CN106177642A - 一种治疗类风湿性关节炎的内服药物及其制备方法 - Google Patents

一种治疗类风湿性关节炎的内服药物及其制备方法 Download PDF

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CN106177642A
CN106177642A CN201610869839.8A CN201610869839A CN106177642A CN 106177642 A CN106177642 A CN 106177642A CN 201610869839 A CN201610869839 A CN 201610869839A CN 106177642 A CN106177642 A CN 106177642A
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radix
rhizoma
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rheumatoid arthritis
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罗娟
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Chengdu Feilong Water Treatment Technology Institute
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Abstract

本发明属于中医药技术领域,目的是根据中医对类风湿性关节炎的认识机理而提供的一种治疗类风湿性关节炎的内服药物,所述药物的各个组分及其质量份比如下:桑寄生10~15g、炙甘草2~11g、九节菖蒲4~8g、党参15~25g、熟地黄10~32g、杜仲(盐制)15~26g、白芍10~23g、防风5~10g、当归8~16g、牛膝5~16g、秦艽5~12g、茯苓15~26g、独活5~16g、桂枝2~8g、川芎5~10g、葛根10~16g、薏苡仁15~45g、泽泻6~10g、威灵仙6~9g、赤芍6~12g、防己5~10g、木瓜8~16g、麻黄2~10g、苍术(炒)3~10g、丝瓜络5~16g;本发明提供的药物是一个很好的中药组方。

Description

一种治疗类风湿性关节炎的内服药物及其制备方法
技术领域
本发明涉及中医药技术领域,具体涉及一种治疗类风湿性关节炎的内服药物,特别是供类风湿性关节炎患者使用的内服药物及其制备方法的领域。
背景技术
类风湿性关节炎是一种以关节病变为主的慢性全身自身免疫性疾病。主要临床表现为:小关节滑膜所致的关节肿痛,继而软骨破坏、关节间隙变窄,晚期因严重骨质破坏、吸收导致关节僵直、畸形、功能障碍。在我国类风湿性关节炎的患病率为0.24-0.5%,女性多于男性,约2~3:1,任何年龄均可发病,以20~50岁最多。本病多为一种反复发作性疾病,致残率较高,预后不良,就目前而言,还没有很好的根治方法。
那么,就如何找到一种可有效治疗类风湿性关节炎的药物,是我们目前急需要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗类风湿性关节炎上,人们逐渐意识到了中医治疗上述类风湿性关节炎的优点,且在治疗过程中毒副作用小、费用低等优势,针对现有西医治疗上述类风湿性关节炎的现状,本发明的目的是在于提供一种治疗类风湿性关节炎的内服药物,以解决类风湿性关节炎患者早日恢复健康的问题。该药物是以常见的中药为原料,具有见效快、疗效显著等特点,并可有效治疗上述类风湿性关节炎。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗类风湿性关节炎的内服药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
桑寄生10~15g、炙甘草2~11g、九节菖蒲4~8g、党参15~25g、熟地黄10~32g、杜仲(盐制)15~26g、白芍10~23g、防风5~10g、当归8~16g、牛膝5~16g、秦艽5~12g、茯苓15~26g、独活5~16g、桂枝2~8g、川芎5~10g、葛根10~16g、薏苡仁15~45g、泽泻6~10g、威灵仙6~9g、赤芍6~12g、防己5~10g、木瓜8~16g、 麻黄2~10g、苍术(炒)3~10g、丝瓜络5~16g。
一种治疗类风湿性关节炎的内服药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
桑寄生11~13g、炙甘草8~10g、九节菖蒲5~7g、党参18~22g、熟地黄15~28g、杜仲(盐制)18~23g、白芍11~20g、防风6~9g、当归10~14g、牛膝8~14g、秦艽8~11g、茯苓18~23g、独活8~14g、桂枝5~7g、川芎6~9g、葛根11~14g、薏苡仁20~41g、泽泻7~9g、威灵仙6~8g、赤芍8~11g、防己6~9g、木瓜10~14g、麻黄6~9g、苍术(炒)6~9g、丝瓜络8~14g。
一种治疗类风湿性关节炎的内服药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
桑寄生12g、炙甘草9g、九节菖蒲6.5g、党参20g、熟地黄25g、杜仲(盐制)20g、白芍17g、防风8g、当归13g、牛膝13g、秦艽10g、茯苓20g、独活13g、桂枝6.5g、川芎8g、葛根13g、薏苡仁35g、泽泻8g、威灵仙7g、赤芍10g、防己8.5g、木瓜13g、 麻黄8g、苍术(炒)8g、丝瓜络13g。
一种治疗类风湿性关节炎的内服药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、将包好的原料中药放入冷开水中浸泡半个小时,然后再将浸泡好的药物和浸泡药物的澄清液一并放入煎药机内,注入过药38mm的冷开水进行第一次煎煮45分钟,滤取药液后,再次注入过药31mm的微温开水进行第二次煎煮40分钟,二次混合浓缩成50%的中药液1080毫升,继而加入常规辅料,加纯化水至含生药量为1g/ml,然后灌封、灭菌制成口服液制剂即可。
一种治疗类风湿性关节炎的内服药物及其制备方法,其特征在于,所述服用方法为:将制备好的口服液制剂分三天服用,早中晚各服一次,给药量120毫升/次,饭前服。服药7~21天,症状逐渐减轻或痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
桑寄生,性味:苦、甘、性平,具有补肝肾、强筋骨、祛风湿、安胎之功效,用于治疗腰膝酸痛、筋骨痿弱、肢体偏枯、风湿痹痛、头错目眩、胎动不安、崩漏下血;
炙甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒,及药物、食物中毒等症;
九节菖蒲,性味:辛、微温,具有开窍、豁痰、祛风、宣湿、健胃、解毒之功效,用于治疗热病神昏谵语、癫痫痰厥、气闭耳聋、多梦健忘、胸痞呕恶、风湿痹痛、疮疥肿毒;
党参,性味:味甘、性平,具有健脾补肺、益气生津之功效,用于治疗脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏等症;
熟地黄,性味:味甘、性温,具有补血滋润、益精填髓之功效,用于治疗血虎萎黄、眩晕心悸、月经不调、崩不止、肝肾阴亏、潮热盗汗、遗精阳痿、不育不孕、腰膝酸软、耳鸣耳聋、头目昏花、须发早白、消渴、便秘、肾虚喘促等症;
杜仲(盐制),性味:甘、微辛、性温,具有补肝肾、强筋骨、安胎之功效,用于治疗腰脊酸疼、阳痿、尿频、小便余沥、风湿痹痛、胎动不安、习惯性流产等症;
白芍,性味:味苦、酸、性凉,具有疏肝理气、柔肝养血、缓中止痛、平肝敛阴之功效,用于治疗肝胃不和所致的胸胁胀痛、脘腹疼痛、月经不调、经行腹痛、崩漏,以及自汗、盗汗、头痛、眩晕等病症;
防风,性味:味辛、甘、性微温,具有祛风解表、胜湿止痛、止痉定搐之功效,用于治疗外感表证、风疹瘙痒、风湿痹痛、破伤风等病症;
当归,性味:性温、味甘辛, 具有补血和血、调经止痛、润燥滑肠之功效,用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤等症;
牛膝,性味:味甘、苦、酸、性平,具有散瘀血、消痈肿的功效,用于腰膝酸痛、下肢痿软、血滞经闭、痛经、产后血瘀腹痛、徵瘕、胞衣不下、热淋、血淋、跌打损伤、痈肿恶疮、咽喉肿痛等病症;
秦艽,性味:辛、苦、微寒,具有袪风湿、舒筋络、清虚热之功效,用于治疗风湿痹痛、筋脉拘挛、骨节酸痛、日晡潮热、小儿疳积发热;
茯苓,性味:甘、淡、平,具有渗湿利水、健脾和胃、宁心安神之功效,用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊等症;
独活,性味:辛、苦、微温,具有祛风除湿、通痹止痛之功效,用于治疗风寒湿痹、腰膝疼痛、少阴伏风头痛;
桂枝,性味:辛、甘、性温,具有散寒解表、温通经脉、通阳化气之功效,用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、癥瘕结块、胸痹、心悸、痰饮、小便不利;
川芎,性味:辛、温,具有活血行气、祛风止痛之功效,用于治疗安抚神经、正头风头痛、症瘕腹痛、胸胁刺痛、跌扑肿痛、头痛、风湿痹痛;
葛根,性味:性凉、味甘、辛,具有解表退热、生津、透疹、升阳止泻之功效,用于治疗外感发热头痛、高血压颈项强痛、口渴、消渴、麻疹不透、热痢、泄泻等症;
薏苡仁,性味:甘淡、凉,具有健脾、补肺、清热、利湿的功能,用于泄泻、湿痹、筋脉拘挛、屈伸不利、水肿、脚气、肺痿、肺痈、肠痈、淋浊、白带等症;
泽泻,性味:甘、寒,具有利小便、清湿热的功效,用于小便不利、水肿胀满、泄泻尿少、痰饮眩晕、热淋涩痛、高血脂;
威灵仙,性味:味辛、咸、微苦、性温,小毒,具有祛风除湿、通络止痛之功效,用于治疗风湿痹痛、肢体麻木、筋脉拘挛、屈伸不利、脚气肿痛、疟疾、骨哽咽喉、并治痰饮积聚等症;
赤芍,性味:苦、微寒,具有清热凉血、散瘀止痛之功效,用于治疗温毒发斑、吐血衄血、目赤肿痛、肝郁胁痛、经闭痛经、症瘕腹痛、跌扑损伤、痈肿疮疡;
防己,性味:苦、寒,具有利水消肿、祛风止痛之功效,用于治疗水肿脚气、小便不利、湿疹疮毒、风湿痹痛、高血压;
木瓜,性味:性温、味酸, 具有消食、驱虫、清热、祛风之功效,用于治疗胃痛、消化不良、肺热干咳、乳汁不通、湿疹、寄生虫病、手脚痉挛疼痛等病症;
麻黄,性味:辛、微苦、性温,具有发汗解表、宣肺平喘、利水消肿之功效,用于治疗风寒表实证、恶寒发热、无汗、头痛身疼、邪壅于肺、肺气不宣、咳嗽气喘、风水肿、小便不利、风湿痹痛、肌肤不仁以及风疹瘙痒、阴疽痰核;
苍术(炒),性味:辛、苦、温,具有燥湿健脾、祛风散寒、明目之功效,用于治疗脘腹胀满、泄泻、水肿、风湿痹痛、风寒感冒、夜盲;
丝瓜络,性味:味苦、性凉,具有通经活络、解毒消肿之功效,用于治疗胸胁疼痛、风湿痹痛、经脉拘挛、乳汁不通、肺势咳嗽、痈前程疮毒。
本发明药物是基于中医治疗类风湿性关节炎的辨病与辨证相结合的原则,从药理作用及作用机制认为:就类风湿性关节炎一症,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述类风湿性关节炎的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
桑寄生12g、炙甘草9g、九节菖蒲6.5g、党参20g、熟地黄25g、杜仲(盐制)20g、白芍17g、防风8g、当归13g、牛膝13g、秦艽10g、茯苓20g、独活13g、桂枝6.5g、川芎8g、葛根13g、薏苡仁35g、泽泻8g、威灵仙7g、赤芍10g、防己8.5g、木瓜13g、 麻黄8g、苍术(炒)8g、丝瓜络13g。
实施例2:
一种治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
桑寄生13g、炙甘草10g、九节菖蒲7g、党参22g、熟地黄28g、杜仲(盐制)23g、白芍20g、防风9g、当归14g、牛膝14g、秦艽11g、茯苓23g、独活14g、桂枝7g、川芎9g、葛根14g、薏苡仁41g、泽泻9g、威灵仙8g、赤芍11g、防己9g、木瓜14g、 麻黄9g、苍术(炒)9g、丝瓜络14g。
实施例3:
一种治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
桑寄生15g、炙甘草11g、九节菖蒲8g、党参25g、熟地黄32g、杜仲(盐制)26g、白芍23g、防风10g、当归16g、牛膝16g、秦艽12g、茯苓26g、独活16g、桂枝8g、川芎10g、葛根16g、薏苡仁45g、泽泻10g、威灵仙9g、赤芍12g、防己10g、木瓜16g、 麻黄10g、苍术(炒)10g、丝瓜络16g。
典型病例:
经临床诊断治疗类风湿性关节炎患者共133例,年龄为53岁以上的90例,只有43例为53岁以下。133例患者中痊愈的112例,显效的21例,总有效率达100%。经治疗后,症状逐渐减轻或痊愈。

Claims (3)

1.一种治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
桑寄生10~15g、炙甘草2~11g、九节菖蒲4~8g、党参15~25g、熟地黄10~32g、杜仲(盐制)15~26g、白芍10~23g、防风5~10g、当归8~16g、牛膝5~16g、秦艽5~12g、茯苓15~26g、独活5~16g、桂枝2~8g、川芎5~10g、葛根10~16g、薏苡仁15~45g、泽泻6~10g、威灵仙6~9g、赤芍6~12g、防己5~10g、木瓜8~16g、 麻黄2~10g、苍术(炒)3~10g、丝瓜络5~16g。
2.根据权利要求1所述的治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
桑寄生11~13g、炙甘草8~10g、九节菖蒲5~7g、党参18~22g、熟地黄15~28g、杜仲(盐制)18~23g、白芍11~20g、防风6~9g、当归10~14g、牛膝8~14g、秦艽8~11g、茯苓18~23g、独活8~14g、桂枝5~7g、川芎6~9g、葛根11~14g、薏苡仁20~41g、泽泻7~9g、威灵仙6~8g、赤芍8~11g、防己6~9g、木瓜10~14g、麻黄6~9g、苍术(炒)6~9g、丝瓜络8~14g。
3.根据权利要求1至2所述的治疗类风湿性关节炎的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
桑寄生12g、炙甘草9g、九节菖蒲6.5g、党参20g、熟地黄25g、杜仲(盐制)20g、白芍17g、防风8g、当归13g、牛膝13g、秦艽10g、茯苓20g、独活13g、桂枝6.5g、川芎8g、葛根13g、薏苡仁35g、泽泻8g、威灵仙7g、赤芍10g、防己8.5g、木瓜13g、 麻黄8g、苍术(炒)8g、丝瓜络13g。
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CN105412339A (zh) * 2015-12-02 2016-03-23 天津太平洋制药有限公司 一种治疗类风湿性关节炎的药物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582812A (zh) * 2017-08-11 2018-01-16 成都市飞龙水处理技术研究所青白江第分所 一种治疗类风湿性关节炎的内服药物及其制备方法

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