CN106165778A - For preventing and treating chicken feed of chicken Mycoplasma synoviae infection and preparation method thereof - Google Patents
For preventing and treating chicken feed of chicken Mycoplasma synoviae infection and preparation method thereof Download PDFInfo
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- CN106165778A CN106165778A CN201610529094.0A CN201610529094A CN106165778A CN 106165778 A CN106165778 A CN 106165778A CN 201610529094 A CN201610529094 A CN 201610529094A CN 106165778 A CN106165778 A CN 106165778A
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Abstract
The invention discloses a kind of chicken feed for preventing and treating the infection of chicken Mycoplasma synoviae and preparation method thereof, wherein, feedstuff is made up of the raw material of following parts by weight: Semen Tritici aestivi 40 60 weight portion, dried pumpkin 15 25 weight portion, bean cake 11 20 weight portion, papaya powder 8 17 weight portion, beer yeast powder 69 weight portion, stone powder 37 weight portion, Sal 0.1 0.3 weight portion, olive oil 0.5 1 weight portion, soybean oil 0.1 0.6 weight portion, microelement pre-mix material 0.01 0.02 weight portion, vitamin premix 0.01 0.02 weight portion and feed additive 8 15 weight portion.The invention has the beneficial effects as follows: the raw material of feedstuff of the present invention is all natural product, chicken Mycoplasma synoviae can not only be effectively prevented to infect, moreover it is possible to improving chicken resistance against diseases, each raw material cooperates, common effect, has the advantages such as safety height, drug residue free, toxic and side effects.
Description
Technical field
The present invention relates to chicken feed, particularly to a kind of for preventing and treating chicken feed and the system thereof that chicken Mycoplasma synoviae infects
Preparation Method.
Background technology
The infection of chicken Mycoplasma synoviae is a kind of acute and chronic infectious disease of chicken and turkey, arthroncus, synovial capsule and stndon sheath
Inflammation symptom is obvious.This disease course of disease is long, and cage bird is difficult to be found, and produces often to poultry and causes the loss being difficult to make up, should
Disease is distributed in the whole world, and the sickness rate of this interior syndrome state had and increases trend in recent years, and some areas or season remain serious.
Naturally the incubation period being infected by contact with is generally 10~20d, can fall ill through the chickling of egg vertical infection in 1 week old.
The pathogenicity of different strains has larger difference, therefore clinically, some case shows as serious disorder of joint, and other is sick
Example then shows as serious respiratory symptom, also has the two to have both at the same time.Joint type case: initial infection, sick chicken spirit is still
Good, diet is normal;The course of disease is the longest, then lassitude, stays alone, and happiness is sleeping, often stays in hopper and tank limit, and appetite declines, and growth stops
Stagnant, to become thin, dehydration, cockscomb is pale, and cockscomb atrophy time serious, in aubergine.Classical symptom is tarsal joint and sole of the foot arthroncus, lame
OK, even deform;There is scleroma in chest Os Draconis seen from chronic cases, and then soften as saccus thoracicus swollen.Adult Chicken symptom is slight, only closes
Joint swelling, loses weight.Breathing pattern case: show as sneeze, cough, rhinorrhea, often inoculating live vaccine or suffering other
Green feces stress be arranged as respiratory symptom occurs after disconnected beak, cool winds.
At present, China controls this disease and is mainly by medicine control, and conventional medicine is mainly antibiotic, such as tylosin
Element, taimulin, doxycycline, erythromycin, oxytetracycline, kanamycin lincomycin, streptomycin, norfloxacin, enrofloxacin,
Fluorine Ben Nikao etc., spice, drinking-water.But antibiotic needs to change and uses, and can not will be present in the disease in chicken group
Substance is eradicated, and the long-term substantial amounts of abuse of antibiotic can produce serious negative effect.
Summary of the invention
The technical problem to be solved be how to provide a kind of safe treatment chicken Mycoplasma synoviae to infect, nontoxic
Side effect and prevention effect good for preventing and treating feedstuff and preparation method thereof that chicken Mycoplasma synoviae infects.
In order to realize foregoing invention purpose, the invention provides a kind of for preventing and treating raising of chicken Mycoplasma synoviae infection
Expecting, described feedstuff is made up of the raw material of following parts by weight: Semen Tritici aestivi 40-60 weight portion, dried pumpkin 15-25 weight portion, bean cake 11-
20 weight portions, papaya powder 8-17 weight portion, beer yeast powder 6-9 weight portion, stone powder 3-7 weight portion, Sal 0.1-0.3 weight
Part, olive oil 0.5-1 weight portion, soybean oil 0.1-0.6 weight portion, microelement pre-mix material 0.01-0.02 weight portion, vitamin
Premix material 0.01-0.02 weight portion and feed additive 8-15 weight portion.
Described feedstuff is made up of the raw material of following parts by weight: Semen Tritici aestivi 47-55 weight portion, dried pumpkin 17-23 weight portion, bean
Dregs of rice 13-18 weight portion, papaya powder 11-16 weight portion, beer yeast powder 6-8 weight portion, stone powder 4-6 weight portion, Sal 0.1-0.2
Weight portion, olive oil 0.7-1 weight portion, soybean oil 0.1-0.5 weight portion, microelement pre-mix material 0.01-0.02 weight portion, dimension
Raw element premix material 0.01-0.02 weight portion and feed additive 11-13 weight portion.
Described feedstuff is made up of the raw material of following parts by weight: Semen Tritici aestivi 51 weight portion, dried pumpkin 19 weight portion, bean cake 15 weight
Amount part, papaya powder 14 weight portion, beer yeast powder 7 weight portion, stone powder 5 weight portion, Sal 0.1 weight portion, olive oil 0.8 weight
Part, soybean oil 0.2 weight portion, microelement pre-mix material 0.01 weight portion, vitamin premix 0.01 weight portion and feedstuff add
Agent 12 weight portion.
Described feed additive includes following raw medicinal material: Ganoderma, saddle leaf, Herba leucadis zeylanicae, Herba Caraganae intermediae, Herba phlomidis, Rhizoma valerianae latifoliae, red
Head grass, Herba Pteridis Multifidae and Herba Lycopodii.
Described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 10-30 weight portion, saddle leaf 15-
24 weight portions, Herba leucadis zeylanicae 10-16 weight portion, Herba Caraganae intermediae 5-8 weight portion, Herba phlomidis 10-15 weight portion, Rhizoma valerianae latifoliae 13-21 weight portion, red
Head grass 11-19 weight portion, Herba Pteridis Multifidae 9-15 weight portion and Herba Lycopodii 9-15 weight portion.
Described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 15-27 weight portion, saddle leaf 18-
22 weight portions, Herba leucadis zeylanicae 11-14 weight portion, Herba Caraganae intermediae 5-7 weight portion, Herba phlomidis 10-13 weight portion, Rhizoma valerianae latifoliae 15-18 weight portion, red
Head grass 12-16 weight portion, Herba Pteridis Multifidae 11-13 weight portion and Herba Lycopodii 12-13 weight portion.
Described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 23 weight portion, saddle leaf 19 weight
Part, Herba leucadis zeylanicae 12 weight portion, Herba Caraganae intermediae 6 weight portion, Herba phlomidis 11 weight portion, Rhizoma valerianae latifoliae 17 weight portion, Herba Blumeae Lacerae 14 weight portion, phoenix tail
Grass 12 weight portions and Herba Lycopodii 12 weight portion.
Preferably, described feed additive also includes: Semen Cuscutae, Anotis wightiana (Wall.) Hook.F., Herba Polygoni japonici and herba ineritis gracilis;Described feedstuff adds
Agent is made up of the raw medicinal material of following parts by weight: Ganoderma 10-30 weight portion, saddle leaf 15-24 weight portion, Herba leucadis zeylanicae 10-16
Weight portion, Herba Caraganae intermediae 5-8 weight portion, Herba phlomidis 10-15 weight portion, Rhizoma valerianae latifoliae 13-21 weight portion, Herba Blumeae Lacerae 11-19 weight portion, phoenix tail
Grass 9-15 weight portion, Herba Lycopodii 9-15 weight portion, Semen Cuscutae 10-15 weight portion, Anotis wightiana (Wall.) Hook.F. 5-13 weight portion, Herba Polygoni japonici 7-16 weight
Amount part and herba ineritis gracilis 5-8 weight portion.
Described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 15-27 weight portion, saddle leaf 18-
22 weight portions, Herba leucadis zeylanicae 11-14 weight portion, Herba Caraganae intermediae 5-7 weight portion, Herba phlomidis 10-13 weight portion, Rhizoma valerianae latifoliae 15-18 weight portion, red
Head grass 12-16 weight portion, Herba Pteridis Multifidae 11-13 weight portion, Herba Lycopodii 12-13 weight portion, Semen Cuscutae 10-13 weight portion, Anotis wightiana (Wall.) Hook.F.
6-11 weight portion, Herba Polygoni japonici 8-14 weight portion and herba ineritis gracilis 5-7 weight portion.
Described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 23 weight portion, saddle leaf 19 weight
Part, Herba leucadis zeylanicae 12 weight portion, Herba Caraganae intermediae 6 weight portion, Herba phlomidis 11 weight portion, Rhizoma valerianae latifoliae 17 weight portion, Herba Blumeae Lacerae 14 weight portion, phoenix tail
Grass 12 weight portions, Herba Lycopodii 12 weight portion, Semen Cuscutae 11 weight portion, Anotis wightiana (Wall.) Hook.F. 8 weight portion, Herba Polygoni japonici 11 weight portion and herba ineritis gracilis
6 weight portions.
When described feed additive is powder, its preparation method is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains the first step powder and adds immersion 6 hours~12 hours in cold water, and with slow fire boiling, decocting time is 3
Hour~5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder quality
2~4 times;
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, and with slow fire boiling 2 hours~4 hours, filtration obtained
Obtaining the second filtrate, the quality of the water added is 2~4 times of the powder quality that second step obtains;
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry
Dry, it is ground into powder, granularity is 80~120 mesh;
5th step, in the powder that described 4th step obtains, adds starch, described starch percentage by weight in described powder
It is 15%~30%, obtains described powder.
When described feed additive is granule, its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, add relative to the determining alcohol of mixture 4~8 times be 85%~
The ethanol of 95%, is heated to boiling reflux 3~5 hours, filters, use percolation with per minute 1~2ml speed slowly percolation,
Collect percolate, when being evaporated to 50~60 DEG C subsequently under vacuum 0.06~0.09Mpa relative density be 1.04~
The mastic of 1.10, is spray-dried, the inlet temperature 160 of spray dryer~175 DEG C, leaving air temp 80~85 DEG C, pulverizes subsequently
Become powder, make dried cream powder;
Step 2: add in the dried cream powder obtained relative to dried cream powder quality 0.2~the cane sugar powder of 0.4 times and 0.1~0.2 times
Dextrin, make granule, in 40~50 DEG C be dried, it is thus achieved that granule.
In order to preferably realize foregoing invention purpose, present invention also offers a kind of for preventing and treating chicken Mycoplasma synoviae sense
The preparation method of the chicken feed of dye, described preparation method is:
Weighing Semen Tritici aestivi, dried pumpkin and bean cake according to ratio of weight and number, put into pulverizer and pulverize after mixing, grinding particle size is
30-40 mesh;
Mixture and papaya powder after pulverizing, beer yeast powder, stone powder, Sal, olive oil, soybean oil, microelement pre-mix material,
Vitamin premix and feed additive put into mixer mix homogeneously, and incorporation time is 3-6 minute;
Putting into granulator to pelletize, pelleting temperature is 75-85 DEG C.
The invention has the beneficial effects as follows: the raw material of feedstuff of the present invention is all natural product, can not only effectively prevent chicken sliding
Liquid rami capsulares pathogen infection, moreover it is possible to improving chicken resistance against diseases, each raw material cooperates, and jointly acts on, has safety high, without medicine
The advantages such as residual, toxic and side effects.
Detailed description of the invention
Embodiments provide a kind of for preventing and treating the feedstuff that chicken Mycoplasma synoviae infects, the feedstuff that feedstuff contains
Additive includes following raw medicinal material: Ganoderma, saddle leaf, Herba leucadis zeylanicae, Herba Caraganae intermediae, Herba phlomidis, Rhizoma valerianae latifoliae, Herba Blumeae Lacerae, Herba Pteridis Multifidae and stretch
Muscle grass;Preferably, also include: Semen Cuscutae, Anotis wightiana (Wall.) Hook.F., Herba Polygoni japonici and herba ineritis gracilis.
The characteristic of above-mentioned raw materials is as follows:
Ganoderma: sweet;Flat;Nontoxic.Return lung;The heart;Spleen;Kidney channel.Function cures mainly: replenishing QI and blood;Tranquilizing mind;Strengthening the spleen and stomach.Main asthenia;The heart
Throb with fear;Insomnia;Dizzy;Spiritlessness and weakness;Chronic cough is panted;Coronary heart disease;Silicosis;Tumor.
Saddle leaf: another name: Herba Lespedezae Cuneatae, butterfly wind, Radix Rumicis Japonici rattan, silk tree leaf.Source: pulse family bauhinia saddle leaf sheep
Bauhinia variegata Linn Bauhinia faberi Oliv., is used as medicine with root, sprout and leaf.Root is adopted the whole year, and sprout and leaf are adopted summer, dry.Root:
Sour, puckery, flat.Leaf, sprout: bitter, puckery are cool.Function cures mainly: root: antidiarrheal, calms the nerves, pain relieving, eliminating stagnation.For suffering from diarrhoea, function of nervous system
Disease, bones and muscles pain;Lymphoid tuberculosis is controlled in external.Leaf, sprout: solve noxious dampness, putrefaction-removing granulation-promoting.For pemphigus, stubborn dermatitis, skin is wet
Rash, carbuncle sore festers, burn and scald.
Herba leucadis zeylanicae: bitter, pungent, temperature.Function cures mainly: expelling wind and cold, preventing phlegm from forming and stopping coughing.Flu, headache, toothache, cough, throat
Inflammation, pertussis, bronchial asthma.
Herba Caraganae intermediae: another name horse collection bavin, Herba Damnacanthi.Source: medical material Ji Yuan: for the herb of leguminous plant Caragana intermedia.Sweet;
Temperature.Return liver;Kidney channel.Function cures mainly: nourishing YIN and supplementing blood, invigorates blood circulation.Main menoxenia.
Herba phlomidis: pungent, temperature.Function cures mainly: dispelling, collateral-activating, bone and muscle strengthening, detumescence.For catching a cold, rheumatic arthritis, lumbago,
Traumatic injury, furuncle toxic swelling.
Rhizoma valerianae latifoliae: hardship pungent, micro-, temperature.Function cures mainly: promoting digestion and invigorating the stomach, regulating QI to relieve pain, removing toxic substances of dispeling the wind.Stomachache abdominal distention, digestion is not
Good, infantile malnutrition, gastroenteritis, dysentery, rheumatalgia, soreness of the waist and knees.
Herba Blumeae Lacerae: another name: Hemerocallis citrina Baroni Scabrous Elephantfoot Herb.Source: Compositae Herba Blumeae Balsamiferae platymiscium is shown in the yellow Blumea lacera DC. of frost
Herb.Spring and summer is gathered, and clean chopping is dried, or fresh leaf.Hardship, cold.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flat
Fructus Persicae body is scorching, stomatitis, gingival abscess, mumps, infantile pneumonia;Ulcerative carbuncle toxic swelling, skin pruritus are controlled in external." Guangxi medicine
Plant register ": control wound and swell and ache." Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, antiinflammatory.Control infantile pneumonia, tonsillitis, parotitis, oral cavity
Inflammation, innominate toxic swelling, skin pruritus.
Herba Pteridis Multifidae: hardship light, micro-is cool.Function cures mainly: clearing away heat-damp and promoting diuresis, and detoxify dysentery relieving, cooling blood for hemostasis.For dysentery, gastrointestinal
Inflammation, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication;Traumatic hemorrhage, burn and scald are controlled in external
Wound.
Herba Lycopodii: bitter;Pungent;Temperature;Nontoxic;Flat.Return liver;Spleen;Kidney channel.Function cures mainly: expelling wind and cold;Dehumidifying detumescence;Relaxing muscles and tendons
Invigorate blood circulation;Cough-relieving;Removing toxic substances.Main anemofrigid-damp arthralgia;Joint aches;Skin numbness;Tetraparesis;Edema;Traumatic injury;Jaundice;Cough;
Skin infection;Herpes;Scald.
Semen Cuscutae: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down;
Externally treating leucoderma.
Anotis wightiana (Wall.) Hook.F.: sweet, sour is flat.Function cures mainly: stomach invigorating, dampness removing, and disappear infantile malnutrition.For infantile malnutrition, edema due to deficiency of the spleen, jaundice.
Herba Polygoni japonici: pungent, temperature.Function cures mainly: cold expelling is invigorated blood circulation, dysentery relieving.For the cold pain of waist knee joint, measles, bacillary dysentery.
Herba ineritis gracilis: bitter, is slightly cold.Function cures mainly: heat-clearing and toxic substances removing, pain relieving.For icterohepatitis, conjunctivitis, furuncle and phyma.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means
Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 feed additive 1
Embodiments provide a kind of for preventing and treating the feed additive that chicken Mycoplasma synoviae infects, by following weight portion
The raw medicinal material of number is made: Ganoderma 23 weight portion, saddle leaf 19 weight portion, Herba leucadis zeylanicae 12 weight portion, Herba Caraganae intermediae 6 weight portion, Herba phlomidis
11 weight portions, Rhizoma valerianae latifoliae 17 weight portion, Herba Blumeae Lacerae 14 weight portion, Herba Pteridis Multifidae 12 weight portion and Herba Lycopodii 12 weight portion;
Its preparation method is:
Step one: mixed in described ratio by described raw medicinal material, adds the ethanol that determining alcohol is 90% relative to 6 times of mixture,
It is heated to boiling reflux 4 hours, filters, use percolation with the speed slowly percolation of 1.5ml per minute, collect percolate, with
After when being evaporated to 55 DEG C under vacuum 0.07Mpa relative density be the mastic of 1.07, be spray-dried, spray dryer
Inlet temperature 170 DEG C, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: add the cane sugar powder relative to dried cream powder quality 0.3 times and the dextrin of 0.1 times in the dried cream powder obtained, system
Become granule, be dried in 45 DEG C, it is thus achieved that feed additive.
Embodiment 2 feed additive 2
Embodiments provide a kind of for preventing and treating the feed additive that chicken Mycoplasma synoviae infects, by following weight portion
The raw medicinal material of number is made: Ganoderma 23 weight portion, saddle leaf 19 weight portion, Herba leucadis zeylanicae 12 weight portion, Herba Caraganae intermediae 6 weight portion, Herba phlomidis
11 weight portions, Rhizoma valerianae latifoliae 17 weight portion, Herba Blumeae Lacerae 14 weight portion, Herba Pteridis Multifidae 12 weight portion, Herba Lycopodii 12 weight portion, Semen Cuscutae 11
Weight portion, Anotis wightiana (Wall.) Hook.F. 8 weight portion, Herba Polygoni japonici 11 weight portion and herba ineritis gracilis 6 weight portion;
Its preparation method is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains the first step powder and adds immersion 9 hours in cold water, and with slow fire boiling, decocting time is 4 hours, will
Decoction liquor filters, it is thus achieved that the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second
Filtrate, the quality of the water added is 3 times of the powder quality that second step obtains;
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry
Dry, it is ground into powder, granularity is 100 mesh;
5th step, in the powder that described 4th step obtains, adds starch, described starch percentage by weight in described powder
It is 20%, obtains feed additive.
Embodiment 3 feedstuff 1
Embodiments providing a kind of for preventing and treating the feedstuff that chicken Mycoplasma synoviae infects, feedstuff is by following parts by weight
Raw material make: Semen Tritici aestivi 51 weight portion, dried pumpkin 19 weight portion, bean cake 15 weight portion, papaya powder 14 weight portion, beer yeast powder
7 weight portions, stone powder 5 weight portion, Sal 0.1 weight portion, olive oil 0.8 weight portion, soybean oil 0.2 weight portion, trace element are pre-
Batch mixing 0.01 weight portion, vitamin premix 0.01 weight portion and feed additive 12 weight portion;Wherein, feed additive is real
Execute the feed additive 1 of example 1 preparation.
The preparation method of feedstuff is:
Weighing Semen Tritici aestivi, dried pumpkin and bean cake according to ratio of weight and number, put into pulverizer and pulverize after mixing, grinding particle size is 40
Mesh;
Mixture and papaya powder after pulverizing, beer yeast powder, stone powder, Sal, olive oil, soybean oil, microelement pre-mix material,
Vitamin premix and feed additive put into mixer mix homogeneously, and incorporation time is 5 minutes;
Putting into granulator to pelletize, pelleting temperature is 85 DEG C.
Embodiment 4 feedstuff 2
Embodiments provide a kind of for preventing and treating the feedstuff that chicken Mycoplasma synoviae infects, former by following parts by weight
Material is made: Semen Tritici aestivi 55 weight portion, dried pumpkin 23 weight portion, bean cake 13 weight portion, papaya powder 16 weight portion, beer yeast powder 8 weight
Amount part, stone powder 4 weight portion, Sal 0.1 weight portion, olive oil 1 weight portion, soybean oil 0.1 weight portion, microelement pre-mix material
0.01 weight portion, vitamin premix 0.01 weight portion and feed additive 13 weight portion;Wherein, feed additive is embodiment
The feed additive 2 of 2 preparations.
The preparation method of feedstuff is:
Weighing Semen Tritici aestivi, dried pumpkin and bean cake according to ratio of weight and number, put into pulverizer and pulverize after mixing, grinding particle size is 40
Mesh;
Mixture and papaya powder after pulverizing, beer yeast powder, stone powder, Sal, olive oil, soybean oil, microelement pre-mix material,
Vitamin premix and feed additive put into mixer mix homogeneously, and incorporation time is 3 minutes;
Putting into granulator to pelletize, pelleting temperature is 75 DEG C.
Toxicity test
By the feed additive of the embodiment of the present invention 1 to mice by 7.81,18.34 and 40.11g crude drugs/kg continuous use 12 weeks
After (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks, result shows: feed additive of the present invention to the hair of mice, OK
All having no significant effect for indexs such as, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not have
Being found difference change and histological indications shows, after medication 12 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing
Become.Illustrate that feed additive of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Application NIH mice 40, SPF level, male and female half and half, body weight 18~22g, carry out acute toxicity test.Mice is random
Be divided into two groups, often group 20, i.e. matched group and administration group, fasting 12 hours before experiment;By prepared by embodiments of the invention 2 raising
Feed additives 2 is dissolved in water, and (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(i.e. single
Dosage is 32.9 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours,
Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group,
After administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight are the most just increasing
Often.
Contrast test
Large-scale chicken farm, Linyi in the September, 2014, the laying hen about most of 10 week old occur cockscomb atrophy,
Turning white, peel off, like sleeping, drop-head is closed one's eyes, and slightly disorderly, the situation such as the green feces of row occurs feather, and the phenomenon that chicken is dead occurs,
Ill chicken group being isolated immediately, there is swelling in various degree in the concrete ill chicken periarticular of discovery of observing, the tightest with apotelus
Weight, there is the situation of joint deformity, and death chicken is cutd open inspection in serious chicken, is taken out by exudate at joint, stndon sheath swelling,
Visible heterophil and cellulose infiltration, good with the dyeing of Ji's nurse Sa, Gram’s staining is negative, and shows in stained preparation
For pleomorphism spheroid or club shape, observe form under an electron microscope and differ, have for circle, have in thread.Through examining
Break and infect for typical case's chicken Mycoplasma synoviae.Choose 500 ill chickens of typical case, be randomly divided into five experimental grouies, be respectively real
Execute the situation no difference of science of statistics such as example group 1-embodiment group 4 and matched group, each experimental group chicken average weight, the state of an illness, age in days, point
Do not use according to 9:100 part by weight be added with embodiment group 1 feed additive 1 conventional feed (embodiment group 1), according to
9:100 part by weight is added with the conventional feed (embodiment group 2) of the feed additive 2 of embodiment group 2, the raising of embodiment group 3
Material (embodiment group 3), the feedstuff (embodiment group 4) of embodiment group 4 and conventional feed (matched group) are fed according to normal feed mode
Supporting, wherein matched group uses and visits wonderful woods or Tiamulin spice 125 g ton, feeds 7-21 days continuously.Feed period observation record
Respectively organizing therapeutic effect, result is as shown in Table 1 and Table 2.Wherein, feeding in 21 days, the symptom such as arthroncus all disappears, spirit, food
It is intended to wait and recovers normal for recovery from illness;The symptoms such as arthroncus disappear substantially, and spirit, appetite etc. are recovered to be normally effective substantially;Joint
Still swelling, spirit, appetite the most do not improve, even death is invalid.
Table 1 each experimental group therapeutic effect synopsis (only)
Group | Sum | Recovery from illness | Effectively | Invalid | Effective percentage | Mortality rate |
Embodiment group 1 | 100 | 90 | 8 | 2 | 98% | 2% |
Embodiment group 2 | 100 | 92 | 7 | 1 | 99% | 1% |
Embodiment group 3 | 100 | 94 | 5 | 1 | 99% | 1% |
Embodiment group 4 | 100 | 95 | 5 | 0 | 100% | 0% |
Matched group | 100 | 68 | 17 | 15 | 85% | 6% |
Knowable to the data of table 1, compared with the ill chicken of conventional medication, use and add containing embodiment of the present invention 1-2 feedstuff
Adding the feedstuff of agent and the ill chicken of the forage feed of the embodiment of the present invention 3 and 4, cure rate significantly improves.
Table 2 each experimental group recovery from illness number of elements and treatment time synopsis (%)
Group | Sum | The 1-7 days | The 8-14 days | The 15-21 days |
Embodiment group 1 | 90 | 18(24.7%) | 58(66.7%) | 14(8.6%) |
Embodiment group 2 | 92 | 23(26.6%) | 63(67.0%) | 6(6.4%) |
Embodiment group 3 | 94 | 25(26.6%) | 64(68.1%) | 5(5.3%) |
Embodiment group 4 | 95 | 28(29.5%) | 64(67.4%) | 3(3.2%) |
Matched group | 68 | 9(13.2%) | 18(26.5%) | 41(60.3%) |
Knowable to the data of table 2, compared with the ill chicken of conventional medication, use and add containing embodiment of the present invention 1-2 feedstuff
Adding the feedstuff of agent and the ill chicken of the forage feed of the embodiment of the present invention 3 and 4, its treatment time substantially shortens, and the overwhelming majority is suffered from
Disease can be fully recovered within treating two weeks.
By contrast experiment, the feed additive of the embodiment of the present invention is superior to conventional medicament, i.e. the present invention implements
The feed additive of example can be good at treating chicken Mycoplasma synoviae to be infected, and has safety height, drug residue free, the secondary work of poison
With etc. advantage.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (8)
1. for preventing and treating the chicken feed that chicken Mycoplasma synoviae infects, it is characterised in that described feedstuff is by following parts by weight
Raw material is made: Semen Tritici aestivi 40-60 weight portion, dried pumpkin 15-25 weight portion, bean cake 11-20 weight portion, papaya powder 8-17 weight portion,
Beer yeast powder 6-9 weight portion, stone powder 3-7 weight portion, Sal 0.1-0.3 weight portion, olive oil 0.5-1 weight portion, soybean oil
0.1-0.6 weight portion, microelement pre-mix material 0.01-0.02 weight portion, vitamin premix 0.01-0.02 weight portion and feedstuff
Additive 8-15 weight portion.
The most according to claim 1 for prevent and treat chicken Mycoplasma synoviae infect chicken feed, it is characterised in that described in raise
Material be made up of the raw material of following parts by weight: Semen Tritici aestivi 47-55 weight portion, dried pumpkin 17-23 weight portion, bean cake 13-18 weight portion,
Papaya powder 11-16 weight portion, beer yeast powder 6-8 weight portion, stone powder 4-6 weight portion, Sal 0.1-0.2 weight portion, olive oil
0.7-1 weight portion, soybean oil 0.1-0.5 weight portion, microelement pre-mix material 0.01-0.02 weight portion, vitamin premix
0.01-0.02 weight portion and feed additive 11-13 weight portion.
The most according to claim 1 and 2 for preventing and treating the chicken feed that chicken Mycoplasma synoviae infects, it is characterised in that institute
State feedstuff to be made up of the raw material of following parts by weight: Semen Tritici aestivi 51 weight portion, dried pumpkin 19 weight portion, bean cake 15 weight portion, Fructus Chaenomelis
Powder 14 weight portion, beer yeast powder 7 weight portion, stone powder 5 weight portion, Sal 0.1 weight portion, olive oil 0.8 weight portion, soybean oil
0.2 weight portion, microelement pre-mix material 0.01 weight portion, vitamin premix 0.01 weight portion and feed additive 12 weight
Part.
4., according to the chicken feed for preventing and treating the infection of chicken Mycoplasma synoviae described in any one of claim 1-3, its feature exists
In, described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 10-30 weight portion, saddle leaf 15-24 weight
Part, Herba leucadis zeylanicae 10-16 weight portion, Herba Caraganae intermediae 5-8 weight portion, Herba phlomidis 10-15 weight portion, Rhizoma valerianae latifoliae 13-21 weight portion, Herba Blumeae Lacerae
11-19 weight portion, Herba Pteridis Multifidae 9-15 weight portion and Herba Lycopodii 9-15 weight portion.
5., according to the chicken feed for preventing and treating the infection of chicken Mycoplasma synoviae described in any one of claim 1-4, its feature exists
In, described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 15-27 weight portion, saddle leaf 18-22 weight
Part, Herba leucadis zeylanicae 11-14 weight portion, Herba Caraganae intermediae 5-7 weight portion, Herba phlomidis 10-13 weight portion, Rhizoma valerianae latifoliae 15-18 weight portion, Herba Blumeae Lacerae
12-16 weight portion, Herba Pteridis Multifidae 11-13 weight portion and Herba Lycopodii 12-13 weight portion.
6., according to the chicken feed for preventing and treating the infection of chicken Mycoplasma synoviae described in any one of claim 1-5, its feature exists
In, described feed additive is made up of the raw medicinal material of following parts by weight: Ganoderma 23 weight portion, saddle leaf 19 weight portion, honeybee
Nest grass 12 weight portions, Herba Caraganae intermediae 6 weight portion, Herba phlomidis 11 weight portion, Rhizoma valerianae latifoliae 17 weight portion, Herba Blumeae Lacerae 14 weight portion, Herba Pteridis Multifidae 12
Weight portion and Herba Lycopodii 12 weight portion.
7., according to the chicken feed for preventing and treating the infection of chicken Mycoplasma synoviae described in any one of claim 1-6, its feature exists
In, the preparation method of described feed additive is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, obtains the first step powder and adds immersion 6 hours~12 hours in cold water, and with slow fire boiling, decocting time is 3
Hour~5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder quality
2~4 times;
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, and with slow fire boiling 2 hours~4 hours, filtration obtained
Obtaining the second filtrate, the quality of the water added is 2~4 times of the powder quality that second step obtains;
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry
Dry, it is ground into powder, granularity is 80~120 mesh;
5th step, in the powder that described 4th step obtains, adds starch, described starch percentage by weight in described powder
It is 15%~30%, obtains described feed additive.
8. according to the preparation side for preventing and treating the chicken feed that chicken Mycoplasma synoviae infects described in any one of claim 1-7
Method, it is characterised in that the preparation method of described feedstuff is:
Weighing Semen Tritici aestivi, dried pumpkin and bean cake according to ratio of weight and number, put into pulverizer and pulverize after mixing, grinding particle size is
30-40 mesh;
Mixture and papaya powder after pulverizing, beer yeast powder, stone powder, Sal, olive oil, soybean oil, microelement pre-mix material,
Vitamin premix and feed additive put into mixer mix homogeneously, and incorporation time is 3-6 minute;
Putting into granulator to pelletize, pelleting temperature is 75-85 DEG C.
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CN105661083A (en) * | 2016-01-04 | 2016-06-15 | 成都健佳饲料有限公司 | Compound feed for chicks at brooding period and preparation method of compound feed |
CN105707508A (en) * | 2016-04-19 | 2016-06-29 | 烟台民望机电技术有限公司 | Chicken feed for preventing and treating chicken infectious rhinitis and preparation method thereof |
CN105707460A (en) * | 2016-04-19 | 2016-06-29 | 烟台民望机电技术有限公司 | Feed for preventing and treating chicken infectious rhinitis and preparation method thereof |
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CN1939465A (en) * | 2006-09-28 | 2007-04-04 | 天津生机集团有限公司 | Chinese-medicinal composition for treating fowl mycoplasmosis and mixed enteritis infection |
CN103372086A (en) * | 2012-04-23 | 2013-10-30 | 德州和膳生态农业有限公司 | Traditional Chinese medicine-based health care and epidemic prevention method for laying hen breeding |
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