CN206518717U - A kind of artificial periosteum for foot Bone Defect Repari - Google Patents
A kind of artificial periosteum for foot Bone Defect Repari Download PDFInfo
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- CN206518717U CN206518717U CN201621129687.XU CN201621129687U CN206518717U CN 206518717 U CN206518717 U CN 206518717U CN 201621129687 U CN201621129687 U CN 201621129687U CN 206518717 U CN206518717 U CN 206518717U
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Abstract
The utility model is related to a kind of artificial periosteum for foot Bone Defect Repari, including：First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50 300um, and porosity is 10 30%；Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material, and average pore size is 200 500um, and porosity is 60 95%；Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material.Artificial periosteum of the present utility model has layer stereo structure, and the loose and porous structure of lower section is conducive to artificial periosteum to be fixed in autologous bone, is difficult to slip displacement；The smooth surface structure of top can effectively prevent connective soft tissue hyperplasia and grow into inside bone tissue, it is to avoid reduce the skeletonization space of bone tissue.
Description
Technical field
The utility model is related to technical field of medical instruments, more particularly to a kind of artificial periosteum for foot Bone Defect Repari.
Background technology
Fracture, bone nonunion, bone delay in healing etc. are clinically common orthopaedic diseases, except there is bone tissue defect, this
A little diseases are also directed to the defect of periosteum.Therefore, while bone defect healing is carried out, the defect of periosteum should also be repaiied
It is multiple, to reach more preferable clinical repair effect.However, there is presently no the artificial periosteum product for being available for Clinical practice.
Do not have special periosteum for repairing product clinically at present, some membranaceous implantation materials are used as replacing for periosteum
Generation and reparation, this kind of material mainly have acellular matrix film, degradable polymer film and collagem membrane etc..But these membranaceous implantation
Material is single layered porous structure, although Cranial defect face can be repaired, but also easily cause growing into for connective soft tissue,
Cause foot Bone Defect Repari effect not good.
Utility model content
The technical problems to be solved in the utility model is, is single layered porous structure for periosteum for repairing product in the prior art
Easily causing the problem of connective soft tissue is grown into, there is provided a kind of artificial periosteum for foot Bone Defect Repari.
In order to solve the above-mentioned technical problem, the utility model provides a kind of artificial periosteum for foot Bone Defect Repari, bag
Include：
First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50-300um,
Porosity is 10-30%；
Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material,
And average pore size is 200-500um, porosity is 60-95%；
Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material.
According in the artificial periosteum described in the utility model for foot Bone Defect Repari, the cast layer thickness is
0.01-0.05mm, first porous layer thickness is 0.02-0.3mm, and the thickness of second porous layer is 0.02-0.15mm.
According in the artificial periosteum described in the utility model for foot Bone Defect Repari, the cast layer by PLA,
Poly(D,L-lactide-co-glycolide or polycaprolactone are made；First porous layer and the second porous layer by nanometer calcium microcosmic salt with
The mineralized collagen of collagen composite is made.
According in the artificial periosteum described in the utility model for foot Bone Defect Repari, the artificial periosteum is for plantar
The periosteum of tiling or the winding of Cranial defect, the rectangular shape of artificial periosteum, length is 30-80mm, and width is 25-60mm, and
The corner of rectangle is handled through rounding, and the radius of rounding is 5-30mm.
According in the artificial periosteum described in the utility model for foot Bone Defect Repari, the artificial periosteum be for
The periosteum of tiling or the winding of Cranial defect, artificial periosteum is in ellipticity, and the oval major axis is 30-80mm, and short axle is 20-
60mm。
The artificial periosteum is the periosteum of tiling or the winding for the overall Cranial defect in arch area, and the artificial periosteum is in
The length of dumbbell shaped described in dumbbell shaped is 100-300mm, and width is 60-120mm.
Implement the artificial periosteum of the present utility model for foot Bone Defect Repari, have the advantages that：The utility model
Artificial periosteum there is layer stereo structure, the loose and porous structure of lower section is conducive to artificial periosteum to be consolidated in autologous bone
It is fixed, it is difficult to slip displacement；The smooth surface structure of top can effectively prevent connective soft tissue hyperplasia and grow into bone tissue
Portion, it is to avoid reduce the skeletonization space of bone tissue.In addition, the utility model is also improved by the shape to artificial periosteum, make
Its more identical periosteum defect shape, it is to avoid cut the waste produced, reduces patient suffering and medical expense.
Brief description of the drawings
Fig. 1 is to be illustrated according to the cross-section structure of the artificial periosteum for foot Bone Defect Repari of the utility model preferred embodiment
Figure；
Fig. 2 is the sufficient bone dissection schematic diagram of human body；
Fig. 3 is the schematic shapes of the artificial periosteum for foot Bone Defect Repari according to the utility model first embodiment；
Fig. 4 is the schematic shapes of the artificial periosteum for foot Bone Defect Repari according to the utility model second embodiment；
Fig. 5 is the schematic shapes of the artificial periosteum for foot Bone Defect Repari according to the utility model 3rd embodiment.
Embodiment
It is new below in conjunction with this practicality to make the purpose, technical scheme and advantage of the utility model embodiment clearer
Accompanying drawing in type embodiment, the technical scheme in the utility model embodiment is clearly and completely described, it is clear that retouched
The embodiment stated is a part of embodiment of the present utility model, rather than whole embodiments.Based on the reality in the utility model
Apply example, the every other embodiment that those of ordinary skill in the art are obtained on the premise of creative work is not made, all
Belong to the scope of the utility model protection.
Referring to Fig. 1, being the section of the artificial periosteum for foot Bone Defect Repari according to the utility model preferred embodiment
Structural representation.As shown in figure 1, the artificial periosteum for foot Bone Defect Repari that the embodiment is provided includes setting successively from bottom to up
The first porous layer 3, the second porous layer 2 and the cast layer 1 put.This is preferably for thickness of the artificial periosteum of foot Bone Defect Repari
0.05 arrives 0.5mm.
Wherein the first porous layer 3 is made up of Biodegradable material, and the average pore size of first porous layer 3 is 50-
300um, porosity is 10-30%.Preferably, first porous layer 3 by nanometer calcium microcosmic salt and collagen composite mineralized collagen system
Into, or be composited by nanometer calcium microcosmic salt and medical macromolecular materials.And the thickness of the first porous layer 3 is preferably 0.02-
0.3mm。
Second porous layer 2 is located on the first porous layer 3, and second porous layer can also be made up of Biodegradable material, and
Average pore size is 200-500um, and porosity is 60-95%.Preferably, second porous layer 2 is answered by nanometer calcium microcosmic salt and collagen
The mineralized collagen of conjunction is made, and the thickness of the second porous layer 2 is preferably 0.02-0.15mm.
Cast layer 1 is located on the second porous layer 2, and the cast layer is made up of Biodegradable material.Preferably, the cast layer
1 is made up of PLA (PLA), Poly(D,L-lactide-co-glycolide (PLGA) or polycaprolactone (PCL), and the thickness of cast layer 1
Preferably 0.01-0.05mm.
Artificial periosteum of the present utility model can enter in the operation of foot Bone Defect Repari to the bone defect healing region after bone grafting
Row cladding, reaches the purpose for substituting and rebuilding periosteum, the risk of reduction bone-grafting material abjection, and prevent the groups such as muscle, fat
Knit and be pressed into Cranial defect position, influence repairing effect.Specifically, artificial periosteum of the present utility model has layer stereo knot
Structure, artificial periosteum when for foot Bone Defect Repari, can be wound or be laid on the calcaneum of foot, metatarsal and arch area,
Now the first porous layer 3 is fitted with sufficient bone down, and its loose and porous structure is conducive to artificial periosteum to be fixed in autologous bone,
It is difficult to slip displacement；Meanwhile, cast layer 1 is contacted with connective soft tissue upward, and its smooth surface can effectively prevent connective
Soft tissue hyperplasia and grow into inside bone tissue, it is to avoid reduce bone tissue skeletonization space.
Further, artificial periosteum of the present utility model employs the design of double-layer porous layer, and more than the first of outer layer
The porosity of second porous layer 2 of the aperture layer 3 compared with the middle of is small.When being prepared using Biodegradable material, relatively existing individual layer
For loose and porous structure, the degradation time of the first relatively small porous layer 3 of outer layer porosity is longer, can more effectively consolidate
It is colonized bone material., can effectively and bone material and the second middle porous layer 2 is then similar to the structure of simple loose porous film
Osteanagenesis time match, three-decker membrane degradation time about 2-4 months on the whole, than simple loose porous membrane degradation time lengthening
1 times, effectively control degradation time.
In a preferred embodiment of the present utility model, the sandwich construction for being used for the artificial periosteum of foot Bone Defect Repari can
To be prepared using following methods：
First, Biodegradable material is configured to solution state, first casting film-forming is prepared in the form of solvent volatilizees
Cast layer 1.Preferably, molecular weight is dissolved in dichloromethane solvent for 150,000 PLA, is configured to PLA solution, takes scheduled volume molten
Liquid is placed in container, vacuumizes 8 hours, after the solvent is volatilized film forming.Or, the PLGA that molecular weight is 100,000 is dissolved in chloroform molten
In agent, PLGA solution is configured to, or molecular weight is dissolved in dioxane solvent for 200,000 PCL, PCL solution is configured to,
And use same method film forming.The curtain coating layer surface prepared using PLA, PLGA and PCL is smooth, and density is high, can effectively prevent
Only connective soft tissue is grown into.
Then, the solution that Biodegradable material is made is recorded on the surface of cast layer 1, is prepared by freeze-drying
The second middle porous layer 2.The freeze-drying step is specially：First pre-freeze (not the vacuumizing) at a temperature of -30~-20 DEG C
180min, then distillation (vacuumizing) is dried 48 hours at a temperature of -10~0 DEG C.Preferably, nanometer calcium microcosmic salt and collagen can be answered
The mineralized collagen powder of conjunction is dispersed in purified water and stirred 24~72 hours, formation mineralized collagen solution, wherein mineralized collagen
Concentration is 0.04-0.12g/ml.The second porous layer 2 can routinely be prepared using this area basic technology personnel in the utility model
Mineralized collagen material be made, for example by using following methods prepare mineralized collagen material：
Step S1, collagen is dissolved in any one of hydrochloric acid, nitric acid or acetic acid, is configured to the acid solution of collagen, wherein
Collagen concentration is 5.0 × 10-5-5.0×10-3g/mL；
Step S2, lasting whipping step S1 resulting solutions, are slowly added dropwise the solution of calcium ions, the addition of calcium ion is
Every gram of collagen correspondence adds calcium ion 0.01-0.16mol；
Step S3, lasting whipping step S2 resulting solutions, are slowly added dropwise the solution of phosphorus-containing acid ion, phosphate anion
The mol ratio of addition and calcium ion addition in step S2 is Ca/P=1/1-2/1；
Step S4, lasting whipping step S3 resulting solutions, are slowly added dropwise NaOH solution to mixed system pH=6-8, work as pH
During=5-6, mixed system starts to precipitate, as pH=7, and white suspension occurs in mixed system；
Step S5, mixed system obtained by step S4 stood 24-120 hour, isolate precipitation and wash away foreign ion, with
It is freeze-dried afterwards to constant weight.The freeze-drying step is specially：First pre-freeze (not the vacuumizing) at a temperature of -30~-20 DEG C
180min, then distillation (vacuumizing) is dried 48 hours at a temperature of -10~0 DEG C.Step S6, the freeze-drying product by step S5
Sieved after grinding, filter out particle diameter<200 μm of mineralized collagen powder is standby.
Finally, the solution that Biodegradable material is made is coated on the second porous layer 2, during now a small amount of solution can enter
Between the second porous layer 2, then implement freeze-drying can prepare the first porous layer 3 of outer layer.The freeze-drying step is specific
For：First pre-freeze (does not vacuumize) 180min at a temperature of -30~-20 DEG C, then distillation (vacuumizing) is done at a temperature of -10~0 DEG C
Dry 48 hours.Preferably, the mineralized collagen powder of abovementioned steps S1-S6 preparations can be weighed in the step, and is dispersed in purifying
Stirred 24~72 hours in water, form mineralized collagen solution, the wherein concentration of mineralized collagen is 0.06-0.25g/ml.This area
Basic technology personnel can be obtained by adjusting the concentration of mineralized collagen needed for aperture and porosity.Referring to Fig. 2, being people
Body foot bone dissection schematic diagram.As shown in Fig. 2 human body hand bone includes 7 pieces of shanks, 5 pieces of metatarsals and 14 pieces of phalanxes.The utility model
Artificial periosteum be mainly used in wherein metatarsal 10, the reparation of the overall Cranial defect of calcaneum 20 or arch area 30.Metatarsal 10 is by interior
Laterally outside is followed successively by 1-5 metatarsals.Calcaneum 20 is one piece maximum in seven pieces of shanks, positioned at sufficient rear lower, constitutes heel.Arch of foot
Position 30 is bonded by the arch of shank, metatarsal 10, and flexible and convergent force the tissue such as ligament, tendon in vola is total to
The bow of top is convex to one constituted.It is complicated due to sufficient bone, and clinical patients patient is more, in order that it is clinical in
The reparation periosteum used can coincide periosteum defect shape, it is to avoid cut the waste produced, and the utility model is also used for above-mentioned
The shape of the artificial periosteum of foot Bone Defect Repari is improved.
Referring to Fig. 3, being the shape of the artificial periosteum for foot Bone Defect Repari according to the utility model first embodiment
Schematic diagram.As shown in figure 3, the rectangular shape of the artificial periosteum, tiling or winding for the defect of metatarsal 10.Preferably, the rectangle
Artificial periosteum length L1For 30-80mm, width W1For 25-60mm, and in order to prevent from scratching tissue etc., the corner warp of rectangle
Rounding processing, the radius R of rounding1For 5-30mm.
The length and width size of the artificial periosteum of above-mentioned rectangle is set for optimal size, can be applied to the bone of metatarsal 10
Defect repair, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, has saved substantial amounts of hand
The time of art, while decreasing the waste of periosteum material.
Referring to Fig. 4, being the shape of the artificial periosteum for foot Bone Defect Repari according to the utility model second embodiment
Schematic diagram.As shown in figure 4, the artificial periosteum is in ellipticity, tiling or winding for the defect of calcaneum 20.Preferably, ellipticity
Longitudinal axis L2For 30-80mm, short axle W2For 20-60mm.
The size of above-mentioned elliptoid artificial periosteum is set for optimal size, and the Cranial defect that can be applied to calcaneum 20 is repaiied
It is multiple, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, saved substantial amounts of operation when
Between, while decreasing the waste of periosteum material.
Referring to Fig. 5, being the shape of the artificial periosteum for foot Bone Defect Repari according to the utility model 3rd embodiment
Schematic diagram.As shown in figure 5, the artificial periosteum is in dumbbell shaped, the bone for tiling or the winding of the overall Cranial defect in arch area 30
Film.Preferably, length L3For 100-300mm, the width W of dumbbell shaped3For 60-120mm.
The size of the artificial periosteum of above-mentioned dumbbell shaped is set for optimal size, can be applied to the Cranial defect of arch area 30
Repair, it is to avoid clinician goes to cut out because of the size and shape problem of periosteum when in use, has saved substantial amounts of operation
Time, while decreasing the waste of periosteum material.
With reference to embodiment, the utility model is described in further detail.If not otherwise specified, the utility model institute
Any scope recorded is including any numerical value between end value and end value and with any number between end value or end value
Any subrange constituted.
Raw material PLA (PLA) that each embodiment of the utility model is used, Poly(D,L-lactide-co-glycolide (PLGA) or
Polycaprolactone (PCL) is market purchase.Nanometer calcium microcosmic salt is synthesized with the mineralized collagen of collagen composite by aforementioned preparation process.
Embodiment 1
Artificial periosteum sequentially consists of the first porous layer that mineralized collagen is made, mineralized collagen is made second is porous
The cast layer that layer and PLA (PLA) are made, the first porous layer concentration is made up of 0.25g/ml mineralized collagen solution, puts down
Equal aperture is 50um, and porosity is 10%, and thickness is 0.02mm；Second porous layer concentration is 0.11g/ml mineralized collagen
Solution is made, and average pore size is 212um, and porosity is 60%, and thickness is 0.02mm；The thickness of cast layer is 0.01mm.
The rectangular shape of the artificial periosteum, length L1For 80mm, width W1For 60mm, for the defect of metatarsal 10 tiling or twine
Around, and rounding processing, the radius R of rounding are done in the corner of rectangle1For 30mm.Degradation time after the artificial periosteum implants
For 2 months.
Embodiment 2
Artificial periosteum sequentially consists of the first porous layer that mineralized collagen is made, mineralized collagen is made second is porous
The cast layer that layer and Poly(D,L-lactide-co-glycolide (PLGA) are made.Wherein the first porous layer concentration is 0.06g/ml
Mineralized collagen solution be made, average pore size be 300um, porosity is 29%, and thickness is 0.3mm；Second porous layer is used
Concentration is made up of 0.04g/ml mineralized collagen solution, and average pore size is 378um, and porosity is 95%, and thickness is 0.15mm；Stream
The thickness for prolonging layer is 0.05mm.
The rectangular shape of the artificial periosteum, length L1For 60mm, width W1For 25mm, for the tiling or winding of metatarsal defect,
And rounding processing, the radius R of rounding are done in the corner of rectangle1For 20mm.Degradation time is 3 after the artificial periosteum implants
Individual month.
Embodiment 3~12
Each parameters of film and implantation effect of embodiment 3~12 are as Table 1 and Table 2 below.
Comparative example 1~4
Each parameters of film and implantation effect of comparative example 1~4 are as Table 1 and Table 2 below.
Table 1
Table 2
Finally it should be noted that：Above example is only to illustrate the technical solution of the utility model, rather than its limitations；
Although the utility model is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：
It can still modify to the technical scheme described in foregoing embodiments, or which part technical characteristic is carried out etc.
With replacement；And these modifications or replacement, the essence of appropriate technical solution is departed from each embodiment technology of the utility model
The spirit and scope of scheme.
Claims (5)
1. a kind of artificial periosteum for foot Bone Defect Repari, it is characterised in that including：
First porous layer, is made up of Biodegradable material, and the average pore size of first porous layer is 50-300um, hole
Rate is 10-30%；
Second porous layer, it is located on first porous layer, and second porous layer is made up of Biodegradable material, and flat
Equal aperture is 200-500um, and porosity is 60-95%；
Cast layer, it is located on second porous layer, and the cast layer is made up of Biodegradable material；
The artificial periosteum for foot Bone Defect Repari is in ellipticity or dumbbell shaped.
2. the artificial periosteum according to claim 1 for foot Bone Defect Repari, it is characterised in that the cast layer thickness is
0.01-0.05mm, first porous layer thickness is 0.02-0.3mm, and the thickness of second porous layer is 0.02-0.15mm.
3. the artificial periosteum according to claim 1 for foot Bone Defect Repari, it is characterised in that the cast layer is by poly- breast
Acid, Poly(D,L-lactide-co-glycolide or polycaprolactone are made；First porous layer and the second porous layer are by nanometer calcium microcosmic salt
It is made with the mineralized collagen of collagen composite.
4. the artificial periosteum for foot Bone Defect Repari according to any one of claim 1-3, it is characterised in that the people
Work periosteum is that, for the tiling with Cranial defect or the periosteum of winding, the artificial periosteum is in ellipticity, the oval major axis
For 30-80mm, short axle is 20-60mm.
5. the artificial periosteum for foot Bone Defect Repari according to any one of claim 1-3, it is characterised in that the people
Work periosteum is the periosteum of tiling or the winding for the overall Cranial defect in arch area, and the artificial periosteum is in dumbbell shaped, described mute
The length of bell-shaped is 100-300mm, and width is 60-120mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621129687.XU CN206518717U (en) | 2016-10-17 | 2016-10-17 | A kind of artificial periosteum for foot Bone Defect Repari |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621129687.XU CN206518717U (en) | 2016-10-17 | 2016-10-17 | A kind of artificial periosteum for foot Bone Defect Repari |
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| CN206518717U true CN206518717U (en) | 2017-09-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171496A (en) * | 2021-05-14 | 2021-07-27 | 中国人民解放军空军军医大学 | Porous PCL/collagen artificial periosteum with oriented drug sustained release function and preparation method thereof |
-
2016
- 2016-10-17 CN CN201621129687.XU patent/CN206518717U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171496A (en) * | 2021-05-14 | 2021-07-27 | 中国人民解放军空军军医大学 | Porous PCL/collagen artificial periosteum with oriented drug sustained release function and preparation method thereof |
| CN113171496B (en) * | 2021-05-14 | 2022-03-01 | 中国人民解放军空军军医大学 | Porous PCL/collagen artificial periosteum with oriented drug sustained release function and preparation method thereof |
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Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee after: Aojing Medical Technology Co., Ltd Address before: 100176 Beijing City, Daxing District Yizhuang Development Zone Sheng Road 1 homes aipuyi Building 1 Building 5 layer Patentee before: Beijing Allgens Medical Science and Technology Co.,Ltd. |