CN106164675B - 检测人类骨膜蛋白的新型测定 - Google Patents

检测人类骨膜蛋白的新型测定 Download PDF

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Publication number
CN106164675B
CN106164675B CN201580007503.4A CN201580007503A CN106164675B CN 106164675 B CN106164675 B CN 106164675B CN 201580007503 A CN201580007503 A CN 201580007503A CN 106164675 B CN106164675 B CN 106164675B
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China
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periostin
antibody
serum
patient
sample
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Expired - Fee Related
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CN201580007503.4A
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Chinese (zh)
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CN106164675A (zh
Inventor
P.乔扈里
R.瓦基
M.梁
Y-W.李
K.斯特雷歇尔
K.拉纳德
E.格兰特
L.格林利斯
Y.姚
M.帕克
G.戴维斯
N.让布兰克
S.布洛菲
B.迪尔
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Abbott Laboratories
MedImmune LLC
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Abbott Laboratories
MedImmune LLC
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6884—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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CN201580007503.4A 2014-02-07 2015-02-05 检测人类骨膜蛋白的新型测定 Expired - Fee Related CN106164675B (zh)

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US201461936967P 2014-02-07 2014-02-07
US61/936967 2014-02-07
PCT/US2015/014671 WO2015120185A1 (en) 2014-02-07 2015-02-05 Novel assay to detect human periostin

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CN106164675A CN106164675A (zh) 2016-11-23
CN106164675B true CN106164675B (zh) 2019-04-23

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CN201580007504.9A Pending CN106170497A (zh) 2014-02-07 2015-02-05 检测人类骨膜蛋白的新型测定

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US (3) US10775388B2 (https=)
EP (2) EP3102951A1 (https=)
JP (3) JP2017506064A (https=)
KR (2) KR20160122756A (https=)
CN (2) CN106164675B (https=)
AU (2) AU2015214103A1 (https=)
BR (2) BR112016017901A2 (https=)
CA (2) CA2936285A1 (https=)
HK (2) HK1232238A1 (https=)
MX (2) MX2016009490A (https=)
RU (2) RU2016135418A (https=)
SG (2) SG11201606322XA (https=)
TW (1) TW201542589A (https=)
WO (2) WO2015120171A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018538249A (ja) 2015-11-04 2018-12-27 アストラゼネカ アクチボラグ 好酸球性疾患における好酸球標的化治療薬に対する臨床応答の予測変数としてのジペプチジルペプチダーゼ−４およびペリオスチン
JP7006599B2 (ja) * 2016-08-10 2022-02-10 株式会社シノテスト 試料に含まれるペリオスチンの測定試薬、ペリオスチン測定用前処理剤、ペリオスチン測定方法及びペリオスチン測定の感度の改善方法
JPWO2018194134A1 (ja) * 2017-04-20 2020-02-27 株式会社シノテスト 抗ペリオスチン抗体固定化担体、ペリオスチン測定試薬、及び抗ペリオスチン抗体固定化担体における抗体の安定化方法
CA3093422A1 (en) 2018-03-19 2019-09-26 Bioventures, Llc Periostin antibodies and methods of using the same
CN109879963A (zh) * 2019-03-15 2019-06-14 辽宁何氏医学院 一种抑制组织器官纤维化和新生血管形成的单克隆抗体及其制备方法和应用
MX2021012952A (es) 2019-04-26 2022-01-04 Univ Cornell Vacuna klebsiella y metodos de uso.
TW202342979A (zh) * 2021-12-28 2023-11-01 日商積水醫療股份有限公司 檢測方法及檢測試劑
CN115078734A (zh) * 2022-06-15 2022-09-20 苏州方达新药开发有限公司 一种细胞因子融合蛋白的检测分析方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
CN101189033B (zh) 2005-05-30 2012-03-28 株式会社器官再生工学 牙齿的制造方法、牙齿的集合体及组织的制造方法
RU2421464C2 (ru) 2005-10-21 2011-06-20 Новартис Аг Человеческие антитела к il-13 и их терапевтическое применение
CA2635849C (en) * 2005-12-28 2017-05-09 Asubio Pharma Co., Ltd. An antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
US8017119B2 (en) 2005-12-28 2011-09-13 Daiichi Sankyo Company, Ltd. Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
KR101560843B1 (ko) 2007-06-27 2015-10-15 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 페리오스틴의 Ｅｘｏｎ-17 부위에 의해 코드되는 펩티드에 대한 항체를 함유하는 암 치료제
EP2631302A3 (en) 2008-03-31 2014-01-08 Genentech, Inc. Compositions and methods for treating and diagnosing asthma
CN102065895A (zh) * 2008-04-11 2011-05-18 比奥根艾迪克Ma公司 抗-igf-1r抗体和其它化合物的治疗联合
FR2946349B1 (fr) * 2009-06-03 2013-10-04 Synarc Sas Sequences, anticorps, procedes et necessaires pour la detection et le dosage in vitro de la periostine, en vue du diagnostic du suivi ou du pronostic de pathologies ou de phenomenes biologiques impliquant la periostine
TWI732259B (zh) * 2010-12-16 2021-07-01 美商建南德克公司 關於th2抑制作用之診斷及治療
JP2014518626A (ja) 2011-05-18 2014-08-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 被験者が慢性腎疾患を有する、または発症するリスクがあるかどうかを決定するための方法
EP2710370A4 (en) 2011-05-18 2015-01-07 Medimmune Llc METHODS OF DIAGNOSING AND TREATING PULMONARY DISEASES OR DISORDERS
WO2013035799A1 (ja) 2011-09-06 2013-03-14 株式会社シノテスト ペリオスチンの特定領域に結合する抗体及びこれを用いたペリオスチンの測定方法
JP5797148B2 (ja) 2011-09-12 2015-10-21 富士フイルム株式会社 コレステリック液晶性混合物、フィルム、選択反射板、積層体および合わせガラス
WO2013038696A1 (ja) * 2011-09-15 2013-03-21 国立大学法人名古屋大学 胸膜中皮腫患者の早期発見のための分子マーカー及びその発現解析方法
WO2013126834A1 (en) * 2012-02-24 2013-08-29 Children's Hospital Medical Center Esophageal microrna expression profiles in eosinophilic esophagitis
EP2875049B1 (en) 2012-07-18 2018-12-26 Institut National de la Sante et de la Recherche Medicale (INSERM) Methods for preventing and treating chronic kidney disease (ckd)
US20160363591A1 (en) * 2014-01-27 2016-12-15 Medimmune, Llc Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Characterization of periostin isoform pattern in non-small cell lung cancer;Laura Morra et al.;《Lung Cancer》;20121231;第76卷(第2期);183-190 *

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