CN106619803B - External preparation for treating hemorrhoids and preparation method thereof - Google Patents
External preparation for treating hemorrhoids and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external preparation for treating hemorrhoids and a preparation method thereof, belonging to the field of traditional Chinese medicines and comprising the following steps: dissolving 20-180 parts by weight of borax in 20-180 parts by weight of purified water to obtain solution 1, dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of ethanol to obtain solution 2; decocting semen Momordicae 20-120 weight parts with water for 0.75-1.25 hr, adding fructus Sophorae 50-250 weight parts, radix Angelicae Dahuricae 20-120 weight parts and radix Sophorae Flavescentis 20-120 weight parts, decocting for 1-2 hr, filtering, and concentrating the filtrate to obtain fluid extract; and mixing the clear paste, the solution 1 and the solution 2 with the melted ointment matrix to obtain the external preparation for treating the hemorrhoids, which has good effect of treating the hemorrhoids and can effectively treat the symptoms such as inflammation, swelling and pain bleeding or trauma ecthyma caused by the mixed hemorrhoids, bedsore caused by the anal fissure and the like.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to an external preparation for treating hemorrhoids and a preparation method thereof.
Background
Hemorrhoid (commonly called hemorrhoid) is a common disease located in anus, and can be developed at any age, but the incidence rate is gradually increased with the age. Currently, there are two main approaches to treating hemorrhoids: one is for external use, and the other is for surgical excision. The existing external medicine for treating hemorrhoids has a certain curative effect on mild hemorrhoids, but only plays a role of relieving and not radically treating hemorrhoids, and can relapse after a while, and patients have to persist in the medicine for a long time, thus being very painful. Some patients are troubled, and the medicine is abandoned step by step, so severe patients can develop after the lapse of time, and only surgical excision treatment needs to be selected. However, most hemorrhoid patients have the fear of adopting an operation mode to treat the hemorrhoid because the hemorrhoid is in a privacy sensitive part.
Disclosure of Invention
The invention aims to provide an external preparation for treating hemorrhoids, which has good effect of treating hemorrhoids and can effectively treat inflammation, swelling and pain bleeding, anal fistula, anal tube abscess caused by internal and external hemorrhoids and mixed hemorrhoids, or symptoms such as chronic unhealed wounds, bedsore and the like caused by trauma ecthyma and anal fissure.
The invention also aims to provide a preparation method of the external preparation for treating the hemorrhoids, so that the prepared external preparation for treating the hemorrhoids has good effect of treating the hemorrhoids, and can effectively treat inflammation, swelling and pain bleeding, anal fistula and anal abscess caused by internal and external hemorrhoids and mixed hemorrhoids, or symptoms such as chronic unhealed wounds, bedsores and the like caused by trauma ecthyma and anal fissure.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
An external preparation for treating hemorrhoids is prepared by mixing medicinal preparations, wherein the medicinal preparations comprise clear paste, solution 1, solution 2 and ointment matrix, the clear paste is prepared by adding water into 20-120 parts by weight of cochinchina momordica seed for decocting for 0.75-1.25h, then adding 50-250 parts by weight of sophora fruit, 20-120 parts by weight of angelica dahurica and 20-120 parts by weight of sophora flavescens for decocting for 1-2h, filtering and concentrating the filtrate;
the solution 1 is prepared by dissolving 20-180 parts by weight of borax in 20-180 parts by weight of water, and the solution 2 is prepared by dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of ethanol.
A preparation method of an external preparation for treating hemorrhoids comprises the following steps: dissolving 20-180 parts by weight of borax in 20-180 parts by weight of water to obtain solution 1, and dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of ethanol to obtain solution 2;
decocting semen Momordicae 20-120 weight parts with water for 0.75-1.25 hr, adding fructus Sophorae 50-250 weight parts, radix Angelicae Dahuricae 20-120 weight parts and radix Sophorae Flavescentis 20-120 weight parts, decocting for 1-2 hr, filtering, and collecting filtrate to obtain fluid extract;
mixing the fluid extract, solution 1 and solution 2 with melted ointment matrix, and stirring to obtain external preparation.
The external preparation for treating hemorrhoids and the preparation method thereof have the advantages that: the fructus Sophorae used in the preparation method of the external preparation for treating hemorrhoid is bitter and cold, and has effects of clearing heat and purging pathogenic fire, cooling blood and stopping bleeding, and relieving hemorrhoid hemorrhage; radix Angelicae Dahuricae has effects of promoting blood circulation, expelling pus, promoting granulation, and relieving pain; semen Momordicae has effects in treating carbuncle, sore, relieving pain, and promoting granulation; the radix sophorae flavescentis has the effects of resisting inflammation and bacteria, relieving skin itch, treating damp toxin pyocutaneous disease, promoting the absorption of skin on other drug effects and the like; borax has good bactericidal and anti-inflammatory effects; chlorhexidine acetate can treat various inflammations on skin mucosa; the external preparation for treating the hemorrhoids, which is prepared from the raw materials, has good effect of treating the hemorrhoids, and can effectively treat inflammation, swelling and pain bleeding, anal fistula and anal abscess caused by internal and external hemorrhoids and mixed hemorrhoids, or symptoms such as chronic unhealed wound, bedsore and the like caused by trauma ecthyma and anal fissure.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The external preparation for treating hemorrhoids and the method for preparing the same according to the embodiment of the present invention will be described in detail below.
The raw materials are prepared according to the raw materials, and comprise medicinal raw materials and ointment matrix. The raw materials of the medicinal materials comprise, by weight, 50-250 parts of sophora fruit, 20-120 parts of angelica dahurica, 20-120 parts of cochinchina momordica seed, 20-120 parts of sophora flavescens, 20-180 parts of borax, 5-40 parts of chlorhexidine acetate and 20-120 parts of borneol. Respectively preparing medicinal materials into clear paste, solution 1 and solution 2, and mixing with ointment matrix to obtain the external preparation for treating hemorrhoids, wherein the clear paste is prepared by adding water into 20-120 parts by weight of momordica cochinchinensis, decocting for 0.75-1.25h, adding 50-250 parts by weight of sophora fruit, 20-120 parts by weight of angelica dahurica and 20-120 parts by weight of sophora flavescens, decocting for 1-2h, filtering, and concentrating the filtrate. The solution comprises 20-180 parts by weight of borax dissolved in 20-180 parts by weight of water to obtain solution 1; 5-40 parts of chlorhexidine acetate and 20-120 parts of borneol are dissolved in 20-180 parts of ethanol to obtain solution 2.
The fructus sophorae is a good hemostatic medicinal material and can be used for treating haemorrhoid hemorrhage; radix Angelicae Dahuricae has effects of promoting blood circulation, expelling pus, promoting granulation, relieving pain, relieving skin pruritus, and treating hemorrhoid; momordicae semen, also known as: the momordicae cochinchinensis is a perennial herbaceous vine, and has the effects of diminishing swelling, resolving masses, removing toxins, treating carbuncle swelling, treating sores, hemorrhoids, innominate toxic swelling, tinea, rheumatic arthralgia and the like; the sophora flavescens is a variant of sophora flavescens in leguminosae, has good effects of diminishing inflammation, resisting bacteria and relieving skin itch, and can effectively dredge and astringe pores, remove toxin impurities in skin, promote the growth and repair of damaged vascular nerve cells and restore the activity of subcutaneous capillaries; borax, namely sodium tetraborate, has the effects of disinfecting and antisepsis, diminishing inflammation, sterilizing and the like on skin, and has obvious effect particularly on treating various sore diseases; chlorhexidine acetate, also known as robenidine, is a very effective broad-spectrum, quick-acting skin disinfectant; borneol, also known as borneol, borneol incense and the like, has good detumescence and pain-relieving effects, and has obvious effect on treating carbuncle swelling and hemorrhoids.
Further, the clear paste is prepared by adding water into 60-80 parts by weight of momordica cochinchinensis, decocting for 0.75-1.25h, adding 125-145 parts by weight of sophora fruit, 40-60 parts by weight of angelica dahurica and 60-70 parts by weight of sophora flavescens, decocting for 1-2h, filtering and concentrating the filtrate; dissolving 90-110 parts by weight of borax in 130 parts by weight of water 110-110 to obtain a solution 1; 10-30 parts by weight of chlorhexidine acetate and 70-90 parts by weight of borneol are dissolved in 70-90 parts by weight of ethanol to obtain solution 2. It is to be understood that every part by weight described in the present invention is the same, and every 1 part by weight described above may be, for example, 1g, 1Kg, etc.
It should be further noted that, because kuh-seng has the functions of removing toxic impurities in skin, promoting the growth and repair of damaged blood vessel nerve cells, and recovering the activity of subcutaneous capillaries, the addition of kuh-seng in the external preparation for treating hemorrhoids can further improve the absorption capacity of human body to other medicinal materials after administration, can further improve the capabilities of anti-inflammatory, analgesic, bactericidal, granulation promoting and the like of various medicinal materials, and can more rapidly treat inflammation, swelling and pain bleeding, anal fistula, anal abscess, or symptoms of unhealed wound, bedsore and the like caused by ecthyma and anal fissure.
The ointment base may be at least one selected from the group consisting of an oleaginous base, an emulsion base and a water-soluble base. The ointment base has a certain pasty consistency, has better solubility in water and good compatibility with medicines, and has the following advantages in order to adapt to the use of a human body: it can not cause skin allergy, and is stable and not deteriorated; can be easily removed from skin, hair and clothes; can be applied to wet skin; the ointment base itself should have the function of cleaning, drying the surface, etc.
The oleaginous base is a large class of strong hydrophobic substances, has lubricating property and no stimulation, and has softening and protecting effects on the skin; the stability is strong, the compatibility is wide, the bacteria are not easy to grow, the main components include hydrocarbons, lipids, grease and silicone, and common lanolin, glyceryl mono-distearate, vaseline, solid paraffin, liquid paraffin, lanonol, beeswax, spermaceti wax and the like are used. The emulsion type matrix is a milky semisolid matrix formed by oil phase and water phase substances through the action of an emulsifier; consists of three components of a water phase, an oil phase and an emulsifier, and is divided into a W/O type and an O/W type; the emulsifier in the emulsion matrix is surfactant, so that the matrix and skin exudate are easy to be mixed and dissolved, the action of the drug and epidermis is promoted, the release and penetration of the drug are strong, and common soap, fatty alcohol sulfate and polyol ester are used. The water soluble matrix is composed of natural or synthetic water soluble polymer, can absorb tissue exudate, has quick drug release and no irritation, can be used for moistening and eroding wound surface, but needs to be added with humectant and antiseptic to prevent evaporation and mildew, and is commonly used with glycerol, glycerogelatin, cellulose derivatives, polyethylene glycol and carbopol.
The above-mentioned concentrated filtrate can be carried out according to the following method: decocting the filtered residue in water for 0.5-1.5 hr. Filtering again to obtain a secondary liquid medicine; mixing the filtrate with the secondary medicinal liquid, and concentrating. The method extracts the residue for the second time, can effectively release effective components in the raw materials, and improve the therapeutic effect of the final external preparation for treating hemorrhoid.
Furthermore, when the momordicae semen is decocted, the momordicae semen after the shell breaking can be used, so that the effective components in the momordicae semen can be further separated out. The weight of the water added when the momordica cochinchinensis is decocted is 3-5 times of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens, which is not only beneficial to the extraction of the active ingredients in the momordica cochinchinensis, but also can ensure that the active ingredients can be quickly separated out when the sophora fruit, the angelica dahurica and the sophora flavescens are added for continuous extraction, and the liquid medicine can not be boiled to be dry when the momordica cochinchinensis is decocted, thereby avoiding the problems that the water needs to be added manually in the decocting process, a large amount of labor is spent, the liquid medicine is.
Furthermore, the weight of the added water is 3-10 times of the total weight of the cochinchina momordica seed, the sophora fruit, the angelica dahurica and the sophora flavescens during decoction of the dregs, so that residual effective components in the dregs can be further separated out, and the difficulty, the time and the like of subsequent concentration caused by excessive added water are avoided.
The above concentrated filtrate is vacuum concentrated at 50-80 deg.C under negative pressure (-0.02 MPa-0.06 MPa) of 0.02-0.06 MPa until the filtrate has density of 1.0-1.6 relative to water. By concentrating according to the above method, part of effective substances in the mixed filtrate can be prevented from being damaged or volatilized at high temperature for a long time, and the obtained fluid extract has high therapeutic effect.
The water used for the decoction, dissolution, etc. in the present invention should preferably be purified water, which is water for drug administration.
In addition, when preparing the external preparation for treating hemorrhoids, other raw materials can be added besides the preparation of clear paste, the solution 1 and the solution 2, such as: antiseptic, Chinese medicinal powder with antiinflammatory and analgesic effects; the preservative may be, for example, paraben, benzoic acid, etc.; the anti-inflammatory and analgesic traditional Chinese medicine powder can be, for example: bletilla striata powder, shinyleaf pricklyash root powder, etc.
It should be further noted that when mixing the fluid extract, solution 1, solution 2 with the melted ointment base, the temperature of the ointment base is preferably controlled to 50-90 ℃, and the adding sequence can be preferably that the fluid extract is added first, after the fluid extract and the ointment base are mixed uniformly, solution 1, solution 2 are added into the mixture, and the mixture is stirred while being added. The addition method and the temperature of the ointment matrix can ensure that the ointment matrix and the clear paste are mixed more uniformly, and the clear paste is wrapped in the ointment matrix, so that the clear paste can be effectively ensured not to be rotten in the ointment matrix, namely the effectiveness of the clear paste in the ointment matrix for treating the hemorrhoids is ensured; further, other raw materials are mixed, for example: the temperature of the mixture is 50-90 ℃ when the preservative, the medicinal powder and the like are mixed, so that the medicinal powder, the preservative and the like in other raw materials can be effectively wrapped in the mixture of the ointment preparation and the clear paste, the preservative effect of the preservative can be fully exerted, and meanwhile, the other medicinal powder is wrapped in the mixture prepared by the ointment matrix, the clear paste and the like, and the effectiveness of the medicinal powder in the ointment matrix for treating the hemorrhoids is further ensured.
It should be further noted that the fluid extract, solution 1, solution 2 and ointment base are mixed, and the total weight of the final external preparation for treating hemorrhoids can be made up to 1000 parts by using ointment base, and then the mixture is uniformly mixed and cooled.
The external preparation for treating hemorrhoids and the preparation method thereof according to the present invention will be described in further detail with reference to examples.
Example 1
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
firstly, 72g of momordica cochinchinensis, 138g of sophora fruit, 48g of angelica dahurica, 65g of sophora flavescens, 100g of borax, 20g of chlorhexidine acetate, 80g of borneol, 20g of purified water, 80g of ethanol and a proper amount of silicon dioxide are prepared.
Firstly, breaking the shell of the momordica cochinchinensis, adding 5 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1 hour, adding the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1.5 hours, filtering, collecting filtrate, adding 6 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens into dregs, decocting for 1 hour, filtering again, and collecting secondary liquid medicine. Mixing the filtrate and the secondary filtrate, and concentrating until the density of the filtrate relative to water is 1.6 to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Heating lanolin to 80 deg.C for melting, heating glyceryl mono-distearate to 80 deg.C for melting, filtering glycerol with 200 mesh sieve, mixing the above three matrixes, stirring until the temperature is reduced to 50 deg.C, sequentially adding the fluid extract, solution 1 and solution 2, stirring uniformly, quantifying with silicon dioxide to 1000g, and cooling to obtain external preparation for treating hemorrhoid.
Example 2
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
120g of momordica cochinchinensis, 50g of sophora fruit, 20g of angelica dahurica, 120g of sophora flavescens, 20g of borax, 40g of chlorhexidine acetate, 20g of borneol, 180g of purified water and 180g of ethanol are prepared.
Firstly, breaking the shell of the momordica cochinchinensis, adding 3 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens to decoct for 0.75h, then adding the sophora fruit, the angelica dahurica and the sophora flavescens to decoct for 1h, filtering, collecting filtrate, adding 10 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens to the dregs of a decoction to decoct for 1.5h, filtering again, and collecting secondary liquid medicine. Mixing the filtrate and the secondary filtrate, and vacuum concentrating at 50 deg.C and 0.02MPa until the density of the filtrate relative to water is 1.0 to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Melting lanolin as ointment base, sequentially adding the fluid extract, solution 1 and solution 2 at lanolin temperature of 90 deg.C, stirring, adding the other materials at the same time, stirring, quantifying with lanolin to 1000g, and cooling to obtain external preparation for treating hemorrhoid.
Example 3
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
firstly, 20g of cochinchina momordica seed, 250g of sophora fruit, 120g of angelica dahurica, 20g of sophora flavescens, 180g of borax, 5g of chlorhexidine acetate, 120g of borneol, 110g of purified water and 90g of ethanol are prepared.
Firstly, breaking the shell of the momordica cochinchinensis, adding 4 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1.25h, adding the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 2h, filtering, collecting filtrate, adding 3 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens into dregs, decocting for 0.5h, filtering again, and collecting secondary liquid medicine. Mixing the filtrate and the secondary filtrate, and vacuum concentrating at 80 deg.C under 0.06MPa until the density of the filtrate relative to water is 1.6 to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Melting fatty alcohol as ointment matrix, adding the fluid extract, solution 1 and solution 2 at 60 deg.C, stirring, adding other materials at the above temperature, stirring, quantifying with fatty alcohol to 1000g, and cooling to obtain external preparation for treating hemorrhoid.
Example 4
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
firstly, 60g of momordica cochinchinensis, 145g of sophora fruit, 60g of angelica dahurica, 60g of sophora flavescens, 90g of borax, 30g of chlorhexidine acetate, 70g of borneol, 130g of purified water and 20g of ethanol are prepared.
Firstly, breaking the shell of the momordica cochinchinensis, adding 4 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1.2h, adding the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1.2h, filtering, collecting filtrate, adding 8 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens into dregs, decocting for 1.2h, filtering again, and collecting secondary liquid medicine. Mixing the filtrate and the secondary filtrate, and vacuum concentrating at 60 deg.C under 0.04MPa until the density of the filtrate relative to water is 1.4 to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Melting ointment matrix carbopol, adding the fluid extract, solution 1 and solution 2 at 65 deg.C, stirring, adding other materials at the above temperature, stirring, quantifying to 1000g with carbopol, and cooling to obtain external preparation for treating hemorrhoid.
Example 5
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
firstly, 80g of cochinchina momordica seed, 125g of sophora fruit, 40g of angelica dahurica, 40g of sophora flavescens, 110g of borax, 10g of chlorhexidine acetate, 90g of borneol, 150g of purified water and 70g of ethanol are prepared.
Firstly, breaking the shell of the momordica cochinchinensis, adding 5 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 0.9h, adding the sophora fruit, the angelica dahurica and the sophora flavescens, decocting for 1.8h, filtering, collecting filtrate, adding 5 times of water of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens into dregs, decocting for 0.8h, filtering again, and collecting secondary liquid medicine. Mixing the filtrate and the secondary filtrate, and vacuum concentrating at 70 deg.C under 0.05MPa until the density of the filtrate relative to water is 1.2 to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Melting ointment matrix Cera flava, sequentially adding fluid extract solution 1 and solution 2 at Cera flava temperature of 70 deg.C, stirring, adding other materials at the above temperature, stirring, quantifying with Cera flava to 1000g, and cooling to obtain external preparation for treating hemorrhoid.
Example 6
The preparation method of the external preparation for treating hemorrhoids provided by the embodiment comprises the following steps:
firstly, 75g of cochinchina momordica seed, 135g of sophora fruit, 50g of angelica dahurica, 70g of sophora flavescens, 95g of borax, 20g of chlorhexidine acetate, 70g of borneol, 120g of purified water and 80g of ethanol are prepared.
Breaking shell of semen Momordicae, adding 5 times of water of semen Momordicae, fructus Sophorae, radix Angelicae Dahuricae, and radix Sophorae Flavescentis, decocting for 0.8 hr, adding fructus Sophorae, radix Angelicae Dahuricae, and radix Sophorae Flavescentis, decocting for 1.9 hr, filtering, collecting filtrate, and vacuum concentrating the filtrate at 55 deg.C and 0.03MPa until its density is 1.3 relative to water to obtain fluid extract.
Dissolving borax in purified water to obtain a solution 1; dissolving chlorhexidine acetate and Borneolum Syntheticum in ethanol to obtain solution 2.
Melting ointment matrix Cera flava, fatty alcohol sulfate and glycerogelatin, adding the fluid extract, solution 1 and solution 2 at 50 deg.C, stirring, adding the above materials at the same time, stirring, quantifying with Cera flava to 1000g, and cooling to obtain external preparation for treating hemorrhoid.
The therapeutic effects of the external preparations for treating hemorrhoids prepared in examples 1, 2, 3, 4, 5, and 6 were compared with those of a control group, which was a commercially available hemorrhoid ointment, on patients with hemorrhoids.
210 patients with hemorrhoids were screened at Hospital 4, and the group was observed one week before the test, and symptoms and changes were recorded, and randomly divided into 7 groups of 30 patients, each group using the external hemorrhoid treatment preparations of examples 1 to 6 of the present invention and a control group of commercially available hemorrhoid ointments, respectively.
The judgment standard of the curative effect condition is as follows: the ulcer surface disappears after healing, the bleeding is stopped, the defecation is normal, and the recurrence is avoided within three months; the method has the following advantages: after use, the discomfort symptom is obviously improved; and (4) invalidation: after the application, the discomfort symptoms are unchanged and relapse within three months. The results are shown in Table 1.
TABLE 1 comparison of the results of the treatment of hemorrhoids in the test groups
The results in the table show that the external preparation for treating hemorrhoids has obviously better effect on treating hemorrhoids than the commercially available hemorrhoids ointment, and the external preparation for treating hemorrhoids has high cure rate, extremely low recurrence rate and outstanding effect on treating hemorrhoids.
In conclusion, the external preparation for treating hemorrhoids prepared by the preparation method provided by the embodiment of the invention has a good effect of treating hemorrhoids, and can effectively treat inflammation, swelling and pain bleeding, anal fistula and anal abscess caused by internal and external hemorrhoids and mixed hemorrhoids, or symptoms such as chronic unhealed wounds and bedsores caused by trauma ecthyma and anal fissure.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (7)
1. An external preparation for treating hemorrhoids is characterized in that the external preparation is prepared by mixing medicinal preparations, wherein the medicinal preparations comprise clear paste, solution 1, solution 2 and ointment matrix, the clear paste is prepared by adding water into 20-120 parts by weight of cochinchina momordica seed for decocting for 0.75-1.25h, then adding 50-250 parts by weight of sophora fruit, 20-120 parts by weight of angelica root and 20-120 parts by weight of sophora flavescens, decocting for 1-2h, filtering and concentrating the filtrate;
the solution 1 is prepared by dissolving 20-180 parts by weight of borax in 20-180 parts by weight of water, and the solution 2 is prepared by dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of ethanol.
2. The external preparation for treating hemorrhoids as claimed in claim 1, wherein the fluid extract is prepared by decocting semen Momordicae 60-80 weight parts with water for 0.75-1.25h, adding fructus Sophorae 125-145 weight parts, radix Angelicae Dahuricae 40-60 weight parts and radix Sophorae Flavescentis 60-70 weight parts, decocting for 1-2h, filtering, and concentrating the filtrate.
3. The external preparation for treating hemorrhoids as claimed in claim 1, wherein the solution 1 is prepared by dissolving 90-110 weight parts of borax in 130 weight parts of water, and the solution 2 is prepared by dissolving 10-30 weight parts of chlorhexidine acetate and 70-90 weight parts of borneol in 70-90 weight parts of ethanol.
4. The external preparation for treating hemorrhoids as claimed in any one of claims 1 to 3, wherein the ointment base is at least one selected from the group consisting of oleaginous base, emulsion base and water-soluble base.
5. A preparation method of an external preparation for treating hemorrhoids is characterized by comprising the following steps: dissolving 20-180 parts by weight of borax in 20-180 parts by weight of water to obtain solution 1, and dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of ethanol to obtain solution 2;
decocting semen Momordicae 20-120 weight parts with water for 0.75-1.25 hr, adding fructus Sophorae 50-250 weight parts, radix Angelicae Dahuricae 20-120 weight parts and radix Sophorae Flavescentis 20-120 weight parts, decocting for 1-2 hr, filtering, and collecting filtrate; decocting the residue in water for 0.5-1.5 hr, and filtering again to obtain secondary medicinal liquid; mixing the filtrate with the secondary liquid medicine and then concentrating; concentrating under vacuum at 50-80 deg.C and 0.02-0.06 MPa to obtain filtrate with density of 1.0-1.6 relative to water to obtain fluid extract;
mixing and stirring the clear paste, the solution 1 and the solution 2 with the melted ointment base to obtain the external preparation;
wherein, when the clear paste, the solution 1, the solution 2 and the melted ointment matrix are mixed, the temperature of the ointment matrix is 50-90 ℃.
6. The method of preparing an external preparation for treating hemorrhoids as claimed in claim 5, wherein the weight of the water added when decocting the momordicae semen is 3-5 times of the total weight of the momordicae semen, the sophora fruit, the angelica dahurica and the sophora flavescens.
7. The method for preparing an external preparation for treating hemorrhoids as claimed in claim 5, wherein the weight of the water added when decocting the residue is 3-10 times of the total weight of the momordica cochinchinensis, the sophora fruit, the angelica dahurica and the sophora flavescens.
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| CN1229651A (en) * | 1998-03-23 | 1999-09-29 | 周彬 | Haemorrhoids powder |
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