. big stage Bone Defect Repari system according to claim 1, it is characterised in that：First screw hole (5) with it is described
Second screw hole (6) is equal in magnitude.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610740383.5A CN106236326B (en) | 2016-08-26 | 2016-08-26 | Big stage Bone Defect Repari system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610740383.5A CN106236326B (en) | 2016-08-26 | 2016-08-26 | Big stage Bone Defect Repari system |
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| CN106236326A CN106236326A (en) | 2016-12-21 |
| CN106236326B true CN106236326B (en) | 2018-08-10 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106923934B (en) * | 2017-03-14 | 2019-06-04 | 北京爱康宜诚医疗器材有限公司 | Titanium net is used in orthopaedics implantation |
| CN108451627B (en) * | 2018-04-04 | 2023-11-17 | 中国人民解放军总医院 | Bone repair material blending device |
| CN110384571A (en) * | 2019-08-20 | 2019-10-29 | 广东省新材料研究所 | A kind of large segmental bone defect implantation material and preparation method thereof |
| CN113171489A (en) * | 2020-11-09 | 2021-07-27 | 北京大学 | Novel transparent brain bone replacement device and preparation method thereof |
| US11957589B2 (en) * | 2021-08-27 | 2024-04-16 | Acumed Llc | Non-patient-specific craniofacial implants for correcting and/or preventing temporal or pterional deformities |
| CN115154654A (en) * | 2022-06-28 | 2022-10-11 | 广东健齿生物科技有限公司 | Oral bone tissue repair system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN206214236U (en) * | 2016-08-26 | 2017-06-06 | 天津市赛宁生物工程技术有限公司 | A kind of megastage Bone Defect Repari device |
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| CN101474430B (en) * | 2009-01-13 | 2013-01-09 | 武汉大学 | Tissue regeneration membrane with bioactivity and preparation method thereof |
| CN102883685B (en) * | 2010-03-10 | 2015-07-22 | 奥斯-Q公司 | Implants and methods for correcting tissue defects |
| CN101785715A (en) * | 2010-03-12 | 2010-07-28 | 张纯朴 | Auxiliary bone grafting bracket for large bone defect |
| EP2598029B1 (en) * | 2010-07-30 | 2016-04-06 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Cranial implant assembly adapted for insertion during craniectomy procedure |
| US9463046B2 (en) * | 2011-08-22 | 2016-10-11 | Ossdsign Ab | Implants and methods for using such implants to fill holes in bone tissue |
| CN102512267A (en) * | 2011-12-07 | 2012-06-27 | 上海交通大学 | Bone restoration body with composite porous structure and preparation method thereof |
| AU2013358613B9 (en) * | 2012-12-14 | 2017-11-02 | Ossdsign Ab | Cement-forming compositions, monetite cements, implants and methods for correcting bone defects |
| US10076416B2 (en) * | 2013-02-12 | 2018-09-18 | Ossdsign Ab | Mosaic implants, kits and methods for correcting bone defects |
| AU2015302923B2 (en) * | 2014-08-14 | 2020-05-14 | Ossdsign Ab | Bone implants for correcting bone defects |
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| CN206214236U (en) * | 2016-08-26 | 2017-06-06 | 天津市赛宁生物工程技术有限公司 | A kind of megastage Bone Defect Repari device |
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