CN106177867A - 一种治疗慢性肾炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物包括如下原料药材：姜、红枣、桂圆、红糖、枸杞、丹参、益母草。该中药组合物原料药材来源广，廉价易得，配方合理，治疗慢性肾炎疗效显著。
Description
技术领域
本发明属于中医中药制剂领域，具体涉及一种治疗慢性肾炎的中药组合物。
背景技术
慢性肾炎是慢性肾小球肾炎的简称，是一种常见而难治的慢性肾脏疾患。临床以水肿、蛋白尿、血尿、高血压为特征，本病多发生于青壮年，是机体对溶血性键球菌感染后发生的变态反应性疾病，病变常常是双侧肾脏弥漫性病变。慢性肾病的主要表现有：(1)水肿；(2)高血压；(3)肾区疼痛及肾绞痛；(4)尿路刺激征(即尿急、尿痛、尿频)；(5)排尿异常(包括尿量减少、蛋白尿、血尿、管型尿、白细胞尿、脓尿和菌尿、肾功能试验阳性等。慢性肾病如未能及时有效救治，导致病情恶化进展，则随病程迁延，慢性肾病患者将发展成为慢性肾功能不全、肾衰竭，最终形成尿毒症。
目前西医临床上常用透析及肾脏移植等疗法，透析只能维持生命，而且产生依赖性和透析综合症，肾移植成功率低，而排斥现象一时还难以解决，激素疗法副作用明显，且易复发，加之透析和肾移植的费用昂贵往往使众多的患者难以承受。
慢性肾炎在发展到肾衰之前有很长的一段时间，这个阶段积极治疗，采用中医药进行调理，安全有效又经济，还能取得相对西医更好的疗效，可以说中医药对治疗慢性肾炎是很有优势的。
中医治疗慢性肾炎采用扶正以祛邪和祛邪以安正两大法则为治疗的原则。慢性肾炎的发生、复发、迁延不愈，与某些细菌或病毒感染有关。因此，有效地控制感染是促使病情痊愈和预防复发的关键，清热解毒类的中草药具有较强的抗感染作用。所以，中医临床治疗慢性肾炎时，常在健脾益肾的基础上加一些清热解毒或活血化淤药物，以提高临床疗效。
发明内容
本发明旨在提供一种治疗慢性肾炎的中药组合物。
为实现上述发明目的，本发明一种治疗慢性肾炎的中药组合物，具体实施方案为：
本发明所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物包括如下原料药材：姜、红枣、桂圆、红糖、枸杞、丹参、益母草。
本发明所述一种治疗慢性肾炎的中药组合物，该中药组合物处方重量份数计为：姜、红枣、桂圆各10-20份，枸杞、丹参各5-15份，红糖、益母草各15-30份。
本发明所述一种治疗慢性肾炎的中药组合物，该中药组合物处方重量份数计为：姜、红枣、桂圆各15份，枸杞、丹参各10份，红糖、益母草各20份。
本发明所述备方法包括以下步骤：
1）按中药组方分别称取各味药材，洗去杂质，干燥后分别粉碎，过60-80目筛，备用；
2）取姜、红枣、桂圆、红糖、枸杞、丹参、益母草粗粉，加入药材总量5-10倍量的水浸泡1-3小时，然后煎煮1-4次，每次1-2小时，过滤并保留滤渣，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得水提浓缩液；
3）往步骤2）中的滤渣中加入药材总量5-10倍量体积分数为60-80%的乙醇，回流提取2-3次，过滤，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得醇提浓缩液；
4）合并步骤2）和3)浓缩液，干燥，将浸膏粉碎，制剂。
本发明所述一种治疗慢性肾炎的中药组合物，该中药组合物制剂可以为颗粒剂、片剂、胶囊剂、贴剂、丸剂。
本发明所述一种治疗慢性肾炎的中药组合物，该中药组合物制剂在治疗慢性肾炎中的应用。
本发明所述一种治疗慢性肾炎的中药组合物，该中药组合物制剂主要原料药在治疗慢性肾炎中的应用。
本发明各组分分析：
姜：辛,微温。归肺、脾经。生姜功效:发汗解表,温中止吐,温肺止咳。
红枣：甘,温。归脾、胃经。大枣功效:补中益气,养血安神,缓和药性。
桂圆：甘、辛,温。归肝、心、脾经。补心安神,养血益脾。
红糖：甘甜、温润、无毒。入肝、脾。润心肺,和中助脾。
枸杞：甘,平，归肝、肾经。滋补肝肾,益精明目。
丹参：苦,微寒。归心、心包、肝经。活血祛瘀,凉血消痈,养血安神。
益母草：辛、苦、微寒。归心、肝、膀胱经。活血化瘀,利水消肿。
本发明组方分析：
本发明选用枸杞滋补肝肾，选用红枣、桂圆补中益气, 养血益脾，选用姜、红糖温肺，丹参、益母草活血祛瘀、利水消肿，本发明中药制剂具有滋补肝肾、固本培元的功效，是治疗慢性肾炎的内服纯中草药组成制剂。 通过姜、红枣、桂圆、红糖、枸杞、丹参、益母草等原料药中君、臣、佐、使之间的协同作用，相得益彰，在固本培元的同时，可以使得患者毒素有效排除，从而达到泄浊清热解毒、通腑泻浊、利水、滋阴补肾的功效。
具体实施方式
下面实施例只为进一步说明本发明，不以任何形式限制本发明范围。
实施例1
处方：姜、红枣、桂圆各15份，枸杞、丹参各10份，红糖、益母草各20份。
实施例2
处方：姜、红枣、桂圆各20份，枸杞、丹参各10份，红糖、益母草各30份。
实施例3
处方：姜、红枣、桂圆各18份，枸杞、丹参各12份，红糖、益母草各25份。
实施例4
处方：姜、红枣、桂圆各20份，枸杞、丹参各15份，红糖、益母草各20份。
实施例1-4制剂制备方法：
1）按中药组方分别称取各味药材，洗去杂质，干燥后分别粉碎，过60-80目筛，备用；
2）取姜、红枣、桂圆、红糖、枸杞、丹参、益母草粗粉，加入药材总量8倍量的水浸泡2小时，然后煎煮2次，每次1-2小时，过滤并保留滤渣，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得水提浓缩液；
3）往步骤2）中的滤渣中加入药材总量6倍量体积分数为60-80%的乙醇，回流提取2次，过滤，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得醇提浓缩液；
4）合并步骤2）和3)浓缩液，干燥，将浸膏粉碎，制剂（颗粒剂、片剂、胶囊剂、贴剂、丸剂）。
临床资料：
随机抽取临床慢性肾炎病例100例，年龄从25-65不等，平均年龄40岁，服用本发明实施例1颗粒剂，一次一袋，一日三次，15天为一个疗程。
疗效诊断标准：
治愈：水肿、尿少、血尿、高血压等症状全消失；显效：水肿、尿少、血尿、高血压等症状显著减轻；有效：水肿、尿少、血尿、高血压等症状改善，血清尿素氮、肌酐清除率稳定，尿常规在正常范围值；无效：症状、体征未见明显改善，甚至恶化或转手术治疗。
上述患者服用本发明颗粒剂5-8个疗程后，治愈5，显效28，有效41，无效26，本发明对治疗慢性肾炎总有效率74%。
Claims (7)
1.一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物包括如下原料药材：姜、红枣、桂圆、红糖、枸杞、丹参、益母草。
2.根据权利要求1所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物处方重量份数计为：姜、红枣、桂圆各10-20份，枸杞、丹参各5-15份，红糖、益母草各15-30份。
3.根据权利要求1所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物处方重量份数计为：姜、红枣、桂圆各15份，枸杞、丹参各10份，红糖、益母草各20份。
4.根据权利要求1所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物制剂制备方法包括以下步骤：
1）按中药组方分别称取各味药材，洗去杂质，干燥后分别粉碎，过60-80目筛，备用；
2）取姜、红枣、桂圆、红糖、枸杞、丹参、益母草粗粉，加入药材总量5-10倍量的水浸泡1-3小时，然后煎煮1-4次，每次1-2小时，过滤并保留滤渣，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得水提浓缩液；
3）往步骤2）中的滤渣中加入药材总量5-10倍量体积分数为60-80%的乙醇，回流提取2-3次，过滤，合并滤液，滤液真空减压浓缩至60℃条件下测相对密度为1.05-1.15的浓缩液，得醇提浓缩液；
4）合并步骤2）和3)浓缩液，干燥，将浸膏粉碎，制剂。
5.根据权利要求1-5任一项所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物制剂可以为颗粒剂、片剂、胶囊剂、贴剂、丸剂。
6.根据权利要求6所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物制剂在治疗慢性肾炎中的应用。
7.根据权利要求7所述一种治疗慢性肾炎的中药组合物，其特征在于，该中药组合物制剂主要原料药在治疗慢性肾炎中的应用。
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