CN110384571A - A kind of large segmental bone defect implantation material and preparation method thereof - Google Patents
A kind of large segmental bone defect implantation material and preparation method thereof Download PDFInfo
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- CN110384571A CN110384571A CN201910769716.0A CN201910769716A CN110384571A CN 110384571 A CN110384571 A CN 110384571A CN 201910769716 A CN201910769716 A CN 201910769716A CN 110384571 A CN110384571 A CN 110384571A
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- receiving part
- fixed plate
- load receiving
- implantation material
- bone defect
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 90
- 239000000463 material Substances 0.000 title claims abstract description 69
- 230000007547 defect Effects 0.000 title claims abstract description 63
- 238000002513 implantation Methods 0.000 title claims abstract description 63
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 230000002950 deficient Effects 0.000 claims abstract description 13
- 239000007943 implant Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 6
- 238000010146 3D printing Methods 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 238000007639 printing Methods 0.000 claims description 5
- 238000007493 shaping process Methods 0.000 claims description 5
- 229910052719 titanium Inorganic materials 0.000 claims description 5
- 239000010936 titanium Substances 0.000 claims description 5
- 229910001362 Ta alloys Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 229910052715 tantalum Inorganic materials 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 239000003462 bioceramic Substances 0.000 claims description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 238000000547 structure data Methods 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 2
- 238000009434 installation Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 4
- 238000011900 installation process Methods 0.000 abstract description 3
- 238000010276 construction Methods 0.000 description 4
- 241000282326 Felis catus Species 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 241000282465 Canis Species 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000005518 electrochemistry Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 210000004409 osteocyte Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000008113 selfheal Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/307—Prostheses for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/3097—Designing or manufacturing processes using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
Landscapes
- Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The present invention provides a kind of large segmental bone defect implantation materials and preparation method thereof, are related to prosthese technical field.Large segmental bone defect implantation material includes for being implanted into the load receiving part of defect, the first fixing piece for the true bone fixation with load receiving part one end and the second fixing piece for the true bone fixation with the load receiving part other end, one end of load receiving part is connected with the first fixing piece, the other end of load receiving part is connected with the second fixing piece, is provided with fixation hole on the first fixing piece and the second fixing piece.Load receiving part is inlaid into defect point during the installation process, and is fixed using the fixation hole at both ends and true bone, it is easy for installation, and can achieve the effect that fixed steadily in the long term.The preparation method of large segmental bone defect implantation material is the form according to defective bone, and preparation meets the product of above-mentioned large segmental bone defect implant structure, keeps the implantation material being prepared easy for installation, reduces the operation difficulty of operation.
Description
Technical field
The present invention relates to prosthese technical fields, in particular to a kind of large segmental bone defect implantation material and preparation method thereof.
Background technique
With the continuous improvement of people's living standards, more and more people like raising pet, especially cat, canine is doted on
Object, according to the data statistics of " Chinese pet industry white paper in 2018 " it is found that Chinese pet (dog cat) consumption market in 2018
Scale reaches 170,800,000,000, increases by 27% on a year-on-year basis.But " white paper " is shown, medical service charge accounting is most in pet service consumption
Height, dog owner spends 1557.2 yuan every year on Medical pet, but pet owner is up to the unsatisfied ratio of medical services
47.1%.Pet fracture compound comminuted because caused by by vehicle crash or from high falling, or because of big section caused by infection, tumour etc.
Bone defect needs to carry out bone implant.Therefore, ever-increasing market demand, big section of the exploitation for pet cat, pet dog are faced
Bone defect implantation material be very it is necessary to.
Generally higher than the large segmental bone defect of 2cm then can not self-heal, need to carry out operative treatment, namely need to carry out people
The treatment of work bone implant.It is well known that being clinically bone collection and bone implant using most methods using allograph bone, but due to it
Limited source and the infection and necrosis for being likely to result in implant site, cause to treat unsuccessful.
Currently, being applied to the large segmental bone defect implantation material of human body mainly there are the implantation materials such as bone cement and ceramics, but it is applied to
The report of the implantation material of canine is also less, and it is fixed resourcefulness and is fixed using additional fixed structure is increased, this to plant
The complexity for entering operation increases.
Summary of the invention
The purpose of the present invention is to provide a kind of large segmental bone defect implantation materials, it is intended to keep implantation material easy for installation, and make to plant
Entering object steady in a long-term can be fixed.
Another object of the present invention is to provide a kind of preparation method of large segmental bone defect implantation material, the plant being prepared
Enter that object structure is simple, easy for installation, reduces the complexity of surgical procedure.
The present invention is implemented as follows:
The present invention provides a kind of large segmental bone defect implantation material, including for being implanted into defect load receiving part, for hold
First fixing piece of the true bone fixation of weight portion one end and the second fixing piece for the true bone fixation with the load receiving part other end, load-bearing
The one end in portion is connected with the first fixing piece, and the other end of load receiving part is connected with the second fixing piece, and the first fixing piece and second is fixed
Fixation hole is provided on part.
Further, in preferred embodiments of the present invention, load receiving part is hollow tubular, and load receiving part is in porous structure.
Further, in preferred embodiments of the present invention, the hole on load receiving part is hexagonal hole, hexagonal hole
Aperture is 500-600 μm.
Further, in preferred embodiments of the present invention, the first fixing piece includes be connected to load receiving part side first
Fixed plate and second fixed plate opposite with the first fixed plate are provided at least one in the first fixed plate and the second fixed plate
Fixation hole.
Further, in preferred embodiments of the present invention, the second fixing piece includes the third for being connected to load receiving part side
Fixed plate and fourth fixed plate opposite with third fixed plate are provided at least one in third fixed plate and third fixed plate
Fixation hole.
Further, in preferred embodiments of the present invention, the first fixed plate, the second fixed plate, third fixed plate and
Four fixed plates are arc panel, and radian is consistent with the end radian of load receiving part.
Further, in preferred embodiments of the present invention, the first fixed plate, the second fixed plate, third fixed plate and
Fixation hole in four fixed plates farthest away from corresponding load receiving part end is 0.8- at a distance from the end of corresponding load receiving part
1.2cm。
Further, in preferred embodiments of the present invention, the material of large segmental bone defect implantation material is selected from pure titanium, titanium closes
At least one of golden, pure tantalum, tantalum alloy, stainless steel, polyether-ether-ketone and bioceramic.
Further, it in preferred embodiments of the present invention, is respectively provided on load receiving part, the first fixing piece and the second fixing piece
There is bionical layer.
The present invention also provides a kind of preparation methods of large segmental bone defect implantation material, comprising: according to the form of defective bone, preparation
Large segmental bone defect implantation material out.
The beneficial effect of large segmental bone defect implantation material provided in an embodiment of the present invention is: the present invention obtains by above-mentioned design
Large segmental bone defect implantation material, the first fixing piece and the second fixing piece is respectively set by the both ends in load receiving part, and
Setting during the installation process inlays load receiving part convenient for the fixation hole being fixed with true bone on one fixing piece and the second fixing piece
Enter defect point, and is fixed using the fixation hole at both ends and true bone, it is easy for installation, and effect fixed steadily in the long term can be reached
Fruit.
The embodiment of the invention also provides a kind of preparation methods of large segmental bone defect implantation material, according to the shape of defective bone
State, preparation meet the product of above-mentioned large segmental bone defect implant structure, keep the implantation material being prepared easy for installation, reduce hand
The operation difficulty of art.
Detailed description of the invention
It, below will be to use required in embodiment in order to illustrate more clearly of the technical solution of embodiment of the present invention
Attached drawing be briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not to be seen as
It is the restriction to range, it for those of ordinary skill in the art, without creative efforts, can be with root
Other relevant attached drawings are obtained according to these attached drawings.
Fig. 1 is the first viewing angle constructions schematic diagram of the large segmental bone defect implantation material that embodiment of the present invention provides；
Fig. 2 is the second viewing angle constructions schematic diagram of the large segmental bone defect implantation material that embodiment of the present invention provides；
Fig. 3 is the third viewing angle constructions schematic diagram for the large segmental bone defect implantation material that embodiment of the present invention provides；
Fig. 4 is the enlarged drawing in IVth area Tu1Zhong.
Icon: 100- large segmental bone defect implantation material；101- fixation hole；110- load receiving part；The first fixing piece of 120-；121-
One fixed plate；The second fixed plate of 122-；The second fixing piece of 130-；131- third fixed plate；The 4th fixed plate of 132-.
Specific embodiment
To keep the purposes, technical schemes and advantages of embodiment of the present invention clearer, implement below in conjunction with the present invention
The technical solution in embodiment of the present invention is clearly and completely described in attached drawing in mode, it is clear that described reality
The mode of applying is some embodiments of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ability
Domain those of ordinary skill every other embodiment obtained without creative efforts, belongs to the present invention
The range of protection.Therefore, the detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit below and is wanted
The scope of the present invention of protection is sought, but is merely representative of selected embodiment of the invention.Based on the embodiment in the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts belongs to this
Invent the range of protection.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " up time
The orientation or positional relationship of the instructions such as needle ", " counterclockwise " is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of
The description present invention and simplified description, rather than the equipment of indication or suggestion meaning or element must have a particular orientation, with spy
Fixed orientation construction and operation, therefore be not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more of the features.In the description of the present invention, the meaning of " plurality " is two or more,
Unless otherwise specifically defined.
In the present invention unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " fixation " etc.
Term shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integral；It can be mechanical connect
It connects, is also possible to be electrically connected；It can be directly connected, can also can be in two elements indirectly connected through an intermediary
The interaction relationship of the connection in portion or two elements.It for the ordinary skill in the art, can be according to specific feelings
Condition understands the concrete meaning of above-mentioned term in the present invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature second feature "upper" or "lower"
It may include that the first and second features directly contact, also may include that the first and second features are not direct contacts but pass through it
Between other characterisation contact.Moreover, fisrt feature includes the first spy above the second feature " above ", " above " and " above "
Sign is right above second feature and oblique upper, or is merely representative of first feature horizontal height higher than second feature.Fisrt feature exists
Second feature " under ", " lower section " and " following " include that fisrt feature is directly below and diagonally below the second feature, or is merely representative of
First feature horizontal height is less than second feature.
Fig. 1-3 is please referred to, the embodiment of the present invention provides a kind of large segmental bone defect implantation material 100, including for being implanted into defect
The load receiving part 110 at position, for the true bone fixation with 110 one end of load receiving part the first fixing piece 120 and be used for and load receiving part 110
Second fixing piece 130 of the true bone fixation of the other end.Utilize first fixing piece 120 at 110 both ends of load receiving part and the second fixing piece
130 are fixed with true bone, to realize the fixation stable for a long time of load receiving part 110.
Specifically, one end of load receiving part 110 is connected with the first fixing piece 120, and the other end of load receiving part 110 and second is fixed
Part 130 is connected, and is provided with fixation hole 101 on the first fixing piece 120 and the second fixing piece 130.First fixing piece 120 and second
Fixing piece 130 can be integrally formed mode with load receiving part 110, be formed convenient for being prepared by 3D printing.In the first fixing piece
120 and second are respectively provided with fixation hole 101 on fixing piece 130, convenient for being fixed by fixing pieces such as screws.Preferably, fixed
Hole 101 can be threaded hole, to reinforce the stability of connection.
Further, load receiving part 110 is hollow tubular, and load receiving part 110 is in porous structure.Tubular is not stringent circle
Cylinder is the class tubular structure being adapted with the bone shaped of defect point.The load receiving part 110 of porous structure can be the increasing of osteocyte
It grows and grows and provide better space and environment, also can guarantee intensity while the elasticity modulus of implant is effectively reduced, mention
High implantation compatibility can reduce or avoid the rejection after implantation with true bone tissue.
Incorporated by reference to Fig. 1 and Fig. 4, in preferred embodiments of the present invention, the hole on load receiving part 110 is hexagonal hole, just
The aperture of hexagonal hole is 500-600 μm.Hexagonal hole has symmetry, and compared to the shape in general hole, stress is more
Uniformly, the service life of implantation material can further be promoted.The aperture of hexagonal hole, which is set as 500-600 μm, to be advisable, specifically
It can be adjusted according to the specific size of load receiving part 110.The aperture of hexagonal hole is conventional understanding, can be regular hexagon institute
Circular configuration radius.
Further, the first fixing piece 120 includes being connected to the first fixed plate 121 of 110 side of load receiving part and with first
It is solid to be provided at least one in first fixed plate 121 and the second fixed plate 122 for the second opposite fixed plate 122 of fixed plate 121
Determine hole 101.It is respectively provided with fixed plate in the two sides of load receiving part 110, the stability of fixed structure can be increased, by fixed by first
Plate 121 and the second fixed plate 122 are set as symmetrical form, also make integrally-built be more uniformly stressed.
Equally, the second fixing piece 130 includes being connected to the third fixed plate 131 of 110 side of load receiving part and fixing with third
The 4th opposite fixed plate 132 of plate 131 is provided at least one fixation hole in third fixed plate 131 and third fixed plate 131
101.Overall structure is in symmetrical above and below, symmetrical form, and uniform force is more preferable, and fixed stability is higher, increases
The service life of entire implantation material.
In preferred embodiments of the present invention, the first fixed plate 121, the second fixed plate 122, third fixed plate 131 and
Four fixed plates 132 are arc panel, and the end radian of radian and load receiving part 110 is adapted, so that the first fixed plate 121, the
The end edge of two fixed plates 122, third fixed plate 131 and the 4th fixed plate 132 and the end edge of corresponding load receiving part 110
It fits.By the way of arc-shaped transition, the influence to blood can be reduced, increases comforts of use.
Further, in the first fixed plate 121, the second fixed plate 122, third fixed plate 131 and the 4th fixed plate 132 most
Fixation hole 101 far from corresponding 110 end of load receiving part is 0.8-1.2cm at a distance from the end of corresponding load receiving part 110.Gu
The number for determining hole 101 is unlimited, 2 fixation holes 101 can be arranged, in each fixed plate to achieve the effect that more stable support.
Distance of the fixation hole 101 of distalmost end apart from 110 end of load receiving part is advisable with 1cm or so, can preferably be consolidated within this range
Determine load receiving part 110, reaches more firm fixed effect.Fixation hole 101 can be respectively provided with 2 in each fixed plate, along vertical
Direction equidistantly arranges.
Further, the material of large segmental bone defect implantation material 100 be selected from pure titanium, titanium alloy, pure tantalum, tantalum alloy, stainless steel,
At least one of polyether-ether-ketone and bioceramic.Above several existing materials are adapted to as large segmental bone defect implantation material
100 material, it is not easy to rejection occur.Wherein, the application of pure titanium, titanium alloy, pure tantalum, tantalum alloy and stainless steel is wider
It is general.
In preferred embodiments of the present invention, it is respectively provided on load receiving part 110, the first fixing piece 120 and the second fixing piece 130
There is bionical layer, bionical layer can be further improved the biocompatibility of implantation material.Bionical layer can using differential arc oxidation (SMAT),
The technologies such as collosol and gel, electrochemistry are handled, and implant surface is made to obtain one layer of coating structure, and the material of bionical layer can be
Hydroxyapatite.
You need to add is that large segmental bone defect implantation material 100 provided in an embodiment of the present invention, which is applied to pet dog, is implanted into hand
It is discontented to existing Medical pet can to improve people for the growing phenomenon of pet dog large segmental bone defect implant surgery for art
Status, promote the development of Medical pet.
The embodiment of the present invention also provides a kind of preparation method of large segmental bone defect implantation material, comprising: according to the shape of defective bone
State prepares large segmental bone defect implantation material.According to the form of defective bone, it is adapted the form of load receiving part and defective bone, is passed through
Prior art preparation large segmental bone defect implantation material.
Preferably, the preparation of large segmental bone defect implantation material uses the disposable printing shaping of 3D printing technique, reduces complexity
Cumbersome process, has effectively saved cost.
Specifically, the preparation process of large segmental bone defect implantation material includes: to acquire the prototype structure data of defective bone, according to original
Beginning structured data carries out structure and designs the threedimensional model to form implantation material；Obtained threedimensional model is imported into 3D laser melting equipment
Control terminal, disposable printing shaping.Wherein, the prototype structure data for acquiring defective bone can use the side of three-D CT scanning
Formula can go out the implantation material threedimensional model that size and shape matches with original defective bone using software designs such as Magics,
The radian of load receiving part and fixing piece is required to optimize setting according to the radian of original defective bone, is affixed it with raw bone
It closes.The shape, size in hole on load receiving part are not done excessively repeat herein referring to the introduction about large segmental bone defect implant structure.
It should be noted that the technique for using 3D laser melting (SLM) equipment to be printed is the prior art, it is layered to cut
Disposable printing shaping after piece and parameter setting.
In some embodiments, the preparation process of large segmental bone defect implantation material further include: in the molding implantation material of 3D printing
Surface coats bionical layer；The material of bionical layer can be hydroxyapatite.The coating processes of bionical layer can use the prior art,
Such as differential arc oxidation (SMAT), collosol and gel, electrochemistry technology.
In conclusion a kind of large segmental bone defect implantation material provided in an embodiment of the present invention, by the both ends of load receiving part point
First fixing piece and the second fixing piece are not set, and setting is convenient for being consolidated with true bone on the first fixing piece and the second fixing piece
Load receiving part is inlaid into defect point during the installation process, and is fixed using the fixation hole at both ends and true bone by fixed fixation hole,
It is easy for installation, and can achieve the effect that fixed steadily in the long term.Load receiving part uses porous structure, and porous structure is the growth of cell
Space is provided, osteoconductive and Integrated implant is improved, elasticity modulus can also be reduced.
A kind of preparation method of large segmental bone defect implantation material provided in an embodiment of the present invention, according to the form of defective bone,
Preparation meets the product of above-mentioned large segmental bone defect implant structure, keeps the implantation material being prepared easy for installation, reduces operation
Operation difficulty.
The foregoing is merely the preferred embodiment of the present invention, are not intended to restrict the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of large segmental bone defect implantation material, which is characterized in that including for being implanted into defect load receiving part, for it is described
First fixing piece of the true bone fixation of load receiving part one end and for the second fixed of the true bone fixation with the load receiving part other end
Part, one end of the load receiving part are connected with first fixing piece, the other end of the load receiving part and the second fixing piece phase
Even, fixation hole is provided on first fixing piece and second fixing piece.
2. large segmental bone defect implantation material according to claim 1, which is characterized in that the load receiving part is hollow tubular, and
The load receiving part is in porous structure.
3. large segmental bone defect implantation material according to claim 2, which is characterized in that the hole on the load receiving part is positive six sides
Shape hole, the aperture of the hexagonal hole are 500-600 μm.
4. large segmental bone defect implantation material according to claim 2, which is characterized in that first fixing piece includes being connected to
First fixed plate of the load receiving part side and second fixed plate opposite with first fixed plate, first fixed plate and
At least one fixation hole is provided in second fixed plate.
5. large segmental bone defect implantation material according to claim 4, which is characterized in that second fixing piece includes being connected to
The third fixed plate of the load receiving part side and fourth fixed plate opposite with the third fixed plate, the third fixed plate and
At least one fixation hole is provided in the third fixed plate.
6. large segmental bone defect implantation material according to claim 5, which is characterized in that first fixed plate, described second
Fixed plate, the third fixed plate and the 4th fixed plate are arc panel, and the end radian of radian and the load receiving part
It is consistent.
7. large segmental bone defect implantation material according to claim 5, which is characterized in that first fixed plate, described second
In fixed plate, the third fixed plate and the 4th fixed plate farthest away from the corresponding load receiving part end fixation hole with it is right
The distance of the end for the load receiving part answered is 0.8-1.2cm.
8. large segmental bone defect implantation material according to claim 1, which is characterized in that the material of the large segmental bone defect implantation material
Matter is selected from least one of pure titanium, titanium alloy, pure tantalum, tantalum alloy, stainless steel, polyether-ether-ketone and bioceramic.
9. large segmental bone defect implantation material according to claim 1, which is characterized in that the load receiving part, described first are fixed
Bionical layer is provided on part and second fixing piece.
10. the preparation method of large segmental bone defect implantation material described in any one of claim 1-9 characterized by comprising according to
The form of defective bone prepares the large segmental bone defect implantation material；
Preferably, the preparation of the large segmental bone defect implantation material uses the disposable printing shaping of 3D printing technique；
Preferably, the preparation process of the large segmental bone defect implantation material includes: to acquire the prototype structure data of defective bone, according to original
Beginning structured data carries out structure and designs the threedimensional model to form implantation material；Obtained threedimensional model is imported into 3D laser melting equipment
Control terminal, disposable printing shaping；
It is highly preferred that the preparation process of the large segmental bone defect implantation material further include: applied in the molding implant surface of 3D printing
Cover bionical layer；
It is further preferred that the material of the bionical layer is hydroxyapatite.
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Application publication date: 20191029 |