KR20190008511A - cMLCK 유전자 이식 - Google Patents

cMLCK 유전자 이식 Download PDF

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Publication number
KR20190008511A
KR20190008511A KR1020177032419A KR20177032419A KR20190008511A KR 20190008511 A KR20190008511 A KR 20190008511A KR 1020177032419 A KR1020177032419 A KR 1020177032419A KR 20177032419 A KR20177032419 A KR 20177032419A KR 20190008511 A KR20190008511 A KR 20190008511A
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KR
South Korea
Prior art keywords
leu
cmlck
glu
gly
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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KR1020177032419A
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English (en)
Korean (ko)
Inventor
밍동 쪼우
Original Assignee
젠순 (상하이) 사이언스 앤드 테크놀로지 캄파니 리미티드
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Publication of KR20190008511A publication Critical patent/KR20190008511A/ko
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45Transferases (2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11018Myosin-light-chain kinase (2.7.11.18)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
KR1020177032419A 2015-05-08 2016-06-14 cMLCK 유전자 이식 Withdrawn KR20190008511A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510232415.6A CN106177992A (zh) 2015-05-08 2015-05-08 cMLCK基因导入
PCT/CN2016/085699 WO2016180377A1 (zh) 2015-05-08 2016-06-14 cMLCK基因导入

Publications (1)

Publication Number Publication Date
KR20190008511A true KR20190008511A (ko) 2019-01-24

Family

ID=57247711

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177032419A Withdrawn KR20190008511A (ko) 2015-05-08 2016-06-14 cMLCK 유전자 이식

Country Status (10)

Country Link
US (1) US20180133291A1 (enExample)
EP (1) EP3295959A4 (enExample)
JP (1) JP2018515510A (enExample)
KR (1) KR20190008511A (enExample)
CN (3) CN111388682A (enExample)
AU (1) AU2016260473A1 (enExample)
BR (1) BR112017024065A2 (enExample)
CA (1) CA2985396A1 (enExample)
RU (1) RU2017142779A (enExample)
WO (1) WO2016180377A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun (Shanghai)Science & Technology Limited Compositions and methods for treating heart failure
RU2650635C2 (ru) 2012-10-08 2018-04-16 Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи, Ко., Лтд. Композиции и способы лечения сердечной недостаточности у пациентов с диабетом
CN111388682A (zh) * 2015-05-08 2020-07-10 上海泽生科技开发股份有限公司 cMLCK基因导入
CN115838437A (zh) * 2022-11-04 2023-03-24 广州达安基因股份有限公司 人NT-proBNP融合蛋白及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001290864A1 (en) * 2000-09-12 2002-04-02 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Optimized cardiac contraction through differential phosphorylation of myosin
US9580515B2 (en) * 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
JP2009242388A (ja) * 2008-03-14 2009-10-22 National Cardiovascular Center 心臓特異的キナーゼの心不全診断および治療への応用
CN102416184A (zh) * 2011-12-08 2012-04-18 哈尔滨医科大学 microRNA-1的反义锁核苷酸序列在制备预防或治疗心肌梗死后心衰药物中的应用
CN111388682A (zh) * 2015-05-08 2020-07-10 上海泽生科技开发股份有限公司 cMLCK基因导入

Also Published As

Publication number Publication date
BR112017024065A2 (pt) 2018-08-07
CN107735109A (zh) 2018-02-23
AU2016260473A1 (en) 2017-12-21
CA2985396A1 (en) 2016-11-17
WO2016180377A1 (zh) 2016-11-17
JP2018515510A (ja) 2018-06-14
RU2017142779A3 (enExample) 2019-12-03
RU2017142779A (ru) 2019-06-10
CN111388682A (zh) 2020-07-10
EP3295959A4 (en) 2019-01-02
US20180133291A1 (en) 2018-05-17
CN106177992A (zh) 2016-12-07
EP3295959A1 (en) 2018-03-21

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20171108

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination