CN206518623U - A kind of artificial periosteum for hand Bone Defect Repari - Google Patents
A kind of artificial periosteum for hand Bone Defect Repari Download PDFInfo
- Publication number
- CN206518623U CN206518623U CN201621128186.XU CN201621128186U CN206518623U CN 206518623 U CN206518623 U CN 206518623U CN 201621128186 U CN201621128186 U CN 201621128186U CN 206518623 U CN206518623 U CN 206518623U
- Authority
- CN
- China
- Prior art keywords
- periosteum
- length
- artificial
- drops
- bone defect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Prostheses (AREA)
Abstract
The utility model is related to a kind of artificial periosteum for hand Bone Defect Repari, including：First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50 500um, and porosity is 10 30%；Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material, and average pore size is 50 500um, and porosity is 50 95%；Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material.Artificial periosteum of the present utility model has layer stereo structure, and the loose and porous structure of lower section is conducive to artificial periosteum to be fixed in autologous bone, is difficult to slip displacement；The smooth surface structure of top can effectively prevent connective soft tissue hyperplasia and grow into inside bone tissue, it is to avoid reduce the skeletonization space of bone tissue.
Description
Technical field
The utility model is related to technical field of medical instruments, more particularly to a kind of artificial periosteum for hand Bone Defect Repari.
Background technology
Fracture, bone nonunion, bone delay in healing etc. are clinically common orthopaedic diseases, except there is bone tissue defect, this
A little diseases are also directed to the defect of periosteum.Therefore, while bone defect healing is carried out, the defect of periosteum should also be repaiied
It is multiple, to reach more preferable clinical repair effect.However, there is presently no the artificial periosteum product for being available for Clinical practice.
Do not have special periosteum for repairing product clinically at present, some membranaceous implantation materials are used as replacing for periosteum
Generation and reparation, this kind of material mainly have acellular matrix film, degradable polymer film and collagem membrane etc..But these membranaceous implantation
Material is single layered porous structure, although Cranial defect face can be repaired, but also easily cause growing into for connective soft tissue,
Cause hand Bone Defect Repari effect not good.
Utility model content
The technical problems to be solved in the utility model is, is single layered porous structure for periosteum for repairing product in the prior art
Easily causing the problem of connective soft tissue is grown into, there is provided a kind of artificial periosteum for hand Bone Defect Repari.
In order to solve the above-mentioned technical problem, the utility model provides a kind of artificial periosteum for hand Bone Defect Repari, bag
Include：
First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50-500um,
Porosity is 10-30%；
Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material,
And average pore size is 50-500um, porosity is 50-95%；
Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the cast layer thickness is
0.01-0.05mm, first porous layer thickness is 0.02-0.3mm, and the thickness of second porous layer is 0.02-0.15mm.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the cast layer by PLA,
Poly(D,L-lactide-co-glycolide or polycaprolactone are made；First porous layer and the second porous layer by nanometer calcium microcosmic salt with
The mineralized collagen of collagen composite is made.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is rectangular
Shape, length is 20-120mm, and width is 25-60mm, and the corner of rectangle is handled through rounding, and the radius of rounding is 5-
30mm。
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is for slapping
The periosteum of Cranial defect, and the rectangle length is 60-120mm；Or the artificial periosteum is the bone for proximal phalanx defect
Film, the rectangle length is 30-80mm；Or the artificial periosteum is periosteum for middle phalanx defect, and the rectangle
Length is 20-60mm；Or the artificial periosteum is the periosteum for distal phalanx defect, and the rectangle length is 10-
40mm。
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is in water droplet
Shape, includes the drops bottom of tiling or the winding for phalanges or metacarpal bone defect, and for the flat of phalanges or metacarpal bone defect
The drops tip of paving；And the length of drops tip to the drops bottom is 10-120mm, the drops bottom
Width is 25-60mm.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is for slapping
The periosteum of Cranial defect, and the length of drops tip to drops bottom is 60-120mm；Or the artificial periosteum is
Length for the periosteum of proximal phalanx defect, and drops tip to drops bottom is 30-80mm；Or the people
Work periosteum is the periosteum for middle phalanx defect, and the length of drops tip to drops bottom is 20-60mm；Or
Artificial periosteum described in person is periosteum for distal phalanx defect, and length of the drops tip to drops bottom is
10-40mm。
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is in convex,
Include the convex portion of the tiling for phalanges or metacarpal bone defect, and tiling or the winding for phalanges or metacarpal bone defect convex bottom
Portion；The width of the convex portion is 25-60mm, and the length of the convex portion to convex bottom is 10-120mm, the convex bottom
Length is 5-60mm.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, each rectangle of the convex
Corner is handled through rounding, and the radius of rounding is 5-30mm.
According in the artificial periosteum described in the utility model for hand Bone Defect Repari, the artificial periosteum is for slapping
The periosteum of Cranial defect, and the convex portion is 60-120mm to the length of convex bottom, the length of the convex bottom is 20-
60mm；Or the artificial periosteum is periosteum for proximal phalanx defect, and the convex portion to the length of convex bottom be 30-
80mm, the length of the convex bottom is 20-60mm；Or the artificial periosteum is the periosteum for middle phalanx defect, and
The convex portion is 20-60mm to the length of convex bottom, and the length of the convex bottom is 10-40mm；Or the artificial bone
Film is periosteum for distal phalanx defect, and the convex portion to the length of convex bottom be 10-40mm, the convex bottom
Length is 5-30mm.
Implement the artificial periosteum of the present utility model for hand Bone Defect Repari, have the advantages that：The utility model
Artificial periosteum there is layer stereo structure, the loose and porous structure of lower section is conducive to artificial periosteum to be consolidated in autologous bone
It is fixed, it is difficult to slip displacement；The smooth surface structure of top can effectively prevent connective soft tissue hyperplasia and grow into bone tissue
Portion, it is to avoid reduce the skeletonization space of bone tissue.In addition, the utility model is also improved by the shape to artificial periosteum, make
Its more identical periosteum defect shape, it is to avoid cut the waste produced, reduces patient suffering and medical expense.
Brief description of the drawings
Fig. 1 is to be illustrated according to the cross-section structure of the artificial periosteum for hand Bone Defect Repari of the utility model preferred embodiment
Figure；
Fig. 2 is that human body hand bone dissects schematic diagram；
Fig. 3 is the schematic shapes of the artificial periosteum for hand Bone Defect Repari according to the utility model first embodiment；
Fig. 4 is the schematic shapes of the artificial periosteum for hand Bone Defect Repari according to the utility model second embodiment；
Fig. 5 is the schematic shapes of the artificial periosteum for hand Bone Defect Repari according to the utility model 3rd embodiment.
Embodiment
It is new below in conjunction with this practicality to make the purpose, technical scheme and advantage of the utility model embodiment clearer
Accompanying drawing in type embodiment, the technical scheme in the utility model embodiment is clearly and completely described, it is clear that retouched
The embodiment stated is a part of embodiment of the present utility model, rather than whole embodiments.Based on the reality in the utility model
Apply example, the every other embodiment that those of ordinary skill in the art are obtained on the premise of creative work is not made, all
Belong to the scope of the utility model protection.
Referring to Fig. 1, being the section of the artificial periosteum for hand Bone Defect Repari according to the utility model preferred embodiment
Structural representation.As shown in figure 1, the artificial periosteum for hand Bone Defect Repari that the embodiment is provided includes setting successively from bottom to up
The first porous layer 3, the second porous layer 2 and the cast layer 1 put.This is preferably for thickness of the artificial periosteum of hand Bone Defect Repari
0.05 arrives 0.5mm.
Wherein the first porous layer 3 is made up of Biodegradable material, and the average pore size of first porous layer 3 is 50-
500um, porosity is 10-30%.Preferably, first porous layer 3 by nanometer calcium microcosmic salt and collagen composite mineralized collagen system
Into, or be composited by nanometer calcium microcosmic salt and medical macromolecular materials.And the thickness of the first porous layer 3 is preferably 0.02-
0.3mm。
Second porous layer 2 is located on the first porous layer 3, and second porous layer can also be made up of Biodegradable material, and
Average pore size is 50-500um, and porosity is 50-95%.Preferably, second porous layer 2 is by nanometer calcium microcosmic salt and collagen composite
Mineralized collagen be made, and the thickness of the second porous layer 2 is preferably 0.02-0.15mm.
Cast layer 1 is located on the second porous layer 2, and the cast layer is made up of Biodegradable material.Preferably, the cast layer
1 is made up of PLA (PLA), Poly(D,L-lactide-co-glycolide (PLGA) or polycaprolactone (PCL), and the thickness of cast layer 1
Preferably 0.01-0.05mm.
Artificial periosteum of the present utility model can enter in the operation of hand Bone Defect Repari to the bone defect healing region after bone grafting
Row cladding, reaches the purpose for substituting and rebuilding periosteum, the risk of reduction bone-grafting material abjection, and prevent the groups such as muscle, fat
Knit and be pressed into Cranial defect position, influence repairing effect.Specifically, artificial periosteum of the present utility model has layer stereo knot
Structure, artificial periosteum when for hand Bone Defect Repari, can be wound or be laid on the metacarpal bone of hand or phalanges, and now first
Porous layer 3 is fitted with hand bone down, and its loose and porous structure is conducive to artificial periosteum to be fixed in autologous bone, is difficult to slip
Displacement；Meanwhile, cast layer 1 is contacted with connective soft tissue upward, and its smooth surface can effectively prevent connective soft tissue from increasing
Give birth to and grow into inside bone tissue, it is to avoid reduce the skeletonization space of bone tissue.
Further, artificial periosteum of the present utility model employs the design of double-layer porous layer, and more than the first of outer layer
The porosity of second porous layer 2 of the aperture layer 3 compared with the middle of is small.When being prepared using Biodegradable material, relatively existing individual layer
For loose and porous structure, the degradation time of the first relatively small porous layer 3 of outer layer porosity is longer, can more effectively consolidate
It is colonized bone material., can effectively and bone material and the second middle porous layer 2 is then similar to the structure of simple loose porous film
Osteanagenesis time match, three-decker membrane degradation time about 2-4 months on the whole, than simple loose porous membrane degradation time lengthening
1 times, effectively control degradation time.
In a preferred embodiment of the present utility model, the sandwich construction for being used for the artificial periosteum of hand Bone Defect Repari can
To be prepared using following methods：
First, Biodegradable material is configured to solution state, first casting film-forming is prepared in the form of solvent volatilizees
Cast layer 1.Preferably, molecular weight is dissolved in dichloromethane solvent for 150,000 PLA, is configured to PLA solution, takes scheduled volume molten
Liquid is placed in container, vacuumizes 8 hours, after the solvent is volatilized film forming.Or, the PLGA that molecular weight is 100,000 is dissolved in chloroform molten
In agent, PLGA solution is configured to, or molecular weight is dissolved in dioxane solvent for 200,000 PCL, PCL solution is configured to,
And use same method film forming.The curtain coating layer surface prepared using PLA, PLGA and PCL is smooth, and density is high, can effectively prevent
Only connective soft tissue is grown into.
Then, the solution that Biodegradable material is made is recorded on the surface of cast layer 1, is prepared by freeze-drying
The second middle porous layer 2.The freeze-drying step is specially：First pre-freeze (not the vacuumizing) at a temperature of -30~-20 DEG C
180min, then distillation (vacuumizing) is dried 48 hours at a temperature of -10~0 DEG C.Preferably, nanometer calcium microcosmic salt and collagen can be answered
The mineralized collagen powder of conjunction is dispersed in purified water and stirred 24~72 hours, formation mineralized collagen solution, wherein mineralized collagen
Concentration is 0.04-0.12g/ml.The second porous layer 2 can routinely be prepared using this area basic technology personnel in the utility model
Mineralized collagen material be made, for example by using following methods prepare mineralized collagen material：
Step S1, collagen is dissolved in any one of hydrochloric acid, nitric acid or acetic acid, is configured to the acid solution of collagen, wherein
Collagen concentration is 5.0 × 10-5-5.0×10-3g/mL；
Step S2, lasting whipping step S1 resulting solutions, are slowly added dropwise the solution of calcium ions, the addition of calcium ion is
Every gram of collagen correspondence adds calcium ion 0.01-0.16mol；
Step S3, lasting whipping step S2 resulting solutions, are slowly added dropwise the solution of phosphorus-containing acid ion, phosphate anion
The mol ratio of addition and calcium ion addition in step S2 is Ca/P=1/1-2/1；
Step S4, lasting whipping step S3 resulting solutions, are slowly added dropwise NaOH solution to mixed system pH=6-8, work as pH
During=5-6, mixed system starts to precipitate, as pH=7, and white suspension occurs in mixed system；
Step S5, mixed system obtained by step S4 stood 24-120 hour, isolate precipitation and wash away foreign ion, with
It is freeze-dried afterwards to constant weight.The freeze-drying step is specially：First pre-freeze (not the vacuumizing) at a temperature of -30~-20 DEG C
180min, then distillation (vacuumizing) is dried 48 hours at a temperature of -10~0 DEG C.
Step S6, will step S5 freeze-drying product grinding after sieve, filter out particle diameter<200 μm of mineralized collagen powder
Body is standby.
Finally, the solution that Biodegradable material is made is coated on the second porous layer 2, during now a small amount of solution can enter
Between the second porous layer 2.The freeze-drying step is specially：First pre-freeze (not the vacuumizing) at a temperature of -30~-20 DEG C
180min, then distillation (vacuumizing) is dried 48 hours at a temperature of -10~0 DEG C.Preferably, foregoing step can be weighed in the step
Mineralized collagen powder prepared by rapid S1-S6, and stirring 24~72 hours in purified water are dispersed in, mineralized collagen solution is formed, its
The concentration of middle mineralized collagen is 0.06-0.25g/ml.This area basic technology personnel can be by adjusting the concentration of mineralized collagen
Come the aperture needed for obtaining and porosity.
Referring to Fig. 2, dissecting schematic diagram for human body hand bone.As shown in Fig. 2 human body hand bone includes carpal bone, metacarpal bone and phalanges.
Wherein totally 5 pieces of metacarpal bone, I~V metacarpal bone 10 is followed successively by by the lateral ulnar side of oar.Totally 14 pieces of phalanges, thumb is two sections, and 2~5 refer to as three
Section, proximal phalanx 20, middle phalanx 30 and distal phalanx 40 are distad followed successively by by nearside.It is complicated due to hand bone, and
Clinical patients patient is more, in order that it is clinical in the reparation periosteum that uses can coincide periosteum defect shape, it is to avoid cut production
Raw waste, shape of the utility model also to the above-mentioned artificial periosteum for hand Bone Defect Repari is improved.
Referring to Fig. 3, being the shape of the artificial periosteum for hand Bone Defect Repari according to the utility model first embodiment
Schematic diagram.As shown in figure 3, the rectangular shape of the artificial periosteum, tiling or winding for metacarpal bone or Phalanx defect.The rectangle
The length L of artificial periosteum1For 20-120mm, width W1For 25-60mm, and in order to prevent from scratching tissue etc., the corner of rectangle is through falling
Fillet processing, the radius R of rounding1For 5-30mm.
Preferably, the artificial periosteum of the rectangle can be designed to different specifications according to different use positions：
1) when the artificial periosteum is the periosteum for the defect of I~V metacarpal bone 10, rectangle length L1For 60-120mm, width
W1For 25-60mm.
2) when the artificial periosteum is the periosteum for the defect of proximal phalanx 20, rectangle length L1For 30-80mm, width W1
For 25-60mm.
3) when the artificial periosteum is the periosteum for the defect of middle phalanx 30, rectangle length L1For 20-60mm, width W1
For 25-60mm.
4) when the artificial periosteum is the periosteum for the defect of distal phalanx 40, rectangle length L1For 10-40mm, width W1
For 25-60mm.
The length and width size of the artificial periosteum of above-mentioned rectangle is set for optimal size, can be applied to different parts
Bone defect healing, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, has saved substantial amounts of
The time of operation, while decreasing the waste of periosteum material.
Referring to Fig. 4, being the shape of the artificial periosteum for hand Bone Defect Repari according to the utility model second embodiment
Schematic diagram.As shown in figure 4, the artificial periosteum is in drops, including drops bottom and drops tip.Wherein, drops
Bottom is used for the tiling or winding of phalanges or metacarpal bone defect, and drops tip is then used for the tiling of phalanges or metacarpal bone defect.For example,
Drops tip is laid in phalanges upper surface, drops bottom is then wrapped on phalanges along the radian of phalanges.Preferably, water
The length L of drop-wise tip to drops bottom2For 10-120mm, the width W of drops bottom2For 25-60mm.
Preferably, the artificial periosteum of the drops can also be designed to different specifications according to different use positions：
1) when the artificial periosteum is the periosteum for the defect of I~V metacarpal bone 10, drops tip to drops bottom
Length is L2For 60-120mm, the width W of drops bottom2For 25-60mm.
2) when the artificial periosteum is the periosteum for the defect of proximal phalanx 20, the length at drops tip to drops bottom
Spend for L2For 30-80mm, the width W of drops bottom2For 25-60mm.
3) when the artificial periosteum is the periosteum for the defect of middle phalanx 30, the length at drops tip to drops bottom
Spend for L2For 20-60mm, the width W of drops bottom2For 25-60mm.
4) when the artificial periosteum is the periosteum for the defect of distal phalanx 40, the length at drops tip to drops bottom
Spend for L2For 10-40mm, the width W of drops bottom2For 25-60mm.
The size of the artificial periosteum of above-mentioned drops is set for optimal size, and the Cranial defect that can be applied to different parts is repaiied
It is multiple, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, saved substantial amounts of operation when
Between, while decreasing the waste of periosteum material.
Referring to Fig. 5, being the shape of the artificial periosteum for hand Bone Defect Repari according to the utility model 3rd embodiment
Schematic diagram.As shown in figure 5, the artificial periosteum is in convex, including convex portion 4 and convex bottom 5.Wherein, convex portion 4 be used for phalanges or
The tiling of metacarpal bone defect, convex bottom 5 is then used for the tiling or winding of phalanges or metacarpal bone defect.For example, convex portion 4 is laid in into finger
Bone upper surface, convex bottom 5 is then wrapped on phalanges along the radian of phalanges.Preferably, the width W of convex portion 43For 25-60mm,
The length L of convex bottom 5 is arrived in convex portion 43For 10-120mm, the length L of convex bottom 54For 5-60mm, and each rectangle of convex
Corner handled through rounding, the diameter R of rounding2For 5-30mm.
Preferably, the artificial periosteum of the convex can also be designed to different specifications according to different use positions：
1) when the artificial periosteum is the periosteum for the defect of I~V metacarpal bone 10, the width W of convex portion 43It is convex for 25-60mm
Portion 4 arrives the length L of convex bottom 53For 60-120mm, the length L of convex bottom 54For 20-60mm.
2) when the artificial periosteum is the periosteum for the defect of proximal phalanx 20, the width W of convex portion 43It is convex for 25-60mm
Portion 4 arrives the length L of convex bottom 53For 30-80mm, the length L of convex bottom 54For 20-60mm.
3) when the artificial periosteum is the periosteum for the defect of middle phalanx 30, the width W of convex portion 43It is convex for 25-60mm
Portion 4 arrives the length L of convex bottom 53For 20-60mm, the length L of convex bottom 54For 10-40mm.
4) when the artificial periosteum is the periosteum for the defect of distal phalanx 40, the width W of convex portion 43It is convex for 25-60mm
Portion 4 arrives the length L of convex bottom 53For 10-40mm, the length L of convex bottom 54For 5-30mm.
The size of the artificial periosteum of above-mentioned convex is set for optimal size, and the Cranial defect that can be applied to different parts is repaiied
It is multiple, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, saved substantial amounts of operation when
Between, while decreasing the waste of periosteum material.
With reference to embodiment, the utility model is described in further detail.If not otherwise specified, the utility model institute
Any scope recorded is including any numerical value between end value and end value and with any number between end value or end value
Any subrange constituted.
Raw material PLA (PLA) that each embodiment of the utility model is used, Poly(D,L-lactide-co-glycolide (PLGA) or
Polycaprolactone (PCL) is market purchase.Nanometer calcium microcosmic salt is synthesized with the mineralized collagen of collagen composite by aforementioned preparation process.
Embodiment 1
Artificial periosteum sequentially consists of the first porous layer that mineralized collagen is made, mineralized collagen is made second is porous
The cast layer that layer and PLA (PLA) are made.Wherein the first porous layer concentration is 0.25g/ml mineralized collagen solution system
Into average pore size is 50um, and porosity is 10%, and thickness is 0.02mm；Second porous layer concentration is 0.11g/ml ore deposit
Change collagen solution to be made, average pore size is 53um, and porosity is 55%, and thickness is 0.02mm；The thickness of cast layer is 0.01mm.
The rectangular shape of the artificial periosteum, length L1For 120mm, width W1For 60mm, for the flat of the defect of I~V metacarpal bone 10
Paving winds, and rounding processing, the radius R of rounding are done in the corner of rectangle1For 30mm.The artificial periosteum drops after implanting
The solution time is 2 months.
Embodiment 2
Artificial periosteum sequentially consists of the first porous layer that mineralized collagen is made, mineralized collagen is made second is porous
The cast layer that layer and Poly(D,L-lactide-co-glycolide (PLGA) are made.Wherein the first porous layer concentration is 0.06g/ml
Mineralized collagen solution be made, average pore size is 500um, and porosity is 28%, and thickness is 0.3mm；Second porous layer uses dense
Spend and be made up of 0.04g/ml mineralized collagen solution, average pore size is 355um, porosity is 95%, and thickness is 0.15mm；Curtain coating
The thickness of layer is 0.05mm.
The rectangular shape of the artificial periosteum, length L1For 60mm, width W1For 25mm, the tiling for the defect of proximal phalanx 20
Or winding, and rounding processing, the radius R of rounding are done in the corner of rectangle1For 20mm.The artificial periosteum is degraded after implanting
Time is 3 months.
Embodiment 3~12
Each parameters of film and implantation effect of embodiment 3~12 are as Table 1 and Table 2 below.
Comparative example 1~4
Each parameters of film and implantation effect of comparative example 1~4 are as Table 1 and Table 2 below.
Table 1
Table 2
Finally it should be noted that：Above example is only to illustrate the technical solution of the utility model, rather than its limitations；
Although the utility model is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：
It can still modify to the technical scheme described in foregoing embodiments, or which part technical characteristic is carried out etc.
With replacement；And these modifications or replacement, the essence of appropriate technical solution is departed from each embodiment technology of the utility model
The spirit and scope of scheme.
Claims (10)
1. a kind of artificial periosteum for hand Bone Defect Repari, it is characterised in that including：
First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50-500um, hole
Rate is 10-30%；
Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material, and flat
Equal aperture is 50-500um, and porosity is 50-95%；
Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material；
The rectangular shape of artificial periosteum, drops or the convex for hand Bone Defect Repari.
2. the artificial periosteum according to claim 1 for hand Bone Defect Repari, it is characterised in that the cast layer thickness is
0.01-0.05mm, first porous layer thickness is 0.02-0.3mm, and the thickness of second porous layer is 0.02-0.15mm.
3. the artificial periosteum according to claim 1 for hand Bone Defect Repari, it is characterised in that the cast layer is by poly- breast
Acid, Poly(D,L-lactide-co-glycolide or polycaprolactone are made；First porous layer and the second porous layer are by nanometer calcium microcosmic salt
It is made with the mineralized collagen of collagen composite.
4. the artificial periosteum for hand Bone Defect Repari according to any one of claim 1-3, it is characterised in that the people
The rectangular shape of work periosteum, length is 20-120mm, and width is 25-60mm, and the corner of rectangle is handled through rounding, rounding
Radius is 5-30mm.
5. the artificial periosteum according to claim 4 for hand Bone Defect Repari, it is characterised in that：The artificial periosteum is use
In the periosteum of metacarpal bone defect, and the rectangle length is 60-120mm；Or the artificial periosteum is for proximal phalanx defect
Periosteum, the rectangle length be 30-80mm；Or the artificial periosteum is periosteum for middle phalanx defect, and it is described
Rectangle length is 20-60mm；Or the artificial periosteum is for the periosteum for distal phalanx defect, and the rectangle length
10-40mm。
6. the artificial periosteum for hand Bone Defect Repari according to any one of claim 1-3, it is characterised in that the people
Work periosteum is in drops, includes the drops bottom of tiling or the winding for phalanges or metacarpal bone defect, and for phalanges or
The drops tip of the tiling of metacarpal bone defect；It is described and the length of drops tip to the drops bottom is 10-120mm
The width of drops bottom is 25-60mm.
7. the artificial periosteum according to claim 6 for hand Bone Defect Repari, it is characterised in that：The artificial periosteum is use
In the periosteum of metacarpal bone defect, and the sophisticated length to drops bottom of the drops is 60-120mm；Or the artificial bone
Film is the periosteum for proximal phalanx defect, and the length of drops tip to drops bottom is 30-80mm；Or institute
It is the periosteum for middle phalanx defect to state artificial periosteum, and the length of drops tip to drops bottom is 20-
60mm；Or the artificial periosteum is the periosteum for distal phalanx defect, and the drops is sophisticated to drops bottom
Length is 10-40mm.
8. the artificial periosteum for hand Bone Defect Repari according to any one of claim 1-3, it is characterised in that the people
Work periosteum is in convex, includes the convex portion of the tiling for phalanges or metacarpal bone defect, and the tiling for phalanges or metacarpal bone defect
Or the convex bottom of winding；The width of the convex portion is 25-60mm, and the length of the convex portion to convex bottom is 10-120mm,
The length of the convex bottom is 5-60mm.
9. the artificial periosteum according to claim 8 for hand Bone Defect Repari, it is characterised in that each square of the convex
The corner of shape is handled through rounding, and the radius of rounding is 5-30mm.
10. the artificial periosteum according to claim 9 for hand Bone Defect Repari, it is characterised in that：The artificial periosteum is
For the periosteum of metacarpal bone defect, and the length of the convex portion to convex bottom is 60-120mm, and the length of the convex bottom is
20-60mm；Or the artificial periosteum is to the length of convex bottom for the periosteum for proximal phalanx defect, and the convex portion
30-80mm, the length of the convex bottom is 20-60mm；Or the artificial periosteum is the periosteum for middle phalanx defect,
And the convex portion is 20-60mm to the length of convex bottom, the length of the convex bottom is 10-40mm；Or it is described artificial
Periosteum is periosteum for distal phalanx defect, and the convex portion to the length of convex bottom be 10-40mm, the convex bottom
Length be 5-30mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621128186.XU CN206518623U (en) | 2016-10-17 | 2016-10-17 | A kind of artificial periosteum for hand Bone Defect Repari |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621128186.XU CN206518623U (en) | 2016-10-17 | 2016-10-17 | A kind of artificial periosteum for hand Bone Defect Repari |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206518623U true CN206518623U (en) | 2017-09-26 |
Family
ID=59887943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621128186.XU Active CN206518623U (en) | 2016-10-17 | 2016-10-17 | A kind of artificial periosteum for hand Bone Defect Repari |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206518623U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113749826A (en) * | 2021-08-25 | 2021-12-07 | 西安交通大学 | Degradable sternocostal implant printed in 3D mode |
| CN118178054A (en) * | 2024-05-17 | 2024-06-14 | 中山大学 | Bone regeneration guiding bracket with hierarchical pore structure and preparation method and application thereof |
| JP7541718B2 (en) | 2020-08-19 | 2024-08-29 | 公立大学法人公立諏訪東京理科大学 | Bone treatment sheet and animal bone treatment method |
-
2016
- 2016-10-17 CN CN201621128186.XU patent/CN206518623U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7541718B2 (en) | 2020-08-19 | 2024-08-29 | 公立大学法人公立諏訪東京理科大学 | Bone treatment sheet and animal bone treatment method |
| CN113749826A (en) * | 2021-08-25 | 2021-12-07 | 西安交通大学 | Degradable sternocostal implant printed in 3D mode |
| CN118178054A (en) * | 2024-05-17 | 2024-06-14 | 中山大学 | Bone regeneration guiding bracket with hierarchical pore structure and preparation method and application thereof |
| CN118178054B (en) * | 2024-05-17 | 2024-08-06 | 中山大学 | Bone regeneration guiding bracket with hierarchical pore structure and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wang et al. | Collagen-based biomaterials for tissue engineering | |
| Lyons et al. | Nanostructured biomaterials for bone regeneration | |
| Zhu et al. | Bone regeneration with micro/nano hybrid-structured biphasic calcium phosphate bioceramics at segmental bone defect and the induced immunoregulation of MSCs | |
| Bhat et al. | Functionalized porous hydroxyapatite scaffolds for tissue engineering applications: a focused review | |
| Park et al. | Tissue engineering bone-ligament complexes using fiber-guiding scaffolds | |
| CN101141987B (en) | Medical material, artificial tooth root and method of producing material for clinical use | |
| EP2117617B1 (en) | A collagen/hydroxyapatite composite scaffold, and process for the production thereof | |
| Shi et al. | β-TCP scaffold coated with PCL as biodegradable materials for dental applications | |
| CN105903084A (en) | 3D printing porous scaffold with antibacterial functional coating and preparation method thereof | |
| DE102008044951A1 (en) | Open-pore biocompatible surface layer for an implant, method of manufacture and use | |
| CN108273131A (en) | A kind of composite bone cement, preparation method and applications and a kind of bone renovating material | |
| CN206518623U (en) | A kind of artificial periosteum for hand Bone Defect Repari | |
| CN103598919B (en) | A kind of preparation method of dental implant surface biological gradient coating | |
| Chen et al. | Multi-level customized 3D printing for autogenous implants in skull tissue engineering | |
| CN107185039A (en) | A kind of porous metals bone implant material and its preparation method and application | |
| CN110025409A (en) | A kind of elastic Invasive lumbar fusion device and preparation method thereof of magnesium powder function enhancing high molecular material porous structure | |
| CN107129157A (en) | A kind of preparation method of three-dimensional porous bioactivity glass | |
| CN204951735U (en) | Bionical organizational project of multilayer bone - cartilage biological activity support | |
| Uysal et al. | Comparison of the biological activities of high-density porous polyethylene implants and oxidized regenerated cellulose-wrapped diced cartilage grafts | |
| EP2897657B1 (en) | Hard scaffold | |
| CN110368524A (en) | A kind of bioactivity bone repairing support and preparation method thereof | |
| CN206518717U (en) | A kind of artificial periosteum for foot Bone Defect Repari | |
| DE10339953B3 (en) | Implant material for bone-cartilage replacement and its use | |
| Wilson Jr et al. | An initial assessment of the biocompatibility of crab shell for bone tissue engineering | |
| DE10006822A1 (en) | Artificial bone chips, processes for their production and their use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee after: Aojing Medical Technology Co., Ltd Address before: 100176 Beijing City, Daxing District Yizhuang Development Zone Sheng Road 1 homes aipuyi Building 1 Building 5 layer Patentee before: Beijing Allgens Medical Science and Technology Co.,Ltd. |
|
| CP03 | Change of name, title or address |