CN106214790A - A kind of blood-eating hirudo prescription drug, ointment and application thereof for treating hemorrhoid - Google Patents
A kind of blood-eating hirudo prescription drug, ointment and application thereof for treating hemorrhoid Download PDFInfo
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- CN106214790A CN106214790A CN201610755252.4A CN201610755252A CN106214790A CN 106214790 A CN106214790 A CN 106214790A CN 201610755252 A CN201610755252 A CN 201610755252A CN 106214790 A CN106214790 A CN 106214790A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Insects & Arthropods (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of with blood-eating hirudo prescription drug.Described prescription drug is made up of blood-eating hirudo, Radix Sanguisorbae and gallic crude drug or extract.The wherein salty hardship of blood-eating hirudo, flat, traumatic blood stasis is had a pain and has good curative effect.Galla Chinensis has pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore.The acid of Radix Sanguisorbae bitter in the mouth, nontoxic；Return liver, lung, kidney and large intestine channel；There are cooling blood for hemostasis, heat-clearing and toxic substances removing, train the effects such as clear yin nourishing, detumescence sore.We are aided with Radix Sanguisorbae Galla Chinensis with blood-eating hirudo for monarch；Play the silt pain relieving that disappears, the merit of removing heat from blood convergence altogether.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula medicine, a kind of blood-eating hirudo for treating hemorrhoid is joined
Side's medicine, ointment and application thereof.
Technical background
Blood-eating hirudo (formal name used at school: Hirudo nipponia) be Yi Zhi section doctor trematodiasis belong to animal, popular name hirudo nipponica, Hirudo,
Line Hirudo, Hirudo, Japan doctor Hirudo.Be distributed in the Far East Area Japanese, Muscovite, Mongolia and China's Mainland North gets northeast
Each province, the Inner Mongol, west to Sichuan, Gansu, south reach the ground such as Guangdong, typically inhabit paddy field and the irrigation canals and ditches communicated therewith, pond
Most with quantity in hydrops in marsh and particularly throughout the year or the waterlogged plot of impeded drainage and field heart.Described in Materia Medica of Decoction
Blood-eating hirudo, hardship walks blood, salty victory blood, and Zhong Jing Didang Tang is with Tabanus, blood-eating hirudo, and salty hardship is to let out poultry blood, therefore " warp " cloud has former nothing
Die also.Blood-eating hirudo described in " Bencao Jingshu ": salty in the mouth hardship gas is put down, and very toxic, it is with similar to Tabanus, therefore in Zhong Jingfang often
Therewith and execute.Salty enter blood walk blood, hardship lets out knot, and salty hardship is parallel, thus control married woman's stagnant blood, blood stasis, close by the moon, abdominal mass due to blood stasis gathers, thus loss of fecundity
Person.Blood poultry bladder, then water channel is obstructed, and blood dissipates and duty that bladder must gasify, and water channel does not seek its profit and diarrhea.Abortionist, with tool
Poisonous kind removing blood stasis is also.Blood-eating hirudo described in " book on Chinese herbal medicine converge with speech ": by stagnant blood, blood stasis medicine also.Fang Longtan says, by " property of medicine opinion "
Speech, this medicine row poultry blood, mass formed by blood stasis, accumulation, kind to control woman and close loss of fecundity the moon and form emaciation due to blood disorder person, this all blood stays and stagnant, and conception vessel is obstructed, the moon
Thing is not with loss of fecundity at present.Irregular menstrual cycle, and be to stop up as the stasis of blood, gradually become heat, for coughing, for yellow, for thin, this blood stasis consumptive disease one-tenth
?.Adjusting its punching to appoint, ward off to form and be pregnent, blood is logical and consumptive disease is gone.Therefore Zhong Jing side enter Radix Et Rhizoma Rhei et Eupolyphaga Seu Steleophaga Pilulae and control blood stasis, hectic fever due to YIN-deficiency, squamous and dry skin,
Cough into labor person；Enter biejiajian pills and control chronic malaria malaria with splenomegaly, cold and heat yellowish complexion, abdominal distention and like labor person；Enter Didang Tang, ball and cure the wound cold little
Abdomen whip is full, normal urination, go mad and belong to poultry blood disorder person.Blood-eating hirudo described in " book on Chinese herbal medicine is through hundred kinds of records ": ordinary person's body blood stasis sheet resistance,
Still Animando person easily controls, as long as resistance, then and lackluster and refractory.Lid blood both from warp, belonged to healthy energy entirely mutually, the light medicine of throwing, then refuse
And do not receive, medicine is the highest, instead can hinder again the blood not lost, thus control extremely difficult.The blood of blood-eating hirudo eating people, and property is slow kind
Entering, slow, hemopoietic is not hindered, and is apt to into then hard long-pending fragile, by means of its power to attack accumulate in the course of time stagnant, from favourable and harmless also.
Radix Sanguisorbae (Classification system: Sanguisorba officinalis L.) is that Rosaceae burnet perennial herb is planted
Thing, Radix Sanguisorbae is also Chinese herbal medicine.Cold in nature, bitter in the mouth acid, nontoxic；Return liver, lung, kidney and large intestine channel.There are cooling blood for hemostasis, heat-clearing and toxic substances removing, training
Clear yin nourishing, the effect such as detumescence sore.
Galla Chinensis, Chinese medicine name.For Anacardiaceae plant Fructus rhois chinensis Rhus chinensis Mill. potanin sumac Rhus
Potaninii Maxim. or Radix Rhois Sinicae Rhus punjabensis Stew.var.sinica (Diels) Rehd.et Wils.
Insect gall on leaf, is mainly formed by melaphis chinensis Baker Melaphis chinensis (Bell) Baker parasitism.There is fall of astringing the lung
Fire, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore.Being usually used in chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous perspiration is stolen
Antiperspirant, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, with vein under anal canal skin under Skin wet and rotten human rectum's end mucosa
The soft vein group that the raw expansion of burst and flexing are formed, referred to as hemorrhoid, have another name called hemorrhoid, blood stasis, hemorrhoid disease, haemorrhoids etc..
Medical science indication hemorrhoid include internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, are bottom anal orifice and rectal intestine and the generation of the venous plexus of anal mucosa
A kind of chronic disease of the vein group of varicose and one or more softnesses of being formed.Hemorrhoid are dragged for a long time and are not controlled, and blood stasis can be caused to take off
Go out to form incarceration, aggravate the pain and the state of an illness, secondly anal infection, once form bleeding hemorrhoids symptom, antibacterial, toxin, purulent core pole
Easily invade blood and cause pyaemia septica etc..Additionally due to the abjection of hemorrhoid block causes sphincter dilatation, mucus flows out outside anus long-term
Stimulate surrounding skin, be easily caused pruritus and skin eczema.Hemorrhoid may result in human body anemia, internal hemorrhoid abjection, hepatic portal tissue necrosis and
Infect.The pharmaceutical dosage form for the treatment of hemorrhoid mainly directly applies to the suppository of lesions position (anorectal), unguentum and is used for pasting umbilicus
Patch, and oral medication etc..Existing hemorrhoid treating method mainly has: 1, Chinese medicine: as used Ma Yinglong Moschus hemorrhoid
Skin ulcer bolt, MAYINGLONG MUSK HEMORRHOID UNGUENTUM, diosmin sheet, hemorrhoid inflammation school sheet etc.；2, therapeutic method of surgery, it is simply that extract blood stasis or with stitching
The mechanical means such as bundle make thromboembolism or wither.But operation method is relatively big for patient suffering, simultaneously need to postoperative mastery, unfavorable
Working and learning in patient.
Summary of the invention
This is for solving the problems referred to above, the invention provides a kind of with blood-eating hirudo prescription drug.The wherein salty hardship of blood-eating hirudo,
Flat, traumatic blood stasis is had a pain and has good curative effect.Galla Chinensis has pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, removing dampness sore
Effect.The acid of Radix Sanguisorbae bitter in the mouth, nontoxic；Return liver, lung, kidney and large intestine channel；Having cooling blood for hemostasis, heat-clearing and toxic substances removing, train clear yin nourishing, detumescence is held back
The effects such as skin ulcer.We are aided with Radix Sanguisorbae Galla Chinensis with blood-eating hirudo for monarch；Play the silt pain relieving that disappears, the merit of removing heat from blood convergence altogether.Specifically
Technical scheme be: described prescription drug is made up of blood-eating hirudo, Radix Sanguisorbae and gallic crude drug or extract.
Described prescription drug is carried by the ultra-micro powder of blood-eating hirudo medical material, the ethanol extraction of Radix Sanguisorbae and gallic ethanol
Take thing composition.
Described blood-eating hirudo ultra-micro powder is for using wine processing blood-eating hirudo medical material or wine processing blood-eating hirudo medical material system
For obtaining.
Described blood-eating hirudo, Radix Sanguisorbae and gallic weight ratio are 1-10:1-10:1-10.
Described blood-eating hirudo, Radix Sanguisorbae and gallic weight ratio are 3:2:2.
Described blood-eating hirudo prescription drug ointment, described blood-eating hirudo prescription drug, stearic acid, liquid paraffin and three
The weight ratio of ethanolamine composition is 7:14:6:1.
The preparation method of a kind of blood-eating hirudo prescription drug ointment, comprises the following steps:
1) medical material is weighed according to ratio described in any one of claim 1-5, by blood-eating hirudo micronizing, Radix Sanguisorbae and five times
Son adds 60% alcohol reflux 2 times of medical material weight 3 times；
2) filter Radix Sanguisorbae and Galla Chinensis ethanol extract, merge, reclaim ethanol, be concentrated into the sticky original text that density is 1.2, mixed
Enter blood-eating hirudo superfine powder and obtain blood-eating hirudo prescription drug；
4) weigh stearic acid, liquid paraffin and three ethanol in proportion, heat miscible after, be blended into blood-eating hirudo magistral medicines
Thing, the most fully emulsified with magnetic stirrer at 70-80 DEG C, it is cooled to room temperature and i.e. obtains the ointment of blood-eating hirudo prescription drug
Agent.
The application in the medicine of preparation treatment hemorrhoid of the described ointment.
The method have the benefit that: the Chinese prescription medicine of the treatment hemorrhoid that the invention provides, in treatment hemorrhoid
Skin ulcer aspect has good technique effect.
Detailed description of the invention
Embodiment 1 is for the preparation of reagent thing
1, the process of preparing Chinese medicine of blood-eating hirudo
1. weigh dry blood-eating hirudo medical material 200g, after being made popular by river sand, put into blood-eating hirudo medical material, parch blood-eating hirudo
Bubble, the sieve grains of sand to the greatest extent, add containing acetic acid 5-7% vinegar 100ml, inhale thoroughly, dry, obtain vinegar blood-eating hirudo.
2. weigh dry blood-eating hirudo medical material 200g, soak with yellow wine 100ml, put in pot, simmer in water to wine quilt
Fully absorb, dry, obtain processed with wine blood-eating hirudo.
3. weigh dry blood-eating hirudo medical material 200g, mix with 100ml18-20% yellow wine, with low baking temperature parch faint yellow its
Bubbling, obtains wine processing blood-eating hirudo.
2, blood-eating hirudo prescription drug and the preparation of matched group medicine
1. Galla Chinensis 100g, Radix Sanguisorbae 100g, vinegar blood-eating hirudo 150g are weighed, by vinegar blood-eating hirudo micronizing to grain
Footpath is less than the powder of 40 μm；Pulverizing Radix Sanguisorbae and become coarse powder with Galla Chinensis, mixing, with 60% alcohol reflux 2 of medical material weight 3 times
Secondary, each 45min；Filter Radix Sanguisorbae and Galla Chinensis ethanol extract, merge, reclaim ethanol, be concentrated into density be 1.2 sticky
Original text, is mixed into blood-eating hirudo superfine powder and obtains blood-eating hirudo prescription drug；By stearic acid: the weight of (liquid paraffin+triethanolamine)
Than the proportional arrangement substrate for 2:1, wherein liquid paraffin: the weight ratio of triethanolamine is 6:1；By extractum: matrix weight compares 1:3
Principal agent is added extractum, the most fully emulsified with magnetic stirrer at 70-80 DEG C, it is cooled to room temperature and get final product；Prepare reality
Test group I.
2. weigh Galla Chinensis 100g, Radix Sanguisorbae 100g, wine processing blood-eating hirudo 150g, use above-mentioned side to prepare experiment
Group II.
3. III weigh Galla Chinensis 100g, Radix Sanguisorbae 100g, wine processing blood-eating hirudo 150g, use above-mentioned side to prepare reality
Test group.
4. weighing wine processing blood-eating hirudo 400g, micropowder is broken to the particle diameter powder less than 40 μm；By stearic acid: (liquid
Paraffin+triethanolamine) the proportional arrangement substrate that weight ratio is 2:1, wherein liquid paraffin: the weight ratio of triethanolamine is 6:1；
By extractum: principal agent is added extractum than 1:3 by matrix weight, the most fully emulsified with magnetic stirrer at 70-80 DEG C, is cooled to
Room temperature and get final product；Said method is used to prepare blood-eating hirudo group.
The investigation of embodiment 2 formulation conditions
Weigh blood-eating hirudo and each 100g of Radix Sanguisorbae, be placed in the round-bottomed flask of 2000mL.Add the soak by water of medical material weight 5 times
Twice, each 1h；Filter；Merge medicinal liquid, be concentrated into 1:2, add ethanol and make its alcohol content reach 75%, carry out at precipitate with ethanol
Reason.Filter after cold preservation 24h, reclaim ethanol.Concentration of liquid medicine is made to arrive thick extractum, refrigerated storage after waving most alcohol taste.Standby.
As shown in table 1, after miscible for substrate.Add principal agent extractum, 70-80 DEG C with magnetic stirrer to fully breast
Change, be cooled to room temperature and get final product.
Determine factor level: using extractum, stearic acid, liquid paraffin, triethanolamine as the factor of investigation, each factor selects 3
Individual level, selects L9(34) orthogonal table test, factor level is shown in Table 1, and orthogonal experiments is shown in Table 2.
Evaluation index: use the quality comprehensively commenting part method to evaluate made ointment, with heat-resisting.Tolerance to cold, stretchability, release
Speed is that factor calculates as evaluation index, employing weighted scoring, and it is heat-resisting, tolerance to cold (F1).Stretchability (F2), release
It is 0.2,0.2,0.6 that the weight coefficient of speed (F3) respectively provides.
(1) heat-resisting, tolerance to cold F1: the ointment installed is placed 6h and-15 DEG C of isoperibols in 55 DEG C of thermostatic drying chambers, puts
Put 24h, observe with or without oil-water separation.If it is stable.Anhydrous separating of oil person is 20 points；If having part water separating of oil is 10 points；If water
Oil is completely separated into 0 point.
(2) stretchability F2: take appropriate sample, carefully smears at the palm back of the body.Relatively it sprawls ease, observes and smears rear skin
Oiliness.If having good stretchability is that 2O divides, preferable stretchability is 10 points, and the stretchability of difference is 0 point.
(3) drug release rate F3: use agar method for releasing.With agar gel as dispersive medium, ointment is coated in containing referring to
Show that close contact on the agar surface of agent, height flush with test tube mouth.Upright placement after completing, after placing 24h.Observe and measure
Height in zone.The chromatograph height produced by measuring medicine and indicator carrys out the speed that comparative drug discharges from substrate.
Drug release rate weighted scoring=(60/ the highest chromatograph height) × a certain chromatograph height.
Table 1 factor level
Table 2 preparation prescription Orthogonal experiment results
Interpretation of result: each factor is C > B > A on the order that affects of ointment making technique, and only factor B, C have notable
Property.Consider, determine that optimum extraction process is: A2B1C2, i.e. extractum: substrate=1:3, stearic acid: (liquid paraffin+three ethanol
Amine)=2:1, liquid paraffin: triethanolamine=6:1.
The active function of hemorrhoid is investigated by embodiment 3 blood-eating hirudo prescription drug ointment
Analgesic experiment takes body weight (20 ± 2) g female mice, and 70 altogether, before experiment, fasting can't help water 12h, with thermostatted water
In the range of bath heating aluminum barrel makes its temperature be maintained at (55 ± 0.5) DEG C, put test mice at the bottom of cylinder, timing immediately, go out with mice
Now kicking, licking metapedes is its pain reaction index, and stopping timing is its pain threshold.Select the threshold of pain in advance little in 10 seconds～20 seconds
Mus, tie-in 2 times, take its average as value before medicine.Qualified mice is divided into 8 groups at random, and i.e. distilled water matched group, uses embodiment
The group I arrived in 2, II, III, blood-eating hirudo group, commercially available MAYINGLONGZHICHUANGGAO group and positive drug dolantin matched group.Tested
Medicine is configured to the suspension per anum gavage syringe needle of 10% concentration respectively and medicine or distilled water is directly injected into rectum with distilled water
(volume is 0.2mL/1Og body weight), and clamp anus in case overflow of drug fluid with special little folder, take off after 1h, every day 1 time, give continuously
Medicine 3d (dolantin treated animal SC the most on pretreatment is administered once).Last is pressed preceding method and is surveyed each treated animal pain threshold after being administered.
Before and after relatively each treated animal is administered, threshold of pain change carries out statistical analysis with t inspection.The results are shown in Table shown in 3.
Table 3 blood-eating hirudo prescription drug ointment causes the impact in mice threshold of pain response time to hot plate method
Note: compare with before medicine, < O.05, * * P is < O.01 for * P
On mice by the impact of ear inflammation caused by dimethylbenzene, take (20 ± 2) g healthy male mice 96, be randomly divided into
Distilled water matched group, the group I arrived in embodiment 2, II, III, blood-eating hirudo group, commercially available MAYINGLONGZHICHUANGGAO group, medication
Method is the same, successive administration 5d, 1h after last administration, smears dimethylbenzene 0.05mL in mice left ear positive and negative and causes inflammation.After 15min
Putting to death mice, take off a disk with diameter 9mm card punch at the same position of mice two ear, precise weighing, with two auricle difference table
Showing swelling, calculate its suppression ratio, observe each treated animal to swelling and the impact of suppression ratio, t inspection between organizing, result is shown in
Shown in table 4.
Table 4 blood-eating hirudo prescription drug ointment on mice by the impact of ear inflammation caused by dimethylbenzene
Note: compare with matched group.*P<0.01
Impact on mice clotting time and bleeding time takes mice 80 about body weight 24g, male and female half and half, is randomly divided into 8 groups, at random
It is divided into distilled water matched group, the group I arrived in embodiment 2, II, III, blood-eating hirudo group, commercially available MAYINGLONGZHICHUANGGAO group,
Administrated method is the same, successive administration 3d, 1h after the most secondary administration, makes its blood certainly blocking with blade at Mouse Tail-tip 1.0cm
So flow out and start timing.After l5min every the l5 second with filter paper gentle aspiration tail point once, to when being designated as hemorrhage time the most hemorrhage
Between；After docking, take one immediately bleed and be placed on clean microscope slide, timing immediately, every 15 seconds with sharp spike gently simultaneously
Provoking once, to occur that the blood streak is its clotting time, result all represents with (± s), and carry out group ask compare t inspection, result is shown in
Shown in table 5.
Table 5 blood-eating hirudo prescription drug ointment is hemorrhage on mice, the impact of clotting time
Note: compare .*P < 0.01 with matched group
Impact on normal mouse defecation time takes healthy hungry 24h mice 80, male and female half and half, is randomly divided into 8 groups.For
The group I arrived in blank group, embodiment 2, II, III, blood-eating hirudo group, commercially available MAYINGLONGZHICHUANGGAO group, with India
Prepared Chinese ink is mark, will be mixed in 5% arabic gum suspension (matched group) or 5%, 10% tested medicinal liquid by mark, presses
0.2mL/10g gastric infusion, is then placed in mice list cage in the cage being lined with white filter paper, and timing immediately, to discharge first
Melena containing prepared Chinese ink is its defecation time；Represent with (± 1).Relatively medication group and the difference compareed, the results are shown in Table shown in 6.
Table 6 blood-eating hirudo prescription drug ointment is hemorrhage on mice, the impact of clotting time
Note: compare with matched group,*P<O.05。
Knowable to the data of table 3-6, blood-eating hirudo prescription drug ointment is caused due to physical stimulation (hot plate method) to mice
Pain reaction have good inhibiting effect, effect is similar to MAYINGLONGZHICHUANGGAO；Show that this medical instrument has certain analgesic effect.
Mice is increased by the permeability of the auricular concha swelling caused by dimethylbenzene and abdominal cavity blood capillary and also has obvious inhibitory action, effect
Slightly it is better than MAYINGLONGZHICHUANGGAO, it is believed that blood-eating hirudo prescription drug ointment has the suppression inflammation work that Inflammatory substances oozes out in early days
With.Meanwhile, blood-eating hirudo prescription drug ointment is better than MAYINGLONGZHICHUANGGAO improving on defecation.Meanwhile, by contrast experiment's group
I, II, III, find the prescription drug using the blood-eating hirudo of wine processing to make, activity is best；Next to that use yellow wine brewed
Blood-eating hirudo；And use the blood-eating hirudo clinical efficacy of vinegar worst.Brewed blood-eating hirudo under conditions of alkalescence is described
Can preferably strengthen the activity of blood-eating hirudo medical material.
Claims (8)
1. one kind for treating the blood-eating hirudo prescription drug of hemorrhoid, it is characterised in that: described prescription drug by blood-eating hirudo,
Elm and gallic crude drug or extract form.
Blood-eating hirudo prescription drug for treating hemorrhoid the most according to claim 1, it is characterised in that: described magistral medicines
Thing is made up of the ultra-micro powder of blood-eating hirudo medical material, the ethanol extraction of Radix Sanguisorbae and gallic ethanol extraction.
Blood-eating hirudo prescription drug for treating hemorrhoid the most according to claim 2, it is characterised in that: described Japan doctor
Trematodiasis ultra-micro powder is for prepare with wine processing blood-eating hirudo medical material or wine processing blood-eating hirudo medical material.
Blood-eating hirudo prescription drug for treating hemorrhoid the most according to claim 3, it is characterised in that: described Japan doctor
Trematodiasis, Radix Sanguisorbae and gallic weight ratio are 1-10:1-10:1-10.
Blood-eating hirudo prescription drug for treating hemorrhoid the most according to claim 4, it is characterised in that: described Japan
Doctor trematodiasis, Radix Sanguisorbae and gallic weight ratio are 3:2:2.
Blood-eating hirudo prescription drug ointment the most according to claim 4, it is characterised in that: described blood-eating hirudo magistral medicines
The weight ratio of thing, stearic acid, liquid paraffin and triethanolamine composition is 7:14:6:1.
7. the preparation method of a blood-eating hirudo prescription drug ointment, it is characterised in that: comprise the following steps:
1) weigh medical material according to ratio described in any one of claim 1-5, blood-eating hirudo micronizing, Radix Sanguisorbae and Galla Chinensis are added
60% alcohol reflux of medical material weight 3 times 2 times；
2) filter Radix Sanguisorbae and Galla Chinensis ethanol extract, merge, reclaim ethanol, be concentrated into the sticky original text that density is 1.2, be mixed into day
This doctor trematodiasis superfine powder obtains blood-eating hirudo prescription drug；
4) weigh stearic acid, liquid paraffin and three ethanol in proportion, heat miscible after, be blended into blood-eating hirudo prescription drug,
70-80 DEG C the most fully emulsified with magnetic stirrer, is cooled to room temperature and i.e. obtains the ointment of blood-eating hirudo prescription drug.
8. the application in the medicine of preparation treatment hemorrhoid of the ointment described in claim 6.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110850A (en) * | 2012-12-11 | 2013-05-22 | 陈文中 | Ointment for treating haememorrhoids |
| CN103565958A (en) * | 2013-10-22 | 2014-02-12 | 重庆市中药研究院 | Folium isatidis and coptidis rhizoma drug pair combined medicament, ointment and application thereof |
| CN105687390A (en) * | 2014-11-27 | 2016-06-22 | 蔡卫进 | Externally applied traditional Chinese medicine formula for treatment of blood stasis type hemorrhoids |
-
2016
- 2016-08-29 CN CN201610755252.4A patent/CN106214790A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110850A (en) * | 2012-12-11 | 2013-05-22 | 陈文中 | Ointment for treating haememorrhoids |
| CN103565958A (en) * | 2013-10-22 | 2014-02-12 | 重庆市中药研究院 | Folium isatidis and coptidis rhizoma drug pair combined medicament, ointment and application thereof |
| CN105687390A (en) * | 2014-11-27 | 2016-06-22 | 蔡卫进 | Externally applied traditional Chinese medicine formula for treatment of blood stasis type hemorrhoids |
Non-Patent Citations (1)
| Title |
|---|
| 冉懋雄等: "《现代中药炮制手册》", 31 January 2002, 中国中医出版社 * |
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