CN103721095A

CN103721095A - Traditional Chinese medicine preparation for preventing influenza

Info

Publication number: CN103721095A
Application number: CN201310504082.9A
Authority: CN
Inventors: 韩秀英
Original assignee: Qingdao Huaren Technology Incubator Co Ltd
Current assignee: Shantou Olive Branch Pharmaceutical Co ltd
Priority date: 2013-10-23
Filing date: 2013-10-23
Publication date: 2014-04-16
Anticipated expiration: 2033-10-23
Also published as: CN103721095B

Abstract

The invention provides a traditional Chinese medicine for preventing influenza. The traditional Chinese medicine comprises crude drugs such as folium isatidis, subprostrate sophora, herba elsholtziae, aleppo avens, platycodon grandiflorum, abrus cantoniensis hance, artemisia apiacea, ginseng leaves, radix angelicae, rhizoma anemarrhenae, manyleaf paris rhizome, burdock, cloves, groundsel, lalang grass rhizome, rhizoma dryopteris crassirhizomae, rheum officinale, radix bupleuri, Chinese barberry roots, semen sojae germinatum, Chinese yams, lonicerae flos, concretio silicea bambusae, rainbow conk, ligusticum and herba epimedii. The traditional Chinese medicine for preventing the influenza can inhibit virus replication, adjust the immune function and realize a broad-spectrum antibacterial effect, has a good effect on prevention of the influenza, is not prone to development of drug resistance and free from toxic and side effects and adverse reactions and can adjust the immune functions of human bodies well.

Description

Be used for preventing grippal Chinese medicine preparation

Technical field

The present invention relates to the medical domain of preventing epidemic, relate in particular to a kind of for preventing grippal Chinese medicine preparation.

Background technology

Influenza (abbreviation influenza) is the acute respiratory disease with hyperinfection being caused by influenza virus.Influenza is very huge to the harm of human health, be mainly manifested in its frequent occur popular, propagate rapidly, the aspect such as the general susceptible of crowd, number of the infected are numerous, with and can cause serious complication.Therefore the preventing and controlling of influenza are very important.

At present inoculation influenza vaccines are the effective measures of flu-prevention.Whole virus vaccine has good effectiveness and safety, and inoculation effective percentage can reach 60%～90%; The immunoreation occurring after subunit vaccine inoculation is weaker than whole virus vaccine; Inoculation live vaccine can obtain the cross immunity to various flows Influenza Virus.But because antigenic variation often occurs influenza virus surface glycoprotein (being mainly hemagglutinin HA and neuraminidase NA); and the research of vaccine often lags behind the generation of novel strain; this makes virus can successfully escape host's immunoprotection; and vaccine is very little to nothing, the old man of weak immunne response and the protective effect of infant, bring great difficulty to the prevention of influenza.

Modern medicine mainly comprises two aspects to the treatment of influenza, the one, and symptomatic treatment, as applied antipyretic analgesic, alleviate nasal mucosa congested medicine, eliminating phlegm and stopping cough medicine, preventing and treating secondary bacterial infection medicine etc.; The 2nd, antiviral therapy, in morbidity, 48h is better with interior trial effect, mainly comprises the medicine of following type: 1, neuraminidase inhibitor: represent that medicine is Oseltamivir (oseltamivir phosphate capsule) and zanamivir.But the report of existing many influenza virus to neuraminidase inhibitor drug resistance in recent years; Neuraminidase inhibitor also has the untoward reaction such as nausea,vomiting,diarrhea, stomachache, gastrointestinal upset, headache, dizziness, insomnia, tired, cough, nasal obstruction, pharyngalgia; To 12 years old following child, should be cautious use of neuraminidase inhibitor; This product and metabolite thereof can be by galactopoiesiss in addition, and gestation and nursing women need be cautious use of; Chronic obstructive pulmonary disease, asthma person likely occur that bronchospasm and pulmonary function reduce after applying zanamivir, therefore, old people, suffer from asthma, chronic respiratory tract disease person, unstability chronic disease person, immunologic inadequacy person, obstructive pulmonary patient and should be cautious use of; 2, ion channel M2 blocker: represent that medicine is amantadine and rimantadine.But this type of medicine only acts on viral M2 albumen.Because Influenza B virus does not have M2 albumen, therefore, amantadine and rimantadine are invalid to Type B influenza virus, and easily produce drug resistance, and have the side effect such as insomnia, anxiety, absent minded, regurgitation; 3, stop copying of viral nucleic acid: represent that medicine is that ribavirin is virazole.But having been reported ribavirin can cause allergy, anaphylactic shock, systemic bleeding and cause the untoward reaction such as disseminated inravascular coagulation, aplastic anemia sample anemia, cardiovascular system and gastrointestinal tract; 4, stop viral messenger RNA translation medicine: represent that medicine is interferon, but interferon can cause leukocyte, thrombocytopenia etc.

Motherland's medical science is early on the books aspect the preventing and treating of influenza, and has accumulated rich experience, and advantage is more obvious, is mainly manifested in: 1, resources of Chinese medicinal herb is in the Nature, and medicine source is extensive, and to human body, nontoxic or toxicity and untoward reaction are less, and cheap; 2, resisting pathogenic microbes spectrum is wide, and particularly a part of Chinese herbal medicine wherein not only has broad-spectrum disease resistance toxic action, and has broad-spectrum antibacterial action.This with only have the Western medicine of antivirus action and only have the antibiotic of antibacterial action far different; 3, aspect antiviral and antibacterial action, pathogenic microorganism to Chinese herbal medicine particularly compound recipe be difficult for to produce drug resistance.And between some Chinese herbal medicine, also demonstrated synergism; 4. most of Chinese herbal medicine with antiviral, antibacterial action, regulates the effect of body's immunity in addition.Therefore, Chinese medicine has unique advantage and vast potential for future development preventing and treating aspect influenza.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of for preventing grippal Chinese medicine preparation, it can suppress virus replication, regulate immunologic function, broad-spectrum antiseptic, the prevention of popularity flu has good effect, be difficult for producing drug resistance, have no side effect and untoward reaction, well mediator's body immunity function.

For solving the problems of the technologies described above, the invention provides a kind ofly for preventing grippal Chinese medicine, its crude drug comprises: Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

Wherein, in described Chinese medicine, the weight portion of each crude drug is respectively Folium Isatidis 75 weight portion～85 weight portions, Radix Sophorae Tonkinensis 35 weight portion～45 weight portions, Herba Moslae 20 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Platycodonis 20 weight portion～30 weight portions, Herba Abri 35 weight portion～45 weight portions, Herba Artemisiae Annuae 25 weight portion～35 weight portions, Folium Ginseng 45 weight portion～55 weight portions, the Radix Angelicae Dahuricae 30 weight portion～40 weight portions, the Rhizoma Anemarrhenae 40 weight portion～50 weight portions, Rhizoma Paridis 20 weight portion～30 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Flos Caryophylli 15 weight portion～25 weight portions, Herba Senecionis Scandentis 25 weight portion～35 weight portions, Rhizoma Imperatae 30 weight portion～40 weight portions, Rhizoma Dryopteris Crassirhizomatis 45 weight portion～55 weight portions, Radix Et Rhizoma Rhei 30 weight portion～40 weight portions, Radix Bupleuri 25 weight portion～35 weight portions, Radix Berberidis 30 weight portion～40 weight portions, Semen Glycine Germinatum 20 weight portion～30 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions, Flos Lonicerae 30 weight portion～40 weight portions, Concretio Silicea Bambusae 40 weight portion～50 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～30 weight portions, Rhizoma Ligustici 25 weight portion～35 weight portions and Herba Epimedii 35 weight portion～45 weight portions.

Wherein, in described Chinese medicine, the weight portion of each crude drug is most preferably respectively Folium Isatidis 80 weight portions, Radix Sophorae Tonkinensis 40 weight portions, Herba Moslae 25 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Platycodonis 25 weight portions, Herba Abri 40 weight portions, Herba Artemisiae Annuae 30 weight portions, Folium Ginseng 50 weight portions, the Radix Angelicae Dahuricae 35 weight portions, the Rhizoma Anemarrhenae 45 weight portions, Rhizoma Paridis 25 weight portions, Fructus Arctii 30 weight portions, Flos Caryophylli 20 weight portions, Herba Senecionis Scandentis 30 weight portions, Rhizoma Imperatae 35 weight portions, Rhizoma Dryopteris Crassirhizomatis 50 weight portions, Radix Et Rhizoma Rhei 35 weight portions, Radix Bupleuri 30 weight portions, Radix Berberidis 35 weight portions, Semen Glycine Germinatum 25 weight portions, Rhizoma Dioscoreae 40 weight portions, Flos Lonicerae 35 weight portions, Concretio Silicea Bambusae 45 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Rhizoma Ligustici 30 weight portions and Herba Epimedii 40 weight portions.

Wherein, the dosage form of described Chinese medicine is granule and tablet.

The present invention also provides the preparation method of above-mentioned Chinese medicine, and when the dosage form of described Chinese medicine is granule, concrete steps are:

The first step, is mixed in proportion Folium Isatidis, Radix seu Herba Gei aleppici, Herba Abri, Folium Ginseng, Fructus Arctii, Semen Glycine Germinatum, Rhizoma Dioscoreae and Herba Epimedii, adds the ethanol that 15～25 times of determining alcohols of mixture quality are 75%～85%, stir, sealing is soaked 4～6 days, obtains soak, and soak is by percolate pot percolation, flow is 3～5ml per minute, collect percolate, filter, filtrate is under-0.09～-0.06MPa, 50～70 ℃ of conditions, reclaim solvent, vacuum concentration becomes the extractum of relative density 1.15-1.20;

Second step, by macroporous resin adsorption on extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 2～3:1, and first water rushes to effluent colourlessly, uses subsequently the ethanol elution that the determining alcohol with respect to 5～7 times of the quality of macroporous adsorbent resin is 60%～80%, collect eluent, be evaporated to without alcohol taste, then add determining alcohol be 70%～80% ethanol to alcohol volume content to account for total liquor capacity be 55%～65% (V/V), standing precipitate with ethanol, filter, obtain the first filtrate;

The 3rd step, remaining component is mixed in proportion, the distilled water that adds 5～7 times of amounts of these component raw material medicine gross weight meters, decoct 2～4 hours, filter, the distilled water that adds 5～7 times of amounts of these component raw material medicine gross weight meters in medicinal residues, decoct 1～3 hour, filter, merging filtrate, at thickening temperature, it is 60 ℃, vacuum is under the condition of-0.02～-0.1Mpa, be concentrated into the clear paste that at 60 ℃, relative density is 1.1～1.3, let cool, it is that 70%～80% ethanol limit is stirred to ethanol volumn concentration to account for overall solution volume be 50%～60% (V/V) that limit adds determining alcohol, placement is spent the night, filter, the determining alcohol that filtering residue adds with respect to 2～4 times of its quality is 70%～80% ethanol, fully stir, filter, merge filtrate twice, the first filtrate obtaining with second step mixes, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, be ground into powder, obtain dried cream powder,

The 4th step, adds dextrin and sucrose subsequently, with respect to the dried cream powder of 100 weight portions; the addition of dextrin is 100 weight portion～150 weight portions, and the addition of sucrose is 250 weight portion～350 weight portions, is placed in wet granulator; mix 3～8 minutes; granulation, sends in vacuum drier and carries out vacuum drying, and temperature of charge is 40～70 ℃; vacuum is-0.08Mpa～-0.12Mpa; charging rate is 15～20L/h, and material strip transfer rate is 20～30cm/min, dry rear subpackage.

The present invention also provides the preparation method of above-mentioned Chinese medicine, and when the dosage form of described Chinese medicine is tablet, concrete steps are:

The 4th step, after the microcrystalline Cellulose of the sodium carboxymethyl cellulose of the polyvinylpyrrolidone of the dried cream powder of acquisition 100 weight portions and 60～100 weight portions, 30～50 weight portions, 120～180 weight portions is mixed, with the determining alcohol of 20～30 weight portions, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying in 45 ℃～50 ℃ temperature ranges, with 16 mesh sieve granulate, and add after the magnesium stearate of 7～9 weight portions and the micropowder silica gel of 6～8 weight portions, material is pressed into medicinal tablets.

It is a kind of for preventing grippal Chinese medicine granules that the present invention also provides, and its crude drug comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

It is a kind of for preventing grippal Chinese medicinal tablet that the present invention also provides, and its crude drug comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

The present invention also provides above-mentioned Chinese medicine in the application for the preparation of in the grippal medicament of prevention.

Beneficial effect of the present invention:

Provided by the invention for preventing grippal Chinese medicine, can suppress virus replication, regulate immunologic function, broad-spectrum antiseptic, the prevention of popularity flu has good effect, is difficult for producing drug resistance, have no side effect and untoward reaction, well mediator's body immunity function.

The specific embodiment

Influenza is equivalent to the traditional Chinese medical science it " influenza ", the ancient frigiogenous pestilence that claims, its describe " TAI YANG syndrome " " YANG MING syndrome " " Shaoyang disease " of sporadically appearing respectively in typhoid fever and " pathogenic wind-warm " in epidemic febrile disease, " spring-warm syndrome " " hygropyrexia " " disease due to latent summer-heat pathogen " " winter-warm syndrome " etc. various in.And the name head of " flu " sees all wind > of Yang Shiying < < Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House in a Northern Song Dynasty > piece of writing, this book proposes when discussing the shensu drink of < < prescription of peaceful benevolent dispensary > >: " ailment said due to cold or exposure cures cold; fever and headache; cough low voice speaking, tears saliva thickness." later age doctor gradually " " word is decided to be a name of disease to flu, uses till today.The name of influenza is proposed in < < Lei Zheng Zhi Cai cold opinion is controlled a > > piece of writing to the Lin Peiqin of the Qing Dynasty: " influenza; alternate attack of chill and fever, catches cold lossless, shensu drink; Renshen Baidu San, and refreshing art is loose.”

" time row " two word lexical or textual analysis have three: one, " time " refer to that morbidity has strict seasonality; " OK " refer to inappropriate the popular of epidemic disease poison that cause of weather.Primary disease is clinical common diseases caused by exogenous pathogenic factor infectious disease, due to epidemic disease due to heat pathogen, cold epidemic disease Virus entry human body.So-called God's will is missed the season should be warm and anti-cold while being the spring, and the winter should tremble with fear and anti-warm, and epidemic disease heresy is grown thickly, and is easy to primary disease popular.People is among gas is handed over, and pestilential pathogen enters with breathing, and people feels it, and the lighter is without significant discomfort, heavy feel and i.e. disease, and disease is weakened body resistance in interior, can not resist heresy to go out.

Epidemic disease person is divided into epidemic disease due to heat pathogen, cold epidemic disease, dry epidemic disease, epidemic caused by fire pathogen, wet epidemic disease and summer-heat epidemic disease, take epidemic disease due to heat pathogen, cold epidemic disease invasion and attack human body as main.The evil convict of six climate exopathogens must be pressed from both sides epidemic disease virus, and epidemic disease is many to be entered from respiratory tract, and its evil visitor of institute, starts from and defend gas.Defend gas and be the evil Shu Buneng of institute imperial evil in outside, then by air flue, invade and hinder in lung, by the network of lung, involved in stomach.Heavy by seeking and blood, battalion defends imbalance, can not refuse heresy, and You Xue overtaxes one's nerves in road bright.The no morbidity of pathogenic factor attack human physical ability, depends on the power of widow and poison more than the prosperity and decline, epidemic disease poison of healthy energy.

" institute of heresy gathers, and its gas must be empty ", if human body natural endowment is weak, healthy energy virtual loss, or daily life is careless, defends gas impaired, and space between skin and muscles is not solid, just exopathogen can be violated and defend in an opponent's defence.The mark of defensive QI belonging to vital QI, it is hot in nature.Heat is sun, by air flue, Ying Weizhi road spreading in table, warm boundary between muscles, fertile space between skin and muscles, defends outer function with row.Disease starts to be defended, in pathogen, invade, and the healthy energy person that slightly do not decline, that touches is sick.Defend gas and pathogen disaccords, Wei Yu is depressed, loathing of cold high fever, Blushing, mouth and nose gas heat, systemic pain.If pathogenic factor is contained, weakness of defensive QI person can not ask heresy to go out, and heresy must be violated in lung.Lung governing qi belongs to be defended, and lung wound respectful falling is had no right, and controls joint not normal, causes clearing heat in QI system to enter, and foul smell do not draw, lung is accumulate in the turbid interior life of expectorant.Withering lung lobes with stuffy lung-QI, channels is injured, raw in blood stasis, phlegm and blood stasis, obstruction of lung-QI, disease sees high heat, breathes with cough, uncomfortable in chest, bloody sputum etc.As evil Sheng of just declining, can defend and directly violate nutrient blood without lung.Nutrient QI belonging to blood is on foot, and blood is for seeking originally, by the heart is led.Therefore, the evil inevitable interior telepathy bag of nutrient blood of violating.Pericardium is gods department, thus pericardium be subject to heresy must and gods, cause brains key network unfavorable, visible headache as split, in a certain state of delirium, hyperpyrexia, quiet language is manic, the marquis of convulsions.More have middle coke gasification unfavorable, on pathogenic factor, be subject to, Zhi Quzhong road taste, lie prostrate in pleurodiaphragmatic in terspace person.Taste are impaired, transporting imbalance, and the intestines and stomach is disturbed by evil poison.Disturb in stomach, its gas superinverse, therefore nausea and vomiting; Disturb in intestinal, be subject to contain dereliction of duty, it is unfavorable to conduct, abdominal pain diarrhea.Defend gas stranded, space between skin and muscles is not opened, struggle between vital QI and pathogen, and the excessive air supporting of heat is got in table, therefore fever with chills.In a word, epidemic disease pathogenic factor is invaded human body approach three: one, and heresy is subject to from above, invades the criminal's of defending lung; The 2nd, directly violate nutrient blood, the pathogen attacking the pericardium adversely, gods are got involved, and brains are unfavorable, and machine key is obstructed; The 3rd, though evil, from above, be subject to, Dan Zhiquzhong road, lies prostrate in pleurodiaphragmatic in terspace, inside sees that taste are dull, sees that to defend gas stranded outward.Struggle between vital QI and pathogen is determining whether to fall ill and is running through Disease evolution process all the time.Once morbidity, good and evil both sides' growth and decline, strong and weak contrast is the key link that determines that primary disease prognosis lapses to.After the evil morbidity of sense, good and evil are handed over and are striven, and malicious evil phlegm-turbidity and blood stasis blood is continuous raw, also loss healthy energy.As gradually multiple in healthy energy, exopathogen gradually goes, and the malicious expectorant stasis of blood is able to gradually clear, forms the micro-gesture of positive exogenous pathogen, and pathogenesis is prognosis bona to healing; As vital QI cannot conquer pathogen, the expectorant poison stasis of blood is tied mutually, block of lung-QI, and vigour consume, forms the evil gesture that falls into unconsciousness and collapse, prognosis mala.Because influenza is influenza because being invaded by exogenous pathogen causes and has heating paresthesia, therefore always belong to fever caused by exogenous pathogenic factors.

Based on above-mentioned theory of Chinese medical science, the present invention is with dispelling wind pathogens, clearing away summer-heat and eliminating dampness, supplementing QI for expelling the pathogenic factors from the body surface, enhancing body resistance are principle, provide a kind of for preventing grippal Chinese medicine, its crude drug comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

In side, Folium Isatidis is applicable to heat and enters the cards such as nutrient blood, intense heat in both QI and blood systems, maculae caused by violent heat pathogen and pharyngeal swelling aphtha.Pharmacological evaluation shows, Folium Isatidis has antibacterial, antiviral, antipyretic, antiinflammatory, function of gallbladder promoting, the effect such as antiendotoxin and enhancing immunity, matrine alkaloid in Radix Sophorae Tonkinensis can lure that leukocyte produces interferon into, thereby realize viral infection resisting, the volatile oil of Herba Moslae has broad-spectrum antiseptic and bactericidal action and directly suppresses the effects such as influenza virus, Radix seu Herba Gei aleppici can promote the secretion performance immunoregulation effect of part cytokine, strengthen the phagocytic function of reticuloendothelial system, make blood leukocytes number, macrophage phagocytic index significantly raises, thereby suppress influenza virus, Radix Platycodonis is opened lung qi dispersing gas, lung qi dispersing cough-relieving, the damp eliminating of Herba Abri heat-clearing and toxic substances removing, Herba Artemisiae Annuae clearing away summer-heat, except steaming, the effect of preventing the attack (or recurrence) of malaria, modern study shows, Herba Artemisiae Annuae has infection, antiviral, antipyretic, antiinflammatory, analgesia and raising immunity, Folium Ginseng is QI invigorating group medicine, QI invigorating is with the poison of holder diseases caused by exogenous pathogenic factor, treating the location first where the pathogens havn’t intruded yet, make body healthy energy sufficient, thereby it is strong to get rid of evils, the Radix Angelicae Dahuricae and the Rhizoma Anemarrhenae share, be pungent loose medicine, an and Wen Yihan, be made as mutually use, deposit its with and make it is inclined to one side, the Radix Angelicae Dahuricae obtains the Rhizoma Anemarrhenae, do not have the fraud of antiperspirant, the Rhizoma Anemarrhenae obtains the Radix Angelicae Dahuricae, led off interior hot and suffocating, two medicines one induce sweat, one clear in, the common core medicine pair that forms relieving exterior-interior syndrome, Rhizoma Paridis heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc., arctigenin can directly suppress or inactivating influenza virus, make it produce stronger In Vitro Anti influenza A virus effect, Flos Caryophylli has the effect of broad-spectrum antiseptic, Rhizoma Imperatae has diuresis, hemostasis, the effects such as antibacterial and immunomodulating, Rhizoma Dryopteris Crassirhizomatis has the effect of anti-influenza A virus FM1 strain, Radix Bupleuri reconciling superficies and interior, the resolving depression of bringing down a fever, Radix Berberidis heat clearing and damp drying, eliminating fire and detoxication, Semen Glycine Germinatum expelling superficial pathogens and clearing away summer-heat, clearing away heat-damp and promoting diuresis, Radix Et Rhizoma Rhei removing pathogenic heat from blood and toxic substance from the body, dampness removing jaundice eliminating, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, the kidney invigorating arresting seminal emission, Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens, Herba Senecionis Scandentis heat-clearing and toxic substances removing, improving eyesight dampness removing, Concretio Silicea Bambusae clear heat and eliminate phlegm, cool heart arresting convulsion, Coriolous Dersicolor (Fr.) Quel invigorating spleen to remove dampness, heat-clearing and toxic substances removing, Rhizoma Ligustici expelling wind and cold, removing damp and stopping pain, Herba Epimedii kidney-replenishing, bone and muscle strengthening, all medicines share, play altogether dispelling wind pathogens, clearing away summer-heat and eliminating dampness, supplementing QI for expelling the pathogenic factors from the body surface, the merit of enhancing body resistance.

Folium Isatidis: latin name Isatidis Folium, bitter in the mouth, property Great Cold, GUIXIN, liver, gallbladder, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, the effect of jaundice eliminating, the excess-heat can clearing heat in QI system dividing, can separate the pyretic toxicity of blood system again, the high febrile perspiration being mainly used in due to pestilence calentura goes out, excessive thirst taking fluids profusely; The speckle of sending out that fire-toxin is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash color is purple dark; Dampness-heat in the liver and gallbladder is accumulate the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The cards such as the pharyngalgia due to fire stagnation pyretic toxicity, aphtha of the mouth and tongue, hepatitis.

Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, enter the heart, lung, large intestine channel, there is resolving toxin and disinhibiting the throat, clearing away heat-damp and promoting diuresis, the effect that parasite killing is anticancer, for laryngopharynx swelling and pain, swelling of the gum toothache, cough due to lung-heat, dysentery, jaundice, the cards such as the swollen tinea alba of heat.

Herba Moslae: acrid in the mouth, sweet, warm in nature, return lung, stomach, spleen channel, energy diaphoresis expelling summer-heat, row water wet dissipation, stomach warming cures mainly diaphoresis expelling summer-heat in adjusting, and row water wet dissipation, during stomach warming is adjusted.Control Xia Yue sense cold fluid-retention cold, have a headache and fever, aversion to cold is lossless, feeling of stuffiness in chest stomachache, vomiting and diarrhoea, edema, the cards such as beriberi.

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is flat, returns liver, spleen, lung meridian, has analgesia, blood pressure lowering, regulating menstruation, the effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison, the cards such as traumatic injury are controlled in external.

Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enters lung meridian, has the effect of expelling phlegm for arresting cough, lung qi dispersing evacuation of pus, cures mainly the cards such as cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Herba Abri: sweet in the mouth, hardship, cool in nature, GUIXIN; Lung; Liver; Stomach; Kidney channel, has clearing away heat-damp and promoting diuresis, the effect of eliminating stasis to stop pain, main treatment icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, the cards such as mastalgia.

Herba Artemisiae Annuae: latin name Artemisiae Annuae Herba, bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, have deficiency-heat clearly thoroughly, removing heat from blood is except steaming, and except steaming, the effect of preventing the attack (or recurrence) of malaria, cures mainly pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, the cards such as jaundice due to damp-heat.

Folium Ginseng: bitter in the mouth, sweet, cold in nature, attach to the lung and stomach meridians, there is QI invigorating, lung benefiting, drives away summer heat, and the effect of promoting the production of body fluid, cures mainly qi-asthenia cough, and summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, the tired weary card that waits of extremity.

The Radix Angelicae Dahuricae: latin name Angelicae Dahuricae Radix, acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling of inducing sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, the effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

The Rhizoma Anemarrhenae: latin name Anemarrhenae Rhizoma, bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Rhizoma Paridis: bitter in the mouth, pungent, cold in nature, GUIXIN, Liver Channel, have heat-clearing and toxic substances removing, antiasthmatic-antitussive, the effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., cures mainly carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, the cards such as snake bite and insect sting.

Fructus Arctii: acrid in the mouth, hardship, cold in nature, enter lung, stomach warp, have wind-dispelling heat-dissipating, lung qi dispersing rash, subduing swelling and detoxicating, the effect of sore-throat relieving, be mainly used in anemopyretic cold and epidemic febrile disease from the beginning of; The headache of attacking in wind-fire or expectorant heat, the pharyngalgia of wind-heat invading the lung, impairment of dispersing and descending function of the lung, sore throat, cough with asthma, edema; The arthralgia of damp-heat arthralgia resistance; Measles without adequate eruption due to the strongly fragrant pen of wind heat, macule pathogenic heat is stopped up stagnant all cards; The cards such as furuncle swelling toxin of burning hot poison knot.

Flos Caryophylli: sweet in the mouth, pungent, extremely hot in nature, there is warming the stomach, the effect of the kidney warming, for cards such as cold syndrome of the stomach pain with distension, singultus, vomiting and diarrhoea, arthralgia pain, colic, halitosis, toothache.

Herba Senecionis Scandentis: cold in nature, bitter in the mouth, returns lung, Liver Channel, has heat-clearing and toxic substances removing, the effect that improving eyesight is antipruritic.For cards such as anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema, furuncle.

Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, small intestine meridian, there is cooling blood for hemostasis, clearing away heat and promoting diuresis effect, cures mainly heat in blood and spits blood, epistaxis spitting of blood, hematuria, metrorrhagia, purpura, calentura excessive thirst, gastric heat vomiting, dyspnea and cough due to lung-heat, the puckery pain of dribbling urination, edema, the cards such as jaundice.

Rhizoma Dryopteris Crassirhizomatis: cold nature, bitter in the mouth, returns liver, stomach warp, has heat-clearing and toxic substances removing, anthelmintic, the effect of hemostasis, cures mainly cards such as preventing influenza, abdominal pain due to worm stagnation, metrorrhagia.

Radix Et Rhizoma Rhei: latin name Rhei Radix et Rhizoma, bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.

Radix Bupleuri: bitter in the mouth, cold nature, returns liver, gallbladder meridian, has to evacuate to bring down a fever, and the effect of yang invigorating soothing liver-QI, cures mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.

Radix Berberidis: bitter in the mouth, cold in nature, to return and there is heat clearing and damp drying, the effect of eliminating fire and detoxication, cures mainly damp-heat dysentery, jaundice, eczema, pharyngalgia conjunctival congestion, the cards such as carbuncle sore tumefacting virus.

Semen Glycine Germinatum: latin name Sojae semen germinatum, sweet in the mouth, property is flat, returns spleen, stomach, lung meridian, has expelling superficial pathogens and clearing away summer-heat, the effect of clearing away heat-damp and promoting diuresis, cures mainly summer-heat damp cold, hygropyrexia from the beginning of, heating antiperspirant is few, gastral cavity painful abdominal mass uncomfortable in chest, vague aching of limbs, the cards such as dysuria.

Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Flos Lonicerae: sweet in the mouth, cold in nature, return lung, the heart, stomach warp, there is the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cure mainly carbuncle furuncle, sore throat, red heat, toxic-heat and blood stasis, anemopyretic cold, the cards such as epidemic febrile disease.

Concretio Silicea Bambusae: sweet in the mouth, cold in nature, there is clear heat and eliminate phlegm, the effect of cool heart arresting convulsion, cures mainly calentura coma delirium, and middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.The cards such as phlegm-heat cough.

Coriolous Dersicolor (Fr.) Quel: latin name Coriolus, sweet in the mouth, light, cold nature, returns liver; Spleen; Lung meridian, has invigorating spleen to remove dampness; Relieving cough and asthma; Heat-clearing and toxic substances removing; Antineoplastic effect, cures mainly chronic active hepatitis; Hepatitis interstitialis chronica; Chronic bronchitis; Infantile spasm bronchitis; Laryngopharynx swelling and pain; Kinds of tumors; Rheumatoid arthritis; The cards such as leukemia.

Rhizoma Ligustici: latin name Rhizoma Ligustici, acrid in the mouth, warm in nature, return urinary bladder channel, have and dispel the wind, cold expelling, dehumidifying, the effect of pain relieving, cures mainly headche due to wind-cold, wind syndrome of head hemialgia, blurred vision nasal obstruction, toothache gingival atrophy, rheumatic arthralgia, cold-damp stomachache is had loose bowels, pruritus due to wind pathogen scabies, the effect of married woman's YIN-cold hernia abdominal mass.

Herba Epimedii: acrid in the mouth, sweet, warm in nature, enter liver, kidney channel, there is kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling,, cold extremities with aversion to cold soft for impotence due to deficiency of the kidney, seminal emission premature ejaculation, waist knee joint flaccidity; The cards such as arthralgia due to cold-dampnes or spasm of the limbs are numb, Herba Epimedii can strengthen gonad function, promotes estrogen secretion and follicular development and promotes that Fallopian tube mucosa thickens, and extends egg-laying peak, can also promote that in yang deficiency animal body, DNA is synthetic, make its synthetic ratio approach normal level simultaneously.

Preferably, described Chinese medicine only consists of above-mentioned raw materials medicine.

In described Chinese medicine, the weight portion of each crude drug is respectively Folium Isatidis 75 weight portion～85 weight portions, Radix Sophorae Tonkinensis 35 weight portion～45 weight portions, Herba Moslae 20 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Platycodonis 20 weight portion～30 weight portions, Herba Abri 35 weight portion～45 weight portions, Herba Artemisiae Annuae 25 weight portion～35 weight portions, Folium Ginseng 45 weight portion～55 weight portions, the Radix Angelicae Dahuricae 30 weight portion～40 weight portions, the Rhizoma Anemarrhenae 40 weight portion～50 weight portions, Rhizoma Paridis 20 weight portion～30 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Flos Caryophylli 15 weight portion～25 weight portions, Herba Senecionis Scandentis 25 weight portion～35 weight portions, Rhizoma Imperatae 30 weight portion～40 weight portions, Rhizoma Dryopteris Crassirhizomatis 45 weight portion～55 weight portions, Radix Et Rhizoma Rhei 30 weight portion～40 weight portions, Radix Bupleuri 25 weight portion～35 weight portions, Radix Berberidis 30 weight portion～40 weight portions, Semen Glycine Germinatum 20 weight portion～30 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions, Flos Lonicerae 30 weight portion～40 weight portions, Concretio Silicea Bambusae 40 weight portion～50 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～30 weight portions, Rhizoma Ligustici 25 weight portion～35 weight portions and Herba Epimedii 35 weight portion～45 weight portions.

In described Chinese medicine, the weight portion of each crude drug is preferably respectively Folium Isatidis 80 weight portion～85 weight portions, Radix Sophorae Tonkinensis 40 weight portion～45 weight portions, Herba Moslae 25 weight portion～30 weight portions, Radix seu Herba Gei aleppici 55 weight portion～60 weight portions, Radix Platycodonis 25 weight portion～30 weight portions, Herba Abri 40 weight portion～45 weight portions, Herba Artemisiae Annuae 30 weight portion～35 weight portions, Folium Ginseng 50 weight portion～55 weight portions, the Radix Angelicae Dahuricae 35 weight portion～40 weight portions, the Rhizoma Anemarrhenae 45 weight portion～50 weight portions, Rhizoma Paridis 20 weight portion～25 weight portions, Fructus Arctii 25 weight portion～30 weight portions, Flos Caryophylli 15 weight portion～20 weight portions, Herba Senecionis Scandentis 25 weight portion～30 weight portions, Rhizoma Imperatae 30 weight portion～35 weight portions, Rhizoma Dryopteris Crassirhizomatis 45 weight portion～50 weight portions, Radix Et Rhizoma Rhei 30 weight portion～35 weight portions, Radix Bupleuri 25 weight portion～30 weight portions, Radix Berberidis 30 weight portion～35 weight portions, Semen Glycine Germinatum 20 weight portion～25 weight portions, Rhizoma Dioscoreae 35 weight portion～40 weight portions, Flos Lonicerae 30 weight portion～35 weight portions, Concretio Silicea Bambusae 40 weight portion～45 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～25 weight portions, Rhizoma Ligustici 25 weight portion～30 weight portions and Herba Epimedii 35 weight portion～40 weight portions.

In described Chinese medicine, the weight portion of each crude drug is preferably respectively Folium Isatidis 75 weight portion～80 weight portions, Radix Sophorae Tonkinensis 35 weight portion～40 weight portions, Herba Moslae 20 weight portion～25 weight portions, Radix seu Herba Gei aleppici 50 weight portion～55 weight portions, Radix Platycodonis 20 weight portion～25 weight portions, Herba Abri 35 weight portion～40 weight portions, Herba Artemisiae Annuae 25 weight portion～30 weight portions, Folium Ginseng 45 weight portion～50 weight portions, the Radix Angelicae Dahuricae 30 weight portion～35 weight portions, the Rhizoma Anemarrhenae 40 weight portion～45 weight portions, Rhizoma Paridis 25 weight portion～30 weight portions, Fructus Arctii 30 weight portion～35 weight portions, Flos Caryophylli 20 weight portion～25 weight portions, Herba Senecionis Scandentis 30 weight portion～35 weight portions, Rhizoma Imperatae 35 weight portion～40 weight portions, Rhizoma Dryopteris Crassirhizomatis 50 weight portion～55 weight portions, Radix Et Rhizoma Rhei 35 weight portion～40 weight portions, Radix Bupleuri 30 weight portion～35 weight portions, Radix Berberidis 35 weight portion～40 weight portions, Semen Glycine Germinatum 25 weight portion～30 weight portions, Rhizoma Dioscoreae 40 weight portion～45 weight portions, Flos Lonicerae 35 weight portion～40 weight portions, Concretio Silicea Bambusae 45 weight portion～50 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portion～30 weight portions, Rhizoma Ligustici 30 weight portion～35 weight portions and Herba Epimedii 40 weight portion～45 weight portions.

In described Chinese medicine, the weight portion of each crude drug is most preferably respectively Folium Isatidis 80 weight portions, Radix Sophorae Tonkinensis 40 weight portions, Herba Moslae 25 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Platycodonis 25 weight portions, Herba Abri 40 weight portions, Herba Artemisiae Annuae 30 weight portions, Folium Ginseng 50 weight portions, the Radix Angelicae Dahuricae 35 weight portions, the Rhizoma Anemarrhenae 45 weight portions, Rhizoma Paridis 25 weight portions, Fructus Arctii 30 weight portions, Flos Caryophylli 20 weight portions, Herba Senecionis Scandentis 30 weight portions, Rhizoma Imperatae 35 weight portions, Rhizoma Dryopteris Crassirhizomatis 50 weight portions, Radix Et Rhizoma Rhei 35 weight portions, Radix Bupleuri 30 weight portions, Radix Berberidis 35 weight portions, Semen Glycine Germinatum 25 weight portions, Rhizoma Dioscoreae 40 weight portions, Flos Lonicerae 35 weight portions, Concretio Silicea Bambusae 45 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Rhizoma Ligustici 30 weight portions and Herba Epimedii 40 weight portions.

The dosage form of Chinese medicine provided by the invention can be any regular dosage form, is preferably granule and tablet.

Chinese medicine granules of the present invention and tablet can adopt conventional preparation method preparation.

Preferably, the present invention also provides the preparation method of above-mentioned Chinese medicine, and when the dosage form of described Chinese medicine is granule, concrete steps are:

The 4th step adds dextrin and sucrose in dried cream powder, with respect to the dried cream powder of 100 weight portions; the addition of dextrin is 100 weight portion～150 weight portions, and the addition of sucrose is 250 weight portion～350 weight portions, is placed in wet granulator; mix 3～8 minutes; granulation, sends in vacuum drier and carries out vacuum drying, and temperature of charge is 40～70 ℃; vacuum is-0.08Mpa～-0.12Mpa; charging rate is 15～20L/h, and material strip transfer rate is 20～30cm/min, dry rear subpackage.

Preferably, the present invention also provides the preparation method of above-mentioned Chinese medicine, and when the dosage form of described Chinese medicine is tablet, concrete steps are:

Preparation method of the present invention is not limited to said method, and the conventional method of preparing granule and mixture all can be applicable to the present invention.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 granule 1

By Folium Isatidis 80g, Radix seu Herba Gei aleppici 55g, Herba Abri 40g, Folium Ginseng 50g, Fructus Arctii 30g, Semen Glycine Germinatum 25g, Rhizoma Dioscoreae 40g and Herba Epimedii 40g mix, and adding 7.2kg determining alcohol is 80% ethanol, stirs, and sealing is soaked 6 days, obtains soak, and soak is by percolate pot percolation, and flow is 3ml per minute, collects percolate, filter, and filtrate is at-0.07MPa, under 60 ℃ of conditions, reclaim solvent, vacuum concentration becomes the extractum of relative density 1.15, by D101 macroporous resin adsorption on extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 3:1, first water rushes to effluent colourless, use subsequently the ethanol elution that the determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80%, collect eluent, be evaporated to without alcohol taste, then to add determining alcohol be that to account for total liquor capacity be 65% (V/V) for 80% ethanol to alcohol volume content, standing precipitate with ethanol, filter, obtain the first filtrate, by Radix Sophorae Tonkinensis 40g, Herba Moslae 25g, Radix Platycodonis 25g, Herba Artemisiae Annuae 30g, Radix Angelicae Dahuricae 35g, Rhizoma Anemarrhenae 45g, Rhizoma Paridis 25g, Flos Caryophylli 20g, Herba Senecionis Scandentis 30g, Rhizoma Imperatae 35g, Rhizoma Dryopteris Crassirhizomatis 50g, Radix Et Rhizoma Rhei 35g, Radix Bupleuri 30g, Radix Berberidis 35g, Flos Lonicerae 35g, Concretio Silicea Bambusae 45g, Coriolous Dersicolor (Fr.) Quel 25g, Rhizoma Ligustici 30g mixes, the distilled water that adds 3.6kg, decoct 4 hours, filter, the distilled water that adds 3.6kg in medicinal residues, decoct 3 hours, filter, merging filtrate, at thickening temperature, it is 60 ℃, vacuum is-condition of 0.08Mpa under, be concentrated into the clear paste that at 60 ℃, relative density is 1.3, let cool, it is that 80% ethanol limit is stirred to ethanol volumn concentration to account for overall solution volume be 60% (V/V) that limit adds determining alcohol, placement is spent the night, filter, the determining alcohol that filtering residue adds with respect to 3 times of its quality is 80% ethanol, fully stir, filter, merge filtrate twice, mix with the first filtrate obtaining above, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, be ground into powder, obtain dried cream powder, select 300g dried cream powder, add subsequently 300g dextrin and 750g sucrose, be placed in wet granulator, mix 8 minutes, granulation, send into and in vacuum drier, carry out vacuum drying, temperature of charge is 50 ℃, vacuum is-0.1Mpa, charging rate is 20L/h, material strip transfer rate is 30cm/min, subpackage after dry, every bag of 5g.

Embodiment 2 granules 2

By Folium Isatidis 75g, Radix seu Herba Gei aleppici 50g, Herba Abri 35g, Folium Ginseng 45g, Fructus Arctii 35g, Semen Glycine Germinatum 30g, Rhizoma Dioscoreae 45g and Herba Epimedii 45g mix, and adding 7.2kg determining alcohol is 80% ethanol, stirs, and sealing is soaked 6 days, obtains soak, and soak is by percolate pot percolation, and flow is 3ml per minute, collects percolate, filter, and filtrate is at-0.07MPa, under 60 ℃ of conditions, reclaim solvent, vacuum concentration becomes the extractum of relative density 1.15, by D101 macroporous resin adsorption on extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 3:1, first water rushes to effluent colourless, use subsequently the ethanol elution that the determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80%, collect eluent, be evaporated to without alcohol taste, then to add determining alcohol be that to account for total liquor capacity be 65% (V/V) for 80% ethanol to alcohol volume content, standing precipitate with ethanol, filter, obtain the first filtrate, by Radix Sophorae Tonkinensis 35g, Herba Moslae 20g, Radix Platycodonis 20g, Herba Artemisiae Annuae 25g, Radix Angelicae Dahuricae 30g, Rhizoma Anemarrhenae 40g, Rhizoma Paridis 30g, Flos Caryophylli 25g, Herba Senecionis Scandentis 35g, Rhizoma Imperatae 40g, Rhizoma Dryopteris Crassirhizomatis 55g, Radix Et Rhizoma Rhei 40g, Radix Bupleuri 35g, Radix Berberidis 40g, Flos Lonicerae 40g, Concretio Silicea Bambusae 50g, Coriolous Dersicolor (Fr.) Quel 30g, Rhizoma Ligustici 35g mixes, the distilled water that adds 4kg, decoct 4 hours, filter, the distilled water that adds 4kg in medicinal residues, decoct 3 hours, filter, merging filtrate, at thickening temperature, it is 60 ℃, vacuum is-condition of 0.08Mpa under, be concentrated into the clear paste that at 60 ℃, relative density is 1.3, let cool, it is that 80% ethanol limit is stirred to ethanol volumn concentration to account for overall solution volume be 60% (V/V) that limit adds determining alcohol, placement is spent the night, filter, the determining alcohol that filtering residue adds with respect to 3 times of its quality is 80% ethanol, fully stir, filter, merge filtrate twice, mix with the first filtrate obtaining above, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, be ground into powder, obtain dried cream powder, select 300g dried cream powder, add subsequently 300g dextrin and 750g sucrose, be placed in wet granulator, mix 8 minutes, granulation, send into and in vacuum drier, carry out vacuum drying, temperature of charge is 50 ℃, vacuum is-0.1Mpa, charging rate is 20L/h, material strip transfer rate is 30cm/min, subpackage after dry, every bag of 5g.

Embodiment 3 tablets 1

By Folium Isatidis 80g, Radix seu Herba Gei aleppici 55g, Herba Abri 40g, Folium Ginseng 50g, Fructus Arctii 30g, Semen Glycine Germinatum 25g, Rhizoma Dioscoreae 40g and Herba Epimedii 40g mix, and adding 7.2kg determining alcohol is 80% ethanol, stirs, and sealing is soaked 6 days, obtains soak, and soak is by percolate pot percolation, and flow is 3ml per minute, collects percolate, filter, and filtrate is at-0.07MPa, under 60 ℃ of conditions, reclaim solvent, vacuum concentration becomes the extractum of relative density 1.15, by D101 macroporous resin adsorption on extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 3:1, first water rushes to effluent colourless, use subsequently the ethanol elution that the determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80%, collect eluent, be evaporated to without alcohol taste, then to add determining alcohol be that to account for total liquor capacity be 65% (V/V) for 80% ethanol to alcohol volume content, standing precipitate with ethanol, filter, obtain the first filtrate, by Radix Sophorae Tonkinensis 40g, Herba Moslae 25g, Radix Platycodonis 25g, Herba Artemisiae Annuae 30g, Radix Angelicae Dahuricae 35g, Rhizoma Anemarrhenae 45g, Rhizoma Paridis 25g, Flos Caryophylli 20g, Herba Senecionis Scandentis 30g, Rhizoma Imperatae 35g, Rhizoma Dryopteris Crassirhizomatis 50g, Radix Et Rhizoma Rhei 35g, Radix Bupleuri 30g, Radix Berberidis 35g, Flos Lonicerae 35g, Concretio Silicea Bambusae 45g, Coriolous Dersicolor (Fr.) Quel 25g, Rhizoma Ligustici 30g mixes, the distilled water that adds 3.6kg, decoct 4 hours, filter, the distilled water that adds 3.6kg in medicinal residues, decoct 3 hours, filter, merging filtrate, at thickening temperature, it is 60 ℃, vacuum is-condition of 0.08Mpa under, be concentrated into the clear paste that at 60 ℃, relative density is 1.3, let cool, it is that 80% ethanol limit is stirred to ethanol volumn concentration to account for overall solution volume be 60% (V/V) that limit adds determining alcohol, placement is spent the night, filter, the determining alcohol that filtering residue adds with respect to 3 times of its quality is 80% ethanol, fully stir, filter, merge filtrate twice, mix with the first filtrate obtaining above, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, be ground into powder, obtain dried cream powder, select the polyvinylpyrrolidone of 500g dried cream powder and 400g, the sodium carboxymethyl cellulose of 200g, after the microcrystalline Cellulose of 750g mixes, with the determining alcohol of 150g, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying at 50 ℃ of temperature, with 16 mesh sieve granulate, and add after the magnesium stearate of 40g and the micropowder silica gel of 35g, material is pressed into medicinal tablets 1.

Embodiment 4 tablets 2

By Folium Isatidis 85g, Radix seu Herba Gei aleppici 60g, Herba Abri 45g, Folium Ginseng 55g, Fructus Arctii 25g, Semen Glycine Germinatum 20g, Rhizoma Dioscoreae 35g and Herba Epimedii 35g mix, and adding 7.2kg determining alcohol is 80% ethanol, stirs, and sealing is soaked 6 days, obtains soak, and soak is by percolate pot percolation, and flow is 3ml per minute, collects percolate, filter, and filtrate is at-0.07MPa, under 60 ℃ of conditions, reclaim solvent, vacuum concentration becomes the extractum of relative density 1.15, by D101 macroporous resin adsorption on extractum, the quality of extractum and the mass ratio of macroporous adsorbent resin are 3:1, first water rushes to effluent colourless, use subsequently the ethanol elution that the determining alcohol with respect to 6 times of the quality of macroporous adsorbent resin is 80%, collect eluent, be evaporated to without alcohol taste, then to add determining alcohol be that to account for total liquor capacity be 65% (V/V) for 80% ethanol to alcohol volume content, standing precipitate with ethanol, filter, obtain the first filtrate, by Radix Sophorae Tonkinensis 45g, Herba Moslae 30g, Radix Platycodonis 30g, Herba Artemisiae Annuae 35g, Radix Angelicae Dahuricae 40g, Rhizoma Anemarrhenae 50g, Rhizoma Paridis 20g, Flos Caryophylli 15g, Herba Senecionis Scandentis 25g, Rhizoma Imperatae 30g, Rhizoma Dryopteris Crassirhizomatis 45g, Radix Et Rhizoma Rhei 30g, Radix Bupleuri 25g, Radix Berberidis 30g, Flos Lonicerae 30g, Concretio Silicea Bambusae 40g, Coriolous Dersicolor (Fr.) Quel 20g, Rhizoma Ligustici 25g mixes, the distilled water that adds 3.6kg, decoct 4 hours, filter, the distilled water that adds 3.6kg in medicinal residues, decoct 3 hours, filter, merging filtrate, at thickening temperature, it is 60 ℃, vacuum is-condition of 0.08Mpa under, be concentrated into the clear paste that at 60 ℃, relative density is 1.3, let cool, it is that 80% ethanol limit is stirred to ethanol volumn concentration to account for overall solution volume be 60% (V/V) that limit adds determining alcohol, placement is spent the night, filter, the determining alcohol that filtering residue adds with respect to 3 times of its quality is 80% ethanol, fully stir, filter, merge filtrate twice, mix with the first filtrate obtaining above, concentrating under reduced pressure is except desolventizing, obtain and get dry extract, be ground into powder, obtain dried cream powder, select the polyvinylpyrrolidone of 500g dried cream powder and 400g, the sodium carboxymethyl cellulose of 200g, after the microcrystalline Cellulose of 750g mixes, with the determining alcohol of 150g, be that 95% ethanol is made soft material, 14 mesh sieves are granulated, vacuum drying at 50 ℃ of temperature, with 16 mesh sieve granulate, and add after the magnesium stearate of 40g and the micropowder silica gel of 35g, material is pressed into medicinal tablets 1.

Embodiment 5 acute toxicity testings

5.1 acute toxicity preliminary experiments

5.1.1 laboratory animal: 40 of healthy kunming mices, 15～20g, male and female half and half, are provided by Qingdao City's Experimental Animal Center.Sub-cage rearing, raising temperature is 25～35 ℃, humidity is 60%, raises with solid feed, freely drinks water.

5.1.2 test the granule 1 of medication: embodiment 1 preparation, be configured to the suspension of respective concentration, standby.

5.1.3 test method

Grouping: by 40 healthy mices, be divided at random 8 groups, 5 every group.7 administration groups wherein, 1 as blank group.

Dosage: establish 0.8g/kg, 1.1g/kg, 1.5g/kg, 2.1g/kg, 2.9g/kg, 4.1g/kg, 7 dosage groups of 5.7g/kg body weight according to the geometric progression of 1: 1.4.

Route of administration: fasting 8h(can't help water) after, each administration group is all calculated dosage by the weighing machine of every mice, and every mice all gavages and is administered once with metal stomach tube per os.Mice free choice feeding and the drinking-water of blank group.

Clinical observation: each organizes after mice administration Continuous Observation one week, observes at any time mice spirit, appetite, drinking-water, activity and has or not poisoning situation and record in time clinical manifestation and the animal dead number of mice, for formal test provides foundation.

Observation index:

Nervous system aspect: (1) behavior and reaction (comprise whether occurring undesired cry, agitation, uneasiness, irritability, hyperesthesia, few moving, drowsiness or stupor etc.); (2) motion (comprise whether occurring muscle twitches, stiff, forced movement, lax, paralysis etc.); (3) pupil and secretions (pupil have or not dwindle or expand, shed tears etc.).

Breathe and cardiovascular: have or not rapid breathing or slow, nose supersecretion, tactile pareordia heart rate speed etc. with excessivelying.

Gastrointestinal aspect: whether occur abdominal part flatulence or contraction and observe stool character and color and luster etc.

Genitourinary system: have or not and occur that labia, mammary gland swelling and perineal position are dirty.

Skin and hair: color, integrity, have or not hyperemia, cyanosis, pale, dermexanthesis, fur loose etc.

Other: claim appetite and body weight every day.

5.1.4 result

Administration group mice all the searching for food of survival and white mice, drinking-water, the mental status, active situation and defecation etc. does not all occur obviously abnormal, identical with the searching for food of blank mice, drinking-water, the mental status, active situation and defecation etc., the clinical manifestation of 7 dosage group white mice that this test arranges the Non Apparent Abnormality of comparing with the clinical manifestation of the white mice of blank group, illustrate Chinese medicine granules of the present invention on the clinical manifestation of white mice without impact.

This test does not have mice dying situation to occur, illustrates that this time to test set dosage less than normal.Therefore, when formal test, should strengthen dosage, to testing out the median lethal dose(LD 50) of Chinese medicine granules of the present invention, determine the size of its acute toxicity.

5.2 acute toxicity testing

On the basis of trial test, this test be take mice as experimental animal, take 5.0g/kg body weight as basal dose, according to the geometric progression of 1:1.2,6 dosage groups is set and carries out acute toxicity test.To calculating median lethal dose(LD 50), determine the acute toxicity size of Chinese medicine granules of the present invention.

5.2.1 laboratory animal: 70 of healthy kunming mices, 15～20g, male and female half and half, are provided by Qingdao City's Experimental Animal Center.Sub-cage rearing, raising temperature is 25～35 ℃, humidity is 60%, raises with solid feed, freely drinks water.

5.2.2 test the granule 1 of medication: embodiment 1 preparation, be configured to the suspension of respective concentration, standby.

5.2.3 test method

Grouping: by 70 healthy mices, be divided at random 7 groups, 10 every group.6 administration groups wherein, 1 as blank group.

Dosage and approach: on trial test basis, according to the geometric progression of 1: 1.2, establish 5.0g/kg, 6.0g/kg, 7.2g/kg, 8.6g/kg, 10.3g/kg, 6 dosage groups of 14.4g/kg body weight.After fasting 8h (can't help water), each administration group is all calculated dosage according to the weighing machine of every mice, and every mice all gavages and is administered once with metal stomach tube per os.Blank group mice free choice feeding and drinking-water.

Clinical observation: each organizes after mice administration Continuous Observation one week, observes at any time mice spirit, appetite, drinking-water, activity and has or not poisoning situation and record in time clinical manifestation and the animal dead number of mice.

Gross anatomy: dead white mice is cutd open to inspection in time, observe the variation of each internal organs.The 8th day sacrificed by decapitation white mice that all survives, cuts open inspection, one by one the variation of observed and recorded internal organs.

The mensuration of median lethal dose(LD 50): according to the number of elements of each dosage treated animal death, calculate the median lethal dose(LD 50) of the granule 1 of the embodiment of the present invention 1 preparation.

5.2.4 result

Clinical manifestation: 14.4g/kg body weight dosage group has 1 mice dead immediately after administration, cuts open inspection and sees that stomach expands, and gastric is full of medicine, all the other organ-tissues, the heart, liver, spleen, lung, kidney and intestinal are without observing variation.There is few moving after having 2 mice lavages in 10.3g/kg body weight dosage group, spirit is depressed, observes transference cure after 4h.All the other each dosage group mices all survive, and compare with blank group, drink water, search for food, the mental status, active situation and defecation etc. compare with blank group without abnormal.

Substantially cuing open inspection changes: within the 8th day, catch and kill whole survival mice, cut open each organ-tissue of each dosed administration group mice of inspection, the heart, liver,spleen,kidney, harmonization of the stomach intestinal and blank group mice organize the internal organs no significant difference of comparing.

It is dead that maximum dose level group (14.4g/kg body weight) has 1 white mice to occur after administration, cuts open the visible stomach of inspection and expand, and gastric is full of medicine, and all the other organ-tissues after one's own heart, liver, spleen, lung, kidney and intestinal etc. are showed no ANOMALOUS VARIATIONS.Show that this dosage has exceeded the stomach volume of this mice, cause mice dying, but not drug intoxication is dead.10.3g/kg body weight group has 2 mices to occur few moving, spiritual depressed situation, may too much cause because dosage causes greatly its gastric content, after 4h, observe this mice transference cure, illustrate that mice does not produce further toxic reaction to the medicine of this dosage.All the other are respectively organized the searching for food of mice, drinking-water, mental status active situation and defecation etc. and compare with blank group without abnormal.The acute toxicity that Chinese medicine of the present invention is described is low.The gross anatomy structure of each dosed administration group white mice and internal organs are that the heart, liver,spleen,kidney, harmonization of the stomach intestinal are compared and are showed no notable difference with blank group.Illustrate that Chinese medicine of the present invention does not produce obvious toxic reaction to the internal organs of mice.

According to < < veterinary drug test requirement specification compilation > > regulation, when reaching 14.4g/kg body weight, dosage do not occur yet that white mice toxic is dead, the toxicity that shows medicine is low, can obtain median lethal dose(LD 50).This test shows that the acute toxicity of Chinese medicine of the present invention is extremely low.

Embodiment 6 zooprophylazis influenza virus tests

Laboratory animal instrument: mice, female, 13～15g, Qingdao City's Experimental Animal Center provides, SPF level; Ether, Guangzhou Chemical Reagent Factory provides, ribavirin injection, by Qingdao, pharmaceutical factory provides; 402AI medical ultrasonic atomizer, Qingdao Hui Tian armarium company limited provides.FA1004 type electronic analytical balance, the flat instrument and meter of upper current chart company limited provides; Superpure water machine (millipore), ultralow warm water, is provided by Sanyo Japan.

Experiment virus and medicine:

Virus: influenza virus A/FM/1/47 (H1N1) Mus lung adapted strain, by Inst. of Medicinal Biological Technology, Chinese Academy of Medical Sciences, provided, the freezing preservation in Inst. of Tropical Medicine, Guangzhou Chinese Medicine College Viral Laboratory, in Madin-Darby canine kidney(cell line) (MDCK) (MDCK), go down to posterity, with cytopathy and chicken erythrocyte Hemagglutination Method, judge its titre.

Medicine: the 1. granule 1 that prepared by the embodiment of the present invention 1, in water, obtains the outstanding mixed liquid of 3g/ml (crude drug concentration) by granule heating for dissolving; 2. ribavirin injection.

Method

Different prevention sides medicine suppresses the comparison of influenza virus effect: under the slight anesthesia of ether, and collunarium influenza virus infection liquid, 4 of every Mus, about 0.05ml.Trial drug administration one week before infect attacking prerequisite, continues administration 5d after attacking, and adopts oral prevention administration.Be total to administration 12d, every day 1 time, the granule dosage 1 every day of the embodiment of the present invention 1 preparation is 10g/kg (crude drug amount), and ribavirin dosage is 100mg/kg every day.5d after infecting, kills and cuts open mice, weighs and resurveys and determine lung index with lung.

The comparison of the dead protective effect of different prevention sides medicine infected by influenza infected mice: trial drug adopts oral prevention approach to give medicine one week, and except negative control group, all the other each experimental grouies are all through etherization; under the slight anesthesia of ether; collunarium influenza virus infection liquid, 4 of every Mus, about 0.05ml.Virus control group adopts and gives same volume distilled water (containing 0.5% tween 80).After viral infection, stop administration, observe 2 weeks, record death time of animal, death toll, calculate mortality rate, mean survival time, the granule dosage 1 every day of the embodiment of the present invention 1 preparation is 10g/kg (crude drug amount), and ribavirin dosage is 100mg/kg every day.

Statistical procedures: adopt SPSS18.0 to carry out data statistics, lung index level value, mean survival time adopt one factor analysis of variance, and mortality rate adopts χ ²check.Inspection level a=0.05.

Result:

Different prevention sides medicine suppresses the comparison that influenza virus lung recast is used

The viral pneumonia of influenza virus collunarium infecting mouse, mainly causes that lung tissue occurs take that monocyte infiltration is as main inflammation performance.The inflammation of infected mice lung oozes out, the being proportionate property of light and heavy degree of congested, blood stasis pathological changes and its viral infection, pulmonary inflammatory formation certainly will cause the increase that lung is heavy and the body weight of virus infected mice often reduces, therefore in resisiting influenza virus body, evaluating drug effect passes judgment on pharmaceutically-active index with the percentage rate of the heavy percentage of liveweight of mouse lung mainly with lung exponential quantity, the results are shown in Table 1.

The inhibitory action of table 1 Chinese herb on the prevention administration to H1N1 influenza a virus infection mice

Note: compare *: P<0.05, * *: P<0.01 with virus control group; Lung index=(mouse lung weight/Mouse Weight) * 100; Lung index=(virus control group lung Mean value of index-experimental group lung Mean value of index)/virus control group lung Mean value of index * 100; Dead protective rate=(matched group mortality rate-administration group mortality rate) * 100.

Conclusion: more each Experimental agents group infected mice lung is heavy is and alleviates degree than virus control group.The lung index index of consideration whose body weight variance factor impact difference has statistically significant.The lung index of Chinese medicine granules of the present invention reaches more than 35%.

Different prevention sides medicine infected by influenza infected mice living or death situation

Mouse infection influenza virus A 1 type, model group morbidity after 5d, is not found obvious difference mostly, and infecting mouse occurs alarmming hair, crispaturas, and hair is matt, movable minimizing, appetite reduces, and loses weight, and exhaustion is dead gradually.Virus control group is greatly more than 6th～10d Large Scale Death.By comparison, medication is respectively organized most symptoms and is alleviated, and a few symptoms weight is finally dead.Each Experimental agents group shifts to an earlier date administration 7d, and after influenza virus infection, each treated animal living or death situation (table 1) is observed in drug withdrawal.Negative control group uninfecting virus, without animal dead.All dead within viral infection matched group 15d, mortality rate is 100%.Ribavirin is 50% to the dead protective rate of infected mice, compares with viral infection matched group, and difference has significance,statistical meaning (P<0.05).Chinese medicine granules of the present invention is 90% to the dead protective rate of infected mice, compares with virus control group, and difference has significance,statistical meaning (P<0.05), and is starkly lower than ribavirin group.

Different prevention side's medicine infected by influenza infected mice mean survival time comparisons, the results are shown in Table 2.

Each treated animal life span of preventive effect that table 2 Chinese medicine infects Mus influenza virus H1N1

Group	Dosage (g/kg)	Mean survival time (d)	Extending life rate (%)
				Negative control group	-	15.00±0.00**	-
Virus control group	-	7.60±1.50	-
				Ribavirin group	0.1	11.11±3.78*	46.18
Chinese medicine granules group	10	13.40±2.05**	76.31

Note: compare *: P<0.05, * *: P<0.01 with virus control group; A): if exceed 15d, still died is not in 15d, and within 2d, died is disregarded.B): extending life rate=(investigational agent group life span average-virus control group life span average)/virus control group life span average * 100

Conclusion: as can be seen from Table 2, the viral infection matched group Mus mean survival time is in 7.6d left and right.And all there is prolongation in various degree each trial drug group Mus mean survival time, greatly about 11～13.4d left and right.Ribavirin extends Mus vital rates below 50%, and Chinese medicine granules of the present invention reaches 76.31%, compares with virus control group, and difference has significance,statistical meaning (P<0.01～0.05).

Embodiment 7 clinical datas

Physical data: participating in testing crew is the community resident of Qingdao City totally 1796 examples, 18～60 years old age.Be divided at random Chinese drug-treated group 926 examples, blank group 870 examples.2 groups of residents' sex, influenza incidence comparing difference not statistically significant (P > 0.05) in first 1 month, have comparability, Chinese drug-treated group man 413 examples wherein, female's 513 examples, blank group man 329 examples, female's 541 examples.

Influenza diagnostic criteria: this test was carried out in the influenza high-incidence season (winter-spring season), according to epidemiology statistics, the influenza 80%～95% during this is swine flu, take and generates heat as cardinal symptom.Selected personnel are student healthy, collective livelihood, therefore there is heating, pharyngalgia, watery nasal discharge, nasal obstruction, cough, cough up phlegm, headache, systemic pain, the influenza-like symptom such as weak all can think influenza.

Subject's selection and rejecting:

Inclusion criteria: in Yi Ge colony community life and in first 1 month not heating personnel.Exclusion standard: first 1 month troubles is crossed the personnel of influenza.Rejecting standard: fail to use on request personnel medicine or that leave group life midway.

Prevention method: Chinese drug-treated group oral 5g embodiment 1 every day prepares Chinese medicine granules 1, is dissolved in hot water, oral, takes blank group 3 months: do not do any chemoprophylaxis measure.

Observational technique: observe experimenter's body temperature and whether occur flu-like symptom, observing and have no adverse reaction simultaneously.Evaluation criteria: measure selected personnel's body temperature record every day.Do not generate heat: 37 ℃ of body temperature <; Low grade fever: body temperature is between 37～38 ℃; High heat: 38 ℃ of body temperature > and persistent period > 3d.

Safety criterion:

1 grade: safety, without any untoward reaction; 2 grades: safer, if any untoward reaction, do not need to do any processing and can continue medication; 3 grades: have safety problem, have moderate untoward reaction, after processing, can continue medication; 4 grades: because of untoward reaction discontinue medication.

Statistical analysis: adopt SPSS18.0 to carry out data statistics, enumeration data adopts χ ²check, P < 0.05 has statistical significance for difference.

Result

Safety is judged: the Chinese medicine granules of the embodiment of the present invention 1 preparation, in medication process, is not found untoward reaction, and safety is judged to be 1 grade.

Before and after prevention, heating relatively, the results are shown in Table 3.

Heating comparative example (%) before and after table 32 group personnel prevent

As can be seen from Table 3, by the prevention of Chinese medicine granules of the present invention, Chinese drug-treated group personnel's incidence will be significantly less than blank group.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. for preventing a grippal Chinese medicine, it is characterized in that: the crude drug of described Chinese medicine comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

2. Chinese medicine as claimed in claim 1, is characterized in that: in described Chinese medicine, the weight portion of each crude drug is respectively Folium Isatidis 75 weight portion～85 weight portions, Radix Sophorae Tonkinensis 35 weight portion～45 weight portions, Herba Moslae 20 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Platycodonis 20 weight portion～30 weight portions, Herba Abri 35 weight portion～45 weight portions, Herba Artemisiae Annuae 25 weight portion～35 weight portions, Folium Ginseng 45 weight portion～55 weight portions, the Radix Angelicae Dahuricae 30 weight portion～40 weight portions, the Rhizoma Anemarrhenae 40 weight portion～50 weight portions, Rhizoma Paridis 20 weight portion～30 weight portions, Fructus Arctii 25 weight portion～35 weight portions, Flos Caryophylli 15 weight portion～25 weight portions, Herba Senecionis Scandentis 25 weight portion～35 weight portions, Rhizoma Imperatae 30 weight portion～40 weight portions, Rhizoma Dryopteris Crassirhizomatis 45 weight portion～55 weight portions, Radix Et Rhizoma Rhei 30 weight portion～40 weight portions, Radix Bupleuri 25 weight portion～35 weight portions, Radix Berberidis 30 weight portion～40 weight portions, Semen Glycine Germinatum 20 weight portion～30 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions, Flos Lonicerae 30 weight portion～40 weight portions, Concretio Silicea Bambusae 40 weight portion～50 weight portions, Coriolous Dersicolor (Fr.) Quel 20 weight portion～30 weight portions, Rhizoma Ligustici 25 weight portion～35 weight portions and Herba Epimedii 35 weight portion～45 weight portions.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine, the weight portion of each crude drug is respectively Folium Isatidis 80 weight portions, Radix Sophorae Tonkinensis 40 weight portions, Herba Moslae 25 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Platycodonis 25 weight portions, Herba Abri 40 weight portions, Herba Artemisiae Annuae 30 weight portions, Folium Ginseng 50 weight portions, the Radix Angelicae Dahuricae 35 weight portions, the Rhizoma Anemarrhenae 45 weight portions, Rhizoma Paridis 25 weight portions, Fructus Arctii 30 weight portions, Flos Caryophylli 20 weight portions, Herba Senecionis Scandentis 30 weight portions, Rhizoma Imperatae 35 weight portions, Rhizoma Dryopteris Crassirhizomatis 50 weight portions, Radix Et Rhizoma Rhei 35 weight portions, Radix Bupleuri 30 weight portions, Radix Berberidis 35 weight portions, Semen Glycine Germinatum 25 weight portions, Rhizoma Dioscoreae 40 weight portions, Flos Lonicerae 35 weight portions, Concretio Silicea Bambusae 45 weight portions, Coriolous Dersicolor (Fr.) Quel 25 weight portions, Rhizoma Ligustici 30 weight portions and Herba Epimedii 40 weight portions.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that: the dosage form of described Chinese medicine is granule and tablet.

5. the preparation method of Chinese medicine described in claim 1 to 4, is characterized in that: when the dosage form of described Chinese medicine is granule, concrete steps are,

6. the preparation method of Chinese medicine described in claim 1 to 4, is characterized in that: when the dosage form of described Chinese medicine is tablet, concrete steps are,

7. for preventing a grippal Chinese medicine granules, it is characterized in that: the crude drug of described Chinese medicine granules comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

8. for preventing a grippal Chinese medicinal tablet, it is characterized in that: the crude drug of described Chinese medicinal tablet comprises Folium Isatidis, Radix Sophorae Tonkinensis, Herba Moslae, Radix seu Herba Gei aleppici, Radix Platycodonis, Herba Abri, Herba Artemisiae Annuae, Folium Ginseng, the Radix Angelicae Dahuricae, the Rhizoma Anemarrhenae, Rhizoma Paridis, Fructus Arctii, Flos Caryophylli, Herba Senecionis Scandentis, Rhizoma Imperatae, Rhizoma Dryopteris Crassirhizomatis, Radix Et Rhizoma Rhei, Radix Bupleuri, Radix Berberidis, Semen Glycine Germinatum, Rhizoma Dioscoreae, Flos Lonicerae, Concretio Silicea Bambusae, Coriolous Dersicolor (Fr.) Quel, Rhizoma Ligustici and Herba Epimedii.

Described in claim 1 to 4 Chinese medicine in the application in grippal medicament for the preparation of prevention.