CN106177596A - One is dispelled nevus pharmaceutical composition and its preparation method and application - Google Patents
One is dispelled nevus pharmaceutical composition and its preparation method and application Download PDFInfo
- Publication number
- CN106177596A CN106177596A CN201610794414.5A CN201610794414A CN106177596A CN 106177596 A CN106177596 A CN 106177596A CN 201610794414 A CN201610794414 A CN 201610794414A CN 106177596 A CN106177596 A CN 106177596A
- Authority
- CN
- China
- Prior art keywords
- nevus
- parts
- pharmaceutical composition
- dispelling
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses one to dispel nevus pharmaceutical composition, mainly by made by the raw material of following parts by weight: Herba Violae 40 58 parts, Radix Paeoniae Rubra 35 48 parts, Rhizoma Phragmitis 20 28 parts, Cornu Bubali 10 15 parts, glycerol 58 parts, butanediol 8 15 parts, glycyrrhizic acid dipotassium 25 parts, 14 parts of copper sulfate, citric acid 23 parts；The invention also discloses the preparation method and application of a kind of nevus pharmaceutical composition of dispelling.The nevus pharmaceutical composition drug effect of dispelling of the present invention is gentle, have no side effect, can effectively dispel the nevus on skin, and due to containing Rhizoma Phragmitis and Cornu Bubali in this pharmaceutical composition, with can repair impaired skin after other component combine rapidly, it is allowed to recover the original gloss of skin and to smooth, convalescent period after nevus that makes to dispel is greatly shortened, relapse rate is low, do not injure corium little to skin harm simultaneously, the preparation method of the present invention is simple and convenient simultaneously, raw material availability is high, can be greatly improved bioavailability.
Description
Technical field
The present invention relates to pharmaceutical composition, be specifically related to one and dispel nevus pharmaceutical composition and its preparation method and application.
Background technology
Nevus have broad sense and narrow sense point, broad sense includes various congenital, posteriority melanocytic nevus, sebaceous nevus etc..Doctor
" nevus " on is narrow sense, also known as nevus cell nevus, nevus cell nevus, melanocytic nevus or common acquired melanocytic naevi, no
Including congenital amaurosis chromatophore nevus.Nevus is the modal benign skin tumours of the mankind, is epidermis, intradermal melanocytosis
The cutaneous manifestations caused.Different according to nevus cell position in skin, junctional nevus, compound nevus and intradermal nevus can be classified as.
Flat skin lesion prompts for junctional nevus, and slightly higher skin lesion mostly is compound nevus, and papillary tumor sample skin lesion and nearly all hemispherical and band
Tippi damages as intradermal nevus.
The most common several nevus methods of dispelling have: 1. chemicals, have on the market and burn with strong acid or highly basic chemical agent,
Hospital is then with trichloroacetic acid point nevus, better than shallower combination nevus effectiveness comparison for just appearance, often can be because burning excessively
Cause the scar of depression, or cause the scar of projection because of cicatrix body constitution；2. electricity burns, for the combination nevus of shallow-layer and deeper and convex
The complex nevus risen is effective.But operate wayward, easily produce cicatrix；3. freezing, with liquid nitrogen freezing nevus.To prominent and flat
Nevus can effectively remove, owing to severity control is difficult to, often result in injury, therefore now department of dermatologry is not used in the process of nevus more；4.
Excision, the removal that can put things right once and for all, if there being possible nevus of cancerating, pathologic diagnosis can also be carried out after excision, cutting
Except the one that art is operation, it is therefore necessary to upper anaesthetic and stitching, wound is less susceptible to look after.
In prior art, either which kind of is dispelled nevus method, and the injury to skin is the biggest, easily injures corium, simultaneously this
Nevus method convalescent period of dispelling is longer, is difficult to dispel clean simultaneously, easily recurs.
Summary of the invention
Goal of the invention: for problems of the prior art, the present invention provides one to dispel nevus pharmaceutical composition, this medicine
Compositions can eliminating naevus effectively, do not injure that corium is little to skin harm simultaneously, recover soon, do not recur.
It is a further object to provide the preparation method and application of this nevus pharmaceutical composition of dispelling.
Technical scheme: to achieve these goals, one as described in the present invention is dispelled nevus pharmaceutical composition, mainly by following
Made by the raw material of parts by weight: Herba Violae 40-58 part, Radix Paeoniae Rubra 35-48 part, Rhizoma Phragmitis 20-28 part, Cornu Bubali 10-15 part, sweet
Oil 5-8 part, butanediol 8-15 part, glycyrrhizic acid dipotassium 2-5 part, copper sulfate 1-4 part, citric acid 2-3 part.
Described nevus pharmaceutical composition of dispelling, mainly by made by the raw material of following parts by weight: Herba Violae 45-50 part, red
Chinese herbaceous peony 40-45 part, Rhizoma Phragmitis 25-28 part, Cornu Bubali 12-14 part, glycerol 6-8 part, butanediol 10-13 part, glycyrrhizic acid dipotassium 2-4 part,
Copper sulfate 2-4 part, citric acid 2-3 part.
The preparation method of above-mentioned nevus pharmaceutical composition of dispelling, comprises the steps:
(1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 50-60 mesh sieve, add butanediol
It is stripped, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 80-100 mesh sieve, and added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 2-4 times, add
Filter after heat, obtain mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Further, the temperature of step (1) described extracting is 40-60 DEG C, and the time is 2-3h.
Further, the temperature carrying out reacting in step (3) described reactor is 50-56 DEG C, and rotating speed is 150-200rpm,
Time 4-6h.
Above-mentioned nevus pharmaceutical composition of dispelling is utilized to prepare naevus removing ointment or the application in nevus liquid medicine of dispelling.
Beneficial effect: compared by prior art, the nevus pharmaceutical composition drug effect of dispelling of the present invention is gentle, have no side effect, permissible
Effectively dispel the nevus on skin, and due to after containing Rhizoma Phragmitis and Cornu Bubali, with other component combine in this pharmaceutical composition
Impaired skin can be repaired rapidly, allow it recover the original gloss of skin and to smooth so that the convalescent period after nevus of dispelling is significantly
Shortening, relapse rate is low, does not injure corium little to skin harm simultaneously, and the preparation method of the present invention is simple and convenient simultaneously, raw material profit
High by rate, bioavailability can be greatly improved.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1
Prescription:
Herba Violae 40 parts, Radix Paeoniae Rubra 35 parts, Rhizoma Phragmitis 20 parts, Cornu Bubali 15 parts, glycerol 8 parts, butanediol 8 parts, glycyrrhizic acid two
2 parts of potassium, 4 parts of copper sulfate, citric acid 2 parts.
Preparation method:
(1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 50 mesh sieves, add butanediol and carry out
Extracting, extraction temperature is 40 DEG C, and the time is 3h, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 80 mesh sieves, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 2 times, mistake after heating
Filter, obtains mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, temperature is 50-DEG C, and rotating speed is 150rpm, time 6h, and reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Embodiment 2
Prescription:
Herba Violae 58 parts, Radix Paeoniae Rubra 48 parts, Rhizoma Phragmitis 28 parts, Cornu Bubali 10 parts, glycerol 5 parts, butanediol 15 parts, glycyrrhizic acid two
5 parts of potassium, 1 part of copper sulfate, citric acid 3 parts.
Preparation method:
(1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 60 mesh sieves, add butanediol and carry out
Extracting, extraction temperature is 60 DEG C, and the time is 2h, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 100 mesh sieves, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 4 times, mistake after heating
Filter, obtains mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, temperature is 56 DEG C, and rotating speed is 200rpm, time 4h, and reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Embodiment 3
Prescription:
Herba Violae 49 parts, Radix Paeoniae Rubra 42 parts, Rhizoma Phragmitis 24 parts, Cornu Bubali 13 parts, glycerol 6.5 parts, butanediol 12 parts, glycyrrhizic acid
Dipotassium 3.5 parts, 2.5 parts of copper sulfate, citric acid 2.5 parts.
Preparation method:
(1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 55 mesh sieves, add butanediol and carry out
Extracting, extraction temperature is 50 DEG C, and the time is 2.5h, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 90 mesh sieves, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 3 times, mistake after heating
Filter, obtains mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, temperature is 53 DEG C, and rotating speed is 175rpm, time 5h, and reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Embodiment 4
Prescription:
Herba Violae 45 parts, Radix Paeoniae Rubra 40 parts, Rhizoma Phragmitis 25 parts, Cornu Bubali 12 parts, glycerol 6 parts, butanediol 10 parts, glycyrrhizic acid two
2 parts of potassium, 2 parts of copper sulfate, citric acid 2 parts.
Preparation method:
1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 55 mesh sieves, add butanediol and carry out
Extracting, extraction temperature is 50 DEG C, and the time is 2.5h, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 90 mesh sieves, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 3 times, mistake after heating
Filter, obtains mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, temperature is 53 DEG C, and rotating speed is 175rpm, time 5h, and reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Embodiment 5
Prescription:
Herba Violae 50 parts, Radix Paeoniae Rubra 45 parts, Rhizoma Phragmitis 28 parts, Cornu Bubali 14, glycerol 8 parts, butanediol 13 parts, glycyrrhizic acid dipotassium
4 parts, 4 parts of copper sulfate, citric acid 3 parts.
Preparation method:
1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 55 mesh sieves, add butanediol and carry out
Extracting, extraction temperature is 50 DEG C, and the time is 2.5h, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 90 mesh sieves, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 3 times, mistake after heating
Filter, obtains mixed liquid B；
(3), after mixed liquor A and mixed liquid B being mixed, glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid are added, after stirring
Joining in reactor and react, temperature is 53 DEG C, and rotating speed is 175rpm, time 5h, and reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Embodiment 6
Utilize the nevus pharmaceutical composition of dispelling that embodiment 3 obtains, add the distilled water of 5-8 times of weight, and various adjuvant is all
Intellectual circle, liquid Paraffin, decoct into paste always, carries out subpackage, makes the naevus removing ointment can being coated directly on application on human skin nevus.
Embodiment 7
The nevus pharmaceutical composition of dispelling utilizing embodiment 4 to obtain is clayed into power and is added the distilled water of 1-2 times of weight, adds
The dehydrated alcohol of 0.5-1 times of volume, filters after impregnating 24-30 hour, carry out subpackage, make and can be coated directly under air-proof condition
Nevus liquid medicine of dispelling on application on human skin nevus.
Test example 1
Choosing 120 and have nevus patient, be divided into 6 groups, often organize 20 people, everyone chooses 5 close nevuss of size with it；It is divided into
Matched group 1, matched group 2, matched group 3, matched group 4, test group 1, test group 2.The use of 6 groups is dispelled nevus liquid medicine or naevus removing ointment
After nevus effect of dispelling, convalescent period, relapse rate, skin injury situation detects, and the results are shown in Table 1.
Matched group 1 uses commercially available nevus liquid medicine of dispelling；
The prescription that naevus removing ointment is embodiment 3 that matched group 2 uses is removed Rhizoma Phragmitis and Cornu Bubali and uses the preparation of embodiment 3
Method gained is dispelled nevus pharmaceutical composition, then by obtained by embodiment 6 method；
The prescription that naevus removing ointment is embodiment 3 that matched group 3 uses is removed Rhizoma Phragmitis and uses the preparation method gained of embodiment 3
Dispel nevus pharmaceutical composition, then by obtained by embodiment 6 method；
The prescription that naevus removing ointment is embodiment 3 that matched group 4 uses is removed Cornu Bubali and uses the preparation method institute of embodiment 3
Must dispel nevus pharmaceutical composition, then by obtained by embodiment 6 method；
Test group 1 uses the embodiment of the present invention 6 to prepare naevus removing ointment；
Test example 2 uses the embodiment of the present invention 7 to prepare nevus liquid medicine of dispelling.
Table 1 use naevus removing ointment or liquid medicine after nevus effect of dispelling, convalescent period, relapse rate, skin injury situation
As shown in table 1, gained of the present invention is dispelled the naevus removing ointment made by nevus pharmaceutical composition or dispel nevus liquid medicine and matched group
Compare, can effective eliminating naevus, the rate of dispelling reaches more than 98%, recovers fast 5-10 days cicatrixes simultaneously and is just wholly absent and without red
Speckle, the same with the skin of surrounding, relapse rate is low less than 10% simultaneously, the skin also not damaged to nevus surrounding.
Claims (6)
1. a nevus pharmaceutical composition of dispelling, it is characterised in that main by made by the raw material of following parts by weight: Herba Violae
40-58 part, Radix Paeoniae Rubra 35-48 part, Rhizoma Phragmitis 20-28 part, Cornu Bubali 10-15 part, glycerol 5-8 part, butanediol 8-15 part, glycyrrhizic acid two
Potassium 2-5 part, copper sulfate 1-4 part, citric acid 2-3 part.
Nevus pharmaceutical composition of dispelling the most according to claim 1, it is characterised in that main by the raw material institute of following parts by weight
Make: Herba Violae 45-50 part, Radix Paeoniae Rubra 40-45 part, Rhizoma Phragmitis 25-28 part, Cornu Bubali 12-14 part, glycerol 6-8 part, butanediol
10-13 part, glycyrrhizic acid dipotassium 2-4 part, copper sulfate 2-4 part, citric acid 2-3 part.
3. the preparation method of the nevus pharmaceutical composition of dispelling described in claim 1, it is characterised in that comprise the steps:
(1) above-mentioned raw materials is weighed by recipe ratio, Herba Violae and Radix Paeoniae Rubra were pulverized 50-60 mesh sieve, add butanediol and carry out
Extracting, obtains extracting solution A；
(2) Rhizoma Phragmitis and Cornu Bubali were pulverized 80-100 mesh sieve, added Rhizoma Phragmitis and the water of Cornu Bubali gross weight 2-4 times, after heating
Filter, obtain mixed liquid B；
(3) after mixed liquor A and mixed liquid B being mixed, add glycerol, glycyrrhizic acid dipotassium, copper sulfate, citric acid, add after stirring
Reacting in reactor, reaction end obtains material；
(4) step (3) reaction end is obtained material, sucking filtration, washing, i.e. obtain nevus pharmaceutical composition of dispelling after drying.
Preparation method the most according to claim 3, it is characterised in that the temperature of step (1) described extracting is 40-60 DEG C,
Time is 2-3h.
Preparation method the most according to claim 3, it is characterised in that carry out the temperature reacted in step (3) described reactor
Degree is for 50-56 DEG C, and rotating speed is 150-200rpm, time 4-6h.
6. the nevus pharmaceutical composition of dispelling described in claim 1 is preparing naevus removing ointment or the application in nevus liquid medicine of dispelling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610794414.5A CN106177596A (en) | 2016-08-31 | 2016-08-31 | One is dispelled nevus pharmaceutical composition and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610794414.5A CN106177596A (en) | 2016-08-31 | 2016-08-31 | One is dispelled nevus pharmaceutical composition and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106177596A true CN106177596A (en) | 2016-12-07 |
Family
ID=58086307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610794414.5A Withdrawn CN106177596A (en) | 2016-08-31 | 2016-08-31 | One is dispelled nevus pharmaceutical composition and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106177596A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927227A (en) * | 2006-09-05 | 2007-03-14 | 吴云峰 | External application plaster for removing nevus |
| CN103764107A (en) * | 2011-06-08 | 2014-04-30 | 玫琳凯有限公司 | Sunscreen formulations |
| CN104306531A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine used for treating vascular nevus |
| CN104435455A (en) * | 2014-12-23 | 2015-03-25 | 青岛海芬海洋生物科技有限公司 | Point mole removing agent |
| CN105687230A (en) * | 2016-03-17 | 2016-06-22 | 牛斌 | Nevus-removing cream and preparation method thereof |
-
2016
- 2016-08-31 CN CN201610794414.5A patent/CN106177596A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927227A (en) * | 2006-09-05 | 2007-03-14 | 吴云峰 | External application plaster for removing nevus |
| CN103764107A (en) * | 2011-06-08 | 2014-04-30 | 玫琳凯有限公司 | Sunscreen formulations |
| CN104306531A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine used for treating vascular nevus |
| CN104435455A (en) * | 2014-12-23 | 2015-03-25 | 青岛海芬海洋生物科技有限公司 | Point mole removing agent |
| CN105687230A (en) * | 2016-03-17 | 2016-06-22 | 牛斌 | Nevus-removing cream and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 宋业强等: "《实用中医美容金方》", 30 April 2008, 中医古籍出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103655818B (en) | A kind of ointment treating scald | |
| CN110772550B (en) | Method for preparing ellagic acid from scalded myrobalan meat and application | |
| CN106177596A (en) | One is dispelled nevus pharmaceutical composition and its preparation method and application | |
| CN107496267A (en) | A kind of acne-eliminating cosmetic and preparation method thereof | |
| CN108553376A (en) | A kind of pox-eliminating whitening cream and preparation method thereof | |
| CN106236951A (en) | A kind of burn and scald for the treatment of injures the Chinese medicine composition of scar after the operation | |
| CN109432065A (en) | A kind of stealthy net acne patch of konjaku glucomannan | |
| CN104146180A (en) | Preparation method of feed capable of preventing pig influenza | |
| CN108703905A (en) | A kind of skin is releived liquid and preparation method thereof | |
| CN103599248B (en) | A kind of ointment for the treatment of scald | |
| CN106215020A (en) | A kind of pharmaceutical composition of whitening and speckle dispelling and its preparation method and application | |
| CN103877196A (en) | Ointment for treating scald | |
| JP3967238B2 (en) | Topical skin preparation | |
| CN102940881B (en) | Ointment for treating skin scalds | |
| CN106177178A (en) | The donkey-hide gelatin sea cucumber Qi Dihuang soft extract of a kind of fatigue alleviating and preparation method | |
| CN101926894A (en) | Active antioxidant and preparation process thereof | |
| CN110585278A (en) | Health-care vinasse applying mud and preparation method thereof | |
| CN110522685A (en) | A kind of more effect facial masks and preparation method thereof | |
| CN110403980A (en) | A kind of burn and scald composition and preparation method thereof | |
| CN106427179A (en) | Preparation method of wheat germ protein hemostatic bandage | |
| CN112168949B (en) | Health product for adolescent women | |
| CN107595712A (en) | A kind of blemish clearing gel and preparation method thereof | |
| CN107837315A (en) | A kind of Chinese medicine composition for treating the fungal infection of the hand and preparation method thereof | |
| CN109908275A (en) | A kind of emergency department's nursing efficient quick-acting haemostatic powder patch and preparation method thereof | |
| CN111840407A (en) | Material for promoting wound healing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161207 |