CN106177125A - A kind of method preparing the pharmaceutical composition promoting wound healing - Google Patents
A kind of method preparing the pharmaceutical composition promoting wound healing Download PDFInfo
- Publication number
- CN106177125A CN106177125A CN201610592685.2A CN201610592685A CN106177125A CN 106177125 A CN106177125 A CN 106177125A CN 201610592685 A CN201610592685 A CN 201610592685A CN 106177125 A CN106177125 A CN 106177125A
- Authority
- CN
- China
- Prior art keywords
- extract
- pharmaceutical composition
- chloroform
- wound healing
- wound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to pharmaceutical technology field, a kind of method particularly to pharmaceutical composition prepared and promote wound healing, active component in pharmaceutical composition prepared by the present invention is made up of as sole active agent the chloroform extract extract of Radix Pedicularis Henryi, pharmaceutical composition oral administration, can be reduced inflammation reaction, promotes new vessels and fibroblastic hypertrophy.
Description
The application is that the application for a patent for invention that applicant Cui Yinfang proposes is (invention entitled: a kind of to promote wound healing
Pharmaceutical composition and preparation method thereof, Application No.: 2014104203058, filing date: on August 25th, 2014) division Shen
Please.
Technical field
The invention belongs to technical field of extraction of Chinese traditional medicine, be specifically related to a kind of pharmaceutical composition preparing promotion wound healing
Method.
Background technology
Skin is the organ that human body is maximum, and it is wrapped in the whole surface of human body, and with digestion, breathing, urinary system, reproductive system
The mucous epithelium of collar extension is connected, thus constitutes the optimal coat of human body, and protection internal organs are invaded with the extraneous various factors of prevention
Attack.But owing to it is in the outermost layer of human body, so daily life can be baited, extruded, rubbed, be fallen that the situation such as to touch be very difficult
Avoid.Would generally occur hurting, scratch, blood stasis, injure by a crashing object, squeeze wound, scratch, laceration, stab, the traumatic condition such as mosquito is bitten, burn and scald,
Also have the wound such as decubital ulcer, surgical wound within the hospital, after these traumatic conditions occur, it is necessary to process in time, otherwise can be thin due to cause of disease
The intrusion generation pyogenic infection of bacterium, will also result in local and occurs red, swollen, hot, bitterly and dysfunction, time serious due to antibacterial and
Toxin enters blood circulation can cause the diseases such as toxemia, septicemia and tetanus, can cause extremely serious consequence.
The processing method of the traumatic wounds that operation causes is by modern Western medicine surgery, and to wound sterilizing, sterilization, application is anti-
Raw element prevents from infecting, by the method for hospital gauze wrapping after sewing up a wound.Stitching has Guan Bi wound, promotes hemostasis and tissue more
Cooperation use, is the most basic technology of modern surgery, and therefore manual suture is current most widely used method.It addition, outside the modern times
Section's not medication on wound, the healing of wound is that the tissue by body self is repaired.General 2-3 days after surgery, Huan Zhegeng
Change a dressing, it is therefore an objective to for observing and clean wound.As can be seen here, doctor trained in Western medicine fully relies on patient for the healing of postoperative wound
The tissue repairing ability of itself, wound healing is slow, and adds the risk that patient infects.
Summary of the invention
In view of the deficiencies in the prior art, it is an object of the invention to by Chinese herbal medicine is studied, thus provide a kind of
Preparation promotes the method for the pharmaceutical composition of wound healing, pharmaceutical composition oral administration prepared by the method, can alleviate inflammation
Disease is reacted, and promotes new vessels and fibroblastic hypertrophy.
In order to realize first purpose of the present invention, inventor, by lot of experiments research persistent exploration, finally obtains
Following technical scheme:
A kind of combination of oral medication promoting wound healing, wherein, the described active component in pharmaceutical composition comprises phoenix
The chloroform extract extract of tail ginseng.
Preferably, the combination of oral medication promoting wound healing as above, in wherein said pharmaceutical composition
Active component be made up of as sole active agent the chloroform extract extract of Radix Pedicularis Henryi.
Second object of the present invention is to provide the preparation of a kind of pharmaceutical composition according to above-mentioned promotion wound healing
Method, wherein the method comprises the steps: that by Radix Pedicularis Henryi raw material concentration be 72%-80%(v/v) alcohol reflux 1-3h,
Filtering, filtrate reduced in volume, to dry, obtain crude extract, becomes suspension with water dissolution, adds chloroform extraction, obtains chloroform extract,
After chloroform extract recycling design, be condensed into thick paste, be dried, obtain the chloroform extract extract of Radix Pedicularis Henryi, then with pharmaceutically can use
Auxiliary materials and mixing be prepared as oral solid formulation.
Preferably, the preparation method of the pharmaceutical composition of wound healing is promoted as mentioned above, wherein described in step (1)
Alcohol heating reflux extraction step repeats 2-3 time, and the addition of each ethanol is 6-10 times (v/w) of Radix Pedicularis Henryi raw material.
Preferably, the preparation method of the pharmaceutical composition of wound healing, wherein said oral administration solid are promoted as mentioned above
Preparation includes tablet, capsule and granule.
Mice full thickness skin excision wound model is done by the present inventor by the chloroform extract extract of research Radix Pedicularis Henryi
Trial test result of study shows, the chloroform extract group wound when 7d heals substantially, and epithelium is complete, has normal horny layer shape
Becoming, blood vessel is few, and under epidermis, a large amount of collagens are formed, basic and epidermis Parallel Growth；Have no skin appendages.And blank group exists
Just observing during 9d that granulation tissue is filled substantially with wound, epidermis starts hypertrophy and covers the overwhelming majority of wound surface, but wound
Heal the most comprehensively.The chloroform extract extract of Radix Pedicularis Henryi prepared by this explanation present invention can significantly accelerate wound healing, in 7 days
Can substantially heal.Therefore, third object of the present invention is to provide a kind of pharmaceutical applications, the chloroform of the most above-mentioned Radix Pedicularis Henryi
Extractive part purposes in preparation promotes the medicine of wound healing.
Compared with prior art, the pharmaceutical composition of the present invention has the effect preferably reduced inflammation, and can be obviously promoted new
Angiogenic and fibroblastic hypertrophy, have significant facilitation to skin wound healing.
Detailed description of the invention
The following is concrete preparation example and the animal experiment example of Radix Pedicularis Henryi extract involved in the present invention, the technology to the present invention
Scheme is done and is described further, but protection scope of the present invention is not limited to this embodiment.It should be noted that each embodiment
In Radix Pedicularis Henryi select Scrophulariaceae lousewort plant south of the River Radix seu Herba Pedicularis Pedicularis henryi Maxim. dry root.
The preparation of the chloroform extract extract of embodiment 1 Radix Pedicularis Henryi
The Radix Pedicularis Henryi dry product 782g cleaning up and being dried, pulverizes with Chinese medicine grinder, is placed in the extraction with round-bottomed flask and fills
In putting, it is 78%(v/v by concentration) ethanol 6L reflux, extract, 2h, filters, obtains alcohol extract, be repeated 2 times, merge alcohol extract, decompression
It is concentrated to dryness, obtains crude extract, be dissolved into suspension with 2.5L pure water, extract 2 times with 2.5L chloroform, obtain chloroform extract,
Continue concentrating under reduced pressure after reclaiming chloroform and become thick paste, lyophilization, be ground into fine powder, cross 100 mesh sieves, obtain the chloroform portion of Radix Pedicularis Henryi
Position extract.
The preparation of the chloroform extract extract of embodiment 2 Radix Pedicularis Henryi
The Radix Pedicularis Henryi dry product 1.5kg cleaning up and being dried, pulverizes with Chinese medicine grinder, is placed in the extraction with round-bottomed flask and fills
In putting, it is 72%(v/v by concentration) ethanol 12L reflux, extract, 2h, filters, obtains alcohol extract, be repeated 2 times, merge alcohol extract, subtract
Pressure is concentrated to dryness, and obtains crude extract, is dissolved into suspension with 4L pure water, extracts 2 times with 4L chloroform, obtains chloroform extract, returns
Continue concentrating under reduced pressure after receiving chloroform and become thick paste, lyophilization, be ground into fine powder, cross 100 mesh sieves, obtain the chloroform extract of Radix Pedicularis Henryi
Extract.
The preparation of comparative example 1 Radix Pedicularis Henryi water extract
The Radix Pedicularis Henryi dry product 700g cleaning up and being dried, pulverizes with Chinese medicine grinder, is placed in the extraction with round-bottomed flask and fills
In putting, by 7L pure water heating and refluxing extraction 2h, filter, obtain Aqueous extracts, be repeated 2 times, merge Aqueous extracts, be evaporated to do,
Obtain water extract, be ground into fine powder, cross 100 mesh sieves, obtain Radix Pedicularis Henryi water extract.
The impact test that wounds in mice is healed by embodiment 3 Radix Pedicularis Henryi extract
Take 64 male and healthy kunming mices, 22-26g, be randomly divided into 3 groups, often group 24, i.e. blank group, water extract group,
Chloroform extract group.Set up mice full thickness skin excision wound model as follows: after sucking ether gas anesthesia, back is cut
Hair, does a skin holostrome otch at center back after routine disinfection, and wound surface naturally stops blooding, do not wraps up, not dispenser.After incised wound, often
Mice sub-cage rearing, gives sterilize feedstuff and distilled water, keeps wound to be dried, prevents wound infection.Meanwhile, every day is to mice
Carrying out gavage by being administered volume 0.1mL/10g, respectively on the basis of the weight of mice, water extract group gives comparative example 1 and prepares
Radix Pedicularis Henryi water extract dry powder 0.62g/kg, chloroform extract group gives the chloroform extract extract of Radix Pedicularis Henryi of embodiment 1 preparation
Dry powder 0.62g/kg, blank group gives isopyknic solvent.0,5,9,12d time point, edge of wound is depicted in
On bright pan paper, then use Qing Hua Ziguang's A900 scanner scanning and with American I mage-Pro 8. PlusVersion6.0
(IPP) image analysis software measured area, observes skin healing situation respectively, and takes 6 execution from often group at random and take it
Wound tissue's routine paraffin wax embeds, section, and HE dyes, its histological change of light Microscopic observation.
Wound the 0th, 4,7,9d time the statistical result of wound area be shown in Table 1.Result of the test according to table 1 can be seen
Going out, after modeling cause on same day wound, each group wound surface does not heals and is not significantly different between area；Wound the 4th, 7,9d time, chloroform
Position group compare with blank group or water extract group have pole significant difference (P＜ 0.01), this explanation is the present invention prepare
The chloroform extract extract of Radix Pedicularis Henryi can significantly accelerate wound healing, can substantially heal in 7 days.It should be noted that
After being administered 4d, the wound area of water extract group more than blank group, this imply that Radix Pedicularis Henryi water extract pressed down in the later stage always
Make the healing of wound.
After table 1 respectively organizes mice modeling, (mm is compared in wound area change2)
Compare with blank group,* P＜ 0.05,** P＜ 0.01；
Compare with water extract group,$ P＜ 0.05,$$ P＜ 0.01.
It addition, HE stained is it was found that the chloroform extract group wound when 7d heals substantially, epithelium is complete, has
Normal horny layer is formed, and blood vessel is few, and under epidermis, a large amount of collagens are formed, basic and epidermis Parallel Growth；Have no skin appendages.And
Blank group just observes that when 9d granulation tissue is filled substantially with wound, and epidermis starts hypertrophy and covers the biggest of wound surface
Part, but wound heals the most comprehensively.
Claims (2)
1. the method preparing the pharmaceutical composition promoting wound healing, it is characterised in that: described promotion wound healing
Active component in pharmaceutical composition is made up of as sole active agent the chloroform extract extract of Radix Pedicularis Henryi；
The preparation method of described pharmaceutical composition is as follows: be 72%-80%v/v alcohol reflux 1-by Radix Pedicularis Henryi raw material concentration
3h, filters, and filtrate reduced in volume, to dry, obtain crude extract, becomes suspension with water dissolution, adds chloroform extraction, obtains chloroform extraction
Liquid, is condensed into thick paste after chloroform extract recycling design, is dried, obtains the chloroform extract extract of Radix Pedicularis Henryi, then with pharmaceutically
Available auxiliary materials and mixing is prepared as oral solid formulation；Described alcohol heating reflux extraction step repeats 2-3 time, each ethanol
The 6-10 times of v/w that addition is Radix Pedicularis Henryi raw material.
The method preparing the pharmaceutical composition promoting wound healing the most according to claim 1, it is characterised in that: described medicine
Compositions is tablet, capsule or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610592685.2A CN106177125A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410420305.8A CN104189223B (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing and preparation method thereof |
| CN201610592685.2A CN106177125A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410420305.8A Division CN104189223B (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106177125A true CN106177125A (en) | 2016-12-07 |
Family
ID=52074695
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610592905.1A Withdrawn CN106177126A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
| CN201410420305.8A Expired - Fee Related CN104189223B (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing and preparation method thereof |
| CN201610593165.3A Withdrawn CN106177127A (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing |
| CN201610592685.2A Withdrawn CN106177125A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
| CN201610593164.9A Withdrawn CN106109679A (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing |
| CN201610592507.XA Withdrawn CN106109677A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
| CN201610592882.4A Withdrawn CN106109678A (en) | 2014-08-25 | 2014-08-25 | The chloroform extract extract of Radix Pedicularis Henryi purposes in preparation promotes the medicine of wound healing |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610592905.1A Withdrawn CN106177126A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
| CN201410420305.8A Expired - Fee Related CN104189223B (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing and preparation method thereof |
| CN201610593165.3A Withdrawn CN106177127A (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610593164.9A Withdrawn CN106109679A (en) | 2014-08-25 | 2014-08-25 | A kind of pharmaceutical composition promoting wound healing |
| CN201610592507.XA Withdrawn CN106109677A (en) | 2014-08-25 | 2014-08-25 | A kind of method preparing the pharmaceutical composition promoting wound healing |
| CN201610592882.4A Withdrawn CN106109678A (en) | 2014-08-25 | 2014-08-25 | The chloroform extract extract of Radix Pedicularis Henryi purposes in preparation promotes the medicine of wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (7) | CN106177126A (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009046391A (en) * | 2005-07-06 | 2009-03-05 | Takehito Kono | Pharmaceutical preparation for improving and treating cachexia and food preparation having cachexia-improving action |
| CN101168551B (en) * | 2007-11-16 | 2010-12-15 | 河北大学 | lousewort lignans compounds, preparation method and application thereof |
| CN102786505B (en) * | 2012-09-05 | 2014-12-17 | 中国科学院西北高原生物研究所 | Preparation method for separating three flavone monomeric compounds from flos pedicularis |
-
2014
- 2014-08-25 CN CN201610592905.1A patent/CN106177126A/en not_active Withdrawn
- 2014-08-25 CN CN201410420305.8A patent/CN104189223B/en not_active Expired - Fee Related
- 2014-08-25 CN CN201610593165.3A patent/CN106177127A/en not_active Withdrawn
- 2014-08-25 CN CN201610592685.2A patent/CN106177125A/en not_active Withdrawn
- 2014-08-25 CN CN201610593164.9A patent/CN106109679A/en not_active Withdrawn
- 2014-08-25 CN CN201610592507.XA patent/CN106109677A/en not_active Withdrawn
- 2014-08-25 CN CN201610592882.4A patent/CN106109678A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN104189223A (en) | 2014-12-10 |
| CN104189223B (en) | 2016-09-07 |
| CN106109678A (en) | 2016-11-16 |
| CN106109679A (en) | 2016-11-16 |
| CN106109677A (en) | 2016-11-16 |
| CN106177127A (en) | 2016-12-07 |
| CN106177126A (en) | 2016-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101648002B (en) | Medicinal composition for treating skin injury and ulcer and application thereof | |
| CN105363064B (en) | A kind of compound aloe barbadensis Miller polysaccharide gel antiseptic dressing for treatment burn | |
| CN104940905A (en) | Medicine composition for promoting wound healing after operation and preparation method thereof | |
| CN107137498B (en) | Traditional Chinese medicine gel for treating haemorrhoids and preparation method thereof | |
| CN102302678A (en) | Skin membrane repair drug | |
| CN105581964A (en) | Product for rejuvenating and beautifying and preparation method thereof | |
| TW200942270A (en) | Chinese medicine composition for treatment of wounds or bedsore, and method for producing preparation thereof | |
| CN108324816A (en) | A kind of anaesthetic and preparation method thereof for treating rheumatic arthritis | |
| CN105031622A (en) | Pharmaceutical composition capable of promoting wound healing, and preparation method thereof | |
| CN102716281A (en) | Care solution for cleaning wounds after operation | |
| CN109731040A (en) | A kind of wound remediation composition, preparation method and applications | |
| CN101491609A (en) | Burn and scald treatment preparation and preparation method thereof | |
| CN104189223B (en) | A kind of pharmaceutical composition promoting wound healing and preparation method thereof | |
| CN114504567A (en) | Dragon's blood liquid adhesive bandage and preparation method thereof | |
| CN104922304A (en) | Externally-applied pharmaceutical composition for promoting healing of wound | |
| CN104189946B (en) | Compound recipe Radix Sanguisorbae sponge preparation and preparation method | |
| CN110302228A (en) | A kind of biological agent that treating hemorrhoid and its application | |
| CN104490970A (en) | Medicament composition for treating tinea corporis and preparation method of medicament composition | |
| CN108420877A (en) | It is a kind of to treat traumatic injury and swelling and pain relieving Chinese medicine preparation | |
| Johnson et al. | Evaluation of Ethanolic Extract of Tridax procumbens Linn on Wound Healing in Rats | |
| CN105232650A (en) | Unguent for treating scalds and preparation and application methods thereof | |
| KR20120090123A (en) | Composition of film forming solution for alleviation of menstrual cramp | |
| CN107243029A (en) | A kind of bacteriostatic lotion and its preparation method and application | |
| CN108126006A (en) | The preparation process of clinopodium polycephalum oral preparation | |
| CN106619803B (en) | External preparation for treating hemorrhoids and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Qin Xuling Inventor after: Bi Binna Inventor before: Bi Binna |
|
| CB03 | Change of inventor or designer information | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161207 |
|
| WW01 | Invention patent application withdrawn after publication |