CN115154654A

CN115154654A - Oral bone tissue repair system

Info

Publication number: CN115154654A
Application number: CN202210747434.2A
Authority: CN
Inventors: 刘伟鸿; 党晓兵; 张春雨; 陈贤帅
Original assignee: Guangdong Jianchi Biotechnology Co ltd
Current assignee: Guangdong Jianchi Biotechnology Co ltd
Priority date: 2022-06-28
Filing date: 2022-06-28
Publication date: 2022-10-11

Abstract

The invention relates to the technical field of medical instruments and discloses an oral bone tissue repair system which comprises a mesh framework and a repair body coated on the mesh framework, wherein a biological shielding film is arranged on the surface of the repair body, and the mesh framework is made of magnesium alloy or pure magnesium. Compared with the prior art, the prosthesis which is prefabricated and formed shortens the operation time and can better fit the anatomical outline of the defect area; the absorbable magnesium alloy reticular framework provides a certain supporting effect for the structure, so that the structure can maintain a stable osteogenic space within a certain time; the net-shaped framework is an absorbable magnesium alloy, so that the net-shaped framework can be taken out without a secondary operation, and the pain of a patient is greatly reduced; the absorbable magnesium alloy mesh skeleton is embedded into the prosthesis, and the problems of possible membrane exposure and the like caused by abrasion and stimulation to mucous membranes and soft tissues do not exist.

Description

Oral bone tissue repair system

Technical Field

The invention relates to the technical field of medical instruments, in particular to an oral bone tissue repair system.

Background

Alveolar bone absorption atrophy caused by congenital tooth loss or tooth extraction and tooth loss is a common problem in oral medicine clinical treatment, and for alveolar bone severe bone defect patients, the bone mass is increased in the early stage by matching with horizontal or vertical bone augmentation surgery so as to meet the later-stage planting conditions. Guided Bone Regeneration (GBR) is one of the most widely used methods in Bone augmentation. Guided Bone Regeneration (GBR) is a technique of filling autologous bone, allogeneic bone, xenogeneic bone or a combination thereof in a bone defect area, and coating a biological barrier membrane on the surface to prevent the growth of fast-growing soft tissue cells, so that the soft tissue cells maintain a certain osteogenic space and ensure the growth of osteoblasts and blood vessels. The technical key points comprise two key factors influencing osteogenesis: barrier time and stability of the barrier film. The types of the bio-barrier membrane can be classified into an absorbable membrane and a non-absorbable membrane according to whether the bio-barrier membrane is degradable in vivo, wherein the absorbable membrane is usually a collagen membrane, etc., and the non-absorbable membrane is usually a titanium membrane, a polytetrafluoroethylene membrane, or a titanium reinforced polytetrafluoroethylene membrane, etc.

For the two methods, the absorbable membranes are used without secondary operation, but the absorbable membranes are high in price, poor in mechanical property, difficult to maintain stable osteogenic space and easy to influence the final osteogenic effect; the non-absorbable membrane can provide a sufficient barrier time for the growth of bone tissue, but is not decomposed in vivo, and still needs to be removed through secondary operation, and can also face the problems of difficult removal due to soft tissue adhesion and bone tissue ingrowth, and possible exposure of the titanium membrane due to the use of the titanium membrane.

Disclosure of Invention

In order to solve the above technical problems, an object of the present invention is to provide an oral bone tissue repair system, which combines the advantages of absorbable membranes and non-absorbable membranes, has good biocompatibility and high mechanical properties, is easily degraded and absorbed by human body, and does not need to be taken out after a secondary operation.

Based on the above, the invention provides a dental bone tissue repair system, which comprises a mesh framework capable of being absorbed by a human body and a repair body capable of being absorbed by the human body and coating the mesh framework, wherein the outer surface of the repair body is provided with a biological shielding film coating the repair body.

In some embodiments of the present application, the edge of the mesh-like skeleton is provided with a fixture hole, and a fixture nail is penetrated in the fixture hole.

In some embodiments of the present application, the number of the fixture holes is 1-3, and the fixture holes are penetrated with the fixture nails.

In some embodiments of the present application, the mesh skeleton has a thickness of 0.1 to 0.5mm.

In some embodiments of the present application, the mesh skeleton is made of an absorbable magnesium alloy.

In some embodiments of the present application, the prosthesis comprises 1% to 20% of animal-derived collagen in the composition.

The embodiment of the invention provides an oral bone tissue repair system, which has the following beneficial effects compared with the prior art:

the invention provides a system for repairing oral bone tissue, which comprises a reticular framework capable of being absorbed by a human body and a repairing body which coats the reticular framework and can also be absorbed by the human body, wherein an absorbable biological shielding film is covered on the surface of the repairing body. The mesh skeleton is made of magnesium alloy, the components of the restoration body comprise 1-20% of animal-derived collagen such as pig collagen, and the rest components are artificial bone restoration materials such as one or more of biological ceramics, calcium phosphate bone cement, hydroxyapatite, bioactive glass and the like. The animal-derived collagen enables the prosthesis to maintain a certain form and has a certain plasticity, and the artificial bone repair material has bone conduction and bone regeneration effects, can be completely degraded and absorbed, and has a certain osteogenesis inducing capacity. The prefabricated and formed prosthesis shortens the operation time and can better fit the anatomical contour of the defect area; the absorbable magnesium alloy reticular framework provides a certain supporting effect for the structure, so that the structure can maintain a stable osteogenic space within a certain time; the net-shaped framework is an absorbable magnesium alloy, and is taken out without secondary operation, so that the pain of a patient is greatly reduced; the absorbable magnesium alloy mesh skeleton is embedded into the prosthesis, and the problems of possible membrane exposure and the like caused by abrasion and stimulation to mucous membranes and soft tissues do not exist.

Drawings

FIG. 1 is a schematic structural view of an oral bone tissue repair system according to an embodiment of the present invention;

FIG. 2 is a schematic assembly view of an oral bone tissue repair system according to an embodiment of the present invention;

fig. 3 is a cross-sectional view of an oral bone tissue repair system in accordance with an embodiment of the present invention.

In the figure, 1, a net framework; 2. repairing the body; 3. a biological barrier membrane; 4. a fixture hole; 5. a retention bone nail; 6. an alveolar bone.

Detailed Description

The following detailed description of the present invention is provided in connection with the accompanying drawings and examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.

It should be understood that the terms "front", "rear", and the like are used herein to describe various information, but the information should not be limited to these terms, which are used only to distinguish one type of information from another. For example, "front" information may also be referred to as "rear" information, and "rear" information may also be referred to as "front" information without departing from the scope of the present invention.

As shown in fig. 1 to 3, an embodiment of the present invention provides a system for repairing a dental bone tissue, which includes a magnesium alloy mesh skeleton 1 and a prosthesis 2 coated on the mesh skeleton 1, wherein the prosthesis 2 is disposed on a surface of an alveolar bone 6 to be repaired, and a biological barrier film 3 coated on the prosthesis 2 is disposed on an outer surface of the prosthesis 2. Specifically, the components of the prosthesis 2 comprise 1% -20% of animal-derived collagen, such as porcine collagen, and the rest components are the existing artificial bone repair materials, such as biological ceramics, calcium phosphate bone cement, hydroxyapatite, bioactive glass and the like, and belong to the combination of one or more materials. The animal-derived collagen enables the prosthesis 2 to maintain a certain shape and have a certain plasticity, and the artificial bone repair material has bone conduction and bone regeneration effects, can be completely degraded and absorbed, and has a certain osteogenesis induction capability. The prosthesis 2 which is prefabricated and formed shortens the operation time and can better fit the anatomical contour of the defect area; the absorbable magnesium alloy reticular skeleton 1 provides a certain supporting effect for the structure, so that the structure can maintain a stable osteogenic space within a certain time; the reticular skeleton 1 is an absorbable magnesium alloy, and is taken out without a secondary operation, so that the pain of a patient is greatly reduced; the absorbable magnesium alloy mesh skeleton 1 is embedded in the prosthesis 2, and the problems of possible membrane exposure and the like caused by abrasion and stimulation to mucous membranes and soft tissues do not exist.

Further, for the prosthesis 2 of the present application, the shape thereof may be customized, i.e. fit to the defect shape of the alveolar bone 6, or may be matched, i.e. various types with different sizes are prepared for typical alveolar bone defect areas.

Further, in some embodiments of the present application, the mesh-like skeleton 1 is made of a magnesium alloy material or pure magnesium, the magnesium alloy material has a certain mechanical strength, and can support the prosthesis 2, and meanwhile, the magnesium alloy material can be absorbed and degraded by a human body, and does not need to be taken out through a secondary operation. Furthermore, the edge of the reticular framework 1 is provided with a fixture hole 4. Specifically, the reticular skeleton 1 is a reticular or porous curved surface structure, the overall cross-sectional shape of the reticular skeleton is in an inverted L shape, the turning part is in smooth transition through a round angle, the size of the pores is 0.5-7mm, and the shape of the pores can be triangular or polygonal, circular or irregular, and the like. The retention nail hole 4 is a circular ring sheet-shaped structure, is positioned at the edge of the reticular framework 1, is connected with the reticular framework 1 through a straight rod, avoids the tooth root of the adjacent tooth and the important anatomical structure at the setting position, and is matched with the diameter of the retention nail 5 by the inner diameter of the retention nail hole 4, wherein the range is between 0.5mm and 3 mm. Meanwhile, the number of the fixture holes 4 is determined according to the size of the defect, 1-3 fixture holes 4 are suitable for small and medium-sized bone defects such as two-wall or three-wall defects caused by single tooth loss, and 2-6 fixture holes 4 are arranged under the condition of severe alveolar ridge atrophy, particularly bone absorption of a plurality of continuous tooth positions.

Further, in some embodiments of the present application, the thickness of the magnesium alloy mesh skeleton 1 is 0.1-0.5mm, and the mesh skeleton 1 has a certain thickness to provide a certain supporting effect before being degraded, so as to maintain a stable osteogenic space. Meanwhile, the magnesium alloy reticular skeleton 1 has good biocompatibility with bone tissues, and the pain of patients is reduced.

As shown in the figure, the prosthesis 2 completely wraps the magnesium alloy reticular skeleton 1, the fixture holes 4 are tightly attached to the bone surface, and the fixture holes 4 are exposed to facilitate the placement of fixture nails 5. The shape contour of the prosthesis 2 is matched with the anatomical form of the alveolar bone, the surface is smooth and transitional without edges and corners, the stimulation to mucous membrane can be reduced, and the discomfort of a patient after operation can be reduced.

In summary, the invention provides a system for repairing an oral bone tissue, which comprises a mesh framework and a repairing body coated on the mesh framework, wherein a biological shielding film is arranged on the surface of the repairing body, and the mesh framework is made of magnesium alloy or pure magnesium. Compared with the prior art, the prosthesis which is prefabricated and formed shortens the operation time and can better fit the anatomical outline of the defect area; the absorbable magnesium alloy reticular framework provides a certain supporting effect for the structure, so that the structure can maintain a stable osteogenic space within a certain time; the net-shaped framework is an absorbable magnesium alloy, so that the net-shaped framework can be taken out without a secondary operation, and the pain of a patient is greatly reduced; the absorbable magnesium alloy mesh skeleton is embedded into the prosthesis, and the problems of possible membrane exposure and the like caused by abrasion and stimulation to mucous membranes and soft tissues do not exist.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, many modifications and substitutions can be made without departing from the technical principle of the present invention, and these modifications and substitutions should also be regarded as the protection scope of the present invention.

Claims

1. A dental bone tissue repair system is characterized by comprising a mesh framework which can be absorbed by a human body and a repair body which coats the mesh framework and can be absorbed by the human body, wherein a biological shielding film which coats the repair body is arranged on the outer surface of the repair body.

2. The oral bone tissue repair system of claim 1, wherein the mesh skeleton has a fixture hole formed at an edge thereof, and a fixture pin is inserted into the fixture hole.

3. The oral bone tissue repair system of claim 2, wherein the number of the fixture holes is 1-3, and the fixture holes are penetrated with the fixture pins.

4. The oral bone tissue repair system according to claim 1, wherein the mesh skeleton has a thickness of 0.1-0.5mm.

5. The oral bone tissue repair system of claim 1, wherein the mesh skeleton is made of an absorbable magnesium alloy.

6. The system for repairing oral bone tissue according to claim 1, wherein the prosthesis comprises 1-20% of collagen derived from animal.