CN106177992A - cMLCK基因导入 - Google Patents

cMLCK基因导入 Download PDF

Info

Publication number
CN106177992A
CN106177992A CN201510232415.6A CN201510232415A CN106177992A CN 106177992 A CN106177992 A CN 106177992A CN 201510232415 A CN201510232415 A CN 201510232415A CN 106177992 A CN106177992 A CN 106177992A
Authority
CN
China
Prior art keywords
cmlck
certain embodiment
seq
polynucleotide
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510232415.6A
Other languages
English (en)
Chinese (zh)
Inventor
周明东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zensun Shanghai Science and Technology Ltd
Original Assignee
Zensun Shanghai Science and Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zensun Shanghai Science and Technology Ltd filed Critical Zensun Shanghai Science and Technology Ltd
Priority to CN201510232415.6A priority Critical patent/CN106177992A/zh
Priority to CN202010310166.9A priority patent/CN111388682A/zh
Priority to BR112017024065-3A priority patent/BR112017024065A2/pt
Priority to AU2016260473A priority patent/AU2016260473A1/en
Priority to KR1020177032419A priority patent/KR20190008511A/ko
Priority to CA2985396A priority patent/CA2985396A1/en
Priority to CN201680025125.7A priority patent/CN107735109A/zh
Priority to EP16792227.7A priority patent/EP3295959A4/en
Priority to RU2017142779A priority patent/RU2017142779A/ru
Priority to US15/572,467 priority patent/US20180133291A1/en
Priority to JP2017558467A priority patent/JP2018515510A/ja
Priority to PCT/CN2016/085699 priority patent/WO2016180377A1/zh
Publication of CN106177992A publication Critical patent/CN106177992A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11018—Myosin-light-chain kinase (2.7.11.18)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
CN201510232415.6A 2015-05-08 2015-05-08 cMLCK基因导入 Pending CN106177992A (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201510232415.6A CN106177992A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
CN202010310166.9A CN111388682A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
BR112017024065-3A BR112017024065A2 (pt) 2015-05-08 2016-06-14 método para tratar insuficiência cardíaca avançada em um indivíduo humano
AU2016260473A AU2016260473A1 (en) 2015-05-08 2016-06-14 cMLCK gene introduction
KR1020177032419A KR20190008511A (ko) 2015-05-08 2016-06-14 cMLCK 유전자 이식
CA2985396A CA2985396A1 (en) 2015-05-08 2016-06-14 Cmlck gene transfer
CN201680025125.7A CN107735109A (zh) 2015-05-08 2016-06-14 cMLCK基因导入
EP16792227.7A EP3295959A4 (en) 2015-05-08 2016-06-14 Cmlck gene introduction
RU2017142779A RU2017142779A (ru) 2015-05-08 2016-06-14 Перенос гена cmlck
US15/572,467 US20180133291A1 (en) 2015-05-08 2016-06-14 Cmlck gene transfer
JP2017558467A JP2018515510A (ja) 2015-05-08 2016-06-14 ｃＭＬＣＫ遺伝子導入
PCT/CN2016/085699 WO2016180377A1 (zh) 2015-05-08 2016-06-14 cMLCK基因导入

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510232415.6A CN106177992A (zh) 2015-05-08 2015-05-08 cMLCK基因导入

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010310166.9A Division CN111388682A (zh) 2015-05-08 2015-05-08 cMLCK基因导入

Publications (1)

Publication Number Publication Date
CN106177992A true CN106177992A (zh) 2016-12-07

Family

ID=57247711

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201510232415.6A Pending CN106177992A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
CN202010310166.9A Pending CN111388682A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
CN201680025125.7A Pending CN107735109A (zh) 2015-05-08 2016-06-14 cMLCK基因导入

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202010310166.9A Pending CN111388682A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
CN201680025125.7A Pending CN107735109A (zh) 2015-05-08 2016-06-14 cMLCK基因导入

Country Status (10)

Country Link
US (1) US20180133291A1 (enExample)
EP (1) EP3295959A4 (enExample)
JP (1) JP2018515510A (enExample)
KR (1) KR20190008511A (enExample)
CN (3) CN106177992A (enExample)
AU (1) AU2016260473A1 (enExample)
BR (1) BR112017024065A2 (enExample)
CA (1) CA2985396A1 (enExample)
RU (1) RU2017142779A (enExample)
WO (1) WO2016180377A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107735109A (zh) * 2015-05-08 2018-02-23 上海泽生科技开发股份有限公司 cMLCK基因导入

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
BR112015006656A8 (pt) 2012-10-08 2020-01-21 Sensun Shanghai Science & Tech Co Ltd composições e métodos para o tratamento de insuficiência cardíaca em pacientes diabéticos
CN115838437A (zh) * 2022-11-04 2023-03-24 广州达安基因股份有限公司 人NT-proBNP融合蛋白及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009242388A (ja) * 2008-03-14 2009-10-22 National Cardiovascular Center 心臓特異的キナーゼの心不全診断および治療への応用
CN102618562A (zh) * 2006-08-21 2012-08-01 上海泽生科技开发有限公司 生长因子神经调节蛋白的下游蛋白纽激酶

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001290864A1 (en) * 2000-09-12 2002-04-02 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Optimized cardiac contraction through differential phosphorylation of myosin
CN102416184A (zh) * 2011-12-08 2012-04-18 哈尔滨医科大学 microRNA-1的反义锁核苷酸序列在制备预防或治疗心肌梗死后心衰药物中的应用
CN106177992A (zh) * 2015-05-08 2016-12-07 上海泽生科技开发有限公司 cMLCK基因导入

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102618562A (zh) * 2006-08-21 2012-08-01 上海泽生科技开发有限公司 生长因子神经调节蛋白的下游蛋白纽激酶
JP2009242388A (ja) * 2008-03-14 2009-10-22 National Cardiovascular Center 心臓特異的キナーゼの心不全診断および治療への応用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107735109A (zh) * 2015-05-08 2018-02-23 上海泽生科技开发股份有限公司 cMLCK基因导入

Also Published As

Publication number Publication date
BR112017024065A2 (pt) 2018-08-07
RU2017142779A3 (enExample) 2019-12-03
CN111388682A (zh) 2020-07-10
CN107735109A (zh) 2018-02-23
EP3295959A1 (en) 2018-03-21
CA2985396A1 (en) 2016-11-17
AU2016260473A1 (en) 2017-12-21
JP2018515510A (ja) 2018-06-14
US20180133291A1 (en) 2018-05-17
EP3295959A4 (en) 2019-01-02
WO2016180377A1 (zh) 2016-11-17
RU2017142779A (ru) 2019-06-10
KR20190008511A (ko) 2019-01-24

Similar Documents

Publication Publication Date Title
AU2007221470B2 (en) Phosphatase inhibitor Protein-1 as a regulator of cardiac function
Yan et al. Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of transforming growth factor-β/Smad and p38 mitogen-activated protein kinase signaling pathways
CA2513249A1 (en) Method for in vivo regulation of cardiac muscle contractility
CN106177992A (zh) cMLCK基因导入
JP2025107171A (ja) 心臓保護的活性のあるタンパク質
EA005157B1 (ru) Методы и составы для лечения сердечной недостаточности и вентрикулярной коррекции путем доставки in vivo ангиогенных трансгенов
US20090105148A1 (en) Compositions and methods for treating myocardial infarction
US20180099029A9 (en) Serca2 therapeutic compositions and methods of use
US20070265221A1 (en) Methods to improve creatine kinase metabolism and contractile function in cardiac muscle for the treatment of heart failure
WO2020176732A1 (en) TREATMENT OF PULMONARY FIBROSIS WITH SERCA2a GENE THERAPY
CN115820740A (zh) 用于治疗ⅱ型粘多糖贮积症的重组腺相关病毒载体及其应用
KR20230035584A (ko) Dwarf 개방 판독 프레임을 위한 아데노-관련 바이러스 벡터
EP4410988A1 (en) An aav2-vector variant for targeted transfer of genes
US20230250450A1 (en) NRF2 Activator for Use in Treating Dilated Cardiomyopathies
Nguyen The Cardioprotective Role of Prolyl Carboxypeptidase (PRCP) in Cardiac Hypertrophic Remodelling
KR100697321B1 (ko) ＶＥＧＦ－Ａ, ＶＥＧＦ－Ｂ 및 ＶＥＧＦ－Ｃ의 안티센스ｃＤＮＡ를 함유하는 재조합 아데노-연관바이러스（ｒＡＡＶ） 및 이를 함유하는 대장암, 방광암및/또는 폐암 특이적 유전자 치료제
CN118416257A (zh) Mif基因在制备治疗和/或预防心肌缺血损伤的药物中的应用、载体和药物
HK40014345A (en) Peptides having specificity for the lungs
Lai et al. 835. Long-Term Clinical Findings and Toxicity in MPS VII Mice Injected Intravenously at Birth with an Adeno-Associated Virus Vector
US20120142762A1 (en) Method for Preventing and Treating Cardiovascular Diseases with BRCA1
HK1129392A (en) Phosphatase inhibitor protein-1 as a regulator of cardiac function

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
CB02 Change of applicant information
CB02 Change of applicant information

Address after: 201203 Shanghai Curie road in Pudong New Area Zhangjiang hi tech Park No. 68

Applicant after: ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY, Co.,Ltd.

Address before: 201203 Shanghai Curie road in Pudong New Area Zhangjiang hi tech Park No. 68

Applicant before: ZENSUN (SHANGHAI) SCIENCE & TECHNOLOGY Ltd.

SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20161207