CN106138680A - A kind of Chinese medicine composition with anti-oxidation function - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine composition with anti-oxidation function, described Chinese medicine composition is to be that crude drug is prepared from the Chinese medicine of following weight proportion: Fructus Jujubae 8-25 part, Radix Ginseng Rubra 4-12 part, Radix Ophiopogonis 8-16 part, Fructus Schisandrae Chinensis 3-8 part, Fructus Lycii 8-20 part.

Description

A kind of Chinese medicine composition with anti-oxidation function

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese prescription with anti-oxidation function and preparation side thereof Method and purposes.

Background technology

During human metabolism, many free radicals can be produced.Research finds, senile plaque atherosclerosis, the heart The sick generation such as angiopathy, cancer, peptic ulcer, Primary Nephrosis, diabetes, bronchial asthma, emphysema, Development has close relationship.Antioxidation refers to the abbreviation of resisting oxidation free radical, English Anti-Oxidant.More and more Research display antioxidation is pre-anti-aging important step, because cell and tissue breakdown can be affected by free radical or oxidant Metabolic function, and different health problems can be caused.If able to eliminate too much oxyradical, for many free radicals Cause and aging-related disease can prevent.

The traditional Chinese medical science is thought, gas, blood, body fluid are the base substances constituting human body, is also the basic thing maintaining human life activity Matter, is the product of the histoorgan physiological activity such as viscera, meridians, is also these histoorgans things of carrying out physiological activity Matter basis.Yang-energy, cloudy blood, body fluid metaplasia continuously are also transported to body surface organ, skin care, muscle of supplementing nutrition, profit Pool hair, resists the invasion and attack of exopathogen, thus shows as in vigorous health, fleshiness, skin exquisiteness high resilience, hair light Bright, mesh has god.

The invention provides a kind of Chinese prescription health food, this health food selects can be used for the vegetable raw material of health food The raw material of integration of edible and medicinal herbs in list, according to the dialectical compatibility of principle of " QI invigorating, enrich blood, promote the production of body fluid ", uses in the advanced modern times Medicine technology of preparing production and processing, makes and is easy to the Chinese medicine preparation that patient directly takes.Have that production technology is simple, toxic and side effects Little, the advantages such as medicine source is extensive, treating both the principal and secondary aspects of a disease, this Chinese prescription is made up of Fructus Jujubae, Radix Ginseng Rubra, Radix Ophiopogonis, Fructus Schisandrae Chinensis and Fructus Lycii.

Modern pharmacological research shows:

Fructus Jujubae has can the effect of benefiting qi and nourishing blood:

Fructus Jujubae has invigorating the spleen and replenishing QI, effect of nourishing blood to tranquillize the mind.Homovitamin content in Fructus Jujubae, has sound to human capillary vessel Effect.With Fructus Jujubae 20 pieces, 1, egg, 30 grams of brown sugar, water stewes clothes, every day 1 time, it is adaptable to puerperal takes good care of, and has Effect of vigorate qi and replenish the blood.

Fructus Jujubae has can be with the effect of hypnotic:

Fructus Jujubae, have spleen reinforcing, nourish blood, sedative action.Add decocting juice with Fructus Jujubae after supper to take；Or cook congee with Bulbus Lilii； Eat soup just before going to bed and eat Fructus Jujubae, can accelerate to fall asleep.With fresh date 1000 grams, clean enucleation takes meat and mashes, and adds suitable quantity of water literary composition Fire is decocted, and filters extracting juice, is mixed into 500 grams of Mel, mixes well and take into Fructus Jujubae cream on fire, bottle standby.Each serving 15 milliliters, Every day 2 times, take continuously, insomnia can be prevented and treated.

Additionally Fructus Jujubae also has the effects such as supplement calcium, preventing and treating seminal emission, anti-diarrhea.

Fructus Jujubae has an effect of beauty treatment:

Fructus Jujubae Glycerin, benefit face beauty treatment among the people has " solar eclipse three Fructus Jujubae, at the age of one hundred years old bear one's age well ", " skin to be made is good, in medicated porridge With Fructus Jujubae " say.Taking Fructus Jujubae 50 grams, Semen oryzae sativae 100 grams, with being cooked into medicated porridge, warm food clothes, have greatly beauty treatment skin sooner or later Benefit.Tracing it to its cause is that in Fructus Jujubae, substantial amounts of vitamin B can promote that subcutaneous blood circulates, and makes skin and hair smooth, face Wrinkle is smooth, and skin is more vigorous and more graceful.

Fructus Jujubae has an effect preventing from shaving one's head:

Fructus Jujubae has the function of strengthening the spleen and nourishing the stomach." spleen the most then skin is hard ", skin is radiant, and hair has then had part of taking shelter, institute It is possible to prevent falling out with the often nutritious Fructus Jujubae of food, and as black as jet hair can be grown.

Fructus Jujubae has an effect of stomach invigorating supplementing the brain:

The traditional Chinese medical science commonly uses Fructus Jujubae nourishing stomach and spleen.As met in prescription that the efficacy of a drug is more violent or during irritant medicine, Chang Peiyong Fructus Jujubae, With protecting the spleen and stomach, containing saccharide, protein, fat, organic acid in Fructus Jujubae, brain there is benefiting action.With Fructus Jujubae and face Powder makes Fructus Jujubae cake, can nourishing the stomach supplementing the brain.

Fructus Jujubae is reduced the effect of senile plaque:

Vitamin C contained in Fructus Jujubae is the reproducibility antioxidant that a kind of activity is the strongest, participates in internal physiology oxygen also Former process, prevents the chronicest precipitation of melanin, can efficiently reduce the generation of pigment senile plaque.

Fructus Jujubae has an effect of hepatoprotective:

Saccharide contained by Fructus Jujubae, fat, protein are liver-protective nutrients.It can promote liver synthetic proteins, increases Increase serum Lactoferrin and albumin content, adjust albumin and globulin, has prevention transfusion reaction, reduces serum paddy third Transaminase levels etc. act on.With Fructus Jujubae 50 grams, 90 grams of rice, being boiled into thick porridge and eat it, hepatitis is supported spleen hepatoprotective to be had greatly Benifit.With Fructus Jujubae, Semen arachidis hypogaeae, each 30 to 50 grams of crystal sugar, first boil Semen arachidis hypogaeae, then boil soup, the most just before going to bed with Fructus Jujubae and crystal sugar Take, within 30 days, be a course for the treatment of, acute, chronic hepatitis and liver cirrhosis are had certain curative effect.

Tradition application

1, to control taste raw for Fructus Jujubae, and diet reduces, and long has loose bowels, aqueous-grainy diarrhea: the Rhizoma Atractylodis Macrocephalae four liang, Rhizoma Zingiberis two liang.In chicken Gold two liang, ripe jujube pulp half jin.Adding medicine to four tastes, the Rhizoma Atractylodis Macrocephalae, Endothelium Corneum Gigeriae Galli are all with survivor, and every taste each rolls carefully, it is ripe to roast, then will do Rhizoma Zingiberis Recens is rolled carefully, republicanism jujube pulp, with smashing such as mud, makees little cake, charcoal fire is processed dry, time hollow, work as dessert, chew carefully pharynx.(" doctor Learn ginseng west record in inner feelings " strengthening the spleen cake)

2, Fructus Jujubae QI invigorating: great Nan Fructus Jujubae ten pieces, steams soft enucleation, joins Radix Ginseng one money, cloth bag, steams rotten in hiding pot for cooking rice, smashes and even is Ball, as pellet is big, harvests and store and uses it.(" garden record of waking up " Fructus Jujubae ginseng ball)

3, non-essential thrombopenia controlled by Fructus Jujubae: Fructus Jujubae, eats every day three times, each 10, all disappear to purpura for Only.Typically everyone about needs Fructus Jujubae one to two jin.(" Shanghai Chinese " (4): 22,1962)

4, woman hysteria controlled by Fructus Jujubae, and susceptible to sorrow is hindered, and is intended to cry, and frequent yawning is stretched: ten pieces of Fructus Jujubae, three liang of Radix Glycyrrhizae, Semen Tritici aestivi one liter.On Three tastes, with six liters of water, boil and take three liters, temperature point three clothes.(" Medical Treasures of the Golden Chamber " GANMAI DAZAO TANG)

5, Fructus Jujubae is controlled and is coughed: 120 pieces of Semen Armeniacae Amarum (peeling point, endure), fermented soya beans, salted or other wise 100 pieces (endures order dry), dry Fructus Jujubae 40 pieces (enucleation). Upper three taste platforms smash such as mud, ball such as almond, containing pharynx order to the greatest extent.Day seven, octave, to the greatest extent, more make.(broad-mouthed receptacle for holding liquid numerous " must efficacious prescriptions ")

6, asthenia unhappiness insomnia controlled by Fructus Jujubae: 20 pieces of Fructus Jujubae, Bulbus Allii Fistulosi seven stem.Upper two tastes, with three liters of water, boil one liter, Remove dregs's decoction being taken at a draught.(" prescriptions worth thousand gold ")

7, Fructus Jujubae is controlled the most anxious the most pained: Fructus Mume one, Fructus Jujubae two, seven, Semen Armeniacae Amarum.Smashing at one, men's wine, lady's vinegar send down. (" sea side ")

8, Fructus Jujubae is controlled regurgitation and is told food: one piece of Fructus Jujubae (enucleation), Chinese blister beetle of class one piece (decaptitate wing) is fed heat in entering, removed Cantharis, hollow food It, under plain soup.(" detailed outline ")

9, Fructus Jujubae is controlled apoplexy void in terror and is throbbed with fear, and extremity are heavy: seven pieces of Fructus Jujubae (enucleation), and blue or green fine strain of millet Semen setariae two closes.Upper two tastes are with water Three and half, first boil Fructus Jujubae and take one and half, go dregs, throw rice and cook congee food.(" Shengji Zonglu " tonification date porridge)

10, Fructus Jujubae control lung cellulitis spit blood and absurd row: Fructus Jujubae (with core charred medicinal herb with its property retained), Mass Galla chinesis et camelliae Fermentata (forging) each decile.For smalls, often take Two money, under rice water is adjusted.(" three categories of etiologic factors side " two ash dissipates)

Modern pharmacological research shows, Radix Ginseng Rubra has the effect that

1. Radix Ginseng Rubra has excitation to central nervous system, and has inhibitory action on the contrary time a large amount of.The senior god of animal can be strengthened Through movable excitement and process of inhibition.And the energy enhancing body adaptation ability to all nonspecific stimulations, feeling of fatigue can be reduced (root of Radix Ginseng Rubra, stem, leaf all can extend the persistent period that white mice is swum).

2. Radix Ginseng Rubra has directly effect to cardiac muscle and blood vessel, typically excited when low dose, suppression time heavy dose of.10% Radix Ginseng Rubra leaching Liquid 1 milliliter/kilogram gives cat (or rabbit) gavage, has some improvement amyocardia.Certain degree is had during rewarming Recovery.Also there are antianaphylaxis shock and the effect of heart tonifying.Rat myocardial cell film ATPase activity is had and presses down by Radix Ginseng Rubra Make and use.

3. the reinforcement body resistance to harmful factor:

(1) the plasmodial chicken of infection can be made to avoid acute death, and the body weight of chicken is also gradually increased.

(2) can Inhibition test animal exothermic reaction caused by injection milk or vaccine.

(3) human body can be strengthened and adapt to the ability of temperature Change.

(4) Canis familiaris L. massive blood loss or suffocate and when being in critically ill state, injection Radix Ginseng Rubra preparation immediately, can make to be down to the lowest water The firm rise of flat blood pressure.

(5) time-to-live of the mice by Trypanosoma cruzi infection can be extended.

(6) systemic inflammatory response injected Oleum Terebinthinae or cause due to rabbit ear shell cold injury can be suppressed.

(7) healing of some experimental injury is promoted.

(8) there is the effect of vitamin antagonist B1, B2 deficiency disease.

(9) Healing of rabbit experiment corneal ulcer can be accelerated.

(10) some poisonous substance (benzene, tetraethyl-lead, the three cresol phosphoric acid etc.) effect to body can be weakened.

4. the hyperglycemia animal pair caused because of epinephrine has the hypoglycemic effect of fall；Disease is improved to diabetics decapacitation is conscious Outside shape, the slightest hypoglycemic activity, and have synergism with islets of langerhans.

5. can promote the gonad function of animal, white mice eats Radix Ginseng Rubra in a small amount, can produce act tail phenomenon.

6. at suitable dosage, rabbit also can be put on weight, make plasma albumin increase with the ratio of globulin.

7. stimulate hemopoietic organ, have the effect improving anemia.

8. long-term taking is in a small amount, can make the reticuloendothelial system can be hyperfunction；Dosage is excessive, then in adverse effect.

Modern pharmacological research shows, Radix Ophiopogonis has the effect that

Impact on central nervous system

After Radix Ophiopogonis, total amino acids 0.5ml/10g lumbar injection awarded mice 30 minutes, lumbar injection pentobarbital sodium 30mg/kg, Observe righting reflex loss number of animals.Result total amino acids Radix Ophiopogonis has the most collaborative central depressant effect (P < 0.05), And the pentobarbital sodium effect of subthreshold hypnotic dosage is had no significant effect by ophiopogon root total saponin and total sugar.15% Radix Ophiopogonis must preparation 10ml/kg gavage can suppress to inject the heating (P < 0.01) of the rabbit of Oleum Terebinthinae 2.0ml/kg, but after heating, medication is then without pressing down Make and use.Radix Ophiopogonis, decoct had sedation, also can strengthen the sedation of chlorpromazine, strengthened the syngignoscism of pentobarbital sodium, The excitation of antagonism caffeine, can postpone the tic that dimefline causes, tonic convulsion and the dead time occurred, but not Animal can be made to avoid death.

Impact on cardiovascular system

Impact in vitro bufonid toad toad cardiac function: prove with Yagi spark gap-Hartung method Isolated Toad Heart perfusion；Radix Ophiopogonis is total It is the strongest that Saponin I (crude extract) strengthens myocardial contraction effect, and Total saponin II (purer thing) effect is not as good as Total saponin I, Typically with kinemic increase while myocardial contraction strengthens.Heavy dose of Total saponin I, II and total sugar are to heart All produce suppression, myocardial contraction can be made to weaken, cardiac output reduces, atrioventricular block, even stop Fu.Total saponin I, II, heart rate is the most slightly slowed down or constant by total sugar, total amino acids, all has no significant effect.

Impact on isolated guinea pig heart myocardial contraction amplitude: show with Langendorff method guinea pig isolated heart perfusion, wheat Winter Total saponin and total amino acids low dose all can make myocardial contraction strengthen, and coronary flow increases, and heavy dose then suppresses cardiac muscle, Reduce coronary flow, but both on heart rate without impact.

Antiarrhythmic effect and electrophysiological characteristics thereof: ophiopogon root total saponin 10mg/kg intravenous injection can effectively prevent or resist By CHCL3-Adr, the arrhythmia that BaCl2, Aco are induced, and make the ventricular rhythm after ligation dog coronary artery 24h lose Often incidence rate is down to 57 ± 7% by 87 ± 8.It is single-phase that electro physiology experiment shows that ophiopogon root total saponin 15mg/kg can obviously reduce rabbit The Vmax of action potential, shortens its APD10, APD50；Ophiopogon root total saponin 50 μ g/ml also can make guinea pig papillary muscle cell The APA of transmembrane action potential, Vmax substantially reduce, and APD10, APD50 substantially shorten；ERP/APD significantly increases simultaneously. All there is improvement result Radix Ophiopogonis to barium chloride, aconitine, the arrhythmia caused by epinephrine, pituitrin etc..Use sulphuric acid Magnesium 2.5g, Radix Ophiopogonis, 20g was diluted in 500ml G/NS angular vein instillation Experiment on therapy Cor Canitis muscle infarction, used Medicine 6h, 24h premature beat occurrence number is compared with matched group, and result shows that Radix Ophiopogonis, the rhythm of the heart after heart infarction was lost by contract low dose magnesium sulfate Often there is certain preventive effect.

On the impact of cyclic nucleotide metabolism during Myocardial Infarction: ligature branch of coronary artery after anaesthetizing with new zealand rabbit, cause Acute experiment myocardial inyaretion, through ear vein injection Dwarf lilyturf tuber injection 15ml (suitable crude drug 15g).Then with matched group one Rise the most at once, postoperative 15,30,60 minutes, direct cardiac puncture is taken a blood sample, and measures plasma cAMP and cGMP.Knot The most postoperative 15 minutes, matched group cAMP, cGMP continued to raise, group Radix Ophiopogonis (P < 0.05) on a declining curve, postoperative 30 points Clock group Radix Ophiopogonis is still below matched group (P < 0.02), within postoperative 60 minutes, recovers to preoperative level.Plasma cAMP/cGMP ratio becomes Change: preoperative two groups there was no significant difference, and two groups of ratios of immediate postoperative all decline；Matched group 15,30 minutes after surgery, continues Continuous decline is respectively 4.6 ± 1.61；4.57±2.01；And group Radix Ophiopogonis is close to preoperative level, respectively 6.46 ± 2.12 With 6.48 ± 2.39 (P value all < 0.05), postoperative 60 minutes, Radix Ophiopogonis, group still maintained preoperative level, and matched group has rising to become Gesture, two groups without significant difference.After acute myocardial infarction, plasma cAMP, cGMP content are apparently higher than normally.It is probably one Stress, owing to a large amount of myocardium cell necrosis dissolve, discharges cAMP and cGMP, makes plasma levels increase, reaction The degree of myocardial damage.During due to myocardial ischemia, cGMP increases relatively cAMP and becomes apparent from, so cAMP/cGMP ratio after heart infarction Value is decreased obviously.After may making infraction Radix Ophiopogonis, myocardial alimentary blood flow increases, and the myocardial cell of hypoxic-ischemic comparatively fast obtains reparation With protection, cause the release of cardiac muscle cGMP and cAMP to reduce, thus reduce the content in blood plasma, and make both ratios recover Balance.

Impact on animal immune activity

Impact on mice oxygen deficit tolerance ability: take 18-20g, ICR mice 30, respectively lumbar injection Radix Ophiopogonis polysaccharide, Radix Ginseng total saponins (20mg/kg), comparison normal saline, in 30 minutes rearmounted airtight wide mouthed bottles filling sodica calx, Record mouse diing time.The mouse survival time of result Radix Ophiopogonis polysaccharide group compares significantly prolongation (P < 0.01) with matched group.

Impact on immune organ weight: take ICR mice lumbar injection Radix Ophiopogonis polysaccharide, Radix Ginseng total saponins (dosage respectively 10mg/kg), comparison normal saline, successive administration is sacrificed by exsanguination animal after 7 days, weighs and thymus, spleen weight Amount, calculates thymus index and spleen index.Result Radix Ophiopogonis polysaccharide can dramatically increase the spleen weight (P < 0.01) of mice in pole, and Thymus is had no significant effect.

Impact on mice carbon clearance effect: take ICR mice, respectively lumbar injection Radix Ophiopogonis polysaccharide, Radix Ginseng total saponins (10mg/kg) and normal saline, successive administration 7 days, after last is administered, tail vein awards the Chinese carbon element ink of dilution 3 times Water 0.1ml/10g, calculates respectively and cleans up index.Result Radix Ophiopogonis polysaccharide group can be obviously enhanced the carbon clearance effect of mice (P < 0.01=.

The impact that the murine interleukin number caused declines is irradiated: Radix Ophiopogonis polysaccharide 10mg/kg is to little on by cyclophosphamide and 60Cor Leukopenia caused by Mus lumbar injection 0.4ml cyclophosphamide (5mg/ml) has extremely significantly antagonism (P < 0.01). The continuous lumbar injection of same dose of Radix Ophiopogonis polysaccharide 8 days, after within the 8th day, being administered, mice is placed on away from irradiation source (60Cor) by lh Being irradiated at 60cm, accumulated dose 20.64c/kg, continue to be administered 3 days after irradiation, after irradiation the 7th day, eye socket took blood, Calculate white blood cell count.Result Radix Ophiopogonis polysaccharide can significantly resist the leukocyte caused by 60Cor roentgenization and decline (P < 0.01=.

Radix Ophiopogonis polysaccharide is formed with, to hemolysin in mice serum, the effect of being obviously promoted, and rabbit erythrocyte is had agglutinin Effect.

Radix Ophiopogonis decocting liquid intraperitoneal injection of mice, dosage suitable 12.5g crude drug/kg, mouse spleen weight can be dramatically increased in pole； Strengthen mice carbon clearance effect；Extremely significantly resist the leukopenia etc. caused by cyclophosphamide to act on.

On humoral immunization and the impact of cellular immunization: with BALB/C children Mus, be paired into test group and matched group, raise January After, every Mus injection ovine cells (SRBC) 4.O hundred million (0.2ml), periodically take blood after injection, measure antibody, calculate HC50. Result shows with having promotion antibody tormation Radix Ophiopogonis and delay antibody to disappear (P < 0.05).Two groups of BALB/C mice with pairing Splenocyte suspension, 2 parts add PHA60 μ g/ml, and 1 part to be not added with fracturing former.After cultivating 72h, mix with 3H thymidine Measuring lymphocyte transformation stimulation index after entering on scintiloscope, result shows, fibrous root of Radix Ophiopogonis extract is improved cellular immunization Effect.

Impact on Immunological Functions In Mice Bearing Transplantable: NIH pure lines must be inoculated the white of S180 and EAC cancerous cell by aqueous solution by Radix Ophiopogonis Cell and T cell are all significantly improved (P < 0.01 or P < 0.05).Tu% content can be made to increase T cell subgroup, Tr% Content declines, and T u/Tr value is all high than matched group.

Other effect

Mice adds root hair Radix Ophiopogonis in feedstuff can reduce internal hydroxyproline.To monoamine oxidase, MAO in male mice brain (MAO-B) suppression ratio is 38.6%.In male mice liver, SOD activity improves 45.5%.Life span of drosophila melanogaster test also shows Radix Ophiopogonis Root hair feedstuff has and significantly extends life span of drosophila melanogaster, and prompting has slow down aging trend.Swimming test shows Saponin contained by Radix Ophiopogonis, many Sugar, aminoacid etc. have obvious antifatigue effect.

Modern pharmacological research shows, Fructus Schisandrae Chinensis has the effect that

1. pair central nervous system's effect

Have Fructus Schisandrae Chinensis obvious sedation, Fructus Schisandrae Chinensis extrat and alcohol first can reduce mice autonomic activities, still have analgesia to make By, myorelaxant effects.

2. hepatoprotective effect

Chemical toxicant is drawn by Chinese Magnoliavine Fruit alcohol extract and deoxyschizandrin, B prime, C prime, alcohol first, alcohol second, ester first, ester the second grade The animal liver cell damage risen has obvious protective function.

3. pair Cardiovascular System

Fructus Schisandrae Chinensis has vasodilative effect.Schizandrin, schisandrin C, deoxyschisandrin etc. move in vitro Canis familiaris L. mesentery Arteries and veins shrinks all inhibitory action, can increase arteries and veins Mus isolated heart and anesthesia Canis familiaris L. coronary flow.

4. delaying senility function

" herbal classic " is recorded, Fructus Schisandrae Chinensis " main QI invigorating, tonifying for the deficiency, reinforcing YIN-essence, benefit man's essence ".Schisandrin B, Fructus Schisandrae Chinensis Phenol is respectively provided with antioxidation, can remove free radical, suppression lipid peroxide formation.Additionally, Fructus Schisandrae Chinensis can reduce serum gallbladder Sterin, increases protein content in brain regulating liver-QI, all shows have anti-aging effects.

5. pair respiratory system effect

Fructus Schisandrae Chinensis can " receipts lung qi ", " relieving coughing Dingchuan ".It is thin that Fructus Schisandrae Chinensis can strengthen murine chronic bronchitis bronchiolar epithelium Born of the same parents' function.

6. pair metabolism and the effect of immunologic function

Fructus Schisandrae Chinensis can promote the synthesis of hepatic glycogen, makes carbohydrate metabolism strengthen, and can increase again the synthesis of Hepatocyte matter.

7. antiulcer action Fructus Schisandrae Chinensis is to rat oral gavage, can suppress the generation of stress ulcer, makes ulcer index reduce, and Gastric secretion can be suppressed.

8. the effect calmed the nerves

Fructus Schisandrae Chinensis has good sedative action, adheres to drinking the Fructus Schisandrae Chinensis water bubbled open, can good relieving insomnia symptom.

Modern pharmacological research shows, Fructus Lycii has the effect that

One immunomodulating

Fructus Lycii is rich in lycium barbarum polysaccharide, and lycium barbarum polysaccharide is a kind of water soluble polysaccharide, by arabinose, glucose, galactose, Mannose, xylose, these 6 kinds of monosaccharide components compositions of rhamnose, have physiologically active, it is possible to enhancing non-specific immunity function, Improve resistance against diseases, suppression tumor growth and cell mutation.

Two defying age

Immunosenescence is closely related with apoptosis.Lycium barbarum polysaccharide (LBP), can significantly improve cytophagous phagocytic function, Improve the multiplication capacity of lymphocyte.

Three antitumor

Lycium barbarum polysaccharide is not only the immunoreactive biological response modifier of a kind of regulation, and can be by neural--endocrine-- Immune Regulative Network plays antitumaous effect.

Four resisting fatigue

Lycium barbarum polysaccharide can dramatically increase Mouse Muscle glycogen, liver glycogen reserves amount, and before and after improving motion, blood lactic acid dehydrogenase is always lived Power；Reduce blood urea nitrogen increments after mice strenuous exercise, the clearance rate of blood urea nitrogen after accelerating to move.This shows Fructus Lycii Polysaccharide has fairly obvious effect to allaying tiredness.

Five Antiradiation injuries

Fructus Lycii has anti-gamma radiation, the effect of protection body, can carry out the antineoplastons such as Combined with Radiotherapy as ancillary drug, Alleviate the toxic and side effects of radiotherapy, improve curative effect, the immunologic function of protection body.

Six regulation blood fat

Fructus Lycii can effectively reduce triglyceride and the content of cholesterol in the rat blood serum suffering from hyperlipemia, has significantly fall Blood fat, regulation lipid metabolism function, have positive role to prevention cardiovascular disease.

Seven blood sugar lowering

Lycium barbarum polysaccharide can be remarkably reinforced the activity of superoxide dismutase (SOD) in damaged islet cells, improves islet cells Oxidation resistance, alleviates the peroxide damage to cell, and dialdehyde growing amount in reducing, this shows that lycium barbarum polysaccharide is thin to islets of langerhans Born of the same parents have certain protective effect.

Eight blood pressure lowering

Lycium barbarum polysaccharide can reduce rat blood pressure (shrink pressure and diastolic pressure all takes effect really)；Reduce malonaldehyde in blood plasma and blood vessel, Content of ET, increases the release of calcitonin-gene-related peptide, prevents hypertension from being formed.

Nine protection reproductive system

Lycium barbarum polysaccharide can make the serum sex hormone level of the people Mus of testis damaged raise；Increase testis, the organ coefficient of epididymis, Improve rat testis SOD activity, reduce mda content, make impaired testis tissue return to close to normal level.

Ten improve vision

The retinal photoreceptor of human body is to be made up of retinol and opsin, contained abundant B mono-carotene in Fructus Lycii Vitamin A can be changed in human body, and vitamin A can generate retinol, thus improve vision, prevent maculopathy.

11 improve respiratory tract resistance against diseases

Fructus Lycii, rich in carotene, can change into vitamin A in human body, has maintenance epithelial tissue normal growth and differentiation Function, amount can be prevented nose, pharynx, larynx and other respiratory tract infection, be improved respiratory tract resistance against diseases time sufficient.

12 looks improving and the skin nourishing, Glycerin

Skin aging is caused mainly due to free-radical oxidation, and lycium barbarum polysaccharide contained in Fructus Lycii, B mono-carotene are all It is the antioxidant of strength, adds the synergism of the trace element-selenium contained by Fructus Lycii and vitamin E, constitute powerful Antioxidation army；It addition, vitamin A can maintain cattle length and the differentiation of epithelial tissue, prevent xerosis cutis and follicular keratosis, Thus play the effect of looks improving and the skin nourishing, Glycerin.

Prior art does not disclose the anti-oxidation function of the Chinese prescription of the above medicine formation of the present invention, leads to for this present invention Cross experiment and obtain a kind of new Chinese medicine composition with antioxidation and its preparation method.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine composition with anti-oxidation function and preparation thereof.

It is a further object of the present invention to provide the preparation method of this Chinese medicine composition.

Additionally, present invention also offers the application that this Chinese medicine composition has on the health food of anti-oxidation function in preparation.

The present invention is achieved through the following technical solutions:

The Chinese medicine composition of the present invention, is to be that crude drug is prepared from the Chinese medicine of following weight proportion:

Fructus Jujubae 8-25 part, Radix Ginseng Rubra 4-12 part, Radix Ophiopogonis 8-16 part, Fructus Schisandrae Chinensis 3-8 part, Fructus Lycii 8-20 part.

Preferred Chinese medicine composition of the present invention, is to be that crude drug is prepared from: Fructus Jujubae with the Chinese medicine of following weight proportion 15-25 part, Radix Ginseng Rubra 5-8 part, Radix Ophiopogonis 10-14 part, Fructus Schisandrae Chinensis 3-6 part, Fructus Lycii 15-20 part.

Most preferred Chinese medicine composition of the present invention, is to be that crude drug is prepared from the Chinese medicine of following weight proportion: big Fructus Jujubae 20 parts, Radix Ginseng Rubra 6 parts, Radix Ophiopogonis 12 parts, Fructus Schisandrae Chinensis 4 parts, Fructus Lycii 18 parts.

Composition described above is by weight as proportioning, can increase according to corresponding proportion when producing or reduce, such as large-scale production Can be in units of kg, or with t (ton) as unit；Preparation can also be in units of g on a small scale.Weight can increase or Person reduces, but the constant rate of the raw medicinal herbs weight proportion between each composition.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or The patient of slight of stature, can adjust the proportioning of the amount of composition accordingly, be increased or decreased less than 10%, and drug effect is basically unchanged.

The Chinese medicine composition of the present invention, is that the raw material of Chinese medicine medical material by being formed by above-mentioned formula adds through extraction or other modes Work, makes pharmaceutically active substance, subsequently, with this material as raw material, adds pharmaceutically acceptable carrier, according to system when needing The routine techniques of agent is made.Described active substance can obtain by pulverizing respectively or extracting raw material of Chinese medicine, it is also possible to logical Cross common pulverizing or extraction raw material of Chinese medicine medical material obtains, it is also possible to obtain by other means, such as: by pulverizing, squeezing, Grind, sieve, percolation, extraction, water carry, alcohol extraction, ester carry, method obtains, these active substances can be powder for chromatography etc. End form or the material of extractum form, can be dry extract can also be fluid extract, need decision to make according to the difference of preparation Different concentration.

The pharmaceutical dosage forms of the Chinese medicine composition of the present invention, preferably unit dose, can make when making pharmaceutical preparation Become any pharmaceutically useful dosage form.

One of according to the embodiment of the present invention, the Chinese medicine composition of the present invention, for any one oral dosage form, these Dosage form is selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, Oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid.

Preferably, Chinese medicine composition is oral liquid.

The Chinese medicine composition of the present invention, can add some pharmaceutically acceptable carriers as required, and galenic pharmacy can be used normal Rule technology prepares this pharmaceutical preparation, as mixed with pharmaceutically acceptable carrier by pharmaceutically active substance.Described pharmaceutically acceptable Carrier be selected from: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, Cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, EDTA Disodium, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfur Acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextrose Glycosides, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, bright Glue, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid Paraffin body, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, Calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, Calcium stearate, magnesium stearate etc..

The Chinese medicine composition of the present invention, when making medicament, the medicament of unit dose can be containing the pharmaceutically active substance of the present invention 0.1-1000mg, remaining is pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be total formulation weight by weight The 0.1-99.9% of amount.

The Chinese medicine composition of the present invention, can also be prepared as health food as required, including: beverage, cookies, bread, Confection, canned food, and any one can add food therein.

The Chinese medicine composition of the present invention determines usage and dosage according to practical situation in use.

Pharmaceutically active substance of the present invention can use following methods to prepare:

(1) Fructus Jujubae, Fructus Lycii are through extracting 2-4 time with the boiling of 7-10 times amount water, each 0.5-2h, filtration, Aqueous extracts Standby；

(2) Radix Ophiopogonis, Fructus Schisandrae Chinensis 6-9 times amount water boiling are extracted 2-4 time, and extraction time is respectively 0.5-2h, closes And extracting solution, it is evaporated to relative density 1.15-1.16 when 50 DEG C, adding ethanol to alcohol content is 60-90%, stirring Uniformly, cold more than the 4-12h that puts, collect precipitation, be dissolved in water precipitation, is evaporated to relative density when 50 DEG C and is 1.04-1.06, obtain extractum standby；

(3) Radix Ginseng Rubra 6-9 times amount water extraction 2-4 time, each 30-60min, united extraction liquid, be evaporated to Relative density 1.15-1.16 when 50 DEG C, adding ethanol to alcohol content is 60-90%, stirs, and cold puts more than 4-12h, Collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density when 50 DEG C is 1.04-1.06, obtains extractum standby；

(4) by step (1) gained Aqueous extracts, step (2) gained extractum, the mixing of step (3) gained extractum, concentrate, Obtain pharmaceutically active substance.

Preferably, the preparation method that the present invention provides is as follows:

(1) Fructus Jujubae, Fructus Lycii are through extracting 2 times with 8 times amount water boilings, and each 1h, filtration, Aqueous extracts is standby；

(2) Radix Ophiopogonis, Fructus Schisandrae Chinensis extract 3 times with 7 times amount water boilings, and extraction time is respectively 1h, 45min, 30min, United extraction liquid, is evaporated to 50 DEG C of relative densities 1.15-1.16, and adding ethanol to alcohol content is 75%, and stirring is all Even, cold more than the 12h that puts, collect precipitation, be dissolved in water precipitation, and being evaporated to 50 DEG C of relative densities is 1.04-1.06, Obtain extractum standby；

(3) Radix Ginseng Rubra 8 times amount water extraction 3 times, each 45min, united extraction liquid, is evaporated to 50 DEG C relatively Density 1.15-1.16, adding ethanol to alcohol content is 75%, stirs, cold more than the 12h that puts, and collects precipitation, adds water Dissolution precipitation, being evaporated to 50 DEG C of relative densities is 1.04-1.06, obtains extractum standby；

(4) by step (1) gained Aqueous extracts, step (2) gained extractum, the mixing of step (3) gained extractum, Concentrate, obtain pharmaceutically active substance.

One of according to the embodiment of the present invention, gained pharmaceutically active substance can add water further and be deployed into suitable mouth Take liquid concentration, the most conventional canned, sterilizing, lamp inspection, obtain finished product.(seeing accompanying drawing 1)

Pharmaceutically active substance of the present invention has an application on the health food of anti-oxidation function in preparation:

Below by way of experimental data beneficial effects of the present invention is described:

(1) experiment material

1, test sample

Chinese prescription (is prepared according to the method for the embodiment of the present invention 1, health care Food Research Inst. of Tasly Institute carries For)

2, positive control drug

Vitamin C (Sigma company, lot number SLBH4167V)

3, laboratory animal

ICR mice: SPF level, 72, female.

At the monthly age: wherein 60 is 10 monthly age aged mouses, 12 is 3 monthly age youth mices.

Animal origin: provided by Yangzhou University's comparative medicine center, licence: SCXK (Soviet Union) 2012-0004.

Rearing conditions: barrier animal room is raised, and temperature is 20 DEG C～25 DEG C, relative humidity 60%, 10, every cage, illumination 12 hours time, adding feedstuff at regular time and quantity, Mus full-valence pellet feed is (purchased from Jiangning county's Qinglongshan animal reproduction , its quality meets GB14924.1-2001 " laboratory animal mixed feed general-quality criteria "), freely drink water, every day Change bedding and padding.Facility uses credit number: SYXK (Soviet Union) 2012-0035.

4, reagent

Malonaldehyde (MDA) testing cassete, lot number: 20140627；Superoxide dismutase (SOD) testing cassete, lot number 20140701；Trace reduced glutathion (GSH) testing cassete, lot number: 20170702；Content of protein carbonyl group is tested Box, lot number: 20140705；It is purchased from Nanjing and builds up Bioengineering Research Institute.

5, instrument

KD-160 type electronic scale, Dongguan Paribas health equipment company limited；

BSA124S precision electronic balance (0.1mg～120g), Germany Sai Duolisi；

TDL80-2B desk centrifuge, Anting Scientific Instrument Factory, Shanghai；

Safire²Plate reading, TECAN (Switzerland).

(2) experimental technique

1, test dose design considerations

Crowd's operational version: recommending human intaking amount is 50ml/ bottle/day (oral liquid), i.e. 0.83ml/kg/d.

About " the anti-oxidation function method of inspection " zoopery dose design in " health food Toxicological evaluation specification " Principle " is one of them dosage group with 10 times (mices) or 5 times (rat) of human body recommended amounts, separately sets two agent Amount group, high dose is usually no more than 30 times ".

According to above-mentioned background information, consider, as follows for this zooperal dose design of Chinese prescription antioxidation Table:

Table 1 experiment packet and dosage

2, test sample gives approach and number of times

(1) give test sample approach and be administered volume: being administered volume gastric infusion according to 0.2ml/10g BW, be administered once daily.

(2) the test sample time limit is given: continuous 30 days.

(3) test sample preparation: preparing test sample every day, animal is weighed once weekly, and according to measure the weight of animals adjust to Dose.

3, experimental technique

(1) animal packet and process

After Animal adaptability is fed 7 days, in addition to young control mice, all aged mouse eye sockets take blood, under conditions of 4 DEG C, 3500r/min is centrifuged 10min, separates serum, uses MDA content in kit measurement serum, then according to MDA Content is divided into 5 groups immediately, aged controls group, vitamin C matched group, Chinese prescription basic, normal, high dosage group, often group 12.

After animal packet, dosage gavage every day as shown in table 1 gives corresponding tested material, successive administration 30 days, and gavage is tied Shu Hou, plucks eyeball and takes blood, and under conditions of 4 DEG C, 3500r/min is centrifuged 10min, separates serum, is placed in-20 DEG C of storages standby With；Taking hepatic tissue normal saline and make 10% homogenate, under conditions of 4 DEG C, 3500r/min is centrifuged 20min, takes supernatant It is placed in-20 DEG C of storages standby.

(2) observation index

Conventional index is surveyed: timing measures the body weight of test mice weekly.

Serum Indexes: by MDA content, content of protein carbonyl group, GSH content, SOD activity in kit measurement blood.

Liver organization: with MDA content, content of protein carbonyl group, GSH content, SOD in kit measurement liver organization Activity.

4, statistical method

Use SPSS11.5 software analysis, data withRepresent, compare the significance of group difference with t inspection.P<0.05 Significant is had for difference.

5, result

(1) impact on body weight

During test, young control mice body weight increases normal.Aged mouse body weight is significantly higher than young mice, is subject to during test Examination thing is respectively organized Mouse Weight and is kept stable, has no that test medicine significantly affects (table 2) to body weight.

The table 2 Chinese prescription gastric infusion impact on aged mouse body weight in 1 month (M ± SD)

(2) impact on Biochemical Indices In Serum

Compared with young control mice, aged mouse serum MDA and protein carbonyl group level significantly raised (P < 0.05), SOD Vigor is decreased obviously (P < 0.05), and GSH level also has part to reduce.Chinese prescription high dose is to aged mouse serum MDA With protein carbonyl group level, SOD vigor, there is significant improvement result (P < 0.05, P < 0.01), in, low dosage also has Part improvement result.3 dosage groups of Chinese prescription all have no significant effect (table 3) to aged mouse serum GSH level.

The table 3 Chinese prescription gastric infusion impact on aged mouse serum oxidative biochemical indicator in 1 month (M ± SD)

* P < 0.05, compared with YC group；^#P < 0.05,^##P < 0.01, compared with OC group.

(3) impact on liver biochemical indexes

Compared with young control mice, aged mouse liver MDA and protein carbonyl group level significantly raise (P < 0.01), GSH Level and SOD vigor are remarkably decreased (P < 0.01).Chinese prescription high dose is to aged mouse liver MDA and protein carbonyl Base level, SOD vigor have significant improvement result (P < 0.05, P < 0.01), in, low dosage also have part improve make With.3 dosage groups of Chinese prescription all have no significant effect (table 4) to aged mouse liver GSH level.

The impact (M ± SD) on aged mouse liver oxidation biochemical indicator in 1 month of table 4 Chinese prescription gastric infusion

* P < 0.01, compared with YC group；^#P < 0.05,^##P < 0.01, compared with OC group.

(3) conclusion

This experimental selection natural aging mice, by the MDA in investigation serum and liver organization, GSH, protein carbonyl group Level and SOD vigor, investigate the interior antioxidation action of Chinese prescription.Chinese prescription set height (16.8ml/kg), in (8.4ml/kg), low (4.2ml/kg) 3 dosage groups, be approximately equivalent to the 20 of people's dosage, 10 and 5 times respectively, continuously Gastric infusion 1 month, uses and aoxidizes related biochemical indicator in kit measurement serum and liver.Result shows, this product is continuous Aged mouse serum and liver MDA, protein carbonyl group level and SOD vigor are had and are obviously improved by gastric infusion 1 month Effect, with reference to health food inspection and assessment technique specification (version in 2003) evaluation criterion, shows that this product has certain Interior antioxidation action.

Accompanying drawing illustrates:

Fig. 1 is the preparation method schematic flow sheet according to one of embodiment of the present invention.

Detailed description of the invention:

Further illustrate the present invention by the following examples, but not as limitation of the present invention.

Embodiment 1

Taking 20 parts of Fructus Jujubae, Fructus Lycii 18 parts, through extracting 2 times with 8 times amount water boilings, each 1h, filtration, feed liquid is standby. Taking Radix Ophiopogonis 12 parts, Fructus Schisandrae Chinensis 4 parts, extract 3 times with 7 times amount water boilings, extraction time is respectively 1h, 45min, 30min. United extraction liquid, is evaporated to relative density 1.15-1.16 (50 DEG C), and adding ethanol to alcohol content is 75%, stirs, Cold put more than 12h.Collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby. Take Radix Ginseng Rubra 6 parts, with 8 times amount water extraction 3 times, each 45min, united extraction liquid, be evaporated to relative density 1.15-1.16 (50 DEG C), adding ethanol to alcohol content is 75%, stirs, and cold puts more than 12h.Collecting precipitation, be dissolved in water precipitation, Being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby.

By Fructus Jujubae, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra, Fructus Schisandrae Chinensis extractive solution mixing, concentrate drying, obtain pharmaceutically active substance, add By this pharmaceutically active substance, with galenic pharmacy routine techniques through allotment, fill.Sterilizing, lamp inspection, vanning, obtain the present invention Chinese prescription oral liquid formulations.

Embodiment 2

Taking 8 parts of Fructus Jujubae, Fructus Lycii 20 parts, through extracting 4 times with 7 times amount water boilings, each 30min, filtration, feed liquid is standby With.Take Radix Ophiopogonis 10 parts, Fructus Schisandrae Chinensis 8 parts, extract 4 times with 6 times amount water boilings, extract 30min every time.United extraction Liquid, is evaporated to relative density 1.15-1.16 (50 DEG C), and adding ethanol to alcohol content is 60%, stirs, and cold puts 12h Above.Collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby.Take Radix Ginseng Rubra 12 parts, with 6 times amount water extraction 4 times, each 30min, united extraction liquid, it is evaporated to relative density 1.15-1.16 (50 DEG C), adding ethanol to alcohol content is 60%, stirs, and cold puts more than 10h.Collecting precipitation, be dissolved in water precipitation, Being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby.

By Fructus Jujubae, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra, Fructus Schisandrae Chinensis extractive solution mixing, add water allotment.Heated and boiled, carries out fill. Sterilizing, lamp inspection, vanning, obtain the Chinese prescription oral liquid formulations of the present invention.

Embodiment 3

Taking 15 parts of Fructus Jujubae, Fructus Lycii 8 parts, through extracting 2 times with 10 times amount water boilings, each 2h, filtration, feed liquid is standby. Take Radix Ophiopogonis 16 parts, Fructus Schisandrae Chinensis 3 parts, extract 2 times with 9 times amount water boilings, extract 2h every time.United extraction liquid, decompression Being concentrated into relative density 1.15-1.16 (50 DEG C), adding ethanol to alcohol content is 90%, stirs, and cold puts more than 10h. Collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby.Take Radix Ginseng Rubra 4 parts, With 9 times amount water extraction 2 times, each 1h, united extraction liquid, it is evaporated to relative density 1.15-1.16 (50 DEG C), adds Ethanol is 90% to alcohol content, stirs, and cold puts more than 4h.Collecting precipitation, be dissolved in water precipitation, is evaporated to Relative density is that 1.04-1.06 (50 DEG C) is standby.

By Fructus Jujubae, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra, Fructus Schisandrae Chinensis extractive solution mixing, concentrate, add proper auxiliary materials, according to routine side Method is prepared as tablet.

Embodiment 4

Taking 10 parts of Fructus Jujubae, Fructus Lycii 10 parts, through extracting 3 times with 9 times amount water boilings, each 45min, filtration, feed liquid is standby With.Take Radix Ophiopogonis 8 parts, Fructus Schisandrae Chinensis 4 parts, extract 3 times with 8 times amount water boilings, extract 45min every time.United extraction liquid, Being evaporated to relative density 1.15-1.16 (50 DEG C), adding ethanol to alcohol content is 80%, stirs, and cold puts more than 4h. Collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density is that 1.04-1.06 (50 DEG C) is standby.Take Radix Ginseng Rubra 5 parts, With 9 times amount water extraction 3 times, each 45min, united extraction liquid, it is evaporated to relative density 1.15-1.16 (50 DEG C), Adding ethanol to alcohol content is 80%, stirs, and cold puts more than 12h.Collecting precipitation, be dissolved in water precipitation, concentrating under reduced pressure It is that 1.04-1.06 (50 DEG C) is standby to relative density.

By Fructus Jujubae, Fructus Lycii, Radix Ophiopogonis, Radix Ginseng Rubra, Fructus Schisandrae Chinensis extractive solution mixing, concentrate, add proper auxiliary materials, according to routine side Method is prepared as capsule.

Embodiment 5

By the pharmaceutically active substance in embodiment 1, mix with any food, be prepared as health food.

Embodiment 6

By the pharmaceutically active substance in embodiment 1, add water and sugar, be prepared as health beverage.

Embodiment 7

By the pharmaceutically active substance in embodiment 1, add flour, be prepared as cookies.

Claims (10)

1. a Chinese medicine composition with anti-oxidation function, it is characterised in that described Chinese medicine composition is to use following weight proportion Chinese medicine be that crude drug is prepared from: Fructus Jujubae 8-25 part, Radix Ginseng Rubra 4-12 part, Radix Ophiopogonis 8-16 part, Fructus Schisandrae Chinensis 3-8 part, Fructus Lycii 8-20 part.

2. Chinese medicine composition as claimed in claim 1, it is characterised in that be to be crude drug system with the Chinese medicine of following weight proportion Standby form: Fructus Jujubae 15-25 part, Radix Ginseng Rubra 5-8 part, Radix Ophiopogonis 10-14 part, Fructus Schisandrae Chinensis 3-6 part, Fructus Lycii 15-20 part.

3. Chinese medicine composition as claimed in claim 2, it is characterised in that be to be crude drug system with the Chinese medicine of following weight proportion For forming: 20 parts of Fructus Jujubae, Radix Ginseng Rubra 6 parts, Radix Ophiopogonis 12 parts, Fructus Schisandrae Chinensis 4 parts, Fructus Lycii 18 parts.

4. Chinese medicine composition as claimed in claim 1, it is characterised in that the Chinese medicine composition of the present invention, for any one mouth Formulation form, these dosage forms are selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, ebonite Wafer, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid.

5. Chinese medicine composition as claimed in claim 1, it is characterised in that described Chinese medicine composition is oral liquid.

6. Chinese medicine composition as claimed in claim 1, it is characterised in that described pharmaceutically active substance, the most also may be used To be prepared as health food, including beverage, cookies, bread, confection, canned food, and any one can add wherein Food.

7. the preparation method of the Chinese medicine composition described in claim 1, it is characterised in that step is as follows:

(1) Fructus Jujubae, Fructus Lycii are through extracting 24 times with 7 10 times amount water boilings, and each 0.5 2h, filtration, Aqueous extracts is standby；

(2) Radix Ophiopogonis, Fructus Schisandrae Chinensis extract 24 times with 69 times amount water boilings, and extraction time is respectively 0.5 2h, united extraction liquid, Being evaporated to relative density 1.15 1.16 when 50 DEG C, adding ethanol to alcohol content is 60 90%, stirs, and cold puts 4 12h Above, collecting precipitation, be dissolved in water precipitation, and being evaporated to relative density when 50 DEG C is 1.04 1.06, obtains extractum standby With；

(3) Radix Ginseng Rubra 69 times amount water extraction 24 times, each 30 60min, united extraction liquid, be evaporated to 50 DEG C of phases To density 1.15 1.16, adding ethanol to alcohol content is 60 90%, stirs, cold 4 more than the 12h that put, and collects precipitation, Be dissolved in water precipitation, and being evaporated to relative density when 50 DEG C is 1.04 1.06, obtains extractum standby；

(4) by step (1) gained Aqueous extracts, step (2) gained extractum, the mixing of step (3) gained extractum, concentrate, i.e. Obtain pharmaceutically active substance.

8. the preparation method of the Chinese medicine composition described in claim 7, it is characterised in that step is as follows:

(1) Fructus Jujubae, Fructus Lycii are through extracting 2 times with 8 times amount water boilings, and each 1h, filtration, Aqueous extracts is standby；

(2) Radix Ophiopogonis, Fructus Schisandrae Chinensis extract 3 times with 7 times amount water boilings, and extraction time is respectively 1h, 45min, 30min, merges Extracting solution, is evaporated to 50 DEG C of relative densities 1.15 1.16, and adding ethanol to alcohol content is 75%, stirs, and cold puts More than 12h, collects precipitation, and be dissolved in water precipitation, and being evaporated to 50 DEG C of relative densities is 1.04 1.06, obtains extractum standby With；

(3) Radix Ginseng Rubra 8 times amount water extraction 3 times, each 45min, united extraction liquid, be evaporated to 50 DEG C of relative densities 1.15 1.16, adding ethanol to alcohol content is 75%, stirs, cold more than the 12h that puts, and collects precipitation, and be dissolved in water precipitation, Being evaporated to 50 DEG C of relative densities is 1.04 1.06, obtains extractum standby；

(4) by step (1) gained Aqueous extracts, step (2) gained extractum, the mixing of step (3) gained extractum, concentrate, i.e. Obtain pharmaceutically active substance.

9. the preparation method of the Chinese medicine composition described in claim 8, it is characterised in that gained pharmaceutically active substance can enter Step adds water and is deployed into suitable oral liquid concentration, the most conventional canned, sterilizing, lamp inspection, obtains finished product.

10. the application in preparing the Chinese medicine and health food with anti-oxidation function of the Chinese medicine composition described in claim 1.