CN106619803A - External preparation for treating haemorrhoids and preparation method thereof - Google Patents
External preparation for treating haemorrhoids and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external preparation for treating haemorrhoids and a preparation method thereof and belongs to the field of traditional Chinese medicines. The method comprises the following steps: dissolving 20-180 parts by weight of borax in 20-180 parts by weight of purified water to obtain a solution 1,and simultaneously dissolving 5-40 parts by weight of chlorhexidine acetate and 20-120 parts by weight of borneol in 20-180 parts by weight of alcohol to obtain a solution 2; decocting 20-120 parts by weight of semen momordicae with water for 0.75-1.25 hours, then adding 50-250 parts by weight of fructus sophorae, 20-120 parts by weight of radix angelicae dahuricae and 20-120 parts by weight of radix sophorae flavescentis, decocting for 1-2 hours, then filtering, and concentrating filtrate to obtain clear ointment; mixing the clear ointment, the solution 1 and the solution 2 with a fused ointment base to obtain the external preparation for treating haemorrhoids. The external preparation has an excellent effect of treating haemorrhoids and is capable of effectively treating symptoms such as inflammation, swelling and bleeding or trauma ecthyma and bedsore caused by anal fissure and the like caused by internal and external hemorrhoids and mixed hemorrhoids.
Description
Technical field
The present invention relates to the field of Chinese medicines, and more particularly to treat external preparation of hemorrhoid and preparation method thereof.
Background technology
Hemorrhoid (being commonly called as hemorrhoid) are a kind of common diseases positioned at anus area, and any age all can fall ill, but with the age
Increase, the incidence of disease gradually increases.At present, treat hemorrhoid mainly has two kinds by the way of：One kind is externally applied drug, and another kind is exactly
Surgery excision.The externally applied drug of existing treatment hemorrhoid, though having certain curative effect to mild hemorrhoid, has only served the work alleviated
With, and radical cure effect is not had, and cure the symptoms, not the disease, crossing shortly can recur, and patient has to adhere to medication for a long time, very pain
It is bitter.Some patients do not want to take the trouble, and progressively abandon medication, As time goes on will develop into patient with severe symptoms, have to select hand
Art excision treatment.But for most of hemorrhoid patients, because hemorrhoid are in privacy-sensitive position, for taking modus operandi
Treatment all has certain scruples.
The content of the invention
It is an object of the invention to provide a kind of external preparation for treating hemorrhoid, it has the work of good treatment hemorrhoid
With the inflammation for causing of inside and outside hemorrhoid and mixed hemorrhoids, bleeding of swelling and ache, anal fistula, anal tube abscess, or wound shank can be effectively treated
The symptoms such as not closing up long caused by sore, anal fissure, bedsore.
Another object of the present invention is to a kind of preparation method of the external preparation for treating hemorrhoid is provided, so that obtained
The external preparation for the treatment of hemorrhoid has the effect of good treatment hemorrhoid, can effectively treat inside and outside hemorrhoid and mixed hemorrhoids draw
Inflammation, bleeding of swelling and ache, anal fistula, the anal tube abscess for rising, or the symptom such as not closing up long caused by wound ulcer on the shank, anal fissure, bedsore.
The present invention solves its technical problem and employs the following technical solutions to realize.
A kind of external preparation for treating hemorrhoid, it is mixed by pharmaceutical preparation, and pharmaceutical preparation includes clear cream, solution 1, molten
Liquid 2 and ointment bases, clear cream adds water to cook 0.75-1.25h by the semen momordicae of 20-120 weight portions, adds 50-250 weight portions
The Fructus Sophorae, the root of Dahurain angelica of 20-120 weight portions and 20-120 weight portions kuh-seng decoct 1-2h after filter, concentrate filtrate and obtain；
Solution 1 is dissolved in the water of 20-180 weight portions for the borax of 20-180 weight portions, and solution 2 is the acetic acid of 5-40 weight portions
The borneol of Chlorhexidine and 20-120 weight portions is dissolved in the ethanol of 20-180 weight portions.
A kind of preparation method of the external preparation for treating hemorrhoid, comprises the following steps：The borax of 20-180 weight portions is molten
Solution 1 is obtained in the water of 20-180 weight portions, the borneol of the chlorhexidine acetate of 5-40 weight portions and 20-120 weight portions is dissolved in into 20-
Solution 2 is obtained in the ethanol of 180 weight portions；
The semen momordicae of 20-120 weight portions is added water to cook into 0.75-1.25h, the Fructus Sophorae, the 20- of 50-250 weight portions is added
The root of Dahurain angelica of 120 weight portions and the kuh-seng of 20-120 weight portions decocted and filtered after 1-2h, are collected filtrate and are obtained clear cream；
Clear cream, solution 1 and solution 2 are mixed with the ointment bases after fusing, external preparation is obtained.
The beneficial effect of the external preparation for the treatment of hemorrhoid of the embodiment of the present invention and preparation method thereof is：The treatment hemorrhoid
Fructus Sophorae bitter cold used in the preparation method of external preparation, the work of bleeding of swelling with clearing heat-fire, cooling blood and hemostasis, alleviation hemorrhoid
With；There is the root of Dahurain angelica apocenosis of invigorating blood circulation, myogenic pain relieving etc. to act on；Semen momordicae has treatment carbuncle swells, treats the effect such as sore, pain relieving, myogenic；It is bitter
Ginseng has the effects such as the absorption of anti-inflammatory, antibacterial, alleviation pruitus, treatment wet poison sore, promotion skin to other drug effects；Borax
Effect with good sterilization, anti-inflammatory；Chlorhexidine acetate can treat the various inflammation on skin and mucosa；Use above-mentioned raw material
The external preparation of the treatment hemorrhoid for preparing has the effect of good treatment hemorrhoid, can effectively treat inside and outside hemorrhoid and mix
Close the hemorrhoid inflammation for causing, bleeding of swelling and ache, anal fistula, anal tube abscess, or not closing up long caused by wound ulcer on the shank, anal fissure, bedsore
Etc. symptom.
Specific embodiment
To make purpose, technical scheme and the advantage of the embodiment of the present invention clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can pass through the conventional product that commercially available purchase is obtained
Product.
External preparation for the treatment of hemorrhoid of the embodiment of the present invention and preparation method thereof is specifically described below.
Got the raw materials ready according to raw material, including medicinal raw material and ointment bases.Medicinal raw material by weight, including the Fructus Sophorae
50-250 parts, root of Dahurain angelica 20-120 parts, semen momordicae 20-120 parts, kuh-seng 20-120 parts, borax 20-180 parts, chlorhexidine acetate 5-40
Part, borneol 20-120 parts.Medicinal raw material is prepared respectively clear cream and solution 1, solution 2, then this is mixed to prepare with ointment bases
The external preparation for the treatment of hemorrhoid, above-mentioned clear cream is to add water to cook 0.75-1.25h by the semen momordicae of 20-120 weight portions, is added
The kuh-seng of the Fructus Sophorae, the root of Dahurain angelica of 20-120 weight portions and 20-120 weight portions of 50-250 weight portions decocted and filtered after 1-2h, concentration
Filtrate and obtain.Above-mentioned solution includes that the borax of 20-180 weight portions is dissolved in the water of 20-180 weight portions and obtains solution 1；5-40 weights
The chlorhexidine acetate of amount part and the borneol of 20-120 weight portions are dissolved in the ethanol of 20-180 weight portions and obtain solution 2.
The Fructus Sophorae is a kind of good hemostasis medicinal material, can be used for treating hemorrhoid hemorrhage；There is the root of Dahurain angelica apocenosis of invigorating blood circulation, myogenic to stop
Bitterly, the effects such as alleviating pruitus, treatment intestines wind anal fistula；Semen momordicae, also known as：Momordica cochinchiensis rattan, is a kind of herbaceous perennial vine, tool
There are dispersing swelling and dissipating binds, toxic removing, control carbuncle swells, treat the effect such as sore, hemorrhoid, nameless sores or boils, tinea sore, arthralgia due to wind-dampness；Kuh-seng is pulse family kuh-seng
The mutation of category, alleviates the effect of pruitus, and can effectively dredge and restrain pore with good anti-inflammatory, antibacterial,
The toxin impurity in skin is removed, promotes nervus vasculairs cell growth and the reparation being damaged, recover subcutaneous capillary vigor；Boron
Sand, i.e. sodium tetraborate, with acting on skin degerming anti-corrosion, anti-inflammation and sterilization etc., particularly for treating the effect of various sore diseases
Substantially；Chlorhexidine acetate, also known as Robenidine Roripa, are a kind of highly effective wide spectrum, quick-acting skin antiseptics；Borneol, You Minglong
Brain, kapur etc., act on good swelling and pain relieving, obvious for treatment carbuncle swells, the effect of hemorrhoid.
Further, above-mentioned clear cream adds water to cook 0.75-1.25h by the semen momordicae of 60-80 weight portions, adds 125-
The kuh-seng of the Fructus Sophorae, the root of Dahurain angelica of 40-60 weight portions and 60-70 weight portions of 145 weight portions decocted and filtered after 1-2h, concentrate filtrate and
；The borax of 90-110 weight portions is dissolved in the water of 110-130 weight portions and obtains solution 1；The acetic acid chlorine of 10-30 weight portions oneself
The borneol of fixed and 70-90 weight portions is dissolved in the ethanol of 70-90 weight portions and obtains solution 2.It should be appreciated that heretofore described
Each weight portion is identical, and above-mentioned every 1 weight portion for example can be 1g, 1Kg etc..
Need it is further noted that because kuh-seng has the toxin impurity removed in skin, promotes impaired blood vessel god
Jing cell growths and reparation, the effect for recovering subcutaneous capillary vigor, so, add in the external preparation of the treatment hemorrhoid
Kuh-seng, can further improve human body after medication to the absorbability of other medicinal raw materials, can further improve each
The ability of anti-inflammatory analgetic, sterilization, the myogenic of medicinal raw material etc. is planted, inside and outside hemorrhoid can be more quickly treated and mixed hemorrhoids is caused
Inflammation, bleeding of swelling and ache, anal fistula, anal tube abscess, or the symptom such as not closing up long caused by wound ulcer on the shank, anal fissure, bedsore.
Above-mentioned ointment bases can for example be selected from least in oleaginous base, emulsion-type matrix and water-soluble base
Kind.Ointment bases has certain creamlike consistency, there is reasonable dissolubility and good and drug compatibility in water, in order to
Adapt to human body to use, ointment bases there should be advantages below：Can not cause allergic, and stably never degenerate；Can easily from
Remove on skin, hair and clothing；Go on moist skin；Ointment bases itself will play the role of cleaning, be dried surface
Deng.
Oleaginous base is a big class strong-hydrophobicity material, non-stimulated with lubricity, has softening protection to make to skin
With；Stability is strong, compatibility is wide, not easy bacteria-developing, and mainly including four kinds of hydro carbons, lipoidis, grease type and silicone, conventional has
Lanolin, list-bi-tristearin, vaseline, solid paraffin, atoleine, lanonol, beeswax, spermaceti etc..Emulsion-type base
Matter system oil phase borrows the emulsus semisolid matrix of the effect composition of emulsifying agent with aqueous phase substance；By water phase, oil phase and emulsifying agent three
Component composition is planted, is divided into w/o type and the class of O/W types two；Emulsifying agent in emulsion-type matrix mostly is surfactant, thus is easy to make
Matrix and skin exudates are miscible, promote the effect of medicine and epidermis, make the release of medicine, penetrate relatively by force, and conventional has fertilizer
Soaps, fatty alcohol, fatty alcohol sulphuric acid esters, polyalcohol esters.Water-soluble base is by naturally occurring or synthetic water soluble polymer
Matter is constituted, can absorptive tissue diffusate, drug release is very fast, non-stimulated, can be used to moistening, the rotten to the corn surface of a wound, but need plus NMF and
Preservative, to prevent from evaporating and go mouldy, conventional has glycerine, glycerin gelatine, cellulose derivative, polyethylene glycol, carbopol.
Above-mentioned concentration filtrate can be carried out in accordance with the following methods：The dregs of a decoction after filtration are added water to cook into 0.5-1.5h.Again
It is secondary to be filtrated to get secondary liquid；To concentrate after filtrate and the mixing of secondary liquid.The method has carried out second to the dregs of a decoction and has refined, can
Effectively further to disengage the active ingredient in medicinal raw material, the hemorrhoid treating medicine of last obtained external preparation is improved
Effect.
Further, when decocting semen momordicae, it is possible to use the semen momordicae after broken shell, so can make effective in semen momordicae
Composition is further separated out.The weight for decocting the water added during semen momordicae is the gross weight of semen momordicae, the Fructus Sophorae, the root of Dahurain angelica and kuh-seng
3-5 times, not only contribute to the extraction of the active ingredient in semen momordicae, it can also be ensured that the addition Fructus Sophorae, the root of Dahurain angelica and kuh-seng after
Continuous active ingredient when extracting can be separated out quickly, and will not boil dry liquid when decocting, it is to avoid infusion process needs people
Work adds water, and spends substantial amounts of artificial, is more that of avoiding and for liquid to endure paste, and reduces drug effect etc..
Further, the weight of the water added when decocting the dregs of a decoction is the gross weight of semen momordicae, the Fructus Sophorae, the root of Dahurain angelica and kuh-seng
3-10 times, both further active ingredient remaining in the dregs of a decoction can be separated out, turn avoid the dilutional hyponatremia of addition increases follow-up
Difficulty, time of concentration etc..
Above-mentioned concentration filtrate be temperature be 50-80 DEG C, pressure be 0.02MPa -0.06MPa negative pressure (-
0.02MPa--0.06MPa) under the conditions of be concentrated in vacuo to the filtrate relative to water density be 1.0-1.6.According to above-mentioned side
Method is concentrated, and can avoid the part active principle in the filtrate for mixing, and is destroyed or substantial amounts of at a high temperature of long-time
Volatilization loss etc., it is ensured that obtained clear cream has efficient therapeutic effect.
The water that decoction, dissolving etc. are used in the present invention should preferably adopt purified water, and it is hyoscine water.
It should be noted that when the external preparation of the treatment hemorrhoid is prepared, except prepare clear cream, solution 1 and solution 2 it
Outward, other raw materials can also be added, for example：Preservative, herb powder of anti-inflammatory analgetic etc.；Foregoing preservatives for example can be Buddhist nun
The golden ester of pool, benzoic acid etc.；The herb powder of above-mentioned anti-inflammatory analgetic for example can be：Common bletilla, shinyleaf pricklyash root powder etc..
Need it is further noted that by clear cream, solution 1, solution 2 with melt after ointment bases mix when, ointment base
The temperature of matter is preferably controlled to 50-90 DEG C, and the order for adding preferably can first add clear cream, and clear cream and ointment bases are being mixed
After closing uniformly, then solution 1, solution 2 are added into above-mentioned mixture, and added while stirring.Above-mentioned addition side
The temperature of method and ointment bases, can make the more uniform of ointment bases and clear cream mixing, clear cream is wrapped in ointment bases,
Effectively ensure that clear cream will not addle in ointment bases, that is, ensure that clear cream is effective for treatment hemorrhoid in ointment bases
Property；Further, other raw materials are mixed into, for example：Preservative, medicinal powder etc., the temperature of mixture is 50-90 DEG C when being mixed into, thus,
The medicinal powder in other raw materials, preservative etc. can be made effectively to be wrapped among the mixture of ointment formulation and clear cream, can be with
The antiseptic effect of preservative is given full play to, while making other medicinal powder be wrapped in mixture obtained in ointment bases and clear cream etc.
In, further ensure that medicinal powder in ointment bases for the validity for the treatment of hemorrhoid.
Need it is further noted that clear cream, solution 1, solution 2 and ointment bases are mixed, the treatment hemorrhoid for finally obtaining
The gross weight of the external preparation of sore, can supply 1000 parts with ointment bases, mix, cool down.
Make further detailed to external preparation for the treatment of hemorrhoid of the invention and preparation method thereof with reference to embodiments
Description.
Embodiment 1
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 138g, the root of Dahurain angelica of 48g, the kuh-seng of 65g, the borax of 100g, the acetic acid of 20g of 72g
Chlorhexidine, the borneol of 80g, purified water 20g, ethanol 80g, appropriate silica.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 5 times of the gross weight of kuh-seng of decocting and boil
1h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 1.5h, and filtrate is collected after filtration, and above-mentioned semen momordicae, Chinese scholartree are added in the dregs of a decoction
Angle, the root of Dahurain angelica, 6 times of the gross weight of kuh-seng of decocting boil 1h, filter again, collect secondary liquid.Filtrate and secondary filtrate are closed
And after, concentration, until it is 1.6 relative to the density of water, obtains clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
Lanolin is heated into 80 DEG C of thawings, list-bi-tristearin is heated into 80 DEG C of thawings, glycerine is used
200 mesh screens, by the mixing of above-mentioned three kinds of matrix, stir to temperature be reduced to 50 DEG C when, sequentially add clear cream and solution 1, molten
Liquid 2, and stir respectively, finally must treat the external preparation of hemorrhoid quantitatively to 1000g, cooling with silica.
Embodiment 2
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 50g, the root of Dahurain angelica of 20g, the kuh-seng of 120g, the borax of 20g, the acetic acid of 40g of 120g
Chlorhexidine, the borneol of 20g, purified water 180g, ethanol 180g.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 3 times of the gross weight of kuh-seng of decocting and boil
0.75h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 1h, and filtrate is collected after filtration, and above-mentioned semen momordicae, Chinese scholartree are added in the dregs of a decoction
Angle, the root of Dahurain angelica, 10 times of the gross weight of kuh-seng of decocting boil 1.5h, filter again, collect secondary liquid.By filtrate and secondary filtrate
It it is 50 DEG C in temperature after merging, pressure is concentrated in vacuo under 0.02MPa condition of negative pressure, until it is relative to the density of water
1.0, obtain clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
By the fusing of ointment bases lanolin, when the temperature of lanolin is 90 DEG C, clear cream, solution 1, solution 2 are sequentially added,
And stir respectively, continuation at the temperature disclosed above adds other raw materials, while stir, and is finally determined with lanolin
Measure to 1000g, cooling, the external preparation of hemorrhoid must be treated.
Embodiment 3
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 250g, the root of Dahurain angelica of 120g, the kuh-seng of 20g, the borax of 180g, the acetic acid of 5g of 20g
Chlorhexidine, the borneol of 120g, purified water 110g, ethanol 90g.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 4 times of the gross weight of kuh-seng of decocting and boil
1.25h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 2h, and filtrate is collected after filtration, and above-mentioned semen momordicae, Chinese scholartree are added in the dregs of a decoction
Angle, the root of Dahurain angelica, 3 times of the gross weight of kuh-seng of decocting boil 0.5h, filter again, collect secondary liquid.By filtrate and secondary filtrate
It it is 80 DEG C in temperature after merging, pressure is concentrated in vacuo under 0.06MPa condition of negative pressure, until it is relative to the density of water
1.6, obtain clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
By the fusing of ointment bases fatty alcohol, when the temperature of fatty alcohol is 60 DEG C, clear cream, solution 1, solution 2 are added, and stirred
Mix uniform, continuation at the temperature disclosed above adds other raw materials, while stir, finally fatty alcohol with quantitatively extremely
1000g, cooling, must treat the external preparation of hemorrhoid.
Embodiment 4
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 145g, the root of Dahurain angelica of 60g, the kuh-seng of 60g, the borax of 90g, the acetic acid of 30g of 60g
Chlorhexidine, the borneol of 70g, purified water 130g, ethanol 20g.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 4 times of the gross weight of kuh-seng of decocting and boil
1.2h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 1.2h, and filtrate is collected after filtration, and above-mentioned semen momordicae, Chinese scholartree are added in the dregs of a decoction
Angle, the root of Dahurain angelica, 8 times of the gross weight of kuh-seng of decocting boil 1.2h, filter again, collect secondary liquid.By filtrate and secondary filtrate
It it is 60 DEG C in temperature after merging, pressure is concentrated in vacuo under 0.04MPa condition of negative pressure, until it is relative to the density of water
1.4, obtain clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
By the fusing of ointment bases carbopol, when the temperature of carbopol is 65 DEG C, clear cream, solution 1, solution 2 are added, and stirred
Mix uniform, continuation at the temperature disclosed above adds other raw materials, while stir, finally carbopol with quantitatively extremely
1000g, cooling, must treat the external preparation of hemorrhoid.
Embodiment 5
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 125g, the root of Dahurain angelica of 40g, the kuh-seng of 40g, the borax of 110g, the acetic acid of 10g of 80g
Chlorhexidine, the borneol of 90g, purified water 150g, ethanol 70g.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 5 times of the gross weight of kuh-seng of decocting and boil
0.9h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 1.8h, and filtrate is collected after filtration, and above-mentioned semen momordicae, Chinese scholartree are added in the dregs of a decoction
Angle, the root of Dahurain angelica, 5 times of the gross weight of kuh-seng of decocting boil 0.8h, filter again, collect secondary liquid.By filtrate and secondary filtrate
It it is 70 DEG C in temperature after merging, pressure is concentrated in vacuo under 0.05MPa condition of negative pressure, until it is relative to the density of water
1.2, obtain clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
By the fusing of ointment bases beeswax, when the temperature of beeswax is 70 DEG C, clear cream solution 1, solution 2 are sequentially added, and stirred
Mix uniform, continuation at the temperature disclosed above adds other raw materials, while stir, finally with beeswax quantitatively to 1000g,
Cooling, must treat the external preparation of hemorrhoid.
Embodiment 6
A kind of external preparation for treating hemorrhoid that the present embodiment is provided, its method for preparing comprises the following steps：
First prepare semen momordicae, the Fructus Sophorae of 135g, the root of Dahurain angelica of 50g, the kuh-seng of 70g, the borax of 95g, the acetic acid of 20g of 75g
Chlorhexidine, the borneol of 70g, purified water 120g, ethanol 80g.
First by semen momordicae broken shell, then add above-mentioned semen momordicae, the Fructus Sophorae, the root of Dahurain angelica, 5 times of the gross weight of kuh-seng of decocting and boil
0.8h, adds the Fructus Sophorae, the root of Dahurain angelica and kuh-seng and decocts 1.9h, and filtrate is collected after filtration, in temperature is 55 DEG C by filtrate, and pressure is
It is concentrated in vacuo under 0.03MPa condition of negative pressure, until it is 1.3 relative to the density of water, obtain clear cream.
Borax is dissolved in purified water and obtains solution 1；Chlorhexidine acetate and borneol are dissolved in ethanol and obtain solution 2.
Ointment bases beeswax, fatty alcohol sulfate and glycerin gelatine are melted, it is bright in beeswax, fatty alcohol sulfate and glycerine
When the temperature of the mixture of glue is 50 DEG C, clear cream, solution 1, solution 2 are added, and stirred, continued at the temperature disclosed above by original
Material adds, while stir, finally cooled down quantitatively to 1000g with beeswax, the external preparation of hemorrhoid must be treated.
The treatment hemorrhoid that relatively prepared by the above embodiments 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6
For the therapeutic effect of hemorrhoid patients, above-mentioned control group is commercially available acne cream to the external preparation and control group of sore.
210 sufferers with hemorrhoid are screened in 4 hospitals, before a week of test, the crowd is observed, recorded
Symptom and change, are randomly divided into 7 groups, per group of 30 people, per group respectively using embodiment of the present invention 1-6 treatment hemorrhoid external application system
Agent and the commercially available acne cream of control group.
Curative effect situation criterion：Cure, ulcer surface disappears, hemostasis, defecation are normal, and without recurrence feelings in three months
Condition；Effectively：It is obviously improved with rear malaise symptoms；It is invalid：It is unchanged using rear malaise symptoms, recur in three months.The results are shown in Table
1。
The effect of each test group of table 1 treatment hemorrhoid compares
From the result of upper table, the external preparation of the treatment hemorrhoid of the present invention is substantially better than city in the effect for the treatment of hemorrhoid
The acne cream sold, the cure rate of the external preparation treatment of the treatment hemorrhoid of the present invention is high, and recurrence rate is extremely low, in the effect for the treatment of hemorrhoid
Fruit is prominent.
In sum, the external preparation for the treatment of hemorrhoid prepared by the preparation method of the embodiment of the present invention, it has good
The effect for the treatment of hemorrhoid, can effectively treat the inflammation for causing of inside and outside hemorrhoid and mixed hemorrhoids, bleeding of swelling and ache, anal fistula, anal tube
Abscess, or the symptom such as not closing up long caused by wound ulcer on the shank, anal fissure, bedsore.
Embodiments described above is a part of embodiment of the invention, rather than the embodiment of whole.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected enforcement of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of external preparation for treating hemorrhoid, it is characterised in that it is mixed by pharmaceutical preparation, and the pharmaceutical preparation includes
Clear cream, solution 1, solution 2 and ointment bases, the clear cream adds water to cook 0.75-1.25h by the semen momordicae of 20-120 weight portions,
The kuh-seng for adding the Fructus Sophorae, the root of Dahurain angelica of 20-120 weight portions and 20-120 weight portions of 50-250 weight portions decocts mistake after 1-2h
Filter, concentrates filtrate and obtains；
The solution 1 is dissolved in the water of 20-180 weight portions for the borax of 20-180 weight portions, and the solution 2 is 5-40 weight portions
The borneol of chlorhexidine acetate and 20-120 weight portions is dissolved in the ethanol of 20-180 weight portions.
2. it is according to claim 1 treatment hemorrhoid external preparation, it is characterised in that the clear cream is by 60-80 weight portions
Semen momordicae add water to cook 0.75-1.25h, add the Fructus Sophorae, the root of Dahurain angelica of 40-60 weight portions and the 60-70 of 125-145 weight portions
The kuh-seng of weight portion decocted and filtered after 1-2h, is concentrated filtrate and is obtained.
3. it is according to claim 1 treatment hemorrhoid external preparation, it is characterised in that the solution 1 be 90-110 weight
The borax of part is dissolved in the water of 110-130 weight portions, and the solution 2 is the chlorhexidine acetate and 70-90 weight portions of 10-30 weight portions
Borneol be dissolved in the ethanol of 70-90 weight portions.
4. the external preparation of the treatment hemorrhoid according to any one of claim 1-3, it is characterised in that the ointment bases choosing
At least one from oleaginous base, emulsion-type matrix and water-soluble base.
5. a kind of preparation method of the external preparation for treating hemorrhoid, it is characterised in that comprise the following steps：By 20-180 weight portions
Borax be dissolved in the water of 20-180 weight portions and obtain solution 1, by the chlorhexidine acetate of 5-40 weight portions and the ice of 20-120 weight portions
Piece is dissolved in the ethanol of 20-180 weight portions and obtains solution 2；
The semen momordicae of 20-120 weight portions is added water to cook into 0.75-1.25h, the Fructus Sophorae, the 20-120 of 50-250 weight portions is added
The root of Dahurain angelica of weight portion and the kuh-seng of 20-120 weight portions decocted and filtered after 1-2h, are collected filtrate and are obtained clear cream；
The clear cream, the solution 1 and the solution 2 are mixed with the ointment bases after fusing, the external application system is obtained
Agent.
6. it is according to claim 5 treatment hemorrhoid external preparation preparation method, it is characterised in that concentration filtrate press with
Under type is carried out：The dregs of a decoction after filtration are added water to cook into 0.5-1.5h, secondary liquid is filtrated to get again；By the filtrate and institute
State and concentrated after secondary liquid mixing.
7. the preparation method of the external preparation for the treatment of hemorrhoid according to claim 5, it is characterised in that decoct the Momordica cochinchiensis
The weight of the water of period of the day from 11 p.m. to 1 a.m addition is 3-5 times of the gross weight of the semen momordicae, the Fructus Sophorae, the root of Dahurain angelica and the kuh-seng.
8. the preparation method of the external preparation for the treatment of hemorrhoid according to claim 6, it is characterised in that decoct the dregs of a decoction
The weight of the water of Shi Tianjia is 3-10 times of the gross weight of the semen momordicae, the Fructus Sophorae, the root of Dahurain angelica and the kuh-seng.
9. it is according to claim 5 treatment hemorrhoid external preparation preparation method, it is characterised in that concentration filtrate be
Temperature is 50 DEG C -80 DEG C, and pressure is to be concentrated in vacuo to the filtrate relative to water under 0.02MPa -0.06MPa condition of negative pressure
Density is 1.0-1.6.
10. the preparation method of the external preparation for the treatment of hemorrhoid according to claim 5, it is characterised in that mixing is described clear
During the ointment bases after cream, the solution 1, the solution 2 and fusing, the temperature of the ointment bases is 50-90 DEG C.
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|---|---|---|---|
| CN201710164846.2A CN106619803B (en) | 2017-03-20 | 2017-03-20 | External preparation for treating hemorrhoids and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229651A (en) * | 1998-03-23 | 1999-09-29 | 周彬 | Haemorrhoids powder |
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2017
- 2017-03-20 CN CN201710164846.2A patent/CN106619803B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1229651A (en) * | 1998-03-23 | 1999-09-29 | 周彬 | Haemorrhoids powder |
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| CN106619803B (en) | 2020-05-26 |
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