CN208864880U - A kind of assembly type cellular bone tissue engineering scaffold - Google Patents
A kind of assembly type cellular bone tissue engineering scaffold Download PDFInfo
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- CN208864880U CN208864880U CN201721433153.0U CN201721433153U CN208864880U CN 208864880 U CN208864880 U CN 208864880U CN 201721433153 U CN201721433153 U CN 201721433153U CN 208864880 U CN208864880 U CN 208864880U
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- bone tissue
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- tissue engineering
- bone
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Abstract
The utility model discloses a kind of assembly type cellular bone tissue engineering scaffolds, its composition is: more than two points of shells (1) inlay the rack shell for constituting closure, and it is all divide shell (1) to be made of pure titanium, divide on the wall of shell (1) and be provided with through slot (2) or through-hole；The inner cavity of the rack shell is placed with biomaterial block and/or particles of bioglass with Bone Defect Repari effect.This kind of bone tissue engineering scaffold has good mechanical property, can preferably bear to repair the pressure in site, avoid damage of the operation external force to bracket；The growth for having good biocompatibility again simultaneously, capable of advantageously promoting bone, improves the quality of Bone Defect Repari.
Description
Technical field
The utility model relates to a kind of bone tissue engineering scaffolds, and in particular to a kind of assembly type cellular bone tissue engineer branch
Frame.
Background technique
Bone tissue is by the synthesis of cell, organic substrate and inorganic matrix, and organic substrate provides elasticity, nothing for bone tissue
Machine base portion then provides mechanical strength for bone tissue.It, can be by being implanted into bone tissue work when the bone tissue of human body is damaged
Engineering support carries out structural reparation to bone tissue.The bone tissue engineering scaffold of implantation needs to have biocompatibility, to be conducive to
Cell ensures the deposition of cytoplasmic matrix in the adherency on its surface, proliferation and differentiation；Bone tissue engineering scaffold needs to have simultaneously
Standby porous, perforation characteristic, in favor of cell migration, be simultaneously also the conveying of nutriment and cell metabolism waste
Discharge provides necessary channel, and provides space for the formation of bone tissue and the growth of blood vessel.Bone tissue engineering scaffold also needs
There is enough rigidity that can bear to repair pressure brought by the surrounding tissue of site, while being also avoided that surgical procedure external force to branch
The damage of frame.
Existing tissue scaffold design is made of single bioceramic, medical high polymer or medical metal material.Biology pottery
There is tissue scaffold design made of ceramic material unique porous structure can simulate bone tissue and stable chemical performance, have one
Fixed osteoconductive and it is corrosion-resistant the advantages that.But its composition material is entirely bioceramic, and mechanical strength is not high, is only used for strong
Spend the reparation of lower bone defect.Medical macromolecular materials have certain biocompatibility, degradability, easy processing and source
Extensive advantage, but its composition material is entirely single medical macromolecular materials, there is also mechanical strength is low and degradation speed
Too fast problem, application are also limited.Tissue scaffold design made of medical metal material, mechanical strength are high；It is desirable
Bear the preferred bracket of the bone of high load, Chi Deng sclerous tissues and interventional therapy；But its composition material is entirely single medical
Metal material does not have bioactivity, and tunica fibrosa easy to form, the interface between bracket and tissue are long between tissue after implantation
Phase exists, and bracket is easy loose or dislocation.
Utility model content
The purpose of the utility model is to provide a kind of assembly type bone tissue engineering scaffold, this kind of bone tissue engineering scaffold has
Good mechanical property can preferably bear to repair the pressure in site, avoid damage of the operation external force to bracket；Have again simultaneously
Good biocompatibility, the growth that can advantageously promote bone, improve the quality of Bone Defect Repari.
The utility model realizes its goal of the invention the technical scheme adopted is that a kind of assembly type cellular bone tissue engineer
Bracket, composition is: more than two points of shells inlay the rack shell for constituting closure, and it is all divide shell to be made of pure titanium,
Divide on the wall of shell and is provided with through slot or through-hole；The inner cavity of the rack shell is placed with the biomaterial with Bone Defect Repari effect
Block and/or particles of bioglass.
Compared with prior art, the utility model has the beneficial effects that
One, the assembly type bone tissue engineering scaffold of the utility model, the rack shell pure titanium metal good by mechanical property
It is made.Therefore the mechanical property of entire bracket is good, during the entire process of Bone Defect Repari, can bear to repair site surrounding tissue well
Brought pressure；Meanwhile being also avoided that damage of the external force to bracket in surgical procedure, it prevents from bringing graft failure to sufferer
Injury.
Also, it is provided with through-hole or through slot on the shell wall of the bracket of the utility model, forms perforation on bracket shell
Porous structure is conducive to the migration of cell and provides space for the formation of bone tissue and the growth of blood vessel, can meet bone group comprehensively
Knit the requirement of reparation.
Two, the bone tissue engineering scaffold of the utility model, filled with Bone Defect Repari effect in the inner cavity of rack shell
Biomaterial.The mechanical property of biomaterial is poor but it is filled in bracket and does not have to bear external force, the mechanical property of bracket entirety
It can be unaffected；And the biomaterial of lumen loading can be by circulatory mediator through the through-hole or through slot on rack shell, effect
In the tissue for repairing position；To promote the growth of bone well, reduces the time of Bone Defect Repari, improves the quality of Bone Defect Repari.
Three, the assembly type bone tissue engineering scaffold of the utility model, shell are to be inlayed to constitute by more than two points of shells
Closed shape.Both shell simply and easily can be formed by dividing shell to inlay, the intracavity space being closed with addition, receiving, is determined
Position bulk or granular bone reparing biological material；Meanwhile and energy is easy to disassemble, loads or replace different biomaterials；
And allow bracket repeatedly, reuse.
Further, the biomaterial block with Bone Defect Repari effect of the utility model is hydroxy-apatite stone, collagen block, shell
One of glycan block, polylactic acid block, polyglycolic acid block, polycaprolactone block are a variety of.
Further, the particles of bioglass with Bone Defect Repari effect of the utility model is hydroapatite particles, collagen
One of particle, chitosan particle, particles of polylactic acid, polyglycolic acid particle, polycaprolactone particle are a variety of.
Hydroxyapatite and collagen are the main components of body bone tissue, and there is good biocompatibility and Bone Defect Repari to make
With the growth of bone tissue can be promoted；And chitosan, polylactic acid, polyglycolic acid, polycaprolactone are all from a wealth of sources, are easy to get
Biocompatibility is good, degradable high polymer material, has Bone Defect Repari effect, to the growth of bone tissue with good promotion
Effect.
The utility model is described in further detail with reference to the accompanying drawings and detailed description.
Detailed description of the invention
Fig. 1 is the schematic view of the front view of the utility model embodiment 1.
Fig. 2 is longitudinal schematic cross-sectional view of the utility model embodiment 1.
Fig. 3 is the overlooking structure diagram of the utility model embodiment 1.
Fig. 4 is the schematic view of the front view of the utility model embodiment 6.
Fig. 5 is longitudinal schematic cross-sectional view of the utility model embodiment 6.
Fig. 6 is the overlooking structure diagram of the utility model embodiment 6.
Specific embodiment
Embodiment 1
Fig. 1-3 is shown, and a kind of specific embodiment of the utility model is a kind of assembly type cellular bone tissue engineer branch
Frame, composition is: three points of shells 1 inlay the rack shell for constituting closure, and middle and upper part divides shell 1 to be point of shell of top cover, middle part
Shell 1 is body casing, and lower part divides shell 1 to be lower cover shell.And it is all divide shell 1 to be made of pure titanium, divide on the wall of shell 1 be provided with it is logical
Slot 2.The inner cavity of the rack shell is placed with hydroapatite particles.
Embodiment 2
The structure of this example and the structure of embodiment 1 are essentially identical, unique different to be simply that the interior of the rack shell
Hydroxy-apatite stone is placed in chamber.
Embodiment 3
The structure of this example and the structure of embodiment 1 are essentially identical, unique different to be simply that unique different be simply that
The through slot opened up on the wall of shell 1 is divided to be changed to through-hole, collagen particle and polylactic acid is placed in the inner cavity of the rack shell
The mixture of grain.
Embodiment 4
The structure of this example and the structure of embodiment 1 are essentially identical, unique different to be simply that the interior of the rack shell
Chitosan block is placed in chamber.
Embodiment 5
The structure of this example and the structure of embodiment 1 are essentially identical, unique different to be simply that the interior of the rack shell
Collagen block is placed in chamber.
Embodiment 6
Fig. 4-6 is shown, a kind of assembly type cellular bone tissue engineering scaffold of the utility model embodiment 6, and composition is:
Two points of shells 1 inlay the rack shell for constituting closure, two points of shells 1 be respectively on divide shell and lower point of shell.And all divide shell 1 equal
It is made of pure titanium, divides and be provided with through slot 2 on the wall of shell 1.The inner cavity of the rack shell is placed with polylactic acid block and polyethanol
The mixture of sour block.
Embodiment 7
The structure of this example and the structure of embodiment 6 are essentially identical, open up on unique different wall for being simply that point shell 1
Through slot is changed to through-hole, and chitosan particle is placed in the inner cavity of the rack shell.
Embodiment 8
The structure of this example and the structure of embodiment 6 are essentially identical, unique different to be simply that the interior of the rack shell
Polycaprolactone block is placed in chamber.
Embodiment 9
The structure of this example and the structure of embodiment 6 are essentially identical, unique different to be simply that the interior of the rack shell
Chitosan particle is placed in chamber.
Embodiment 10
The structure of this example and the structure of embodiment 6 are essentially identical, unique different to be simply that the interior of the rack shell
The mixture of polyglycolic acid particle and polycaprolactone particle is placed in chamber.
Claims (3)
1. a kind of assembly type cellular bone tissue engineering scaffold, it is characterized in that: more than two points of shells (1), which are inlayed, constitutes closure
Rack shell, and it is all divide shell (1) to be made of pure titanium, divide on the wall of shell (1) and be provided with through slot (2) or through-hole；Described
The inner cavity of rack shell is placed with biomaterial block and/or particles of bioglass with Bone Defect Repari effect.
2. a kind of assembly type cellular bone tissue engineering scaffold according to claim 1, which is characterized in that described has
The biomaterial block of Bone Defect Repari effect is hydroxy-apatite stone, collagen block, chitosan block, polylactic acid block, polyglycolic acid block, gathers oneself
One of lactone block is a variety of.
3. a kind of assembly type cellular bone tissue engineering scaffold according to claim 1, which is characterized in that described has
The particles of bioglass of Bone Defect Repari effect is hydroapatite particles, collagen particle, chitosan particle, particles of polylactic acid, poly- second
One of alcohol granulates, polycaprolactone particle are a variety of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721433153.0U CN208864880U (en) | 2017-11-01 | 2017-11-01 | A kind of assembly type cellular bone tissue engineering scaffold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721433153.0U CN208864880U (en) | 2017-11-01 | 2017-11-01 | A kind of assembly type cellular bone tissue engineering scaffold |
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| Publication Number | Publication Date |
|---|---|
| CN208864880U true CN208864880U (en) | 2019-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721433153.0U Expired - Fee Related CN208864880U (en) | 2017-11-01 | 2017-11-01 | A kind of assembly type cellular bone tissue engineering scaffold |
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| CN (1) | CN208864880U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802885A (en) * | 2017-11-01 | 2018-03-16 | 西南交通大学 | Assembly type bone tissue engineering scaffold |
| CN110680559A (en) * | 2019-09-27 | 2020-01-14 | 长沙晟天新材料有限公司 | Chest lock integrated piece and preparation method thereof |
-
2017
- 2017-11-01 CN CN201721433153.0U patent/CN208864880U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802885A (en) * | 2017-11-01 | 2018-03-16 | 西南交通大学 | Assembly type bone tissue engineering scaffold |
| CN110680559A (en) * | 2019-09-27 | 2020-01-14 | 长沙晟天新材料有限公司 | Chest lock integrated piece and preparation method thereof |
| CN110680559B (en) * | 2019-09-27 | 2022-02-15 | 长沙晟天新材料有限公司 | Chest lock integrated piece and preparation method thereof |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190517 Termination date: 20211101 |
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| CF01 | Termination of patent right due to non-payment of annual fee |