EA037058B1 - Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания - Google Patents
Оптимизированная комбинированная терапия и ее применение для лечения злокачественной опухоли и аутоиммунного заболевания Download PDFInfo
- Publication number
- EA037058B1 EA037058B1 EA201792066A EA201792066A EA037058B1 EA 037058 B1 EA037058 B1 EA 037058B1 EA 201792066 A EA201792066 A EA 201792066A EA 201792066 A EA201792066 A EA 201792066A EA 037058 B1 EA037058 B1 EA 037058B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- btk
- avg
- inhibitor
- pharmaceutically acceptable
- Prior art date
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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| CN106831788B (zh) * | 2017-01-22 | 2020-10-30 | 鲁南制药集团股份有限公司 | 伊布替尼精制方法 |
| JP2020533376A (ja) * | 2017-09-15 | 2020-11-19 | アドゥロ バイオテック，インク． | ピラゾロピリミジノン化合物およびその使用 |
| TW201922256A (zh) * | 2017-10-27 | 2019-06-16 | 中國大陸商浙江導明醫藥科技有限公司 | 治療淋巴樣惡性疾病之方法 |
| WO2019127008A1 (zh) * | 2017-12-26 | 2019-07-04 | 清华大学 | 一种靶向降解btk的化合物及其应用 |
| EP3746426A4 (en) | 2018-01-29 | 2021-12-29 | Dana Farber Cancer Institute, Inc. | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| GB201809746D0 (en) * | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| CN108992454B (zh) * | 2018-06-20 | 2020-06-02 | 合肥医工医药股份有限公司 | 一种治疗皮肤炎症性疾病的复方药物组合物 |
| CN110772521A (zh) * | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| CN109369654A (zh) * | 2018-11-20 | 2019-02-22 | 山东大学 | 1，3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用 |
| KR102819183B1 (ko) * | 2019-03-29 | 2025-06-13 | 한미약품 주식회사 | 퓨로피리미딘 화합물의 산 부가염의 결정형 |
| JP7395723B2 (ja) | 2019-10-02 | 2023-12-11 | トルレモ・セラピューティクス・アクチェンゲゼルシャフト | 複素環式誘導体、医薬組成物および癌の処置または寛解におけるそれらの使用 |
| CN110845500B (zh) * | 2019-10-09 | 2021-05-11 | 清华大学 | 靶向btk降解化合物在治疗自身免疫系统疾病中的应用 |
| CN110724143B (zh) * | 2019-10-09 | 2021-03-23 | 清华大学 | 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用 |
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| BR112022026186A2 (pt) | 2020-06-25 | 2023-01-17 | Tolremo Therapeutics Ag | Combinação de um inibidor de bromodomínio cbp/p300 e um inibidor de kras |
| CN113943312A (zh) * | 2020-07-17 | 2022-01-18 | 轶诺(浙江)药业有限公司 | 一类肠道裂解型共药及其制备和用途 |
| KR20230069947A (ko) * | 2020-09-17 | 2023-05-19 | 노파르티스 아게 | Sppl2a 억제제로서의 화합물 및 조성물 |
| CA3196886A1 (en) * | 2020-11-04 | 2022-05-12 | Yoram Devary | Polypeptides for use in the treatment and prevention of neurodegenerative diseases |
| CN114507236A (zh) * | 2022-02-28 | 2022-05-17 | 山东中医药大学 | mTOR蛋白降解靶向嵌合体及其制备方法和应用 |
| US20250241918A1 (en) * | 2022-04-12 | 2025-07-31 | Hefei Youyuan Pharmaceutical Co., Ltd. | Novel use of pyrazolopyrimidine compound |
| CN117045800A (zh) * | 2022-05-06 | 2023-11-14 | 上海科技大学 | mTOR抑制剂增强靶向蛋白降解药物功效的应用 |
| CN116024346A (zh) * | 2023-02-10 | 2023-04-28 | 复旦大学附属华山医院 | SLCO1B1 rs2306283位点多态性在评价甲氨蝶呤所致骨髓抑制发生风险中的应用 |
| CN117510494B (zh) * | 2023-11-07 | 2024-04-19 | 桂林医学院附属医院 | β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用 |
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| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
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Patent Citations (4)
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| US20120108612A1 (en) * | 2006-09-22 | 2012-05-03 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2008058944A1 (en) * | 2006-11-13 | 2008-05-22 | Aeterna Zentaris Gmbh | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| WO2014143807A2 (en) * | 2013-03-15 | 2014-09-18 | Stromatt Scott | Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders |
| CN105017256A (zh) * | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
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