CN106146508A - 优化的联合用药及其治疗癌症和自身免疫疾病的用途 - Google Patents

优化的联合用药及其治疗癌症和自身免疫疾病的用途 Download PDF

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Publication number
CN106146508A
CN106146508A CN201510119944.5A CN201510119944A CN106146508A CN 106146508 A CN106146508 A CN 106146508A CN 201510119944 A CN201510119944 A CN 201510119944A CN 106146508 A CN106146508 A CN 106146508A
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China
Prior art keywords
compound
inhibitor
disease
pharmaceutical composition
tumor
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CN201510119944.5A
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English (en)
Chinese (zh)
Inventor
何伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
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ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
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Application filed by ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd filed Critical ZHEJIANG DAOMING PHARMACEUTICAL TECHNOLOGY Co Ltd
Priority to CN201510119944.5A priority Critical patent/CN106146508A/zh
Priority to PCT/CN2016/000149 priority patent/WO2016145935A1/zh
Priority to CN202010319886.1A priority patent/CN111349099A/zh
Priority to CN201680017009.0A priority patent/CN107406454B/zh
Priority to EA202092671A priority patent/EA202092671A1/ru
Priority to EP16764117.4A priority patent/EP3272752A4/en
Priority to EA201792066A priority patent/EA037058B1/ru
Priority to IL254435A priority patent/IL254435B2/en
Priority to KR1020227026364A priority patent/KR20220110872A/ko
Priority to CN202111303221.2A priority patent/CN114790209A/zh
Priority to JP2017549326A priority patent/JP7012534B2/ja
Priority to AU2016232923A priority patent/AU2016232923B2/en
Priority to MX2017011836A priority patent/MX2017011836A/es
Priority to CA3191171A priority patent/CA3191171A1/en
Priority to CA2980016A priority patent/CA2980016C/en
Priority to KR1020177025465A priority patent/KR102428387B1/ko
Priority to BR112017019790-1A priority patent/BR112017019790B1/pt
Priority to US15/183,340 priority patent/US9717745B2/en
Publication of CN106146508A publication Critical patent/CN106146508A/zh
Priority to AU2017286654A priority patent/AU2017286654A1/en
Priority to CA3027506A priority patent/CA3027506A1/en
Priority to US15/628,143 priority patent/US10098900B2/en
Priority to US16/123,167 priority patent/US10537587B2/en
Priority to US16/123,203 priority patent/US10596183B2/en
Priority to IL263641A priority patent/IL263641A/en
Priority to US16/790,197 priority patent/US11369620B2/en
Priority to AU2020277128A priority patent/AU2020277128B2/en
Priority to JP2021173052A priority patent/JP2022003103A/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/63Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P13/12Drugs for disorders of the urinary system of the kidneys
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201510119944.5A 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途 Pending CN106146508A (zh)

Priority Applications (27)

Application Number Priority Date Filing Date Title
CN201510119944.5A CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CA2980016A CA2980016C (en) 2015-03-19 2016-03-18 Optimized combination therapy and use thereof to treat cancer and autoimmune disease
CA3191171A CA3191171A1 (en) 2015-03-19 2016-03-18 Optimized combination therapy and use thereof to treat cancer and autoimmune disease
CN201680017009.0A CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
EA202092671A EA202092671A1 (ru) 2015-03-19 2016-03-18 Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания
KR1020177025465A KR102428387B1 (ko) 2015-03-19 2016-03-18 암 및 자가면역 질환을 치료하기 위한 최적화된 조합 요법 및 그의 용도
EA201792066A EA037058B1 (ru) 2015-03-19 2016-03-18 Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания
IL254435A IL254435B2 (en) 2015-03-19 2016-03-18 COMBINATION OF BTK INHIBITOR, mTOR KINASE INHIBITOR AND IMMUNOMODULATORY DRUG AND USE THEREFOR TO TREAT LYMPHOID MALIGNANCY
KR1020227026364A KR20220110872A (ko) 2015-03-19 2016-03-18 암 및 자가면역 질환을 치료하기 위한 최적화된 조합 요법 및 그의 용도
CN202111303221.2A CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202010319886.1A CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
AU2016232923A AU2016232923B2 (en) 2015-03-19 2016-03-18 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
MX2017011836A MX2017011836A (es) 2015-03-19 2016-03-18 Terapia de combinacion optimizada y uso de la misma para tratar cancer y enfermedad autoinmunitaria.
PCT/CN2016/000149 WO2016145935A1 (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
JP2017549326A JP7012534B2 (ja) 2015-03-19 2016-03-18 癌および自己免疫疾患を治療するための最適化された組合せ療法およびその使用
EP16764117.4A EP3272752A4 (en) 2015-03-19 2016-03-18 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
BR112017019790-1A BR112017019790B1 (pt) 2015-03-19 2016-03-18 Uso de um inibidor bruton tirosina quinase (btk)
US15/183,340 US9717745B2 (en) 2015-03-19 2016-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
AU2017286654A AU2017286654A1 (en) 2015-03-19 2017-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
CA3027506A CA3027506A1 (en) 2015-03-19 2017-06-15 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US15/628,143 US10098900B2 (en) 2015-03-19 2017-06-20 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US16/123,203 US10596183B2 (en) 2015-03-19 2018-09-06 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
US16/123,167 US10537587B2 (en) 2015-03-19 2018-09-06 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
IL263641A IL263641A (en) 2015-03-19 2018-12-11 Pharmaceutical preparations and their use for the treatment of cancer and autoimmune diseases
US16/790,197 US11369620B2 (en) 2015-03-19 2020-02-13 Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
AU2020277128A AU2020277128B2 (en) 2015-03-19 2020-11-24 Optimised combination therapy and use thereof to treat cancer and autoimmune disease
JP2021173052A JP2022003103A (ja) 2015-03-19 2021-10-22 癌および自己免疫疾患を治療するための最適化された組合せ療法およびその使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510119944.5A CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途

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CN106146508A true CN106146508A (zh) 2016-11-23

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Family Applications (4)

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CN201510119944.5A Pending CN106146508A (zh) 2015-03-19 2015-03-19 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202010319886.1A Pending CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202111303221.2A Pending CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN201680017009.0A Active CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途

Family Applications After (3)

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CN202010319886.1A Pending CN111349099A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN202111303221.2A Pending CN114790209A (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途
CN201680017009.0A Active CN107406454B (zh) 2015-03-19 2016-03-18 优化的联合用药及其治疗癌症和自身免疫疾病的用途

Country Status (11)

Country Link
EP (1) EP3272752A4 (enExample)
JP (2) JP7012534B2 (enExample)
KR (2) KR102428387B1 (enExample)
CN (4) CN106146508A (enExample)
AU (2) AU2016232923B2 (enExample)
BR (1) BR112017019790B1 (enExample)
CA (2) CA2980016C (enExample)
EA (2) EA037058B1 (enExample)
IL (1) IL254435B2 (enExample)
MX (1) MX2017011836A (enExample)
WO (1) WO2016145935A1 (enExample)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106831788A (zh) * 2017-01-22 2017-06-13 鲁南制药集团股份有限公司 伊布替尼精制方法
CN108992454A (zh) * 2018-06-20 2018-12-14 合肥医工医药有限公司 一种治疗皮肤炎症性疾病的复方药物组合物
CN109475566A (zh) * 2016-06-15 2019-03-15 浙江导明医药科技有限公司 药物组合物及其用于治疗癌症和自身免疫疾病的用途
CN110724143A (zh) * 2019-10-09 2020-01-24 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN110845500A (zh) * 2019-10-09 2020-02-28 清华大学 靶向btk降解化合物在治疗自身免疫系统疾病中的应用
CN112165945A (zh) * 2017-10-27 2021-01-01 浙江导明医药科技有限公司 治疗淋巴样恶性疾病之方法
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN116249533A (zh) * 2020-07-17 2023-06-09 轶诺(浙江)药业有限公司 一类肠道裂解型共药及其制备和用途
CN116615425A (zh) * 2020-09-17 2023-08-18 诺华股份有限公司 作为Sppl2a抑制剂的化合物和组合物
CN116898854A (zh) * 2022-04-12 2023-10-20 安徽中科拓苒药物科学研究有限公司 一种吡唑并嘧啶类化合物的新用途
WO2023213197A1 (zh) * 2022-05-06 2023-11-09 上海科技大学 mTOR抑制剂增强靶向蛋白降解药物功效的应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途
JP6782855B2 (ja) * 2016-11-15 2020-11-11 杭州和正医薬有限公司 選択性ブルトン型チロシンキナーゼ阻害剤及びその使用
MA50256A (fr) * 2017-09-15 2020-07-22 Aduro Biotech Inc Composés de pyrazolopyrimidinone et leurs utilisations
WO2019127008A1 (zh) * 2017-12-26 2019-07-04 清华大学 一种靶向降解btk的化合物及其应用
WO2019148150A1 (en) * 2018-01-29 2019-08-01 Dana-Farber Cancer Institute, Inc. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
GB201809746D0 (en) * 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations
CN109369654A (zh) * 2018-11-20 2019-02-22 山东大学 1,3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用
KR102819183B1 (ko) * 2019-03-29 2025-06-13 한미약품 주식회사 퓨로피리미딘 화합물의 산 부가염의 결정형
CA3153456A1 (en) 2019-10-02 2021-04-08 Stefanie Fluckiger-Mangual Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer
EP4171556A1 (en) * 2020-06-25 2023-05-03 Tolremo Therapeutics AG A combination of a cbp/p300 bromodomain inhibitor and an egfr inhibitor for use in treating egfr-mutant nsclc
KR20230028798A (ko) 2020-06-25 2023-03-02 톨레모 테라퓨틱스 아게 암 치료를 위한 CBP/p300 브로모도메인 억제제 및 KRAS 억제제의 조합물
CN114507236A (zh) * 2022-02-28 2022-05-17 山东中医药大学 mTOR蛋白降解靶向嵌合体及其制备方法和应用
CN116024346A (zh) * 2023-02-10 2023-04-28 复旦大学附属华山医院 SLCO1B1 rs2306283位点多态性在评价甲氨蝶呤所致骨髓抑制发生风险中的应用
CN117510494B (zh) * 2023-11-07 2024-04-19 桂林医学院附属医院 β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101674834A (zh) * 2007-03-28 2010-03-17 环状药物公司 布鲁顿氏酪氨酸激酶(Bruton’s tyrosine kinase)抑制剂
CN102159214A (zh) * 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
WO2014187319A1 (en) * 2013-05-21 2014-11-27 Jiangsu Medolution Ltd Substituted pyrazolopyrimidines as kinases inhibitors
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2529621B1 (en) * 2006-09-22 2016-10-05 Pharmacyclics LLC Inhibitors of bruton's tyrosine kinase
EP1921149A1 (en) * 2006-11-13 2008-05-14 AEterna Zentaris GmbH Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof
US7718662B1 (en) * 2009-10-12 2010-05-18 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
SI2710005T1 (sl) * 2011-05-17 2017-03-31 Principia Biopharma Inc. Zaviralci tirozinske kinaze
EP2731612A4 (en) * 2011-07-13 2015-04-08 Pharmacyclics Inc BRUTON TYROSINE KINASE HEMMER
CN104487441B (zh) * 2012-06-18 2018-06-01 普林斯匹亚生物制药公司 有用于治疗癌症和自身免疫性疾病的可逆的共价吡咯并嘧啶或吡唑并嘧啶
AU2013296627C9 (en) * 2012-07-30 2018-03-22 Concert Pharmaceuticals, Inc. Deuterated ibrutinib
WO2014022569A1 (en) * 2012-08-03 2014-02-06 Principia Biopharma Inc. Treatment of dry eye
KR102229478B1 (ko) * 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
WO2014143807A2 (en) * 2013-03-15 2014-09-18 Stromatt Scott Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
JP6389241B2 (ja) * 2013-04-17 2018-09-12 シグナル ファーマシューティカルズ,エルエルシー 癌を治療するためのTORキナーゼ阻害剤及びIMiD化合物を含む組合せ療法
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101674834A (zh) * 2007-03-28 2010-03-17 环状药物公司 布鲁顿氏酪氨酸激酶(Bruton’s tyrosine kinase)抑制剂
CN102159214A (zh) * 2008-07-16 2011-08-17 药品循环公司 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
WO2014187319A1 (en) * 2013-05-21 2014-11-27 Jiangsu Medolution Ltd Substituted pyrazolopyrimidines as kinases inhibitors
CN105017256A (zh) * 2014-04-29 2015-11-04 浙江导明医药科技有限公司 多氟化合物作为布鲁顿酪氨酸激酶抑制剂

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109475566A (zh) * 2016-06-15 2019-03-15 浙江导明医药科技有限公司 药物组合物及其用于治疗癌症和自身免疫疾病的用途
CN106831788B (zh) * 2017-01-22 2020-10-30 鲁南制药集团股份有限公司 伊布替尼精制方法
CN106831788A (zh) * 2017-01-22 2017-06-13 鲁南制药集团股份有限公司 伊布替尼精制方法
CN112165945A (zh) * 2017-10-27 2021-01-01 浙江导明医药科技有限公司 治疗淋巴样恶性疾病之方法
CN108992454A (zh) * 2018-06-20 2018-12-14 合肥医工医药有限公司 一种治疗皮肤炎症性疾病的复方药物组合物
CN108992454B (zh) * 2018-06-20 2020-06-02 合肥医工医药股份有限公司 一种治疗皮肤炎症性疾病的复方药物组合物
CN114522167A (zh) * 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
CN110845500A (zh) * 2019-10-09 2020-02-28 清华大学 靶向btk降解化合物在治疗自身免疫系统疾病中的应用
CN110724143B (zh) * 2019-10-09 2021-03-23 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN110724143A (zh) * 2019-10-09 2020-01-24 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN116249533A (zh) * 2020-07-17 2023-06-09 轶诺(浙江)药业有限公司 一类肠道裂解型共药及其制备和用途
CN116615425A (zh) * 2020-09-17 2023-08-18 诺华股份有限公司 作为Sppl2a抑制剂的化合物和组合物
CN116898854A (zh) * 2022-04-12 2023-10-20 安徽中科拓苒药物科学研究有限公司 一种吡唑并嘧啶类化合物的新用途
WO2023213197A1 (zh) * 2022-05-06 2023-11-09 上海科技大学 mTOR抑制剂增强靶向蛋白降解药物功效的应用

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