CN106361468A - Bone repair system for large-stage bone defect - Google Patents
Bone repair system for large-stage bone defect Download PDFInfo
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- CN106361468A CN106361468A CN201610740327.1A CN201610740327A CN106361468A CN 106361468 A CN106361468 A CN 106361468A CN 201610740327 A CN201610740327 A CN 201610740327A CN 106361468 A CN106361468 A CN 106361468A
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- bone
- megastage
- support frame
- supporting frame
- defect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2875—Skull or cranium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/24—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30576—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs
- A61F2002/30578—Special structural features of bone or joint prostheses not otherwise provided for with extending fixation tabs having apertures, e.g. for receiving fixation screws
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30971—Laminates, i.e. layered products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Abstract
The invention provides a bone repair system for large-stage bone defect. The bone repair system comprises a supporting frame and a bone repair material, wherein grids are arranged on the supporting frame; convex bodies are arranged at the outer side of the supporting frame; screw holes are formed in the convex bodies; screws are movably connected to the interiors of the screw holes; the supporting frame is made from a high molecular polymer material or a metal material; the supporting frame is embedded in the bone repair material; and the bone repair material mainly comprise ingredients of collagen, calcium salt and growth factors. By combining the bearing and supporting effects of the supporting frame with the effect of the bone repair material of promoting bone regeneration, bony union of the large-stage bone defect is achieved; and the supporting frame, the convex bodies and the screws are made from a compound of the polylactide copolymer or blend high molecular material and magnesium salt or the metal material of magnesium or magnesium-based alloy, and the materials, after existing in a human body, for a certain duration, can be automatically degraded by the human body and can automatically disappear, so that adverse reactions, and even the risk of infection, caused by long-time existence in the human body are avoided.
Description
Technical field
The invention belongs to bone defect healing field, more particularly, to a kind of Bone Defect Repari system of megastage Cranial defect.
Background technology
The reparation of bulk Cranial defect and reconstruction one that congenital osteopathia, wound, infection or tumor resected bone etc. cause
It is directly a difficult problem and the study hotspot of field of orthopaedics.Although traditional autologous bone transplanting skeletonization effect is good, bone resource less it is difficult to
Repair the Cranial defect of larger area, and complex operation, allogenic bone transplantation, artificial substituent's displacement, Limb lengthening Transfer all exist
Clinically applied, but all had some limitations, such as, due to titanium alloy web plate have good biocompatibility,
The advantages of avirulence and high intensity, is widely used in the clinical practice that skull is repaired, but because titanium alloy is in human body
Can not be degraded, patient often has heavier insecurity, especially for the patient of megastage Cranial defect, large area titanium alloy
Constriction patient can be made to cause headache, dizziness, be afraid of the syndromes such as vibration and rejection to titanium alloy, overlong time may
The problems such as infection can be caused;And in child's skull repair process, because child's skull is in the stage of development, skull can be constantly
Growth changes, and because titanium alloy web plate will not increase, child's skull can be caused asymmetric, the brain development of child is caused
Impact.
Content of the invention
The present invention provides a kind of light weight, promotes osteanagenesis, the Bone Defect Repari system of the megastage Cranial defect of degradable.
For solving above-mentioned technical problem, the technical solution used in the present invention is: a kind of Bone Defect Repari system of megastage Cranial defect
System, including support frame and bone renovating material, is provided with grid in described support frame, is provided with the outside of described support frame
Convex body, is provided with screw hole on described convex body, is connected with screw in described screw hole, and the material of described support frame is
Polymerization macromolecule material or metal material, described support frame is embedded by described bone renovating material, bone renovating material with described
The shape of support frame frame is identical, and the main component of described bone renovating material is collagen protein, calcium salt and somatomedin.
Further, the material of described convex body and described screw is polymerization macromolecule material or metal material.
Further, described polymerization macromolecule material is polyactide copolymer or the complex of blend and magnesium salt.
Further, described metal material is magnesium or magnesium base alloy.
Further, the shape of described support frame can be planar as, tubulose or irregular polyhedronses.
Further, also include porous insulation film, described porous insulation film covers the outer surface in described bone renovating material.
Further, the thickness of described porous insulation film is 0.5mm-2mm, and aperture is 5um-100um.
Further, described convex body is no less than 3.
Further, the cylinder vertical with described support frame is provided with the drift angle of described grid, described cylinder is in
Reversed acanthoid.
Further, the length of described cylinder is in 2mm-10mm, a diameter of 2mm-5mm.
Compared with prior art, the present invention has the advantage that with beneficial effect is: 1, utilizes support frame and Bone Defect Repari material
The Bone Defect Repari system of material embedding, the load-bearing of support frame, supporting role and bone renovating material promote the effect of osteanagenesis, and existing
Using titanium alloy web plate, the reparation of megastage Cranial defect is compared in technology, alleviate patient and brought due to the weight of head
Constriction, in conjunction with the facilitation of bone renovating material, decreases the convalescent period of patient;2nd, support frame, convex body and screw are all adopted
With the metal material of polyactide copolymer or blend macromolecular material and magnesium salt complex or magnesium, magnesium base alloy, these materials
In human body internal memory over time, automatically can be degraded disappearances by human body, it is to avoid produce in long-term existence human body bad instead
Should, or even the danger of infection occurs.
Brief description
Fig. 1 is a kind of structural representation of the support frame of Bone Defect Repari system of the present invention Cranial defect of megastage.
Fig. 2 is a kind of decomposition texture schematic diagram of the Bone Defect Repari system of the present invention Cranial defect of megastage.
Fig. 3 is a kind of embedding structural representation of the Bone Defect Repari system of the present invention Cranial defect of megastage.
In figure: 1- support frame;2- bone renovating material;3- grid;4- convex body;5- screw hole;6- screw;7- porous insulation
Film;8- cylinder.
Specific embodiment
Below in conjunction with the accompanying drawings the specific embodiment of the present invention is elaborated.
As shown in Figure 1, Figure 2 and Figure 3, a kind of Bone Defect Repari system of megastage Cranial defect, including support frame 1 and Bone Defect Repari
Material 2, is provided with grid 3 in described support frame 1, is provided with convex body 4 in the outside of described support frame 1, on described convex body 4
It is provided with screw hole 5, described screw hole 5 is connected with screw 6, the material of described support frame 1 is polymerization macromolecule material
Material or metal material, described support frame 1 embeds by described bone renovating material 2, bone renovating material 2 and described support frame 1
Shape is identical, and the main component of described bone renovating material 2 is collagen protein, calcium salt and somatomedin, will using bone renovating material 2
The structure of support frame 1 embedding is mainly used in load-bearing and props up as the Bone Defect Repari system of megastage Cranial defect, wherein support frame 1
Support acts on, and can be the geometry of single or multiple lift, and support frame 1 material is polymerization macromolecule material or metal material, its
Middle polymerization macromolecule material is the complex of polyactide copolymer or blend and magnesium salt, and the molecular weight of wherein poly- friendship fat is higher than
20kda, magnesium salt is magnesium carbonate or magnesium phosphate, and metal material is mainly magnesium or magnesium base alloy, and these materials can play very well
Supporting role, and can be degraded by human body, and human body is not injured;Bone renovating material 2 has good promotion bone again
Raw ability, its main component is collagen protein, calcium salt and somatomedin, and wherein collagen protein is i type and/or iii type glue
Former albumen, calcium salt is hydroxyapatite or calcium phosphate, and somatomedin is nell-1 albumen, therefore can be used as bone renovating material
Material has allogeneic decalcified bone matrix, bone- xenograft decalcified bone matrix etc..Described convex body 4 and screw 6 can be solid by support frame 1
Be scheduled on Cranial defect position, the diameter of screw 6 between 0.5mm-5mm, length between 1mm-50mm, described convex body 4 and described
The material of screw 6 is polymerization macromolecule material or metal material, can disappear in people's vivo degradation as support frame 1.
Further, the shape of described support frame 1 can be planar as, tubulose or irregular polyhedronses, support frame 1
Shape can be corresponding from the shape of different Cranial defect, be not limited to any shape, and bone renovating material 2 with support
The shape of framework 1 is identical, disclosure satisfy that the case to megastage Cranial defect of different shapes carries out Bone Defect Repari.
Further, also include porous insulation film 7, described porous insulation film 7 covers the appearance in described bone renovating material 2
Face, the thickness of described porous insulation film 7 is 0.5mm-2mm, and aperture is 5um-100um, the Main Function of porous insulation film 7 be by
Soft tissue is isolated with osseous tissue, prevents growth position that is too fast due to soft tissue growth and occupying osseous tissue, in addition, porous
Obstruct membrane 7 is by collagen protein or collagen protein and polysaccharide or collagen protein, polysaccharide and calcium salt Material cladding, wherein collagen egg
It is i collagen type in vain, polysaccharide is shitosan, and calcium salt is hydroxyapatite or calcium phosphate, and therefore, porous insulation film 7 also can quilt
Human body is degraded.
Further, described convex body 4 is no less than 3 it is ensured that support frame 1 can be good at being fixed on Cranial defect position.
Further, the cylinder 8 vertical with described support frame 1, described cylinder are provided with the drift angle of described grid 3
8 is in reversed acanthoid, and, in 2mm-10mm, a diameter of 2mm-5mm, when bone renovating material 2 enters to support frame 1 for the length of described cylinder 8
During row embedding, cylinder 8 has certain reinforcement effect to bone renovating material 2.
When Bone Defect Repari being carried out to patient using this megastage Bone Defect Repari system, bone renovating material 2 is carried out with support frame 1
Embedding, produces the megastage Bone Defect Repari system being consistent with patient trauma's area, using the screw 6 on convex body 4, it is carried out solid
Fixed, cover porous insulation film in the outer surface of bone renovating material 2, reach the purpose of isolation soft tissue and osseous tissue, through one section
Time, under the facilitation of bone renovating material 2, the osteanagenesis of patient trauma position, wound healing, support frame in the patient
1st, convex body 4, screw 6 and porous insulation film 8 all can decompose disappearance in human body, and human body will not be damaged.
Above one embodiment of the present of invention is described in detail, but described content has been only the preferable enforcement of the present invention
Example is it is impossible to be considered the practical range for limiting the present invention.All impartial changes made according to the present patent application scope and improvement
Deng all should still belong within the patent covering scope of the present invention.
Claims (10)
1. a kind of Bone Defect Repari system of megastage Cranial defect it is characterised in that: include support frame (1) and bone renovating material (2),
Grid (3) is provided with described support frame (1), is provided with convex body (4) in the outside of described support frame (1), in described convex body
(4) it is provided with screw hole (5), described screw hole (5) is connected with screw (6), the material of described support frame is poly-
Close macromolecular material or metal material, described support frame is embedded by described bone renovating material, described bone renovating material main
Composition is collagen protein, calcium salt and somatomedin.
2. a kind of megastage Cranial defect according to claim 1 Bone Defect Repari system it is characterised in that: described convex body (4)
It is polymerization macromolecule material or metal material with the material of described screw (6).
3. a kind of megastage Cranial defect according to claim 1 and 2 Bone Defect Repari system it is characterised in that: described polymerization
Macromolecular material is polyactide copolymer or the complex of blend and magnesium salt.
4. a kind of megastage Cranial defect according to claim 1 and 2 Bone Defect Repari system it is characterised in that: described metal
Material is magnesium or magnesium base alloy.
5. a kind of megastage Cranial defect according to claim 1 Bone Defect Repari system it is characterised in that: described support frame
(1) shape is curved, tubulose or irregular polyhedronses.
6. a kind of megastage Cranial defect according to claim 1 Bone Defect Repari system it is characterised in that: also include porous resistance
Barrier film (7), described porous insulation film (7) covers the outer surface in described bone renovating material (2).
7. a kind of megastage Cranial defect according to claim 6 Bone Defect Repari system it is characterised in that: described porous insulation
The thickness of film (7) is 0.3mm-2mm, and aperture is 5um-100um.
8. a kind of megastage Cranial defect according to claim 1 Bone Defect Repari system it is characterised in that: described convex body (4)
No less than 3.
9. a kind of megastage Cranial defect according to claim 1 Bone Defect Repari system it is characterised in that: in described grid
(3) cylinder (8) vertical with described support frame (1) is provided with drift angle, described cylinder (8) is in reversed acanthoid.
10. a kind of megastage Cranial defect according to claim 9 Bone Defect Repari system it is characterised in that: described cylinder (8)
Length in 2mm-10mm, a diameter of 2mm-5mm.
Priority Applications (1)
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CN201610740327.1A CN106361468B (en) | 2016-08-26 | 2016-08-26 | A kind of Bone Defect Repari system of big stage bone defect |
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CN201610740327.1A CN106361468B (en) | 2016-08-26 | 2016-08-26 | A kind of Bone Defect Repari system of big stage bone defect |
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CN106361468A true CN106361468A (en) | 2017-02-01 |
CN106361468B CN106361468B (en) | 2019-01-15 |
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WO2020079597A1 (en) * | 2018-10-16 | 2020-04-23 | Ossdsign Ab | Implants for filling bore holes in bone and methods for filling bore holes in bone |
CN115154654A (en) * | 2022-06-28 | 2022-10-11 | 广东健齿生物科技有限公司 | Oral bone tissue repair system |
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CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
WO2016024248A1 (en) * | 2014-08-14 | 2016-02-18 | Ossdsign Ab | Bone implants for correcting bone defects |
CN206214171U (en) * | 2016-08-26 | 2017-06-06 | 天津市赛宁生物工程技术有限公司 | A kind of Bone Defect Repari device |
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US20120310365A1 (en) * | 2011-05-30 | 2012-12-06 | 3Dceram | Reinforced biocompatible ceramic implant and manufacturing method thereof |
CN103857351A (en) * | 2011-08-22 | 2014-06-11 | 奥斯设计公司 | Implants and methods of using the implants to fill holes in bone tissue |
WO2016024248A1 (en) * | 2014-08-14 | 2016-02-18 | Ossdsign Ab | Bone implants for correcting bone defects |
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WO2020079597A1 (en) * | 2018-10-16 | 2020-04-23 | Ossdsign Ab | Implants for filling bore holes in bone and methods for filling bore holes in bone |
CN115154654A (en) * | 2022-06-28 | 2022-10-11 | 广东健齿生物科技有限公司 | Oral bone tissue repair system |
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